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view test-data/create/sequences.ffdata @ 3:4def47766a3c draft default tip
"planemo upload commit fe7295ad48151648562b06d5b075a68d77747326"
| author | guerler |
|---|---|
| date | Thu, 08 Apr 2021 18:20:04 +0000 |
| parents | ad4b7db26523 |
| children |
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Query NP_000282.1 Match_columns 417 No_of_seqs 604 out of 4515 Neff 6.98956 Searched_HMMs 787 Date Fri Jul 24 20:35:21 2020 Command /home/guerler/hh-suite/build/bin/hhblits -i /home/guerler/human/fasta/NP_00/NP_000282.1.fasta -d /home/guerler/pdb70/pdb70 -o /home/guerler/human/hhr/NP_00/NP_000282.1.hhr No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 2WZB_A PHOSPHOGLYCERATE KINASE 100.0 9E-114 7E-118 875.1 0.0 415 3-417 2-416 (416) 2 1HDI_A PHOSPHOGLYCERATE KINASE 100.0 4E-113 3E-117 868.7 0.0 412 6-417 2-413 (413) 3 6Y3A_A Phosphoglycerate kinase 100.0 3E-112 2E-116 865.4 0.0 414 2-416 9-423 (424) 4 3UWD_A Phosphoglycerate kinase 100.0 7E-112 6E-116 855.6 0.0 391 4-416 1-393 (394) 5 1QPG_A 3-PHOSPHOGLYCERATE KINA 100.0 7E-112 6E-116 861.3 0.0 413 2-416 1-413 (415) 6 3PGK_A PHOSPHOGLYCERATE KINASE 100.0 8E-112 7E-116 861.3 0.0 413 2-416 2-414 (416) 7 3Q3V_A Phosphoglycerate kinase 100.0 3E-111 3E-115 852.3 0.0 392 2-416 3-399 (403) 8 1PHP_A 3-PHOSPHOGLYCERATE KINA 100.0 1E-110 9E-115 847.6 0.0 387 8-416 5-393 (394) 9 1VPE_A PHOSPHOGLYCERATE KINASE 100.0 1E-110 1E-114 848.4 0.0 392 6-416 2-395 (398) 10 4FEY_A Phosphoglycerate kinase 100.0 6E-110 5E-114 842.0 0.0 388 2-416 2-391 (395) 11 1V6S_B Phosphoglycerate kinase 100.0 1E-109 1E-113 838.8 0.0 386 7-416 2-390 (390) 12 3ZLB_A PHOSPHOGLYCERATE KINASE 100.0 2E-109 1E-113 840.0 0.0 394 4-416 1-397 (398) 13 4EHJ_A Phosphoglycerate kinase 100.0 2E-109 2E-113 837.1 0.0 386 4-416 1-388 (392) 14 16PK_A 3-PHOSPHOGLYCERATE KINA 100.0 4E-109 4E-113 840.3 0.0 395 6-416 2-414 (415) 15 3OZ7_B Phosphoglycerate kinase 100.0 4E-109 4E-113 840.5 0.0 413 3-416 4-417 (417) 16 4DG5_A Phosphoglycerate kinase 100.0 5E-109 4E-113 836.1 0.0 392 5-416 9-402 (403) 17 6HXE_A Phosphoglycerate kinase 100.0 4E-108 4E-112 826.1 0.0 381 4-416 1-383 (387) 18 4NG4_B Phosphoglycerate kinase 100.0 5E-108 4E-112 830.0 0.0 389 1-416 9-399 (404) 19 4NG4_C Phosphoglycerate kinase 100.0 5E-108 4E-112 830.0 0.0 389 1-416 9-399 (404) 20 6I06_A Phosphoglycerate kinase 100.0 1E-107 9E-112 823.4 0.0 381 4-416 1-383 (387) 21 2CUN_A Phosphoglycerate kinase 100.0 3E-105 3E-109 811.0 0.0 387 8-416 3-400 (410) 22 1FW8_A PHOSPHOGLYCERATE KINASE 100.0 8.8E-90 7.6E-94 698.3 0.0 342 74-416 2-343 (416) 23 1FW8_A PHOSPHOGLYCERATE KINASE 99.3 3.2E-16 2.7E-20 156.7 0.0 68 3-70 347-414 (416) 24 2Q33_B D-MONELLIN CHAIN A, D-M 34.3 5.9 0.00042 24.6 0.0 11 310-320 2-12 (48) No 1 >2WZB_A PHOSPHOGLYCERATE KINASE 1 (E.C.2.7.2.3); HEREDITARY HEMOLYTIC ANEMIA, TRANSFERASE, PHOSPHOPROTEIN; HET: ADP, 3PG; 1.47A {HOMO SAPIENS} Probab=100.00 E-value=8.6e-114 Score=875.06 Aligned_cols=415 Identities=100% Similarity=1.449 Sum_probs=363.4 Template_Neff=6.400 Q NP_000282.1 3 LSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVA 82 (417) Q Consensus 3 ~~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va 82 (417) +..|++++|.|++|||||||+|+|||+++++|.|++||++++|||+||+++||++|||+||+|||+++..++.+||+||+ T Consensus 2 ~~~~~~l~~~~l~gK~vlvR~D~NVPl~~~~i~dd~RI~~~lpTI~~Ll~~gak~vil~sHlGrP~g~~~~~~~Sl~pv~ 81 (416) T 2WZB_A 2 LSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVA 81 (416) T ss_dssp CTTBCBGGGCCCTTCEEEEECCCCCCEETTEESCCHHHHHHHHHHHHHHHTTCSEEEEECCCSCCTTSCCHHHHCSHHHH T ss_pred CcccccccccccCCCEEEEEeEccccccCCccCCChHHHHHHHHHHHHHHCCCCEEEEEeeCCCCCCCCCCcccChHHHH Confidence 45788898889999999999999999998899999999999999999999999448999999999875323479999999 Q NP_000282.1 83 VELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYV 162 (417) Q Consensus 83 ~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyV 162 (417) ++|+++|+.+|.|+++|+|+++++.++.+++|+|+||||+|||++|+++++++++|+.+++.+++.+|+++||+++|+|| T Consensus 82 ~~L~~~l~~~v~f~~d~~g~~~~~~i~~~~~g~illLENlRF~~~E~~~~~~~~~n~~k~~~~~~~~fa~~La~l~DiyV 161 (416) T 2WZB_A 82 VELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYV 161 (416) T ss_dssp HHHHHHHTSCCEECSCSSSHHHHHHHHSCCTTEEEECCCGGGSHHHHTCC----------CHHHHHHHHHHHHHTCSEEE T ss_pred HHHHHHhCCEEEEcccCCCHHHHHHHhCCCCCcEEEEeccccchhhcCCCCCCCCccccCCHHHHHHHHHHHhcccceEE Confidence 99999998779999999998888888899999999999999998776331111111111112234679999999999999 Q NP_000282.1 163 NDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAF 242 (417) Q Consensus 163 NDAFg~aHR~~aS~~gi~l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a~ 242 (417) |||||++||.|||++++++|+++||++|++||++|++++++|+||+++|+||+|++||+++|++|+++||.|++||+||| T Consensus 162 NDAF~~~HR~hAS~vgi~lp~s~aG~ll~kEl~~L~~~~~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~IligG~~a~ 241 (416) T 2WZB_A 162 NDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAF 241 (416) T ss_dssp ECCGGGTTCCCHHHHCCCCSCEEECHHHHHHHHHHHHHHHSCCSSEEEEECSSCHHHHGGGHHHHTTTCSEEEECGGGHH T ss_pred ecccccCCCccccccccCCCccchHHHHHHHHHHHHHHhcCCCCCEEEEEcCCCHHHHHHHHHHHHHhCCEEEeCcHHHH Confidence 99999999999999999976589999999999999999999999999999999999999999999998999999999999 Q NP_000282.1 243 TFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSK 322 (417) Q Consensus 243 tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti~ 322 (417) +||+|++++++|+|++|++..+.|++++++|+.++++|+||+|++|.+.+..+.....+.....+|++|+++||||+|++ T Consensus 242 tfL~a~~~~~ig~S~~e~~~~~~a~~il~~a~~~~~kI~LP~D~vv~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti~ 321 (416) T 2WZB_A 242 TFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSK 321 (416) T ss_dssp HHHHHHHCCCCTTSCCCHHHHTTHHHHHHHHHHTTCEEECCCEEEEESSSSTTCCEEEEETTTCCCTTCEEEEECHHHHH T ss_pred HHHHHhCCCccccceecchHHHHHHHHHHHHHHcCCEEEceeeEEecccccccccCCeeeecCCCCCCceeecCCHHHHH Confidence 99999856689999999999999999999988999999999999999865332211111112378899999999999999 Q NP_000282.1 323 KYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLEL 402 (417) Q Consensus 323 ~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le~ 402 (417) .|+++|++|||||||||||+||.++|++||+++++++++++++++++|+|||||+++++++|+.++++||||||||+||| T Consensus 322 ~~~~~I~~aktI~wNGP~G~~E~~~f~~GT~~ia~al~~~~~~~a~~ivGGGdT~~~~~~~g~~~~~s~vSTGGGA~L~~ 401 (416) T 2WZB_A 322 KYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLEL 401 (416) T ss_dssp HHHHHHHHCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHHHHTTCEEEEESTTHHHHHHHTTCTTSSSEEESCSHHHHHH T ss_pred HHHHHHHhCCEEEEcCCCCcccchhhchHHHHHHHHHHHHhcCCcEEEEecccHHHHHHHcCCCccCeEEecCcHHHHHH Confidence 99999999999999999999998889999999999997632247899999999999998889888899999999999999 Q NP_000282.1 403 LEGKVLPGVDALSNI 417 (417) Q Consensus 403 L~G~~LPgl~aL~~~ 417 (417) |+|++||||++|+++ T Consensus 402 L~G~~LPgieaL~~~ 416 (416) T 2WZB_A 402 LEGKVLPGVDALSNI 416 (416) T ss_dssp HHTCCCHHHHTSCBC T ss_pred HcCCCCchHHHHhcC Confidence 999999999999875 No 2 >1HDI_A PHOSPHOGLYCERATE KINASE (E.C.2.7.2.3); PHOSPHOTRANSFERASE, KINASE, PHOSPHOGLYCERATE, TERNARY COMPLEX; HET: AMP, 3PG; 1.8A {SUS SCROFA} SCOP: c.86.1.1 Probab=100.00 E-value=4.1e-113 Score=868.67 Aligned_cols=412 Identities=91% Similarity=1.360 Sum_probs=361.3 Template_Neff=6.300 Q NP_000282.1 6 KLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVEL 85 (417) Q Consensus 6 ~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~~L 85 (417) +++++|.|++|||||||+|+|||+++++|.|++||++++|||+||+++||++|||+||+|||+++..++.+||+||+++| T Consensus 2 ~~~l~~~~l~gK~vlvR~D~NVPi~~~~i~dd~RI~~~lpTI~~Ll~~gak~vil~sHlGRP~g~~~~~~~Sl~pva~~L 81 (413) T 1HDI_A 2 KLTLDKLNVKGKRVVMRVDFNVPMAAAQITNNARIKAAVPSIKFCLDDGAKSVVLMSHLGRPDGSPMPDKYSLQPVAAEL 81 (413) T ss_dssp BCBGGGSCCTTCEEEEECCCCCCBSSSSBSCCHHHHHHHHHHHHHHHTTCSEEEEECCCSCCCSSCCTTTSCSHHHHHHH T ss_pred CccccccccCCCEEEEEeecCccccccccCCChHHHHHHHHHHHHHHCCCCEEEEEeeCCCCCCCCCCcccccHHHHHHH Confidence 56777788999999999999999988899999999999999999999999448999999999875323479999999999 Q NP_000282.1 86 KSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDA 165 (417) Q Consensus 86 ~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVNDA 165 (417) +++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|+++++++++|+.+.+.+++.+|++.||+++|+||||| T Consensus 82 ~~~l~~~V~f~~d~~g~~~~~~i~~~~~g~illLENlRF~~~E~~~~~~~~~n~~~~~~~~~~~fa~~La~l~DiyVnDA 161 (413) T 1HDI_A 82 KSALGKAVLFLKDCVGPAVEKACADPAAGSVILLENLRFHVEEEGKGKDASGNKAAGEPAKIKAFRASLSALGDVYVNDA 161 (413) T ss_dssp HHHHTSCCEECSCSSSHHHHHHHHSCCTTEEEECCCGGGSHHHHTEEECTTSCEEECCHHHHHHHHHHHHHTCSEEEECC T ss_pred HHHhCCEEEEccccCCHHHHHHhhCCCCCCEEEeeccccchhhcCCCCCCCcccccCCHHHHHHHHHHHHhccccEeecc Confidence 99998779999999998888888999999999999999999776331100011101111224679999999999999999 Q NP_000282.1 166 FGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFL 245 (417) Q Consensus 166 Fg~aHR~~aS~~gi~l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a~tfl 245 (417) |+++||.|||++++++|+++||++|++||++|.+++++|+||+++|+||+|++||+++|++|+++||.|++||+|||+|| T Consensus 162 F~~~HR~hAS~vgi~lp~~~aG~l~~kEi~~L~~~~~~p~rP~v~IlGGaKv~dKi~li~~Ll~~~D~IliGG~~a~tFL 241 (413) T 1HDI_A 162 FGTAHRAHSSMVGVNLPKKAGAFLMKKELNYFAAAAESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFL 241 (413) T ss_dssp GGGTTCCCHHHHCCCCSCEEECHHHHHHHHHHHHHHTSCCSSEEEEECCSCSGGGHHHHHHHHTTCSEEEECGGGHHHHC T ss_pred cccCCCCCCCccccCCchhHHHHHHHHHHHHHHHHHhCCCCCEEEEEcCCCHHHHHHHHHHHHHcCCEEEECchHHHHHH Confidence 99999999999999986579999999999999999999999999999999999999999999999999999999999999 Q NP_000282.1 246 KVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYA 325 (417) Q Consensus 246 ~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti~~~~ 325 (417) +|++++++|+|++|++..+.|++++++|+.++++|++|+|++|.+.+..+...........+|++|+++||||+|++.|+ T Consensus 242 ~a~g~~~iG~Sl~e~~~~~~a~~il~~a~~~~~ki~lP~D~vv~~~~~~~~~~~~~~~~~~ip~~~~ilDIGp~Ti~~~~ 321 (413) T 1HDI_A 242 KVLNNMEIGTSLFDEAGKKIVKNLMSKAAANGVKITLPVDFVTADKFDEQAKIGQATVASGIPAGWMGLDCGPKSSAKYS 321 (413) T ss_dssp CCCCCCCBTTCCCCTTGGGTHHHHHHHHHHHTCEEECCCEEEEESSSSTTCCEEEEETTTCBCTTCEEEEECHHHHHHHH T ss_pred HHhCCCcccceeechhHHHHHHHHHHHHHHCCCeEEceeeEEeccccchhcccceeeecCCCCCCcccccCCHHHHHHHH Confidence 99855689999999999999999999988999999999999999875432211111112378899999999999999999 Q NP_000282.1 326 EAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEG 405 (417) Q Consensus 326 ~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le~L~G 405 (417) ++|++|||||||||||+||.++|++||+++++++++++++++++|+|||||+++++++|+.++++||||||||+||||+| T Consensus 322 ~~I~~aktI~wnGP~G~~E~~~f~~GT~~ia~~i~~~~~~~a~sivGGGdT~~~~~~~g~~~~~~~vSTGGGA~Le~L~g 401 (413) T 1HDI_A 322 EAVARAKQIVWNGPVGVFEWEAFAQGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDNVSHVSTGGGASLELLEG 401 (413) T ss_dssp HHHHHCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHHHHTTCEEEECTTHHHHHHHHTTCTTTSSEECSCHHHHHHHHTT T ss_pred HHHHhCCEEEEeCCCCcccchhhchHHHHHHHHHHHHhcCCcEEEEecccHHHHHHHcCCCCCCEEEecChHHHHHHHcC Confidence 99999999999999999988789999999999997632247899999999999888888888899999999999999999 Q NP_000282.1 406 KVLPGVDALSNI 417 (417) Q Consensus 406 ~~LPgl~aL~~~ 417 (417) +.||||++|+++ T Consensus 402 k~LPgi~aL~~~ 413 (413) T 1HDI_A 402 KVLPGVDALSNV 413 (413) T ss_dssp CCCHHHHTSCBC T ss_pred CCCchHHHhhcC Confidence 999999999874 No 3 >6Y3A_A Phosphoglycerate kinase (E.C.2.7.2.3); phosphoglycerate kinase, metabolic enzyme, kinase; 1.49A {Plasmodium vivax} Probab=100.00 E-value=2.6e-112 Score=865.36 Aligned_cols=414 Identities=59% Similarity=0.970 Sum_probs=363.7 Template_Neff=6.300 Q NP_000282.1 2 SLSNKLTLDKL-DVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEP 80 (417) Q Consensus 2 ~~~~~~~i~~~-~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~ 80 (417) ++.+++++.|. |++|||||||+|+|||+++++|.|++||++++|||+||+++||++|||+||+|||+++. .+++||+| T Consensus 9 ~~~~~~~~~~~~~l~gK~vlvRvD~NVPl~~~~i~dd~RI~~~lpTI~~Ll~~gak~vil~sHlGRP~g~~-~~~~Sl~p 87 (424) T 6Y3A_A 9 SLGNKLSITDVKAIQGKKVLVRVDFNVPIENGVIKDTNRITATLPTIHHLKKEGAAKIILISHCGRPDGTK-NLKYTLKP 87 (424) T ss_dssp CCTTBCBGGGCCCCTTCEEEEECCCCCCEETTEESCCHHHHTTHHHHHHHHHTTCSEEEEECCCSCCTTSC-CGGGCSHH T ss_pred cCCCCccccchHHhCCCEEEEEeecCCcccCCccCCChHHHhHHHHHHHHHHCCCCEEEEEeeCCCCCCCc-cccccHHH Confidence 46788999997 89999999999999999888999999999999999999999994499999999998764 56899999 Q NP_000282.1 81 VAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDV 160 (417) Q Consensus 81 va~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Di 160 (417) |+++|+++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|+++++++++|+.++..+++.+|+++||+++|+ T Consensus 88 va~~L~~~l~~~v~f~~d~~g~~~~~~i~~~~~g~illLENlRF~~~E~~~~~~~~~n~~~~~~~~~~~fa~~LA~l~Di 167 (424) T 6Y3A_A 88 VAETLGTLLGEEVLFLSDCVGEEVAAQINQAKDNSVILLENLRFHVEEEGKGVDAAGNKIKASKEDMEKFQNELTKLGDV 167 (424) T ss_dssp HHHHHHHHHTSCCEECSCSSSHHHHHHHHHSCTTEEEECCCGGGSHHHHSEEECTTSCEEECCHHHHHHHHHHHHTTCSE T ss_pred HHHHHHHHhCCEEEeccccCCHHHHHHHHhccCCCEEEeccccccchhccCCccccccccccCHHHHHHHHHHHhhccCe Confidence 99999999987799999999988888889999999999999999987753211101121111122346799999999999 Q NP_000282.1 161 YVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGM 240 (417) Q Consensus 161 yVNDAFg~aHR~~aS~~gi~l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~ 240 (417) |||||||++||.|||+++++.+.++||++|++||++|++++++|+||+++|+||+|++||+++|++|+++||.|++||+| T Consensus 168 yVNDAF~~~HR~hAS~vgi~~~~s~aG~llekEl~~L~k~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~vD~IligG~~ 247 (424) T 6Y3A_A 168 FINDAFGTAHRAHSSMVGIKMNVKASGFLMKKELEYFSKALENPQRPLLAILGGAKVSDKIQLIKNLLDKVDKMIIGGGM 247 (424) T ss_dssp EEECCGGGTTSCCHHHHCCCCSCEEECHHHHHHHHHHHHHHTSCCSSEEEEEECSCSGGGHHHHHHHHTTCSEEEEESTH T ss_pred EEecccccCccccCcchHHhccHHHhcHHHHHHHHHHHHHHhCCCCCEEEEEcCCCHHHHHHHHHHHHHcCCEEEECcHH Confidence 99999999999999999999322899999999999999999999999999999999999999999999989999999999 Q NP_000282.1 241 AFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPES 320 (417) Q Consensus 241 a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~T 320 (417) ||+||+|++++++|+|++|++..+.|++++++|+.++++|++|+|++|.+.+..+.....+.....+|++|+++||||+| T Consensus 248 a~tfL~a~~~~~ig~s~~e~~~~~~a~~il~~a~~~~~ki~lP~D~vv~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~T 327 (424) T 6Y3A_A 248 AYTFKYVLNNMKIGDSLFDEAGSKIVNEIMEKAKAKNVEIYLPVDFKVADKFDNNANTKVVTDEEGIEDKWMGLDAGPKS 327 (424) T ss_dssp HHHHHHHHHCCCBTTSCCCHHHHTTHHHHHHHHHHTTCEEECCSEEEEESSSSTTSCEEEEETTTCBCTTCEEEEECHHH T ss_pred HHHHHHHHCCCcccchhccchhHHHHHHHHHHHHHCCCeEEeeeeeeeccccCCCCCceEecCccCCCCCcccccCCHHH Confidence 99999997455799999999889999999999989999999999999998753322111122224788999999999999 Q NP_000282.1 321 SKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASL 400 (417) Q Consensus 321 i~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~L 400 (417) ++.|.+.|++|||||||||||+||.++|++||+++++++++++++++++|+|||||+++++++|+.++++||||||||+| T Consensus 328 i~~~~~~I~~aktI~wNGP~G~~E~e~f~~GT~~ia~al~~~~~~~a~~ivGGGdT~~~~~~~g~~~~~s~vSTGGGA~L 407 (424) T 6Y3A_A 328 IENYKDVILSSKTIIWNGPQGVFEMPNFAKGSIECLNLVIEATKKGAISIVGGGDTASLVEQQQKKNEISHVSTGGGASL 407 (424) T ss_dssp HHHHHHHHHTCSEEEEESCSBCTTSGGGCHHHHHHHHHHHHHHHTTCEEEECSHHHHHHHHHTTCGGGSSEECCCTHHHH T ss_pred HHHHHHHHHhCCEEEEeCCCCcccCCCcchhHHHHHHHHHHHhcCCCEEEEechHHHHHHHHhccccCcEEEEechhHHH Confidence 99999999999999999999999988899999999999976322478999999999999988888788999999999999 Q NP_000282.1 401 ELLEGKVLPGVDALSN 416 (417) Q Consensus 401 e~L~G~~LPgl~aL~~ 416 (417) |||+|+.||||++|++ T Consensus 408 e~L~G~~LPgieaL~~ 423 (424) T 6Y3A_A 408 ELLEGKELPGVVALSS 423 (424) T ss_dssp HHHTTCCCHHHHTSCB T ss_pred HHHcCCCCChhHHhhc Confidence 9999999999999975 No 4 >3UWD_A Phosphoglycerate kinase (E.C.2.7.2.3); Anthrax, Structural Genomics, Center for; HET: BTB, MSE; 1.68A {Bacillus anthracis} Probab=100.00 E-value=6.9e-112 Score=855.65 Aligned_cols=391 Identities=48% Similarity=0.845 Sum_probs=357.0 Template_Neff=6.400 Q NP_000282.1 4 SNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAV 83 (417) Q Consensus 4 ~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~ 83 (417) |++++++|.|++|||||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++. .+.+||+||++ T Consensus 1 ~~~~~l~~~~l~gK~vlvR~D~NVPi~~~~i~dd~RI~~~lpTI~~L~~~ga-kvil~sHlGrP~g~~-~~~~sl~~va~ 78 (394) T 3UWD_A 1 MNKKSIRDVDLKGKRVFCRVDFNVPMKEGKITDETRIRAALPTIQYLVEQGA-KVILASHLGRPKGQA-VEELRLTPVAA 78 (394) T ss_dssp CCBCBGGGSCCTTCEEEEECCCCCCC--CCCCCCHHHHHTHHHHHHHHHTTC-EEEEECCCSCCTTSC-CGGGCSHHHHH T ss_pred CCCccccccccCCCEEEEEeecCccccCCCcCCcHHHHHHHHHHHHHHHCCC-cEEEEeccCCCCCcc-chhhChHHHHH Confidence 4567888888999999999999999987899999999999999999999999 599999999999864 56899999999 Q NP_000282.1 84 ELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVN 163 (417) Q Consensus 84 ~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVN 163 (417) +|+++|+.+|.|+++|+|+++++.++.+++|+|+||||+|||++|+++ +.+|++.||+++|+||| T Consensus 79 ~L~~~l~~~v~f~~~~~g~~~~~~i~~~~~g~i~lLENlRf~~~E~~n---------------d~~fa~~La~l~DiyVn 143 (394) T 3UWD_A 79 RLGELLGKDVKKADEAFGPVAQEMVAAMNEGDVLVLENVRFYAGEEKN---------------DAELAKEFAALADIFVN 143 (394) T ss_dssp HHHHHHTSCCEECSCSSSHHHHHHHHTCCTTCEEECCCGGGSHHHHHT---------------CHHHHHHHHTTCSEEEE T ss_pred HHHHHHCCEEeecCccccHHHHHHHHHccCCCEEEEecccccCccccc---------------cHHHHHHHHHhccHHHh Confidence 999999877999999999888888899999999999999999876532 36799999999999999 Q NP_000282.1 164 DAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMA 241 (417) Q Consensus 164 DAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a 241 (417) ||||++||.|||+++++ +| ++||++|++|+++|++++++|+||+++|+||+|++||+++|++|+++||.|++||+|| T Consensus 144 DAF~~~HR~hAS~~gi~~~lp-s~aG~ll~kEl~~L~~~~~~p~~P~v~IlGGaKv~dKi~~i~~Ll~~~d~iligG~~a 222 (394) T 3UWD_A 144 DAFGAAHRAHASTAGIADYLP-AVSGLLMEKELEVLGKALSNPERPFAAIIGGAKVKDKIGLIRHLLDKVDNLIIGGGLA 222 (394) T ss_dssp CCGGGTTSCCTTTTGGGGTSC-EEECHHHHHHHHHHHHHHHSCCSSEEEEECSSCHHHHHHHHHHHTTTCSEEEECSTTH T ss_pred ccHhHhcccccchhhHhhhhH-hhhcHHHHHHHHHHHHHHhCCCCCEEEEECCCCHHHHHHHHHHHHHhCCEEEECChHH Confidence 99999999999999999 77 8999999999999999999999999999999999999999999999999999999999 Q NP_000282.1 242 FTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESS 321 (417) Q Consensus 242 ~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 321 (417) |+||+|+ |+++|+|++|++..+.|++++++|+.++++|++|+|++|.+++...+.. .+...+.+|++|+++||||+|+ T Consensus 223 ~tfL~a~-g~~iG~s~~e~~~~~~a~~il~~a~~~~~ki~lP~D~vv~~~~~~~~~~-~~~~~~~i~~~~~~~DIGp~Ti 300 (394) T 3UWD_A 223 YTFVKAL-GHEIGLSLCEDDKIELAKEFMQLAKEKGVNFYMPVDVVITEEFSETATT-KIVGIDSIPSNWEGVDIGPKTR 300 (394) T ss_dssp HHHHHHT-TCCCTTCCCCGGGHHHHHHHHHHHHHHTCEEECCSEEEEESSCSTTCCE-EEEEGGGCCTTCEEEEECHHHH T ss_pred HHHHHHh-CCcccccccchHHHHHHHHHHHHHHHcCCeEEceeeEEeccccCcccce-EEeccccCCCCceeecCCHHHH Confidence 9999998 8999999999999999999999988899999999999999875432211 1222357889999999999999 Q NP_000282.1 322 KKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 401 (417) Q Consensus 322 ~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le 401 (417) +.|.++|++|||||||||||+||.++|++||+++++++++++ ++++|+|||||+++++++|+.++++||||||||+|| T Consensus 301 ~~~~~~I~~aktI~wnGP~G~~E~e~f~~GT~~i~~ai~~~~--~a~~ivGGGdT~~~~~~~g~~~~~s~vSTGGGA~Le 378 (394) T 3UWD_A 301 EIYADVIKNSKLVVWNGPMGVFEMTPFAEGTKAVGQALADAE--GTYSVIGGGDSAAAVEKFGMADKMSHISTGGGASLE 378 (394) T ss_dssp HHHHHHHHTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHCT--TCEEEECSHHHHHHHHHTTCGGGCSEECCCTHHHHH T ss_pred HHHHHHHhcCCEEEEECCCCcccCCCcChHHHHHHHHHHHcC--CCeEEEechHHHHHHHHcCCCCcceEEEcccHHHHH Confidence 999999999999999999999988889999999999997632 689999999999888888888889999999999999 Q NP_000282.1 402 LLEGKVLPGVDALSN 416 (417) Q Consensus 402 ~L~G~~LPgl~aL~~ 416 (417) ||+|++||||++|++ T Consensus 379 ~L~Gk~LPgl~aL~~ 393 (394) T 3UWD_A 379 FMEGKELPGVVCLND 393 (394) T ss_dssp HHTTCCCHHHHTSCB T ss_pred HHcCCCCCchhhhcc Confidence 999999999999985 No 5 >1QPG_A 3-PHOSPHOGLYCERATE KINASE, MAGNESIUM-5'-ADENYLY-IMIDO-TRIPHOSPHATE, 3-PHOSPHOGLYCERIC ACID; PHOSPHOTRANSFERASE (CARBOXYL ACCEPTOR), KINASE, GLYCOLYSIS; HET: 3PG, MAP; 2.4A {Saccharomyces cerevisiae} SCOP: c.86.1.1 Probab=100.00 E-value=7.2e-112 Score=861.28 Aligned_cols=413 Identities=66% Similarity=1.036 Sum_probs=363.5 Template_Neff=6.500 Q NP_000282.1 2 SLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPV 81 (417) Q Consensus 2 ~~~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~v 81 (417) +..++++++|.|++|||||||+|+|||+++++|.|++||++++|||+||+++||++|||+||+|||+++. ++.+||+|| T Consensus 1 ~~~~~~~i~~~~l~gK~vlvRvD~NVPl~~~~i~dd~RI~~~lpTI~~Ll~~gak~vil~sHlGrP~g~~-~~~~Sl~pv 79 (415) T 1QPG_A 1 SLSSKLSVQDLDLKDKRVFIRVDFNVPLDGKKITSNQRIVAALPTIKYVLEHHPRYVVLASHLGQPNGER-NEKYSLAPV 79 (415) T ss_dssp CTTSBCBGGGCCCTTCEEEEECCCCCCBSSSSBSCCHHHHHHHHHHHHHHTTCCSEEEEECCCSCCCSSC-CGGGCSHHH T ss_pred CCcccccccccccCCCEEEEEEecCCccCCCccCCCHHHHHHHHHHHHHHHcCCCEEEEEeeCCCCCCCc-CcccchHHH Confidence 3567889998999999999999999999888999999999999999999999994489999999998764 568999999 Q NP_000282.1 82 AVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVY 161 (417) Q Consensus 82 a~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Diy 161 (417) +++|+++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|+++.++ ++.+.+++.+++.+|+++||+++|+| T Consensus 80 a~~L~~~l~~~v~f~~d~~g~~~~~~i~~~~~g~illLENlRF~~~E~~~~~~-n~~~~~~~~~~~~~fa~~LA~l~Diy 158 (415) T 1QPG_A 80 AKELQSLLGKDVTFLNDCVGPEVEAAVKASAPGSVILLENLRYHIEEEGSRKV-DGQKVKASKEDVQKFRHELSSLADVY 158 (415) T ss_dssp HHHHHHHHTSCCEEESCSSSHHHHHHHHTCCTTEEEEECCGGGSHHHHTEEEE-TTEEEECCHHHHHHHHHHHHHTCSEE T ss_pred HHHHHHHhCCeEEEccCCCCHHHHHHHHhCCCCCeEehhhhhhcchhcccccc-CCccccCCHHHHHHHHHHHHhcCCeE Confidence 99999999877999999999888888899999999999999999877532000 00000111223478999999999999 Q NP_000282.1 162 VNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMA 241 (417) Q Consensus 162 VNDAFg~aHR~~aS~~gi~l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a 241 (417) ||||||++||.|||++++++|+++||++|++||++|++++++|+||+++|+||+|++||+++|++|+++||.|++||+|| T Consensus 159 VNDAF~~~HR~hAS~vgi~lp~s~aG~ll~kEl~~L~k~l~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~IligG~~a 238 (415) T 1QPG_A 159 INDAFGTAHRAHSSMVGFDLPQRAAGFLLEKELKYFGKALENPTRPFLAILGGAKVADKIQLIDNLLDKVDSIIIGGGMA 238 (415) T ss_dssp EECCGGGTTSCCHHHHCCCCSCEEECHHHHHHHHHHHHHHSSCCSSEEEEECSSCSGGGHHHHHHHTTTCSEEEECGGGH T ss_pred eecccccCCcccccceecCCChhhhcHHHHHHHHHHHHHhhCCCCCEEEEEcCCCHHHHHHHHHHHHHhCCEEEECcHHH Confidence 99999999999999999997658999999999999999999999999999999999999999999999899999999999 Q NP_000282.1 242 FTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESS 321 (417) Q Consensus 242 ~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 321 (417) |+||+|++++++|+|++|++..+.|++++++|+.++++|+||+|++|.+.+..+.....+...+.+|++|+++||||+|+ T Consensus 239 ~tfL~a~~~~~iG~S~~e~~~~~~a~~il~~a~~~~~ki~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 318 (415) T 1QPG_A 239 FTFKKVLENTEIGDSIFDKAGAEIVPKLMEKAKAKGVEVVLPVDFIIADAFSADANTKTVTDKEGIPAGWQGLDNGPESR 318 (415) T ss_dssp HHHHHHHSCCCCCSCCCCHHHHHHHHHHHHHHHHHTCEEECCSEEEEESSSSSSCCCCEEETTTCCCTTCEEEEECHHHH T ss_pred HHHHHHhCCCcCCccccchhhhhHHHHHHHHHHHcCCeEEeeeeEEEecccCCCCCCceeeccCCCCCCCcccccCHHHH Confidence 99999975558999999998889999999998899999999999999886532221111112237889999999999999 Q NP_000282.1 322 KKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 401 (417) Q Consensus 322 ~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le 401 (417) +.|.+.|++|||||||||||+||.++|++||+++++++++++++++++|+|||||+++++++|+.++++||||||||+|| T Consensus 319 ~~~~~~i~~aktI~wnGP~G~~E~~~f~~GT~~ia~~i~~~~~~~a~~ivGGGdT~~~~~~~g~~~~~s~vSTgGGA~L~ 398 (415) T 1QPG_A 319 KLFAATVAKAKTIVWNGPPGVFEFEKFAAGTKALLDEVVKSSAAGNTVIIGGGDTATVAKKYGVTDKISHVSTGGGASLE 398 (415) T ss_dssp HHHHHHHTTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHHHHHTCEEEECCHHHHHHHHHTTCGGGSSEECCCTHHHHH T ss_pred HHHHHHHHcCCEEEEcCCCChhcccccChHHHHHHHHHHHHhcCCCeEEEEehHHHHHHHHcCCCCccEEEEcCchHHHH Confidence 99999999999999999999999888999999999999763224789999999999999888987889999999999999 Q NP_000282.1 402 LLEGKVLPGVDALSN 416 (417) Q Consensus 402 ~L~G~~LPgl~aL~~ 416 (417) ||+|+.||||++|++ T Consensus 399 ~L~G~~LPgieaL~~ 413 (415) T 1QPG_A 399 LLEGKELPGVAFLSE 413 (415) T ss_dssp HHTSCCCHHHHTSCB T ss_pred HHcCCCCChHHHHhh Confidence 999999999999975 No 6 >3PGK_A PHOSPHOGLYCERATE KINASE (E.C.2.7.2.3); PHOSPHOTRANSFERASE(CARBOXYL AS ACCEPTOR), TRANSFERASE; HET: ATP, 3PG; 2.5A {Saccharomyces cerevisiae} SCOP: c.86.1.1 Probab=100.00 E-value=7.8e-112 Score=861.30 Aligned_cols=413 Identities=64% Similarity=1.016 Sum_probs=363.8 Template_Neff=6.500 Q NP_000282.1 2 SLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPV 81 (417) Q Consensus 2 ~~~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~v 81 (417) +..++++++|.|++|||||||+|+|||+++++|.|++||++++|||+||+++||++|||+||+|||+++. ++.+||+|| T Consensus 2 ~~~~~~~~~~~~l~gK~vlvRvD~NVPl~~~~i~dd~RI~~~lpTI~~Ll~~gak~vil~sHlGRP~g~~-~~~~Sl~pv 80 (416) T 3PGK_A 2 SLSSKLSVQDLDLKDKRVFIRVDFNVPLDGKKITSNQRIVAALPTIKYVLEHHPRYVVLASHLGRPNGER-NEKYSLAPV 80 (416) T ss_dssp CCCCSCCSSCCCCSSCCEEEECCCCCCCSSSCCSCCHHHHHHHHHHHHHHHHCCSCCEEECCCCCCCSSS-SCSCCSHHH T ss_pred CCcccccccccccCCCEEEEEEecCCccCCCccCCCHHHHHHHHHHHHHHHcCCCEEEEEeecCCCCCCc-CcccChHHH Confidence 5678899999999999999999999999888999999999999999999999994489999999998764 568999999 Q NP_000282.1 82 AVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVY 161 (417) Q Consensus 82 a~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Diy 161 (417) +++|+++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|+++.++ ++.+.+++.+++.+|++.||+++|+| T Consensus 81 a~~L~~~l~~~v~f~~d~~g~~~~~~i~~~~~g~i~lLENlRF~~~E~~~~~~-n~~~~~~~~~~~~~fa~~La~l~diy 159 (416) T 3PGK_A 81 AKELQSLLGKDVTFLNDCVGPEVEAAVKASAPGSVILLENLRYHIEEEGSRKV-DGQKVKASKEDVQKFRHELSSLADVY 159 (416) T ss_dssp HHHHHHHHCSCEECCCSSCCHHHHHHHHHSSSCEEEECSSCSSCSSCCCCSSS-SSSSCCCCCHHHHHHHHHHHTSCSEE T ss_pred HHHHHHHHCCeeEEcccCCCHHHHHHHHhCCCCCeEehhhhhhcchhcccccc-CCcccccCHHHHHHHHHHHHhcCCeE Confidence 99999999877999999999888888899999999999999999877522000 00001111223477999999999999 Q NP_000282.1 162 VNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMA 241 (417) Q Consensus 162 VNDAFg~aHR~~aS~~gi~l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a 241 (417) ||||||++||.|||++++++|+++||++|++||++|.+++++|+||+++|+||+|++||+++|++|+++||.|++||+|| T Consensus 160 VNDAF~~~HR~hAS~vgi~lp~s~aG~ll~kEl~~L~k~l~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~iligG~~a 239 (416) T 3PGK_A 160 INDAFGTAHRAHSSMVGFDLPQRAAGFLLEKELKYFGKALENPTRPFLAILGGAKVADKIQLIDNLLDKVDSIIIGGGMA 239 (416) T ss_dssp EECSSCSSSSCCTTSSSCCSSCEEECHHHHHHHHHHHHHTSCCSSCBEEEECSSCCSTHHHHHHHHHSSSSCEEEECCHH T ss_pred eecccccCCccccCccccCCchhhhcHHHHHHHHHHHHHhhCCCCCEEEEEcCCCHHHHHHHHHHHHHhCCEEEeCcHHH Confidence 99999999999999999997658999999999999999999999999999999999999999999999899999999999 Q NP_000282.1 242 FTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESS 321 (417) Q Consensus 242 ~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 321 (417) |+||+|++++++|+|++|++..+.|++++++|+.++++|+||+|++|.+.+........+...+.+|++|+++||||+|+ T Consensus 240 ~tfL~a~~~~~iG~s~~e~~~~~~a~~il~~a~~~~~kI~LP~D~vv~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 319 (416) T 3PGK_A 240 FTFKKVLENTEIGDSIFDKAVGPEIAKLMEKAKAKGVEVVLPVDFIIADAFSASANTKTVTDKEGIPAGWQGLDNGPESR 319 (416) T ss_dssp HHHHHSSHHHHHHCSCSCTTHHHHHHHHHHHHHHHTCEECCCSEEEECSSSSSSSCEEEESSCCSSSCSSCCCSCCHHHH T ss_pred HHHHHHhCCCccCcchhcccchHHHHHHHHHHHHcCCeEEccccEEEeccccccCCcceeecccCCCCCCccccCCHHHH Confidence 99999975568999999998889999999988889999999999999886532221111112237888999999999999 Q NP_000282.1 322 KKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 401 (417) Q Consensus 322 ~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le 401 (417) +.|.+.|++|||||||||||+||.++|++||+++++++++++++++++|+|||||+++++++|+.++++||||||||+|| T Consensus 320 ~~~~~~i~~aktI~wnGP~G~~E~~~f~~GT~~ia~~i~~~~~~~a~~ivGGGdT~~~~~~~g~~~~~s~vSTGGGA~L~ 399 (416) T 3PGK_A 320 KLFAATVAKATVILWNGPPGVFEFEKFAAGTKALLDEVVKSSAAGNTVIIGGGDTATVAKKYGVTDKISHVSTGGGASLE 399 (416) T ss_dssp HHHHHHHSSCSBEEECSCSSCTTSTTSSSHHHHHHHHHHHHTTSSCCEEECSSHHHHHHHHHCCTTCCEECCCSHHHHHH T ss_pred HHHHHHHHhCCEEEEeCCCChhhccccchHHHHHHHHHHHHccCCCeEEEEehhHHHHHHHcCCCCcceEEecChhHHHH Confidence 99999999999999999999999888999999999999763224789999999999999888987889999999999999 Q NP_000282.1 402 LLEGKVLPGVDALSN 416 (417) Q Consensus 402 ~L~G~~LPgl~aL~~ 416 (417) ||+|+.||||++|++ T Consensus 400 ~L~Gk~LPgl~aL~~ 414 (416) T 3PGK_A 400 LLEGKELPGVAFLSE 414 (416) T ss_dssp HHHTCCCHHHHHCSS T ss_pred HHcCCCCChHHHHhc Confidence 999999999999975 No 7 >3Q3V_A Phosphoglycerate kinase (E.C.2.7.2.3); Structural Genomics, Center for Structural; HET: SO4, FMT, PGE; 2.145A {Campylobacter jejuni subsp. jejuni NCTC 11168} Probab=100.00 E-value=3.2e-111 Score=852.34 Aligned_cols=392 Identities=45% Similarity=0.820 Sum_probs=356.7 Template_Neff=6.300 Q NP_000282.1 2 SLSNKLTLDKLDVKGKRVVMRVDFNVPMKN-NQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEP 80 (417) Q Consensus 2 ~~~~~~~i~~~~l~gK~VlvRvD~NVPl~~-~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~ 80 (417) +|+++++++|.|++|||||||+|+|||+++ ++|.|++||++++|||+||+++|| +|||+||+|||+++ ++.+||+| T Consensus 3 ~~~~~~~l~~~~l~gK~vlvR~D~NVPi~~~~~i~dd~RI~~~lpTI~~Ll~~ga-~vil~sHlGrP~~~--~~~~Sl~~ 79 (403) T 3Q3V_A 3 AMSDIISIKDIDLAKKKVFIRCDFNVPQDDFLNITDDRRIRSAIPTIRYCLDNGC-SVILASHLGRPKEI--SSKYSLEP 79 (403) T ss_dssp ---CBCBGGGSCCTTCEEEEECCCCCCBCTTCCBSCCHHHHHHHHHHHHHHHTTC-EEEEECCCSCCSSC--CGGGCSHH T ss_pred cccccccccchhcCCCEEEEEeecCCCcccCCccCCChHHHHHHHHHHHHHHCCC-EEEEEecCCCCccc--CcccCHHH Confidence 578899999889999999999999999975 489999999999999999999999 59999999999865 35899999 Q NP_000282.1 81 VAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDV 160 (417) Q Consensus 81 va~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Di 160 (417) |+++|+++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|+++ +.+|++.||+++|+ T Consensus 80 va~~L~~~l~~~V~f~~~~~g~~~~~~i~~~~~g~i~lLENlRF~~~E~~n---------------~~~fa~~La~l~Di 144 (403) T 3Q3V_A 80 VAKRLARLLDKEIVMAKDVIGEDAKTKAMNLKAGEILLLENLRFEKGETKN---------------DENLAKELASMVQV 144 (403) T ss_dssp HHHHHHHHHTSCCEECSSSSSHHHHHHHHHCCTTCEEECSCGGGSTTGGGT---------------CHHHHHHHHHTCSE T ss_pred HHHHHHHHhCCeeeecCCCCCHHHHHHHHhccCCCEEEEcccccCCcccCC---------------CHHHHHHHHhhchH Confidence 999999999877999999999888888889999999999999999876422 36799999999999 Q NP_000282.1 161 YVNDAFGTAHRAHSSMVGVN--LPQ--KAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMII 236 (417) Q Consensus 161 yVNDAFg~aHR~~aS~~gi~--l~~--~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~ili 236 (417) |||||||++||.|||+++++ +|+ ++||++|++||++|++++++|+||+++|+||+|++||+++|++|+++||.|+| T Consensus 145 yVNDAF~~~HR~hAS~vgi~~~lp~~~s~aG~ll~kEl~~L~~~~~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~ili 224 (403) T 3Q3V_A 145 YINDAFGVCHRAHSSVEAITKFFDEKHKGAGFLLQKEIDFASNLIKHPARPFVAVVGGSKVSGKLQALTNLLPKVDKLII 224 (403) T ss_dssp EEECCGGGTTSCCTTTTGGGGGSCTTSEEECHHHHHHHHHHHHHTTCCCSSEEEEECSSCHHHHHHHHHHHTTTCSEEEE T ss_pred HHhcccccccccCcchhHHHhhcccccccccHHHHHHHHHHHHHHhCCCCCEEEEECCCcHHHHHHHHHHHHHhCCEEEE Confidence 99999999999999999998 663 79999999999999999999999999999999999999999999999999999 Q NP_000282.1 237 GGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDC 316 (417) Q Consensus 237 gG~~a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DI 316 (417) ||+|||+||+|+ |+++|+|++|++..+.|++++++|++++++|++|+|++|.+++..++.. ...+...+|++|+++|| T Consensus 225 gG~~a~tfL~a~-g~~iG~s~~e~~~~~~a~~il~~a~~~~~kI~lP~D~vv~~~~~~~~~~-~~~~~~~i~~~~~~~DI 302 (403) T 3Q3V_A 225 GGGMAFTFLKAL-GYDIGNSLLEEELLEEANKILTKGKNLGVKIYLPVDVVAAPACSQDVPM-KFVPAQEIPNGWMGLDI 302 (403) T ss_dssp CSTTHHHHHHHT-TCCCTTSCCCGGGHHHHHHHHHHHHHTTCEEECCSEEEEESSSSTTSCC-EEEEGGGCCTTCEEEEE T ss_pred cchHHHHHHHHc-CCCCccchhhHHHHHHHHHHHHHHHHhCCeeEeeccEEecCcCCCCCCc-eeechhhcCCCccCccC Confidence 999999999998 8999999999999999999999998999999999999999865322211 11122478889999999 Q NP_000282.1 317 GPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGG 396 (417) Q Consensus 317 Gp~Ti~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgG 396 (417) ||+|++.|.+.|++|||||||||||+||+++|++||+++++++++. ++++|+|||||+++++++|+.++++|||||| T Consensus 303 Gp~Ti~~~~~~i~~aktI~wnGp~G~~E~e~f~~GT~~i~~~i~~~---~a~~ivGGGdT~~~~~~~g~~~~~~~vStGG 379 (403) T 3Q3V_A 303 GPASVRLFKEVISDAQTIWWNGPMGVFEIDKFSKGSIKMSHYISEG---HATSVVGGGDTADVVARAGDADEMTFISTGG 379 (403) T ss_dssp CHHHHHHHHHHHTTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHS---SSEEEEESHHHHHHHHHTTCGGGSSEECCCH T ss_pred CHHHHHHHHHHHhhCCEEEEeCCCCcccccccchHHHHHHHHHHhC---CCeEEEeCHHHHHHHHHcCCCccccEEecch Confidence 9999999999999999999999999999878999999999999762 6899999999999999889888899999999 Q NP_000282.1 397 GASLELLEGKVLPGVDALSN 416 (417) Q Consensus 397 gA~Le~L~G~~LPgl~aL~~ 416 (417) ||+||||+|++||||++|++ T Consensus 380 GA~Le~L~Gk~LPgi~aL~~ 399 (403) T 3Q3V_A 380 GASLELIEGKELPGVKALRS 399 (403) T ss_dssp HHHHHHHTTCCCHHHHTTBC T ss_pred HHHHHHHcCCCCchHHHHhh Confidence 99999999999999999975 No 8 >1PHP_A 3-PHOSPHOGLYCERATE KINASE (PGK) (E.C.2.7.2.3); KINASE; HET: ADP; 1.65A {Geobacillus stearothermophilus} SCOP: c.86.1.1 Probab=100.00 E-value=1.1e-110 Score=847.59 Aligned_cols=387 Identities=48% Similarity=0.853 Sum_probs=355.2 Template_Neff=6.500 Q NP_000282.1 8 TLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKS 87 (417) Q Consensus 8 ~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~~L~~ 87 (417) +++|.|++|||||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++. .+.+||+||+++|++ T Consensus 5 ~l~~~~l~gK~vl~R~D~NVpi~~~~i~d~~RI~~~lpTI~~Ll~~ga-kvvl~sHlGrP~g~~-~~~~Sl~~va~~L~~ 82 (394) T 1PHP_A 5 TIRDVDVRGKRVFCRVDFNVPMEQGAITDDTRIRAALPTIRYLIEHGA-KVILASHLGRPKGKV-VEELRLDAVAKRLGE 82 (394) T ss_dssp BGGGSCCTTCEEEEECCCCCCEETTEESCCHHHHHHHHHHHHHHHTTC-EEEEECCCSCCCSSC-CGGGCSHHHHHHHHH T ss_pred cccccccCCCEEEEEeecCCcccCCCCCCcHHHHHHHHHHHHHHHCCC-cEEEEeccCCCCCCc-chhhhHHHHHHHHHH Confidence 777788999999999999999988899999999999999999999999 599999999998764 468999999999999 Q NP_000282.1 88 LLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFG 167 (417) Q Consensus 88 ~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVNDAFg 167 (417) +|+.+|.|+++|+|+++++.++.+++|+|+||||+|||++|+++ +.+|++.||+++|+||||||| T Consensus 83 ~l~~~v~f~~~~~g~~~~~~i~~~~~g~illLENlRf~~~E~~n---------------~~~fa~~La~l~DiyVnDAF~ 147 (394) T 1PHP_A 83 LLERPVAKTNEAVGDEVKAAVDRLNEGDVLLLENVRFYPGEEKN---------------DPELAKAFAELADLYVNDAFG 147 (394) T ss_dssp HHTSCCEECSCSSSHHHHHHHHTCCTTCEEECCCGGGSHHHHHT---------------CHHHHHHHHTTCSEEEECCGG T ss_pred HhCCCeeecCCCCCHHHHHHHHhccCCCEEEeecccCCCccccC---------------CHHHHHHHHHhccHHHccchh Confidence 99877999999999888888899999999999999999866432 367999999999999999999 Q NP_000282.1 168 TAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFL 245 (417) Q Consensus 168 ~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a~tfl 245 (417) ++||.|||+++++ +| ++||++|++|+++|++++++|+||+++|+||+|++||+++|++|+++||.|++||+|||+|| T Consensus 148 ~~HR~hAS~vgi~~~lp-s~aG~ll~kEl~~L~~~l~~p~rP~v~IlGGaKv~dKi~~i~~ll~~~d~iligG~~a~tfL 226 (394) T 1PHP_A 148 AAHRAHASTEGIAHYLP-AVAGFLMEKELEVLGKALSNPDRPFTAIIGGAKVKDKIGVIDNLLEKVDNLIIGGGLAYTFV 226 (394) T ss_dssp GTTSCCTTTTGGGGTSC-EEECHHHHHHHHHHHHHHHSCCSSEEEEECSSCHHHHHHHHHHHTTTCSEEEECTTHHHHHH T ss_pred HhccccchhhhHHhhhh-hhhcHHHHHHHHHHHHHHhCCCCCEEEEEcCCCHHHHHHHHHHHHhhcCeEEEcchHHHHHH Confidence 9999999999999 67 89999999999999999999999999999999999999999999998999999999999999 Q NP_000282.1 246 KVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYA 325 (417) Q Consensus 246 ~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti~~~~ 325 (417) +|+ |+++|+|++|++..+.|++++++|+.++++|++|+|++|.+.+..++.. ...+.+.+|++|+++||||+|++.|+ T Consensus 227 ~a~-g~~iG~s~~e~~~~~~a~~il~~a~~~~~ki~lP~D~vv~~~~~~~~~~-~~~~~~~i~~~~~~~DIGp~Ti~~~~ 304 (394) T 1PHP_A 227 KAL-GHDVGKSLLEEDKIELAKSFMEKAKEKGVRFYMPVDVVVADRFANDANT-KVVPIDAIPADWSALDIGPKTRELYR 304 (394) T ss_dssp HHT-TCCCTTSCCCGGGHHHHHHHHHHHHHHTCEEECCSEEEEESSSSTTSCE-EEEEGGGCCTTCEEEEECHHHHHHHH T ss_pred HHh-CCCCCcccccHhHHHHHHHHHHHHHHcCCEEEceeeEEEeccccccCCc-eEeecCcCCCCcccccCCHHHHHHHH Confidence 998 8999999999999999999999988899999999999998865322211 11122478899999999999999999 Q NP_000282.1 326 EAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEG 405 (417) Q Consensus 326 ~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le~L~G 405 (417) ++|++|||||||||||+||.++|++||+++++++++++ ++++|+|||||+++++++++.++++||||||||+||||+| T Consensus 305 ~~i~~aktI~wnGP~G~~E~~~f~~GT~~i~~~i~~~~--~a~~viGGGdT~~~~~~~~~~~~~~~vStgGGA~Le~L~G 382 (394) T 1PHP_A 305 DVIRESKLVVWNGPMGVFEMDAFAHGTKAIAEALAEAL--DTYSVIGGGDSAAAVEKFGLADKMDHISTGGGASLEFMEG 382 (394) T ss_dssp HHHHTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHCT--TCEEEECSHHHHHHHHHTTCGGGSSEECSCTHHHHHHHTT T ss_pred HHHHhCCEEEEeCCCCccccchhchHHHHHHHHHHHhc--CCcEEEechHHHHHHHHcCCCccCeEEecchhHHHHHHcC Confidence 99999999999999999998889999999999997632 7899999999998888888877899999999999999999 Q NP_000282.1 406 KVLPGVDALSN 416 (417) Q Consensus 406 ~~LPgl~aL~~ 416 (417) +.||||++|++ T Consensus 383 ~~LPgl~aL~~ 393 (394) T 1PHP_A 383 KQLPGVVALED 393 (394) T ss_dssp CCCHHHHTSCB T ss_pred CCCChhHHhhc Confidence 99999999975 No 9 >1VPE_A PHOSPHOGLYCERATE KINASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER; TRANSFERASE, PHOSPHOGLYCERATE KINASE, THERMOTOGA MARITIMA; HET: 3PG, ANP; 2.0A {Thermotoga maritima} SCOP: c.86.1.1 Probab=100.00 E-value=1.1e-110 Score=848.42 Aligned_cols=392 Identities=49% Similarity=0.875 Sum_probs=356.6 Template_Neff=6.500 Q NP_000282.1 6 KLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVEL 85 (417) Q Consensus 6 ~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~~L 85 (417) |+++++.|++|||||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++. ++.+||+||+++| T Consensus 2 ~~~l~~~~l~gK~vl~R~D~NVP~~~~~i~dd~Ri~~~lpTI~~Ll~~ga-~vil~sHlGrP~g~~-~~~~Sl~~v~~~L 79 (398) T 1VPE_A 2 KMTIRDVDLKGKRVIMRVDFNVPVKDGVVQDDTRIRAALPTIKYALEQGA-KVILLSHLGRPKGEP-SPEFSLAPVAKRL 79 (398) T ss_dssp BCBGGGSCCTTCEEEEECCCCCCEETTEESCCHHHHHHHHHHHHHHHTTC-EEEEECCCSCCCSSC-CGGGCSHHHHHHH T ss_pred CccccccccCCCEEEEEeeCCcccCCCccCCcHHHHHHHHHHHHHHHCCC-cEEEEeccCCCCCCC-CcccCHHHHHHHH Confidence 56777788999999999999999988899999999999999999999999 599999999998764 4689999999999 Q NP_000282.1 86 KSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDA 165 (417) Q Consensus 86 ~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVNDA 165 (417) +++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|+++ +.+|++.||+++|+||||| T Consensus 80 ~~~l~~~V~f~~~~~g~~~~~~i~~~~~g~i~lLENlRf~~~E~~n---------------~~~fa~~La~l~DiyVnDA 144 (398) T 1VPE_A 80 SELLGKEVKFVPAVVGDEVKKAVEELKEGEVLLLENTRFHPGETKN---------------DPELAKFWASLADIHVNDA 144 (398) T ss_dssp HHHHTSCCEEESCSSSHHHHHHHHTCCTTEEEEECCGGGSTHHHHT---------------CHHHHHHHHTTCSEEEECC T ss_pred HHHhCCceeecCCccCHHHHHHHHHhhCCCEEEeeccccCCccccC---------------CHHHHHHHHhcccceeecc Confidence 9999877999999999888888889999999999999999876422 3679999999999999999 Q NP_000282.1 166 FGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFT 243 (417) Q Consensus 166 Fg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a~t 243 (417) |+++||.|||+++++ +| ++||++|++|+++|.+++++|+||+++|+||+|++||+++|++|++++|.|++||+||++ T Consensus 145 F~~~HR~~aS~vgi~~~lp-s~aG~l~~kEl~~L~~~~~~p~~P~v~IlGGaKv~dKi~~i~~ll~k~d~iligG~la~t 223 (398) T 1VPE_A 145 FGTAHRAHASNVGIAQFIP-SVAGFLMEKEIKFLSKVTYNPEKPYVVVLGGAKVSDKIGVITNLMEKADRILIGGAMMFT 223 (398) T ss_dssp GGGTTSCCTTTTGGGGTSC-EEECHHHHHHHHHHHHHHHCCCSSEEEEECSSCHHHHHHHHHHHTTTCSEEEECTTTHHH T ss_pred hhcCCCCcccchHHHhhch-HhhHHHHHHHHHHHHHHhcCCCCCEEEEEcCCCHHHHHHHHHHHHHHCCEEEECchHHHH Confidence 999999999999998 66 899999999999999999999999999999999999999999999988999999999999 Q NP_000282.1 244 FLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKK 323 (417) Q Consensus 244 fl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti~~ 323 (417) ||+|+ |+++|+|++|++..+.|++++++|++++++|+||+|++|.+++..+.....+...+.+|++|+++||||+|++. T Consensus 224 fl~a~-g~~vG~S~~e~~~~~~a~~il~~a~~~~~kI~lP~D~vv~~~~~~~~~~~~~~~~~~ip~~~~i~DIGp~Ti~~ 302 (398) T 1VPE_A 224 FLKAL-GKEVGSSRVEEDKIDLAKELVEKAKEKGVEIVLPVDAVIAQKIEPGVEKKVVRIDDGIPEGWMGLDIGPETIEL 302 (398) T ss_dssp HHHHT-SCCCTTSCCCGGGHHHHHHHHHHHHHTTCEEECCSEEEEESSCSTTCCCEEEETTTCCCTTCEEEEECHHHHHH T ss_pred HHHHh-CCCccCCcccHHHHHHHHHHHHHHHHcCCEEEceeeeEeccCCCCCCcceEEecccCCCCCcccCCCCHHHHHH Confidence 99998 88999999999999999999999989999999999999998653322111111123788899999999999999 Q NP_000282.1 324 YAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELL 403 (417) Q Consensus 324 ~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le~L 403 (417) |.++|++|||||||||||+||+++|++||+++++++++++++++++|+|||||+++++++|+.++++||||||||+|||| T Consensus 303 ~~~~I~~aktI~wnGP~G~~E~e~f~~GT~~i~~ai~~~~~~~a~sivGGGdT~~~~~~~g~~~~~s~vStgGGA~Le~L 382 (398) T 1VPE_A 303 FKQKLSDAKTVVWNGPMGVFEIDDFAEGTKQVALAIAALTEKGAITVVGGGDSAAAVNKFGLEDKFSHVSTGGGASLEFL 382 (398) T ss_dssp HHHHHTTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHHHHTTCEEEEESHHHHHHHHHTTCGGGSSEEESCHHHHHHHH T ss_pred HHHHHhcCCEEEEeCCCCcccCcccchhHHHHHHHHHHhhhCCcEEEEcchHHHHHHHHcCCCCcceEEEcchHHHHHHH Confidence 99999999999999999999887899999999999976322478999999999998888888788999999999999999 Q NP_000282.1 404 EGKVLPGVDALSN 416 (417) Q Consensus 404 ~G~~LPgl~aL~~ 416 (417) +|++||||++|++ T Consensus 383 ~G~~LPgl~aL~~ 395 (398) T 1VPE_A 383 EGKELPGIASMRI 395 (398) T ss_dssp TSSCCHHHHTSCB T ss_pred cCCCCCcHHHhhh Confidence 9999999999975 No 10 >4FEY_A Phosphoglycerate kinase (E.C.2.7.2.3); Structural Genomics, NIAID, National Institute; HET: ADP; 2.3A {Francisella tularensis subsp. tularensis} Probab=100.00 E-value=5.5e-110 Score=841.97 Aligned_cols=388 Identities=44% Similarity=0.740 Sum_probs=352.5 Template_Neff=6.400 Q NP_000282.1 2 SLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPV 81 (417) Q Consensus 2 ~~~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~v 81 (417) .||++++++|.|++||+||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++.+||+|| T Consensus 2 ~~~~~~~l~~~~l~gK~vl~RvD~NVPl~~~~i~dd~RI~~~lpTI~~Ll~~ga-~vvl~sHlGrP~~~~~~~~~Sl~pv 80 (395) T 4FEY_A 2 NAMSFLTLKDVDLKDKKVLVRVDFNVPVKDGKVTSKVRIEAAIPTIQYILDQGG-AVILMSHLGRPTEGEYDSQFSLEPV 80 (395) T ss_dssp --CCSCBGGGSCCTTCEEEEECCCCCCEETTEESCCHHHHHTHHHHHHHHHHTC-EEEEECCCSCCCTTSCCGGGCSHHH T ss_pred CcccccccccccCCCCEEEEEeeCCCcccCCccCCcHHHHHHHHHHHHHHHCCC-EEEEEeecCCCCCCCCCcccCHHHH Confidence 478899999999999999999999999988899999999999999999999999 5999999999987522458999999 Q NP_000282.1 82 AVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVY 161 (417) Q Consensus 82 a~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Diy 161 (417) +++|+++|+.+|.|+++|++. .++++|+|+||||+|||++|+++ +.+|+++||+++|+| T Consensus 81 a~~L~~~l~~~v~f~~d~~~~------~~~~~g~illLENlRf~~~E~~~---------------~~~fa~~La~l~Diy 139 (395) T 4FEY_A 81 AKALSEIINKPVKFAKDWLDG------VDVKAGEIVMCENVRFNSGEKKS---------------TDDLSKKIASLGDVF 139 (395) T ss_dssp HHHHHHHHCSCEEEESSTTTC------CCCCTTCEEEECCGGGSTTTTTT---------------CHHHHHHHHHTCSEE T ss_pred HHHHHHHhCCceeecccccCC------CCCCCCeEEEEecccccCcccCC---------------chHHHHHHHhcchHh Confidence 999999998779999999884 27889999999999999876421 367999999999999 Q NP_000282.1 162 VNDAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGG 239 (417) Q Consensus 162 VNDAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~ 239 (417) |||||+++||.|||+++++ +|+++||++|++|+++|++++++|+||+++|+||+|++||+++|++|+++||.|++||+ T Consensus 140 VnDAF~~~HR~~aS~vgi~~~lp~s~aG~l~~kEl~~L~~~~~~p~~P~v~IlGGaKv~dKi~~i~~Ll~~~d~iligG~ 219 (395) T 4FEY_A 140 VMDAFATAHRAQASTYGVAKYIPVACAGILLTNEIQALEKALKSPKKPMAAIVGGSKVSTKLSVLNNLLDKVEILIVGGG 219 (395) T ss_dssp EECCGGGTTSCCCCCCCHHHHSSEEEECHHHHHHHHHHHHHHTSCCSSEEEEEEESCHHHHHHHHHHHTTTCSEEEEEEH T ss_pred hhhcHhHcchhccccccccccCCcchHhHHHHHHHHHHHHHHhCCCCCeEEEECCCcHHHHHHHHHHHHHhCCEEEeccH Confidence 9999999999999999998 66689999999999999999999999999999999999999999999999999999999 Q NP_000282.1 240 MAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPE 319 (417) Q Consensus 240 ~a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~ 319 (417) ||++||+|+ |+++|+|++|++..+.|++++++|+.++++|++|+|++|.+++..+.... ......+|++|+++||||+ T Consensus 220 ~a~tfl~a~-g~~vg~s~~e~~~~~~a~~il~~a~~~~~ki~lP~D~~v~~~~~~~~~~~-~~~~~~ip~~~~~~DIGp~ 297 (395) T 4FEY_A 220 IANTFIKAE-GFDVGNSLYEQDLVAEATEILAKAKALGVNIPVPVDVRVAKEFSENAQAI-IKKVSDVVADEMILDIGPE 297 (395) T ss_dssp HHHHHHHHT-TCCCTTCCCCGGGHHHHHHHHHHHHHTTCBCCCCSEEEEESSSSTTCCCE-EEEGGGCCTTCEEEEECHH T ss_pred HHHHHHHHc-CCccCCcccchhHHHHHHHHHHHHHHhCCceeeeeeEEecccccccccce-EeeHHHCCCCcEeccCCHH Confidence 999999998 88999999999889999999999999999999999999998754322211 1112478899999999999 Q NP_000282.1 320 SSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGAS 399 (417) Q Consensus 320 Ti~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~ 399 (417) |++.|.+.|++|||||||||||+||.++|++||+++++++++. ++++|+|||||+++++++|+.++++||||||||+ T Consensus 298 Ti~~~~~~i~~aktI~wnGP~G~~E~~~f~~GT~~i~~aia~~---~a~~ivGGGdT~~~~~~~g~~~~~s~vStgGGA~ 374 (395) T 4FEY_A 298 SQKIIAELLKSANTILWNGPVGVFEFDNFAEGTKALSLAIAQS---HAFSVAGGGDTIAAIEKFGIKDQVSYISTAGGAF 374 (395) T ss_dssp HHHHHHHHHHHCSEEEEECCSSCTTSGGGCHHHHHHHHHHHHH---CSEEEEESHHHHHHHHHTTCSTTSSEEECCSHHH T ss_pred HHHHHHHHHHhCCEEEEcCCCCcccccccChHHHHHHHHHHhC---CCcEEEechHHHHHHHHcCCCcCcEEEEcchHHH Confidence 9999999999999999999999998888999999999999762 6899999999998888889888999999999999 Q NP_000282.1 400 LELLEGKVLPGVDALSN 416 (417) Q Consensus 400 Le~L~G~~LPgl~aL~~ 416 (417) ||||+|+.||||++|++ T Consensus 375 Le~L~G~~LPgleaL~~ 391 (395) T 4FEY_A 375 LEFLEGKKLPAIEILKE 391 (395) T ss_dssp HHHHTTCCCHHHHHHHH T ss_pred HHHHcCCCCchHHHHHH Confidence 99999999999999975 No 11 >1V6S_B Phosphoglycerate kinase (E.C.2.7.2.3); phosphoglycerate kinase, Thermus thermophilus, RIKEN; HET: GOL; 1.5A {Thermus thermophilus} SCOP: c.86.1.1 Probab=100.00 E-value=1.2e-109 Score=838.81 Aligned_cols=386 Identities=44% Similarity=0.774 Sum_probs=350.7 Template_Neff=6.500 Q NP_000282.1 7 LTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELK 86 (417) Q Consensus 7 ~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~~L~ 86 (417) ++++|.|++|||||||+|+|||+++++|.|++||++++|||+||++ ++++|||+||+|||+++ ++.+||+||+++|+ T Consensus 2 ~~l~d~~l~gK~vl~R~D~NVPi~~~~i~d~~RI~~~lpTI~~Ll~-~~~~vvl~sHlGrP~~~--~~~~Sl~pva~~L~ 78 (390) T 1V6S_B 2 RTLLDLDPKGKRVLVRVDYNVPVQDGKVQDETRILESLPTLRHLLA-GGASLVLLSHLGRPKGP--DPKYSLAPVGEALR 78 (390) T ss_dssp CBGGGCCCTTCEEEEECCCCCCEETTEESCCHHHHHHHHHHHHHHH-TTCEEEEECCCSCCSSC--CGGGCSHHHHHHHH T ss_pred CCccccCCCCCEEEEEeeccccccCCccCCcHHHHhHHHHHHHHHh-CCCeEEEEeccCCCCCC--CcccchHHHHHHHH Confidence 5677788999999999999999998899999999999999999999 54359999999999865 35799999999999 Q NP_000282.1 87 SLLGKDVLFLKDCVG-PEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDA 165 (417) Q Consensus 87 ~~l~~~v~f~~~~~~-~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVNDA 165 (417) ++|+. |.|++++++ +++.+.++.+++|+|+||||+|||++|+++ +.+|+++||+++|+||||| T Consensus 79 ~~l~~-v~f~~~~~~~~~~~~~i~~~~~g~i~lLENlRf~~~E~~n---------------~~~fa~~La~l~DiyVNDA 142 (390) T 1V6S_B 79 AHLPE-ARFAPFPPGSEEARREAEALRPGEVLLLENVRFEPGEEKN---------------DPELSARYARLGEAFVLDA 142 (390) T ss_dssp TTCTT-EEECCSCTTSHHHHHHHHTCCTTCEEECCCGGGSTTTTTT---------------CHHHHHHHGGGCSEEEECC T ss_pred HHCCC-cEeCCCCCCcHHHHHHHHHcCCCCEEEEeccCCCCCcccC---------------CHHHHHHHHhhcceEeeec Confidence 99986 899998888 677778889999999999999999866422 3679999999999999999 Q NP_000282.1 166 FGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFT 243 (417) Q Consensus 166 Fg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a~t 243 (417) ||++||.|||+++++ +| ++||++|++|+++|++++++|+||+++|+||+|++||+++|++|++++|.|++||+|||+ T Consensus 143 F~~~HR~hAS~vgi~~~lp-s~aG~ll~kEl~~L~~~l~~p~~P~v~IlGGaKv~dKi~~i~~Ll~~~D~IligG~~a~t 221 (390) T 1V6S_B 143 FGSAHRAHASVVGVARLLP-AYAGFLMEKEVRALSRLLKDPERPYAVVLGGAKVSDKIGVIESLLPRIDRLLIGGAMAFT 221 (390) T ss_dssp GGGTTSCCCCCCCGGGTSC-EEECHHHHHHHHHHHHTTSCCCSSEEEEECCSCGGGTHHHHHHHGGGCSEEEECSTHHHH T ss_pred hhhcCcccchhhHHHhhHH-hhccHHHHHHHHHHHHHHcCCCCCEEEEEcCCCHHHHHHHHHHHHHHCCEEEEcchHHHH Confidence 999999999999999 67 899999999999999999999999999999999999999999999988999999999999 Q NP_000282.1 244 FLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKK 323 (417) Q Consensus 244 fl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti~~ 323 (417) ||+|+ |+++|+|++|++..+.|++++++|+.++++|++|+|++|.+.+...... ...+...+|++|+++||||+|++. T Consensus 222 fL~a~-g~~ig~s~~e~~~~~~a~~il~~a~~~~~ki~lP~D~vv~~~~~~~~~~-~~~~~~~ip~~~~~~DIGp~Ti~~ 299 (390) T 1V6S_B 222 FLKAL-GGEVGRSLVEEDRLDLAKDLLGRAEALGVRVYLPEDVVAAERIEAGVET-RVFPARAIPVPYMGLDIGPKTREA 299 (390) T ss_dssp HHHHT-TCBCTTCCCCGGGHHHHHHHHHHHHHTTCEEECCSEEEEESSCCTTCCC-EEEETTBCCTTCEEEEECHHHHHH T ss_pred HHHHc-CCCccccccchhHHHHHHHHHHHHHHhCCeEEceeceeeccccccCCce-EEecCccCCCCcccccCCHHHHHH Confidence 99998 8899999999999999999999888899999999999998865322111 112224788899999999999999 Q NP_000282.1 324 YAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELL 403 (417) Q Consensus 324 ~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le~L 403 (417) |+++|++|||||||||||+||+++|++||+++++++++++ ++++|+|||||+++++++|+.++++||||||||+|||| T Consensus 300 ~~~~i~~aktI~wnGp~G~~E~~~f~~GT~~i~~~i~~~~--~a~~iiGGGdT~~~~~~~g~~~~~~~vStgGGA~L~~L 377 (390) T 1V6S_B 300 FARALEGARTVFWNGPMGVFEVPPFDEGTLAVGQAIAALE--GAFTVVGGGDSVAAVNRLGLKERFGHVSTGGGASLEFL 377 (390) T ss_dssp HHHHHTTCSEEEEESCSSCTTSTTTTHHHHHHHHHHHHCS--SCEEEEESHHHHHHHHHTTCGGGSSEECCSSSCHHHHH T ss_pred HHHHHhcCCEEEEeCCCcccCCCCcchHHHHHHHHHHHcc--CCEEEEeCHHHHHHHHHcCCCCcceEEecchHHHHHHH Confidence 9999999999999999999988889999999999997632 78999999999999999898889999999999999999 Q NP_000282.1 404 EGKVLPGVDALSN 416 (417) Q Consensus 404 ~G~~LPgl~aL~~ 416 (417) +|+.||||++|++ T Consensus 378 ~g~~LPgl~aL~~ 390 (390) T 1V6S_B 378 EKGTLPGLEVLEG 390 (390) T ss_dssp HHSCCHHHHTTCC T ss_pred hcCCCCcchhccC Confidence 9999999999974 No 12 >3ZLB_A PHOSPHOGLYCERATE KINASE (E.C.2.7.2.3); TRANSFERASE; HET: ANP, GOL; 1.78A {STREPTOCOCCUS PNEUMONIAE} Probab=100.00 E-value=1.6e-109 Score=839.96 Aligned_cols=394 Identities=46% Similarity=0.789 Sum_probs=353.2 Template_Neff=6.500 Q NP_000282.1 4 SNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAV 83 (417) Q Consensus 4 ~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~ 83 (417) |++++++|.|++|||||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++.+||+||++ T Consensus 1 ~~~~~l~~~~l~gK~vlvR~D~NVPi~~~~i~dd~RI~~~lpTI~~Ll~~ga-kvil~sHlGRP~g~~~~~~~Sl~pva~ 79 (398) T 3ZLB_A 1 MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYIIEQGG-RAILFSHLGRVKEESDKAGKSLAPVAA 79 (398) T ss_dssp CCBCBGGGSCCTTCEEEEECCCCCCEETTEESCCHHHHHHHHHHHHHHHTTC-EEEEECCCSCCCSGGGSTTCCSHHHHH T ss_pred CCccccccccCCCCEEEEEeeCCCccCCCCcCCChHHHHHHHHHHHHHHCCC-eEEEEeecCccCCcccccCcchHHHHH Confidence 4677888888999999999999999998899999999999999999999999 599999999998753134799999999 Q NP_000282.1 84 ELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGD-VYV 162 (417) Q Consensus 84 ~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~D-iyV 162 (417) +|+++|+.+|.|+++|+|+++++.++.+++|+|+||||+|||++|... +. .++.+|+++||+++| +|| T Consensus 80 ~L~~~l~~~v~f~~~~~g~~~~~~i~~~~~g~i~lLENlRf~~~E~~~-e~----------~n~~~fa~~La~l~d~iyV 148 (398) T 3ZLB_A 80 DLAAKLGQDVVFPGVTRGAELEAAINALEDGQVLLVENTRYEDVDGKK-ES----------KNDPELGKYWASLGDGIFV 148 (398) T ss_dssp HHHHHHTSCEECCSCSSSHHHHHHHHTCCTTCEEECCCGGGGGTTTCT-TT----------TTCHHHHHHHHHTSSSEEE T ss_pred HHHHHhCCceeCCCCCCCHHHHHHHHhccCCCEEEEecccccCCCCCc-cc----------cccHHHHHHHHhcCCcEEE Confidence 999999877999999999888888899999999999999999865211 10 114789999999988 999 Q NP_000282.1 163 NDAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGM 240 (417) Q Consensus 163 NDAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~ 240 (417) ||||+++||.|||+++++ +|+++||++|++||++|++++++|+||+++|+||+|++||+++|++|++++|.|++||+| T Consensus 149 NDAF~~~HR~hAS~vgi~~~lp~s~aG~ll~kEl~~L~~~l~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~iligG~~ 228 (398) T 3ZLB_A 149 NDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGM 228 (398) T ss_dssp ECCGGGTTSCCCCCCCHHTTSSEEEECHHHHHHHCCCCCHHHSCCSSEEEEECSSCSTTTHHHHHHHHHHCSEEEECTTH T ss_pred ecchhhcccccchhhhhhHhhchHhHHHHHHHHHHHHHHHHHCCCCCEEEEEcCCCHHHHHHHHHHHHHHhCceEeCchH Confidence 999999999999999999 666899999999999999999999999999999999999999999999988999999999 Q NP_000282.1 241 AFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPES 320 (417) Q Consensus 241 a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~T 320 (417) ||+||+|+ |+++|+|++|++..+.|++++++ ++++|++|+|++|.+.+...... ...+...+|++|+++||||+| T Consensus 229 a~tfL~a~-g~~ig~S~~e~~~~~~a~~ll~~---~~~ki~lP~D~vv~~~~~~~~~~-~~~~~~~i~~~~~~~DIGp~T 303 (398) T 3ZLB_A 229 TYTFYKAQ-GIEIGNSLVEEDKLDVAKALLEK---ANGKLILPVDSKEANAFAGYTEV-RDTEGEAVSEGFLGLDIGPKS 303 (398) T ss_dssp HHHHHHHT-TCCCTTCCCCGGGHHHHHHHHHH---STTCEECCSCEEEESSSSSCSCE-EECSSSCCCTTCEEEEECHHH T ss_pred HHHHHHHc-CCcccCcccccchHHHHHHHHHH---cCCceEeeccchhhhcccCCCce-eeeccccccCCCeeecCCHHH Confidence 99999998 88999999999888999999875 47899999999998864332111 111124788899999999999 Q NP_000282.1 321 SKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASL 400 (417) Q Consensus 321 i~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~L 400 (417) ++.|.+.|++|||||||||||+||.++|++||+++++++++++ ++++|+|||||+++++++|+.++|+||||||||+| T Consensus 304 i~~~~~~I~~aktI~wnGP~G~~E~~~f~~GT~~i~~~i~~~~--~a~~iiGGGdT~~~~~~~g~~~~~s~vStgGGA~L 381 (398) T 3ZLB_A 304 IAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQP--GVKSIIGGGDSAAAAINLGRADKFSWISTGGGASM 381 (398) T ss_dssp HHHHHHHHTTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHTST--TCEEEECCHHHHHHHHHTTCGGGSSEECCCTHHHH T ss_pred HHHHHHHHhcCCEEEEeCCCCccCCccccchHHHHHHHHHcCC--CCcEEEecccHHHHHHHcCCCCCCeEEEcchHHHH Confidence 9999999999999999999999998889999999999997632 78999999999988888888778999999999999 Q NP_000282.1 401 ELLEGKVLPGVDALSN 416 (417) Q Consensus 401 e~L~G~~LPgl~aL~~ 416 (417) |||+|+.||||++|++ T Consensus 382 e~L~G~~LPgl~aL~~ 397 (398) T 3ZLB_A 382 ELLEGKVLPGLAALTE 397 (398) T ss_dssp HHHTTCCCHHHHTSCB T ss_pred HHHcCCCCchHHHhhc Confidence 9999999999999975 No 13 >4EHJ_A Phosphoglycerate kinase (E.C.2.7.2.3); Structural Genomics, Center for Structural; HET: MSE; 2.71A {Francisella tularensis subsp. tularensis} Probab=100.00 E-value=2e-109 Score=837.07 Aligned_cols=386 Identities=44% Similarity=0.744 Sum_probs=350.7 Template_Neff=6.400 Q NP_000282.1 4 SNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAV 83 (417) Q Consensus 4 ~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~ 83 (417) |++++++|.|++||+||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++.+||+||++ T Consensus 1 ~~~~~l~~~~l~gK~vl~R~D~NVpl~~~~i~dd~RI~~~lpTI~~Ll~~ga-~vvl~sHlGrP~~~~~~~~~Sl~pva~ 79 (392) T 4EHJ_A 1 MSFLTLKDVDLKDKKVLVRVDFNVPVKDGKVTSKVRIEAAIPTIQYILDQGG-AVILMSHLGRPTEGEYDSQFSLEPVAK 79 (392) T ss_dssp -CCCBGGGSCCTTCEEEEECCCCCCEETTEESCCHHHHHHHHHHHHHHHTTC-EEEEECCCSCCCTTCCCGGGCSHHHHH T ss_pred CCccccccccCCCCEEEEEeeCCCcccCCccCCcHHHHHHHHHHHHHHHCCC-eEEEEeecCCCCCCCCCcccCHHHHHH Confidence 4578888888999999999999999988899999999999999999999999 699999999998752245899999999 Q NP_000282.1 84 ELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVN 163 (417) Q Consensus 84 ~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVN 163 (417) +|+++|+.+|.|+++|++. .++++|+|+||||+|||++|+++ +.+|+++||+++|+||| T Consensus 80 ~L~~~l~~~v~f~~d~~~~------~~~~~g~illLENlRf~~~E~~~---------------~~~fa~~La~~~DiyVn 138 (392) T 4EHJ_A 80 ALSEIINKPVKFAKDWLDG------VDVKAGEIVMCENVRFNSGEKKS---------------TDDLSKKIASLGDVFVM 138 (392) T ss_dssp HHHHHHTSCEEEETTCTTC------CCCCTTCEEEECCGGGSTTTTTT---------------CHHHHHHHHHTCSEEEE T ss_pred HHHHHhCCceeecccccCC------CCCCCCeEEEEecccccCcccCC---------------chHHHHHHHhcchHhhh Confidence 9999998779999999885 27889999999999999876421 36799999999999999 Q NP_000282.1 164 DAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMA 241 (417) Q Consensus 164 DAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a 241 (417) |||+++||.|||+++++ +|+++||++|++|+++|++++++|+||+++|+||+|++||+++|++|+++||.|++||+|| T Consensus 139 DAF~~~HR~~aS~vgi~~~lp~s~aG~l~~kEl~~L~~~~~~p~~P~v~IiGGaKv~dKi~~i~~Ll~~~D~IligG~~a 218 (392) T 4EHJ_A 139 DAFATAHRAQASTYGVAKYIPVACAGILLTNEIQALEKALKSPKKPMAAIVGGSKVSTKLSVLNNLLDKVEILIVGGGIA 218 (392) T ss_dssp CCGGGTTSCCCCCCCHHHHSSEEEECHHHHHHHHHHHHHHTSCCSSEEEEEECSCHHHHHHHHHHHTTTCSEEEEETHHH T ss_pred hcHhHccccccccccccccCCcchHhHHHHHHHHHHHHHHhCCCCCEEEEECCCcHHHHHHHHHHHHHhCCEEEeccHHH Confidence 99999999999999999 6668999999999999999999999999999999999999999999999999999999999 Q NP_000282.1 242 FTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESS 321 (417) Q Consensus 242 ~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 321 (417) ++||+|+ |+++|+|++|++..+.|++++++|+.++++|++|+|++|.+++..+.... ......+|++|+++||||+|+ T Consensus 219 ~tfl~a~-g~~vg~s~~e~~~~~~a~~il~~a~~~~~kI~lP~D~~v~~~~~~~~~~~-~~~~~~i~~~~~~~DIGp~T~ 296 (392) T 4EHJ_A 219 NTFIKAE-GFDVGNSLYEQDLVAEATEILAKAKALGVNIPVPVDVRVAKEFSENAQAI-IKKVSDVVADEMILDIGPESQ 296 (392) T ss_dssp HHHHHHT-TCCCTTCSCCGGGHHHHHHHHHHHHHHTCBCCCCSEEEEESSCSTTCCCE-EEEGGGCCTTCEEEEECHHHH T ss_pred HHHHHHc-CCccCCcccchhHHHHHHHHHHHHHHhCCceeeeeeEEecccccccccce-EeeHHHCCCCcEeccCCHHHH Confidence 9999998 88999999999888999999999988999999999999998754322211 111247888999999999999 Q NP_000282.1 322 KKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 401 (417) Q Consensus 322 ~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le 401 (417) +.|++.|++|||||||||||+||.++|++||+++++++++. ++++|+|||||+++++++|+.++++||||||||+|| T Consensus 297 ~~~~~~i~~aktI~wnGp~G~~E~~~f~~GT~~i~~ai~~~---~a~~vvGGGdT~~~~~~~g~~~~~~~vStgGGA~Le 373 (392) T 4EHJ_A 297 KIIAELLKSANTILWNGPVGVFEFDNFAEGTKALSLAIAQS---HAFSVAGGGDTIAAIEKFGIKDQVSYISTAGGAFLE 373 (392) T ss_dssp HHHHHHHHHCSEEEEECCSSCTTSGGGCHHHHHHHHHHHHC---CSEEEECSHHHHHHHHHHTCGGGSSEECCCSHHHHH T ss_pred HHHHHHHHhCCEEEEcCCCCcccccccChHHHHHHHHHHhC---CCcEEEechHHHHHHHHcCCCcCcEEEEcchHHHHH Confidence 99999999999999999999998888999999999999762 689999999999888888988899999999999999 Q NP_000282.1 402 LLEGKVLPGVDALSN 416 (417) Q Consensus 402 ~L~G~~LPgl~aL~~ 416 (417) ||+|+.||||++|++ T Consensus 374 ~L~G~~LPgl~aL~~ 388 (392) T 4EHJ_A 374 FLEGKKLPAIEILKE 388 (392) T ss_dssp HHTTCCCHHHHHHHH T ss_pred HHcCCCCchHHHHHH Confidence 999999999999975 No 14 >16PK_A 3-PHOSPHOGLYCERATE KINASE, 1,1,5,5-TETRAFLUOROPHOSPHOPENTYLPHOSPHONIC ACID ADENYLATE; KINASE, PHOSPHOGLYCERATE, TERNARY COMPLEX, GLYCOLYSIS; HET: EPE, BIS; 1.6A {Trypanosoma brucei} SCOP: c.86.1.1 Probab=100.00 E-value=4.2e-109 Score=840.30 Aligned_cols=395 Identities=47% Similarity=0.803 Sum_probs=351.6 Template_Neff=6.400 Q NP_000282.1 6 KLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPM------------- 72 (417) Q Consensus 6 ~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~------------- 72 (417) ++++++.|++|||||||+|+|||+++++|.|++||++++|||+||++ +|++|||+||+|||+++.. T Consensus 2 ~~~l~~~~l~gK~vlvR~D~NVPl~~~~i~dd~RI~~~lpTI~~Ll~-~~~kvil~sHlGRP~g~~~~~~~~~~~~~~~~ 80 (415) T 16PK_A 2 KKSINECDLKGKKVLIRVDFNVPVKNGKITNDYRIRSALPTLKKVLT-EGGSCVLMSHLGRPKGIPMAQAGKIRSTGGVP 80 (415) T ss_dssp BCBGGGSCCTTCEEEEEECCCCCEETTEESCCHHHHHHHHHHHHHHH-TTCEEEEECCCSCCCCBCGGGHHHHHHTTCCT T ss_pred CCccchhhcCCCEEEEEeeCCCcccCCccCCcHHHHHHHHHHHHHHH-cCCeEEEEeecCCCCCCChhhccccccCCCCC Confidence 56777788999999999999999987899999999999999999999 5545999999999986320 Q NP_000282.1 73 --PDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAF 150 (417) Q Consensus 73 --~~~~Sl~~va~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~f 150 (417) .+.+||+||+++|+++|+.+|.|+++|+| +.+.++.+++|+|+||||+|||++|++++ + +++.+| T Consensus 81 ~~~~~~Sl~pva~~L~~~l~~~V~f~~~~~~--~~~~i~~~~~g~i~lLENlRF~~~E~~~~-~----------~~~~~f 147 (415) T 16PK_A 81 GFQQKATLKPVAKRLSELLLRPVTFAPDCLN--AADVVSKMSPGDVVLLENVRFYKEEGSKK-A----------KDREAM 147 (415) T ss_dssp TCCGGGCSHHHHHHHHHHHTSCCEEESCTTS--CHHHHHTCCTTCEEEECCGGGBGGGGCSS-H----------HHHHHH T ss_pred CcchhccHHHHHHHHHHHhCCcceeCCCcCC--HHHHHHhCCCCCEEEEecccccccccccc-c----------ccHHHH Confidence 12689999999999999867999999998 45567799999999999999998765221 0 113789 Q NP_000282.1 151 RASLSKLGDVYVNDAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNML 228 (417) Q Consensus 151 a~~LA~l~DiyVNDAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll 228 (417) +++||+++|+|||||||++||.|||+++++ +|+++||++|++||++|.+++++|+||+++|+||+|++||+++|++|+ T Consensus 148 a~~La~l~DiyVNDAF~~~HR~hAS~vgi~~~lp~s~aG~ll~kEl~~L~~~~~~p~rP~v~IlGGaKv~dKi~~i~~Ll 227 (415) T 16PK_A 148 AKILASYGDVYISDAFGTAHRDSATMTGIPKILGNGAAGYLMEKEISYFAKVLGNPPRPLVAIVGGAKVSDKIQLLDNML 227 (415) T ss_dssp HHHHHTTCSEEEEECGGGTTSCCCCCCCHHHHHTCCEECHHHHHHHHHHHHHHSCCCSSEEEEECSSCSGGGHHHHHHHG T ss_pred HHHHHhccCeEEeechhhcccCcchhccHhHhhcccchHHHHHHHHHHHHHHHcCCCCCeEEEEcCCCHHHHHHHHHHHH Confidence 999999999999999999999999999999 665899999999999999999999999999999999999999999999 Q NP_000282.1 229 DKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIP 308 (417) Q Consensus 229 ~~~D~iligG~~a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~ 308 (417) +++|.|+|||+|||+||+|+ |+++|+|++|++..+.|++++++|+.++++|++|+|++|.+++...... ...+.+.+| T Consensus 228 ~~~D~IligG~~a~tfl~a~-g~~vG~s~~e~~~~~~a~~ll~~a~~~~~kI~lP~D~~v~~~~~~~~~~-~~~~~~~i~ 305 (415) T 16PK_A 228 QRIDYLLIGGAMAYTFLKAQ-GYSIGKSKCEESKLEFARSLLKKAEDRKVQVILPIDHVCHTEFKAVDSP-LITEDQNIP 305 (415) T ss_dssp GGCSEEEECTTHHHHHHHHH-TCCCTTCCCCGGGHHHHHHHHHHHHHTTCEEECCSSEEEESSSSCCSSC-EECSSSCCC T ss_pred HHcCEEEeCchHHHHHHHHc-CCcccccccchhHHHHHHHHHHHHHhcCCEEEceeceeeccccCCCCCC-ceeccccCC Confidence 98899999999999999998 8999999999999999999999888899999999999999875321111 111224788 Q NP_000282.1 309 AGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKAT-SRGCITIIGGGDTATCCAKWNTED 387 (417) Q Consensus 309 ~~~~~~DIGp~Ti~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~-~~~~~~ivGGGdT~~~~~~~g~~~ 387 (417) ++|+++||||+|++.|++.|++|||||||||||+||+++|++||+++++++++++ .+++++|+|||||+++++++|+.+ T Consensus 306 ~~~~~~DIGp~Ti~~~~~~i~~aktI~wnGp~G~~E~~~f~~GT~~i~~~l~~~~~~~~a~~vvGGGdT~~~~~~~~~~~ 385 (415) T 16PK_A 306 EGHMALDIGPKTIEKYVQTIGKCKSAIWNGPMGVFEMVPYSKGTFAIAKAMGRGTHEHGLMSIIGGGDSASAAELSGEAK 385 (415) T ss_dssp TTCEEEEECHHHHHHHHHHHTTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHHHHHHCCEEEECSHHHHHHHHHTTCTT T ss_pred CCCcccccCHHHHHHHHHHHHcCCEEEEeCCCccccCCccccchHHHHHHHHhhcccCCceEEEcchhHHHHHHHhCCcc Confidence 8999999999999999999999999999999999998889999999999997632 247899999999998888888888 Q NP_000282.1 388 KVSHVSTGGGASLELLEGKVLPGVDALSN 416 (417) Q Consensus 388 ~~~~vStgGgA~Le~L~G~~LPgl~aL~~ 416 (417) +++||||||||+||||+|++||||++|++ T Consensus 386 ~~s~vStgGGA~Le~L~Gk~LPgl~aL~~ 414 (415) T 16PK_A 386 RMSHVSTGGGASLELLEGKTLPGVTVLDD 414 (415) T ss_dssp TSSEECSCHHHHHHHHTTCCCHHHHTSCB T ss_pred cCeEEEcchHHHHHHHcCCCCCchHhccc Confidence 89999999999999999999999999975 No 15 >3OZ7_B Phosphoglycerate kinase (E.C.2.7.2.3); Phosphoglycerate kinase, Transferase, ATP Binding; HET: SO4; 2.7A {Plasmodium falciparum} Probab=100.00 E-value=4.5e-109 Score=840.55 Aligned_cols=413 Identities=61% Similarity=0.995 Sum_probs=361.2 Template_Neff=6.400 Q NP_000282.1 3 LSNKLTLDKL-DVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPV 81 (417) Q Consensus 3 ~~~~~~i~~~-~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~v 81 (417) ...++++.+. |++||+||||+|+|||+++++|.|++||++++|||+||+++||++|||+||+|||+++. ++.+||+|| T Consensus 4 ~~~~~~~~~~~~l~gk~vlvR~D~NVPi~~~~i~d~~Ri~~~lpTI~~Ll~~gak~vvl~sHlGRP~g~~-~~~~Sl~~v 82 (417) T 3OZ7_B 4 LGNKLSISDLKDIKNKKVLVRVDFNVPIENGIIKDTNRITATLPTINHLKKEGASKIILISHCGRPDGLR-NEKYTLKPV 82 (417) T ss_dssp TTSCCBGGGCCCCTTCEEEEEECCCCCEETTEESCCHHHHTTHHHHHHHHHTTCSEEEEECCCSCCTTSC-CGGGCCSHH T ss_pred CCCCCChhhhhhcCCCEEEEEEeCCCcccCCccCCChhHHhHHHHHHHHHHcCCCEEEEEeeCCCCCCCC-CcccchHHH Confidence 3567888876 89999999999999999888999999999999999999999994499999999998764 568999999 Q NP_000282.1 82 AVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVY 161 (417) Q Consensus 82 a~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Diy 161 (417) +++|+++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|++++++++.+..+.+.+++.+|++.||+++|+| T Consensus 83 a~~L~~~l~~~v~f~~~~~g~~~~~~i~~~~~g~illLENlRf~~~E~~~~~~a~~~~~~~~~~~~~~fa~~La~~~diy 162 (417) T 3OZ7_B 83 AETLKGLLGEEVLFLNDCVGKEVEDKINAAKENSVILLENLRFHIEEEGKGVDANGNKVKANKEDVEKFQNDLTKLADVF 162 (417) T ss_dssp HHHHHHHHTSCCEEESCSSSHHHHHHHHHSCTTEEEEECCGGGSHHHHSEEECTTSCEEECCHHHHHHHHHHHHTTCSEE T ss_pred HHHHHHHhCCEEEEecccCCHHHHHHHHHccCCCEEEEecccccchhccCCCCCCCCccccCHHhHHHHHHHHhhcCCEE Confidence 99999999877999999999888888899999999999999999977632111000000111112467999999999999 Q NP_000282.1 162 VNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMA 241 (417) Q Consensus 162 VNDAFg~aHR~~aS~~gi~l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a 241 (417) |||||+++||.|||+++++...++||++|++||++|.+++++|+||+++|+||+|++||+++|++|+++||.|+|||+|| T Consensus 163 VnDAF~~~HR~~ASv~gi~~~~~~aG~l~~kEi~~L~~~~~~p~rP~v~IlGG~Kv~dKi~~i~~Ll~~~D~IligG~~a 242 (417) T 3OZ7_B 163 INDAFGTAHRAHSSMVGVKLNVKASGFLMKKELEYFSKALENPQRPLLAILGGAKVSDKIQLIKNLLDKVDRMIIGGGMA 242 (417) T ss_dssp EEECGGGTTSCCHHHHCCCCSEEEECHHHHHHHHHHHHHHSSCCSSEEEEECSSCSGGGHHHHHHHHHHCSEEEECTTHH T ss_pred EecccccCCCCCCchHHHHhcHHhhCHHHHHHHHHHHHHHhCCCCCEEEEEcCCCHHHHHHHHHHHHHhCCEEEECcHHH Confidence 99999999999999999993228999999999999999999999999999999999999999999999999999999999 Q NP_000282.1 242 FTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESS 321 (417) Q Consensus 242 ~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 321 (417) |+||+|++++++|+|++|++..+.|++++++|+.++++|++|+|++|.+....++....+...+.+|++|+++||||+|+ T Consensus 243 ~~fl~a~~~~~vg~s~~e~~~~~~a~~il~~a~~~~~ki~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 322 (417) T 3OZ7_B 243 YTFKKVLNNMKIGTSLFDEAGSKIVGEIMEKAKAKNVQIFLPVDFKIADNFDNNANTKFVTDEEGIPDNWMGLDAGPKSI 322 (417) T ss_dssp HHHHHHHHCCCBTTCCCCTTTHHHHHHHHHHHHHTTCEEECCSEEEEESSSSTTSCEEEEETTTCBCTTCEEEEECHHHH T ss_pred HHHHHHHCCCcCCccccchhhHHHHHHHHHHHHHcCCEEEEeeeeeecccCCCCCcCceecCcCCCCCCcccccCCHHHH Confidence 99999984558999999998999999999998889999999999999987533221111222237888999999999999 Q NP_000282.1 322 KKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 401 (417) Q Consensus 322 ~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le 401 (417) +.|+++|++|||||||||||+||.++|++||+++++++++++++++++|+|||||+++++++|+.++++||||||||+|| T Consensus 323 ~~~~~~I~~aktI~wnGplG~~E~~~f~~GT~~i~~~l~~~~~~~a~~vvGGGdT~~~~~~~g~~~~~~~vSTgGGA~Le 402 (417) T 3OZ7_B 323 ENYKDVILTSKTVIWNGPQGVFEMPNFAKGSIECLNLVVEVTKKGAITIVGGGDTASLVEQQNKKNEISHVSTGGGASLE 402 (417) T ss_dssp HHHHHHHHTCSEEEEESCSBCTTSGGGCHHHHHHHHHHHHHHHHTCEEEECSHHHHHHHHHHTCGGGSSEECCCSHHHHH T ss_pred HHHHHHHHhCCEEEEeCCCccccCCCcChhHHHHHHHHHHHhcCCCEEEEeChHHHHHHHHcCCCCCcEEEEechHHHHH Confidence 99999999999999999999999888999999999999763224789999999999988888887789999999999999 Q NP_000282.1 402 LLEGKVLPGVDALSN 416 (417) Q Consensus 402 ~L~G~~LPgl~aL~~ 416 (417) ||+|++||||++|++ T Consensus 403 ~L~G~~LPgi~aL~~ 417 (417) T 3OZ7_B 403 LLEGKELPGVLALSN 417 (417) T ss_dssp HHTTCCCHHHHTSCC T ss_pred HHcCCCCChhHhhcC Confidence 999999999999974 No 16 >4DG5_A Phosphoglycerate kinase (E.C.2.7.2.3); Bi-lobal protein, Transferase, ATP Synthesis; 2.3A {Staphylococcus aureus} Probab=100.00 E-value=5.2e-109 Score=836.15 Aligned_cols=392 Identities=44% Similarity=0.770 Sum_probs=353.4 Template_Neff=6.300 Q NP_000282.1 5 NKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVE 84 (417) Q Consensus 5 ~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~~ 84 (417) .++++.+.|++|||||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++.+||+||+++ T Consensus 9 ~~~~~~~~dl~gK~vlvR~D~NVP~~~~~i~dd~RI~~~lpTI~~L~~~ga-kvvl~sHlGrP~g~~~~~~~Sl~pva~~ 87 (403) T 4DG5_A 9 AKKIVSDLDLKGKTVLVRADFNVPLKDGEITNDNRIVQALPTIQYIIEQGG-KIVLFSHLGKVKEESDKAKLTLRPVAED 87 (403) T ss_dssp CBCBGGGSCCTTCEEEEECCCCCCCSSSCCSCTHHHHHHHHHHHHHHHTTC-EEEEECCCSCCCSGGGSGGGCSHHHHHH T ss_pred ccccCCchhcCCCEEEEEeecccccCCCCcCCchHHHHHHHHHHHHHHCCC-EEEEEeccCccCCccchhhcchHHHHHH Confidence 467788889999999999999999998899999999999999999999999 5999999999987522457999999999 Q NP_000282.1 85 LKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVND 164 (417) Q Consensus 85 L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVND 164 (417) |+++|+.+|.|+++|+|+++++.++.+++|+|+||||+|||++|.+. +. +++.+|++.||+++|+|||| T Consensus 88 L~~~l~~~V~f~~d~~g~~~~~~i~~~~~g~illLENlRf~~~E~~~-e~----------~n~~~fa~~LA~l~DiyVND 156 (403) T 4DG5_A 88 LSKKLDKEVVFVPETRGEKLEAAIKDLKEGDVLLVENTRYEDLDGKK-ES----------KNDPELGKYWASLGDVFVND 156 (403) T ss_dssp HHHHHTSCCEEESCSSSHHHHHHHHTCCTTCEEEECCGGGGGTTTTT-TT----------TTCHHHHHHHHTTCSEEEEC T ss_pred HHHHcCCeEEecCCcCCHHHHHHHHhccCCCEEEEccccccCCCCCc-cc----------ccCHHHHHHHHhcchHhhhc Confidence 99999877999999999888888899999999999999999865211 10 11478999999999999999 Q NP_000282.1 165 AFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAF 242 (417) Q Consensus 165 AFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a~ 242 (417) |||++||.|||+++++ +| ++||++|++|+++|.+++++|+||+++|+||+|++||+++|++|++++|.|++||+||| T Consensus 157 AF~~~HR~hAS~vgi~~~lp-s~aG~ll~kEl~~L~k~~~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~IligG~lA~ 235 (403) T 4DG5_A 157 AFGTAHREHASNVGISTHLE-TAAGFLMDKEIKFIGGVVNDPHKPVVAILGGAKVSDKINVIKNLVNIADKIIIGGGMAY 235 (403) T ss_dssp CGGGTTSCCCCCCCHHTSSC-EEECHHHHHHCCCCCHHHHSCCSSEEEEECSSCHHHHHHHHHHHTTTCSEEEECSTTHH T ss_pred CHhHccCcCcchHHHHHHHH-HHhhHHHHHHHHHHHHHHhCCCCCEEEEEcCCcHHHHHHHHHHHHHHcCEEEEcchHHH Confidence 9999999999999999 67 89999999999999999999999999999999999999999999998899999999999 Q NP_000282.1 243 TFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSK 322 (417) Q Consensus 243 tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti~ 322 (417) +||+|+ |+++|+|++|++..+.|++++++ ++++|++|+|++|.+.+..++... ..+.+.+|++|+++||||+|++ T Consensus 236 tfL~a~-g~~vg~s~~e~~~~~~a~~ll~~---~~~ki~lP~D~~v~~~~~~~~~~~-~~~~~~i~~~~~~~DIGp~Ti~ 310 (403) T 4DG5_A 236 TFLKAQ-GKEIGISLLEEDKIDFAKDLLEK---HGDKIVLPVDTKVAKEFSNDAKIT-VVPSDSIPADQEGMDIGPNTVK 310 (403) T ss_dssp HHHHHT-TCCCTTSCCCGGGHHHHHHHHHH---STTTEECCSEEEEESSSSTTSCCE-EEEGGGCCTTCEEEEECHHHHH T ss_pred HHHHHc-CCeeeeeecchhhHHHHHHHHHH---ccCceEeeceeeeecccCCCCceE-EecCCCCCCCcccccCCHHHHH Confidence 999998 88999999999888999998873 588999999999998754322211 1122578889999999999999 Q NP_000282.1 323 KYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLEL 402 (417) Q Consensus 323 ~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le~ 402 (417) .|.+.|++|||||||||||+||.++|++||+++++++++++ ++++|+|||||+++++++|+.++++||||||||+||| T Consensus 311 ~~~~~I~~aktI~wnGP~G~~E~e~f~~GT~~i~~aia~~~--~a~~ivGGGdT~~~~~~~g~~~~~~~vStGGGA~Le~ 388 (403) T 4DG5_A 311 LFADELEGAHTVVWNGPMGVFEFSNFAQGTIGVCKAIANLK--DAITIIGGGDSAAAAISLGFENDFTHISTGGGASLEY 388 (403) T ss_dssp HHHHTTTTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHCS--SSEEEECSHHHHHHHHHTTCGGGSSEECSCHHHHHHH T ss_pred HHHHHHhcCCEEEEeCCCccccCccccchHHHHHHHHHhcC--CCEEEEeCchHHHHHHHcCCCCCceEEEechHHHHHH Confidence 99999999999999999999988889999999999997632 7899999999999998889888899999999999999 Q NP_000282.1 403 LEGKVLPGVDALSN 416 (417) Q Consensus 403 L~G~~LPgl~aL~~ 416 (417) |+|+.||||++|++ T Consensus 389 L~Gk~LPgl~aL~~ 402 (403) T 4DG5_A 389 LEGKELPGIKAINN 402 (403) T ss_dssp HTTCCCHHHHTSCB T ss_pred HcCCCCCchHHhhc Confidence 99999999999975 No 17 >6HXE_A Phosphoglycerate kinase (E.C.2.7.2.3); Complex, 3-phosphoglycerate, hinge binding, TRANSFERASE; HET: 3PG; 2.1A {Pseudomonas sp. 'TAC II 18'} Probab=100.00 E-value=4.3e-108 Score=826.14 Aligned_cols=381 Identities=39% Similarity=0.690 Sum_probs=341.5 Template_Neff=6.400 Q NP_000282.1 4 SNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAV 83 (417) Q Consensus 4 ~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~ 83 (417) |.++++++.|++||+||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++++||+||++ T Consensus 1 ~~~~~l~~~~l~gK~vl~R~D~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~ga-~vil~sHlGrP~g~~~~~~~Sl~~va~ 79 (387) T 6HXE_A 1 MTVLKMTDLDLQGKRVLIREDLNVPVKDGVVTSDARILASLPTIKLALEKGA-AVMVCSHLGRPTEGEFSAENSLKPVAD 79 (387) T ss_dssp -CCCBGGGSCCTTCEEEEECCCCCCEETTEECCCHHHHHHHHHHHHHHHTTC-EEEEECCCSCCCTTSCCGGGCSHHHHH T ss_pred CCccccchhhcCCCEEEEEeecCccccCCccCCcHHHHhHHHHHHHHHHcCC-cEEEEeecCCCCCCCCChhhcHHHHHH Confidence 3477788888999999999999999998899999999999999999999999 599999999998652245899999999 Q NP_000282.1 84 ELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVN 163 (417) Q Consensus 84 ~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVN 163 (417) +|+++|+.+|.|++++++. ..+++|+|+||||+|||++|+++ +.+|++.||+++|+||| T Consensus 80 ~L~~~l~~~v~f~~d~~~~------~~~~~g~i~lLENlRF~~~E~~n---------------~~~fa~~La~l~DiyVn 138 (387) T 6HXE_A 80 YLSKALGREVPLVSDYLNG------VDVKAGDIVLFENVRFNKGEKKN---------------ADELAKQYAALCDVFVM 138 (387) T ss_dssp HHHHHHTSCCCEESCCTTC------CCCCTTCEEEECCGGGSTTTTTT---------------CHHHHHHHHHTCSEEEE T ss_pred HHHHHhCCCCCccccccCC------ccCCCCcEEEEeCccCCCccccC---------------HHHHHHHHHHcccHhhc Confidence 9999998779999865542 27889999999999999876532 36799999999999999 Q NP_000282.1 164 DAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMA 241 (417) Q Consensus 164 DAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a 241 (417) |||+++||.|||+++++ +|+++||++|++||++|++++++|+||+++|+||+|++||+++|++|++++|.|++||+|| T Consensus 139 DAF~~~HR~haS~vgi~~~l~~s~aG~l~~kEl~~L~~~l~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~iligG~~a 218 (387) T 6HXE_A 139 DAFGTAHRAEGSTHGVAKFAKVAAAGPLLAAELDALGKALGAPAKPMAAIVAGSKVSTKLDVLNSLSQICDLLIVGGGIA 218 (387) T ss_dssp CCGGGTTCCCCCCCCHHHHSSEEEECHHHHHHHHHHHHHHTSCCSSEEEEEEESCTGGGHHHHHHHHTTCSEEEEEHHHH T ss_pred ccHhhcccccCchhhHhhccchhhHHHHHHHHHHHHHHHHcCCCCCeEEEEcCCCHHHHHHHHHHHHHHCCEEEEeChHH Confidence 99999999999999998 6668999999999999999999999999999999999999999999999889999999999 Q NP_000282.1 242 FTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESS 321 (417) Q Consensus 242 ~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 321 (417) |+||+|+ |+++|+|++|++..+.|+++++ +++|++|+|++|.+.+..++... ......+|++|+++||||+|+ T Consensus 219 ~tfL~a~-g~~vg~S~~e~~~~~~a~~il~-----~~ki~lP~D~vv~~~~~~~~~~~-~~~~~~ip~~~~~~DIGp~Ti 291 (387) T 6HXE_A 219 DTFLAAA-GHPVGKSLYEPDLLDTARAIAA-----KVNVPLPTDVVVAKEFAESAEAT-VKLIADVAADDMILDIGPQTA 291 (387) T ss_dssp HHHHHHT-TCCCCSSCCCGGGHHHHHHHHH-----HSBCCCCSEEEEESCSSTTCCCE-EEEGGGCCTTCEEEEECHHHH T ss_pred HHHHHHc-CCCCCccccChhHHHHHHHHHH-----cCcccccccEEEchhhhccccce-EEehhhcCCCceeecCCHHHH Confidence 9999998 8899999999888888888864 58999999999998754322110 111237888999999999999 Q NP_000282.1 322 KKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 401 (417) Q Consensus 322 ~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le 401 (417) +.|+++|++|||||||||||+||+++|++||+++++++++. ++++|+|||||+++++++|+.++++||||||||+|| T Consensus 292 ~~~~~~I~~aktI~wNGP~G~~E~~~f~~GT~~i~~al~~~---~a~~ivGGGdT~~~~~~~g~~~~~s~vSTGGGA~Le 368 (387) T 6HXE_A 292 EHFAQLLKTSKTILWNGPVGVFEFDQFGNGTKVLAKAIADS---AAFSIAGGGDTLAAIDKYGVADQISQISTGGGAFLE 368 (387) T ss_dssp HHHHHHHHHCSEEEEECCSSCTTSGGGCHHHHHHHHHHHHC---SSEEEEESHHHHHHHHHHTCGGGSSEEECCHHHHHH T ss_pred HHHHHHHHcCCeEEEcCCCCccccCccCcHHHHHHHHHHhc---CCeEEEcCHHHHHHHHHhCCCccceEEEcchhHHHH Confidence 99999999999999999999999888999999999999762 689999999999989988988889999999999999 Q NP_000282.1 402 LLEGKVLPGVDALSN 416 (417) Q Consensus 402 ~L~G~~LPgl~aL~~ 416 (417) ||+|+.||||++|++ T Consensus 369 ~L~G~~LPgl~aL~~ 383 (387) T 6HXE_A 369 FVEGKVLPAVEVLES 383 (387) T ss_dssp HHTTCCCHHHHHHHH T ss_pred HHcCCCCchHHHHHH Confidence 999999999999985 No 18 >4NG4_B Phosphoglycerate kinase (E.C.2.7.2.3); phosphoglycerate kinase, TRANSFERASE; HET: ADP; 2.78A {Coxiella burnetii} Probab=100.00 E-value=4.7e-108 Score=829.99 Aligned_cols=389 Identities=41% Similarity=0.687 Sum_probs=351.1 Template_Neff=6.400 Q NP_000282.1 1 MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEP 80 (417) Q Consensus 1 ~~~~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~ 80 (417) |+...++++++.|++||+||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++.+||+| T Consensus 9 ~~~~~~~~~~~~~l~gk~vlvR~D~NVp~~~~~i~dd~Ri~~~lpTI~~Ll~~ga-kvvl~sHlGrP~~~~~~~~~Sl~~ 87 (404) T 4NG4_B 9 MKALPFLSMSNLNLHNKRVMIREDLNVPMKNGKITNDERIVRALPTIQKAIEQKA-RVMILSHLGRPEEGKFEKEFSLAP 87 (404) T ss_dssp ----CCCBGGGSCCTTCEEEEEECCCCCEETTEESCCHHHHHHHHHHHHHHHTTC-EEEEEECCSCCCTTCCCGGGCSHH T ss_pred ccccccccccccccCCCEEEEEeecCccccCCccCCcHHHHHHHHHHHHHHHCCC-eEEEEeeccCcCCCCCcccccHHH Confidence 5666778887788999999999999999988899999999999999999999999 599999999998753246899999 Q NP_000282.1 81 VAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDV 160 (417) Q Consensus 81 va~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Di 160 (417) |+++|+++|+.+|.|+++|++. ..+++|+|+||||+|||++|+.+ +++|+++||+++|+ T Consensus 88 v~~~L~~~l~~~v~fv~d~~~~------~~~~~g~ilLLENlRf~~~E~~~---------------~~~fa~~La~l~Di 146 (404) T 4NG4_B 88 VARLLSKKLNQKVPLINDWLKG------VAVEPGQAILCENVRFNKGENEN---------------NTELAKRMAELCDI 146 (404) T ss_dssp HHHHHHHHTC-CCCEESSGGGC------CCCCTTCEEEECCGGGSTTTTTT---------------CHHHHHHHHHTCSE T ss_pred HHHHHHHHhCCCCCcccccccc------ccCCCCCEEEEeccccCCccccc---------------cHHHHHHHHhcccH Confidence 9999999998779999999873 37889999999999999976532 36799999999999 Q NP_000282.1 161 YVNDAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGG 238 (417) Q Consensus 161 yVNDAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG 238 (417) ||||||+++||.|||+++++ +|+++||++|++|+++|++++++|+||+++|+||+|++||+++|++|++++|.|+||| T Consensus 147 yVnDAF~~~HR~~aS~~gi~~~l~~~~aG~l~~kEl~~l~~~~~~p~~P~v~IlGG~Kv~dKi~li~~Ll~~~D~iligG 226 (404) T 4NG4_B 147 FVMDAFATAHRAQASTAGVAAYAKLACAGPLLISEVEALSRALENPQKPLVAVVGGSKVSTKIHLLENLLDKVDQLIVGG 226 (404) T ss_dssp EEECCGGGTTSCCCCCCCHHHHCSEEEECHHHHHHHHHHHHHHHSCCSSEEEEEEESCGGGTHHHHHHHHTTCSEEEEEE T ss_pred hhhcCHhHcccccccccchhhccchhhhhHHHHHHHHHHHHHHhCCCCCEEEEECCCCHHHHHHHHHHHHHhcCeEEEcC Confidence 99999999999999999998 6658999999999999999999999999999999999999999999999999999999 Q NP_000282.1 239 GMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGP 318 (417) Q Consensus 239 ~~a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp 318 (417) +||++||+|+ |+++|+|++|++..+.|++++++|++++++|++|+|++|.+.+..++.. .......+|++|+++|||| T Consensus 227 ~~a~tFL~a~-g~~ig~S~~e~~~~~~a~~ll~~a~~~~~kI~lP~D~vv~~~~~~~~~~-~~~~~~~i~~~~~~lDIGp 304 (404) T 4NG4_B 227 GIANTFLKAQ-GYSIGKSLCENEWLDAAQQFWEKAAEKNVSLPLPVDVIVADELSEDAKA-TVKNIDAVTSNESIFDVGP 304 (404) T ss_dssp HHHHHHHHHT-TCCCTTCCCCGGGHHHHHHHHHHHHHHTCBCCCCSEEEEESSCSTTSCC-EEEEGGGCCTTCEEEEECH T ss_pred HHHHHHHHHc-CCCcccccccchHHHHHHHHHHHHHHCCCCcCceeEEEEcccCCccccc-EeecccccCCCcccccCCH Confidence 9999999998 8999999999999999999999999999999999999999875433221 1112247888999999999 Q NP_000282.1 319 ESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGA 398 (417) Q Consensus 319 ~Ti~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA 398 (417) +|++.|+++|++|||||||||||+||+++|++||+++++++++. ++++|+|||||+++++++++.++++|||||||| T Consensus 305 ~Ti~~~~~~I~~aktI~wnGp~G~~E~~~f~~GT~~i~~~l~~~---~a~sivGGGDT~~~~~~~~~~~~~~~vStgGgA 381 (404) T 4NG4_B 305 NTSATYAKLMAQAGTIVWNGPIGVFEIEAFSQGTRALAQAVAKS---TAYSIVGGGDTLAALDKFNLTDQMSYVSTAGGA 381 (404) T ss_dssp HHHHHHHHHHHHCSEEEEESCSSCTTSSTTCHHHHHHHHHHHHS---CSEEEECCHHHHHHHHHTTCGGGSSEECCCTHH T ss_pred HHHHHHHHHHHhCCEEEEeCCCCcccchhHcHHHHHHHHHHHhC---CCCEEEccHHHHHHHHHCCCCcCceEEecccHH Confidence 99999999999999999999999999888999999999999763 689999999999999989988889999999999 Q NP_000282.1 399 SLELLEGKVLPGVDALSN 416 (417) Q Consensus 399 ~Le~L~G~~LPgl~aL~~ 416 (417) +||||+|++||||++|++ T Consensus 382 ~Le~L~G~~LPgl~aL~~ 399 (404) T 4NG4_B 382 FLEFLEGKILPAIKILTQ 399 (404) T ss_dssp HHHHHHTCCCHHHHHHHH T ss_pred HHHHHcCCCChHHHHHHH Confidence 999999999999999986 No 19 >4NG4_C Phosphoglycerate kinase (E.C.2.7.2.3); phosphoglycerate kinase, TRANSFERASE; HET: ADP; 2.78A {Coxiella burnetii} Probab=100.00 E-value=4.7e-108 Score=829.99 Aligned_cols=389 Identities=41% Similarity=0.687 Sum_probs=348.3 Template_Neff=6.400 Q NP_000282.1 1 MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEP 80 (417) Q Consensus 1 ~~~~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~ 80 (417) |+...++++++.|++||+||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++.+||+| T Consensus 9 ~~~~~~~~~~~~~l~gk~vlvR~D~NVp~~~~~i~dd~Ri~~~lpTI~~Ll~~ga-kvvl~sHlGrP~~~~~~~~~Sl~~ 87 (404) T 4NG4_C 9 MKALPFLSMSNLNLHNKRVMIREDLNVPMKNGKITNDERIVRALPTIQKAIEQKA-RVMILSHLGRPEEGKFEKEFSLAP 87 (404) T ss_dssp ----CCCBGGGSCCTTCEEEEEECCCCCEETTEESCCHHHHHHHHHHHHHHHTTC-EEEEEECCSCCCTTCCCGGGCSHH T ss_pred ccccccccccccccCCCEEEEEeecCccccCCccCCcHHHHHHHHHHHHHHHCCC-eEEEEeeccCcCCCCCcccccHHH Confidence 5666778887788999999999999999988899999999999999999999999 599999999998753246899999 Q NP_000282.1 81 VAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDV 160 (417) Q Consensus 81 va~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Di 160 (417) |+++|+++|+.+|.|+++|++. ..+++|+|+||||+|||++|+.+ +++|+++||+++|+ T Consensus 88 v~~~L~~~l~~~v~fv~d~~~~------~~~~~g~ilLLENlRf~~~E~~~---------------~~~fa~~La~l~Di 146 (404) T 4NG4_C 88 VARLLSKKLNQKVPLINDWLKG------VAVEPGQAILCENVRFNKGENEN---------------NTELAKRMAELCDI 146 (404) T ss_dssp HHHHHHHHCC--CCEESSGGGC------CCCCTTCEEEECCGGGSTTTTTT---------------CHHHHHHHHHTCSE T ss_pred HHHHHHHHhCCCCCcccccccc------ccCCCCCEEEEeccccCCccccc---------------cHHHHHHHHhcccH Confidence 9999999998779999999873 37889999999999999976532 36799999999999 Q NP_000282.1 161 YVNDAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGG 238 (417) Q Consensus 161 yVNDAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG 238 (417) ||||||+++||.|||+++++ +|+++||++|++|+++|++++++|+||+++|+||+|++||+++|++|++++|.|+||| T Consensus 147 yVnDAF~~~HR~~aS~~gi~~~l~~~~aG~l~~kEl~~l~~~~~~p~~P~v~IlGG~Kv~dKi~li~~Ll~~~D~iligG 226 (404) T 4NG4_C 147 FVMDAFATAHRAQASTAGVAAYAKLACAGPLLISEVEALSRALENPQKPLVAVVGGSKVSTKIHLLENLLDKVDQLIVGG 226 (404) T ss_dssp EEECCGGGTTSCCCCCCCHHHHCSEEEECHHHHHHHHHHHHHHHSCCSSEEEEEEESCGGGTHHHHHHHHTTCSEEEEEE T ss_pred hhhcCHhHcccccccccchhhccchhhhhHHHHHHHHHHHHHHhCCCCCEEEEECCCCHHHHHHHHHHHHHhcCeEEEcC Confidence 99999999999999999998 6658999999999999999999999999999999999999999999999999999999 Q NP_000282.1 239 GMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGP 318 (417) Q Consensus 239 ~~a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp 318 (417) +||++||+|+ |+++|+|++|++..+.|++++++|++++++|++|+|++|.+.+..++.. .......+|++|+++|||| T Consensus 227 ~~a~tFL~a~-g~~ig~S~~e~~~~~~a~~ll~~a~~~~~kI~lP~D~vv~~~~~~~~~~-~~~~~~~i~~~~~~lDIGp 304 (404) T 4NG4_C 227 GIANTFLKAQ-GYSIGKSLCENEWLDAAQQFWEKAAEKNVSLPLPVDVIVADELSEDAKA-TVKNIDAVTSNESIFDVGP 304 (404) T ss_dssp HHHHHHHHHT-TCCCTTCCCCGGGHHHHHHHHHHHHHHTCBCCCCSEEEEESSCSTTSCC-EEEEGGGCCTTCEEEEECH T ss_pred HHHHHHHHHc-CCCcccccccchHHHHHHHHHHHHHHCCCCcCceeEEEEcccCCccccc-EeecccccCCCcccccCCH Confidence 9999999998 8999999999999999999999999999999999999999875433221 1112247888999999999 Q NP_000282.1 319 ESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGA 398 (417) Q Consensus 319 ~Ti~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA 398 (417) +|++.|+++|++|||||||||||+||+++|++||+++++++++. ++++|+|||||+++++++++.++++|||||||| T Consensus 305 ~Ti~~~~~~I~~aktI~wnGp~G~~E~~~f~~GT~~i~~~l~~~---~a~sivGGGDT~~~~~~~~~~~~~~~vStgGgA 381 (404) T 4NG4_C 305 NTSATYAKLMAQAGTIVWNGPIGVFEIEAFSQGTRALAQAVAKS---TAYSIVGGGDTLAALDKFNLTDQMSYVSTAGGA 381 (404) T ss_dssp HHHHHHHHHHHHCSEEEEESCSSCTTSSGGGHHHHHHHHHHHHS---CSEEEECCHHHHHHHHHTTCGGGSSEECCCTHH T ss_pred HHHHHHHHHHHhCCEEEEeCCCCcccchhHcHHHHHHHHHHHhC---CCCEEEccHHHHHHHHHCCCCcCceEEecccHH Confidence 99999999999999999999999999888999999999999763 689999999999999989988889999999999 Q NP_000282.1 399 SLELLEGKVLPGVDALSN 416 (417) Q Consensus 399 ~Le~L~G~~LPgl~aL~~ 416 (417) +||||+|++||||++|++ T Consensus 382 ~Le~L~G~~LPgl~aL~~ 399 (404) T 4NG4_C 382 FLEFLEGKILPAIKILTQ 399 (404) T ss_dssp HHHHHHC--CHHHHHHHH T ss_pred HHHHHcCCCChHHHHHHH Confidence 999999999999999986 No 20 >6I06_A Phosphoglycerate kinase (E.C.2.7.2.3); hinge binding, TRANSFERASE, kinase, glycolysis; 2.0A {Pseudomonas} Probab=100.00 E-value=1e-107 Score=823.37 Aligned_cols=381 Identities=39% Similarity=0.687 Sum_probs=326.8 Template_Neff=6.400 Q NP_000282.1 4 SNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAV 83 (417) Q Consensus 4 ~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~ 83 (417) |.++++++.|++|||||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++.+||+||++ T Consensus 1 ~~~~~l~~~~l~gK~vlvR~D~NVPl~~~~i~d~~RI~~~lpTI~~L~~~ga-kvil~sHlGrP~g~~~~~~~Sl~~va~ 79 (387) T 6I06_A 1 MTVLKMTDLDLQGKRVLIREDLNVPVKDGVVTSDARILASLPTIKLALEKGA-AVMVCSHLGRPTEGEFSAENSLKPVAD 79 (387) T ss_dssp CCBGG--GSCCTTCEEEEECCCCCCBSSSCBSCCHHHHHHHHHHHHHHHTTC-EEEEECCCSCCCTTSCCGGGCSHHHHH T ss_pred CCCccCChHHcCCCEEEEEeecCcccCCCCCCCcHHHHHHHHHHHHHHHCCC-cEEEEeecCCCCCCCCCcccchHHHHH Confidence 3467777788999999999999999998899999999999999999999999 599999999998652235799999999 Q NP_000282.1 84 ELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVN 163 (417) Q Consensus 84 ~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVN 163 (417) +|+++|+.+|.|+++++.. ..+++|+|+||||+|||++|+++ +.+|++.||+++|+||| T Consensus 80 ~L~~~l~~~v~f~~~~~~~------~~l~~g~illLENlRF~~~E~~n---------------~~~fa~~La~l~DiyVn 138 (387) T 6I06_A 80 YLSKALGREVPLVSDYLNG------VDVKAGDIVLFENVRFNKGEKKN---------------ADELAKQYAALCDVFVM 138 (387) T ss_dssp HHHHHHTSCCCEESCCTTC------CCCCTTCEEEECCGGGSTTTTTT---------------CHHHHHHHHHTCSEEEE T ss_pred HHHHHHCCCceecCCCCCC------ccCCCCcEEEEeCcccCCCcccC---------------CHHHHHHHHhhccHhhc Confidence 9999998778999855442 26889999999999999876532 36799999999999999 Q NP_000282.1 164 DAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMA 241 (417) Q Consensus 164 DAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a 241 (417) |||+++||.|||+++++ +|+++||++|++|+++|++++++|+||+++|+||+|++||+++|++|++++|.|++||+|| T Consensus 139 DAF~~~HR~~aS~vgi~~~lp~s~aG~l~~kEl~~L~~~~~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~iligG~~a 218 (387) T 6I06_A 139 DAFGTAHRAEGSTHGVAKFAKVAAAGPLLAAELDALGKALGAPAKPMAAIVAGSKVSTKLDVLNSLSQICDLLIVGGGIA 218 (387) T ss_dssp CCGGGTTSCCCCCCCHHHHSSEEEECHHHHHHHHHHHHHHSSCCSSEEEEEEESCTGGG--HTCSEE------EEEHHHH T ss_pred ccHhhcccccccccccccCCCchhhhHHHHHHHHHHHHHHhCCCCCEEEEEcCCCHHHHHHHHHHHHHcCCEEEEcChHH Confidence 99999999999999998 6668999999999999999999999999999999999999999999999889999999999 Q NP_000282.1 242 FTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESS 321 (417) Q Consensus 242 ~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 321 (417) |+||+|+ |+++|+|++|++..+.|+++++ +++|++|+|++|.+.+..+.... .....++|++|+++||||+|+ T Consensus 219 ~tfL~a~-g~~vg~S~~e~~~~~~a~~il~-----~~ki~lP~D~vv~~~~~~~~~~~-~~~~~~ip~~~~~~DIGp~Ti 291 (387) T 6I06_A 219 DTFLAAA-GHPVGKSLYEPDLLDTARAIAA-----KVNVPLPTDVVVAKEFAESAEAT-VKLIADVAADDMILDIGPQTA 291 (387) T ss_dssp HHHHHHT-TCCCBSCCCCGGGHHHHHHHHH-----HSBCCCCSEEEEESCSSTTCCCE-ECCTTC-----EEEEECHHHH T ss_pred HHHHHHc-CCcccccccchhHHHHHHHHHh-----cCeEEcccCEEecccCCCCCCcc-eeccccCCCCceeecCCHHHH Confidence 9999998 8889999999888888888764 68999999999998653321110 111237888999999999999 Q NP_000282.1 322 KKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 401 (417) Q Consensus 322 ~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le 401 (417) +.|+++|++|||||||||||+||+++|++||+++++++++. ++++|+|||||+++++++|+.++++||||||||+|| T Consensus 292 ~~~~~~I~~aktI~wnGp~G~~E~~~f~~GT~~i~~ai~~~---~a~~ivGGGdT~~~~~~~g~~~~~~~vStgGGA~L~ 368 (387) T 6I06_A 292 EHFAQLLKTSKTILWNGPVGVFEFDQFGNGTKVLAKAIADS---AAFSIAGGGDTLAAIDKYGVADQISYISTGGGAFLE 368 (387) T ss_dssp HHHHHHHHTCSEEEEECCSBCTTSGGGCHHHHHHHHHHHHS---CSEEEEESHHHHHHHHHHTCGGGSSEEECCTHHHHH T ss_pred HHHHHHHHhCCEEEEeCCCChhcCCccchHHHHHHHHHHhC---CCcEEEcCHHHHHHHHHcCCccCcEEEEechHHHHH Confidence 99999999999999999999999888999999999999762 689999999999999988988889999999999999 Q NP_000282.1 402 LLEGKVLPGVDALSN 416 (417) Q Consensus 402 ~L~G~~LPgl~aL~~ 416 (417) ||+|++||||++|++ T Consensus 369 ~L~G~~LPgl~aL~~ 383 (387) T 6I06_A 369 FVEGKVLPAVEVLES 383 (387) T ss_dssp HHTTCCCHHHHHHHH T ss_pred HHcCCCCchHHHHhH Confidence 999999999999975 No 21 >2CUN_A Phosphoglycerate kinase (E.C.2.7.2.3); Phosphoglycerate kinase, Structural Genomics, TANPAKU; HET: 3PG, MPD, GOL; 2.1A {Pyrococcus horikoshii} Probab=100.00 E-value=3.4e-105 Score=811.02 Aligned_cols=387 Identities=33% Similarity=0.531 Sum_probs=341.8 Template_Neff=6.500 Q NP_000282.1 8 TLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKS 87 (417) Q Consensus 8 ~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~~L~~ 87 (417) +++|.|++||+||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++. .+|++||+++|++ T Consensus 3 ~~~~~~l~gK~vlvR~D~Nvpl~~~~i~d~~Ri~~~lpTI~~Ll~~ga-kvvl~sH~GrP~~~~---~~sl~~v~~~L~~ 78 (410) T 2CUN_A 3 RLEDFNFHNKTVFLRVDLNSPMKDGKIISDARFKAVLPTIRYLIESGA-KVVIGTHQGKPYSED---YTTTEEHARVLSE 78 (410) T ss_dssp BGGGSCCTTCEEEEECCCCCCEETTEECCCHHHHHTHHHHHHHHHTTC-EEEEECCCSCTTCTT---CCCSHHHHHHHHH T ss_pred ccccccCCCCEEEEEeeCCCcccCCCCCCcHHHHHHHHHHHHHHHCCC-cEEEEeccCCCCCCC---CCCHHHHHHHHHH Confidence 456678999999999999999998899999999999999999999999 599999999998753 6899999999999 Q NP_000282.1 88 LLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFG 167 (417) Q Consensus 88 ~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVNDAFg 167 (417) +|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|++++++ +++++..|++.||+++|+||||||+ T Consensus 79 ~l~~~v~f~~~~~g~~~~~~i~~~~~g~illLENlRF~~~E~~~~~~--------~~~~~~~fa~~La~l~DiyVnDAF~ 150 (410) T 2CUN_A 79 LLDQHVEYIEDIFGRYAREKIKELKSGEVAILENLRFSAEEVKNKPI--------EECEKTFLVKKLSKVIDYVVNDAFA 150 (410) T ss_dssp HHTSCEEECSCSSSHHHHHHHHTCCTTCEEECSCGGGBTTTTSCCCH--------HHHTTSHHHHHHHTTCSEEEECCGG T ss_pred HHcCcEEehhhccChhHHHHHHHccCCCEEEEeccccchhHhcCCCh--------hHhHHHHHHHHHhccCCEEEecccc Confidence 99877999999999888888899999999999999999977643110 0112356999999999999999999 Q NP_000282.1 168 TAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLD--KVNEMIIGGGMAFT 243 (417) Q Consensus 168 ~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~--~~D~iligG~~a~t 243 (417) ++||.|||+++++ +| ++||++|++||++|++++++|+||+++|+||+|++||+++|++|++ +||.|++||+||++ T Consensus 151 ~~HR~~aS~vgi~~~lp-s~aG~l~~kEl~~L~~~~~~p~rP~v~IlGG~KvsdKi~li~~Ll~~~~vD~IligG~~a~~ 229 (410) T 2CUN_A 151 TAHRSQPSLVGFARIKP-MIMGFLMEKEIEALMRAYYSKDSPKIYVLGGAKVEDSLKVVENVLRRERADLVLTGGLVANV 229 (410) T ss_dssp GTTCCCHHHHTTTTTSC-EEECHHHHHHHHHHHHHHTCCCSCEEEEECSSCHHHHHHHHHHHHHTTSCSEEEECHHHHHH T ss_pred cccCCCcchhhHHhhch-HHhcHHHHHHHHHHHHHHhCCCCCcEEEECCCCHHHHHHHHHHHHHHHhCCEEEEchhHHHH Confidence 9999999999998 66 8999999999999999999999999999999999999999999996 78999999999999 Q NP_000282.1 244 FLKVLNNMEIGTSLFDEE-------GAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDC 316 (417) Q Consensus 244 fl~a~~g~~ig~s~~e~~-------~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DI 316 (417) ||+|+ |+++|+|++|++ ..+.|+++++. ++++|++|+||+|.++... ...........+|++|+++|| T Consensus 230 fL~a~-g~~ig~s~~e~~~~~~~~~~~~~a~~il~~---~~~~I~lPvD~~v~~~~~~-~~~~~~~~~~~ip~~~~~~DI 304 (410) T 2CUN_A 230 FTLAK-GFDLGRKNVEFMKKKGLLDYVKHAEEILDE---FYPYIRTPVDFAVDYKGER-VEIDLLSENRGLLHQYQIMDI 304 (410) T ss_dssp HHHHH-TCCCCHHHHHHHHTTTGGGGHHHHHHHHHH---HGGGEECCSEEEEEETTEE-EEEESSSGGGGGGGTSCEEEE T ss_pred HHHHc-CCCCCcchHHHhHhhCHHHHHHHHHHHHHH---HCCccccceeEEecCCCCc-ceeeeeccccCCCCCceeecC Confidence 99998 899999987763 34555555542 6889999999999886432 111011122478899999999 Q NP_000282.1 317 GPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGG 396 (417) Q Consensus 317 Gp~Ti~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgG 396 (417) ||+|++.|+++|++|||||||||||+||+++|++||++++++++++ ++++|+|||||+++++++|+. +++|||||| T Consensus 305 Gp~Ti~~~~~~I~~aktI~wnGP~G~~E~e~f~~GT~~i~~ai~~~---~a~~vvGGGdT~~~~~~~g~~-~~s~vStgG 380 (410) T 2CUN_A 305 GKRTAEKYREILMKARIIVANGPMGVFEREEFAIGTVEVFKAIADS---PAFSVLGGGHSIASIQKYGIT-GITHISTGG 380 (410) T ss_dssp CHHHHHHHHHHHHTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHS---SSEEEEECGGGGGGGGGSCCC-CCSEECSCS T ss_pred CHHHHHHHHHHHhhCCEEEEeCCCCcccchhhchhHHHHHHHHHcC---CCEEEEecHHHHHHHHHhCCC-CcEEEEecc Confidence 9999999999999999999999999999888999999999999763 689999999999999888875 799999999 Q NP_000282.1 397 GASLELLEGKVLPGVDALSN 416 (417) Q Consensus 397 gA~Le~L~G~~LPgl~aL~~ 416 (417) ||+||||+|+.||||++|++ T Consensus 381 gA~Le~L~G~~LPgl~aL~~ 400 (410) T 2CUN_A 381 GAMLSFFAGEELPVLRALQI 400 (410) T ss_dssp HHHHHHHTTCCCHHHHHHHH T ss_pred hHHHHHHcCCCChHHHHHHH Confidence 99999999999999999975 No 22 >1FW8_A PHOSPHOGLYCERATE KINASE (E.C.2.7.2.3); phosphotransferase, kinase, phosphoglycerate kinase, glycolysis; HET: GOL; 2.3A {Saccharomyces cerevisiae} SCOP: c.86.1.1 Probab=100.00 E-value=8.8e-90 Score=698.26 Aligned_cols=342 Identities=68% Similarity=1.065 Sum_probs=299.2 Template_Neff=6.400 Q NP_000282.1 74 DKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRAS 153 (417) Q Consensus 74 ~~~Sl~~va~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~ 153 (417) +.+||+||+++|+++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|+++.++ ++.+.+++++++.+|++. T Consensus 2 ~~~Sl~pva~~L~~ll~~~V~f~~d~~g~~~~~~i~~~~~g~IllLENlRF~~~E~~~~~~-n~~~~~~~~~~~~~fa~~ 80 (416) T 1FW8_A 2 SKYSLAPVAKELQSLLGKDVTFLNDCVGPEVEAAVKASAPGSVILLENLRYHIEEEGSRKV-DGQKVKASKEDVQKFRHE 80 (416) T ss_dssp CTTCSHHHHHHHHHHHTSCEEECSCSSSHHHHHHHHTSCTTEEEECCCGGGSHHHHSEEEE-TTEEEECCHHHHHHHHHH T ss_pred CCccHHHHHHHHHHHHCCceeeccCCCCHHHHHHHHhcCCCCEEEEecceecccccccccc-CCcccccCHHHHHHHHHH Confidence 3689999999999999877999999999888888899999999999999999977632100 000001112234789999 Q NP_000282.1 154 LSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNE 233 (417) Q Consensus 154 LA~l~DiyVNDAFg~aHR~~aS~~gi~l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~ 233 (417) ||+++|+|||||||++||.|||++++++|+++||++|++||++|++++++|+||+++|+||+|++||+++|++|+++||. T Consensus 81 La~l~diyVnDAFg~~HR~~aS~vgi~lp~s~aG~ll~kEi~~L~kil~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~ 160 (416) T 1FW8_A 81 LSSLADVYINDAFGTAHRAHSSMVGFDLPQRAAGFLLEKELKYFGKALENPTRPFLAILGGAKVADKIQLIDNLLDKVDS 160 (416) T ss_dssp HHTTCSEEEECCGGGTTSCCHHHHCCCCSCEEECHHHHHHHHHHHHHHHSCCSSEEEEEECSCSTTTHHHHHHHHTTCSE T ss_pred HHhhCCeEeecccccCCccccCcccCCCchhhhcHHHHHHHHHHHHHhhCCCCCEEEEEcCCCHHHHHHHHHHHHHhcCE Confidence 99999999999999999999999999976589999999999999999999999999999999999999999999999999 Q NP_000282.1 234 MIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMG 313 (417) Q Consensus 234 iligG~~a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~ 313 (417) |++||+|||+||+|++++++|+|++|++..+.|++++++|+.++++|+||+|++|.+.+..+.....+...+.+|++|++ T Consensus 161 IligG~~a~tfL~a~~~~~iG~S~~e~~~~~~a~~il~~a~~~~~ki~LP~D~vv~~~~~~~~~~~~~~~~~~i~~~~~i 240 (416) T 1FW8_A 161 IIIGGGMAFTFKKVLENTEIGDSIFDKAGAEIVPKLMEKAKAKGVEVVLPVDFIIADAFSADANTKTVTDKEGIPAGWQG 240 (416) T ss_dssp EEEEGGGHHHHHHHHSCCCCCSCCCCHHHHHHHHHHHHHHHHHTCEEECCSEEEEESSSSTTCCEEEEETTTCCCTTCEE T ss_pred EEeCchHHHHHHHHhCCCccCccccchhhhhHHHHHHHHHHHcCCeEEeeeeEEEeccccCCCCCceeeccCCCCCCCcc Confidence 99999999999999755689999999988999999999988999999999999998865322211111122378899999 Q NP_000282.1 314 LDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVS 393 (417) Q Consensus 314 ~DIGp~Ti~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vS 393 (417) +||||+|++.|.+.|++|||||||||||+||.++|++||+++++++++++.+++++|+|||||+++++++|+.++++||| T Consensus 241 lDIGp~Ti~~~~~~I~~aktI~wnGP~G~~E~~~f~~GT~~i~~ai~~~~~~~a~~ivGGGdT~~~~~~~g~~~~~s~vS 320 (416) T 1FW8_A 241 LDNGPESRKLFAATVAKAKTIVWNGPPGVFEFEKFAAGTKALLDEVVKSSAAGNTVIIGGGDTATVAKKYGVTDKISHVS 320 (416) T ss_dssp EEECHHHHHHHHHHHHHCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHHHHTTCEEEECTTHHHHHHHHTTCGGGSSEEC T ss_pred cccCHHHHHHHHHHHHcCCEEEEcCCCCcccccccChHHHHHHHHHHHHhcCCCeEEEechhHHHHHHHhCCCCCceEEe Confidence 99999999999999999999999999999998889999999999997632236899999999999998889878899999 Q NP_000282.1 394 TGGGASLELLEGKVLPGVDALSN 416 (417) Q Consensus 394 tgGgA~Le~L~G~~LPgl~aL~~ 416 (417) |||||+||||+|+.||||++|++ T Consensus 321 TGGGA~Le~L~Gk~LPgieaL~~ 343 (416) T 1FW8_A 321 TGGGASLELLEGKELPGVAFLSE 343 (416) T ss_dssp SCSHHHHHHHTTCCCHHHHTSCS T ss_pred cCchHHHHHHcCCCCCceeehhh Confidence 99999999999999999999985 No 23 >1FW8_A PHOSPHOGLYCERATE KINASE (E.C.2.7.2.3); phosphotransferase, kinase, phosphoglycerate kinase, glycolysis; HET: GOL; 2.3A {Saccharomyces cerevisiae} SCOP: c.86.1.1 Probab=99.28 E-value=3.2e-16 Score=156.69 Aligned_cols=68 Identities=57% Similarity=0.940 Sum_probs=61.4 Template_Neff=6.400 Q NP_000282.1 3 LSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGV 70 (417) Q Consensus 3 ~~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~ 70 (417) ++.++++++.+++|||||||+|+|||+++++|.|++||++++|||+||+++||++||++||+|||+++ T Consensus 347 ~~~~~~~~~~~~~~k~vl~R~D~nvp~~~~~i~d~~Ri~~~~~ti~~l~~~~~~~vii~sH~grp~~~ 414 (416) T 1FW8_A 347 LSSKLSVQDLDLKDKRVFIRVDFNVPLDGKKITSNQRIVAALPTIKYVLEHHPRYVVLASHLGRPNGE 414 (416) T ss_dssp SSCSCBGGGSCCTTCEEEEECCCCCCBSSSSBSCTHHHHHHHHHHHHHHHTCCSEEEEECCCSCCCSS T ss_pred ccccccccccccCCCEEEEEeecCCCCCCCCcCCCHHHHhHHHHHHHHHHcCCCEEEEeeccCCCCCC Confidence 45567777788999999999999999988899999999999999999999998449999999999875 No 24 >2Q33_B D-MONELLIN CHAIN A, D-MONELLIN CHAIN; ALPHA/BETA, ALL-D PROTEIN, DE NOVO; 1.8A {N/A} Probab=34.33 E-value=5.9 Score=24.60 Aligned_cols=11 Identities=36% Similarity=0.761 Sum_probs=9.2 Template_Neff=1.000 Q NP_000282.1 310 GWMGLDCGPES 320 (417) Q Consensus 310 ~~~~~DIGp~T 320 (417) .|.++||||-| T Consensus 2 eweiidigpft 12 (48) T 2Q33_B 2 EWEIIDIGPFT 12 (48) Confidence 58899999955 Query NP_000290.2 Match_columns 747 No_of_seqs 3849 out of 40250 Neff 6.23432 Searched_HMMs 998 Date Fri Jul 24 20:45:58 2020 Command /home/guerler/hh-suite/build/bin/hhblits -i /home/guerler/human/fasta/NP_00/NP_000290.2.fasta -d /home/guerler/pdb70/pdb70 -o /home/guerler/human/hhr/NP_00/NP_000290.2.hhr No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 1XM9_A plakophilin 1 Plakophi 99.7 6.3E-22 7.3E-26 206.9 0.0 453 246-719 3-455 (457) 2 3L6X_A Catenin delta-1, E-cadh 99.4 1.1E-17 1.2E-21 185.5 0.0 438 245-729 48-492 (584) 3 5D5K_C Importin subunit alpha- 98.6 1.1E-11 1.4E-15 126.2 0.0 369 243-713 11-386 (466) 4 3NMZ_A APC variant protein, Rh 98.6 1.3E-11 1.4E-15 129.0 0.0 381 238-715 25-452 (458) 5 4UAF_B Importin alpha 1 import 98.5 1.3E-11 1.6E-15 125.7 0.0 369 243-713 11-386 (466) 6 4U5L_A deltaIBB-importin-alpha 98.5 1.7E-11 2E-15 123.0 0.0 360 246-712 49-425 (426) 7 6SA7_B DARPin-Armadillo fusion 98.5 2.5E-11 2.9E-15 127.0 0.0 136 244-380 172-309 (510) 8 4RV1_D Engineered Protein OR49 98.5 2.7E-11 3.2E-15 120.8 0.0 362 247-715 4-369 (420) 9 6S9O_F designed Armadillo repe 98.5 2.8E-11 3.3E-15 117.9 0.0 167 545-724 170-338 (344) 10 5MFD_C YIIIM''6AII, Capsid dec 98.5 3E-11 3.5E-15 116.2 0.0 318 246-712 5-326 (328) 11 4MZ6_E Deoxyuridine 5'-triphos 98.5 3.5E-11 4E-15 125.0 0.0 368 244-713 56-430 (509) 12 5UMZ_B Importin subunit alpha- 98.5 3.5E-11 4E-15 125.0 0.0 368 244-713 56-430 (509) 13 2JDQ_A IMPORTIN ALPHA-1 SUBUNI 98.4 3.6E-11 4.2E-15 122.1 0.0 367 244-716 19-393 (450) 14 4E4V_A Importin subunit alpha- 98.4 3.6E-11 4.2E-15 124.3 0.0 364 246-716 76-456 (485) 15 4B18_A IMPORTIN SUBUNIT ALPHA- 98.4 4E-11 4.7E-15 121.6 0.0 368 244-717 16-391 (447) 16 4XZR_B Heh1-NLS, Kap60; karyop 98.4 4.3E-11 5E-15 119.8 0.0 363 248-717 4-375 (423) 17 5XZX_A Importin subunit alpha- 98.4 4.3E-11 5.1E-15 119.5 0.0 133 247-380 4-140 (416) 18 1JDH_A BETA-CATENIN, hTcf-4; B 98.4 4.4E-11 5.2E-15 123.9 0.0 378 245-726 101-502 (529) 19 3IFQ_A plakoglobin, E-cadherin 98.4 4.5E-11 5.3E-15 124.5 0.0 381 246-726 104-503 (553) 20 4UAD_A Importin alpha import a 98.4 6E-11 7E-15 121.8 0.0 372 246-723 68-456 (479) 21 5ZHX_D Rap1 GTPase-GDP dissoci 98.4 6.3E-11 7.5E-15 120.9 0.0 407 246-727 19-458 (487) 22 1EE4_A KARYOPHERIN ALPHA; ARM 98.4 8.2E-11 9.6E-15 117.7 0.0 364 247-717 3-375 (423) 23 1EE4_B KARYOPHERIN ALPHA; ARM 98.4 8.2E-11 9.6E-15 117.7 0.0 364 247-717 3-375 (423) 24 4EV8_A Catenin beta-1; mouse c 98.3 9.8E-11 1.2E-14 121.5 0.0 382 246-727 103-504 (538) 25 4RXH_B Importin subunit alpha, 98.3 1.1E-10 1.2E-14 121.7 0.0 365 246-716 72-457 (495) 26 4BQK_A IMPORTIN SUBUNIT ALPHA- 98.3 1.2E-10 1.3E-14 118.5 0.0 366 246-716 46-427 (456) 27 6BW9_A Importin subunit alpha- 98.3 1.3E-10 1.5E-14 118.5 0.0 366 246-717 53-428 (459) 28 1WA5_B GTP-BINDING NUCLEAR PRO 98.3 1.9E-10 2.2E-14 121.4 0.0 134 245-379 173-308 (530) 29 5XGC_A Rap1 GTPase-GDP dissoci 98.3 2E-10 2.3E-14 117.7 0.0 409 246-729 35-476 (503) 30 4BPL_A IMPORTIN SUBUNIT ALPHA- 98.2 2.4E-10 2.9E-14 115.9 0.0 367 246-717 44-426 (454) 31 4B8J_A IMPORTIN SUBUNIT ALPHA- 98.2 2.6E-10 2.9E-14 120.0 0.0 367 246-717 118-500 (528) 32 5T94_B Guanine nucleotide exch 98.2 2.9E-10 3.3E-14 120.5 0.0 364 246-716 131-513 (542) 33 4TNM_A Importin-alpha3 / MOS6; 98.2 3.2E-10 3.7E-14 119.6 0.0 369 246-719 119-504 (531) 34 5TBK_C Importin subunit alpha- 98.2 3.4E-10 3.8E-14 119.3 0.0 366 245-716 71-443 (521) 35 5TBK_D Importin subunit alpha- 98.2 3.4E-10 3.8E-14 119.3 0.0 366 245-716 71-443 (521) 36 2Z6G_A B-catenin; Full-Length, 98.1 6.4E-10 6.8E-14 126.7 0.0 381 245-725 234-634 (780) 37 1JDH_A BETA-CATENIN, hTcf-4; B 98.1 6.1E-10 7.2E-14 115.0 0.0 326 286-717 16-343 (529) 38 2Z6H_A Catenin beta-1; Beta-Ca 98.1 7.3E-10 8.1E-14 121.3 0.0 378 246-673 99-530 (644) 39 6SA8_A ring-like DARPin-Armadi 98.1 7.7E-10 8.7E-14 121.2 0.0 342 244-691 177-522 (671) 40 4RXH_B Importin subunit alpha, 98.1 1.2E-09 1.4E-13 113.4 0.0 157 545-714 196-354 (495) 41 5XJG_A Vacuolar protein 8, Nuc 98.0 1.3E-09 1.5E-13 111.8 0.0 133 246-380 159-293 (506) 42 6KBM_A Vacuolar protein 8, Aut 98.0 1.3E-09 1.5E-13 111.8 0.0 133 246-380 159-293 (506) 43 4TNM_A Importin-alpha3 / MOS6; 98.0 2E-09 2.3E-13 113.3 0.0 158 545-714 243-402 (531) 44 6KBN_A Vacuolar protein 8, Aut 98.0 2.1E-09 2.5E-13 112.9 0.0 133 246-380 153-287 (563) 45 6KBN_C Vacuolar protein 8, Aut 98.0 2.1E-09 2.5E-13 112.9 0.0 133 246-380 153-287 (563) 46 4EV8_A Catenin beta-1; mouse c 98.0 2.1E-09 2.5E-13 111.1 0.0 323 286-716 17-343 (538) 47 4BPL_A IMPORTIN SUBUNIT ALPHA- 98.0 2.2E-09 2.5E-13 108.6 0.0 158 545-714 168-327 (454) 48 4PLS_B Arm00010; PEPTIDE BINDI 98.0 2.5E-09 2.9E-13 100.1 0.0 112 247-359 3-114 (281) 49 5Z8H_A Adenomatous polyposis c 98.0 2.6E-09 3E-13 104.9 0.0 123 258-380 92-219 (339) 50 2Z6H_A Catenin beta-1; Beta-Ca 98.0 2.8E-09 3.1E-13 116.5 0.0 415 246-726 57-499 (644) 51 5AEI_B DESIGNED ARMADILLO REPE 97.9 2.9E-09 3.4E-13 99.9 0.0 114 246-360 5-118 (286) 52 4B8J_A IMPORTIN SUBUNIT ALPHA- 97.9 3.2E-09 3.7E-13 111.3 0.0 160 544-715 199-360 (528) 53 4R10_A Protein humpback-2, Cad 97.9 4.1E-09 4.8E-13 110.8 0.0 417 245-725 73-531 (572) 54 5XJG_A Vacuolar protein 8, Nuc 97.9 4.2E-09 5E-13 107.7 0.0 359 246-716 39-399 (506) 55 6KBM_A Vacuolar protein 8, Aut 97.9 4.2E-09 5E-13 107.7 0.0 359 246-716 39-399 (506) 56 5IZA_A Adenomatous polyposis c 97.9 4.5E-09 5E-13 105.1 0.0 297 236-625 23-335 (354) 57 4R0Z_A Protein humpback-2; arm 97.9 5.4E-09 6.2E-13 112.3 0.0 401 246-718 115-565 (629) 58 4R0Z_A Protein humpback-2; arm 97.9 5.5E-09 6.3E-13 112.2 0.0 418 245-726 73-532 (629) 59 1XM9_A plakophilin 1 Plakophi 97.8 6.1E-09 7E-13 106.4 0.0 350 245-671 44-450 (457) 60 4I2Z_A Protein UNC-45, Heat sh 97.8 7.3E-09 7.1E-13 122.5 0.0 69 247-316 648-716 (961) 61 6SWY_5 Vacuolar import and deg 97.8 7.4E-09 7.2E-13 121.9 0.0 402 240-720 281-784 (921) 62 5IZ8_A Adenomatous polyposis c 97.8 6.6E-09 7.4E-13 103.8 0.0 297 236-625 23-335 (354) 63 3IFQ_A plakoglobin, E-cadherin 97.8 6.4E-09 7.5E-13 107.7 0.0 374 244-725 18-399 (553) 64 4I2W_A Protein UNC-45, Heat sh 97.8 7.9E-09 7.7E-13 122.2 0.0 70 246-316 647-716 (961) 65 4R10_A Protein humpback-2, Cad 97.8 8.7E-09 1E-12 108.2 0.0 398 246-715 115-562 (572) 66 5T94_B Guanine nucleotide exch 97.8 9.3E-09 1.1E-12 108.5 0.0 159 544-715 254-414 (542) 67 6KBN_A Vacuolar protein 8, Aut 97.8 9.2E-09 1.1E-12 107.8 0.0 358 245-714 32-391 (563) 68 6KBN_C Vacuolar protein 8, Aut 97.8 9.2E-09 1.1E-12 107.8 0.0 358 245-714 32-391 (563) 69 2Z6G_A B-catenin; Full-Length, 97.8 1.2E-08 1.3E-12 115.8 0.0 373 244-724 149-529 (780) 70 5EWP_B Uncharacterized protein 97.7 1.3E-08 1.5E-12 96.8 0.0 118 263-381 60-181 (252) 71 5XGC_A Rap1 GTPase-GDP dissoci 97.7 1.3E-08 1.6E-12 103.5 0.0 358 257-715 5-373 (503) 72 6BW9_A Importin subunit alpha- 97.7 1.6E-08 1.9E-12 102.4 0.0 367 244-716 8-381 (459) 73 5D5K_C Importin subunit alpha- 97.7 2E-08 2.4E-12 101.3 0.0 364 246-716 57-437 (466) 74 4UAF_B Importin alpha 1 import 97.6 2.4E-08 2.9E-12 100.7 0.0 364 246-716 57-437 (466) 75 3L6X_A Catenin delta-1, E-cadh 97.6 2.7E-08 2.9E-12 108.4 0.0 364 263-713 26-432 (584) 76 4U5L_A deltaIBB-importin-alpha 97.6 2.9E-08 3.5E-12 98.5 0.0 367 245-713 5-378 (426) 77 4MZ6_E Deoxyuridine 5'-triphos 97.6 3.4E-08 4E-12 101.6 0.0 364 246-716 101-481 (509) 78 5UMZ_B Importin subunit alpha- 97.6 3.4E-08 4E-12 101.6 0.0 364 246-716 101-481 (509) 79 5ZHX_D Rap1 GTPase-GDP dissoci 97.6 3.6E-08 4.2E-12 99.7 0.0 332 282-715 13-357 (487) 80 3NOW_A SD10334p; Armadillo Rep 97.6 3.6E-08 4.2E-12 107.8 0.0 135 244-380 289-431 (810) 81 4EV8_A Catenin beta-1; mouse c 97.5 4.1E-08 4.9E-12 100.9 0.0 137 245-381 267-409 (538) 82 5Z8H_A Adenomatous polyposis c 97.5 4.4E-08 5E-12 95.7 0.0 161 544-716 162-332 (339) 83 3SL9_B Catenin beta-1, B-cell 97.5 4.8E-08 5.5E-12 84.8 0.0 134 245-381 13-150 (167) 84 4E4V_A Importin subunit alpha- 97.5 5E-08 5.7E-12 99.9 0.0 156 546-714 206-363 (485) 85 1WA5_B GTP-BINDING NUCLEAR PRO 97.5 5.1E-08 5.8E-12 102.1 0.0 368 242-716 84-460 (530) 86 1EE4_A KARYOPHERIN ALPHA; ARM 97.5 5.1E-08 6E-12 96.6 0.0 115 245-360 87-201 (423) 87 1EE4_B KARYOPHERIN ALPHA; ARM 97.5 5.1E-08 6E-12 96.6 0.0 115 245-360 87-201 (423) 88 4I2Z_A Protein UNC-45, Heat sh 97.5 6.2E-08 6E-12 114.3 0.0 431 248-725 443-904 (961) 89 5XZX_A Importin subunit alpha- 97.5 6.3E-08 7.4E-12 95.7 0.0 360 246-711 46-415 (416) 90 5MFO_F YIIIM3AIII; Designed ar 97.5 6.9E-08 8.1E-12 85.3 0.0 134 246-380 5-140 (202) 91 3SL9_E Catenin beta-1, B-cell 97.5 7.2E-08 8.3E-12 83.6 0.0 134 245-381 13-150 (167) 92 3NOW_A SD10334p; Armadillo Rep 97.5 7.3E-08 8.5E-12 105.4 0.0 110 247-358 8-120 (810) 93 5MFO_E YIIIM3AIII; Designed ar 97.4 7.9E-08 9.3E-12 84.9 0.0 134 246-380 5-140 (202) 94 4XZR_B Heh1-NLS, Kap60; karyop 97.4 8.1E-08 9.6E-12 95.0 0.0 115 245-360 87-201 (423) 95 3OPB_A SWI5-dependent HO expre 97.4 9.1E-08 9.6E-12 108.6 0.0 168 546-719 544-734 (778) 96 4I2W_A Protein UNC-45, Heat sh 97.4 1E-07 9.8E-12 112.5 0.0 433 247-726 442-905 (961) 97 3TT9_A Plakophilin-2; CELL ADH 97.4 9.1E-08 1E-11 88.5 0.0 221 245-487 8-232 (233) 98 2Z6H_A Catenin beta-1; Beta-Ca 97.4 9.4E-08 1E-11 103.9 0.0 378 241-726 10-395 (644) 99 4U2X_E eVP24, KPNA5C; eVP24, i 97.4 9.4E-08 1.1E-11 83.8 0.0 116 246-362 9-125 (175) 100 4RV1_D Engineered Protein OR49 97.4 9.1E-08 1.1E-11 94.3 0.0 363 246-715 45-411 (420) 101 4BQK_A IMPORTIN SUBUNIT ALPHA- 97.4 9.4E-08 1.1E-11 96.1 0.0 158 545-714 170-329 (456) 102 5TBK_C Importin subunit alpha- 97.4 1E-07 1.2E-11 99.7 0.0 160 544-715 196-357 (521) 103 5TBK_D Importin subunit alpha- 97.4 1E-07 1.2E-11 99.7 0.0 160 544-715 196-357 (521) 104 4U2X_F eVP24, KPNA5C; eVP24, i 97.4 1.2E-07 1.4E-11 83.0 0.0 116 246-362 9-125 (175) 105 4V3Q_A YIII_M4_AII; DE NOVO PR 97.4 1.2E-07 1.4E-11 87.0 0.0 113 247-360 10-122 (247) 106 3NMZ_A APC variant protein, Rh 97.3 1.5E-07 1.7E-11 97.0 0.0 136 245-380 243-389 (458) 107 3L6X_A Catenin delta-1, E-cadh 97.3 1.6E-07 1.7E-11 102.1 0.0 377 246-672 91-522 (584) 108 5MFI_B YIII(Dq.V2)4CqI, (KR)4; 97.3 1.5E-07 1.8E-11 85.8 0.0 113 246-359 5-117 (243) 109 5MFJ_B YIII(Dq.V2)4CqI, (KR)5; 97.3 1.5E-07 1.8E-11 85.8 0.0 113 246-359 5-117 (243) 110 5VOZ_P V-type proton ATPase ca 97.3 2.1E-07 2.1E-11 101.0 0.0 134 246-382 124-281 (478) 111 5D80_H V-type proton ATPase ca 97.3 2.1E-07 2.1E-11 101.0 0.0 134 246-382 124-281 (478) 112 1JDH_A BETA-CATENIN, hTcf-4; B 97.3 1.9E-07 2.2E-11 95.6 0.0 138 245-382 266-409 (529) 113 2Z6G_A B-catenin; Full-Length, 97.3 2.2E-07 2.3E-11 105.1 0.0 353 245-671 276-664 (780) 114 1HO8_A VACUOLAR ATP SYNTHASE S 97.3 2.5E-07 2.5E-11 100.5 0.0 135 245-382 125-283 (480) 115 6S9O_F designed Armadillo repe 97.2 2.9E-07 3.4E-11 88.3 0.0 135 246-381 173-309 (344) 116 1XM9_A plakophilin 1 Plakophi 97.2 3.2E-07 3.6E-11 93.1 0.0 114 246-361 332-451 (457) 117 1XQS_B HSPBP1 protein, Heat sh 97.2 3.3E-07 3.7E-11 87.9 0.0 134 246-380 66-203 (280) 118 5MFI_B YIII(Dq.V2)4CqI, (KR)4; 97.2 3.4E-07 4E-11 83.4 0.0 134 246-380 47-182 (243) 119 5MFJ_B YIII(Dq.V2)4CqI, (KR)5; 97.2 3.4E-07 4E-11 83.4 0.0 134 246-380 47-182 (243) 120 6SA6_A DARPin-Armadillo fusion 97.2 3.9E-07 4.4E-11 91.0 0.0 134 246-380 200-335 (397) 121 6SA8_A ring-like DARPin-Armadi 97.2 4E-07 4.5E-11 98.8 0.0 135 245-380 220-356 (671) 122 1XQR_A HspBP1 protein; armadil 97.1 4.4E-07 4.9E-11 88.9 0.0 134 246-380 82-219 (296) 123 4UAD_A Importin alpha import a 97.1 4.5E-07 5.3E-11 91.8 0.0 368 245-718 23-398 (479) 124 5MFD_C YIIIM''6AII, Capsid dec 97.1 6.1E-07 7.2E-11 84.8 0.0 114 246-360 89-202 (328) 125 6HB3_B Protein HGH1; solenoid 97.1 7E-07 7.2E-11 92.3 0.0 121 246-369 52-208 (369) 126 3OPB_A SWI5-dependent HO expre 97.1 7.2E-07 7.6E-11 100.9 0.0 156 546-711 605-776 (778) 127 4HXT_A De Novo Protein OR329; 97.0 7.7E-07 9.1E-11 80.9 0.0 113 247-360 4-116 (252) 128 3GQ2_A General vesicular trans 97.0 9.1E-07 9.4E-11 98.4 0.0 136 245-381 60-219 (651) 129 3GRL_A General vesicular trans 97.0 9.1E-07 9.4E-11 98.4 0.0 136 245-381 60-219 (651) 130 4HXT_A De Novo Protein OR329; 97.0 8.1E-07 9.6E-11 80.7 0.0 114 246-360 45-158 (252) 131 4PLS_B Arm00010; PEPTIDE BINDI 97.0 8.3E-07 9.9E-11 82.1 0.0 114 246-360 44-157 (281) 132 5IZA_A Adenomatous polyposis c 97.0 9.5E-07 1.1E-10 87.4 0.0 114 245-358 127-246 (354) 133 5IZ8_A Adenomatous polyposis c 97.0 1E-06 1.1E-10 87.2 0.0 113 246-358 128-246 (354) 134 6SA7_B DARPin-Armadillo fusion 97.0 1.1E-06 1.2E-10 90.6 0.0 135 246-381 342-478 (510) 135 4V3Q_A YIII_M4_AII; DE NOVO PR 97.0 1.1E-06 1.3E-10 80.3 0.0 135 245-380 92-228 (247) 136 5Z8H_A Adenomatous polyposis c 96.9 1.2E-06 1.4E-10 85.0 0.0 134 245-379 122-267 (339) 137 5AEI_B DESIGNED ARMADILLO REPE 96.9 1.4E-06 1.7E-10 80.6 0.0 112 246-358 173-284 (286) 138 5IZA_A Adenomatous polyposis c 96.9 1.5E-06 1.7E-10 85.8 0.0 124 258-381 97-225 (354) 139 5IZ8_A Adenomatous polyposis c 96.9 1.6E-06 1.8E-10 85.8 0.0 124 258-381 97-225 (354) 140 3NMZ_A APC variant protein, Rh 96.9 1.6E-06 1.8E-10 88.9 0.0 135 246-381 287-432 (458) 141 6SA7_B DARPin-Armadillo fusion 96.9 1.6E-06 1.9E-10 89.2 0.0 134 246-380 300-435 (510) 142 5TBK_C Importin subunit alpha- 96.9 1.7E-06 1.9E-10 90.0 0.0 367 246-718 115-491 (521) 143 5TBK_D Importin subunit alpha- 96.9 1.7E-06 1.9E-10 90.0 0.0 367 246-718 115-491 (521) 144 6HB1_A Protein HGH1; solenoid 96.9 1.8E-06 1.9E-10 89.0 0.0 169 547-723 51-256 (369) 145 6HB2_D Protein HGH1; solenoid 96.9 1.8E-06 1.9E-10 89.0 0.0 169 547-723 51-256 (369) 146 5MFD_C YIIIM''6AII, Capsid dec 96.8 1.8E-06 2.1E-10 81.5 0.0 114 246-360 47-160 (328) 147 6SA7_B DARPin-Armadillo fusion 96.8 1.8E-06 2.1E-10 88.8 0.0 115 246-361 384-498 (510) 148 6S9O_F designed Armadillo repe 96.8 2.5E-06 2.9E-10 81.5 0.0 115 245-360 46-160 (344) 149 1XM9_A plakophilin 1 Plakophi 96.8 2.5E-06 2.9E-10 86.1 0.0 167 543-716 82-316 (457) 150 4HXT_A De Novo Protein OR329; 96.8 2.5E-06 2.9E-10 77.3 0.0 114 246-360 129-242 (252) 151 6SA6_A DARPin-Armadillo fusion 96.7 3E-06 3.4E-10 84.2 0.0 132 248-380 160-293 (397) 152 3NMZ_A APC variant protein, Rh 96.7 3.3E-06 3.7E-10 86.5 0.0 135 246-380 190-340 (458) 153 6HB1_A Protein HGH1; solenoid 96.6 5.3E-06 5.5E-10 85.4 0.0 93 287-381 9-108 (369) 154 6HB2_D Protein HGH1; solenoid 96.6 5.3E-06 5.5E-10 85.4 0.0 93 287-381 9-108 (369) 155 2W3C_A GENERAL VESICULAR TRANS 96.6 5.7E-06 5.9E-10 90.0 0.0 135 246-381 71-213 (577) 156 4XZR_B Heh1-NLS, Kap60; karyop 96.6 5.2E-06 6.2E-10 81.4 0.0 114 246-360 172-285 (423) 157 3TT9_A Plakophilin-2; CELL ADH 96.6 6E-06 6.8E-10 75.6 0.0 136 246-382 53-206 (233) 158 6HB3_B Protein HGH1; solenoid 96.6 6.6E-06 6.8E-10 84.6 0.0 93 287-381 9-108 (369) 159 6SA8_A ring-like DARPin-Armadi 96.5 6.4E-06 7.1E-10 88.9 0.0 322 286-714 177-502 (671) 160 1EE4_A KARYOPHERIN ALPHA; ARM 96.5 6.8E-06 8.1E-10 80.5 0.0 114 246-360 214-327 (423) 161 1EE4_B KARYOPHERIN ALPHA; ARM 96.5 6.8E-06 8.1E-10 80.5 0.0 114 246-360 214-327 (423) 162 5KC2_B Phosphatidylinositol 3- 96.5 9.9E-06 1E-09 98.5 0.0 150 546-715 618-768 (1454) 163 4B18_A IMPORTIN SUBUNIT ALPHA- 96.4 8.9E-06 1E-09 80.7 0.0 366 245-716 61-443 (447) 164 1JDH_A BETA-CATENIN, hTcf-4; B 96.4 9E-06 1.1E-09 82.5 0.0 363 245-712 143-529 (529) 165 5MFI_B YIII(Dq.V2)4CqI, (KR)4; 96.4 9.2E-06 1.1E-09 73.3 0.0 135 245-380 88-224 (243) 166 5MFJ_B YIII(Dq.V2)4CqI, (KR)5; 96.4 9.2E-06 1.1E-09 73.3 0.0 135 245-380 88-224 (243) 167 4MFU_A Beta-catenin-like prote 96.4 1.1E-05 1.1E-09 87.3 0.0 182 539-725 60-261 (490) 168 5AEI_B DESIGNED ARMADILLO REPE 96.4 1E-05 1.2E-09 74.6 0.0 134 246-380 89-224 (286) 169 4PLS_B Arm00010; PEPTIDE BINDI 96.4 1.1E-05 1.3E-09 74.1 0.0 111 246-357 170-280 (281) 170 4HM9_A Beta-catenin-like prote 96.4 1.4E-05 1.3E-09 88.6 0.0 181 539-725 138-339 (568) 171 3L6X_A Catenin delta-1, E-cadh 96.4 1.3E-05 1.4E-09 86.3 0.0 135 246-381 236-406 (584) 172 4U5L_A deltaIBB-importin-alpha 96.4 1.2E-05 1.4E-09 78.7 0.0 134 246-380 223-359 (426) 173 2JDQ_A IMPORTIN ALPHA-1 SUBUNI 96.3 1.3E-05 1.5E-09 79.6 0.0 366 245-716 64-446 (450) 174 3GQ2_A General vesicular trans 96.3 1.5E-05 1.5E-09 88.2 0.0 169 543-721 204-403 (651) 175 3GRL_A General vesicular trans 96.3 1.5E-05 1.5E-09 88.2 0.0 169 543-721 204-403 (651) 176 3TT9_A Plakophilin-2; CELL ADH 96.3 1.5E-05 1.7E-09 72.9 0.0 113 246-360 95-230 (233) 177 5D5K_C Importin subunit alpha- 96.3 1.5E-05 1.8E-09 79.2 0.0 113 246-359 273-386 (466) 178 4UAF_B Importin alpha 1 import 96.3 1.6E-05 1.8E-09 79.1 0.0 113 246-359 273-386 (466) 179 2JDQ_A IMPORTIN ALPHA-1 SUBUNI 96.2 1.8E-05 2.2E-09 78.4 0.0 134 246-380 235-371 (450) 180 3IFQ_A plakoglobin, E-cadherin 96.2 1.8E-05 2.2E-09 80.6 0.0 367 245-716 145-534 (553) 181 4BQK_A IMPORTIN SUBUNIT ALPHA- 96.2 1.9E-05 2.2E-09 78.5 0.0 116 245-360 172-287 (456) 182 4U5L_A deltaIBB-importin-alpha 96.2 2.2E-05 2.6E-09 76.7 0.0 115 245-360 180-294 (426) 183 4BPL_A IMPORTIN SUBUNIT ALPHA- 96.2 2.3E-05 2.7E-09 77.8 0.0 135 245-379 170-306 (454) 184 4MZ6_E Deoxyuridine 5'-triphos 96.1 2.6E-05 3.1E-09 79.0 0.0 113 246-359 317-430 (509) 185 5UMZ_B Importin subunit alpha- 96.1 2.6E-05 3.1E-09 79.0 0.0 113 246-359 317-430 (509) 186 4E4V_A Importin subunit alpha- 96.1 2.7E-05 3.1E-09 78.7 0.0 113 246-359 292-405 (485) 187 3GQ2_A General vesicular trans 96.1 3.4E-05 3.5E-09 85.2 0.0 176 543-726 56-255 (651) 188 3GRL_A General vesicular trans 96.1 3.4E-05 3.5E-09 85.2 0.0 176 543-726 56-255 (651) 189 4V3Q_A YIII_M4_AII; DE NOVO PR 96.0 3.4E-05 4E-09 69.7 0.0 112 246-358 135-246 (247) 190 4TNM_A Importin-alpha3 / MOS6; 96.0 3.5E-05 4E-09 79.5 0.0 136 245-380 245-382 (531) 191 4GMO_A Putative uncharacterize 95.9 5.4E-05 5.2E-09 85.2 0.0 94 245-339 34-129 (684) 192 4PLS_B Arm00010; PEPTIDE BINDI 95.9 4.9E-05 5.8E-09 69.4 0.0 134 246-380 86-221 (281) 193 5MFO_F YIIIM3AIII; Designed ar 95.9 5E-05 5.9E-09 65.8 0.0 112 246-358 89-200 (202) 194 2RU4_A Armadillo Repeat Protei 95.9 5.2E-05 6E-09 59.8 0.0 110 248-358 4-113 (115) 195 5AEI_B DESIGNED ARMADILLO REPE 95.9 5.1E-05 6.1E-09 69.5 0.0 114 246-360 47-160 (286) 196 5MFD_C YIIIM''6AII, Capsid dec 95.9 5.1E-05 6.1E-09 70.8 0.0 157 545-714 128-286 (328) 197 5MFO_E YIIIM3AIII; Designed ar 95.9 5.2E-05 6.2E-09 65.7 0.0 112 246-358 89-200 (202) 198 5D5K_C Importin subunit alpha- 95.8 5.5E-05 6.5E-09 74.9 0.0 158 544-714 138-302 (466) 199 1XQS_B HSPBP1 protein, Heat sh 95.8 5.9E-05 6.6E-09 71.4 0.0 116 246-362 109-225 (280) 200 4UAF_B Importin alpha 1 import 95.8 5.9E-05 7E-09 74.7 0.0 158 544-714 138-302 (466) 201 1XQR_A HspBP1 protein; armadil 95.8 6.4E-05 7E-09 72.7 0.0 116 246-362 125-241 (296) 202 6CRI_R Bone marrow stromal ant 95.8 6.2E-05 7.1E-09 78.2 0.0 151 547-721 414-577 (585) 203 6SA8_A ring-like DARPin-Armadi 95.8 6.8E-05 7.7E-09 80.4 0.0 136 245-381 262-399 (671) 204 5WBJ_A Regulatory-associated p 95.8 8.1E-05 7.9E-09 89.5 0.0 168 541-715 500-672 (1287) 205 5Z8H_A Adenomatous polyposis c 95.7 7.4E-05 8.5E-09 71.6 0.0 115 246-361 210-331 (339) 206 5WBK_A Regulatory-associated p 95.7 9.2E-05 9E-09 89.0 0.0 168 541-715 500-672 (1287) 207 6SA6_A DARPin-Armadillo fusion 95.7 8.4E-05 9.6E-09 73.2 0.0 135 245-380 241-377 (397) 208 2W3C_A GENERAL VESICULAR TRANS 95.6 0.00012 1.2E-08 79.1 0.0 136 246-382 9-168 (577) 209 6CRI_I Bone marrow stromal ant 95.6 0.0001 1.2E-08 74.8 0.0 106 244-360 72-177 (570) 210 1QBK_B STRUCTURE OF THE KARYOP 95.6 0.00011 1.3E-08 79.3 0.0 157 547-715 667-824 (890) 211 4P6Z_G BST2/tetherin, HIV-1 Vp 95.6 0.00012 1.3E-08 77.7 0.0 151 547-721 431-594 (627) 212 5MFI_B YIII(Dq.V2)4CqI, (KR)4; 95.5 0.00014 1.6E-08 65.0 0.0 112 246-358 131-242 (243) 213 5MFJ_B YIII(Dq.V2)4CqI, (KR)5; 95.5 0.00014 1.6E-08 65.0 0.0 112 246-358 131-242 (243) 214 5EWP_B Uncharacterized protein 95.4 0.00015 1.7E-08 67.3 0.0 134 246-380 87-233 (252) 215 4V3Q_A YIII_M4_AII; DE NOVO PR 95.4 0.00017 2E-08 64.8 0.0 134 246-380 51-186 (247) 216 3GQ2_A General vesicular trans 95.3 0.00022 2.3E-08 78.3 0.0 135 246-381 123-265 (651) 217 3GRL_A General vesicular trans 95.3 0.00022 2.3E-08 78.3 0.0 135 246-381 123-265 (651) 218 5AFF_A SYMPORTIN 1, RIBOSOMAL 95.2 0.00026 2.6E-08 78.8 0.0 94 245-339 12-107 (654) 219 6QH5_B AP-2 complex subunit al 95.2 0.00023 2.7E-08 73.0 0.0 107 243-360 84-190 (592) 220 3C2G_A Sys-1 protein, Pop-1 8- 95.2 0.00033 2.8E-08 77.7 0.0 189 260-486 185-412 (619) 221 4FDD_A Transportin-1, RNA-bind 95.1 0.00028 3.3E-08 75.3 0.0 157 547-715 629-786 (852) 222 4P6Z_B BST2/tetherin, HIV-1 Vp 95.0 0.00031 3.6E-08 72.5 0.0 106 244-360 101-206 (600) 223 2JKT_A AP-2 COMPLEX SUBUNIT AL 95.0 0.00032 3.7E-08 73.5 0.0 144 547-714 441-590 (623) 224 5IZ8_A Adenomatous polyposis c 95.0 0.00036 4.1E-08 67.8 0.0 162 543-716 166-337 (354) 225 5IZA_A Adenomatous polyposis c 94.9 0.00036 4.1E-08 67.8 0.0 162 543-716 166-337 (354) 226 5YVI_A Transportin-1, RNA-bind 94.9 0.00036 4.3E-08 74.5 0.0 156 547-714 645-801 (868) 227 6QH7_A AP-2 complex subunit al 94.9 0.00038 4.3E-08 73.0 0.0 108 242-360 108-217 (621) 228 1B3U_A PROTEIN PHOSPHATASE PP2 94.9 0.0004 4.8E-08 70.1 0.0 146 547-712 441-586 (588) 229 4HM9_A Beta-catenin-like prote 94.8 0.00057 5.4E-08 75.0 0.0 161 543-716 241-424 (568) 230 6QH5_A AP-2 complex subunit al 94.8 0.00048 5.5E-08 72.2 0.0 144 548-715 442-591 (621) 231 5MFO_F YIIIM3AIII; Designed ar 94.7 0.00052 6.2E-08 58.9 0.0 134 246-380 47-182 (202) 232 5MFO_E YIIIM3AIII; Designed ar 94.7 0.00054 6.3E-08 58.8 0.0 134 246-380 47-182 (202) 233 4MFU_A Beta-catenin-like prote 94.6 0.00067 6.6E-08 72.8 0.0 161 543-716 163-346 (490) 234 2NYL_A Protein phosphatase 2, 94.6 0.00059 7.1E-08 68.5 0.0 145 548-712 436-580 (582) 235 4U2X_F eVP24, KPNA5C; eVP24, i 94.4 0.00082 9.5E-08 57.1 0.0 73 246-318 51-124 (175) 236 3SL9_B Catenin beta-1, B-cell 94.3 0.00082 9.5E-08 56.5 0.0 110 246-357 56-166 (167) 237 4I5L_D PP2A A alpha subunit (9 94.3 0.0008 9.6E-08 67.6 0.0 110 246-359 239-349 (584) 238 4U2X_E eVP24, KPNA5C; eVP24, i 94.3 0.00091 1E-07 56.8 0.0 73 246-318 51-124 (175) 239 4UQI_B AP-2 COMPLEX SUBUNIT AL 94.2 0.00095 1.1E-07 70.3 0.0 106 244-360 85-190 (657) 240 5KC2_B Phosphatidylinositol 3- 94.0 0.0013 1.4E-07 79.1 0.0 155 544-715 506-689 (1454) 241 3SL9_E Catenin beta-1, B-cell 94.0 0.0012 1.4E-07 55.4 0.0 110 246-357 56-166 (167) 242 3VWA_B Cytoplasmic export prot 93.8 0.0017 1.8E-07 68.9 0.0 150 546-714 379-529 (560) 243 5DFZ_B Vacuolar protein sortin 93.7 0.0018 1.8E-07 77.7 0.0 155 546-719 608-762 (1460) 244 6HWP_A A3_bGFPD; alphaRep, art 93.7 0.0016 1.9E-07 62.8 0.0 91 245-358 23-113 (409) 245 3TT9_A Plakophilin-2; CELL ADH 93.7 0.0017 1.9E-07 58.2 0.0 169 542-716 47-232 (233) 246 3VWA_A Cytoplasmic export prot 93.6 0.0019 2E-07 68.6 0.0 152 545-715 378-530 (560) 247 1XQR_A HspBP1 protein; armadil 93.6 0.0019 2.1E-07 61.7 0.0 122 257-380 52-177 (296) 248 1XQS_B HSPBP1 protein, Heat sh 93.4 0.0023 2.6E-07 59.7 0.0 123 257-380 36-161 (280) 249 5VOZ_P V-type proton ATPase ca 93.3 0.0027 2.7E-07 67.5 0.0 330 290-714 78-475 (478) 250 5D80_H V-type proton ATPase ca 93.3 0.0027 2.7E-07 67.5 0.0 330 290-714 78-475 (478) 251 1F59_B IMPORTIN BETA-1/FXFG NU 93.3 0.0024 2.8E-07 62.2 0.0 154 549-713 261-437 (442) 252 6XTE_A Importin-5, antipain; h 93.2 0.0025 2.9E-07 70.4 0.0 153 548-714 358-521 (1096) 253 4HXT_A De Novo Protein OR329; 93.2 0.0025 3E-07 56.2 0.0 134 246-380 87-222 (252) 254 5IFE_C Splicing factor 3B subu 93.2 0.0029 3E-07 75.0 0.0 153 548-714 932-1087(1304) 255 6AHD_1 Pre-mRNA-processing-spl 93.2 0.0029 3E-07 75.0 0.0 153 548-714 932-1087(1304) 256 6QH5_B AP-2 complex subunit al 93.1 0.0027 3.1E-07 64.6 0.0 146 548-714 428-573 (592) 257 6EN4_C Splicing factor 3B subu 92.9 0.0031 3.6E-07 67.4 0.0 154 548-714 480-635 (852) 258 6SA6_A DARPin-Armadillo fusion 92.9 0.0032 3.7E-07 61.0 0.0 112 246-358 284-395 (397) 259 6FT5_A A3_A3; alphaRep, artifi 92.9 0.0032 3.7E-07 60.7 0.0 91 245-358 23-113 (409) 260 3C5W_A PP2A A subunit, PP2A C; 92.9 0.0032 3.8E-07 54.7 0.0 146 548-713 86-231 (232) 261 4LAC_A Serine/threonine-protei 92.9 0.0033 3.8E-07 56.3 0.0 110 545-670 31-140 (258) 262 4FDD_A Transportin-1, RNA-bind 92.6 0.0039 4.6E-07 65.8 0.0 150 548-712 360-511 (852) 263 5NR4_A CLIP-associating protei 92.6 0.004 4.6E-07 54.4 0.0 148 548-715 53-200 (230) 264 3C5W_A PP2A A subunit, PP2A C; 92.5 0.0041 4.8E-07 53.9 0.0 107 548-670 8-114 (232) 265 6XU2_A Importin-5, antipain; h 92.5 0.0042 4.9E-07 68.8 0.0 152 548-713 377-539 (1115) 266 4LAC_A Serine/threonine-protei 92.5 0.0043 5E-07 55.5 0.0 146 548-713 112-257 (258) 267 6EN4_C Splicing factor 3B subu 92.5 0.0043 5E-07 66.2 0.0 147 547-714 675-823 (852) 268 1QBK_B STRUCTURE OF THE KARYOP 92.4 0.0043 5.1E-07 66.1 0.0 151 548-713 398-550 (890) 269 6CRI_I Bone marrow stromal ant 92.4 0.0043 5.1E-07 62.1 0.0 145 548-714 415-560 (570) 270 2RU4_B Armadillo Repeat Protei 92.4 0.0045 5.2E-07 45.3 0.0 71 287-358 12-82 (84) 271 4L7M_A Putative uncharacterize 92.3 0.0047 5.5E-07 55.6 0.0 75 545-625 35-109 (269) 272 5WBJ_A Regulatory-associated p 92.2 0.0059 5.8E-07 72.7 0.0 100 561-671 612-725 (1287) 273 5WBK_A Regulatory-associated p 92.2 0.0059 5.8E-07 72.7 0.0 101 560-671 611-725 (1287) 274 2QK2_A LP04448p; Mini spindles 92.2 0.005 5.8E-07 54.5 0.0 145 548-714 16-163 (242) 275 3W3U_A Importin subunit beta-3 92.2 0.005 5.8E-07 67.5 0.0 115 245-360 397-512 (1078) 276 2IW3_B ELONGATION FACTOR 3A; A 92.0 0.0058 6.5E-07 68.1 0.0 148 548-713 176-324 (986) 277 4G3A_B CLIP-associating protei 91.9 0.0059 6.8E-07 54.0 0.0 150 547-714 7-158 (237) 278 5EWP_B Uncharacterized protein 91.9 0.0062 6.9E-07 55.7 0.0 176 528-716 7-209 (252) 279 4QMI_B Cytoskeleton-associated 91.9 0.006 6.9E-07 54.1 0.0 147 548-715 60-208 (240) 280 4QMJ_A Cytoskeleton-associated 91.9 0.006 6.9E-07 54.1 0.0 147 548-715 60-208 (240) 281 5XAH_A Importin-4; Histone, Ch 91.8 0.0062 7.2E-07 58.5 0.0 153 548-714 235-389 (416) 282 5XAH_C Importin-4; Histone, Ch 91.8 0.0062 7.2E-07 58.5 0.0 153 548-714 235-389 (416) 283 2QK1_A Protein STU2; stu2, Stu 91.8 0.0063 7.3E-07 53.8 0.0 152 548-714 17-176 (249) 284 5H2V_A Importin subunit beta-3 91.8 0.0063 7.4E-07 66.7 0.0 114 246-360 398-512 (1078) 285 6OWT_A AP-2 complex subunit al 91.7 0.0072 7.8E-07 67.7 0.0 142 548-713 442-589 (939) 286 2P8Q_A Importin beta-1 subunit 91.7 0.0066 7.8E-07 64.5 0.0 160 548-715 650-829 (876) 287 5MFO_F YIIIM3AIII; Designed ar 91.6 0.0068 8E-07 51.3 0.0 157 546-715 3-161 (202) 288 5MFO_E YIIIM3AIII; Designed ar 91.6 0.007 8.3E-07 51.2 0.0 157 546-715 3-161 (202) 289 2QNA_A Importin subunit beta-1 91.5 0.0073 8.6E-07 62.8 0.0 159 548-714 525-703 (762) 290 6G4J_B Probable serine/threoni 91.5 0.008 8.8E-07 50.6 0.0 132 548-723 15-146 (148) 291 3W3W_A Importin subunit beta-3 91.3 0.0081 9.5E-07 65.7 0.0 98 609-715 821-920 (1078) 292 3ND2_A Importin subunit beta-1 91.2 0.0083 9.8E-07 63.2 0.0 152 548-713 598-763 (861) 293 5OWU_A Importin subunit beta-1 91.2 0.0083 9.8E-07 63.2 0.0 152 548-713 598-763 (861) 294 5DFZ_B Vacuolar protein sortin 91.0 0.011 1.1E-06 70.6 0.0 159 546-714 463-639 (1460) 295 3W3U_A Importin subunit beta-3 90.7 0.011 1.3E-06 64.7 0.0 157 548-713 440-600 (1078) 296 1QGR_A IMPORTIN BETA SUBUNIT, 90.6 0.011 1.3E-06 62.8 0.0 113 246-360 367-480 (876) 297 4QMH_A LP04448p; PROTEIN BINDI 90.4 0.012 1.4E-06 51.8 0.0 149 548-715 58-209 (241) 298 5A1V_E ADP-RIBOSYLATION FACTOR 90.4 0.013 1.4E-06 64.9 0.0 102 244-359 67-168 (874) 299 5NZR_G Coatomer subunit alpha, 90.4 0.013 1.4E-06 64.9 0.0 102 244-359 67-168 (874) 300 3W3W_A Importin subunit beta-3 90.3 0.013 1.5E-06 64.1 0.0 157 547-714 439-601 (1078) 301 5H2V_A Importin subunit beta-3 90.2 0.013 1.5E-06 64.0 0.0 158 547-714 439-601 (1078) 302 4NEE_G AP-2 complex subunit si 90.1 0.014 1.6E-06 56.7 0.0 141 548-714 77-219 (398) 303 6MQ5_A CLIP-associating protei 90.0 0.015 1.7E-06 52.9 0.0 111 548-670 4-120 (257) 304 4UQI_B AP-2 COMPLEX SUBUNIT AL 90.0 0.015 1.7E-06 60.6 0.0 109 245-359 160-268 (657) 305 4XRI_A Importin Beta; Transpor 89.9 0.014 1.7E-06 61.5 0.0 159 548-715 651-826 (882) 306 4NEE_B AP-2 complex subunit si 89.8 0.016 1.8E-06 56.6 0.0 141 548-714 77-219 (398) 307 6EN4_C Splicing factor 3B subu 89.8 0.015 1.8E-06 61.6 0.0 153 548-714 397-551 (852) 308 5A1V_E ADP-RIBOSYLATION FACTOR 89.6 0.018 1.9E-06 63.8 0.0 141 548-714 397-538 (874) 309 5NZR_G Coatomer subunit alpha, 89.6 0.018 1.9E-06 63.8 0.0 141 548-714 397-538 (874) 310 6OWT_A AP-2 complex subunit al 89.5 0.018 2E-06 64.2 0.0 98 250-360 79-178 (939) 311 5KC2_B Phosphatidylinositol 3- 89.3 0.021 2.1E-06 68.3 0.0 151 548-714 424-610 (1454) 312 2P8Q_A Importin beta-1 subunit 89.3 0.018 2.1E-06 60.9 0.0 154 548-714 367-538 (876) 313 2QNA_A Importin subunit beta-1 89.1 0.019 2.3E-06 59.4 0.0 115 245-360 3-122 (762) 314 1IBR_B RAN IMPORTIN BETA SUBU 89.1 0.019 2.3E-06 55.6 0.0 154 548-714 129-289 (462) 315 1QGR_A IMPORTIN BETA SUBUNIT, 88.9 0.021 2.4E-06 60.6 0.0 154 548-714 367-538 (876) 316 2DB0_A 253aa long hypothetical 88.9 0.021 2.4E-06 50.5 0.0 141 548-715 108-248 (253) 317 2DB0_B 253aa long hypothetical 88.9 0.021 2.4E-06 50.5 0.0 141 548-715 108-248 (253) 318 4K92_B CLIP-associating protei 88.8 0.022 2.5E-06 52.5 0.0 148 548-714 90-237 (273) 319 6MQ7_B CLIP-associating protei 88.8 0.022 2.5E-06 52.5 0.0 148 548-714 90-237 (273) 320 1GCJ_B IMPORTIN-BETA; HEAT REP 88.7 0.022 2.5E-06 55.4 0.0 154 548-714 135-295 (460) 321 1F59_B IMPORTIN BETA-1/FXFG NU 88.7 0.022 2.6E-06 54.8 0.0 154 548-714 129-289 (442) 322 1UKL_A Importin beta-1 subunit 88.6 0.022 2.6E-06 60.2 0.0 113 246-360 367-480 (876) 323 1U6G_C Cullin homolog 1, RING- 88.2 0.025 2.9E-06 62.9 0.0 146 548-714 891-1036(1230) 324 4MFU_A Beta-catenin-like prote 88.1 0.031 3.1E-06 59.1 0.0 135 246-381 69-222 (490) 325 6CRI_I Bone marrow stromal ant 87.6 0.03 3.5E-06 55.5 0.0 141 548-714 37-177 (570) 326 3QML_D 78 kDa glucose-regulate 87.5 0.038 3.6E-06 55.4 0.0 165 534-712 56-246 (315) 327 5IFE_C Splicing factor 3B subu 87.4 0.036 3.7E-06 65.2 0.0 154 547-714 848-1003(1304) 328 6AHD_1 Pre-mRNA-processing-spl 87.4 0.036 3.7E-06 65.2 0.0 154 547-714 848-1003(1304) 329 5MU7_A Coatomer subunit beta, 87.4 0.031 3.7E-06 52.4 0.0 141 549-716 190-331 (373) 330 5VE8_B Kap123, Histone H3; Bid 87.4 0.031 3.7E-06 61.1 0.0 154 549-714 868-1034(1116) 331 2IX8_A ELONGATION FACTOR 3A; N 87.3 0.034 3.8E-06 61.3 0.0 150 547-713 48-198 (976) 332 3WOY_A CLIP-associating protei 87.3 0.034 3.8E-06 50.1 0.0 147 548-714 78-225 (251) 333 5DN7_A Protein FAM179B; TOG do 87.2 0.035 3.9E-06 52.0 0.0 146 548-714 67-212 (293) 334 4HM9_A Beta-catenin-like prote 87.2 0.04 3.9E-06 59.6 0.0 135 246-381 147-300 (568) 335 6S47_Bi 60S ribosomal protein 87.2 0.035 3.9E-06 61.2 0.0 155 546-713 42-198 (972) 336 6QH5_B AP-2 complex subunit al 87.1 0.034 4E-06 55.8 0.0 142 548-715 50-191 (592) 337 5A1V_G ADP-RIBOSYLATION FACTOR 87.1 0.037 4E-06 61.9 0.0 105 547-670 259-364 (968) 338 3TJZ_B ADP-ribosylation factor 87.0 0.036 4.1E-06 52.5 0.0 16 697-712 225-240 (355) 339 2IW3_B ELONGATION FACTOR 3A; A 86.9 0.037 4.1E-06 61.1 0.0 151 547-714 54-205 (986) 340 5NZR_B Coatomer subunit alpha, 86.8 0.04 4.3E-06 61.6 0.0 105 547-670 259-364 (968) 341 4P6Z_B BST2/tetherin, HIV-1 Vp 86.8 0.037 4.3E-06 55.9 0.0 142 548-715 66-207 (600) 342 5VCH_A Kap123; Bidding yeast k 86.7 0.038 4.4E-06 60.5 0.0 153 550-714 869-1034(1116) 343 6BCU_A mTOR, Target of rapamyc 86.7 0.04 4.4E-06 67.9 0.0 131 549-694 952-1084(2549) 344 6BCX_B mTOR, Target of rapamyc 86.7 0.04 4.4E-06 67.9 0.0 131 549-694 952-1084(2549) 345 5IFE_C Splicing factor 3B subu 86.4 0.045 4.7E-06 64.2 0.0 110 249-359 935-1044(1304) 346 6AHD_1 Pre-mRNA-processing-spl 86.4 0.045 4.7E-06 64.2 0.0 110 249-359 935-1044(1304) 347 6LTJ_L Histone H3.2, Histone H 86.4 0.056 4.7E-06 63.5 0.0 152 563-723 1065-1263(1295) 348 6CRI_R Bone marrow stromal ant 86.2 0.043 4.9E-06 55.5 0.0 139 548-714 63-201 (585) 349 5DFZ_B Vacuolar protein sortin 85.9 0.051 5.3E-06 64.4 0.0 292 245-645 464-781 (1460) 350 2QNA_A Importin subunit beta-1 85.8 0.046 5.4E-06 56.3 0.0 154 548-714 4-164 (762) 351 3WOZ_C CLIP-associating protei 85.7 0.049 5.4E-06 48.6 0.0 154 547-716 5-159 (232) 352 3WOZ_D CLIP-associating protei 85.7 0.049 5.4E-06 48.6 0.0 154 547-716 5-159 (232) 353 5DCQ_C artificial repeat prote 85.5 0.051 5.7E-06 45.4 0.0 47 654-712 120-166 (170) 354 4L7M_A Putative uncharacterize 85.3 0.051 6E-06 48.1 0.0 143 548-713 120-265 (269) 355 4P6Z_B BST2/tetherin, HIV-1 Vp 85.1 0.053 6.2E-06 54.6 0.0 109 245-359 176-284 (600) 356 5MU7_A Coatomer subunit beta, 85.1 0.053 6.2E-06 50.7 0.0 101 598-714 191-292 (373) 357 4UQI_B AP-2 COMPLEX SUBUNIT AL 85.0 0.056 6.3E-06 55.9 0.0 142 548-715 50-191 (657) 358 6MZE_Z Tubulin alpha-1A chain, 84.9 0.055 6.4E-06 53.4 0.0 149 548-715 340-496 (536) 359 4MFU_A Beta-catenin-like prote 84.8 0.067 6.5E-06 56.4 0.0 117 610-733 42-175 (490) 360 5N3U_B Phycocyanobilin lyase s 84.6 0.06 6.9E-06 46.1 0.0 135 547-714 32-167 (208) 361 6QH5_B AP-2 complex subunit al 84.4 0.06 7E-06 53.8 0.0 145 548-713 122-268 (592) 362 2DB0_A 253aa long hypothetical 84.4 0.062 7.1E-06 47.2 0.0 104 547-670 32-136 (253) 363 2DB0_B 253aa long hypothetical 84.4 0.062 7.1E-06 47.2 0.0 104 547-670 32-136 (253) 364 2JKT_A AP-2 COMPLEX SUBUNIT AL 84.2 0.064 7.3E-06 54.8 0.0 140 548-713 75-216 (623) 365 3LTJ_A AlphaRep-4; protein eng 84.1 0.065 7.5E-06 45.7 0.0 28 685-713 140-167 (201) 366 4P6Z_B BST2/tetherin, HIV-1 Vp 84.1 0.065 7.5E-06 54.0 0.0 145 548-713 138-284 (600) 367 6QH7_A AP-2 complex subunit al 84.0 0.067 7.6E-06 54.8 0.0 140 548-713 75-216 (621) 368 6CRI_R Bone marrow stromal ant 83.9 0.067 7.7E-06 53.9 0.0 67 548-625 135-201 (585) 369 4UQI_B AP-2 COMPLEX SUBUNIT AL 83.9 0.069 7.8E-06 55.2 0.0 145 548-713 122-268 (657) 370 5XAH_A Importin-4; Histone, Ch 83.5 0.071 8.2E-06 50.5 0.0 142 561-715 163-307 (416) 371 5XAH_C Importin-4; Histone, Ch 83.5 0.071 8.2E-06 50.5 0.0 142 561-715 163-307 (416) 372 5FRS_A SISTER CHROMATID COHESI 83.5 0.08 8.3E-06 57.5 0.0 149 548-715 282-431 (703) 373 4HM9_A Beta-catenin-like prote 83.5 0.087 8.3E-06 56.8 0.0 136 246-381 198-350 (568) 374 5FRP_A SISTER CHROMATID COHESI 83.4 0.082 8.4E-06 57.5 0.0 149 548-715 282-431 (703) 375 5GM6_G Prp8, Brr2, Snu114, Rse 83.4 0.077 8.4E-06 58.7 0.0 69 248-316 603-671 (971) 376 5ZWM_1 Pre-mRNA-splicing facto 83.4 0.077 8.4E-06 58.7 0.0 69 248-316 603-671 (971) 377 3TJZ_B ADP-ribosylation factor 83.4 0.075 8.5E-06 50.1 0.0 102 596-712 251-352 (355) 378 6CRI_R Bone marrow stromal ant 83.3 0.075 8.6E-06 53.5 0.0 101 246-359 100-200 (585) 379 6U62_A Regulatory-associated p 83.0 0.095 9E-06 62.5 0.0 159 544-715 468-630 (1392) 380 6BCX_W mTOR, Target of rapamyc 82.8 0.098 9.3E-06 62.1 0.0 159 544-715 476-638 (1343) 381 4QMH_A LP04448p; PROTEIN BINDI 82.8 0.081 9.4E-06 46.0 0.0 114 595-716 17-130 (241) 382 6QH5_A AP-2 complex subunit al 82.8 0.083 9.4E-06 54.0 0.0 140 548-713 75-216 (621) 383 6EMK_C Serine/threonine-protei 82.8 0.086 9.4E-06 64.9 0.0 71 548-625 922-993 (2474) 384 5MU7_A Coatomer subunit beta, 82.7 0.082 9.5E-06 49.3 0.0 71 548-624 39-110 (373) 385 6CRI_I Bone marrow stromal ant 82.7 0.081 9.6E-06 52.1 0.0 145 548-713 109-255 (570) 386 4QMI_B Cytoskeleton-associated 82.6 0.084 9.7E-06 46.0 0.0 112 595-715 19-131 (240) 387 4QMJ_A Cytoskeleton-associated 82.6 0.084 9.7E-06 46.0 0.0 112 595-715 19-131 (240) 388 6MZG_E Tubulin alpha-1A chain, 82.5 0.084 9.8E-06 52.4 0.0 147 549-715 315-466 (554) 389 1B3U_A PROTEIN PHOSPHATASE PP2 82.3 0.085 1E-05 51.8 0.0 147 547-713 164-310 (588) 390 2OF3_A ZYG-9; Multifunctional 82.0 0.098 1.1E-05 48.1 0.0 150 548-714 88-237 (266) 391 4I5L_D PP2A A alpha subunit (9 81.8 0.092 1.1E-05 51.5 0.0 147 547-713 160-306 (584) 392 4Y5J_A Mini spindles TOG3; XMA 81.7 0.097 1.1E-05 46.2 0.0 71 548-625 15-89 (248) 393 4P6Z_G BST2/tetherin, HIV-1 Vp 81.6 0.1 1.1E-05 53.7 0.0 137 549-713 81-217 (627) 394 5KC2_B Phosphatidylinositol 3- 81.5 0.11 1.2E-05 61.5 0.0 126 247-379 621-746 (1454) 395 6MZG_E Tubulin alpha-1A chain, 81.1 0.1 1.2E-05 51.7 0.0 151 550-714 57-211 (554) 396 6MZE_Z Tubulin alpha-1A chain, 81.1 0.1 1.2E-05 51.2 0.0 108 600-714 300-412 (536) 397 6RXU_UJ Periodic tryptophan pr 80.9 0.12 1.2E-05 62.5 0.0 152 548-713 1625-1791(1802) 398 5FVM_B SERINE/THREONINE-PROTEI 80.8 0.12 1.3E-05 63.5 0.0 147 548-714 1008-1155(2471) 399 6GWC_C Tubulin alpha chain, Tu 80.7 0.11 1.3E-05 45.3 0.0 49 654-714 120-168 (232) 400 1OYZ_A X-RAY STRUCTURE OF YB61 80.6 0.11 1.3E-05 46.1 0.0 64 549-623 92-156 (280) 401 6GX7_F Tubulin alpha chain, Tu 80.5 0.12 1.3E-05 44.1 0.0 122 548-713 46-167 (201) 402 2NYL_A Protein phosphatase 2, 80.4 0.11 1.3E-05 50.7 0.0 147 547-713 158-304 (582) 403 5VJC_B Protein mini spindles; 80.3 0.12 1.4E-05 47.2 0.0 72 547-625 50-121 (271) 404 6RXV_UJ Periodic tryptophan pr 80.3 0.13 1.4E-05 62.1 0.0 152 548-713 1625-1791(1802) 405 4I5L_D PP2A A alpha subunit (9 80.2 0.11 1.4E-05 50.8 0.0 109 547-670 238-349 (584) 406 1IBR_B RAN IMPORTIN BETA SUBU 80.2 0.12 1.4E-05 49.6 0.0 156 549-716 261-440 (462) 407 1B3U_A PROTEIN PHOSPHATASE PP2 80.1 0.12 1.4E-05 50.8 0.0 109 547-670 242-353 (588) 408 4P6Z_G BST2/tetherin, HIV-1 Vp 80.0 0.13 1.4E-05 52.9 0.0 67 548-625 152-218 (627) 409 5NR4_A CLIP-associating protei 80.0 0.12 1.4E-05 44.1 0.0 109 244-360 51-159 (230) 410 2P8Q_A Importin beta-1 subunit 79.9 0.12 1.4E-05 54.0 0.0 154 548-714 129-289 (876) 411 4I5L_D PP2A A alpha subunit (9 79.9 0.12 1.4E-05 50.6 0.0 147 547-713 320-466 (584) 412 1QGR_A IMPORTIN BETA SUBUNIT, 79.8 0.12 1.4E-05 54.2 0.0 154 548-714 129-289 (876) 413 1B3U_A PROTEIN PHOSPHATASE PP2 79.8 0.12 1.5E-05 50.6 0.0 146 547-712 324-469 (588) 414 6MZE_Z Tubulin alpha-1A chain, 79.7 0.13 1.5E-05 50.5 0.0 152 550-715 57-212 (536) 415 5F0N_A cohesin subunit Pds5, K 79.1 0.17 1.6E-05 59.2 0.0 150 547-714 271-420 (1175) 416 4NEE_G AP-2 complex subunit si 78.8 0.15 1.7E-05 48.9 0.0 115 548-671 149-273 (398) 417 3W3U_A Importin subunit beta-3 78.8 0.14 1.7E-05 55.2 0.0 158 548-714 849-1007(1078) 418 4NEE_B AP-2 complex subunit si 78.7 0.15 1.7E-05 49.0 0.0 115 548-671 149-273 (398) 419 3DAD_A FH1/FH2 domain-containi 78.5 0.18 1.7E-05 50.5 0.0 154 565-729 135-309 (339) 420 5VJC_A Protein mini spindles; 78.4 0.16 1.7E-05 46.5 0.0 73 546-625 49-121 (271) 421 5WBJ_A Regulatory-associated p 78.3 0.18 1.8E-05 59.3 0.0 156 548-716 467-631 (1287) 422 5WBK_A Regulatory-associated p 78.3 0.18 1.8E-05 59.3 0.0 156 548-716 467-631 (1287) 423 6EN4_C Splicing factor 3B subu 78.2 0.15 1.8E-05 53.3 0.0 154 548-715 192-347 (852) 424 5F0O_A cohesin subunit Pds5, K 78.2 0.18 1.8E-05 58.5 0.0 150 547-714 280-429 (1133) 425 2NYL_A Protein phosphatase 2, 77.8 0.16 1.9E-05 49.5 0.0 109 547-670 236-347 (582) 426 3W3W_A Importin subunit beta-3 77.6 0.16 1.9E-05 54.7 0.0 157 548-714 849-1007(1078) 427 4LAC_A Serine/threonine-protei 77.5 0.17 1.9E-05 44.2 0.0 115 239-360 27-141 (258) 428 6FT5_A A3_A3; alphaRep, artifi 77.5 0.17 1.9E-05 47.7 0.0 60 547-623 54-113 (409) 429 1F59_B IMPORTIN BETA-1/FXFG NU 77.4 0.17 2E-05 48.1 0.0 158 547-714 35-204 (442) 430 2NYL_A Protein phosphatase 2, 77.3 0.16 2E-05 49.4 0.0 70 547-625 318-387 (582) 431 5FVM_B SERINE/THREONINE-PROTEI 77.2 0.18 2E-05 61.6 0.0 71 548-625 925-996 (2471) 432 3LTJ_A AlphaRep-4; protein eng 77.2 0.18 2E-05 42.7 0.0 121 548-712 77-197 (201) 433 5JO8_A CEP104; centriolar prot 77.2 0.18 2E-05 46.5 0.0 155 548-714 87-245 (279) 434 4P6Z_G BST2/tetherin, HIV-1 Vp 77.2 0.18 2E-05 51.7 0.0 101 246-359 117-217 (627) 435 1GCJ_B IMPORTIN-BETA; HEAT REP 77.2 0.17 2E-05 48.4 0.0 154 549-714 267-444 (460) 436 6GWC_C Tubulin alpha chain, Tu 76.9 0.18 2.1E-05 43.9 0.0 121 548-712 108-228 (232) 437 3QML_D 78 kDa glucose-regulate 76.8 0.22 2.1E-05 49.4 0.0 104 609-717 42-154 (315) 438 4G3A_B CLIP-associating protei 76.8 0.18 2.1E-05 43.5 0.0 113 244-358 6-118 (237) 439 6IDX_A Engulfment and cell mot 76.8 0.22 2.1E-05 52.8 0.0 157 563-731 102-272 (524) 440 6IE1_A Engulfment and cell mot 76.8 0.22 2.1E-05 52.8 0.0 157 563-731 102-272 (524) 441 5H2V_A Importin subunit beta-3 76.6 0.18 2.1E-05 54.2 0.0 157 548-714 849-1007(1078) 442 1TE4_A conserved protein MTH18 76.5 0.19 2.2E-05 39.5 0.0 118 548-710 13-130 (131) 443 6S47_Bi 60S ribosomal protein 76.5 0.2 2.2E-05 54.8 0.0 155 548-714 127-321 (972) 444 1OYZ_A X-RAY STRUCTURE OF YB61 76.4 0.19 2.2E-05 44.5 0.0 96 596-712 91-187 (280) 445 5NR4_A CLIP-associating protei 76.2 0.19 2.2E-05 42.7 0.0 111 595-713 6-122 (230) 446 5A1V_E ADP-RIBOSYLATION FACTOR 75.9 0.22 2.3E-05 54.5 0.0 137 548-713 69-205 (874) 447 5NZR_G Coatomer subunit alpha, 75.9 0.22 2.3E-05 54.5 0.0 137 548-713 69-205 (874) 448 6HWP_A A3_bGFPD; alphaRep, art 75.5 0.21 2.4E-05 46.8 0.0 49 654-714 129-177 (409) 449 3W3U_A Importin subunit beta-3 75.5 0.21 2.4E-05 53.8 0.0 152 549-714 358-512 (1078) 450 4QMI_B Cytoskeleton-associated 75.5 0.21 2.4E-05 43.2 0.0 107 245-360 59-167 (240) 451 4QMJ_A Cytoskeleton-associated 75.5 0.21 2.4E-05 43.2 0.0 107 245-360 59-167 (240) 452 2IX8_A ELONGATION FACTOR 3A; N 75.4 0.22 2.4E-05 54.3 0.0 153 548-713 128-318 (976) 453 5XAH_A Importin-4; Histone, Ch 75.4 0.21 2.4E-05 46.9 0.0 162 548-713 33-222 (416) 454 5XAH_C Importin-4; Histone, Ch 75.4 0.21 2.4E-05 46.9 0.0 162 548-713 33-222 (416) 455 5H2V_A Importin subunit beta-3 75.1 0.22 2.5E-05 53.6 0.0 154 548-714 357-512 (1078) 456 6OWT_A AP-2 complex subunit al 75.0 0.24 2.6E-05 54.6 0.0 140 548-713 75-216 (939) 457 4G3A_B CLIP-associating protei 74.9 0.22 2.6E-05 42.9 0.0 107 548-671 91-198 (237) 458 4XL5_C Green fluorescent prote 74.6 0.23 2.7E-05 43.8 0.0 121 548-712 139-259 (263) 459 4FDD_A Transportin-1, RNA-bind 74.5 0.23 2.7E-05 51.3 0.0 155 548-714 129-286 (852) 460 4D4Z_A DEOXYHYPUSINE HYDROXYLA 74.4 0.23 2.7E-05 44.2 0.0 124 546-711 9-134 (294) 461 4D50_A DEOXYHYPUSINE HYDROXYLA 74.4 0.23 2.7E-05 44.2 0.0 124 546-711 9-134 (294) 462 6QH5_A AP-2 complex subunit al 74.2 0.24 2.8E-05 50.3 0.0 69 548-625 147-217 (621) 463 5LPH_B Centrosomal protein of 74.0 0.26 2.8E-05 45.9 0.0 155 549-714 94-251 (288) 464 1QBK_B STRUCTURE OF THE KARYOP 73.9 0.24 2.8E-05 51.6 0.0 156 548-715 129-287 (890) 465 3W3W_A Importin subunit beta-3 73.9 0.24 2.9E-05 53.2 0.0 153 548-714 357-512 (1078) 466 1IBR_B RAN IMPORTIN BETA SUBU 73.6 0.25 2.9E-05 47.1 0.0 158 547-714 35-204 (462) 467 5VCH_A Kap123; Bidding yeast k 73.4 0.26 3E-05 53.4 0.0 153 548-714 361-516 (1116) 468 6QH7_A AP-2 complex subunit al 73.4 0.26 3E-05 50.0 0.0 69 548-625 147-217 (621) 469 2JKT_A AP-2 COMPLEX SUBUNIT AL 73.3 0.27 3E-05 49.9 0.0 69 548-625 147-217 (623) 470 1GCJ_B IMPORTIN-BETA; HEAT REP 73.0 0.27 3.1E-05 47.0 0.0 158 547-714 41-210 (460) 471 1OYZ_A X-RAY STRUCTURE OF YB61 73.0 0.27 3.1E-05 43.4 0.0 121 547-710 159-279 (280) 472 2JKT_A AP-2 COMPLEX SUBUNIT AL 72.8 0.28 3.2E-05 49.7 0.0 67 548-623 330-397 (623) 473 5VE8_B Kap123, Histone H3; Bid 72.7 0.27 3.2E-05 53.1 0.0 153 548-714 361-516 (1116) 474 4ZV6_A AlphaRep-7, Octarellin 71.7 0.3 3.5E-05 43.7 0.0 29 685-714 140-168 (294) 475 6BZX_A alpha-Rep, Octarellin V 71.4 0.31 3.6E-05 43.6 0.0 29 685-714 140-168 (294) 476 5IFE_C Splicing factor 3B subu 70.4 0.38 3.9E-05 55.8 0.0 154 548-715 644-799 (1304) 477 6AHD_1 Pre-mRNA-processing-spl 70.4 0.38 3.9E-05 55.8 0.0 154 548-715 644-799 (1304) 478 2QK2_A LP04448p; Mini spindles 70.3 0.34 4E-05 41.6 0.0 113 243-358 13-126 (242) 479 6MZG_E Tubulin alpha-1A chain, 70.0 0.35 4.1E-05 47.5 0.0 71 549-625 138-211 (554) 480 6QH7_A AP-2 complex subunit al 69.9 0.36 4.1E-05 48.9 0.0 100 247-359 76-177 (621) 481 1UKL_A Importin beta-1 subunit 69.9 0.35 4.1E-05 50.3 0.0 154 548-714 129-289 (876) 482 6EMK_C Serine/threonine-protei 69.9 0.38 4.1E-05 58.8 0.0 136 562-714 1016-1152(2474) 483 4XL5_C Green fluorescent prote 69.9 0.36 4.1E-05 42.4 0.0 49 654-714 120-168 (263) 484 4D4Z_A DEOXYHYPUSINE HYDROXYLA 69.8 0.36 4.1E-05 42.9 0.0 127 547-715 161-289 (294) 485 4D50_A DEOXYHYPUSINE HYDROXYLA 69.8 0.36 4.1E-05 42.9 0.0 127 547-715 161-289 (294) 486 6QH5_A AP-2 complex subunit al 69.7 0.37 4.2E-05 48.8 0.0 67 548-623 330-397 (621) 487 4XL5_C Green fluorescent prote 69.5 0.37 4.2E-05 42.3 0.0 88 600-714 143-230 (263) 488 6LTJ_L Histone H3.2, Histone H 69.2 0.52 4.4E-05 55.1 0.0 106 609-716 1064-1189(1295) 489 5WLC_LM rpS18_uS13, rpS4_eS4, 69.1 0.44 4.4E-05 57.4 0.0 153 548-713 1597-1758(1769) 490 5YVI_A Transportin-1, RNA-bind 69.1 0.37 4.4E-05 49.7 0.0 155 548-714 131-288 (868) 491 3VWA_A Cytoplasmic export prot 68.9 0.42 4.5E-05 49.3 0.0 111 594-715 340-450 (560) 492 3VWA_B Cytoplasmic export prot 68.9 0.42 4.5E-05 49.2 0.0 111 594-715 340-450 (560) 493 3C5W_A PP2A A subunit, PP2A C; 68.8 0.38 4.5E-05 40.3 0.0 109 245-360 7-115 (232) 494 4K92_B CLIP-associating protei 68.6 0.41 4.6E-05 43.1 0.0 109 244-360 129-237 (273) 495 6MQ7_B CLIP-associating protei 68.6 0.41 4.6E-05 43.1 0.0 109 244-360 129-237 (273) 496 4LAC_A Serine/threonine-protei 68.3 0.41 4.7E-05 41.4 0.0 109 245-360 111-219 (258) 497 6MQ5_A CLIP-associating protei 68.0 0.43 4.8E-05 42.3 0.0 108 245-360 49-157 (257) 498 2QK1_A Protein STU2; stu2, Stu 67.9 0.42 4.9E-05 40.9 0.0 116 244-360 103-221 (249) 499 4D4Z_A DEOXYHYPUSINE HYDROXYLA 67.6 0.43 5E-05 42.3 0.0 60 547-623 74-135 (294) 500 4D50_A DEOXYHYPUSINE HYDROXYLA 67.6 0.43 5E-05 42.3 0.0 60 547-623 74-135 (294) No 1 >1XM9_A plakophilin 1 Plakophilin-1; armadillo repeat, CELL ADHESION; 2.8A {Homo sapiens} SCOP: a.118.1.24 Probab=99.69 E-value=6.3e-22 Score=206.93 Aligned_cols=453 Identities=100% Similarity=1.422 Sum_probs=304.9 Template_Neff=12.600 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) .++.+..++.+.++.++..++.+|..++...+.....+...++++.+..++.+.+..++..++.++.+++.........+ T Consensus 3 ~l~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~ 82 (457) T 1XM9_A 3 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 82 (457) T ss_dssp CHHHHHHHHHSSCTHHHHHHHHHHHHHTSSCSSHHHHHHHTTHHHHHHHHTTSSCHHHHHHHHHHHHHHHSSCHHHHHHH T ss_pred cHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCHHHHHHHHhcCCCHHHHHHHHHHHHHHhhCCHHHHHHH Confidence 45566777777778889999999999885444444445555778888888888788899999999999886544333444 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFN 405 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~ 405 (747) ...+.++.++.++....+..++..++.+|.+++........+..++++.|+.++..+.++|+.+.+.+.....++++... T Consensus 83 ~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~ 162 (457) T 1XM9_A 83 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFN 162 (457) T ss_dssp HHTTCHHHHHHHHTTCCCHHHHHHHHHHHHHHHTSSSTHHHHHHHHHHHCCCCCCHHHHTCC---------CCCHHHHHH T ss_pred HhcChHHHHHHHhhhCCCHHHHHHHHHHHHHHhCCHHHHHHHHcchHHHHHHHhccccCCCCCCCCCcccccCCHHHHHH Confidence 44567777777775344677888899999999875444333335788999999999999999988887777777777766 Q NP_000290.2 406 ATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYR 485 (747) Q Consensus 406 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 485 (747) +..+|.. +...+..++.+....|+++.|+.+++.+......+..-.+.+..+|.|++.. T Consensus 163 a~~~L~~---------------------l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~l~~l~~~ 221 (457) T 1XM9_A 163 ATGCLRN---------------------LSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYR 221 (457) T ss_dssp HHHHHHH---------------------HTTSHHHHHHHTTSTTHHHHHHHHHHHHHHHTCTTCTTHHHHHHHHHHHTTT T ss_pred HHHHHHH---------------------HccChHHHHHHHhcccHHHHHHHHHHHhhhcCcCCHHHHHHHHHHHHHHhcc Confidence 6665543 2222223444555567788888887765555556777888999999999999 Q NP_000290.2 486 LDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATL 565 (747) Q Consensus 486 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eVr 565 (747) .+.+.+..+..+++.++..+..+...+|+.+...+++....+|.++....+......+.+.++++.++.++....+..++ T Consensus 222 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~ 301 (457) T 1XM9_A 222 LDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATL 301 (457) T ss_dssp HHHHSCCHHHHHHHTC----------------------------CCCCCSSCCGGGGGGSHHHHHHHHHHHHHCCCHHHH T ss_pred cccCCCcchhhhhhcccccccccccccccCcccchhccccccCCCCcccCCCchhHHhhchhHHHHHHHHhccCCCHHHH Confidence 99999999999999999999999999999999999999999999998888888888888999999999999733556777 Q NP_000290.2 566 EACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLT 645 (747) Q Consensus 566 ~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~ 645 (747) ..++.+|.+++..............+...++++.|+.++.+.++.++..++.+|.+++..+.....+..++++.++.++. T Consensus 302 ~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~l~~~l~ 381 (457) T 1XM9_A 302 EACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLT 381 (457) T ss_dssp HHHHHHHHHHTTCSSSHHHHHHHCCCCCSCCHHHHHHHTTCSCHHHHHHHHHHHHHHHTSGGGHHHHHHHTHHHHHHTTT T ss_pred HHHHHHHHHHHhccccccCCcchhhhhhcchHHHHHHHHhcCCHHHHHHHHHHHHHHhcCHHHHHHHHcccHHHHHHHHh Confidence 78999999998753200000002233456788999999988888999999999999996644432233347777777776 Q NP_000290.2 646 SHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQG 719 (747) Q Consensus 646 s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~~~~ 719 (747) ........++.++..++.+|.+|+...+.....+.+.++++.|..++....++.++..++.+|.+++.+.+.+. T Consensus 382 ~~~~~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~ll~~~~~~~v~~~a~~~L~~l~~~~~~~~ 455 (457) T 1XM9_A 382 SHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQG 455 (457) T ss_dssp SCCSCSTTHHHHHHHHHHHHHHHHTTCTHHHHHHCCHHHHHHHHHHHHCTTCHHHHHHHHHHHHTTSSSTTCSS T ss_pred cCCCCCCCCHHHHHHHHHHHHHHHhcCHHHHHHHHhccHHHHHHHHHhCCCCHHHHHHHHHHHHHHhhcHhHhc Confidence 52000000567888999999999865566666777778889999988862278899999999999998877654 No 2 >3L6X_A Catenin delta-1, E-cadherin; p120, catenin, cadherin, E-cadherin, armadillo; HET: SO4; 2.4A {Homo sapiens} Probab=99.41 E-value=1.1e-17 Score=185.51 Aligned_cols=438 Identities=32% Similarity=0.540 Sum_probs=299.3 Template_Neff=11.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFR-STTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~-~~~~~~ 323 (747) ..++.++.++...++.++..++.+|.+++.........+...++++.|+.++.+.+..++..++.+|.+++.. ...... T Consensus 48 ~~l~~li~~L~~~~~~v~~~a~~~L~~L~~~~~~~~~~~~~~g~i~~Lv~lL~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 127 (584) T 3L6X_A 48 PELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKI 127 (584) T ss_dssp CCHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHGGGCSSHHHHHHHHHHHHHHTSSSCHHHHH T ss_pred CcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCChHHHHHHHHCCcHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCCHHHHH Confidence 4566677777777788899999999998854444444455567888888888887788999999999999864 333444 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMS--REVVDPE 401 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL~~~~~~~~~~~~~~~--~~~~~~~ 401 (747) .+...+.++.++.++....+..++..++.+|.+++........++..++..|+.++..+.++|........ ....+++ T Consensus 128 ~~~~~~~i~~L~~ll~~~~~~~v~~~a~~~L~~L~~~~~~~~~l~~~~l~~L~~~l~~~~~~~~~~~~~~~~~~~~~~~~ 207 (584) T 3L6X_A 128 AIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWES 207 (584) T ss_dssp HHHHTTHHHHHHHHHHHCCSHHHHHHHHHHHHHHTTSGGGHHHHHHHTHHHCCCCCCHHHHCCC----------CCCCHH T ss_pred HHHcCChHHHHHHHHHHcCCHHHHHHHHHHHHHHhcCHHHHHHHHHHHHHHHHHhccccCCCCCCCCCcCCCCcccChHH Confidence 44555778888888863346678889999999998765544444445778888888888877754332211 1223455 Q NP_000290.2 402 VFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSAD-AGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLH 480 (747) Q Consensus 402 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 480 (747) +..++.++|+. ++..+ ..++.++...|+++.|+..++.++....-+.+.+++|.++|. T Consensus 208 v~~~a~~~L~~---------------------l~~~~~~~~~~l~~~~g~v~~L~~~l~~~~~~~~~~~~~~~~a~~~L~ 266 (584) T 3L6X_A 208 VLTNTAGCLRN---------------------VSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLR 266 (584) T ss_dssp HHHHHHHHHHH---------------------HTSSCHHHHHHHHHSTTHHHHHHHHHHHHHHTTCCSCHHHHHHHHHHH T ss_pred HHHHHHHHHHH---------------------HhcCCHHHHHHHHhCCCHHHHHHHHHHHHhcCCCCChHHHHHHHHHHH Confidence 66666665543 22222 245556666789999999888765544557788999999999 Q NP_000290.2 481 NLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSK 560 (747) Q Consensus 481 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~ 560 (747) ||++..+.++|...+..+.... ..+ +-...+......+.+.++++.|+.++.... T Consensus 267 ~L~~~~~~~~~~~~~~~~~~~~-----------~~~--------------~~~~~~~~~~~~l~~~~~~~~l~~ll~~~~ 321 (584) T 3L6X_A 267 NLSYQVHREIPQAERYQEAAPN-----------VAN--------------NTGTSPARGYELLFQPEVVRIYISLLKESK 321 (584) T ss_dssp HHHTTHHHHSTTCCC---------------------------------------CCCCGGGGGGSHHHHHHHHHHHHHCC T ss_pred HHHhhhhccChhHHHHHHhcCc-----------CCC--------------CCCCCChhhhhHhhChhHHHHHHHHHHcCC Confidence 9999998888765554432110 000 111222233344567889999999998423 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEV 640 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~L 640 (747) ++.++..++.+|.+++......... ....+.+.++++.|+.++.+.++.++..++++|.+|+........+..++++.| T Consensus 322 ~~~~~~~a~~~L~~L~~~~~~~~~~-~~~~~~~~~~l~~L~~ll~~~~~~v~~~a~~~L~~L~~~~~~~~~l~~~~l~~L 400 (584) T 3L6X_A 322 TPAILEASAGAIQNLCAGRWTYGRY-IRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKELIGKHAIPNL 400 (584) T ss_dssp CHHHHHHHHHHHHHHHSSCSHHHHH-HHHHHTSHHHHHHHHHGGGCSCHHHHHHHHHHHHHHHTTCSCHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHhCCCccCCHH-HHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHhcChHHHHHHHcchHHHH Confidence 7788899999999998742100000 233445678899999999988889999999999999877444333334677888 Q NP_000290.2 641 TRLLTSHTGNT--SNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSS-ASPKAAEAARLLLSDMWSSKEL 717 (747) Q Consensus 641 l~LL~s~s~~~--~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~-~d~eVr~aAL~aLsnL~~~~~~ 717 (747) +.++....... ..+..++..++.+|.+++...+.....+.+.++++.|+.++... .+..++..|+.+|.+++...+. T Consensus 401 ~~~L~~~~~~~~~~~~~~~~~~~l~~L~~l~~~~~~~~~~l~~~~~l~~L~~ll~~~~~~~~v~~~a~~~L~~l~~~~~~ 480 (584) T 3L6X_A 401 VKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKEL 480 (584) T ss_dssp HHTSSSSSCSGGGTCCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHTCSSSCHHHHHHHHHHHHHHHTSHHH T ss_pred HHcCCCCCCCCCcCCCHHHHHHHHHHHHHHHhcCHHHHHHHHHCCHHHHHHHHHhcCCCCHHHHHHHHHHHHHHhCCHHH Confidence 88776521000 00344577889999998876666777777888899999988653 1478899999999999999999 Q NP_000290.2 718 QGVLRQQGFDRN 729 (747) Q Consensus 718 ~~~~~~~~~~~~ 729 (747) ...+.+.|+-.. T Consensus 481 ~~~l~~~g~~~~ 492 (584) T 3L6X_A 481 RKPLEKEGWKKS 492 (584) T ss_dssp HHHHHTTTCCGG T ss_pred HHHHHHcCCchh Confidence 999998888766 No 3 >5D5K_C Importin subunit alpha-1, Poly [ADP-ribose]; PARP-2 NLS, PARP-2, poly(ADP-ribose)polymerase-2, Importin; 1.9A {Mus musculus} Probab=98.56 E-value=1.1e-11 Score=126.19 Aligned_cols=369 Identities=14% Similarity=0.172 Sum_probs=230.1 Template_Neff=13.100 Q NP_000290.2 243 SGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESA-KQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTT 320 (747) Q Consensus 243 ~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~-~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~ 320 (747) ....++.+...+.+.++.++..++.++..+....... ...+...++++.++..+. ..++.++..++.++..++..... T Consensus 11 ~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~ 90 (466) T 5D5K_C 11 VNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSE 90 (466) T ss_dssp CSCCHHHHHHHHTSSCHHHHHHHHHHHHHHHTCSSCCCHHHHHHTTHHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHH T ss_pred cCcCHHHHHHHHccCCHHHHHHHHHHHHHHHhcCCCCCHHHHHHcCcHHHHHHHhhCCCChHHHHHHHHHHHHHcCCChH Confidence 4456667777777778888999999998887643221 122333456777777776 34567888899999888764443 Q NP_000290.2 321 NKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVV 398 (747) Q Consensus 321 ~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~ 398 (747) ....+...++++.+...+. ..++.++..++.++..++..... ...+.. ++++.+..++..+. .+.. T Consensus 91 ~~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~-----------~~~~ 158 (466) T 5D5K_C 91 QTKAVVDGGAIPAFISLLA-SPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPD-----------LSTL 158 (466) T ss_dssp HHHHHHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHTTCSSC-----------GGGS T ss_pred HHHHHhccchHHHHHHHhc-CCCCcHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhhCCC-----------cccc Confidence 3333444457777888876 56778888999999998875432 222333 67777777776421 1112 Q NP_000290.2 399 DPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCV 478 (747) Q Consensus 399 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 478 (747) ++++...+..++..-. .............+++..+...++. -+..-...+... T Consensus 159 ~~~~~~~a~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~ 211 (466) T 5D5K_C 159 ACGYLRNLTWTLSNLC---------------------RNKNPAPPLDAVEQILPTLVRLLHH------NDPEVLADSCWA 211 (466) T ss_dssp CHHHHHHHHHHHHHHS---------------------CCCSSCCCHHHHHHHHHHHHHHTTS------SCHHHHHHHHHH T ss_pred cHHHHHHHHHHHHHHH---------------------cCCCCCCChHHHHHHHHHHHHHHcC------CCHHHHHHHHHH Confidence 3334444433332211 1011111111123444444443321 112222223333 Q NP_000290.2 479 LHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK 558 (747) Q Consensus 479 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s 558 (747) |.++...- ......+.+.++++.++.++. T Consensus 212 l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~- 240 (466) T 5D5K_C 212 ISYLTDGP--------------------------------------------------NERIEMVVKKGVVPQLVKLLG- 240 (466) T ss_dssp HHHHTSSC--------------------------------------------------HHHHHHHHTTTCHHHHHHHHT- T ss_pred HHHHhcCC--------------------------------------------------chHHHHHHHCChHHHHHHHhc- Confidence 33332110 001111234567888888887 Q NP_000290.2 559 SKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQV 636 (747) Q Consensus 559 s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~gi 636 (747) +.++.++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++.. +.. ..+...++ T Consensus 241 ~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~ 315 (466) T 5D5K_C 241 ATELPIVTPALRAIGNIVTGTDE-----QTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGL 315 (466) T ss_dssp CSCHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTGGGGHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTC T ss_pred CCCchHHHHHHHHHHHHhcCCHH-----HHHHHHccChhHhHHHHhhCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCH Confidence 46778888999999999875332 233334567888999999888889999999999999876 322 23344567 Q NP_000290.2 637 FPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS-QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 637 I~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~-s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) ++.+..++.+ .++.++..++.+|.+++.. .......+.+.++++.+..++.+. ++.++..++.+|.+++. T Consensus 316 ~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~l~~l~~ 386 (466) T 5D5K_C 316 VPFLVGVLSK------ADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAK-DTKIIQVILDAISNIFQ 386 (466) T ss_dssp HHHHHHHHHS------SCHHHHHHHHHHHHHHHHHSCHHHHHHHHHTTCHHHHHHGGGCS-CHHHHHHHHHHHHHHHH T ss_pred HHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCCHHHHHHHHhCCcHHHHHHHhhcC-CHHHHHHHHHHHHHHHH Confidence 8888888876 3678889999999999874 233344455556788888888866 78899999999999987 No 4 >3NMZ_A APC variant protein, Rho guanine; protein-protein complex, armadillo repeats, CELL; 3.01A {Homo sapiens} Probab=98.55 E-value=1.3e-11 Score=128.97 Aligned_cols=381 Identities=18% Similarity=0.200 Sum_probs=233.7 Template_Neff=12.000 Q NP_000290.2 238 EDIECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQN------------VQQ 305 (747) Q Consensus 238 ~~~~~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~e------------Vr~ 305 (747) .+..+...+++.++.++...+... ++.+|..++.. ......+...+.++.+..++...+.. ++. T Consensus 25 ~~~~~~~~~i~~l~~~l~~~~~~~---a~~~L~~l~~~-~~~~~~~~~~g~i~~L~~ll~~~~~~~~~~~~~~~~~~v~~ 100 (458) T 3NMZ_A 25 SHLGTKVEMVYSLLSMLGTHDKDD---MSRTLLAMSSS-QDSCISMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARA 100 (458) T ss_pred HHhHhccchHHHHHHHhCCCCHHH---HHHHHHHHhCC-chHHHHHHHcCcHHHHHHHhcCCChhhcCCCCcccCHHHHH Confidence 344445556677777776554443 77778777643 23333444556778888888765555 888 Q NP_000290.2 306 AAAGALRNLVFRST---TNKLETRRQNGIREAVSLLR--------------------RTGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 306 ~AL~aLs~La~~~~---~~~~~ll~~~IL~~Ll~lL~--------------------ss~d~eVr~~AL~aLsnLas~~~ 362 (747) .++.+|.+++...+ .....+...+.++.+...+. ...+..++..++.++.+++.... T Consensus 101 ~a~~~L~~l~~~~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~a~~~L~~l~~~~~ 180 (458) T 3NMZ_A 101 RASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEE 180 (458) T ss_pred HHHHHHHHHHcCCCCCHHHHHHHHHCCcHHHHHHHHHhhhhcccchhhHHHHHHhcCCCChHHHHHHHHHHHHHHcCChH Confidence 99999999885432 22222222334444444421 01234455667778887776554 Q NP_000290.2 363 LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSA-DAG 440 (747) Q Consensus 363 ~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~ 440 (747) ....+.. ++++.|+.++....... .... ...++++...+..+|.. +... +.. T Consensus 181 ~~~~~~~~~~~~~l~~~l~~~~~~~----~~~~-~~~~~~~~~~a~~~L~~---------------------l~~~~~~~ 234 (458) T 3NMZ_A 181 HRHAMNELGGLQAIAELLQVDCEMY----GLTN-DHYSITLRRYAGMALTN---------------------LTFGDVAN 234 (458) T ss_pred HHHHHHHCChHHHHHHHHhccccCC----CCCC-CCCCHHHHHHHHHHHHH---------------------HHcCCHHH Confidence 4444444 77888888877532211 1110 11244554444444432 1111 111 Q NP_000290.2 441 RQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDK 520 (747) Q Consensus 441 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 520 (747) ++.+....|+++.|...++. .+..-.+.+..+|.|++..-+. T Consensus 235 ~~~~~~~~~~i~~l~~~l~~------~~~~~~~~a~~~L~~l~~~~~~-------------------------------- 276 (458) T 3NMZ_A 235 KATLCSMKGCMRALVAQLKS------ESEDLQQVIASVLRNLSWRADV-------------------------------- 276 (458) T ss_pred HHHHHHhCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHHCCCCh-------------------------------- Confidence 22233445667777666542 2334445555566665431100 Q NP_000290.2 521 MMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLK-EKGLPQ 599 (747) Q Consensus 521 ~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie-~giI~~ 599 (747) .....+.+.++++.|+.++....+..++..++++|.+++...+. ....+.. .++++. T Consensus 277 -----------------~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~~ 334 (458) T 3NMZ_A 277 -----------------NSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTE-----NKADICAVDGALAF 334 (458) T ss_pred -----------------hHHHHHHHCCHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCch-----hHHHHHHhcChHHH Confidence 01122356678888888887325667888999999999874332 2233344 778888 Q NP_000290.2 600 IARLLQS----GNSDVVRSGASLLSNMSR---H-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 600 Ll~LL~s----~d~eVr~~AL~aLsnLa~---~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) |+.++.. .+..++..++.+|.+++. . ... ..+...++++.|+.++.. .++.++..++++|.+++. T Consensus 335 l~~~l~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~l~~~~~~~~l~~~l~~------~~~~v~~~a~~~L~~l~~ 408 (458) T 3NMZ_A 335 LVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKS------HSLTIVSNACGTLWNLSA 408 (458) T ss_pred HHHHHcCCCCCCCHHHHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhCC------CCHHHHHHHHHHHHHHHC Confidence 8888872 346778889999988863 2 222 233456788888888876 367889999999999998 Q NP_000290.2 671 SQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 671 ~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ..+.....+.+.++++.|..++.+. ++.++..++.+|.+++... T Consensus 409 ~~~~~~~~l~~~~~~~~L~~ll~~~-~~~v~~~a~~~L~~l~~~~ 452 (458) T 3NMZ_A 409 RNPKDQEALWDMGAVSMLKNLIHSK-HKMIAMGSAAALRNLMANR 452 (458) T ss_pred CCHHHHHHHHHCCcHHHHHHHHhCC-CHHHHHHHHHHHHHHHcCC Confidence 5566677777778899999988876 6778999999999998654 No 5 >4UAF_B Importin alpha 1 import receptor; importin karyopherin complex NLS, PROTEIN; HET: PO4; 1.698A {Mus musculus} Probab=98.54 E-value=1.3e-11 Score=125.71 Aligned_cols=369 Identities=14% Similarity=0.172 Sum_probs=229.2 Template_Neff=13.100 Q NP_000290.2 243 SGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESA-KQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTT 320 (747) Q Consensus 243 ~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~-~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~ 320 (747) ....++.+...+.+.++.++..++.++..+....... ...+...++++.++..+. ..++.++..++.++..++..... T Consensus 11 ~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~ 90 (466) T 4UAF_B 11 VNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSE 90 (466) T ss_pred cCcCHHHHHHHHccCCHHHHHHHHHHHHHHHhcCCCCCHHHHHHcCcHHHHHHHhhCCCChHHHHHHHHHHHHHhcCChH Confidence 4456667777777778888999999998887643221 122333456777777776 34567888899999888764443 Q NP_000290.2 321 NKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVV 398 (747) Q Consensus 321 ~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~ 398 (747) ....+...++++.+...+. ..++.++..++.++..++..... ...+.. ++++.+..++..+. .+.. T Consensus 91 ~~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~-----------~~~~ 158 (466) T 4UAF_B 91 QTKAVVDGGAIPAFISLLA-SPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPD-----------LSTL 158 (466) T ss_pred HHHHHHccChHHHHHHHhc-CCCCCHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhhCCC-----------cccc Confidence 3333444457777888876 56778888999999998875432 222233 67777777775421 1112 Q NP_000290.2 399 DPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCV 478 (747) Q Consensus 399 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 478 (747) ++++...+..++..-. .............+++..+...+.. -+..-...+... T Consensus 159 ~~~~~~~~~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~ 211 (466) T 4UAF_B 159 ACGYLRNLTWTLSNLC---------------------RNKNPAPPLDAVEQILPTLVRLLHH------NDPEVLADSCWA 211 (466) T ss_pred cHHHHHHHHHHHHHHH---------------------cCCCCCCChhHHHHHHHHHHHHHcC------CCHHHHHHHHHH Confidence 3334333333332211 0001111111113344444433321 111222222333 Q NP_000290.2 479 LHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK 558 (747) Q Consensus 479 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s 558 (747) |.++...- ......+.+.++++.++.++. T Consensus 212 l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~- 240 (466) T 4UAF_B 212 ISYLTDGP--------------------------------------------------NERIEMVVKKGVVPQLVKLLG- 240 (466) T ss_pred HHHHhcCC--------------------------------------------------cHHHHHHHHCChHHHHHHHhc- Confidence 33332110 001112245567888888887 Q NP_000290.2 559 SKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQV 636 (747) Q Consensus 559 s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~gi 636 (747) +.++.++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++.. +.. ..+...++ T Consensus 241 ~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~ 315 (466) T 4UAF_B 241 ATELPIVTPALRAIGNIVTGTDE-----QTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGL 315 (466) T ss_pred CCChhHHHHHHHHHHHHhcCCHH-----HHHHHhccCHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCH Confidence 46778888999999999875332 233334567888899999888889999999999999876 322 23344567 Q NP_000290.2 637 FPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS-QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 637 I~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~-s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) ++.+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.+|.+++. T Consensus 316 ~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~l~~l~~ 386 (466) T 4UAF_B 316 VPFLVGVLSK------ADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAK-DTKIIQVILDAISNIFQ 386 (466) T ss_pred HHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCCHHHHHHHHhCCcHHHHHHHhhcC-CHHHHHHHHHHHHHHHH Confidence 8888888876 3678889999999999874 233344455556788888888876 78899999999999987 No 6 >4U5L_A deltaIBB-importin-alpha1; TPX2, inhibitor, TRANSPORT PROTEIN; HET: 3D6; 2.53A {Mus musculus} Probab=98.52 E-value=1.7e-11 Score=122.96 Aligned_cols=360 Identities=16% Similarity=0.184 Sum_probs=217.1 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+. ..++.++..++.++..++...+.....+...++++.+...+.+.++.++..++.++..++......... T Consensus 49 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 128 (426) T 4U5L_A 49 LIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDL 128 (426) T ss_dssp CHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHHTCHHHHHH T ss_pred cHHHHHHHhccCCChHHHHHHHHHHHHHhCCCHHHHHHHHhcCcHHHHHHHhcCCChHHHHHHHHHHHHHhcCCHHHHHH Confidence 4555666665 445678888899998887654433334444567778888888778888999999999988654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAE-----IQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~e-----Vr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) +...++++.+...+. ..... ++..++.++..++.......... .++++.+..++.. T Consensus 129 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~---------------- 191 (426) T 4U5L_A 129 VIKHGAIDPLLALLA-VPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHH---------------- 191 (426) T ss_dssp HHHTTCHHHHHHTTC-SSCGGGSCHHHHHHHHHHHHHHTCCCSSCCCHHHHHHHHHHHHHHTTS---------------- T ss_pred HHHCCcHHHHHHHhh-CCCCchhhHHHHHHHHHHHHHHHcCCCCCCCccHHHHHHHHHHHHHhC---------------- Confidence 334456677777765 32222 67778888888776433222221 2555666665542 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) .|+++...+..++..-.... + .....+. -.+++..|...+.. .+..-...+.. T Consensus 192 ~~~~~~~~a~~~l~~l~~~~------~--------------~~~~~~~-~~~~~~~l~~~l~~------~~~~~~~~a~~ 244 (426) T 4U5L_A 192 NDPEVLADSCWAISYLTDGP------N--------------ERIEMVV-KKGVVPQLVKLLGA------TELPIVTPALR 244 (426) T ss_dssp SCHHHHHHHHHHHHHHTSSC------H--------------HHHHHHH-TTTCHHHHHHHHTC------SCHHHHHHHHH T ss_pred CCHHHHHHHHHHHHHHhhCC------c--------------HHHHHHh-hcChHHHHHHHhcC------CCccHHHHHHH Confidence 13444444444443211100 0 0000000 12233333333221 11122222333 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) .|.++...- ......+.+.++++.+..++. T Consensus 245 ~l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~ 274 (426) T 4U5L_A 245 AIGNIVTGT--------------------------------------------------DEQTQKVIDAGALAVFPSLLT 274 (426) T ss_dssp HHHHHTTSC--------------------------------------------------HHHHHHHHHTTGGGGHHHHTT T ss_pred HHHHHhcCC--------------------------------------------------HHHHHHHhccchHHHHHHHhc Confidence 333332100 001112245567888888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGN 634 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~ 634 (747) +.++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. . .. ..+... T Consensus 275 -~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~ 348 (426) T 4U5L_A 275 -NPKTNIQKEATWTMSNITAGRQD-----QIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHC 348 (426) T ss_dssp -CSSHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTCHHHHHHHHHSSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHT T ss_pred -CCChHHHHHHHHHHHHHhcCCHH-----HHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHHHHhC Confidence 46778888999999999875332 233334557888899998888888999999999999875 2 22 233445 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS------QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~------s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ++++.+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.++ T Consensus 349 ~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~l~~ll~~~-~~~v~~~a~~~l 421 (426) T 4U5L_A 349 GIIEPLMNLLSA------KDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHE-NESVYKASLNLI 421 (426) T ss_dssp TCHHHHHHGGGS------CCHHHHHHHHHHHHHHHHHHHTTTCHHHHHHHHHHTTHHHHHHGGGGSS-CHHHHHHHHHHH T ss_pred CcHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHHHHhcCchHHHHHHHHcCHHHHHHHHHhCC-CHHHHHHHHHHH Confidence 678888888876 3678899999999999763 123333444556788888888776 788898888888 Q NP_000290.2 709 SDMW 712 (747) Q Consensus 709 snL~ 712 (747) .++. T Consensus 422 ~~~~ 425 (426) T 4U5L_A 422 EKYF 425 (426) T ss_dssp HHHC T ss_pred HHHc Confidence 7764 No 7 >6SA7_B DARPin-Armadillo fusion C8long83; protein fusion, DARPin, Armadillo, shared; 3.3A {synthetic construct} Probab=98.48 E-value=2.5e-11 Score=127.02 Aligned_cols=136 Identities=24% Similarity=0.253 Sum_probs=93.8 Template_Neff=12.500 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.++.++..++.+|..++.........+...++++.+...+.+.++.++..++.++..++........ T Consensus 172 ~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~ 251 (510) T 6SA7_B 172 KKILKDLVKKLSSPNENELQNALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQ 251 (510) T ss_dssp HHHHHHHHHHTTCSSHHHHHHHHHHHHHHHHTCHHHHHHHHHHTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHH T ss_pred HHHHHHHHHHhcCCChHHHHHHHHHHHHHhcCChHHHHHHHHcCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHH Confidence 45666777777777788889999999998765544444444556788888888887888999999999998765443333 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) .+...++++.+...+. +.++.++..++.++..++..... ...+.. ++++.|+.++. T Consensus 252 ~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 309 (510) T 6SA7_B 252 AVIDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLS 309 (510) T ss_dssp HHHHTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHHHcCcHHHHHHHcc-CCCHHHHHHHHHHHHHHhcCChHHHHHHHHcChHHHHHHHhc Confidence 3444567777777775 55677888888888888754322 222222 56666666664 No 8 >4RV1_D Engineered Protein OR497; STRUCTURAL GENOMICS, PSI-BIOLOGY, PROTEIN STRUCTURE; 2.573A {SYNTHETIC CONSTRUCT} Probab=98.47 E-value=2.7e-11 Score=120.80 Aligned_cols=362 Identities=20% Similarity=0.254 Sum_probs=220.3 Template_Neff=13.300 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETR 326 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll 326 (747) ++.+...+.+.++.++..++.++..+..............++++.+...+.+.++.++..++.++..++........... T Consensus 4 ~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~ 83 (420) T 4RV1_D 4 VEKLVKLLTSTDSETQKEAARDLAEIASGPASAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIV 83 (420) T ss_dssp HHHHHHHHHCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHTTSCSCSSSHHHHHHHHHHHTTSCHHHHHHHH T ss_pred HHHHHHHhcCCCHHHHHHHHHHHHHHhcCcHHHHHHHHHCCHHHHHHHHcCCCCHHHHHHHHHHHHHHhcCCHHHHHHHH Confidence 44556666677788888999999888765433333333446677777888777788899999999888765433323333 Q NP_000290.2 327 RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFF 404 (747) Q Consensus 327 ~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~ 404 (747) ..++++.+...+. +.++.++..++.++..+..... ....+.. ++++.+..++.. .++++.. T Consensus 84 ~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~~~~ 146 (420) T 4RV1_D 84 DAGGVEVLVKLLT-STDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTS----------------TDSEVQK 146 (420) T ss_dssp HTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTC----------------SCHHHHH T ss_pred HcChHHHHHHHhc-CCCHHHHHHHHHHHHHHhCCChHHHHHHHHcCHHHHHHHHHhC----------------CCHHHHH Confidence 3456677777776 5567788889999988876432 2222222 566666666542 1344444 Q NP_000290.2 405 NATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSY 484 (747) Q Consensus 405 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 484 (747) .+..++..-.... + .....+. ..+++..+...++. .+..-...+..+|.++.. T Consensus 147 ~a~~~l~~l~~~~------~--------------~~~~~~~-~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~ 199 (420) T 4RV1_D 147 EAARALANIASGP------D--------------EAIKAIV-DAGGVEVLVKLLTS------TDSEVQKEAARALANIAS 199 (420) T ss_dssp HHHHHHHHHHTSC------H--------------HHHHHHH-HTTHHHHHHHHTTC------SSHHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHhcCC------H--------------HHHHHHH-HCCHHHHHHHHhcC------CCHHHHHHHHHHHHHHhC Confidence 4443332211000 0 0000000 01333333333221 111111222222222211 Q NP_000290.2 485 RLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDAT 564 (747) Q Consensus 485 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eV 564 (747) .. ......+.+.++++.+...+. +.++.+ T Consensus 200 ~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~~~ 228 (420) T 4RV1_D 200 GP--------------------------------------------------TSAIKAIVDAGGVEVLVKLLT-STDSEV 228 (420) T ss_dssp SC--------------------------------------------------HHHHHHHHTTTHHHHHHHHTT-CSCHHH T ss_pred CC--------------------------------------------------HHHHHHHHHCCHHHHHHHHhh-CCCHHH Confidence 00 000111234456777888887 467788 Q NP_000290.2 565 LEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL-L-HRVMGNQVFPEVTR 642 (747) Q Consensus 565 r~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e-~-~~ll~~giI~~Ll~ 642 (747) +..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++.... . ..+...++++.+.. T Consensus 229 ~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~ 303 (420) T 4RV1_D 229 QKEAARALANIASGPDE-----AIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVK 303 (420) T ss_dssp HHHHHHHHHHHHTSCHH-----HHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHH T ss_pred HHHHHHHHHHHhCCCHH-----HHHHHhhccHHHHHHHHhCCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHH Confidence 88999999998864332 12233456788888888888888899999999999987632 2 23344467777888 Q NP_000290.2 643 LLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 643 LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ++.+ .++.++..++.+|.+++...+.....+...+.++.+..++.+. ++.++..++.+|.+++... T Consensus 304 ~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~a~~~l~~l~~~~ 369 (420) T 4RV1_D 304 LLTS------TDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTST-DSEVQKEAARALANIASGP 369 (420) T ss_dssp HTTC------SCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCS-CHHHHHHHHHHHHHHHTSC T ss_pred HccC------CCHHHHHHHHHHHHHHHcChHHHHHHHHHCCHHHHHHHHhCCC-CHHHHHHHHHHHHHHHcCC Confidence 7776 3678899999999999876444444455556788888888766 7889999999999998764 No 9 >6S9O_F designed Armadillo repeat protein with; peptide binder, repeat protein, designed; HET: CA, EDO; 3.17A {synthetic construct} Probab=98.47 E-value=2.8e-11 Score=117.85 Aligned_cols=167 Identities=20% Similarity=0.267 Sum_probs=122.0 Template_Neff=13.100 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++++.++.++. +.++.++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++. T Consensus 170 ~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~ 243 (344) T 6S9O_F 170 DAGALPALVQLLS-SPNEQILQLALWALSNIASGGNE-----QIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIAS 243 (344) T ss_dssp HTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHH-----HHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTT T ss_pred hCCcHHHHHHHcc-CCCHHHHHHHHHHHHHHHcCChH-----HHHHHHhcChHHHHHHHccCCCHHHHHHHHHHHHHHHc Confidence 4456777888887 46777888899999998864332 12333445788888888888888899999999999986 Q NP_000290.2 625 H-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAE 702 (747) Q Consensus 625 ~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~ 702 (747) . ... ......++++.+..++.+ .++.++..++.+|.+++...+.....+.+.++++.+..++.+. ++.++. T Consensus 244 ~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~ 316 (344) T 6S9O_F 244 GGNEQIQAVIDAGALPALVQLLSS------PNEQILQEALWALSNIASGGNEQKQAVKEAGALEKLEQLQSHE-NEKIQK 316 (344) T ss_dssp SCHHHHHHHHHTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGCS-CHHHHH T ss_pred CcHHHHHHHHHCChHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCHHHHHHHHhhCC-CHHHHH Confidence 5 222 233445677778887766 3678889999999999876555555555556788888888766 788999 Q NP_000290.2 703 AARLLLSDMWSSKELQGVLRQQ 724 (747) Q Consensus 703 aAL~aLsnL~~~~~~~~~~~~~ 724 (747) .++.+|.+++...+.....+.. T Consensus 317 ~a~~~l~~l~~~~~~~~~~~~~ 338 (344) T 6S9O_F 317 EAQEALEKLQSHGSGGSGKRKR 338 (344) T ss_dssp HHHHHHHHHHHCSCCCCCCCBC T ss_pred HHHHHHHHHHhcccCCCchhcc Confidence 9999999998776654444333 No 10 >5MFD_C YIIIM''6AII, Capsid decoration protein,pD_(KR)5; Designed armadillo repeat protein, peptide; HET: CA; 2.3A {synthetic construct} Probab=98.46 E-value=3e-11 Score=116.21 Aligned_cols=318 Identities=20% Similarity=0.263 Sum_probs=178.1 Template_Neff=13.300 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+....+.....+...++++.+...+.+.++.++..++.++..+..........+ T Consensus 5 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 84 (328) T 5MFD_C 5 ELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAV 84 (328) T ss_dssp CHHHHHHHHHSSCHHHHHHHHHHHHHHHTSCHHHHHHHHHHTCHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCcHHHHHHH Confidence 45556666666777888889999988876544333334445677788888877778888889998888875433322223 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++.. .++++. T Consensus 85 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~~~ 147 (328) T 5MFD_C 85 IDAGALPALVQLLS-SPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSS----------------PNEQIL 147 (328) T ss_dssp HHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGC----------------SCHHHH T ss_pred hhcCHHHHHHHHcc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHhcC----------------CCHHHH Confidence 33345666666665 4455666777777777665321 1111111 334444433321 011111 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) .. ++..|.++. T Consensus 148 ~~---------------------------------------------------------------------a~~~l~~l~ 158 (328) T 5MFD_C 148 QE---------------------------------------------------------------------ALWTLGNIA 158 (328) T ss_dssp HH---------------------------------------------------------------------HHHHHHHHT T ss_pred HH---------------------------------------------------------------------HHHHHHHHH Confidence 11 111222221 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ...+ .....+.+.++++.++.++. +.++. T Consensus 159 ~~~~--------------------------------------------------~~~~~~~~~~~~~~l~~~l~-~~~~~ 187 (328) T 5MFD_C 159 SGGN--------------------------------------------------EQIQAVIDAGALPALVQLLS-SPNEQ 187 (328) T ss_dssp TSCH--------------------------------------------------HHHHHHHHTTHHHHHHHGGG-CSCHH T ss_pred cCCH--------------------------------------------------HHHHHHHHCCcHHHHHHHhc-CCCHH Confidence 0000 00000122345556666665 35556 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFPEVT 641 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~~Ll 641 (747) ++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.++.+++.. +.. ......++++.+. T Consensus 188 ~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~ 262 (328) T 5MFD_C 188 ILQEALWTLGNIASGGNE-----QIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALV 262 (328) T ss_dssp HHHHHHHHHHHHHTSCHH-----HHHHHHHTTCHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHH T ss_pred HHHHHHHHHHHHHcCCHH-----HHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHH Confidence 666777777777654221 122223445667777777666667777777777777654 222 2223345666666 Q NP_000290.2 642 RLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMW 712 (747) Q Consensus 642 ~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~ 712 (747) .++.+ .++.++..++.+|.+++...+.....+.+.++++.+..++.+. ++.++..++.+|.+++ T Consensus 263 ~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~ 326 (328) T 5MFD_C 263 QLLSS------PNEQILQEALWTLGNIASGGNEQKQAVKEAGALEKLEQLQSHE-NEKIQKEAQEALEKLQ 326 (328) T ss_dssp HGGGC------SCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHGGGCS-CHHHHHHHHHHHHHHH T ss_pred HHhcC------CCHHHHHHHHHHHHHHhCCcHHHHHHHHHCCHHHHHHHHhhCC-CHHHHHHHHHHHHHHh Confidence 66655 2566777777777777765444444444445667777777655 6677777777777665 No 11 >4MZ6_E Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Importin; ARM repeat, protein transport, Importin; 1.88A {Mus musculus} Probab=98.45 E-value=3.5e-11 Score=125.01 Aligned_cols=368 Identities=14% Similarity=0.178 Sum_probs=227.8 Template_Neff=12.800 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAK-QQVYQLGGICKLVDLLRSPN-QNVQQAAAGALRNLVFRSTTN 321 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~-~~li~~~IL~~Ll~lL~s~d-~eVr~~AL~aLs~La~~~~~~ 321 (747) ..+++.+...+.+.++.++..++.++..+........ ..+...++++.+...+...+ +.++..++.++..++...... T Consensus 56 ~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~~ 135 (509) T 4MZ6_E 56 NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQ 135 (509) T ss_dssp TCCHHHHHHHHTTCCHHHHHHHHHHHHHHHTCSSCCCHHHHHHTTHHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHH T ss_pred hhhHHHHHHHHcCCCHHHHHHHHHHHHHHHcCCCCCCHHHHHHCCcHHHHHHHhcCCCChHHHHHHHHHHHHHhCCCHHH Confidence 4456667777777788889999999988876433211 22333456777777776543 678888999998887654433 Q NP_000290.2 322 KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVD 399 (747) Q Consensus 322 ~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~ 399 (747) ...+...++++.+...+. ..++.++..++.++..++..... ...+.. ++++.|+.++..... +..+ T Consensus 136 ~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~-----------~~~~ 203 (509) T 4MZ6_E 136 TKAVVDGGAIPAFISLLA-SPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDL-----------STLA 203 (509) T ss_dssp HHHHHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHHTCSSCG-----------GGSC T ss_pred HHHHHhcChHHHHHHHhc-CCChhHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHHhCCCh-----------hhhh Confidence 333444467777888886 56778889999999998875432 222223 677777777764211 1122 Q NP_000290.2 400 PEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVL 479 (747) Q Consensus 400 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 479 (747) +++...+..+|..-. .............+++..+...+.. -+......+...| T Consensus 204 ~~~~~~~~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l 256 (509) T 4MZ6_E 204 CGYLRNLTWTLSNLC---------------------RNKNPAPPLDAVEQILPTLVRLLHH------NDPEVLADSCWAI 256 (509) T ss_dssp HHHHHHHHHHHHHHH---------------------CCCSSCCCHHHHHHHHHHHHHHTTC------SCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHh---------------------cCCCCCCCHHHHHHHHHHHHHHHhC------CCHHHHHHHHHHH Confidence 333333333332211 0000011111112334444333321 1111222222223 Q NP_000290.2 480 HNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKS 559 (747) Q Consensus 480 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss 559 (747) .++...- ......+.+.++++.|+.++. + T Consensus 257 ~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~ 285 (509) T 4MZ6_E 257 SYLTDGP--------------------------------------------------NERIEMVVKKGVVPQLVKLLG-A 285 (509) T ss_dssp HHHTSSS--------------------------------------------------HHHHHHHHTTTCHHHHHHHHT-C T ss_pred HHHhcCC--------------------------------------------------hHHHHHHhhCChHHHHHHHhc-C Confidence 3222100 001112244567888888887 4 Q NP_000290.2 560 KKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVF 637 (747) Q Consensus 560 ~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI 637 (747) .++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. +.. ..+...+++ T Consensus 286 ~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~ 360 (509) T 4MZ6_E 286 TELPIVTPALRAIGNIVTGTDE-----QTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLV 360 (509) T ss_dssp SCHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTGGGGHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHH T ss_pred CCcchHHHHHHHHHHHhcCCHH-----HHHHHHhCChHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCHH Confidence 6778888999999999875332 233334567888899999888889999999999999876 322 233445678 Q NP_000290.2 638 PEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS-QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 638 ~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~-s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) +.++.++.+ .++.++..++.+|.+++.. .+.....+.+.++++.|..++.+. ++.++..++.+|.+++. T Consensus 361 ~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~ 430 (509) T 4MZ6_E 361 PFLVGVLSK------ADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAK-DTKIIQVILDAISNIFQ 430 (509) T ss_dssp HHHHHHHHS------SCHHHHHHHHHHHHHHHHHSCHHHHHHHHHTTCHHHHHHGGGCS-CHHHHHHHHHHHHHHHH T ss_pred HHHHHHhcC------CCHHHHHHHHHHHHHHHcCCCHHHHHHHHhCCCHHHHHHHHhCC-CHHHHHHHHHHHHHHHH Confidence 888888876 3678899999999999874 234444555556788888888876 78899999999999987 No 12 >5UMZ_B Importin subunit alpha-1, TNRC6A; mRNA decay, miRNA ARM repeat; HET: GOL; 1.9A {Mus musculus} Probab=98.45 E-value=3.5e-11 Score=125.01 Aligned_cols=368 Identities=14% Similarity=0.178 Sum_probs=227.8 Template_Neff=12.800 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAK-QQVYQLGGICKLVDLLRSPN-QNVQQAAAGALRNLVFRSTTN 321 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~-~~li~~~IL~~Ll~lL~s~d-~eVr~~AL~aLs~La~~~~~~ 321 (747) ..+++.+...+.+.++.++..++.++..+........ ..+...++++.+...+...+ +.++..++.++..++...... T Consensus 56 ~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~~ 135 (509) T 5UMZ_B 56 NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQ 135 (509) T ss_dssp SCCHHHHHHHHTSSCHHHHHHHHHHHHHHHTSSSCCCHHHHHHTTCHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHH T ss_pred hhhHHHHHHHHcCCCHHHHHHHHHHHHHHHcCCCCCCHHHHHHCCcHHHHHHHhcCCCChHHHHHHHHHHHHHhCCCHHH Confidence 4456667777777788889999999988876433211 22333456777777776543 678888999998887654433 Q NP_000290.2 322 KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVD 399 (747) Q Consensus 322 ~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~ 399 (747) ...+...++++.+...+. ..++.++..++.++..++..... ...+.. ++++.|+.++..... +..+ T Consensus 136 ~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~-----------~~~~ 203 (509) T 5UMZ_B 136 TKAVVDGGAIPAFISLLA-SPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDL-----------STLA 203 (509) T ss_dssp HHHHHHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHHHTCHHHHHHHHHTTCHHHHHHHTCSSCG-----------GGSC T ss_pred HHHHHhcChHHHHHHHhc-CCChhHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHHhCCCh-----------hhhh Confidence 333444467777888886 56778889999999998875432 222223 677777777764211 1122 Q NP_000290.2 400 PEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVL 479 (747) Q Consensus 400 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 479 (747) +++...+..+|..-. .............+++..+...+.. -+......+...| T Consensus 204 ~~~~~~~~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l 256 (509) T 5UMZ_B 204 CGYLRNLTWTLSNLC---------------------RNKNPAPPLDAVEQILPTLVRLLHH------NDPEVLADSCWAI 256 (509) T ss_dssp HHHHHHHHHHHHHHH---------------------CCCSSCCCHHHHHHHHHHHHHHTTS------SCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHh---------------------cCCCCCCCHHHHHHHHHHHHHHHhC------CCHHHHHHHHHHH Confidence 333333333332211 0000011111112334444333321 1111222222223 Q NP_000290.2 480 HNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKS 559 (747) Q Consensus 480 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss 559 (747) .++...- ......+.+.++++.|+.++. + T Consensus 257 ~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~ 285 (509) T 5UMZ_B 257 SYLTDGP--------------------------------------------------NERIEMVVKKGVVPQLVKLLG-A 285 (509) T ss_dssp HHHTSSC--------------------------------------------------HHHHHHHHTTTCHHHHHHHHT-C T ss_pred HHHhcCC--------------------------------------------------hHHHHHHhhCChHHHHHHHhc-C Confidence 3222100 001112244567888888887 4 Q NP_000290.2 560 KKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVF 637 (747) Q Consensus 560 ~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI 637 (747) .++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. +.. ..+...+++ T Consensus 286 ~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~ 360 (509) T 5UMZ_B 286 TELPIVTPALRAIGNIVTGTDE-----QTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLV 360 (509) T ss_dssp SCHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTGGGGHHHHTTCSSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHH T ss_pred CCcchHHHHHHHHHHHhcCCHH-----HHHHHHhCChHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCHH Confidence 6778888999999999875332 233334567888899999888889999999999999876 322 233445678 Q NP_000290.2 638 PEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS-QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 638 ~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~-s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) +.++.++.+ .++.++..++.+|.+++.. .+.....+.+.++++.|..++.+. ++.++..++.+|.+++. T Consensus 361 ~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~ 430 (509) T 5UMZ_B 361 PFLVGVLSK------ADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAK-DTKIIQVILDAISNIFQ 430 (509) T ss_dssp HHHHHHHHS------SCHHHHHHHHHHHHHHHHHSCHHHHHHHHHTTCHHHHHHGGGCS-CHHHHHHHHHHHHHHHH T ss_pred HHHHHHhcC------CCHHHHHHHHHHHHHHHcCCCHHHHHHHHhCCCHHHHHHHHhCC-CHHHHHHHHHHHHHHHH Confidence 888888876 3678899999999999874 234444555556788888888876 78899999999999987 No 13 >2JDQ_A IMPORTIN ALPHA-1 SUBUNIT, POLYMERASE BASIC; TRANSPORT, PB2 SUBUNIT, NUCLEAR PROTEIN; 2.2A {HOMO SAPIENS} Probab=98.45 E-value=3.6e-11 Score=122.13 Aligned_cols=367 Identities=14% Similarity=0.163 Sum_probs=226.8 Template_Neff=13.000 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESA--KQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTT 320 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~--~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~ 320 (747) +.+++.+...+.+.++.++..++.+|..+....... ...+...++++.+...+.. .++.++..++.++..++..... T Consensus 19 ~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~ 98 (450) T 2JDQ_A 19 GVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSL 98 (450) T ss_dssp ---CHHHHHHHHSSCHHHHHHHHHHHHHHHHSSSSCCHHHHHTSTTHHHHHHHHHTCTTCHHHHHHHHHHHHHHHSSCHH T ss_pred CcccHHHHHHHhcCCHHHHHHHHHHHHHHHccCCCCCHhHHhcCcchHHHHHHHHccCCCHHHHHHHHHHHHHHhCCCcH Confidence 445567777788788889999999999887532211 1222224667777777765 5677888899999888765443 Q NP_000290.2 321 NKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVV 398 (747) Q Consensus 321 ~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~ 398 (747) ....+...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.++.++... . T Consensus 99 ~~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~ 162 (450) T 2JDQ_A 99 QTRIVIQAGAVPIFIELLS-SEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQ---------------N 162 (450) T ss_dssp HHHHHHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHHTTSC---------------C T ss_pred HHHHHHHcChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCChHHHHHHHHCCCHHHHHHHHhhc---------------c Confidence 3333333467777888876 5567888899999998887543 2223333 6777777776431 1 Q NP_000290.2 399 DPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCV 478 (747) Q Consensus 399 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 478 (747) ++++...+..++..-.. ............+++..+...+.. -+..-...+... T Consensus 163 ~~~~~~~a~~~l~~l~~---------------------~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~ 215 (450) T 2JDQ_A 163 RLTMTRNAVWALSNLCR---------------------GKSPPPEFAKVSPCLNVLSWLLFV------SDTDVLADACWA 215 (450) T ss_dssp CHHHHHHHHHHHHHHHC---------------------CSSSCCCGGGTGGGHHHHHHHTTC------CCHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHhc---------------------CCCCCchhhhhhhHHHHHHHHhcC------CCHHHHHHHHHH Confidence 23443344333322110 000111111222333333332221 111122222223 Q NP_000290.2 479 LHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK 558 (747) Q Consensus 479 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s 558 (747) |.++...- ......+.+.++++.++.++. T Consensus 216 l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~- 244 (450) T 2JDQ_A 216 LSYLSDGP--------------------------------------------------NDKIQAVIDAGVCRRLVELLM- 244 (450) T ss_dssp HHHHTSSS--------------------------------------------------HHHHHHHHHTTTHHHHHHHTT- T ss_pred HHHHhcCC--------------------------------------------------HHHHHHHHHCCHHHHHHHHHc- Confidence 33222110 001112245567888888887 Q NP_000290.2 559 SKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQV 636 (747) Q Consensus 559 s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~gi 636 (747) +.++.++..++.+|.+++...+. ....+.+.++++.+..++.+.++.++..++.+|.+++... .. ......++ T Consensus 245 ~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~ 319 (450) T 2JDQ_A 245 HNDYKVVSPALRAVGNIVTGDDI-----QTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANI 319 (450) T ss_dssp CSCHHHHHHHHHHHHHHTTSCHH-----HHHHHHTTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTH T ss_pred CCCHHHHHHHHHHHHHHhhCChH-----HHHHHhhcchHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHhCCH Confidence 46778888999999999875332 2233345578888999998888889999999999998762 22 23344567 Q NP_000290.2 637 FPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQ-PQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 637 I~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s-~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ++.+..++.+ .++.++..++.+|.+++... +.....+.+.++++.+..++.+. ++.++..++.+|.+++... T Consensus 320 ~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~~~ 392 (450) T 2JDQ_A 320 FPALISILQT------AEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVM-DSKIVQVALNGLENILRLG 392 (450) T ss_dssp HHHHHHHHHH------SCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHTCHHHHHHGGGSS-CHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHhc------CCHHHHHHHHHHHHHHhcCCCHHHHHHHHHCCcHHHHHHHhhCC-CHHHHHHHHHHHHHHHHHh Confidence 8888888876 36788899999999998752 34445555556788888888876 7889999999999998765 Q NP_000290.2 716 E 716 (747) Q Consensus 716 ~ 716 (747) + T Consensus 393 ~ 393 (450) T 2JDQ_A 393 E 393 (450) T ss_dssp H T ss_pred H Confidence 4 No 14 >4E4V_A Importin subunit alpha-2; armadillo repeat, karyopherin, importin, nuclear; HET: GOL, DTT; 2.5283A {Homo sapiens} Probab=98.45 E-value=3.6e-11 Score=124.32 Aligned_cols=364 Identities=17% Similarity=0.189 Sum_probs=218.6 Template_Neff=12.700 Q NP_000290.2 246 TIPKAVQYLSSQD-EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd-~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+.+ +.++..++.++..++.........+...++++.+..++.+.++.++..++.++..++......... T Consensus 76 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 155 (485) T 4E4V_A 76 LIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDL 155 (485) T ss_dssp CHHHHHHHTTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHHTTCHHHHHH T ss_pred cHHHHHHHhcCCCChHHHHHHHHHHHHHhcCChHHHHHHHhcChHHHHHHHhcCCChhHHHHHHHHHHHHhcCCHHHHHH Confidence 4555666665443 678888889988887654433334444567778888888777888999999999888654432333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNA-----EIQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~-----eVr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) +...++++.+...+. .... .++..++.++..++.......... .++++.+..++.. T Consensus 156 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~---------------- 218 (485) T 4E4V_A 156 VIKYGAVDPLLALLA-VPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHH---------------- 218 (485) T ss_dssp HHHTTCHHHHHHTTC-SSCGGGSCHHHHHHHHHHHHHHTCCCSSCCCHHHHHHHHHHHHHHTTS---------------- T ss_pred HHHCCcHHHHHHHHh-CCCcccchHHHHHHHHHHHHHHHhCCCCCCCHHHHhcHHHHHHHHhcC---------------- Confidence 333456666776665 2222 567778888888876443222222 2556666666542 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) .|+++...+..+|..-.. .+......---.+++..|...+.. .+..-...+.. T Consensus 219 ~~~~~~~~a~~~l~~l~~---------------------~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~ 271 (485) T 4E4V_A 219 DDPEVLADTCWAISYLTD---------------------GPNERIGMVVKTGVVPQLVKLLGA------SELPIVTPALR 271 (485) T ss_dssp CCHHHHHHHHHHHHHHTS---------------------SCHHHHHHHHTTTCHHHHHHHHTC------SCHHHHHHHHH T ss_pred CCHHHHHHHHHHHHHHhc---------------------CChHHhhHHhhCChHHHHHHHhcC------CChHHHHHHHH Confidence 134444444444432110 000000000012233333333221 11222223333 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) +|.++...- ......+.+.++++.|+.++. T Consensus 272 ~l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~ 301 (485) T 4E4V_A 272 AIGNIVTGT--------------------------------------------------DEQTQVVIDAGALAVFPSLLT 301 (485) T ss_dssp HHHHHTTSC--------------------------------------------------HHHHHHHHHTTGGGGHHHHHT T ss_pred HHHHHhcCC--------------------------------------------------HHHHHHHHhCChHHHHHHHhc Confidence 333332100 001112234567888888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGN 634 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~ 634 (747) +.++.++..++.+|.+++...+. ....+...++++.|+.++.+.++.++..++.+|.+++.. . .. ..+... T Consensus 302 -~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~ 375 (485) T 4E4V_A 302 -NPKTNIQKEATWTMSNITAGRQD-----QIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHC 375 (485) T ss_dssp -CSSHHHHHHHHHHHHHHHTSCHH-----HHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHSCHHHHHHHHHT T ss_pred -CCCHHHHHHHHHHHHHHcCCCHH-----HHHHHHHCCHHHHHHHHHhcCCHHHHHHHHHHHHHHHhcCCHHHHHHHHhC Confidence 46778888999999999875332 233334557888899999888888999999999999875 2 12 233445 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQ------PQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s------~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ++++.+..++.+ .++.++..++.+|.+++... +.....+.+.++++.|..++.+. ++.++..++.+| T Consensus 376 ~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l 448 (485) T 4E4V_A 376 GIIEPLMNLLTA------KDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE-NESVYRASLSLI 448 (485) T ss_dssp TCHHHHHHGGGC------SCHHHHHHHHHHHHHHHHHHHHTTCHHHHHHHHHHTTHHHHHHTTCCTT-SHHHHHHHHHHH T ss_pred CcHHHHHHHhhc------CCHHHHHHHHHHHHHHHHHHHHhCChhHHHHHHHHcCHHHHHHHHHhCC-CHHHHHHHHHHH Confidence 677888888776 36788999999999998731 22333344456788888888766 788999999999 Q NP_000290.2 709 SDMWSSKE 716 (747) Q Consensus 709 snL~~~~~ 716 (747) .+++...+ T Consensus 449 ~~l~~~~~ 456 (485) T 4E4V_A 449 EKYFSVEE 456 (485) T ss_dssp HHHCC--- T ss_pred HHHcCccc Confidence 99986543 No 15 >4B18_A IMPORTIN SUBUNIT ALPHA-1, TELOMERASE REVERSE; TRANSPORT PROTEIN - PEPTIDE COMPLEX; 2.52A {HOMO SAPIENS} Probab=98.44 E-value=4e-11 Score=121.64 Aligned_cols=368 Identities=14% Similarity=0.162 Sum_probs=227.4 Template_Neff=13.000 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES--AKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTT 320 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~--~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~ 320 (747) +.+++.+...+.+.++.++..++.+|..+...... ....+...++++.+...+.. .++.++..++.++..++..... T Consensus 16 ~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~ 95 (447) T 4B18_A 16 GVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSL 95 (447) T ss_dssp CSSCHHHHHHHTSSCHHHHHHHHHHHHHHHHCSSCCCHHHHHTSTTHHHHHHHHTTCTTCHHHHHHHHHHHHHHTSSCHH T ss_pred CCCcHHHHHHHhcCCHHHHHHHHHHHHHHhCCCCCCCHhHHhcCccHHHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCcH Confidence 44556677777777888899999999888753221 11222224667777777765 5677888899999888765433 Q NP_000290.2 321 NKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVV 398 (747) Q Consensus 321 ~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~ 398 (747) ....+...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.|+.++... . T Consensus 96 ~~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~ 159 (447) T 4B18_A 96 QTRIVIQAGAVPIFIELLS-SEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQ---------------N 159 (447) T ss_dssp HHHHHHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHGGGCT---------------T T ss_pred HHHHHHHcChHHHHHHHhh-CCCHHHHHHHHHHHHHHHccChhHHHHHHHCCcHHHHHHHhhcC---------------C Confidence 3223333467777888776 5567888899999998887543 2223333 6677777766431 1 Q NP_000290.2 399 DPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCV 478 (747) Q Consensus 399 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 478 (747) ++++...+..+|..-. .............+++..+...++. -+......+... T Consensus 160 ~~~~~~~~~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~ 212 (447) T 4B18_A 160 RLTMTRNAVWALSNLC---------------------RGKSPPPEFAKVSPCLNVLSWLLFV------SDTDVLADACWA 212 (447) T ss_dssp CHHHHHHHHHHHHHHH---------------------CCSSSCCCHHHHGGGHHHHHHHTTS------CCHHHHHHHHHH T ss_pred ChhHHHHHHHHHHHHh---------------------cCCCCCCcccccccHHHHHHHHhhC------CCHHHHHHHHHH Confidence 2344333333332211 0000111111122333333322211 111112222222 Q NP_000290.2 479 LHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK 558 (747) Q Consensus 479 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s 558 (747) |.++...- ......+.+.++++.++.++. T Consensus 213 l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~- 241 (447) T 4B18_A 213 LSYLSDGP--------------------------------------------------NDKIQAVIDAGVCRRLVELLM- 241 (447) T ss_dssp HHHHTSSS--------------------------------------------------HHHHHHHHHTTCHHHHHHHTT- T ss_pred HHHHhcCC--------------------------------------------------HHHHHHHHHCCHHHHHHHHHc- Confidence 32222100 001112245567888888887 Q NP_000290.2 559 SKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQV 636 (747) Q Consensus 559 s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~gi 636 (747) +.++.++..++.+|.+++...+. ....+.+.++++.|..++.+.++.++..++.+|.+++... .. ......++ T Consensus 242 ~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~ 316 (447) T 4B18_A 242 HNDYKVVSPALRAVGNIVTGDDI-----QTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANI 316 (447) T ss_dssp CSCHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTH T ss_pred CCCHHHHHHHHHHHHHHhcCChH-----HHHHHhhcchHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHhCCh Confidence 46778888999999999875332 2233345578888999998888889999999999998762 22 23344567 Q NP_000290.2 637 FPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS-QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 637 I~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~-s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ++.+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.+|.+++... T Consensus 317 ~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~~~ 389 (447) T 4B18_A 317 FPALISILQT------AEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVM-DSKIVQVALNGLENILRLG 389 (447) T ss_dssp HHHHHHHHHH------SCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHTCHHHHHHGGGSS-CHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHhc------CCHHHHHHHHHHHHHHhccCCHHHHHHHHHCCcHHHHHHHhhCC-CHHHHHHHHHHHHHHHHHh Confidence 8888888876 3678899999999999875 234445555556788888888876 7889999999999998765 Q NP_000290.2 716 EL 717 (747) Q Consensus 716 ~~ 717 (747) +. T Consensus 390 ~~ 391 (447) T 4B18_A 390 EQ 391 (447) T ss_dssp HH T ss_pred HH Confidence 43 No 16 >4XZR_B Heh1-NLS, Kap60; karyopherins nuclear import ; 2.25A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=98.43 E-value=4.3e-11 Score=119.82 Aligned_cols=363 Identities=16% Similarity=0.214 Sum_probs=223.0 Template_Neff=13.200 Q NP_000290.2 248 PKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLRSPN-QNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 248 ~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~s~d-~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +.+...+.+.++.++..++..+..++..... ........++++.+...+...+ +.++..++.++..++.........+ T Consensus 4 ~~l~~~l~~~~~~~~~~a~~~l~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 83 (423) T 4XZR_B 4 PQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVV 83 (423) T ss_dssp SSSSTTTSSSCHHHHHHHHHHHHHHHSCSSSCCHHHHHTTTCHHHHHHTTSTTSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred hhHhhhcChHhHHHHHHHHHHHHHHHcCCCCCchHHHHhCCcHHHHHHHhhCCCCHHHHHHHHHHHHHHhCCCchhhhHH Confidence 4455566667777888888888877654321 1222333466777777776543 6778889999988876543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ...++++.+...+. +.++.++..++.++..++... .....+.. ++++.|..++... ++++. T Consensus 84 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~v~ 146 (423) T 4XZR_B 84 VDADAVPLFIQLLY-TGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSN----------------KPSLI 146 (423) T ss_dssp HHTTCHHHHHHHHH-HSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHHTTSC----------------CHHHH T ss_pred cccchHHHHHHHHh-CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCcHHHHHHHHhcC----------------CHHHH Confidence 33467777777776 567788899999999988753 22233333 6677777766521 34444 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-.. .........-..+.++.|...++. .+......+...|.++. T Consensus 147 ~~a~~~l~~l~~---------------------~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~ 199 (423) T 4XZR_B 147 RTATWTLSNLCR---------------------GKKPQPDWSVVSQALPTLAKLIYS------MDTETLVDACWAISYLS 199 (423) T ss_dssp HHHHHHHHHHHC---------------------CCTTCCCHHHHGGGHHHHHHHTTC------SCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHHc---------------------CCCCCCChHHhccHHHHHHHHhhC------CCHHHHHHHHHHHHHHh Confidence 444444432111 000001111122334444333321 11112222222333322 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) .. +......+.+.++++.++.++. +.++. T Consensus 200 ~~--------------------------------------------------~~~~~~~~~~~~~~~~l~~~l~-~~~~~ 228 (423) T 4XZR_B 200 DG--------------------------------------------------PQEAIQAVIDVRIPKRLVELLS-HESTL 228 (423) T ss_dssp SS--------------------------------------------------SHHHHHHHHHTTHHHHHHHHTT-CSCHH T ss_pred cC--------------------------------------------------CHHHHHHHHhcCHHHHHHHHhc-CCCHH Confidence 11 0011122345567888888887 46778 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVFPEVT 641 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI~~Ll 641 (747) ++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++... .. ..+...++++.+. T Consensus 229 ~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~ 303 (423) T 4XZR_B 229 VQTPALRAVGNIVTGNDL-----QTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLV 303 (423) T ss_dssp HHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHH T ss_pred HHHHHHHHHHHHHcCCHH-----HHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHH Confidence 888999999999865332 2223334578888888888888889999999999998762 22 3334556778888 Q NP_000290.2 642 RLLTSHTGNTSNSEDILSSACYTVRNLMASQP---QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKEL 717 (747) Q Consensus 642 ~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~---e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~~ 717 (747) .++.+ .++.++..++.+|.+++.... .....+.+.++++.+..++.+. ++.++..++.+|.+++...+. T Consensus 304 ~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~l~~l~~~~~~ 375 (423) T 4XZR_B 304 KLLEV------AEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIA-DNRIIEVTLDALENILKMGEA 375 (423) T ss_dssp HHHHH------SCHHHHHHHHHHHHHHHHGGGTCHHHHHHHHHTTCHHHHHHHTTTS-CHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHh------CCchHHHHHHHHHHHHHhCCCCCHHHHHHHHHCCcHHHHHHHhhcC-CHHHHHHHHHHHHHHHHHHHH Confidence 88866 367889999999999987532 2234445556788888888876 788899999999999876554 No 17 >5XZX_A Importin subunit alpha-3, Ran-binding protein; nuclear import, TRANSPORT PROTEIN; 3.0A {Homo sapiens} Probab=98.43 E-value=4.3e-11 Score=119.52 Aligned_cols=133 Identities=19% Similarity=0.169 Sum_probs=87.0 Template_Neff=13.200 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) ++.+...+.+.++.++..++.+|..+...... ....+...++++.+...+. ..++.++..++.++..++......... T Consensus 4 ~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 83 (416) T 5XZX_A 4 LEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQA 83 (416) T ss_dssp HHHHHHHTTCSSHHHHHHHHHHHHHTTSSSSSCCHHHHHTTTCHHHHHHHTTCTTCHHHHHHHHHHHHHHHTSCHHHHHH T ss_pred HHHHHHHHhcCCHHHHHHHHHHHHHHHhCCCCCCHHHHHHcCcHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCChHHHHH Confidence 44566666677778888999999888764321 1122333456777777776 456778888899998887654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVI 380 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~ 380 (747) +...++++.+...+. +.++.++..++.++..++... .....+.. ++++.|..++. T Consensus 84 ~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 140 (416) T 5XZX_A 84 VVQSNAVPLFLRLLH-SPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFIS 140 (416) T ss_dssp HHHTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHHTTCHHHHHHHHHHTCHHHHTTSCS T ss_pred HHhcChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCccHHHHHHhcC Confidence 334457777777776 567788899999999988652 22222333 66677776664 No 18 >1JDH_A BETA-CATENIN, hTcf-4; BETA-CATENIN, TCF4, PROTEIN-PROTEIN COMPLEX, TRANSCRIPTION; 1.9A {Homo sapiens} SCOP: a.118.1.1 Probab=98.42 E-value=4.4e-11 Score=123.86 Aligned_cols=378 Identities=19% Similarity=0.226 Sum_probs=227.0 Template_Neff=13.100 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..++.........+...++++.+...+.+.++.++..++.++..++......... T Consensus 101 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 180 (529) T 1JDH_A 101 GGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLI 180 (529) T ss_dssp THHHHHHHHTTCSCHHHHHHHHHHHHHHHHHCTTHHHHHHHHTHHHHHHHGGGCCCHHHHHHHHHHHHHHHTTCHHHHHH T ss_pred CCHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCcchHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHH Confidence 34556666666667788888999998887654333333334567777888887777888899999999888544433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) +...++++.+...+....+..++..++.++..+.........+.. ++++.+..++... ++++. T Consensus 181 ~~~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~~ 244 (529) T 1JDH_A 181 ILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDP----------------SQRLV 244 (529) T ss_dssp HHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTSTTHHHHHHHTTHHHHHHTTTTSS----------------CHHHH T ss_pred HHHCChhHHHHHHHccCCcHHHHHHHHHHHHHHhcCCccHHHHHHCCHHHHHHHHccCC----------------CHHHH Confidence 444457777777776333567888888888888875443333333 6667776666432 23333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-. ........+ .+++..+...++. -+..-...+...|.++. T Consensus 245 ~~~~~~l~~l~---------------------~~~~~~~~~---~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 294 (529) T 1JDH_A 245 QNCLWTLRNLS---------------------DAATKQEGM---EGLLGTLVQLLGS------DDINVVTCAAGILSNLT 294 (529) T ss_dssp HHHHHHHHHHH---------------------TTCTTCSCC---HHHHHHHHHHTTC------SCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHc---------------------chhhhHHHH---chHHHHHHHHhCC------CCHHHHHHHHHHHHHHh Confidence 33333332110 000000001 2334444333321 11111222223333332 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK-SKKD 562 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s-s~d~ 562 (747) ... ......+.+.++++.++..+.. ..++ T Consensus 295 ~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~~~~~~~ 324 (529) T 1JDH_A 295 CNN--------------------------------------------------YKNKMMVCQVGGIEALVRTVLRAGDRE 324 (529) T ss_dssp TTC--------------------------------------------------HHHHHHHHHTTHHHHHHHHHHHHTTCH T ss_pred cCC--------------------------------------------------HHHHHHHHHcCHHHHHHHHHHhcCCCh Confidence 110 0001112345667777776641 2456 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEV 640 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~L 640 (747) .++..++.+|.+++..... .......+...++++.+..++.+. ++.++..++.+|.+++..... ..+...++++.+ T Consensus 325 ~~~~~a~~~l~~l~~~~~~--~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l 402 (529) T 1JDH_A 325 DITEPAICALRHLTSRHQE--AEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRL 402 (529) T ss_dssp HHHHHHHHHHHHHTSSSTT--HHHHHHHHHHTTCHHHHHHTTSTTCCHHHHHHHHHHHHHHTTSGGGHHHHHHTTHHHHH T ss_pred HhHHHHHHHHHHHhcCccc--HHHHHHHHHhcccHHHHHHHHCCCCCHHHHHHHHHHHHHHhcChhhhHHHHhcCHHHHH Confidence 7788899999998865331 000012222456788888888765 678899999999999876433 334455677888 Q NP_000290.2 641 TRLLTSHTGNTSNS--------------------EDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 641 l~LL~s~s~~~~~d--------------------~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) ..++.... .+ +.++..++.+|.+++.. ......+...++++.++.++.+. ++.+ T Consensus 403 ~~~l~~~~----~~~~~~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~l~~~-~~~~~~~~~~~~~~~l~~~l~~~-~~~~ 476 (529) T 1JDH_A 403 VQLLVRAH----QDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARD-VHNRIVIRGLNTIPLFVQLLYSP-IENI 476 (529) T ss_dssp HHHHHHHH----HHHC-----------CBTTBCHHHHHHHHHHHHHHHTTS-HHHHHHHHHTTCHHHHHHGGGCS-CHHH T ss_pred HHHHHhcC----hhHHHHHhccCcchhHhccCCHHHHHHHHHHHHHHHhcC-ccchHHHHhcCcHHHHHHHhcCC-CHHH Confidence 88876520 01 67888999999999875 34444455556788888888876 7889 Q NP_000290.2 701 AEAARLLLSDMWSSKELQGVLRQQGF 726 (747) Q Consensus 701 r~aAL~aLsnL~~~~~~~~~~~~~~~ 726 (747) +..++.+|.+++...+....+...|+ T Consensus 477 ~~~a~~~l~~l~~~~~~~~~~~~~~~ 502 (529) T 1JDH_A 477 QRVAAGVLCELAQDKEAAEAIEAEGA 502 (529) T ss_dssp HHHHHHHHHHHTTSHHHHHHHHHTTC T ss_pred HHHHHHHHHHHhcCHHHHHHHHHcCc Confidence 99999999999987765544444443 No 19 >3IFQ_A plakoglobin, E-cadherin; armadillo repeat, Cardiomyopathy, Cell adhesion; HET: SO4; 2.8A {Homo sapiens} Probab=98.42 E-value=4.5e-11 Score=124.53 Aligned_cols=381 Identities=19% Similarity=0.234 Sum_probs=227.1 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++..++.........+...++++.+...+.+.++.++..++.++..++.........+ T Consensus 104 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 183 (553) T 3IFQ_A 104 GIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLII 183 (553) T ss_dssp HHHHHHHGGGCCCHHHHHHHHHHHHHHHHHCTTHHHHHHHTTGGGGTGGGGGSSCHHHHHHHHHHHHHHHTTCHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHhcCChHHHHHHHhcCHHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666677888889999988876543333333335677788888877778888999999998876444333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFF 404 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~ 404 (747) ...++++.+...+....+..++..++.++..+.........+.. ++++.+..++... ++++.. T Consensus 184 ~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~~~ 247 (553) T 3IFQ_A 184 LANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSN----------------SPRLVQ 247 (553) T ss_dssp HHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTSTTHHHHHHHTTHHHHHHGGGGSS----------------CHHHHH T ss_pred HHCCHHHHHHHHHhcCCcHHHHHHHHHHHHHHhCCcchHHHHHHCchHHHHHHHHhcC----------------CHHHHH Confidence 34456777777776333567888888888888775444333443 6667777666531 233333 Q NP_000290.2 405 NATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSY 484 (747) Q Consensus 405 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 484 (747) .+..++..-.. ...... ...++++.+...++. .+..-...+...|.++.. T Consensus 248 ~a~~~l~~l~~---------------------~~~~~~---~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~ 297 (553) T 3IFQ_A 248 NCLWTLRNLSD---------------------VATKQE---GLESVLKILVNQLSV------DDVNVLTCATGTLSNLTC 297 (553) T ss_dssp HHHHHHHHHHT---------------------TCTTCS---CCHHHHHHHHTTTTC------CCHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHhCC---------------------hhHHHH---HHHHHHHHHHHHcCC------CCHHHHHHHHHHHHHHHc Confidence 33333322110 000011 112344444433321 111222233333333321 Q NP_000290.2 485 RLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK-SKKDA 563 (747) Q Consensus 485 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s-s~d~e 563 (747) ... .....+.+.++++.++..+.. ..++. T Consensus 298 ~~~--------------------------------------------------~~~~~~~~~~~~~~l~~~l~~~~~~~~ 327 (553) T 3IFQ_A 298 NNS--------------------------------------------------KNKTLVTQNSGVEALIHAILRAGDKDD 327 (553) T ss_dssp TCH--------------------------------------------------HHHHHHTTTTHHHHHHHHHHHHTTCHH T ss_pred CCH--------------------------------------------------HHHHHHHHccHHHHHHHHHHHcCCChH Confidence 100 001122345677777776652 14566 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN-SDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVT 641 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d-~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll 641 (747) ++..++.+|.+++..... ... ....+...++++.+..++.+.+ +.++..++.+|.+++..... ......++++.+. T Consensus 328 ~~~~a~~~l~~l~~~~~~-~~~-~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~ 405 (553) T 3IFQ_A 328 ITEPAVCALRHLTSRHPE-AEM-AQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLV 405 (553) T ss_dssp HHHHHHHHHHHHTSSSTT-HHH-HHHHHHTTTHHHHHHHGGGCTTCHHHHHHHHHHHHHHTTSGGGHHHHHHTTHHHHHH T ss_pred hHHHHHHHHHHHhcCCCh-HHH-HHHHHHHcchHHHHHHHHcCCCChHHHHHHHHHHHHHhcCcccHHHHHHccHHHHHH Confidence 788889999998865321 000 0112234567888888887654 78889999999999876433 2334456778888 Q NP_000290.2 642 RLLTSHTGN---------------TSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 642 ~LL~s~s~~---------------~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .++...... ......++..++.+|.+++.. +.....+...++++.++.++.+. ++.++..++. T Consensus 406 ~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~-~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~ 483 (553) T 3IFQ_A 406 QLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARD-PMNRMEIFRLNTIPLFVQLLYSS-VENIQRVAAG 483 (553) T ss_dssp HHHHHHHHHHHHHHHTTCCCTTCSSCCHHHHHHHHHHHHHHHTTS-HHHHHHHHHTTCHHHHHHHTTCS-CHHHHHHHHH T ss_pred HHHHHcCcchhHHHhhcccCccccCCCHHHHHHHHHHHHHHHhcC-hhhHHHHHHcCChHHHHHHHhCC-CHHHHHHHHH Confidence 877652100 000027788899999999874 44445555667888888888866 7889999999 Q NP_000290.2 707 LLSDMWSSKELQGVLRQQGF 726 (747) Q Consensus 707 aLsnL~~~~~~~~~~~~~~~ 726 (747) +|.+++...+....+.+.|. T Consensus 484 ~l~~l~~~~~~~~~~~~~~~ 503 (553) T 3IFQ_A 484 VLCELAQDKEAADAIDAEGA 503 (553) T ss_dssp HHHHHTTSHHHHHHHHHTTT T ss_pred HHHHHHcCHHHHHHHHHCCc Confidence 99999987766555554443 No 20 >4UAD_A Importin alpha import adaptor, Influenza; importin karyopherin complex NLS, PROTEIN; 2.42A {Homo sapiens} Probab=98.39 E-value=6e-11 Score=121.78 Aligned_cols=372 Identities=17% Similarity=0.175 Sum_probs=218.3 Template_Neff=12.900 Q NP_000290.2 246 TIPKAVQYLSS-QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~s-sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+ .++.++..++.++..++.........+...++++.+..++.+.+..++..++.++..++......... T Consensus 68 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 147 (479) T 4UAD_A 68 VVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDY 147 (479) T ss_dssp HHHHHHHHTTCTTCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHHTSCHHHHHH T ss_pred hHHHHHHHhhcCCCHHHHHHHHHHHHHHhCCCchHHHHHHHcCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHHH Confidence 45556666654 56778888899998887654333333333567777888887777888899999999887654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELI-A-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lv-e-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...+++..+...+....++.++..++.++..++.......... . ++++.++.++... ++++ T Consensus 148 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~ 211 (479) T 4UAD_A 148 VLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSS----------------DSDL 211 (479) T ss_dssp HHHTTCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCSSCCCGGGTGGGHHHHHHHTTCC----------------CHHH T ss_pred HHhCCcHHHHHHHhhcCCchHHHHHHHHHHHHHHcCCCCCchhhcccchHHHHHHHhcCC----------------CHHH Confidence 33345666677766533456788888888888876542222222 1 5666666666431 2333 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) -..+..++..-... .+ ...+.+ .-.+.+..|...++. .+..-...+...|.++ T Consensus 212 ~~~a~~~l~~l~~~------~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l 264 (479) T 4UAD_A 212 LADACWALSYLSDG------PN--------------EKIQAV-IDSGVCRRLVELLMH------NDYKVASPALRAVGNI 264 (479) T ss_dssp HHHHHHHHHHHTSS------SH--------------HHHHHH-HHTTCHHHHHHGGGC------SCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhcC------ch--------------HHHHHH-HhCCHHHHHHHHhcC------CCHHhHHHHHHHHHHH Confidence 33333333221100 00 000000 012333333333221 0111111222222222 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) .... ......+.+.++++.|+.++. +.++ T Consensus 265 ~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~ 293 (479) T 4UAD_A 265 VTGD--------------------------------------------------DIQTQVILNCSALPCLLHLLS-SPKE 293 (479) T ss_dssp TTSC--------------------------------------------------HHHHHHHHTTTCHHHHHHHTT-CSSH T ss_pred hcCC--------------------------------------------------HHHHHHHHhcChHHHHHHHhh-CCCH Confidence 2100 000112234567888888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH--PLL-HRVMGNQVFPE 639 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~--~e~-~~ll~~giI~~ 639 (747) .++..++.+|.+++...+. ....+.+.++++.|..++.+.++.++..++.+|.+++.. ... ..+...++++. T Consensus 294 ~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~ 368 (479) T 4UAD_A 294 SIRKEACWTISNITAGNRA-----QIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKP 368 (479) T ss_dssp HHHHHHHHHHHHHTTSCHH-----HHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHSCHHHHHHHHHTTCHHH T ss_pred HHHHHHHHHHHHHHcCCHH-----HHHHHHHCCHHHHHHHHHhccCHHHHHHHHHHHHHHHcCCCHHHHHHHHHcCcHHH Confidence 8888999999999865332 223334557888999999888889999999999999874 222 23344567788 Q NP_000290.2 640 VTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQ-----------YFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 640 Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~-----------Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) +..++.+ .++.++..++.+|.+++...+..... +.+.+.++.+..++.+. ++.++..++.+| T Consensus 369 l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~~-~~~v~~~a~~~l 441 (479) T 4UAD_A 369 LCDLLTV------MDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHE-NQEIYQKAFDLI 441 (479) T ss_dssp HHGGGGC------SCHHHHHHHHHHHHHHHHHHHHHTTTTSCCCCTTHHHHHHTTHHHHHHHGGGCS-CHHHHHHHHHHH T ss_pred HHHHhhc------CCHHHHHHHHHHHHHHHHHHHHhcccCCCCcCHHHHHHHHhchHHHHHHHHhCC-cHHHHHHHHHHH Confidence 8888776 36788889999999998753322111 34445677888888766 788999999999 Q NP_000290.2 709 SDMWSSKELQGVLRQ 723 (747) Q Consensus 709 snL~~~~~~~~~~~~ 723 (747) .+++...+....+.+ T Consensus 442 ~~l~~~~~~~~~~~~ 456 (479) T 4UAD_A 442 EHYFGVEDDDSSLAP 456 (479) T ss_dssp HHHSCC--------- T ss_pred HHhhCCCCCchhccc Confidence 999977665554443 No 21 >5ZHX_D Rap1 GTPase-GDP dissociation stimulator 1; armadillo GEF chaperone, ONCOPROTEIN; HET: FAR; 3.5A {Homo sapiens} Probab=98.39 E-value=6.3e-11 Score=120.93 Aligned_cols=407 Identities=17% Similarity=0.217 Sum_probs=228.2 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP--NQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~--d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) +++.+...+.+.++.++..++.++..++...+.....+...++++.+..++... ++.++..++.++..++.... ... T Consensus 19 ~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~v~~~a~~~l~~l~~~~~-~~~ 97 (487) T 5ZHX_D 19 LISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELES-SKE 97 (487) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHTTSTTCHHHHHHHHHTTCHHHHHHHHHHTSSCSHHHHHHHHHHHHHTTSSH-HHH T ss_pred cHHHHHHHHcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHHcccCCCHHHHHHHHHHHHHHHcchh-HHH Confidence 556677777777888999999999998875544444444556778888888765 77888899999998876532 222 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) .+...++++.+...+....++.++..++.++..++........+.. ++++.|..++....... .....+. T Consensus 98 ~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~---------~~~~~~~ 168 (487) T 5ZHX_D 98 QFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSD---------KEDDITE 168 (487) T ss_dssp HHHHTTHHHHHHHHHHHCCSHHHHHHHHHHHHHHHTSHHHHHHHHHHTHHHHHHHHHHHTSSCC---------CHHHHHH T ss_pred HHhhCCHHHHHHHHHHhccChHHHHHHHHHHHHHhcCHHHHHHHHHCCHHHHHHHHHHhcCCCC---------CHHHHHH Confidence 3334467777888776222677888899999998876444444444 67777777776432100 0000000 Q NP_000290.2 403 FFNATGCLR----------KRL------GMRELLALVPQ-------RATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQ 459 (747) Q Consensus 403 ~~~~~~~~~----------~~~------~~~~~~~~~~~-------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 459 (747) +..+...+. +-+ -+..++.+... .+...-.+++..+..+..+.. .+.++.+...+. T Consensus 169 l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~ 247 (487) T 5ZHX_D 169 LKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVD-NGIVEKLMDLLD 247 (487) T ss_dssp HHHHHHHHHHHTTSHHHHHHHSSSSSSSHHHHHHTTTTSSCHHHHHHHHHHHHHHCCSHHHHHHHHT-TTHHHHHHHHHH T ss_pred HHHHHHHHHHHHhccHHHHHHhhCCCchHHHHHHHHccCCCHHHHHHHHHHHHHHHcCchHHHHHHh-cCHHHHHHHHHH Confidence 000000000 000 00111111100 000000011111111111000 011222211111 Q NP_000290.2 460 NCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKG 539 (747) Q Consensus 460 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~ 539 (747) .... .-+..-...+..+|.|+. .. . .. T Consensus 248 ~~~~--~~~~~~~~~a~~~l~~l~-----------------------------------~~---------------~-~~ 274 (487) T 5ZHX_D 248 RHVE--DGNVTVQHAALSALRNLA-----------------------------------IP---------------V-IN 274 (487) T ss_dssp HTSS--SSCHHHHHHHHHHHHHHT-----------------------------------CS---------------H-HH T ss_pred hccc--CCCHHHHHHHHHHHHHhc-----------------------------------CC---------------h-hh Confidence 0000 000000111111111111 00 0 01 Q NP_000290.2 540 SGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNS-DVVRSGASL 618 (747) Q Consensus 540 ~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~-eVr~~AL~a 618 (747) ...+.+.++++.++.++. +.++.++..++++|.+++...+. . ........++++.++.++.+.+. .++..++++ T Consensus 275 ~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~---~-~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~ 349 (487) T 5ZHX_D 275 KAKMLSAGVTEAVLKFLK-SEMPPVQFKLLGTLRMLIDAQAE---A-AEQLGKNVKLVERLVEWCEAKDHAGVMGESNRL 349 (487) T ss_dssp HHHHHHHTHHHHHHTTSS-CCCHHHHHHHHHHHHHHTSSCHH---H-HHHHHHCHHHHHHHHHHHTCCSCCHHHHHHHHH T ss_pred HHHHHHcChHHHHHHHHh-CCCHHHHHHHHHHHHHHHhhcHH---H-HHHhccccCHHHHHHHHHHhcCchhhHHHHHHH Confidence 122345678888888888 46788888999999999875332 1 11221224678888888887665 888999999 Q NP_000290.2 619 LSNMSRHPL---L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP-QLAKQYFSSSMLNNIINLCR 693 (747) Q Consensus 619 LsnLa~~~e---~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~-e~~~~Lve~giL~~Ll~LL~ 693 (747) |.+++.... . ..+...++++.+..++.. .++.++..++.+|.+++...+ .....+.+.++++.++.++. T Consensus 350 l~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 423 (487) T 5ZHX_D 350 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATS------EHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRLLA 423 (487) T ss_dssp HHHHHHHHCCHHHHHHHHHHTCHHHHHHHTTC------SSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHHHHHHHHTS T ss_pred HHHHHHHhcchhHHHHHHHcchHHHHHHHhcC------CCHHHHHHHHHHHHHHHHcCCCchHHHHhhhhHHHHHHHHHh Confidence 999986522 2 233445677888888776 367889999999999987542 23333444457888888887 Q NP_000290.2 694 SS-ASPKAAEAARLLLSDMWSSKELQGVLRQQGFD 727 (747) Q Consensus 694 s~-~d~eVr~aAL~aLsnL~~~~~~~~~~~~~~~~ 727 (747) .. .++.++..++.+|.+++...+....+...|+- T Consensus 424 ~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~ 458 (487) T 5ZHX_D 424 DERSAPEIKYNSMVLICALMGSECLHKEVQDLAFL 458 (487) T ss_dssp SSCCSTTCTHHHHHHHHTSCSSSCCSTTTTTHHHH T ss_pred cccCcHHHHHHHHHHHHHHhCcHHHHHHHHHhchH Confidence 32 15788999999999999887766666555543 No 22 >1EE4_A KARYOPHERIN ALPHA; ARM repeat, TRANSPORT PROTEIN; 2.1A {Saccharomyces cerevisiae} SCOP: a.118.1.1 Probab=98.36 E-value=8.2e-11 Score=117.69 Aligned_cols=364 Identities=16% Similarity=0.224 Sum_probs=221.8 Template_Neff=13.200 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLRSPN-QNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~s~d-~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) ++.+...+.+.++.++..++..+..++..... ....+...++++.+...+...+ +.++..++.++..++......... T Consensus 3 ~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 82 (423) T 1EE4_A 3 LPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKV 82 (423) T ss_dssp HHHHHHHHTCSCHHHHHHHHHHHHHHHCCSSSCSHHHHHHTTCHHHHHHTTSTTSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred hHHHHHHhccccHHHHHHHHHHHHHHHhCCCCCchHHHHhcChHHHHHHHhhcCCcHHHHHHHHHHHHHHhCCCHHHHHH Confidence 44566666777788888888888888754321 2222333456777777776543 667888899998887644333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.|..++... ++++ T Consensus 83 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~ 145 (423) T 1EE4_A 83 VVDADAVPLFIQLLY-TGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSN----------------KPSL 145 (423) T ss_dssp HHHTTHHHHHHHHHH-HSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHHTTSC----------------CHHH T ss_pred HHhCChHHHHHHHHh-CCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHHhcC----------------CHHH Confidence 333456777777776 5677888899999998886532 2223333 6667776666421 2344 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) -..+..++..-... ...........+++..|...+.. .+......+...|.++ T Consensus 146 ~~~a~~~l~~l~~~---------------------~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l 198 (423) T 1EE4_A 146 IRTATWTLSNLCRG---------------------KKPQPDWSVVSQALPTLAKLIYS------MDTETLVDACWAISYL 198 (423) T ss_dssp HHHHHHHHHHHHCC---------------------STTCCCHHHHGGGHHHHHHHTTC------SCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHcC---------------------CCCCCChHHHhhHHHHHHHHHHc------CCHHHHHHHHHHHHHH Confidence 44444443321100 00000111122334433333221 1111112222222222 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) ... +......+.+.++++.+..++. +.++ T Consensus 199 ~~~--------------------------------------------------~~~~~~~~~~~~~~~~l~~~l~-~~~~ 227 (423) T 1EE4_A 199 SDG--------------------------------------------------PQEAIQAVIDVRIPKRLVELLS-HEST 227 (423) T ss_dssp TSS--------------------------------------------------CHHHHHHHHHTTHHHHHHHHTT-CSCH T ss_pred hcC--------------------------------------------------CHHHHHHHHhcCHHHHHHHHhc-CCCc Confidence 110 0001112234567778888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFPEV 640 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~~L 640 (747) .++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++.. +.. ..+...++++.+ T Consensus 228 ~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l 302 (423) T 1EE4_A 228 LVQTPALRAVGNIVTGNDL-----QTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPL 302 (423) T ss_dssp HHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHH T ss_pred chhHHHHHHHHHHHhCChH-----HHHHHHHcChHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHH Confidence 8888999999998865332 122333457888888888888888999999999999875 222 334455677888 Q NP_000290.2 641 TRLLTSHTGNTSNSEDILSSACYTVRNLMASQ---PQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKEL 717 (747) Q Consensus 641 l~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s---~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~~ 717 (747) ..++.+ .++.++..++.+|.+++... +.....+.+.++++.+..++.+. ++.++..++.+|.+++...+. T Consensus 303 ~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~a~~~l~~l~~~~~~ 375 (423) T 1EE4_A 303 VKLLEV------AEDKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIA-DNRIIEVTLDALENILKMGEA 375 (423) T ss_dssp HHHHHH------SCHHHHHHHHHHHHHHHGGGGTCHHHHHHHHHTTCHHHHHHGGGSS-CHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHhc------CCHHHHHHHHHHHHHHHcCCCCcHHHHHHHHHCCCHHHHHHHHhcC-CHHHHHHHHHHHHHHHHHHHH Confidence 888766 36788999999999998753 23334444456788888888876 788999999999999876554 No 23 >1EE4_B KARYOPHERIN ALPHA; ARM repeat, TRANSPORT PROTEIN; 2.1A {Saccharomyces cerevisiae} SCOP: a.118.1.1 Probab=98.36 E-value=8.2e-11 Score=117.69 Aligned_cols=364 Identities=16% Similarity=0.224 Sum_probs=221.8 Template_Neff=13.200 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLRSPN-QNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~s~d-~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) ++.+...+.+.++.++..++..+..++..... ....+...++++.+...+...+ +.++..++.++..++......... T Consensus 3 ~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 82 (423) T 1EE4_B 3 LPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKV 82 (423) T ss_dssp HHHHHHHHTSSCHHHHHHHHHHHHHHHCCSSSCCHHHHHHTTCHHHHHHTTSTTSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred hHHHHHHhccccHHHHHHHHHHHHHHHhCCCCCchHHHHhcChHHHHHHHhhcCCcHHHHHHHHHHHHHHhCCCHHHHHH Confidence 44566666777788888888888888754321 2222333456777777776543 667888899998887644333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.|..++... ++++ T Consensus 83 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~ 145 (423) T 1EE4_B 83 VVDADAVPLFIQLLY-TGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSN----------------KPSL 145 (423) T ss_dssp HHHTTHHHHHHHHHH-HSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHGGGSC----------------CHHH T ss_pred HHhCChHHHHHHHHh-CCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHHhcC----------------CHHH Confidence 333456777777776 5677888899999998886532 2223333 6667776666421 2344 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) -..+..++..-... ...........+++..|...+.. .+......+...|.++ T Consensus 146 ~~~a~~~l~~l~~~---------------------~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l 198 (423) T 1EE4_B 146 IRTATWTLSNLCRG---------------------KKPQPDWSVVSQALPTLAKLIYS------MDTETLVDACWAISYL 198 (423) T ss_dssp HHHHHHHHHHHHCC---------------------SSSCCCHHHHGGGHHHHHHHTTC------SCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHcC---------------------CCCCCChHHHhhHHHHHHHHHHc------CCHHHHHHHHHHHHHH Confidence 44444443321100 00000111122334433333221 1111112222222222 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) ... +......+.+.++++.+..++. +.++ T Consensus 199 ~~~--------------------------------------------------~~~~~~~~~~~~~~~~l~~~l~-~~~~ 227 (423) T 1EE4_B 199 SDG--------------------------------------------------PQEAIQAVIDVRIPKRLVELLS-HEST 227 (423) T ss_dssp HSS--------------------------------------------------CHHHHHHHHHTTHHHHHHHHTT-CSCH T ss_pred hcC--------------------------------------------------CHHHHHHHHhcCHHHHHHHHhc-CCCc Confidence 110 0001112234567778888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFPEV 640 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~~L 640 (747) .++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++.. +.. ..+...++++.+ T Consensus 228 ~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l 302 (423) T 1EE4_B 228 LVQTPALRAVGNIVTGNDL-----QTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPL 302 (423) T ss_dssp HHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHH T ss_pred chhHHHHHHHHHHHhCChH-----HHHHHHHcChHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHH Confidence 8888999999998865332 122333457888888888888888999999999999875 222 334455677888 Q NP_000290.2 641 TRLLTSHTGNTSNSEDILSSACYTVRNLMASQ---PQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKEL 717 (747) Q Consensus 641 l~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s---~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~~ 717 (747) ..++.+ .++.++..++.+|.+++... +.....+.+.++++.+..++.+. ++.++..++.+|.+++...+. T Consensus 303 ~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~a~~~l~~l~~~~~~ 375 (423) T 1EE4_B 303 VKLLEV------AEDKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIA-DNRIIEVTLDALENILKMGEA 375 (423) T ss_dssp HHHHHH------SCHHHHHHHHHHHHHHHGGGGTCTHHHHHHHHTTCHHHHHHGGGSS-CHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHhc------CCHHHHHHHHHHHHHHHcCCCCcHHHHHHHHHCCCHHHHHHHHhcC-CHHHHHHHHHHHHHHHHHHHH Confidence 888766 36788999999999998753 23334444456788888888876 788999999999999876554 No 24 >4EV8_A Catenin beta-1; mouse catenin, CELL ADHESION; HET: URE; 1.9A {Mus musculus} Probab=98.34 E-value=9.8e-11 Score=121.45 Aligned_cols=382 Identities=19% Similarity=0.227 Sum_probs=226.5 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..++.........+...++++.+...+.+.+..++..++.++..++.........+ T Consensus 103 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 182 (538) T 4EV8_A 103 GIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLII 182 (538) T ss_pred cHHHHHHHhCCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 45556666666677888889999988876543333333345677788888877778888999999998886444333334 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFF 404 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~ 404 (747) ...++++.+...+....+..++..++.++..+.........+.. ++++.+..++... ++++.. T Consensus 183 ~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~~~ 246 (538) T 4EV8_A 183 LASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDP----------------SQRLVQ 246 (538) T ss_pred HHCChHHHHHHHHcCCCCHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHhcCC----------------CHHHHH Confidence 44457777777776333567788888888888765444333433 6667777666432 233333 Q NP_000290.2 405 NATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSY 484 (747) Q Consensus 405 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 484 (747) .+..++..-.. .......+ .+.+..+...+.. .+..-...+...|.++.. T Consensus 247 ~a~~~l~~l~~---------------------~~~~~~~~---~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~ 296 (538) T 4EV8_A 247 NCLWTLRNLSD---------------------AATKQEGM---EGLLGTLVQLLGS------DDINVVTCAAGILSNLTC 296 (538) T ss_pred HHHHHHHHHHc---------------------CCCchHHH---cCcHHHHHHHhcC------CCHHHHHHHHHHHHHHHc Confidence 33333322110 00000001 2333333333321 111112222222333221 Q NP_000290.2 485 RLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK-SKKDA 563 (747) Q Consensus 485 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s-s~d~e 563 (747) .- ......+.+.++++.++..+.. ..++. T Consensus 297 ~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~~~~~~~~ 326 (538) T 4EV8_A 297 NN--------------------------------------------------YKNKMMVCQVGGIEALVRTVLRAGDRED 326 (538) T ss_pred CC--------------------------------------------------HHHHHHHHHCCcHHHHHHHHhcCCCCHH Confidence 00 0011122455677777776652 14566 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVT 641 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll 641 (747) ++..++.+|.+++..... .......+...++++.|..++.+. +..++..++.+|.+++..... ..+...++++.+. T Consensus 327 ~~~~a~~~l~~l~~~~~~--~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~ 404 (538) T 4EV8_A 327 ITEPAICALRHLTSRHQE--AEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLV 404 (538) T ss_pred HHHHHHHHHHHHHcCCCC--hHHHHHHHHHCCHHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCHHHHHHHHHCChHHHHH Confidence 778899999998865331 000012223457788888888765 678889999999999876433 3344556778888 Q NP_000290.2 642 RLLTSHTGNT----------------SNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 642 ~LL~s~s~~~----------------~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .++....... ...+.++..++.+|.+++.. ......+...++++.++.++.+. ++.++..++ T Consensus 405 ~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~-~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~a~ 482 (538) T 4EV8_A 405 QLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARD-VHNRIVIRGLNTIPLFVQLLYSP-IENIQRVAA 482 (538) T ss_pred HHHcCCCcchhhhhccCchHHHHHhcCCCHHHHHHHHHHHHHHhCC-cchhHHHHHcChHHHHHHHhcCC-CHHHHHHHH Confidence 7776521000 00156677899999999875 33344445556788888888876 788999999 Q NP_000290.2 706 LLLSDMWSSKELQGVLRQQGFD 727 (747) Q Consensus 706 ~aLsnL~~~~~~~~~~~~~~~~ 727 (747) .+|.+++...+....+.+.|+- T Consensus 483 ~~l~~l~~~~~~~~~~~~~~~~ 504 (538) T 4EV8_A 483 GVLCELAQDKEAAEAIEAEGAT 504 (538) T ss_pred HHHHHHHcCHHHHHHHHHCCcH Confidence 9999999877665555544443 No 25 >4RXH_B Importin subunit alpha, Large T; ARM repeat, NLS, nuclear import; 1.7553A {Neurospora crassa} Probab=98.34 E-value=1.1e-10 Score=121.65 Aligned_cols=365 Identities=17% Similarity=0.175 Sum_probs=215.9 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..++.........+...++++.+...+.+.++.++..++.++..++.......... T Consensus 72 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~ 151 (495) T 4RXH_B 72 VVGRFVEFLRSPHTLVQFEAAWALTNIASGSATQTQVVIEAGAVPIFVELLGSPEPDVREQAVWALGNIAGDSPQCRDYV 151 (495) T ss_dssp CHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHhCCChHHHHHHHhCChHHHHHHHhcCCCHHHHHHHHHHHHHHHCCCHHHHHHH Confidence 45566666666777888889999988876543333333345677788888887778889999999998886533333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEE-LIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~-Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ...++++.+...+....++.++..++.++..++........ ... ++++.+..++..+ ++++- T Consensus 152 ~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~v~ 215 (495) T 4RXH_B 152 LSCGALRPLLTLLGDSRKLSMLRNATWTLSNFCRGKTPQPDWNTIAPALPVLAKLVYSL----------------DDEVL 215 (495) T ss_dssp HHTTCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCTTCCCHHHHTTHHHHHHHHTTCS----------------SHHHH T ss_pred HhCCcHHHHHHHhccccCHHHHHHHHHHHHHHhCCCCCCCcHHhhcCHHHHHHHHhhCC----------------CHHHH Confidence 33456777777775333567888889999988875422211 112 5666666666431 23333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-. .........---.+++..|...++. .+..-...+...|.++. T Consensus 216 ~~a~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 268 (495) T 4RXH_B 216 IDACWAISYLS---------------------DGSNDKIQAVIEAGIPRRLVELLMH------ASTSVQTPALRSVGNIV 268 (495) T ss_dssp HHHHHHHHHHT---------------------SSCHHHHHHHHHTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHh---------------------cCCHHHHHHHHHCChHHHHHHHHhc------CCccHHHHHHHHHHHHh Confidence 33333332110 0000000000011344444443321 01111122222222222 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ..- ......+.+.++++.++.++. +.++. T Consensus 269 ~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~~ 297 (495) T 4RXH_B 269 TGD--------------------------------------------------DVQTQVIINCGALPCLLSLLS-SNKDG 297 (495) T ss_dssp TSC--------------------------------------------------HHHHHHHHHTTHHHHHHHHTT-CSCHH T ss_pred cCC--------------------------------------------------HHHHHHHHhCCHHHHHHHHHh-CCCHH Confidence 100 001112234567778888887 46778 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP----LL-HRVMGNQVFP 638 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~----e~-~~ll~~giI~ 638 (747) ++..++.+|.+++..... ....+...++++.|..++.+.++.++..++.+|.+++... .. ..+...++++ T Consensus 298 v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~ 372 (495) T 4RXH_B 298 IRKEACWTISNITAGNSA-----QIQSVIDANIIPPLIHLLSHADLKTRKEACWAISNATSGGLQKPDQIRYLVAQGCIK 372 (495) T ss_dssp HHHHHHHHHHHHHTSCHH-----HHHHHHHTTCHHHHHHHHHSSCHHHHHHHHHHHHHTTTTTTTCTHHHHHHHHTTCHH T ss_pred HHHHHHHHHHHHHcCCHH-----HHHHHHHCCcHHHHHHHHhcCCHHHHHHHHHHHHHHHhcCCCCHHHHHHHHHCCCHH Confidence 888899999998764332 1223344578888888888778888889999999988752 11 2233446777 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL--------------AKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~--------------~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) .+..++.+ .++.++..++.+|.+++...... ...+.+.++++.|..++.+. ++.++..+ T Consensus 373 ~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~ll~~~-~~~v~~~a 445 (495) T 4RXH_B 373 PLCDLLAC------PDNKIIQVALDGLENILKVGELDKNAAGDGPDSINRYALFIEECGGMEKIHDCQTNA-NEEIYMKA 445 (495) T ss_dssp HHHHGGGC------SCHHHHHHHHHHHHHHHHHHHHHHHTC-----CCCHHHHHHHHTTHHHHHHHGGGCC-SSTTHHHH T ss_pred HHHHHhhC------CCHHHHHHHHHHHHHHHHHhhHccccCCCCCchHHHHHHHHHHccchHHHHHhhhcC-CHHHHHHH Confidence 77777766 36778888999999888753211 22333455677788888766 78899999 Q NP_000290.2 705 RLLLSDMWSSKE 716 (747) Q Consensus 705 L~aLsnL~~~~~ 716 (747) +.+|.+++...+ T Consensus 446 ~~~l~~l~~~~~ 457 (495) T 4RXH_B 446 YNIIEKYFSDED 457 (495) T ss_dssp HHHHHHHCC--- T ss_pred HHHHHHhcCccc Confidence 999999886544 No 26 >4BQK_A IMPORTIN SUBUNIT ALPHA-1A, T-DNA BORDER; TRANSPORT PROTEIN, HYDROLASE, NUCLEAR LOCALIZATION; HET: PEG; 1.997A {ORYZA SATIVA} Probab=98.32 E-value=1.2e-10 Score=118.46 Aligned_cols=366 Identities=17% Similarity=0.164 Sum_probs=217.0 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQD-EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd-~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+.+ +.++..++.++..++.........+...++++.+..++.+.+..++..++.++..++......... T Consensus 46 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 125 (456) T 4BQK_A 46 VVPRFVQFLTREDFPQLQFEAAWALTNIASGTSENTKVVIDHGAVPIFVKLLGSSSDDVREQAVWALGNVAGDSPKCRDL 125 (456) T ss_dssp CHHHHHHHTTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHH T ss_pred cHHHHHHHhccCcCHHHHHHHHHHHHHHhcCCHhHHHHHHhccHHHHHHHHhcCCCHHHHHHHHHHHHHHHCCCHHHHHH Confidence 4455566665543 778888899998887554443333444567778888887777888899999999887653333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) +...+.+..++..+....++.++..++.++..++........... ++++.|..++... ++++- T Consensus 126 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~~ 189 (456) T 4BQK_A 126 VLANGALLPLLAQLNEHTKLSMLRNATWTLSNFCRGKPQPSFEQTRPALPALARLIHSN----------------DEEVL 189 (456) T ss_dssp HHHTTCHHHHHHTCCTTCCHHHHHHHHHHHHHHHCSSSCCCHHHHTTHHHHHHHHTTCC----------------CHHHH T ss_pred HHHCCcHHHHHHHHhhCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHhcCC----------------CHHHH Confidence 333455666666665334567888888888888775433222222 5666666666431 23333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-.. ..+ ..++.. .-.+++..|...+.. .+..-...+...|.++. T Consensus 190 ~~a~~~l~~l~~------~~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 242 (456) T 4BQK_A 190 TDACWALSYLSD------GTN--------------DKIQAV-IEAGVCPRLVELLLH------PSPSVLIPALRTVGNIV 242 (456) T ss_dssp HHHHHHHHHHTS------SSH--------------HHHHHH-HHTTCHHHHHHHTTC------SCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHhc------CCh--------------HHHHHH-HHCChHHHHHHHHhC------CCHHHHHHHHHHHHHHH Confidence 333333322110 000 000000 012334444333321 11111222222222222 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ..- ......+.+.++++.++.++....++. T Consensus 243 ~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~~~~~~~ 272 (456) T 4BQK_A 243 TGD--------------------------------------------------DAQTQCIIDHQALPCLLSLLTQNLKKS 272 (456) T ss_dssp TSC--------------------------------------------------HHHHHHHHTTTHHHHHHHHHHSCCCHH T ss_pred cCC--------------------------------------------------HHHHHHHHHCChHHHHHHHHHcCCCHH Confidence 100 000112244567888888887322677 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH--PLL-HRVMGNQVFPEV 640 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~--~e~-~~ll~~giI~~L 640 (747) ++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. ... ..+...++++.+ T Consensus 273 ~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l 347 (456) T 4BQK_A 273 IKKEACWTISNITAGNKD-----QIQAVINAGIIGPLVNLLQTAEFDIKKEAAWAISNATSGGSHDQIKYLVSEGCIKPL 347 (456) T ss_dssp HHHHHHHHHHHHHTSCHH-----HHHHHHHHTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHTTCHHHH T ss_pred HHHHHHHHHHHHhcCCHH-----HHHHHHHCCcHHHHHHHhhcCCHHHHHHHHHHHHHHHcCCCHHHHHHHHHCCCHHHH Confidence 888999999999865332 233334567888899999888888999999999999875 222 233344677888 Q NP_000290.2 641 TRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL-----------AKQYFSSSMLNNIINLCRSSASPKAAEAARLLLS 709 (747) Q Consensus 641 l~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~-----------~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLs 709 (747) ..++.+ .++.++..++.+|.+++...+.. ...+.+.+.++.+..++.+. ++.++..++.+|. T Consensus 348 ~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~ll~~~-~~~v~~~a~~~l~ 420 (456) T 4BQK_A 348 CDLLIC------PDIRIVTVCLEGLENILKVGETDKTLAAGDVNVFSQMIDEAEGLEKIENLQSHD-NNEIYEKAVKILE 420 (456) T ss_dssp HHGGGS------SCHHHHHHHHHHHHHHHHHHHHHHHHTTCSCCHHHHHHHHTTHHHHHHHHTTCS-CHHHHHHHHHHHH T ss_pred HHHhhC------CChHHHHHHHHHHHHHHHHhhhchhccCCCCCHHHHHHHHcchHHHHHHHHcCC-CHHHHHHHHHHHH Confidence 888776 36788899999999998753321 11122245677788888766 7889999999999 Q NP_000290.2 710 DMWSSKE 716 (747) Q Consensus 710 nL~~~~~ 716 (747) +++...+ T Consensus 421 ~l~~~~~ 427 (456) T 4BQK_A 421 AYWMDEE 427 (456) T ss_dssp HHCC--- T ss_pred HHhcCcc Confidence 9887544 No 27 >6BW9_A Importin subunit alpha-3, Protein W; Complex, Hendra virus, Importin, Karyopherin; 1.6A {Homo sapiens} Probab=98.31 E-value=1.3e-10 Score=118.46 Aligned_cols=366 Identities=17% Similarity=0.199 Sum_probs=218.4 Template_Neff=12.900 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+. ..++.++..++.++..++.........+...++++.+...+.+.+..++..++.++..++......... T Consensus 53 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 132 (459) T 6BW9_A 53 ILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDY 132 (459) T ss_dssp HHHHHHHHTTCTTCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHHTTCHHHHHH T ss_pred hHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHhhCCHHHHHHHHhcCCChHHHHHHHHHHHHHHcCCHHHHHH Confidence 4555666665 456778888899998887654433333344567778888887777888999999999887654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEEL-I-ADALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~L-v-egiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...+++..+...+....+..++..++.++..++......... . .++++.+..++.. .++++ T Consensus 133 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~v 196 (459) T 6BW9_A 133 VISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHH----------------TDVNI 196 (459) T ss_dssp HHHTTCHHHHHHTCSTTSCHHHHHHHHHHHHHHHCCCSSCCCHHHHHHHHHHHHHHTTC----------------CCHHH T ss_pred HHHCCcHHHHHhccCCCCCHHHHHHHHHHHHHHhcCCCCCCCHHHHHHHHHHHHHHHhc----------------CCHHH Confidence 3334566777777653345567888888888887643321111 1 1566666666543 13344 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..++..-... .+ ...... -..+++..|...++. .+..-...++..|.++ T Consensus 197 ~~~a~~~l~~l~~~------~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l 249 (459) T 6BW9_A 197 LVDTVWALSYLTDA------GN--------------EQIQMV-IDSGIVPHLVPLLSH------QEVKVQTAALRAVGNI 249 (459) T ss_dssp HHHHHHHHHHHHTS------CH--------------HHHHHH-HHTTCHHHHGGGGGC------SSHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhhc------Ch--------------HHHHHH-HhCChHHHHHHHcCC------CCHHHHHHHHHHHHHH Confidence 44444333221100 00 000000 012334444333321 1111122223333333 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) ....+ .....+.+.++++.++.++. +.++ T Consensus 250 ~~~~~--------------------------------------------------~~~~~~~~~~~~~~l~~~l~-~~~~ 278 (459) T 6BW9_A 250 VTGTD--------------------------------------------------EQTQVVLNCDALSHFPALLT-HPKE 278 (459) T ss_dssp TTSCH--------------------------------------------------HHHHHHHTTTGGGGCHHHHT-CSCH T ss_pred HcCCH--------------------------------------------------HHHHHHhcccchhcHHHHhh-CCCH Confidence 21100 00111234467788888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGNQVFPE 639 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~giI~~ 639 (747) .++..++.+|.+++..... ....+...++++.|..++.+.++.++..++.+|.+++.. . .. ......++++. T Consensus 279 ~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~ 353 (459) T 6BW9_A 279 KINKEAVWFLSNITAGNQQ-----QVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPP 353 (459) T ss_dssp HHHHHHHHHHHHHHTSCHH-----HHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHTTCHHH T ss_pred HHHHHHHHHHHHHcCCCHH-----HHHHHHHCCHHHHHHHHHHhCCHHHHHHHHHHHHHHHHhCCHHHHHHHHHCCcHHH Confidence 8888999999999865332 223334557888888888888888999999999999864 2 21 23334467788 Q NP_000290.2 640 VTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA----KQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 640 Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~----~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) +..++.+ .++.++..++.+|.+++...+... ..+...++++.+..++.+. ++.++..++.+|.+++... T Consensus 354 l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~~~ 426 (459) T 6BW9_A 354 FCNLLTV------KDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHE-NEDIYKLAYEIIDQFFSSD 426 (459) T ss_dssp HHGGGGC------SCHHHHHHHHHHHHHHHHHCTTTHHHHHHHHHHTTHHHHHHHHTTCS-CHHHHHHHHHHHHHHSCC- T ss_pred HHHhcCC------CCHHHHHHHHHHHHHHHHHhHhhHHHHHHHHHHcCHHHHHHHHhcCC-CHHHHHHHHHHHHHHcCCC Confidence 8888776 367888999999999987533221 1233346778888888766 7889999999999998766 Q NP_000290.2 716 EL 717 (747) Q Consensus 716 ~~ 717 (747) +. T Consensus 427 ~~ 428 (459) T 6BW9_A 427 DI 428 (459) T ss_dssp -- T ss_pred CC Confidence 54 No 28 >1WA5_B GTP-BINDING NUCLEAR PROTEIN RAN, IMPORTIN; NUCLEAR TRANSPORT-COMPLEX, NUCLEAR TRANSPORT, EXPORTIN; HET: GTP; 2.0A {CANIS FAMILIARIS} SCOP: a.118.1.1 Probab=98.27 E-value=1.9e-10 Score=121.37 Aligned_cols=134 Identities=13% Similarity=0.098 Sum_probs=85.4 Template_Neff=12.300 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++.+++...+.....+...++++.+..++.+.+..++..++.++..++......... T Consensus 173 ~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 252 (530) T 1WA5_B 173 DAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDW 252 (530) T ss_dssp TCHHHHHHHHHHCCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHGGGSCCHHHHHHHHHHHHHHHCCSSSCCCH T ss_pred ChHHHHHHHHhCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCcHHHHHHHhhCCCHHHHHHHHHHHHHHHCCCCCCCCH Confidence 34556666676777888899999999988654433334444567778888887777888888999998887644222222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRV 379 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL 379 (747) ....++++.+..++. ..++.++..++.++..++.... ....+.. ++++.|+.++ T Consensus 253 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l 308 (530) T 1WA5_B 253 SVVSQALPTLAKLIY-SMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELL 308 (530) T ss_dssp HHHGGGHHHHHHHTT-CCCHHHHHHHHHHHHHHHSSCHHHHHHHHHTTCHHHHHHGG T ss_pred HHHhhHHHHHHHHHh-cCCHHHHHHHHHHHHHHcCCCHHHHHHHHhCCHHHHHHHHh Confidence 223456666777765 4566777778888887776422 2222222 4455555544 No 29 >5XGC_A Rap1 GTPase-GDP dissociation stimulator 1; armadillo GEF, ONCOPROTEIN; 2.1A {Homo sapiens} Probab=98.27 E-value=2e-10 Score=117.66 Aligned_cols=409 Identities=17% Similarity=0.214 Sum_probs=224.4 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRS--PNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s--~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) +++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.. .++.++..++.++..++.... ... T Consensus 35 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~-~~~ 113 (503) T 5XGC_A 35 LISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELES-SKE 113 (503) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHSCCCSHHHHHHHHHTTHHHHHHHHHHHTTTCHHHHHHHHHHHHHHTTSHH-HHH T ss_pred cHHHHHHHHcCCCHHHHHHHHHHHHHHHcCCchHHHHHHHCChHHHHHHHHhccCCCHHHHHHHHHHHHHHHccHH-HHH Confidence 55666777777778889999999999887543333344445677788888776 467888889999988876532 222 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) .+...++++.+...+....++.++..++.++..++........+.. ++++.++.++....... + ....+. T Consensus 114 ~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~--------~-~~~~~~ 184 (503) T 5XGC_A 114 QFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSD--------K-EDDITE 184 (503) T ss_dssp HHTTTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTSHHHHHHHHHTTHHHHHHHHHHHHTTCC--------C-HHHHHH T ss_pred HHhcCCHHHHHHHHHHhcCChhHHHHHHHHHHHHHcCHHHHHHHHHCCHHHHHHHHHHhcCCCC--------C-HHHHHH Confidence 2334466777777776222677888899999998876444444444 67777777776432100 0 000000 Q NP_000290.2 403 FFNATGCLRKRL----------------GMRELLALVPQR-------ATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQ 459 (747) Q Consensus 403 ~~~~~~~~~~~~----------------~~~~~~~~~~~~-------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 459 (747) +..+...+..-. -+..++.+.... +...-.+++..+..+..+.. .|.++.|+..+. T Consensus 185 l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~-~~~~~~l~~~l~ 263 (503) T 5XGC_A 185 LKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVD-NGIVEKLMDLLD 263 (503) T ss_dssp HHHHHHHHHHHTTSHHHHHHHHGGGTCHHHHHHHHHTTSSCHHHHHHHHHHHHHHCSSHHHHHHHHH-TTHHHHHHHHHH T ss_pred HHHHHHHHHHHHhCCchHHHHHhcCcccHHHHHHHHccCCCHHHHHHHHHHHHHHHCChhHHHHHHH-CCHHHHHHHHHH Confidence 000000000000 000111110000 00000011111111110000 011222221111 Q NP_000290.2 460 NCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKG 539 (747) Q Consensus 460 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~ 539 (747) .... .-+..-...++.+|.++. .. . .. T Consensus 264 ~~~~--~~~~~~~~~a~~~l~~l~-----------------------------------~~---------------~-~~ 290 (503) T 5XGC_A 264 RHVE--DGNVTVQHAALSALRNLA-----------------------------------IP---------------V-IN 290 (503) T ss_dssp TTTT--TCCHHHHHHHHHHHHHHT-----------------------------------CS---------------H-HH T ss_pred hccc--cCCHHHHHHHHHHHHHhc-----------------------------------CC---------------H-HH Confidence 1000 000000011111111111 00 0 01 Q NP_000290.2 540 SGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNS-DVVRSGASL 618 (747) Q Consensus 540 ~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~-eVr~~AL~a 618 (747) ...+.+.++++.|..++. +.++.++..++.+|.+++...+. . ........++++.+..++.+.+. .++..++++ T Consensus 291 ~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~---~-~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~ 365 (503) T 5XGC_A 291 KAKMLSAGVTEAVLKFLK-SEMPPVQFKLLGTLRMLIDAQAE---A-AEQLGKNVKLVERLVEWCEAKDHAGVMGESNRL 365 (503) T ss_dssp HHHHHHHTHHHHHHTTTT-CCCHHHHHHHHHHHHHHTTTCHH---H-HHHHHTCHHHHHHHHHHHTCTTCHHHHHHHHHH T ss_pred HHHHHHcCHHHHHHHHHc-CCCHHHHHHHHHHHHHHHccCHH---H-HHHHccccchHHHHHHHHccCCccchHHHHHHH Confidence 122345678888888888 46778888999999999875332 0 11221235678888888877665 888999999 Q NP_000290.2 619 LSNMSRHPL---L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP-QLAKQYFSSSMLNNIINLCR 693 (747) Q Consensus 619 LsnLa~~~e---~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~-e~~~~Lve~giL~~Ll~LL~ 693 (747) |.+++.... . ..+...++++.+..++.+ .++.++..++.+|.+++...+ .....+...++++.+...+. T Consensus 366 l~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 439 (503) T 5XGC_A 366 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATS------EHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRLLA 439 (503) T ss_dssp HHHHHHHHCCHHHHHHHHHHTHHHHHHHHTTC------SSHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTHHHHHHHC-- T ss_pred HHHHHHHccChhHHHHHHhcChHHHHHHHhcC------CCHHHHHHHHHHHHHHHhCCCCcHHHHHHhccHHHHHHHHHh Confidence 999976522 2 233455677888888876 367889999999999987542 22333444457888888887 Q NP_000290.2 694 SS-ASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRN 729 (747) Q Consensus 694 s~-~d~eVr~aAL~aLsnL~~~~~~~~~~~~~~~~~~ 729 (747) .. .++.++..++.+|.+++...+....+...|+..- T Consensus 440 ~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~ 476 (503) T 5XGC_A 440 DERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDV 476 (503) T ss_dssp -----CGGGGHHHHHHHHHTTCSSCCCSGGGTHHHHH T ss_pred CCCCcHHHHHHHHHHHHHHhCCHHHHHHHHHhcHHHH Confidence 32 1578899999999999988776666655555443 No 30 >4BPL_A IMPORTIN SUBUNIT ALPHA-1A, NUCLEOPLASMIN NLS; TRANSPORT PROTEIN, NUCLEAR IMPORT, NUCLEAR; 2.3A {ORYZA SATIVA} Probab=98.24 E-value=2.4e-10 Score=115.88 Aligned_cols=367 Identities=17% Similarity=0.164 Sum_probs=216.2 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQD-EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd-~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+...+ +.++..++.++..++.........+...++++.+..++.+.++.++..++.++..++......... T Consensus 44 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 123 (454) T 4BPL_A 44 VVPRFVQFLTREDFPQLQFEAAWALTNIASGTSENTKVVIDHGAVPIFVKLLGSSSDDVREQAVWALGNVAGDSPKCRDL 123 (454) T ss_dssp CHHHHHHHHSCTTCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHHHSCHHHHHH T ss_pred cHHHHHHHhccCcCHHHHHHHHHHHHHHhcCChhhhHHHhhccHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 4455566665543 778888889998887544433333444567778888887777888999999999887653333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) +...+.+..++..+....++.++..++.++..++........... ++++.|..++.. -++++. T Consensus 124 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~~~ 187 (454) T 4BPL_A 124 VLANGALLPLLAQLNEHTKLSMLRNATWTLSNFCRGKPQPSFEQTRPALPALARLIHS----------------NDEEVL 187 (454) T ss_dssp HHHTTCHHHHHHTCSTTCCHHHHHHHHHHHHHHHCSSSCCCHHHHTTHHHHHHHHTTC----------------CCHHHH T ss_pred HHHCCcHHHHHHHHccCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHhC----------------CCHHHH Confidence 333455666666665334567888888888888765433222222 566666666542 123444 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-... .+ ..++.. -..+++..|...++. .+..-...+...|.++. T Consensus 188 ~~a~~~l~~l~~~------~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 240 (454) T 4BPL_A 188 TDACWALSYLSDG------TN--------------DKIQAV-IEAGVCPRLVELLLH------PSPSVLIPALRTVGNIV 240 (454) T ss_dssp HHHHHHHHHHTSS------CH--------------HHHHHH-HHTTCHHHHHHHTTC------SCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHhcC------Ch--------------HHHHHH-HHCCcHHHHHHHhhC------CChHHHHHHHHHHHHHh Confidence 4444333221100 00 000000 012334444333321 01111122222222221 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) .. +......+.+.++++.++.++....++. T Consensus 241 ~~--------------------------------------------------~~~~~~~~~~~~~~~~l~~~l~~~~~~~ 270 (454) T 4BPL_A 241 TG--------------------------------------------------DDAQTQCIIDHQALPCLLSLLTQNLKKS 270 (454) T ss_dssp TS--------------------------------------------------CHHHHHHHHTTTHHHHHHHHHHSSCCHH T ss_pred cC--------------------------------------------------CHHHHHHHHHCChHHHHHHHHHhcCCHH Confidence 10 0001112234567888888887322677 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH--PLL-HRVMGNQVFPEV 640 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~--~e~-~~ll~~giI~~L 640 (747) ++..++.+|.+++..... ....+...++++.|..++.+.++.++..++.+|.+++.. ... ..+...++++.+ T Consensus 271 ~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l 345 (454) T 4BPL_A 271 IKKEACWTISNITAGNKD-----QIQAVINAGIIGPLVNLLQTAEFDIKKEAAWAISNATSGGSHDQIKYLVSEGCIKPL 345 (454) T ss_dssp HHHHHHHHHHHHHTSCHH-----HHHHHHHHTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHTTCHHHH T ss_pred HHHHHHHHHHHHhcCCHH-----HHHHHHhCCcHHHHHHHhhcCCHHHHHHHHHHHHHHHcCCCHHHHHHHHHCCCHHHH Confidence 888999999999865332 233334567888899999888888999999999999875 222 233444677888 Q NP_000290.2 641 TRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA-----------KQYFSSSMLNNIINLCRSSASPKAAEAARLLLS 709 (747) Q Consensus 641 l~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~-----------~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLs 709 (747) ..++.+ .++.++..++.+|.+++....... ..+.+.+.++.+..++.+. ++.++..++.+|. T Consensus 346 ~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~ 418 (454) T 4BPL_A 346 CDLLIC------PDIRIVTVCLEGLENILKVGETDKTLAAGDVNVFSQMIDEAEGLEKIENLQSHD-NNEIYEKAVKILE 418 (454) T ss_dssp HHTTTC------SCHHHHHHHHHHHHHHHHHHHHHHHHHTCSSCHHHHHHHHTTHHHHHHHGGGCS-CHHHHHHHHHHHH T ss_pred HHHhcC------CChHHHHHHHHHHHHHHHHhhhchhcccCCCCHHHHHHHHcccHHHHHHHHcCC-CHHHHHHHHHHHH Confidence 888776 367888899999999987532211 1112245677788888766 7889999999999 Q NP_000290.2 710 DMWSSKEL 717 (747) Q Consensus 710 nL~~~~~~ 717 (747) .+....+. T Consensus 419 ~l~~~~~~ 426 (454) T 4BPL_A 419 AYWMDEED 426 (454) T ss_dssp HHCC---- T ss_pred HHhcCccc Confidence 99876544 No 31 >4B8J_A IMPORTIN SUBUNIT ALPHA-1A; TRANSPORT PROTEIN, NUCLEAR LOCALIZATION SIGNAL; 2.001A {ORYZA SATIVA JAPONICA GROUP} Probab=98.24 E-value=2.6e-10 Score=119.98 Aligned_cols=367 Identities=17% Similarity=0.160 Sum_probs=217.7 Template_Neff=12.400 Q NP_000290.2 246 TIPKAVQYLSSQD-EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd-~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+.+ +.++..++.+|..++.........+...++++.+..++.+.+..++..++.+|..++......... T Consensus 118 ~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 197 (528) T 4B8J_A 118 VVPRFVQFLTREDFPQLQFEAAWALTNIASGTSENTKVVIDHGAVPIFVKLLGSSSDDVREQAVWALGNVAGDSPKCRDL 197 (528) T ss_dssp CHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHHTCHHHHHH T ss_pred cHHHHHHHhcCCCCHHHHHHHHHHHHHHHcCChHHHHHHHhCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 4555666665544 778888999998887544433333444557778888887777888899999999887654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) +...+++..++..+....++.++..++.++..++........... ++++.|..++.. .++++. T Consensus 198 ~~~~~~l~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~v~ 261 (528) T 4B8J_A 198 VLANGALLPLLAQLNEHTKLSMLRNATWTLSNFCRGKPQPSFEQTRPALPALARLIHS----------------NDEEVL 261 (528) T ss_dssp HHHTTCHHHHHHTCCTTCCHHHHHHHHHHHHHHHCSSSCCCHHHHTTHHHHHHHHTTC----------------CCHHHH T ss_pred HHHCCcHHHHHHHHccCCCHHHHHHHHHHHHHHhCCCCCCCHHHHhhHHHHHHHHhcC----------------CCHHHH Confidence 333455666666664334567888888999888875433222222 566666666643 133444 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..+|..-.. ..+ ...+.+ ...++++.|+..++. .+..-...+...|.++. T Consensus 262 ~~a~~~l~~l~~------~~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 314 (528) T 4B8J_A 262 TDACWALSYLSD------GTN--------------DKIQAV-IEAGVCPRLVELLLH------PSPSVLIPALRTVGNIV 314 (528) T ss_dssp HHHHHHHHHHTS------SCH--------------HHHHHH-HHTTCHHHHHHHTTC------SCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHhc------CCh--------------HHHHHH-HHCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHH Confidence 444443322110 000 000000 012344444433321 01111122222222222 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ..- ......+.+.++++.|+.++....++. T Consensus 315 ~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~~~~~~~ 344 (528) T 4B8J_A 315 TGD--------------------------------------------------DAQTQCIIDHQALPCLLSLLTQNLKKS 344 (528) T ss_dssp TSC--------------------------------------------------HHHHHHHHTTTHHHHHHHHHHSCCCHH T ss_pred cCC--------------------------------------------------HHHHHHHHHCChHHHHHHHHhcCCCHH Confidence 100 001112245567888888887322677 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGNQVFPEV 640 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~giI~~L 640 (747) ++..++.+|.+++..... ....+...++++.|..++.+.++.++..++.+|.+++.. . .. ..+...++++.| T Consensus 345 v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l 419 (528) T 4B8J_A 345 IKKEACWTISNITAGNKD-----QIQAVINAGIIGPLVNLLQTAEFDIKKEAAWAISNATSGGSHDQIKYLVSEGCIKPL 419 (528) T ss_dssp HHHHHHHHHHHHHTSCHH-----HHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHSCHHHHHHHHHTTCHHHH T ss_pred HHHHHHHHHHHHHcCCHH-----HHHHHHHCCchHHHHHHHhcCCHHHHHHHHHHHHHHHcCCCHHHHHHHHHCCCHHHH Confidence 888999999999865332 233334567888999999888888999999999999875 2 22 233344677888 Q NP_000290.2 641 TRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL-----------AKQYFSSSMLNNIINLCRSSASPKAAEAARLLLS 709 (747) Q Consensus 641 l~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~-----------~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLs 709 (747) ..++.+ .++.++..++.+|.+++...... ...+.+.++++.|..++.+. ++.++..|+.+|. T Consensus 420 ~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~ll~~~-~~~v~~~a~~~l~ 492 (528) T 4B8J_A 420 CDLLIC------PDIRIVTVCLEGLENILKVGETDKTLAAGDVNVFSQMIDEAEGLEKIENLQSHD-NNEIYEKAVKILE 492 (528) T ss_dssp HHGGGC------SCHHHHHHHHHHHHHHHHHHHHHHHHHTCSCCHHHHHHHHTTHHHHHHHGGGCS-SHHHHHHHHHHHH T ss_pred HHHccC------CCHHHHHHHHHHHHHHHHHhHHcHhhcCCCCcHHHHHHHHcCHHHHHHHHhcCC-CHHHHHHHHHHHH Confidence 888776 36788899999999998753221 11122345677788888766 7889999999999 Q NP_000290.2 710 DMWSSKEL 717 (747) Q Consensus 710 nL~~~~~~ 717 (747) +++...+. T Consensus 493 ~l~~~~~~ 500 (528) T 4B8J_A 493 AYWMDEED 500 (528) T ss_dssp HHCC---- T ss_pred Hhcccccc Confidence 98875544 No 32 >5T94_B Guanine nucleotide exchange factor SRM1; Nuclear Import, Importin alpha, RCC1; 2.631A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=98.23 E-value=2.9e-10 Score=120.53 Aligned_cols=364 Identities=15% Similarity=0.171 Sum_probs=219.0 Template_Neff=12.200 Q NP_000290.2 246 TIPKAVQYLSSQD-EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd-~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.++..+.+.+ +.++..++.+|..++.........+...++++.+...+.+.++.++..++.++..++......... T Consensus 131 ~~~~L~~~l~~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 210 (542) T 5T94_B 131 VVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDY 210 (542) T ss_dssp CHHHHHHTTSSSSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCHHHHHH T ss_pred hHHHHHHHhhcCCCHHHHHHHHHHHHHHHcCChHHHHHHhcCChHHHHHHHHhCCCHHHHHHHHHHHHHHHCCCHHHHHH Confidence 4555666665443 677888899998887654333333334567777888887777888999999999988654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...++++.+..++. ..++.++..++.+|..++.... ....... ++++.|+.++.. .++++ T Consensus 211 ~~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~~ 273 (542) T 5T94_B 211 VLQCNAMEPILGLFN-SNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYS----------------MDTET 273 (542) T ss_dssp HHHTTCHHHHHHGGG-CCCHHHHHHHHHHHHHHSCCSTTCCCHHHHGGGHHHHHHHTTC----------------CCHHH T ss_pred HHHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCCCCCCHHHHhcHHHHHHHHHhc----------------CCHHH Confidence 344467777777776 5567788889999998887542 2222222 566777766642 12334 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..+|..-... -+ ...+.+. -.+++..|...++. .+..-...+...|.++ T Consensus 274 ~~~a~~~L~~l~~~------~~--------------~~~~~~~-~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~l 326 (542) T 5T94_B 274 LVDACWAISYLSDG------PQ--------------EAIQAVI-DVRIPKRLVELLSH------ESTLVQTPALRAVGNI 326 (542) T ss_dssp HHHHHHHHHHHSSS------SH--------------HHHHHHH-HTTCHHHHHHTTSC------SSHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHcCC------CH--------------HHHHHHH-hCCHHHHHHHHhcC------CCHHHHHHHHHHHHHH Confidence 33333333221100 00 0000000 01233333322221 1111112222222222 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) ...- ......+.+.++++.|+.++. +.++ T Consensus 327 ~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~ 355 (542) T 5T94_B 327 VTGN--------------------------------------------------DLQTQVVINAGVLPALRLLLS-SPKE 355 (542) T ss_dssp TTSC--------------------------------------------------HHHHHHHHHTTHHHHHHHHTT-CSSH T ss_pred HcCC--------------------------------------------------HHHHHHHHHCChHHHHHHHhh-CCCH Confidence 2100 001111234567888888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL----L-HRVMGNQVF 637 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e----~-~~ll~~giI 637 (747) .++..++++|.+++...+. ....+...++++.|..++.+.++.++..++++|.+++.... . ..+...+++ T Consensus 356 ~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~ 430 (542) T 5T94_B 356 NIKKEACWTISNITAGNTE-----QIQAVIDANLIPPLVKLLEVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCI 430 (542) T ss_dssp HHHHHHHHHHHHHTTSCHH-----HHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHGGGTTCTHHHHHHHHTTCH T ss_pred HHHHHHHHHHHHHhCCCHH-----HHHHHHHCCchHHHHHHHHcCCHHHHHHHHHHHHHHHcCCCCCHHHHHHHHHCCCH Confidence 8888999999999875332 23333456788888888888888899999999999987621 1 223345678 Q NP_000290.2 638 PEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-----------LAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 638 ~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-----------~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) +.|..++.+ .++.++..++.+|.+++...+. ....+.+.++++.|..++.+. ++.++..|+. T Consensus 431 ~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~ll~~~-~~~v~~~a~~ 503 (542) T 5T94_B 431 KPLCDLLEI------ADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNE-NDKIYEKAYK 503 (542) T ss_dssp HHHHHHHHH------CCHHHHHHHHHHHHHHHHHHHHHTTTTTCSSCTTTHHHHHTTCHHHHHTTSSSC-CHHHHHHHHH T ss_pred HHHHHHhcC------CCHHHHHHHHHHHHHHHHHHHHHHHHcCCCccHHHHHHHHcCHHHHHHHHHhCC-CHHHHHHHHH Confidence 888888876 3677888999999999875332 123344456788888888766 7889999999 Q NP_000290.2 707 LLSDMWSSKE 716 (747) Q Consensus 707 aLsnL~~~~~ 716 (747) +|.+++...+ T Consensus 504 ~l~~l~~~~~ 513 (542) T 5T94_B 504 IIETYFGEEE 513 (542) T ss_dssp HHHHHC---- T ss_pred HHHHHhCcCc Confidence 9999987543 No 33 >4TNM_A Importin-alpha3 / MOS6; armadillo repeat; 2.9A {Arabidopsis thaliana} Probab=98.21 E-value=3.2e-10 Score=119.57 Aligned_cols=369 Identities=17% Similarity=0.184 Sum_probs=220.4 Template_Neff=12.300 Q NP_000290.2 246 TIPKAVQYLSSQD-EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd-~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+.+ +.++..++.++..++.........+...++++.+..++.+.++.++..++.++..++......... T Consensus 119 ~~~~l~~~l~~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 198 (531) T 4TNM_A 119 VVPRVVKFLSRDDFPKLQFEAAWALTNIASGTSENTNVIIESGAVPIFIQLLSSASEDVREQAVWALGNVAGDSPKCRDL 198 (531) T ss_pred CHHHHHHHhcCCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCCHHHHHHHccCCCHHHHHHHHHHHHHHhcCCHHHHHH Confidence 4555666665544 778888889998887644333333444567778888887777888999999999887653333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) +...+++..+...+....+..++..++.++..++........... ++++.|..++... ++++. T Consensus 199 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~v~ 262 (531) T 4TNM_A 199 VLSYGAMTPLLSQFNENTKLSMLRNATWTLSNFCRGKPPPAFEQTQPALPVLERLVQSM----------------DEEVL 262 (531) T ss_pred HHHCCCHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCCCCcchhhhcchHHHHHHHhcCC----------------CHHHH Confidence 333456666666664334567888888898888765433222222 5666666665431 33444 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..+|..-.. .+......-.-.+++..|...+.. .+..-...+...|.++. T Consensus 263 ~~a~~~l~~l~~---------------------~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~L~~l~ 315 (531) T 4TNM_A 263 TDACWALSYLSD---------------------NSNDKIQAVIEAGVVPRLIQLLGH------SSPSVLIPALRTIGNIV 315 (531) T ss_pred HHHHHHHHHHhC---------------------CCHHHHHHHHHCChHHHHHHHHhC------CCHHHHHHHHHHHHHHH Confidence 444433322110 000000000012334444333321 11112222233333322 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ...+ .....+.+.++++.|+.++....++. T Consensus 316 ~~~~--------------------------------------------------~~~~~~~~~~~~~~l~~~l~~~~~~~ 345 (531) T 4TNM_A 316 TGDD--------------------------------------------------LQTQMVLDQQALPCLLNLLKNNYKKS 345 (531) T ss_pred CCCH--------------------------------------------------HHHHHHHHCCcHHHHHHHhcCCCCHH Confidence 1100 00111234467788888887323567 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PL-L-HRVMGNQVFPEV 640 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e-~-~~ll~~giI~~L 640 (747) ++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++++|.+++.. .. . ..+...++++.| T Consensus 346 v~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l 420 (531) T 4TNM_A 346 IKKEACWTISNITAGNAD-----QIQAVIDAGIIQSLVWVLQSAEFEVKKEAAWGISNATSGGTHDQIKFMVSQGCIKPL 420 (531) T ss_pred HHHHHHHHHHHHHCCCHH-----HHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHHHHHCCcHHHH Confidence 888999999999875332 233334566888888888887888999999999999875 21 2 233344677888 Q NP_000290.2 641 TRLLTSHTGNTSNSEDILSSACYTVRNLMASQ------------PQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 641 l~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s------------~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ..++.+ .++.++..++.+|.+++... ......+.+.++++.|..++.+. ++.++..|+.+| T Consensus 421 ~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~ll~~~-~~~v~~~a~~~l 493 (531) T 4TNM_A 421 CDLLTC------PDLKVVTVCLEALENILVVGEAEKNLGHTGEDNLYAQMIDEAEGLEKIENLQSHD-NNDIYDKAVKIL 493 (531) T ss_pred HHHccC------CCHHHHHHHHHHHHHHHhhCccchhhcCCCCcHHHHHHHHHCCcHHHHHHHhcCC-CHHHHHHHHHHH Confidence 888776 36788899999999998531 11223334446788888888776 788999999999 Q NP_000290.2 709 SDMWSSKELQG 719 (747) Q Consensus 709 snL~~~~~~~~ 719 (747) .+++...+... T Consensus 494 ~~l~~~~~~~~ 504 (531) T 4TNM_A 494 ETFWTEDNEEE 504 (531) T ss_pred HHHhcCCCCcc Confidence 99987655443 No 34 >5TBK_C Importin subunit alpha-3, Regulator of; Nuclear Import, Importin alpha, RCC1; 3.45A {Homo sapiens} Probab=98.21 E-value=3.4e-10 Score=119.34 Aligned_cols=366 Identities=16% Similarity=0.161 Sum_probs=222.2 Template_Neff=12.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESA-KQQVYQLGGICKLVDLLRSP-NQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~-~~~li~~~IL~~Ll~lL~s~-d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .+++.+...+.+.++.++..++.+|..++...... ...+...++++.+...+... +..++..++.++..++....... T Consensus 71 ~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~ 150 (521) T 5TBK_C 71 TSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQT 150 (521) T ss_dssp CCSSTHHHHTTSSCHHHHHHHHHHHHHHHHTTTCCCTTSCTTTTHHHHHHHHHHCCSCHHHHHHHHHHHHHHHTSCHHHH T ss_pred hcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCCCCCHHHHHHCCcHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCChHHH Confidence 35566677777777788888999998887643221 12233346677777777643 67788888999988876543333 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDP 400 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~ 400 (747) ..+...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.|+.++... .++ T Consensus 151 ~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~~~ 214 (521) T 5TBK_C 151 QAVVQSNAVPLFLRLLH-SPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPS---------------IPI 214 (521) T ss_dssp HHHHTTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHHHHCHHHHHHHHHTTCHHHHHTTCCTT---------------SCH T ss_pred HHHHHCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHhCCC---------------CCH Confidence 33334457777777776 5567888899999999886432 2222333 6677777766532 123 Q NP_000290.2 401 EVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLH 480 (747) Q Consensus 401 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 480 (747) ++...+..+|..-. .............+++..|...+.. .+..-...+..+|. T Consensus 215 ~~~~~a~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~L~ 267 (521) T 5TBK_C 215 TFLRNVTWVMVNLC---------------------RHKDPPPPMETIQEILPALCVLIHH------TDVNILVDTVWALS 267 (521) T ss_dssp HHHHHHHHHHHHHH---------------------CCCSSCCCHHHHHHHHHHHHHHTTC------SCHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH---------------------cCCCCCCCHHHHHHHHHHHHHHhhC------CCHHHHHHHHHHHH Confidence 33333433332211 0000001111122333333333221 11222223333333 Q NP_000290.2 481 NLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSK 560 (747) Q Consensus 481 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~ 560 (747) ++...-+ .....+.+.++++.++.++. +. T Consensus 268 ~l~~~~~--------------------------------------------------~~~~~~~~~~~~~~l~~~l~-~~ 296 (521) T 5TBK_C 268 YLTDAGN--------------------------------------------------EQIQMVIDSGIVPHLVPLLS-HQ 296 (521) T ss_dssp HHHHHCH--------------------------------------------------HHHHHHHHTTCHHHHGGGGG-CS T ss_pred HHhccCh--------------------------------------------------HHHHHHHHCChHHHHHHHhc-CC Confidence 3321100 01112234567788888887 46 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVFP 638 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI~ 638 (747) ++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++++|.+++... .. ..+...++++ T Consensus 297 ~~~v~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~ 371 (521) T 5TBK_C 297 EVKVQTAALRAVGNIVTGTDE-----QTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVP 371 (521) T ss_dssp SHHHHHHHHHHHHHHHTSCHH-----HHHHHHHTTCGGGHHHHHTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHTTTCHH T ss_pred CHHHHHHHHHHHHHHHcCCHH-----HHHHHHhCCHHHhHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHH Confidence 677888899999998875332 2233344578888888888888889999999999998762 22 2334456778 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP-QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~-e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) .|..++.+ .++.++..++.+|.+++.... .....+.+.++++.|..++.+. ++.++..++.+|.+++...+ T Consensus 372 ~l~~~l~~------~~~~v~~~a~~~L~~l~~~~~~~~~~~l~~~~~~~~L~~~l~~~-~~~v~~~a~~~l~~l~~~~~ 443 (521) T 5TBK_C 372 MIIHLLDK------GDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVK-DAQVVQVVLDGLSNILKMAE 443 (521) T ss_dssp HHHHHHHH------SCHHHHHHHHHHHHHHHHHSCHHHHHHHHTTTCHHHHHGGGGSS-CHHHHHHHHHHHHHHHHHCS T ss_pred HHHHHHHh------CCHHHHHHHHHHHHHHHccCCHHHHHHHHHCCCHHHHHHHcCCC-CHHHHHHHHHHHHHHHHHhH Confidence 88888776 367788999999999985322 2233344456788888888766 77888999999999887543 No 35 >5TBK_D Importin subunit alpha-3, Regulator of; Nuclear Import, Importin alpha, RCC1; 3.45A {Homo sapiens} Probab=98.21 E-value=3.4e-10 Score=119.34 Aligned_cols=366 Identities=16% Similarity=0.161 Sum_probs=221.8 Template_Neff=12.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESA-KQQVYQLGGICKLVDLLRSP-NQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~-~~~li~~~IL~~Ll~lL~s~-d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .+++.+...+.+.++.++..++.+|..++...... ...+...++++.+...+... +..++..++.++..++....... T Consensus 71 ~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~ 150 (521) T 5TBK_D 71 TSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQT 150 (521) T ss_dssp -CCSHHHHHTTSSCHHHHHHHHHHHHTHHHHHHSSCSHHHHHHTHHHHHHHHHHCCSCHHHHHHHHHHHHHHHTSCHHHH T ss_pred hcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCCCCCHHHHHHCCcHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCChHHH Confidence 35566677777777788888999998887643221 12233346677777777643 67788888999988876543333 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDP 400 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~ 400 (747) ..+...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.|+.++... .++ T Consensus 151 ~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~~~ 214 (521) T 5TBK_D 151 QAVVQSNAVPLFLRLLH-SPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPS---------------IPI 214 (521) T ss_dssp HHHHTTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHHHHCHHHHHHHHHTCCHHHHHTTCCTT---------------SCH T ss_pred HHHHHCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHhCCC---------------CCH Confidence 33334457777777776 5567888899999999886432 2222333 6677777766532 123 Q NP_000290.2 401 EVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLH 480 (747) Q Consensus 401 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 480 (747) ++...+..+|..-. .............+++..|...+.. .+..-...+..+|. T Consensus 215 ~~~~~a~~~l~~l~---------------------~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~L~ 267 (521) T 5TBK_D 215 TFLRNVTWVMVNLC---------------------RHKDPPPPMETIQEILPALCVLIHH------TDVNILVDTVWALS 267 (521) T ss_dssp HHHHHHHHHHHHHH---------------------CCCSSCCCHHHHHHHHHHHHHHTTC------SCHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH---------------------cCCCCCCCHHHHHHHHHHHHHHhhC------CCHHHHHHHHHHHH Confidence 33333433332211 0000001111122333333333221 11222223333333 Q NP_000290.2 481 NLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSK 560 (747) Q Consensus 481 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~ 560 (747) ++...-+ .....+.+.++++.++.++. +. T Consensus 268 ~l~~~~~--------------------------------------------------~~~~~~~~~~~~~~l~~~l~-~~ 296 (521) T 5TBK_D 268 YLTDAGN--------------------------------------------------EQIQMVIDSGIVPHLVPLLS-HQ 296 (521) T ss_dssp HHHHHCH--------------------------------------------------HHHHHHHHTTCHHHHGGGGG-CS T ss_pred HHhccCh--------------------------------------------------HHHHHHHHCChHHHHHHHhc-CC Confidence 3321100 01112234567788888887 46 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVFP 638 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI~ 638 (747) ++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++++|.+++... .. ..+...++++ T Consensus 297 ~~~v~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~ 371 (521) T 5TBK_D 297 EVKVQTAALRAVGNIVTGTDE-----QTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVP 371 (521) T ss_dssp SHHHHHHHHHHHHHHHTSCHH-----HHHHHHHTTCGGGHHHHHHCSCHHHHHHHHHHHHHHTTSCHHHHHHHHTTTCHH T ss_pred CHHHHHHHHHHHHHHHcCCHH-----HHHHHHhCCHHHhHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHH Confidence 677888899999998875332 2233344578888888888888889999999999998762 22 2334456778 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP-QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~-e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) .|..++.+ .++.++..++.+|.+++.... .....+.+.++++.|..++.+. ++.++..++.+|.+++...+ T Consensus 372 ~l~~~l~~------~~~~v~~~a~~~L~~l~~~~~~~~~~~l~~~~~~~~L~~~l~~~-~~~v~~~a~~~l~~l~~~~~ 443 (521) T 5TBK_D 372 MIIHLLDK------GDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVK-DAQVVQVVLDGLSNILKMAE 443 (521) T ss_dssp HHHHHHHH------SCHHHHHHHHHHHHHHHHHSCHHHHHHHHTTTCHHHHHGGGGSS-CHHHHHHHHHHHHHHHHHCS T ss_pred HHHHHHHh------CCHHHHHHHHHHHHHHHccCCHHHHHHHHHCCCHHHHHHHcCCC-CHHHHHHHHHHHHHHHHHhH Confidence 88888776 367788999999999985322 2233344456788888888766 77888999999999887543 No 36 >2Z6G_A B-catenin; Full-Length, Beta-Catenin, CELL ADHESION; 3.4A {Danio rerio} Probab=98.14 E-value=6.4e-10 Score=126.67 Aligned_cols=381 Identities=19% Similarity=0.217 Sum_probs=223.9 Template_Neff=10.700 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+..++.+.+..++..++.+|.+++.........+...++++.+..++...+..++..++.+|..++......... T Consensus 234 ~~i~~L~~lL~~~~~~v~~~al~~L~~l~~~~~~~~~~~~~~~~~~~L~~lL~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 313 (780) T 2Z6G_A 234 GGIPALVNMLGSPVDSVLFHAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLI 313 (780) T ss_pred CcHHHHHHHhCCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 34566666776667788888999998887654333333333567777888887777888889999999888644433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) +...+++..++.++....+..++..++.+|..++........+.. ++++.|..++... ++++. T Consensus 314 ~~~~~~~~~L~~~l~~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~l~~L~~~l~~~----------------~~~v~ 377 (780) T 2Z6G_A 314 ILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDP----------------SQRLV 377 (780) T ss_pred HHHCCcHHHHHHHhCCCCCHHHHHHHHHHHHHHhCCHHHHHHHHHCCHHHHHHHHccCC----------------CHHHH Confidence 333456777777776223567788888888888765443333333 6677777666531 23343 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..+|+.-.. ...... ...+++..|...+.. .+..-...+..+|.++. T Consensus 378 ~~al~~L~~l~~---------------------~~~~~~---~~~~~l~~L~~~l~~------~~~~v~~~a~~~L~~l~ 427 (780) T 2Z6G_A 378 QNCLWTLRNLSD---------------------AATKQE---GMEGLLGTLVQLLGS------DDINVVTCAAGILSNLT 427 (780) T ss_pred HHHHHHHHHHhc---------------------CCCCHH---HHcChHHHHHHHhcC------CCHHHHHHHHHHHHHHH Confidence 344433332110 000000 012333333333221 01111222222333322 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGK-SKKD 562 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~s-s~d~ 562 (747) ... ......+...++++.|+..+.. ..++ T Consensus 428 ~~~--------------------------------------------------~~~~~~~~~~~~l~~L~~~l~~~~~~~ 457 (780) T 2Z6G_A 428 CNN--------------------------------------------------YKNKMMVCQVGGIEALVRTVLRAGDRE 457 (780) T ss_pred cCC--------------------------------------------------HHHHHHHHHCChHHHHHHHHhcCCCCH Confidence 110 0001112345667777776652 1456 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEV 640 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~L 640 (747) .++..++.+|.+++..... .......+...++++.|+.++... ++.++..++.+|.+++..... ..+...++++.| T Consensus 458 ~v~~~a~~~L~~l~~~~~~--~~~~~~~~~~~~~i~~L~~ll~~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~l~~L 535 (780) T 2Z6G_A 458 DITEPAICALRHLTSRHQD--AEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRL 535 (780) T ss_pred HHHHHHHHHHHHHHcCCcc--HHHHHHHHHHCCcHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCHHHHHHHHhCChHHHH Confidence 7788899999998865321 000112223456788888888765 577889999999999876333 233455677788 Q NP_000290.2 641 TRLLTSHTGN----------------TSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 641 l~LL~s~s~~----------------~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) +.++...... ...+..++..++.+|.+|+.. ......+...++++.|+.++.+. ++.++..+ T Consensus 536 ~~ll~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~a~~aL~~L~~~-~~~~~~~~~~~~l~~L~~~l~~~-~~~v~~~a 613 (780) T 2Z6G_A 536 VQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEACTGALHILARD-IHNRIVIRGLNTIPLFVQLLYSP-IENIQRVA 613 (780) T ss_pred HHHhcCCCHHHHHHHHhhhhhhhhhcCCChHHHHHHHHHHHHHHhCC-hhHHHHHHhCCcHHHHHHHhcCC-CHHHHHHH Confidence 8777652000 000234888999999999864 44444455556788888888776 78899999 Q NP_000290.2 705 RLLLSDMWSSKELQGVLRQQG 725 (747) Q Consensus 705 L~aLsnL~~~~~~~~~~~~~~ 725 (747) +.+|.+++...+....+...| T Consensus 614 ~~~L~~l~~~~~~~~~~~~~~ 634 (780) T 2Z6G_A 614 AGVLCELAQDKEAAEAIEAEG 634 (780) T ss_pred HHHHHHHhcCHHHHHHHHHCC Confidence 999999997766554444433 No 37 >1JDH_A BETA-CATENIN, hTcf-4; BETA-CATENIN, TCF4, PROTEIN-PROTEIN COMPLEX, TRANSCRIPTION; 1.9A {Homo sapiens} SCOP: a.118.1.1 Probab=98.13 E-value=6.1e-10 Score=114.95 Aligned_cols=326 Identities=17% Similarity=0.189 Sum_probs=198.8 Template_Neff=13.100 Q NP_000290.2 286 LGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKE 365 (747) Q Consensus 286 ~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~ 365 (747) .++++.+...+.+.+..++..++.++..++.............++++.+...+....++.++..++.++..+........ T Consensus 16 ~~~i~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~ 95 (529) T 1JDH_A 16 TRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLL 95 (529) T ss_dssp -CHHHHHHHHHTCSCHHHHHHHHHHHHHHHTSHHHHHHHHTCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTSHHHHH T ss_pred HhhHHHHHHHhcCCCHHHHHHHHHHHHHHhcCHHHHHHHHhCcchHHHHHHHhhCCCCHHHHHHHHHHHHHHhcCHHHHH Confidence 45677777778777788888999999888765322211111134667777777533567788899999998876544443 Q NP_000290.2 366 ELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTM 444 (747) Q Consensus 366 ~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 444 (747) .+.. ++++.|+.++..+ ++++-..+..++..-.... +..+... T Consensus 96 ~~~~~~~~~~l~~~l~~~----------------~~~~~~~a~~~l~~l~~~~--------------------~~~~~~~ 139 (529) T 1JDH_A 96 AIFKSGGIPALVKMLGSP----------------VDSVLFYAITTLHNLLLHQ--------------------EGAKMAV 139 (529) T ss_dssp HHHHTTHHHHHHHHTTCS----------------CHHHHHHHHHHHHHHHHHC--------------------TTHHHHH T ss_pred HHHHcCCHHHHHHHhcCC----------------CHHHHHHHHHHHHHHHcCC--------------------cchHHHH Confidence 4444 6777777776532 3444444444433211100 0000100 Q NP_000290.2 445 RNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNN 524 (747) Q Consensus 445 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 524 (747) .-.++++.|...++. -+..-...+...|.++...- T Consensus 140 -~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~-------------------------------------- 174 (529) T 1JDH_A 140 -RLAGGLQKMVALLNK------TNVKFLAITTDCLQILAYGN-------------------------------------- 174 (529) T ss_dssp -HHHTHHHHHHHGGGC------CCHHHHHHHHHHHHHHHTTC-------------------------------------- T ss_pred -HHcChHHHHHHHhcC------CCHHHHHHHHHHHHHHhcCC-------------------------------------- Confidence 012444544444332 12222233333333332100 Q NP_000290.2 525 NYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL 604 (747) Q Consensus 525 ~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL 604 (747) ......+.+.++++.++.++....++.++..++.+|.+++.... ....+...++++.+..++ T Consensus 175 ------------~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~------~~~~~~~~~~~~~l~~~l 236 (529) T 1JDH_A 175 ------------QESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSS------NKPAIVEAGGMQALGLHL 236 (529) T ss_dssp ------------HHHHHHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTSTT------HHHHHHHTTHHHHHHTTT T ss_pred ------------HHHHHHHHHCChhHHHHHHHccCCcHHHHHHHHHHHHHHhcCCc------cHHHHHHCCHHHHHHHHc Confidence 01112234566788888888742366788889999999887532 133334567888899988 Q NP_000290.2 605 QSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSM 684 (747) Q Consensus 605 ~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~gi 684 (747) .+.++.++..++++|.+++......... .++++.+..++.+ .++.++..++.+|.+++...+.....+...+. T Consensus 237 ~~~~~~~~~~~~~~l~~l~~~~~~~~~~-~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~ 309 (529) T 1JDH_A 237 TDPSQRLVQNCLWTLRNLSDAATKQEGM-EGLLGTLVQLLGS------DDINVVTCAAGILSNLTCNNYKNKMMVCQVGG 309 (529) T ss_dssp TSSCHHHHHHHHHHHHHHHTTCTTCSCC-HHHHHHHHHHTTC------SCHHHHHHHHHHHHHHTTTCHHHHHHHHHTTH T ss_pred cCCCHHHHHHHHHHHHHHcchhhhHHHH-chHHHHHHHHhCC------CCHHHHHHHHHHHHHHhcCCHHHHHHHHHcCH Confidence 8888889999999999998763221111 4566777777765 36788899999999998765555555666677 Q NP_000290.2 685 LNNIINLCRS-SASPKAAEAARLLLSDMWSSKEL 717 (747) Q Consensus 685 L~~Ll~LL~s-~~d~eVr~aAL~aLsnL~~~~~~ 717 (747) ++.++..+.. ..++.++..++.+|.+++..... T Consensus 310 ~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~~ 343 (529) T 1JDH_A 310 IEALVRTVLRAGDREDITEPAICALRHLTSRHQE 343 (529) T ss_dssp HHHHHHHHHHHTTCHHHHHHHHHHHHHHTSSSTT T ss_pred HHHHHHHHHhcCCChHhHHHHHHHHHHHhcCccc Confidence 8888876652 12577888999999998866553 No 38 >2Z6H_A Catenin beta-1; Beta-Catenin, C-terminal Domain, Activator, Cell; 2.2A {Homo sapiens} Probab=98.12 E-value=7.3e-10 Score=121.28 Aligned_cols=378 Identities=20% Similarity=0.248 Sum_probs=205.2 Template_Neff=11.700 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++.........+...++++.+...+...+..++..++.++..++.........+ T Consensus 99 ~i~~L~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~L~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~ 178 (644) T 2Z6H_A 99 GIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLII 178 (644) T ss_pred cHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 45566666766777888899999998876543333333345677778888877778888899999998886444333334 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFF 404 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~ 404 (747) ...+++..+...+....+..++..++.++..++........+.. ++++.|..++... ++++.. T Consensus 179 ~~~~~~~~L~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~l~~l~~~l~~~----------------~~~~~~ 242 (644) T 2Z6H_A 179 LASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDP----------------SQRLVQ 242 (644) T ss_pred HHCCcHHHHHHHhcCCCCHHHHHHHHHHHHHHccChHHHHHHHHCCHHHHHHHHhcCC----------------CHHHHH Confidence 44457777777776333567788888888888765443333333 6666676666532 111222 Q NP_000290.2 405 NATGCLRKRL-----------GMRELLALVPQ-------RATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASR 466 (747) Q Consensus 405 ~~~~~~~~~~-----------~~~~~~~~~~~-------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 466 (747) .+..+|..-. .+..++.++.. .+...-.++...+......-.-.+.++.|...+.. .. T Consensus 243 ~a~~~L~~l~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~l~~L~~~l~~----~~ 318 (644) T 2Z6H_A 243 NCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLR----AG 318 (644) T ss_pred HHHHHHHHHhcCCCCHHHHCchHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCHHHHHHHHhCCHHHHHHHHHhc----CC Confidence 2222221100 01111111110 00000111111111000000112334444333221 01 Q NP_000290.2 467 CDDKSVENCMCVLHNLSYRLDAEV------------PTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEE 534 (747) Q Consensus 467 ~~~~~~~~~~~~~~~~~~~~~~~~------------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 534 (747) -+..-.+.+...|.++........ +.-.+.+... .+....+....++.+-. T Consensus 319 ~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~v~~~a~~~L~~l~---------------- 381 (644) T 2Z6H_A 319 DREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPP-SHWPLIKATVGLIRNLA---------------- 381 (644) T ss_pred CCHHHHHHHHHHHHHHHcCCCCHHHHHHHHHHCCcHHHHHHHhcCC-CCHHHHHHHHHHHHHHh---------------- Confidence 123345666777777765433210 0000000000 00000011111111111 Q NP_000290.2 535 TNPKGSGWLYHSDAIRTYLNLMGKSKK----------------------DATLEACAGALQNLTASKGLMSSGMSQLIGL 592 (747) Q Consensus 535 ~ni~~~~~lve~G~I~~LL~LL~ss~d----------------------~eVr~~AL~aL~nLs~~s~~~s~~~~~~lli 592 (747) ........+.+.++++.|+.++.. .. ..++..++.+|.+++..... ...+. T Consensus 382 ~~~~~~~~l~~~~~~~~L~~~l~~-~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~a~~~L~~l~~~~~~------~~~~~ 454 (644) T 2Z6H_A 382 LCPANHAPLREQGAIPRLVQLLVR-AHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHN------RIVIR 454 (644) T ss_pred cCHHHHHHHHHCCcHHHHHHHHcc-CCHHHHHHHhcCCchhhhhcCCCCHHHHHHHHHHHHHHhcCcch------HHHHH Confidence 001112234566788888888863 32 23777888899988865321 22334 Q NP_000290.2 593 KEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 593 e~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~ 671 (747) ..++++.|+.++.+.++.++..++.+|.+++..... ..+...++++.|..++.+ .++.++..++.+|.+++.. T Consensus 455 ~~~~i~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~L~~~l~~------~~~~v~~~a~~~L~~l~~~ 528 (644) T 2Z6H_A 455 GLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHS------RNEGVATYAAAVLFRMSED 528 (644) T ss_pred HCCcHHHHHHHHhCCCHHHHHHHHHHHHHHhcCHHHHHHHHHCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHhCC Confidence 457888899989888889999999999999876433 233445778888888876 3678999999999999875 Q NP_000290.2 672 QP 673 (747) Q Consensus 672 s~ 673 (747) .+ T Consensus 529 ~~ 530 (644) T 2Z6H_A 529 KP 530 (644) T ss_pred Cc Confidence 43 No 39 >6SA8_A ring-like DARPin-Armadillo fusion H83_D01, LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG; protein fusion, DARPin, Armadillo, shared; 2.4A {synthetic construct} Probab=98.11 E-value=7.7e-10 Score=121.20 Aligned_cols=342 Identities=20% Similarity=0.251 Sum_probs=215.3 Template_Neff=11.900 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.+..++..++..|..++.........+...++++.+..++.+.++.++..++.++..++........ T Consensus 177 ~~~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~ 256 (671) T 6SA8_A 177 KKILKDLVKKLSSPNENELQNALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQ 256 (671) T ss_dssp HHHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHH T ss_pred HHHHHHHHHhcCCCCHHHHHHHHHHHHHHHcCCcHHHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHH Confidence 44566677777777778888899999888765433333444456778888888877888899999999988764443333 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPE 401 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~ 401 (747) .+...+.++.+...+. +.++.++..++.++..++... .....+.. ++++.|+.++... +++ T Consensus 257 ~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~L~~~l~~~----------------~~~ 319 (671) T 6SA8_A 257 AVIDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSP----------------NEQ 319 (671) T ss_dssp HHHHTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCS----------------CHH T ss_pred HHHHcCHHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCcHHHHHHHHhChHHHHHHHhcCC----------------cHH Confidence 3444567778888876 566788889999999888643 22233333 6777777776531 344 Q NP_000290.2 402 VFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHN 481 (747) Q Consensus 402 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 481 (747) +-..+..+|..-.. ..+ ..+..+. -.++++.|+..++.. +....+.++..|.+ T Consensus 320 v~~~a~~~L~~l~~------~~~--------------~~~~~~~-~~~~l~~l~~~l~~~------~~~~~~~a~~~L~~ 372 (671) T 6SA8_A 320 ILQEALWALSNIAS------GGN--------------EQIQAVI-DAGALPALVQLLSSP------NEQILQEALWALSN 372 (671) T ss_dssp HHHHHHHHHHHHTT------SCH--------------HHHHHHH-HTTHHHHHHHHTTCS------CHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHhc------CCc--------------HHHHHHH-hcChHHHHHHHhcCC------CHHHHHHHHHHHHH Confidence 44444433322110 000 0011111 123444554444321 22333344444444 Q NP_000290.2 482 LSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKK 561 (747) Q Consensus 482 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d 561 (747) +...- ......+.+.++++.|+.++. ..+ T Consensus 373 l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~ 401 (671) T 6SA8_A 373 IASGG--------------------------------------------------NEQIQAVIDAGALPALVQLLS-SPN 401 (671) T ss_dssp HTTSC--------------------------------------------------HHHHHHHHHTTHHHHHHHGGG-CSC T ss_pred HHcCC--------------------------------------------------cHHHHHHHHcCcHHHHHHHhc-CCC Confidence 43200 001112245567888888887 467 Q NP_000290.2 562 DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL-L-HRVMGNQVFPE 639 (747) Q Consensus 562 ~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e-~-~~ll~~giI~~ 639 (747) +.++..++.+|.+++..... ....+.+.++++.|+.++.+.++.++..++.+|.+++.... . ..+...++++. T Consensus 402 ~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~L~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~ 476 (671) T 6SA8_A 402 EQILQEALWALSNIASGGNE-----QIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPA 476 (671) T ss_dssp HHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTCHHHHHHGGGCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHH T ss_pred HHHHHHHHHHHHhhcCCCHH-----HHHHHHhcCcHHHHHHHcCCCCHHHHHHHHHHHHHHHcCChHHHHHHHhcCcHHH Confidence 78888999999999875332 23333456788899999988888999999999999996632 2 23345667888 Q NP_000290.2 640 VTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINL 691 (747) Q Consensus 640 Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~L 691 (747) |..++.+ .++.++..++.+|.+|+...+.....+...+.++.++.. T Consensus 477 l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~ll~~ 522 (671) T 6SA8_A 477 LVQLLSS------PNEQIQDEAEKTLLNIANGSEEQQKAVYDAGALKYLLII 522 (671) T ss_dssp HHHHTTC------SCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHH T ss_pred HHHHhhC------CCHHHHHHHHHHHHHHHcCCHHHHHHHhcccHHHHHHHH Confidence 8888876 367889999999999987655555555555555555544 No 40 >4RXH_B Importin subunit alpha, Large T; ARM repeat, NLS, nuclear import; 1.7553A {Neurospora crassa} Probab=98.05 E-value=1.2e-09 Score=113.39 Aligned_cols=157 Identities=18% Similarity=0.227 Sum_probs=116.8 Template_Neff=12.500 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++++.++.++. +.++.++..++.+|.+++..... ....+...++++.+..++.+.++.++..++.+|.+++. T Consensus 196 ~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~ 269 (495) T 4RXH_B 196 IAPALPVLAKLVY-SLDDEVLIDACWAISYLSDGSND-----KIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVT 269 (495) T ss_dssp HTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHTSSCHH-----HHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTT T ss_pred hcCHHHHHHHHhh-CCCHHHHHHHHHHHHHHhcCCHH-----HHHHHHHCChHHHHHHHHhcCCccHHHHHHHHHHHHhc Confidence 3456777888887 46778888999999998864332 22333455788888888888888899999999999987 Q NP_000290.2 625 HP-LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAE 702 (747) Q Consensus 625 ~~-e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~ 702 (747) .. .. ..+...++++.+..++.+ .++.++..++.+|.+++...+.....+...++++.|..++.+. ++.++. T Consensus 270 ~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~ 342 (495) T 4RXH_B 270 GDDVQTQVIINCGALPCLLSLLSS------NKDGIRKEACWTISNITAGNSAQIQSVIDANIIPPLIHLLSHA-DLKTRK 342 (495) T ss_dssp SCHHHHHHHHHTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHHHSS-CHHHHH T ss_pred CCHHHHHHHHhCCHHHHHHHHHhC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHHhcC-CHHHHH Confidence 63 22 233445677888888876 3678899999999999876554444555556788888888766 778899 Q NP_000290.2 703 AARLLLSDMWSS 714 (747) Q Consensus 703 aAL~aLsnL~~~ 714 (747) .++.+|.+++.. T Consensus 343 ~a~~~l~~l~~~ 354 (495) T 4RXH_B 343 EACWAISNATSG 354 (495) T ss_dssp HHHHHHHHTTTT T ss_pred HHHHHHHHHHhc Confidence 999999998876 No 41 >5XJG_A Vacuolar protein 8, Nucleus-vacuole junction; Vac8p, Nvj1p, Membrane contact site; HET: B3P, PE5; 2.4A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=98.04 E-value=1.3e-09 Score=111.79 Aligned_cols=133 Identities=20% Similarity=0.248 Sum_probs=82.5 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+.... .....+...++++.+...+.+.+..++..++.++..++.......... T Consensus 159 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 237 (506) T 5XJG_A 159 ALIPLTKLAKSKHIRVQRNATGALLNMTHSE-ENRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIAVDEANRKKLA 237 (506) T ss_dssp THHHHHHHTTCSSHHHHHHHHHHHHHTCSSH-HHHHHHHHHTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSHHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHcCCH-HHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCHHHHHHHH Confidence 4555666666667788888899988887542 222233334567777777777777888888998888875433221111 Q NP_000290.2 326 -RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 -l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++........+.. ++++.+..++. T Consensus 238 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~ 293 (506) T 5XJG_A 238 QTEPRLVSKLVSLMD-SPSSRVKCQATLALRNLASDTSYQLEIVRAGGLPHLVKLIQ 293 (506) T ss_dssp HHCTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHTTSHHHHHHHHHTTHHHHHHHHHT T ss_pred hhChhHHHHHHHHcc-CCCHHHHHHHHHHHHHHhCCChhHHHHHHcCcHHHHHHHHh Confidence 11235666677775 45667788888888888765433333332 45555555554 No 42 >6KBM_A Vacuolar protein 8, Autophagy-related protein; Armadillo repeats, complex, PROTEIN BINDING-PROTEIN; 2.902A {Saccharomyces cerevisiae} Probab=98.04 E-value=1.3e-09 Score=111.79 Aligned_cols=133 Identities=20% Similarity=0.248 Sum_probs=82.5 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+.... .....+...++++.+...+.+.+..++..++.++..++.......... T Consensus 159 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 237 (506) T 6KBM_A 159 ALIPLTKLAKSKHIRVQRNATGALLNMTHSE-ENRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIAVDEANRKKLA 237 (506) T ss_dssp THHHHHHHTTCSSHHHHHHHHHHHHHTCSSH-HHHHHHHHTTCHHHHHHGGGCSCHHHHHHHHHHHHHHTTSHHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHcCCH-HHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCHHHHHHHH Confidence 4555666666667788888899988887542 222233334567777777777777888888998888875433221111 Q NP_000290.2 326 -RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 -l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++........+.. ++++.+..++. T Consensus 238 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~ 293 (506) T 6KBM_A 238 QTEPRLVSKLVSLMD-SPSSRVKCQATLALRNLASDTSYQLEIVRAGGLPHLVKLIQ 293 (506) T ss_dssp HHCTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHHTSHHHHHHHHHTTCHHHHHHHHT T ss_pred hhChhHHHHHHHHcc-CCCHHHHHHHHHHHHHHhCCChhHHHHHHcCcHHHHHHHHh Confidence 11235666677775 45667788888888888765433333332 45555555554 No 43 >4TNM_A Importin-alpha3 / MOS6; armadillo repeat; 2.9A {Arabidopsis thaliana} Probab=97.99 E-value=2e-09 Score=113.28 Aligned_cols=158 Identities=18% Similarity=0.255 Sum_probs=115.7 Template_Neff=12.300 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++++.|+.++. +.++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++. T Consensus 243 ~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~ 316 (531) T 4TNM_A 243 TQPALPVLERLVQ-SMDEEVLTDACWALSYLSDNSND-----KIQAVIEAGVVPRLIQLLGHSSPSVLIPALRTIGNIVT 316 (531) T ss_pred hcchHHHHHHHhc-CCCHHHHHHHHHHHHHHhCCCHH-----HHHHHHHCChHHHHHHHHhCCCHHHHHHHHHHHHHHHC Confidence 3456777777777 46777888999999998865332 22333456788889999988888899999999999987 Q NP_000290.2 625 HPLL--HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAE 702 (747) Q Consensus 625 ~~e~--~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~ 702 (747) .... ......++++.+..++... .++.++..++.+|.+++...+.....+...++++.|+.++.+. ++.++. T Consensus 317 ~~~~~~~~~~~~~~~~~l~~~l~~~-----~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~ 390 (531) T 4TNM_A 317 GDDLQTQMVLDQQALPCLLNLLKNN-----YKKSIKKEACWTISNITAGNADQIQAVIDAGIIQSLVWVLQSA-EFEVKK 390 (531) T ss_pred CCHHHHHHHHHCCcHHHHHHHhcCC-----CCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCcHHHHHHHhcCC-CHHHHH Confidence 6322 2333446777888877652 2567888999999999876545555555666788888888765 778888 Q NP_000290.2 703 AARLLLSDMWSS 714 (747) Q Consensus 703 aAL~aLsnL~~~ 714 (747) .++.+|.+++.. T Consensus 391 ~a~~~l~~l~~~ 402 (531) T 4TNM_A 391 EAAWGISNATSG 402 (531) T ss_pred HHHHHHHHHHcC Confidence 899999888864 No 44 >6KBN_A Vacuolar protein 8, Autophagy-related protein; Armadillo repeats, complex, PROTEIN BINDING-PROTEIN; 3.2A {Saccharomyces cerevisiae} Probab=97.98 E-value=2.1e-09 Score=112.87 Aligned_cols=133 Identities=20% Similarity=0.248 Sum_probs=86.0 Template_Neff=12.700 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+.... .....+...++++.+...+.+.+..++..++.++..++.......... T Consensus 153 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 231 (563) T 6KBN_A 153 ALIPLTKLAKSKHIRVQRNATGALLNMTHSE-ENRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIAVDEANRKKLA 231 (563) T ss_dssp THHHHHHHTTCSSHHHHHHHHHHHHHTTSSH-HHHHHHHTTTCHHHHHHHTTCSSHHHHHHHHHHHHHHTTSHHHHHHHH T ss_pred hHHHHHHHccCCCHHHHHHHHHHHHHHhCCH-HHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHhCCHHHHHHHH Confidence 4555666666667788888999998887542 222233334577777777777777888899999988876433221111 Q NP_000290.2 326 -RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 -l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++........+.. ++++.+..++. T Consensus 232 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~ 287 (563) T 6KBN_A 232 QTEPRLVSKLVSLMD-SPSSRVKCQATLALRNLASDTSYQLEIVRAGGLPHLVKLIQ 287 (563) T ss_dssp HHCSSHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSHHHHHHHHHTTCHHHHHHHHT T ss_pred hhchhHHHHHHHHhc-CCCHHHHHHHHHHHHHHhCChhHHHHHHHCCcHHHHHHHHh Confidence 11236667777775 55677888899999988875443333333 56677776664 No 45 >6KBN_C Vacuolar protein 8, Autophagy-related protein; Armadillo repeats, complex, PROTEIN BINDING-PROTEIN; 3.2A {Saccharomyces cerevisiae} Probab=97.98 E-value=2.1e-09 Score=112.87 Aligned_cols=133 Identities=20% Similarity=0.248 Sum_probs=86.0 Template_Neff=12.700 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+.... .....+...++++.+...+.+.+..++..++.++..++.......... T Consensus 153 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 231 (563) T 6KBN_C 153 ALIPLTKLAKSKHIRVQRNATGALLNMTHSE-ENRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIAVDEANRKKLA 231 (563) T ss_dssp CHHHHHHHTTSSSHHHHHHHHHHHHHHTSSH-HHHHHHHTTTCHHHHHHHTTCSSHHHHHHHHHHHHHHTTSHHHHHHHH T ss_pred hHHHHHHHccCCCHHHHHHHHHHHHHHhCCH-HHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHhCCHHHHHHHH Confidence 4555666666667788888999998887542 222233334577777777777777888899999988876433221111 Q NP_000290.2 326 -RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 -l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++........+.. ++++.+..++. T Consensus 232 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~ 287 (563) T 6KBN_C 232 QTEPRLVSKLVSLMD-SPSSRVKCQATLALRNLASDTSYQLEIVRAGGLPHLVKLIQ 287 (563) T ss_dssp HSSTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHTTSHHHHHHHHHTTCHHHHHHHTT T ss_pred hhchhHHHHHHHHhc-CCCHHHHHHHHHHHHHHhCChhHHHHHHHCCcHHHHHHHHh Confidence 11236667777775 55677888899999988875443333333 56677776664 No 46 >4EV8_A Catenin beta-1; mouse catenin, CELL ADHESION; HET: URE; 1.9A {Mus musculus} Probab=97.98 E-value=2.1e-09 Score=111.06 Aligned_cols=323 Identities=18% Similarity=0.194 Sum_probs=192.8 Template_Neff=13.100 Q NP_000290.2 286 LGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRR-QNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELK 364 (747) Q Consensus 286 ~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~-~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~ 364 (747) .++++.+...+.+.++.++..++.++..+....... ..+.. .+++..+...+....++.++..++.++..++...... T Consensus 17 ~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~-~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~ 95 (538) T 4EV8_A 17 TRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASR-HAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGL 95 (538) T ss_pred cCcHHHHHHHhcCCCHHHHHHHHHHHHHHhCChhhH-HHHHhCCChHHHHHHHhcCCCCHHHHHHHHHHHHHHcCCHHHH Confidence 356677777777777888888999998887643322 12222 2466677776653446678888999999887654433 Q NP_000290.2 365 EELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQT 443 (747) Q Consensus 365 ~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 443 (747) ..+.. ++++.|+.++..+ ++++...+..+|..-... . +..++. T Consensus 96 ~~~~~~~~~~~l~~~l~~~----------------~~~~~~~a~~~l~~l~~~------~--------------~~~~~~ 139 (538) T 4EV8_A 96 LAIFKSGGIPALVKMLGSP----------------VDSVLFYAITTLHNLLLH------Q--------------EGAKMA 139 (538) T ss_pred HHHHHCCcHHHHHHHhCCC----------------CHHHHHHHHHHHHHHhCC------C--------------HHHHHH Confidence 33333 6777777776532 344444444333221100 0 000000 Q NP_000290.2 444 MRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMN 523 (747) Q Consensus 444 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 523 (747) . .-.+++..|...++. -+..-...+...|.++... T Consensus 140 ~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~-------------------------------------- 174 (538) T 4EV8_A 140 V-RLAGGLQKMVALLNK------TNVKFLAITTDCLQILAYG-------------------------------------- 174 (538) T ss_pred H-HHCChHHHHHHHhcC------CCHHHHHHHHHHHHHHhcC-------------------------------------- Confidence 0 012444444444332 0112222222233332210 Q NP_000290.2 524 NNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARL 603 (747) Q Consensus 524 ~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~L 603 (747) +......+.+.++++.|+.++....+..++..++.+|.+++..... ...+...++++.+..+ T Consensus 175 ------------~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~l~~~ 236 (538) T 4EV8_A 175 ------------NQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSN------KPAIVEAGGMQALGLH 236 (538) T ss_pred ------------CHHHHHHHHHCChHHHHHHHHcCCCCHHHHHHHHHHHHHHcCCHHH------HHHHHHCCcHHHHHHH Confidence 0011112245667888888887423667788899999988865321 2333456788889999 Q NP_000290.2 604 LQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSS 683 (747) Q Consensus 604 L~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~g 683 (747) +.+.++.++..++.+|.+++......... .++++.+..++.+ .++.++..++.+|.+++...+.....+...+ T Consensus 237 l~~~~~~~~~~a~~~l~~l~~~~~~~~~~-~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~ 309 (538) T 4EV8_A 237 LTDPSQRLVQNCLWTLRNLSDAATKQEGM-EGLLGTLVQLLGS------DDINVVTCAAGILSNLTCNNYKNKMMVCQVG 309 (538) T ss_pred hcCCCHHHHHHHHHHHHHHHcCCCchHHH-cCcHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHHCC Confidence 98888889999999999998763221111 3466777777765 3678888999999999765555555555666 Q NP_000290.2 684 MLNNIINLCR--SSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 684 iL~~Ll~LL~--s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) .++.++..+. .. ++.++..++.+|.+++...+ T Consensus 310 ~~~~l~~~l~~~~~-~~~~~~~a~~~l~~l~~~~~ 343 (538) T 4EV8_A 310 GIEALVRTVLRAGD-REDITEPAICALRHLTSRHQ 343 (538) T ss_pred cHHHHHHHHhcCCC-CHHHHHHHHHHHHHHHcCCC Confidence 7777777665 23 56677788888888876554 No 47 >4BPL_A IMPORTIN SUBUNIT ALPHA-1A, NUCLEOPLASMIN NLS; TRANSPORT PROTEIN, NUCLEAR IMPORT, NUCLEAR; 2.3A {ORYZA SATIVA} Probab=97.98 E-value=2.2e-09 Score=108.63 Aligned_cols=158 Identities=18% Similarity=0.251 Sum_probs=116.0 Template_Neff=13.000 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++++.|+.++. +.++.++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++. T Consensus 168 ~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~ 241 (454) T 4BPL_A 168 TRPALPALARLIH-SNDEEVLTDACWALSYLSDGTND-----KIQAVIEAGVCPRLVELLLHPSPSVLIPALRTVGNIVT 241 (454) T ss_dssp HTTHHHHHHHHTT-CCCHHHHHHHHHHHHHHTSSCHH-----HHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHHHHHh-CCCHHHHHHHHHHHHHHhcCChH-----HHHHHHHCCcHHHHHHHhhCCChHHHHHHHHHHHHHhc Confidence 3456777777777 46777888899999998865332 22333455788888898888888899999999999987 Q NP_000290.2 625 HPL-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAE 702 (747) Q Consensus 625 ~~e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~ 702 (747) ... . ..+...++++.+..++... .++.++..++.+|.+++...+.....+...++++.|..++.+. ++.++. T Consensus 242 ~~~~~~~~~~~~~~~~~l~~~l~~~-----~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~ 315 (454) T 4BPL_A 242 GDDAQTQCIIDHQALPCLLSLLTQN-----LKKSIKKEACWTISNITAGNKDQIQAVINAGIIGPLVNLLQTA-EFDIKK 315 (454) T ss_dssp SCHHHHHHHHTTTHHHHHHHHHHSS-----CCHHHHHHHHHHHHHHHTSCHHHHHHHHHHTCHHHHHHHHHHS-CHHHHH T ss_pred CCHHHHHHHHHCChHHHHHHHHHhc-----CCHHHHHHHHHHHHHHhcCCHHHHHHHHhCCcHHHHHHHhhcC-CHHHHH Confidence 632 2 2334456777888887652 2577889999999999876555555555666788888888766 778888 Q NP_000290.2 703 AARLLLSDMWSS 714 (747) Q Consensus 703 aAL~aLsnL~~~ 714 (747) .++.+|.+++.. T Consensus 316 ~a~~~l~~l~~~ 327 (454) T 4BPL_A 316 EAAWAISNATSG 327 (454) T ss_dssp HHHHHHHHHHHH T ss_pred HHHHHHHHHHcC Confidence 899999888863 No 48 >4PLS_B Arm00010; PEPTIDE BINDING PROTEIN, designed armadillo; HET: CA; 2.35A {synthetic construct} Probab=97.96 E-value=2.5e-09 Score=100.09 Aligned_cols=112 Identities=25% Similarity=0.272 Sum_probs=72.2 Template_Neff=13.200 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETR 326 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll 326 (747) ++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.+.++.++..++.++..++.........+. T Consensus 3 i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~ 82 (281) T 4PLS_B 3 LPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVI 82 (281) T ss_dssp HHHHHHTTTCSCHHHHHHHHHHHHHHHTCSHHHHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHHH T ss_pred HHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCHHHHHHHH Confidence 34556666667778888899999888765444333444455777777877777778888888888888754333222333 Q NP_000290.2 327 RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 327 ~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ..++++.+...+. +.++.++..++.++..++. T Consensus 83 ~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~ 114 (281) T 4PLS_B 83 DAGALPALVQLLS-SPNEQILQEALWTLGNIAS 114 (281) T ss_dssp HTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHTT T ss_pred hCCcHHHHHHHcC-CCCHHHHHHHHHHHHHHhc Confidence 3345566666665 4455666666666666654 No 49 >5Z8H_A Adenomatous polyposis coli protein, Peptide; APC, inhibitor, PROTEIN BINDING-INHIBITOR complex; HET: PHQ, GOL; 1.79A {Homo sapiens} Probab=97.95 E-value=2.6e-09 Score=104.87 Aligned_cols=123 Identities=24% Similarity=0.347 Sum_probs=80.3 Template_Neff=12.500 Q NP_000290.2 258 DEKYQAIGAYYIQHTCFQDESAKQQVYQ-LGGICKLVDLLRSPNQNVQQAAAGALRNLVFR-STTNKLETRRQNGIREAV 335 (747) Q Consensus 258 d~eVr~sAL~aLsnLs~~~~~~~~~li~-~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~-~~~~~~~ll~~~IL~~Ll 335 (747) ++.++..++.++.+++...+.....+.. .++++.+..++...++.++..++.++.+++.. .......+...++++.+. T Consensus 92 ~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~ 171 (339) T 5Z8H_A 92 SITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALM 171 (339) T ss_pred CHHHHHHHHHHHHHHcCCCHHHHHHHHHhcChHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCCHHHHHHHHHCCcHHHHH Confidence 6778888999999887644443333444 46778888888777788889999999998864 222223333456777777 Q NP_000290.2 336 SLLRRTGNAEIQKQLTGLLWNLSS-TDELKEELIA--DALPVLADRVI 380 (747) Q Consensus 336 ~lL~ss~d~eVr~~AL~aLsnLas-~~~~~~~Lve--giLe~Lv~LL~ 380 (747) ..+....++.++..++.++.+++. .......+.. ++++.++.++. T Consensus 172 ~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 219 (339) T 5Z8H_A 172 ECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLT 219 (339) T ss_pred HHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHhcChHHHHHHHhc Confidence 777622466778888888888876 3333323322 45555555554 No 50 >2Z6H_A Catenin beta-1; Beta-Catenin, C-terminal Domain, Activator, Cell; 2.2A {Homo sapiens} Probab=97.95 E-value=2.8e-09 Score=116.50 Aligned_cols=415 Identities=18% Similarity=0.223 Sum_probs=234.1 Template_Neff=11.700 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) ++..+...+. ..+..++..++.+|..++.... ....+...++++.+...+.+.+..++..++.++..++......... T Consensus 57 ~i~~L~~~l~~~~~~~v~~~a~~~L~~l~~~~~-~~~~~~~~~~i~~L~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 135 (644) T 2Z6H_A 57 MVSAIVRTMQNTNDVETARCTAGTLHNLSHHRE-GLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMA 135 (644) T ss_pred hHHHHHHHHcCCCCHHHHHHHHHHHHHHhCCHH-HHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 4455555555 4566778888888888865432 2223334567778888887777888899999999888654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...++++.+...+. ..+..++..++.++..++.... ....+.. ++++.|+.++... .++++ T Consensus 136 ~~~~~~~~~L~~~l~-~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~L~~~l~~~---------------~~~~~ 199 (644) T 2Z6H_A 136 VRLAGGLQKMVALLN-KTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTY---------------TYEKL 199 (644) T ss_pred HHHCChHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhcCC---------------CCHHH Confidence 333467777877776 5567888889999999886432 2223333 6777777777642 12233 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..++..-.. .+..+..+ ...+.++.|...+.. .+....++++..|.++ T Consensus 200 ~~~a~~~L~~l~~---------------------~~~~~~~~-~~~~~l~~l~~~l~~------~~~~~~~~a~~~L~~l 251 (644) T 2Z6H_A 200 LWTTSRVLKVLSV---------------------CSSNKPAI-VEAGGMQALGLHLTD------PSQRLVQNCLWTLRNL 251 (644) T ss_pred HHHHHHHHHHHcc---------------------ChHHHHHH-HHCCHHHHHHHHhcC------CCHHHHHHHHHHHHHH Confidence 3333333321100 00000000 012334444333321 1334445566666666 Q NP_000290.2 483 SYRLDAE------VPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLM 556 (747) Q Consensus 483 ~~~~~~~------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL 556 (747) ....... ++.-...+.. .+.-.......++.+ ....+......+.+.++++.|+..+ T Consensus 252 ~~~~~~~~~~~~~~~~l~~~l~~--~~~~v~~~a~~~L~~---------------l~~~~~~~~~~~~~~~~l~~L~~~l 314 (644) T 2Z6H_A 252 SDAATKQEGMEGLLGTLVQLLGS--DDINVVTCAAGILSN---------------LTCNNYKNKMMVCQVGGIEALVRTV 314 (644) T ss_pred hcCCCCHHHHCchHHHHHHHhcC--CCHHHHHHHHHHHHH---------------HhCCCHHHHHHHHhCCHHHHHHHHH Confidence 5432210 0000000000 000000001111111 0011112223345667888888877 Q NP_000290.2 557 GK-SKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRHPLL-HRVMG 633 (747) Q Consensus 557 ~s-s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~~e~-~~ll~ 633 (747) .. ..++.++..++.+|.+++..... .......+...++++.|+.++.+. +..++..++.+|.+++..... ..+.. T Consensus 315 ~~~~~~~~v~~~a~~~L~~l~~~~~~--~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~~~a~~~L~~l~~~~~~~~~l~~ 392 (644) T 2Z6H_A 315 LRAGDREDITEPAICALRHLTSRHQE--AEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLRE 392 (644) T ss_pred hcCCCCHHHHHHHHHHHHHHHcCCCC--HHHHHHHHHHCCcHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCHHHHHHHHH Confidence 52 14567788899999999875331 000012223457788888888765 678889999999999876433 23344 Q NP_000290.2 634 NQVFPEVTRLLTSHTGN----------------TSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSAS 697 (747) Q Consensus 634 ~giI~~Ll~LL~s~s~~----------------~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d 697 (747) .++++.|+.++...... ......++..++.+|.+++... .....+...++++.|+.++.+. + T Consensus 393 ~~~~~~L~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~a~~~L~~l~~~~-~~~~~~~~~~~i~~l~~~l~~~-~ 470 (644) T 2Z6H_A 393 QGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDV-HNRIVIRGLNTIPLFVQLLYSP-I 470 (644) T ss_pred CCcHHHHHHHHccCCHHHHHHHhcCCchhhhhcCCCCHHHHHHHHHHHHHHhcCc-chHHHHHHCCcHHHHHHHHhCC-C Confidence 56777777777652100 0002347788999999998753 3334444556788888888776 7 Q NP_000290.2 698 PKAAEAARLLLSDMWSSKELQGVLRQQGF 726 (747) Q Consensus 698 ~eVr~aAL~aLsnL~~~~~~~~~~~~~~~ 726 (747) +.++..++.+|.+++...+....+...|+ T Consensus 471 ~~v~~~a~~~L~~l~~~~~~~~~~~~~~~ 499 (644) T 2Z6H_A 471 ENIQRVAAGVLCELAQDKEAAEAIEAEGA 499 (644) T ss_pred HHHHHHHHHHHHHHhcCHHHHHHHHHCCc Confidence 88999999999999987766555544443 No 51 >5AEI_B DESIGNED ARMADILLO REPEAT PROTEIN YIIIM5AII; DE NOVO PROTEIN, PROTEIN-PEPTIDE COMPLEX; HET: CA, ACT; 1.83A {SYNTHETIC CONSTRUCT} Probab=97.94 E-value=2.9e-09 Score=99.92 Aligned_cols=114 Identities=25% Similarity=0.274 Sum_probs=73.1 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.+.++.++..++.++..++.........+ T Consensus 5 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 84 (286) T 5AEI_B 5 ELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 84 (286) T ss_dssp CHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHhCCHHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666677788888999988876544333334444567777777777777888888888888875433322223 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. +.++.++..++.++..++.. T Consensus 85 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 118 (286) T 5AEI_B 85 IDAGALPALVQLLS-SPNEQILQEALWALSNIASG 118 (286) T ss_dssp HHHTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTS T ss_pred HHcChHHHHHHHhh-CCCHHHHHHHHHHHHHHhCC Confidence 33345566666665 44556666677777666643 No 52 >4B8J_A IMPORTIN SUBUNIT ALPHA-1A; TRANSPORT PROTEIN, NUCLEAR LOCALIZATION SIGNAL; 2.001A {ORYZA SATIVA JAPONICA GROUP} Probab=97.93 E-value=3.2e-09 Score=111.25 Aligned_cols=160 Identities=20% Similarity=0.243 Sum_probs=114.5 Template_Neff=12.400 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) .+.++++.++..+....++.++..++.+|.+++..... .......++++.|..++.+.++.++..++.+|.+++ T Consensus 199 ~~~~~l~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~ 272 (528) T 4B8J_A 199 LANGALLPLLAQLNEHTKLSMLRNATWTLSNFCRGKPQ------PSFEQTRPALPALARLIHSNDEEVLTDACWALSYLS 272 (528) T ss_dssp HHTTCHHHHHHTCCTTCCHHHHHHHHHHHHHHHCSSSC------CCHHHHTTHHHHHHHHTTCCCHHHHHHHHHHHHHHT T ss_pred HHCCcHHHHHHHHccCCCHHHHHHHHHHHHHHhCCCCC------CCHHHHhhHHHHHHHHhcCCCHHHHHHHHHHHHHHh Confidence 34556777777765334567788899999998865321 222234578888888888888889999999999998 Q NP_000290.2 624 RH-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAA 701 (747) Q Consensus 624 ~~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr 701 (747) .. ... ..+...++++.++.++.+ .++.++..++.+|.+++...+.....+...++++.|+.++.+..+..++ T Consensus 273 ~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~ 346 (528) T 4B8J_A 273 DGTNDKIQAVIEAGVCPRLVELLLH------PSPSVLIPALRTVGNIVTGDDAQTQCIIDHQALPCLLSLLTQNLKKSIK 346 (528) T ss_dssp SSCHHHHHHHHHTTCHHHHHHHTTC------SCHHHHHHHHHHHHHHTTSCHHHHHHHHTTTHHHHHHHHHHSCCCHHHH T ss_pred cCChHHHHHHHHCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHHhcCCCHHHH Confidence 76 222 233445677888888776 3678889999999999875454444555556788888887654356788 Q NP_000290.2 702 EAARLLLSDMWSSK 715 (747) Q Consensus 702 ~aAL~aLsnL~~~~ 715 (747) ..++.+|.+++... T Consensus 347 ~~a~~~l~~l~~~~ 360 (528) T 4B8J_A 347 KEACWTISNITAGN 360 (528) T ss_dssp HHHHHHHHHHHTSC T ss_pred HHHHHHHHHHHcCC Confidence 89999999987543 No 53 >4R10_A Protein humpback-2, Cadherin-related hmr-1; armadillo repeat, cell adhesion, phosphorylation; HET: SEP; 2.3A {Caenorhabditis elegans} Probab=97.89 E-value=4.1e-09 Score=110.79 Aligned_cols=417 Identities=14% Similarity=0.174 Sum_probs=224.8 Template_Neff=12.700 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.+|..+.... .....+...++++.+...+.+.++.++..++.++..++......... T Consensus 73 ~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 151 (572) T 4R10_A 73 SFVEALMAASKSSNVNVRRNAIGALSHMSEQR-GGPLLIFRSGGLAEIIRMLYDSLESVVHYAVTTLRNLLMHVSDSRAQ 151 (572) T ss_dssp HHHHHHHHHTTCSCHHHHHHHHHHHHHHTTST-THHHHHHHTTTHHHHHHGGGCSCHHHHHHHHHHHHHHHHHCTHHHHH T ss_pred cHHHHHHHHHhCCCHHHHHHHHHHHHHHhcCC-ChHHHHHhCCcHHHHHHHHhCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 44566666676677788888999998887643 22233334567777777777777888899999999887544333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...++++.+...+. ..++.++..++.++..++... .....+.. ++++.+..++... ..++++ T Consensus 152 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~--------------~~~~~~ 216 (572) T 4R10_A 152 ARALNAVEALTPHLH-KTNPKLLAQVADGLYFLLIDDAPSKITFLSLLGPQILVSILREY--------------SDHRKL 216 (572) T ss_dssp HHHTTHHHHHGGGGG-CCCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHHC--------------TTCHHH T ss_pred HHHCCHHHHHHHHHh-cCCHHHHHHHHHHHHHHHCCChHHHHHHHhccHHHHHHHHHHHC--------------CCCHHH Confidence 334467777777776 556788888999999887543 22223333 6777777776521 012333 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..++..-. ..+..+..+.. .+.++.+...+... -+..-...++.+|.++ T Consensus 217 ~~~a~~~l~~l~---------------------~~~~~~~~~~~-~~~~~~l~~~l~~~-----~~~~~~~~a~~~l~~l 269 (572) T 4R10_A 217 IYTVVRCIRSLS---------------------VCPSNKPALIS-LGCLPALYVELCTA-----KDERSQTAILVAMRNL 269 (572) T ss_dssp HHHHHHHHHHHT---------------------TSTTHHHHHHH-TTHHHHHHHHHTTC-----CSHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHh---------------------cCcchHHHHHh-CCcHHHHHHHHhcC-----CCHHHHHHHHHHHHHH Confidence 333333332110 00000111110 12222222211110 1223334445555555 Q NP_000290.2 483 SYRLDAE------VPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLM 556 (747) Q Consensus 483 ~~~~~~~------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL 556 (747) ....+.. ++.-...+. ..+.........++.+- ...+......+.+.++++.|+.++ T Consensus 270 ~~~~~~~~~~~~~~~~l~~~l~--~~~~~~~~~a~~~l~~l---------------~~~~~~~~~~~~~~~~~~~l~~~l 332 (572) T 4R10_A 270 SDSATNEENLTQLIIKLLEIIR--VANDGMTACACGTLSNL---------------TCNNTRNKQTVCSHGGIDALVTAI 332 (572) T ss_dssp GGGCTTCSCCHHHHHHHHHHHH--HCCHHHHHHHHHHHHHH---------------TSSCHHHHHHHHHTTHHHHHHHHH T ss_pred cCChHHHHHHHHHHHHHHHHhc--CCCHHHHHHHHHHHHHH---------------HcCCHHHHHHHHHCcHHHHHHHHH Confidence 4322110 000000000 00000001111111111 111112233345778888898888 Q NP_000290.2 557 GK-SKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMG- 633 (747) Q Consensus 557 ~s-s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~- 633 (747) .. ..++.++..++++|.+++..... ... ....+...++++.+..++.+.+..++..++.+|.+++..... ..+.. T Consensus 333 ~~~~~~~~~~~~a~~~l~~l~~~~~~-~~~-~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~ 410 (572) T 4R10_A 333 RRLPEVEEVTEPALCALRHCTARHSL-AEE-AQSELRFCQAFPVILDQLETLRTPVIKAALGVIRNSALLQTNLIELTQE 410 (572) T ss_dssp HHSTTCHHHHHHHHHHHHHHTSSSTT-HHH-HHHHHHHTTHHHHHHHHHTTCCHHHHHHHHHHHHHHHTSHHHHHHHHHC T ss_pred HhCCCcHHHHHHHHHHHHHhhccCCC-cHH-HHHHHhhCChHHHHHHHHhcCCHHHHHHHHHHHHHHhccchhHHHHHHH Confidence 62 23446888999999999432110 000 122233467888889998888888999999999999876332 22222 Q NP_000290.2 634 -----NQVFPEVTRLLTSHTG----------NTSNSEDILSSACYTVRNLMASQPQLAKQYFSS----------SMLNNI 688 (747) Q Consensus 634 -----~giI~~Ll~LL~s~s~----------~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~----------giL~~L 688 (747) .++++.+..++..... ....++.++..++.+|.+++.. +.....+... ++++.| T Consensus 411 ~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~-~~~~~~~~~~~~~~~~~~~~~~~~~l 489 (572) T 4R10_A 411 QTANGHTAVSLTMDILRRAITAIEENPDIAVDGVPMWGVIEGAVSALHQLANH-PAVAAACCDDIGQVGNPECPPFLDLL 489 (572) T ss_dssp CCTTCCCHHHHHHHHHHHHHHHHHHCTTCEETTEEHHHHHHHHHHHHHHHTTS-HHHHHHHHHCCCCTTCTTSCCHHHHH T ss_pred hhhCCCCcHHHHHHHHHHHHHhcccCcchhccCccHHHHHHHHHHHHHHHhCC-HHHHHHHhccccCCCCCCCccHHHHH Confidence 2344555555432000 0012356777888899988764 3333333332 567777 Q NP_000290.2 689 INLC------RSSASPKAAEAARLLLSDMWSSKELQGVLRQQG 725 (747) Q Consensus 689 l~LL------~s~~d~eVr~aAL~aLsnL~~~~~~~~~~~~~~ 725 (747) ..++ ... ++.++..++.+|.+++...+....+...| T Consensus 490 ~~~l~~~~~~~~~-~~~v~~~a~~~l~~l~~~~~~~~~~~~~~ 531 (572) T 4R10_A 490 HRLLAHPRLGSMD-DEVLEREILGLLYQLSKRPDGARAVESTG 531 (572) T ss_dssp HHHHHSHHHHSCS-CSHHHHHHHHHHHHHTSSHHHHHHHHTTT T ss_pred HHHHhCcccCCCC-hHHHHHHHHHHHHHHhcCCchhhHHHHcC Confidence 7777 444 77899999999999998766544443333 No 54 >5XJG_A Vacuolar protein 8, Nucleus-vacuole junction; Vac8p, Nvj1p, Membrane contact site; HET: B3P, PE5; 2.4A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=97.89 E-value=4.2e-09 Score=107.74 Aligned_cols=359 Identities=22% Similarity=0.262 Sum_probs=200.2 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+....... ...++++.+...+.+.++.++..++.++..++..... .... T Consensus 39 ~~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~----~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~-~~~~ 113 (506) T 5XJG_A 39 PLKALTTLVYSDNLNLQRSAALAFAEITEKYVRQ----VSREVLEPILILLQSQDPQIQVAACAALGNLAVNNEN-KLLI 113 (506) T ss_dssp HHHHHHHHHTTCCHHHHHHHHHHHHHHHHHCCCC----CCHHHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSHHH-HHHH T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHHhchHHH----HhhccHHHHHHHhhCCCHHHHHHHHHHHHHHHcCchh-HHHH Confidence 4455555666666777777777777776532211 1234566666666666667777777777777654321 1222 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFF 404 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~ 404 (747) ...++++.+...+. +.++.++..++.++..++........+.. ++++.+..++... ++++-. T Consensus 114 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~~~ 176 (506) T 5XJG_A 114 VEMGGLEPLINQMM-GDNVEVQCNAVGCITNLATRDDNKHKIATSGALIPLTKLAKSK----------------HIRVQR 176 (506) T ss_dssp HHTTTHHHHHHHHT-SSCHHHHHHHHHHHHHHTTSHHHHHHHHTTTTHHHHHHHTTCS----------------SHHHHH T ss_pred HhcCcHHHHHHHhh-CCCHHHHHHHHHHHHHHhcCcchhhHHHhcccHHHHHHHccCC----------------CHHHHH Confidence 23345666666665 45566777777777777654332222222 4555555555421 223322 Q NP_000290.2 405 NATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSY 484 (747) Q Consensus 405 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 484 (747) .+..++..- . .....+..+. ..+.++.+...++. .+..-...+...|.++.. T Consensus 177 ~a~~~l~~l---------~------------~~~~~~~~~~-~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~ 228 (506) T 5XJG_A 177 NATGALLNM---------T------------HSEENRKELV-NAGAVPVLVSLLSS------TDPDVQYYCTTALSNIAV 228 (506) T ss_dssp HHHHHHHHT---------C------------SSHHHHHHHH-HHTHHHHHHHHTTC------SCHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHH---------c------------CCHHHHHHHH-HCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHhc Confidence 222222210 0 0000000000 02333333333221 011222223333333221 Q NP_000290.2 485 RLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDAT 564 (747) Q Consensus 485 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eV 564 (747) ..+ . .........++++.++.++. ..++.+ T Consensus 229 ~~~------------------------------------------------~-~~~~~~~~~~~~~~l~~~l~-~~~~~~ 258 (506) T 5XJG_A 229 DEA------------------------------------------------N-RKKLAQTEPRLVSKLVSLMD-SPSSRV 258 (506) T ss_dssp SHH------------------------------------------------H-HHHHHHHCTTHHHHHHHHTT-CSSHHH T ss_pred CHH------------------------------------------------H-HHHHHhhChhHHHHHHHHcc-CCCHHH Confidence 000 0 00000012346777888887 466778 Q NP_000290.2 565 LEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRL 643 (747) Q Consensus 565 r~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~L 643 (747) +..++.+|.+++..... ...+...++++.+..++.+.++.++..++.+|.+++..... ......++++.+..+ T Consensus 259 ~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~ 332 (506) T 5XJG_A 259 KCQATLALRNLASDTSY------QLEIVRAGGLPHLVKLIQSDSIPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVRL 332 (506) T ss_dssp HHHHHHHHHHHTTSHHH------HHHHHHTTHHHHHHHHHTCSSHHHHHHHHHHHHHHTTSGGGHHHHHHTTCHHHHHHG T ss_pred HHHHHHHHHHHhCCChh------HHHHHHcCcHHHHHHHHhCCCHHHHHHHHHHHHHHhcCcchHHHHHHCCcHHHHHHH Confidence 88899999998875321 22334567888888888888888999999999999876433 233445677788888 Q NP_000290.2 644 LTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 644 L~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) +... .++.++..++++|.+++...+.....+...++++.+..++.+. ++.++..++.++..+....+ T Consensus 333 l~~~-----~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~l~~l~~~~~ 399 (506) T 5XJG_A 333 LDYK-----DSEEIQCHAVSTLRNLAASSEKNRKEFFESGAVEKCKELALDS-PVSVQSEISACFAILALADV 399 (506) T ss_dssp GGCT-----TCHHHHHHHHHHHHHTSSCCHHHHHHHHTTTHHHHHHHHTTSS-CHHHHHHHHHHHHHHTTCHH T ss_pred HcCC-----CCHHHHHHHHHHHHHHhcCCHHHHHHHHhCChhHHHHHHHhcC-CHHHHHHHHHHHHHHhccch Confidence 7652 2467888999999999875544444555556677777777655 56677777777776665443 No 55 >6KBM_A Vacuolar protein 8, Autophagy-related protein; Armadillo repeats, complex, PROTEIN BINDING-PROTEIN; 2.902A {Saccharomyces cerevisiae} Probab=97.89 E-value=4.2e-09 Score=107.74 Aligned_cols=359 Identities=22% Similarity=0.262 Sum_probs=200.2 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+....... ...++++.+...+.+.++.++..++.++..++..... .... T Consensus 39 ~~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~----~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~-~~~~ 113 (506) T 6KBM_A 39 PLKALTTLVYSDNLNLQRSAALAFAEITEKYVRQ----VSREVLEPILILLQSQDPQIQVAACAALGNLAVNNEN-KLLI 113 (506) T ss_dssp HHHHHHHHHHCSCHHHHHHHHHHHHHHHHHCCCC----CCHHHHHHHHHHTTCCCHHHHHHHHHHHHHHTTSHHH-HHHH T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHHhchHHH----HhhccHHHHHHHhhCCCHHHHHHHHHHHHHHHcCchh-HHHH Confidence 4455555666666777777777777776532211 1234566666666666667777777777777654321 1222 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFF 404 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~ 404 (747) ...++++.+...+. +.++.++..++.++..++........+.. ++++.+..++... ++++-. T Consensus 114 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~~~ 176 (506) T 6KBM_A 114 VEMGGLEPLINQMM-GDNVEVQCNAVGCITNLATRDDNKHKIATSGALIPLTKLAKSK----------------HIRVQR 176 (506) T ss_dssp HHTTTHHHHHHHHT-SCCHHHHHHHHHHHHHHTTSHHHHHHHHTTTTHHHHHHHTTCS----------------SHHHHH T ss_pred HhcCcHHHHHHHhh-CCCHHHHHHHHHHHHHHhcCcchhhHHHhcccHHHHHHHccCC----------------CHHHHH Confidence 23345666666665 45566777777777777654332222222 4555555555421 223322 Q NP_000290.2 405 NATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSY 484 (747) Q Consensus 405 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 484 (747) .+..++..- . .....+..+. ..+.++.+...++. .+..-...+...|.++.. T Consensus 177 ~a~~~l~~l---------~------------~~~~~~~~~~-~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~ 228 (506) T 6KBM_A 177 NATGALLNM---------T------------HSEENRKELV-NAGAVPVLVSLLSS------TDPDVQYYCTTALSNIAV 228 (506) T ss_dssp HHHHHHHHT---------C------------SSHHHHHHHH-HTTCHHHHHHGGGC------SCHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHH---------c------------CCHHHHHHHH-HCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHhc Confidence 222222210 0 0000000000 02333333333221 011222223333333221 Q NP_000290.2 485 RLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDAT 564 (747) Q Consensus 485 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eV 564 (747) ..+ . .........++++.++.++. ..++.+ T Consensus 229 ~~~------------------------------------------------~-~~~~~~~~~~~~~~l~~~l~-~~~~~~ 258 (506) T 6KBM_A 229 DEA------------------------------------------------N-RKKLAQTEPRLVSKLVSLMD-SPSSRV 258 (506) T ss_dssp SHH------------------------------------------------H-HHHHHHHCTTHHHHHHHHTT-CSSHHH T ss_pred CHH------------------------------------------------H-HHHHHhhChhHHHHHHHHcc-CCCHHH Confidence 000 0 00000012346777888887 466778 Q NP_000290.2 565 LEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRL 643 (747) Q Consensus 565 r~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~L 643 (747) +..++.+|.+++..... ...+...++++.+..++.+.++.++..++.+|.+++..... ......++++.+..+ T Consensus 259 ~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~ 332 (506) T 6KBM_A 259 KCQATLALRNLASDTSY------QLEIVRAGGLPHLVKLIQSDSIPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVRL 332 (506) T ss_dssp HHHHHHHHHHHHTSHHH------HHHHHHTTCHHHHHHHHTSSCHHHHHHHHHHHHHHTTSGGGHHHHHHTTCHHHHHHH T ss_pred HHHHHHHHHHHhCCChh------HHHHHHcCcHHHHHHHHhCCCHHHHHHHHHHHHHHhcCcchHHHHHHCCcHHHHHHH Confidence 88899999998875321 22334567888888888888888999999999999876433 233445677788888 Q NP_000290.2 644 LTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 644 L~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) +... .++.++..++++|.+++...+.....+...++++.+..++.+. ++.++..++.++..+....+ T Consensus 333 l~~~-----~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~l~~l~~~~~ 399 (506) T 6KBM_A 333 LDYK-----DSEEIQCHAVSTLRNLAASSEKNRKEFFESGAVEKCKELALDS-PVSVQSEISACFAILALADV 399 (506) T ss_dssp TTCC-----SCHHHHHHHHHHHHHHHHHCSSTHHHHHHTTHHHHHHHHSSSS-CHHHHHHHHHHHHHHTTCHH T ss_pred HcCC-----CCHHHHHHHHHHHHHHhcCCHHHHHHHHhCChhHHHHHHHhcC-CHHHHHHHHHHHHHHhccch Confidence 7652 2467888999999999875544444555556677777777655 56677777777776665443 No 56 >5IZA_A Adenomatous polyposis coli protein, ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2; APC, ASEF, Colon CANCER, Drug; 1.5A {Homo sapiens} Probab=97.89 E-value=4.5e-09 Score=105.07 Aligned_cols=297 Identities=19% Similarity=0.226 Sum_probs=180.6 Template_Neff=12.000 Q NP_000290.2 236 CSEDIECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP-----------NQNVQ 304 (747) Q Consensus 236 ~~~~~~~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~-----------d~eVr 304 (747) |.+-++..+.........+.+.++.++..++.+|.++... ......+...++++.+..++... +..++ T Consensus 23 ~~~~~~~~~~~~~~~~~~l~~~~~~~~~~a~~~L~~l~~~-~~~~~~~~~~~~~~~L~~~l~~~~~~~~~~~~~~~~~~~ 101 (354) T 5IZA_A 23 CWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFD-EEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLR 101 (354) T ss_dssp HHHHHHHCCTTCCTTTSCCCCGGGGTHHHHHHHHHHHTTS-HHHHHHHHHTTHHHHHHHHHHHHHHHHCSCCCHHHHHHH T ss_pred HHHHHHhcCCCCCCCCCCCCCCchHhHHHHHHHHHHccCC-HHHHHHHHHcCHHHHHHHHHHhhHHHhCCCCCCCCHHHH Confidence 3343444444444445556667778888899999998765 33333344456777777777643 67788 Q NP_000290.2 305 QAAAGALRNLVFRSTTNKLETRR-QNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST--DELKEELIA-DALPVLADRVI 380 (747) Q Consensus 305 ~~AL~aLs~La~~~~~~~~~ll~-~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~--~~~~~~Lve-giLe~Lv~LL~ 380 (747) ..++.++.+++.........+.. .++++.+..++. ..++.++..++.++.+++.. ......+.. ++++.|+.++. T Consensus 102 ~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 180 (354) T 5IZA_A 102 RYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLK-SESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECAL 180 (354) T ss_dssp HHHHHHHHHHHTTCHHHHHHHHHCHHHHHHHHHGGG-CSCHHHHHHHHHHHHHHHTTCCHHHHHHHHHTTHHHHHHHHHH T ss_pred HHHHHHHHHHhcCCHHHHHHHHccchHHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCCChhHHHHHHHCCHHHHHHHHHH Confidence 88999999887644333333333 467777888886 55678888999999999874 222333444 77777877775 Q NP_000290.2 381 IPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSA-DAGRQTMRNYSGLIDSLMAYVQ 459 (747) Q Consensus 381 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~ 459 (747) .. .++++...+..+|.. +... +..++.+..-.|.++.|...+. T Consensus 181 ~~---------------~~~~~~~~a~~~L~~---------------------l~~~~~~~~~~~~~~~~~~~~l~~~l~ 224 (354) T 5IZA_A 181 EV---------------KKESTLKSVLSALWN---------------------LSAHCTENKADICAVDGALAFLVGTLT 224 (354) T ss_dssp HC---------------CCHHHHHHHHHHHHH---------------------HHTTCHHHHHHHHTSTTHHHHHHHHTC T ss_pred hc---------------CCHHHHHHHHHHHHH---------------------HHcCChHhHHHHHhhccHHHHHHHHHh Confidence 42 133443333333322 1111 1122222221345555555444 Q NP_000290.2 460 NCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKG 539 (747) Q Consensus 460 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~ 539 (747) ... ...+..-.+.+..+|.+++..+. .+... T Consensus 225 ~~~--~~~~~~~~~~~~~~L~~l~~~~~-----------------------------------------------~~~~~ 255 (354) T 5IZA_A 225 YRS--QTNTLAIIESGGGILRNVSSLIA-----------------------------------------------TNEDH 255 (354) T ss_dssp SSC--SSCCHHHHHHHHHHHHHHHHHHT-----------------------------------------------TCHHH T ss_pred hcC--CCCcHHHHHHHHHHHHHHHHHhc-----------------------------------------------CCHHH Confidence 210 11113334555556666541100 01112 Q NP_000290.2 540 SGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLL 619 (747) Q Consensus 540 ~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aL 619 (747) ...+.+.++++.|+.++. ..++.++..++.+|.+++...+. ....+.+.++++.|+.++.+.++.++..++.+| T Consensus 256 ~~~l~~~~~~~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L 329 (354) T 5IZA_A 256 RQILRENNCLQTLLQHLK-SHSLTIVSNACGTLWNLSARNPK-----DQEALWDMGAVSMLKNLIHSKHKMIAMGSAAAL 329 (354) T ss_dssp HHHHHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTSSCHH-----HHHHHHHTTHHHHHHTTTTCSSHHHHHHHHHHH T ss_pred HHHHHHCCHHHHHHHHhh-cCCHHHHHHHHHHHHHHHccCHH-----HHHHHHhCCHHHHHHHHHhccCHHHHHHHHHHH Confidence 223356678888988887 46777888999999999874332 233445678899999999888888999999999 Q NP_000290.2 620 SNMSRH 625 (747) Q Consensus 620 snLa~~ 625 (747) .+++.. T Consensus 330 ~~l~~~ 335 (354) T 5IZA_A 330 RNLMAN 335 (354) T ss_dssp HHHHHT T ss_pred HHHHcc Confidence 999876 No 57 >4R0Z_A Protein humpback-2; armadillo repeat, cell adhesion; 2.005A {Caenorhabditis elegans} Probab=97.86 E-value=5.4e-09 Score=112.30 Aligned_cols=401 Identities=14% Similarity=0.143 Sum_probs=217.2 Template_Neff=12.300 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++.+++.........+...++++.+..++...+..++..++.++..++.........+ T Consensus 115 ~i~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~ 194 (629) T 4R0Z_A 115 GLAEIIRMLYDSLESVVHYAVTTLRNLLMHVSDSRAQARALNAVEALTPHLHKTNPKLLAQVADGLYFLLIDDAPSKITF 194 (629) T ss_dssp CHHHHHHGGGCSCHHHHHHHHHHHHHHHHHCTTHHHHHHHTTHHHHHGGGGGCCCHHHHHHHHHHHHHHHTTCHHHHHHH T ss_pred cHHHHHHHHhCCCHHHHHHHHHHHHHHHcCChHHHHHHHHCCHHHHHHHHHhccCHHHHHHHHHHHHHHhCCCHHHHHHH Confidence 45556666666677888889999998866543333344445677888888877778888999999999875544333334 Q NP_000290.2 326 RRQNGIREAVSLLRR-TGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 326 l~~~IL~~Ll~lL~s-s~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ...+++..+..++.. ..+..++..++.++..++........+.. +++..++..+... .++++. T Consensus 195 ~~~~~~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~~~~~~ 259 (629) T 4R0Z_A 195 LSLLGPQILVSILREYSDHRKLIYTVVRCIRSLSVCPSNKPALISLGCLPALYVELCTA---------------KDERSQ 259 (629) T ss_dssp HHTTHHHHHHHHHHHCTTCHHHHHHHHHHHHHHTTSTTHHHHHHHTTHHHHHHHHHHHC---------------CCHHHH T ss_pred HHccHHHHHHHHHHHcCCCHHHHHHHHHHHHHHhcCcchHHHHHHCChHHHHHHHHHhC---------------CCHHHH Confidence 444567777777651 23456777888888888765443333333 5555554444321 123333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-..- +..++.+ .+++..+...+.. -+......+...|.++. T Consensus 260 ~~a~~~l~~l~~~---------------------~~~~~~~---~~~i~~l~~~l~~------~~~~~~~~a~~~l~~l~ 309 (629) T 4R0Z_A 260 TAILVAMRNLSDS---------------------ATNEENL---TQLIIKLLEIIRV------ANDGMTACACGTLSNLT 309 (629) T ss_dssp HHHHHHHHHHGGG---------------------CCTTSCC---HHHHHHHHHHTTT------CCHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHcCC---------------------cchHHHH---HHHHHHHHHHHhc------CCHHHHHHHHHHHHHHH Confidence 3333333221110 0001111 1123333322211 12222333444444444 Q NP_000290.2 484 YRLDAEVP---------TRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLN 554 (747) Q Consensus 484 ~~~~~~~~---------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~ 554 (747) ..-+.... .-..-+.....+.........+..+-... ..........+.+.++++.|+. T Consensus 310 ~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~------------~~~~~~~~~~~~~~~~~~~l~~ 377 (629) T 4R0Z_A 310 CNNTRNKQTVCSHGGIDALVTAIRRLPEVEEVTEPALCALRHCTAR------------HSLAEEAQSELRFCQAFPVILD 377 (629) T ss_dssp TTCHHHHHHHHHTTHHHHHHHHHHHCTTCHHHHHHHHHHHHHHTSS------------STTHHHHHHHHHHTTCHHHHHH T ss_pred cCCHHHHHHHHHCCHHHHHHHHHHhCCCcHHHHHHHHHHHHHhccc------------CCCcHHHHHHHhhcChHHHHHH Confidence 22111000 00000000000000000011111110000 0001111222345677888888 Q NP_000290.2 555 LMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLK------EKGLPQIARLLQS----------------GNSDVV 612 (747) Q Consensus 555 LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie------~giI~~Ll~LL~s----------------~d~eVr 612 (747) ++. +.++.++..++.+|.+++..... ...+.. .+.++.+..++.. .+..++ T Consensus 378 ~l~-~~~~~~~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~ 450 (629) T 4R0Z_A 378 QLE-TLRTPVIKAALGVIRNSALLQTN------LIELTQEQTANGHTAVSLTMDILRRAITAIEENPDIAVDGVPMWGVI 450 (629) T ss_dssp HHT-TCCHHHHHHHHHHHHHHTTSTTH------HHHHHHCCCTTCCCHHHHHHHHHHHHHHHHHHCTTCEETTEEHHHHH T ss_pred HHh-cCCHHHHHHHHHHHHHHcccchh------HHHHHhccccCCccHHHHHHHHHHHHHHhcccCCCcccCCeeHHHHH Confidence 887 46778888999999998865321 111122 3456666666643 234566 Q NP_000290.2 613 RSGASLLSNMSRHPLL-HRVMGN----------QVFPEVTRLLT------SHTGNTSNSEDILSSACYTVRNLMASQPQL 675 (747) Q Consensus 613 ~~AL~aLsnLa~~~e~-~~ll~~----------giI~~Ll~LL~------s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~ 675 (747) ..++.+|.+++..... ..+... ++++.+..++. . .++.++..++.+|.+++.. +.. T Consensus 451 ~~~~~~L~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~------~~~~v~~~a~~~L~~l~~~-~~~ 523 (629) T 4R0Z_A 451 EGAVSALHQLANHPAVAAACCDDIGQVGNPECPPFLDLLHRLLAHPRLGSM------DDEVLEREILGLLYQLSKR-PDG 523 (629) T ss_dssp HHHHHHHHHHTTSHHHHHHHHHCCCCTTCTTSCCHHHHHHHHHTCHHHHTC------SCSHHHHHHHHHHHHHTSS-HHH T ss_pred HHHHHHHHHHhCCHHHHHHHhhccccCCCCCCCcHHHHHHHHhcCcccCCC------chHHHHHHHHHHHHHHhcC-CCh Confidence 7778888888765333 222222 56777777775 3 3678889999999999854 445 Q NP_000290.2 676 AKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQ 718 (747) Q Consensus 676 ~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~~~ 718 (747) ...+...++++.|..++.+. ++.++..++.+|.++..+.... T Consensus 524 ~~~l~~~~~~~~L~~~l~~~-~~~v~~~a~~~L~~l~~~~~~~ 565 (629) T 4R0Z_A 524 ARAVESTGVSALLMESRGSQ-YKSVVTYANGVLSNLKRGDSAA 565 (629) T ss_dssp HHHHHTTTCHHHHHHHTTCS-SHHHHHHHHHHHHHHHHHHC-- T ss_pred HhHHhhccHHHHHHHHhccC-ChhHHHHHHHHHhhccCCChhh Confidence 55555666788888888766 7888999999999988766553 No 58 >4R0Z_A Protein humpback-2; armadillo repeat, cell adhesion; 2.005A {Caenorhabditis elegans} Probab=97.85 E-value=5.5e-09 Score=112.24 Aligned_cols=418 Identities=14% Similarity=0.170 Sum_probs=229.8 Template_Neff=12.300 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.+..++..++.+|..+.... .....+...++++.+...+.+.+..++..++.++.+++......... T Consensus 73 ~~~~~L~~~l~~~~~~~~~~a~~~L~~l~~~~-~~~~~~~~~~~i~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 151 (629) T 4R0Z_A 73 SFVEALMAASKSSNVNVRRNAIGALSHMSEQR-GGPLLIFRSGGLAEIIRMLYDSLESVVHYAVTTLRNLLMHVSDSRAQ 151 (629) T ss_dssp HHHHHHHHHTTCSCHHHHHHHHHHHHHHTTST-THHHHHHHHTCHHHHHHGGGCSCHHHHHHHHHHHHHHHHHCTTHHHH T ss_pred cHHHHHHHHHhCCCHHHHHHHHHHHHHHhcCC-CchHHHHhCCcHHHHHHHHhCCCHHHHHHHHHHHHHHHcCChHHHHH Confidence 45566666676677888889999999887643 22233334467777888887777788889999999887544333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...++++.+..++. ..++.++..++.++.+++... .....+.. ++++.|+.++... ..++++ T Consensus 152 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~--------------~~~~~~ 216 (629) T 4R0Z_A 152 ARALNAVEALTPHLH-KTNPKLLAQVADGLYFLLIDDAPSKITFLSLLGPQILVSILREY--------------SDHRKL 216 (629) T ss_dssp HHHTTHHHHHGGGGG-CCCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHHC--------------TTCHHH T ss_pred HHHCCHHHHHHHHHh-ccCHHHHHHHHHHHHHHhCCCHHHHHHHHHccHHHHHHHHHHHc--------------CCCHHH Confidence 444467777888776 556788889999999987543 22333333 6777777777621 012233 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..+|..-.. .+..+..+.. .+.+..++..+... .+..-...++..|.++ T Consensus 217 ~~~a~~~l~~l~~---------------------~~~~~~~~~~-~~~~~~l~~~l~~~-----~~~~~~~~a~~~l~~l 269 (629) T 4R0Z_A 217 IYTVVRCIRSLSV---------------------CPSNKPALIS-LGCLPALYVELCTA-----KDERSQTAILVAMRNL 269 (629) T ss_dssp HHHHHHHHHHHTT---------------------STTHHHHHHH-TTHHHHHHHHHHHC-----CCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhc---------------------CcchHHHHHH-CChHHHHHHHHHhC-----CCHHHHHHHHHHHHHH Confidence 3333333322110 0001111111 12222222111110 1122334445555555 Q NP_000290.2 483 SYRLDAE------VPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLM 556 (747) Q Consensus 483 ~~~~~~~------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL 556 (747) +..-+.. ++.-...+.. .+.........++.+ ....+......+.+.++++.|+.++ T Consensus 270 ~~~~~~~~~~~~~i~~l~~~l~~--~~~~~~~~a~~~l~~---------------l~~~~~~~~~~~~~~~~~~~l~~~l 332 (629) T 4R0Z_A 270 SDSATNEENLTQLIIKLLEIIRV--ANDGMTACACGTLSN---------------LTCNNTRNKQTVCSHGGIDALVTAI 332 (629) T ss_dssp GGGCCTTSCCHHHHHHHHHHTTT--CCHHHHHHHHHHHHH---------------HHTTCHHHHHHHHHTTHHHHHHHHH T ss_pred cCCcchHHHHHHHHHHHHHHHhc--CCHHHHHHHHHHHHH---------------HHcCCHHHHHHHHHCCHHHHHHHHH Confidence 4322110 0000000000 000000011111111 1111112233346778888888888 Q NP_000290.2 557 GK-SKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMG- 633 (747) Q Consensus 557 ~s-s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~- 633 (747) .. ..+..++..++.+|.+++..... ... ....+...++++.|+.++.+.++.++..++.+|.+++..... ..+.. T Consensus 333 ~~~~~~~~~~~~a~~~l~~l~~~~~~-~~~-~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~ 410 (629) T 4R0Z_A 333 RRLPEVEEVTEPALCALRHCTARHSL-AEE-AQSELRFCQAFPVILDQLETLRTPVIKAALGVIRNSALLQTNLIELTQE 410 (629) T ss_dssp HHCTTCHHHHHHHHHHHHHHTSSSTT-HHH-HHHHHHHTTCHHHHHHHHTTCCHHHHHHHHHHHHHHTTSTTHHHHHHHC T ss_pred HhCCCcHHHHHHHHHHHHHhcccCCC-cHH-HHHHHhhcChHHHHHHHHhcCCHHHHHHHHHHHHHHcccchhHHHHHhc Confidence 62 13446888999999999432110 000 123334567788899999888888999999999999876322 22211 Q NP_000290.2 634 -----NQVFPEVTRLLTSHTG----------NTSNSEDILSSACYTVRNLMASQPQLAKQYFSS----------SMLNNI 688 (747) Q Consensus 634 -----~giI~~Ll~LL~s~s~----------~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~----------giL~~L 688 (747) .++++.++.++..... ....+..++..++.+|.+++.. +.....+.+. ++++.| T Consensus 411 ~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~L~~l~~~-~~~~~~~~~~~~~~~~~~~~~~~~~l 489 (629) T 4R0Z_A 411 QTANGHTAVSLTMDILRRAITAIEENPDIAVDGVPMWGVIEGAVSALHQLANH-PAVAAACCDDIGQVGNPECPPFLDLL 489 (629) T ss_dssp CCTTCCCHHHHHHHHHHHHHHHHHHCTTCEETTEEHHHHHHHHHHHHHHHTTS-HHHHHHHHHCCCCTTCTTSCCHHHHH T ss_pred cccCCccHHHHHHHHHHHHHHhcccCCCcccCCeeHHHHHHHHHHHHHHHhCC-HHHHHHHhhccccCCCCCCCcHHHHH Confidence 3455566666532000 0002345667788888888764 4444444443 567777 Q NP_000290.2 689 INLCR------SSASPKAAEAARLLLSDMWSSKELQGVLRQQGF 726 (747) Q Consensus 689 l~LL~------s~~d~eVr~aAL~aLsnL~~~~~~~~~~~~~~~ 726 (747) ..++. +. ++.++..++.+|.+++...+....+...|. T Consensus 490 ~~~l~~~~~~~~~-~~~v~~~a~~~L~~l~~~~~~~~~l~~~~~ 532 (629) T 4R0Z_A 490 HRLLAHPRLGSMD-DEVLEREILGLLYQLSKRPDGARAVESTGV 532 (629) T ss_dssp HHHHTCHHHHTCS-CSHHHHHHHHHHHHHTSSHHHHHHHHTTTC T ss_pred HHHhcCcccCCCc-hHHHHHHHHHHHHHHhcCCChHhHHhhccH Confidence 77776 44 778899999999999977766555554444 No 59 >1XM9_A plakophilin 1 Plakophilin-1; armadillo repeat, CELL ADHESION; 2.8A {Homo sapiens} SCOP: a.118.1.24 Probab=97.84 E-value=6.1e-09 Score=106.37 Aligned_cols=350 Identities=19% Similarity=0.201 Sum_probs=191.7 Template_Neff=12.600 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .+++.+..++.+.++.++..++.++.+++.........+...++++.++.++. ..+..++..++.+|.+++... .... T Consensus 44 ~~i~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~-~~~~ 122 (457) T 1XM9_A 44 GGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKE 122 (457) T ss_dssp THHHHHHHHTTSSCHHHHHHHHHHHHHHHSSCHHHHHHHHHTTCHHHHHHHHTTCCCHHHHHHHHHHHHHHHTSS-STHH T ss_pred CHHHHHHHHhcCCCHHHHHHHHHHHHHHhhCCHHHHHHHHhcChHHHHHHHhhhCCCHHHHHHHHHHHHHHhCCH-HHHH Confidence 34566677777777888999999999988654443444445567778888876 556778888999999887632 2222 Q NP_000290.2 324 ETRRQNGIREAVSLL----------------RRTGNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVIIPFSG 385 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL----------------~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~~~~~~ 385 (747) .+. .++++.+..++ . ..++.++..++.++.+++........+.. ++++.|+.++...... T Consensus 123 ~~~-~~~~~~l~~~l~~~~~~~~~~~~~~~~~-~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~ 200 (457) T 1XM9_A 123 ELI-ADALPVLADRVIIPFSGWCDGNSNMSRE-VVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAA 200 (457) T ss_dssp HHH-HHHHHHCCCCCCHHHHTCC----------CCCHHHHHHHHHHHHHHTTSHHHHHHHTTSTTHHHHHHHHHHHHHHH T ss_pred HHH-cchHHHHHHHhccccCCCCCCCCCcccc-cCCHHHHHHHHHHHHHHccChHHHHHHHhcccHHHHHHHHHHHhhhc Confidence 222 45677777776 3 44667888899999999876544444443 5677777777642211 Q NP_000290.2 386 WCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLA-------LVPQR-ATSSRVNLSSAD------------------- 438 (747) Q Consensus 386 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-------~~~~~-~~~~~~~~~~~~------------------- 438 (747) ...++++...+..+|..-....+... ..+.+ ...+.......+ T Consensus 201 ----------~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 270 (457) T 1XM9_A 201 ----------SRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEE 270 (457) T ss_dssp ----------TCTTCTTHHHHHHHHHHHTTTHHHHSCCHHHHHHHTC----------------------------CCCCC T ss_pred ----------CcCCHHHHHHHHHHHHHHhcccccCCCcchhhhhhcccccccccccccccCcccchhccccccCCCCccc Confidence 11234444455544433211000000 00000 000000000000 Q NP_000290.2 439 ---AGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFS 515 (747) Q Consensus 439 ---~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 515 (747) .+++.+.. .+.+..|...+... -+....+.+...|.|+...- T Consensus 271 ~~~~~~~~~~~-~~~~~~l~~~l~~~-----~~~~~~~~a~~~L~~l~~~~----------------------------- 315 (457) T 1XM9_A 271 TNPKGSGWLYH-SDAIRTYLNLMGKS-----KKDATLEACAGALQNLTASK----------------------------- 315 (457) T ss_dssp SSCCGGGGGGS-HHHHHHHHHHHHHC-----CCHHHHHHHHHHHHHHTTCS----------------------------- T ss_pred CCCchhHHhhc-hhHHHHHHHHhccC-----CCHHHHHHHHHHHHHHHhcc----------------------------- Confidence 00000000 01111111111000 00000011111111111000 Q NP_000290.2 516 NKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEK 595 (747) Q Consensus 516 ~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~g 595 (747) +.... ......+.+.++++.|+.++. +.++.++..++.+|.+++.... ....+ ..+ T Consensus 316 ---------------~~~~~-~~~~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~------~~~~~-~~~ 371 (457) T 1XM9_A 316 ---------------GLMSS-GMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLSNMSRHPL------LHRVM-GNQ 371 (457) T ss_dssp ---------------SSHHH-HHHHCCCCCSCCHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSGG------GHHHH-HHH T ss_pred ---------------ccccC-CcchhhhhhcchHHHHHHHHh-cCCHHHHHHHHHHHHHHhcCHH------HHHHH-Hcc Confidence 00000 001123456778899999998 4677888999999999986432 12232 345 Q NP_000290.2 596 GLPQIARLLQSG------NSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRN 667 (747) Q Consensus 596 iI~~Ll~LL~s~------d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsn 667 (747) +++.|+.++... ++.++..++.+|.+|+.. +.. ..+...++++.|..++... .++.++..++.+|.+ T Consensus 372 ~~~~l~~~l~~~~~~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~ll~~~-----~~~~v~~~a~~~L~~ 446 (457) T 1XM9_A 372 VFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSS-----ASPKAAEAARLLLSD 446 (457) T ss_dssp THHHHHHTTTSCCSCSTTHHHHHHHHHHHHHHHHTTCTHHHHHHCCHHHHHHHHHHHHCT-----TCHHHHHHHHHHHHT T ss_pred cHHHHHHHHhcCCCCCCCCHHHHHHHHHHHHHHHhcCHHHHHHHHhccHHHHHHHHHhCC-----CCHHHHHHHHHHHHH Confidence 788888888765 678899999999999854 333 3445567788888887652 267888999999999 Q NP_000290.2 668 LMAS 671 (747) Q Consensus 668 La~~ 671 (747) |+.. T Consensus 447 l~~~ 450 (457) T 1XM9_A 447 MWSS 450 (457) T ss_dssp TSSS T ss_pred Hhhc Confidence 8864 No 60 >4I2Z_A Protein UNC-45, Heat shock protein; chaperone, myosin folding, protein filaments; 2.9A {Caenorhabditis elegans} Probab=97.84 E-value=7.3e-09 Score=122.51 Aligned_cols=69 Identities=14% Similarity=0.132 Sum_probs=41.5 Template_Neff=8.600 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVF 316 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~ 316 (747) ++.|+.++...+..++..+..++..+... ......+...+.++.|+.++.+.++..+..++.+|..++. T Consensus 648 ~~~Lv~ll~~~s~~~r~~~~~~l~~l~~~-~~~R~~iv~~G~v~~Ll~ll~~~~~~~~~~Aa~ALa~l~~ 716 (961) T 4I2Z_A 648 VPACVAVSKTESKNALELIARSLLAFAEY-EDLRGRIIAEGGTVLCLRLTKEASGEGKIKAGHAIAKLGA 716 (961) T ss_dssp HHHHHHTCCCSCSHHHHHHHHHHHTTSCS-STTHHHHTTTTHHHHHHHHHHHSCTHHHHHHHHHHHHHSS T ss_pred HHHHHHHhcCCCHHHHHHHHHHHHHHhCC-HHHHHHHHHCchHHHHHHHHhcCChHHHHHHHHHHHHHHc Confidence 44555555555566677777777777643 3344445555666777777665555566666666665543 No 61 >6SWY_5 Vacuolar import and degradation protein; Suppressed, Suppreseed, LIGASE; 3.2A { Saccharomyces cerevisiae YJM1133} Probab=97.83 E-value=7.4e-09 Score=121.91 Aligned_cols=402 Identities=11% Similarity=0.070 Sum_probs=223.3 Template_Neff=8.700 Q NP_000290.2 240 IECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLRSPN-QNVQQAAAGALRNLVFR 317 (747) Q Consensus 240 ~~~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~s~d-~eVr~~AL~aLs~La~~ 317 (747) +...+.++..+..++...+..++..++.+|..++..... ....+...++++.++.++...+ +. +..++.+|..++.. T Consensus 281 l~~~~~~~~~L~~Ll~s~~~~lr~~Al~~L~~L~~~~~~~~~~~~~~~g~l~~Li~lL~~~~~~~-~~~al~~L~~L~~~ 359 (921) T 6SWY_5 281 LRNDATFKMFVLGLLKSNDVNIRCVALKFLLQPYFTEDKKWEDTRTLEKILPYLVKSFNYDPLPW-WFDPFDMLDSLIVL 359 (921) T ss_dssp STTCSHHHHHHHHHTTCSSHHHHHHHHHHHHHHHHHSSSTTSCHHHHHHHHHHHHHTTSCSSCCT-TCCHHHHHHHHHHH T ss_pred hhcccchHHHHHHHhcCCCHHHHHHHHHHHHHHHhCCCCchhhHHHHccHHHHHHHHcCCCCCch-hchHHHHHHHHHHH Confidence 334455566666777777788899999999998865332 1233344567888888887654 44 77888888888762 Q NP_000290.2 318 S-------TTNKLETRRQNGIRE-AVSLLRRTG--------NAEIQKQLTGLLWNLSSTDEL-KEELIA--DALPVLADR 378 (747) Q Consensus 318 ~-------~~~~~~ll~~~IL~~-Ll~lL~ss~--------d~eVr~~AL~aLsnLas~~~~-~~~Lve--giLe~Lv~L 378 (747) . ......+...+.+.. +..++. .. +..++..++.++..++..... ...+.. ++++.|+.+ T Consensus 360 ~~~~~~~~~~~~~~l~~~g~i~~lL~~ll~-~~~~~~~~~~~~~v~~~al~~L~~L~~~~e~~r~~l~~~~~~l~~L~~l 438 (921) T 6SWY_5 360 YNEITPMNNPVLTTLAHTNVIFCILSRFAQ-CLSLPQHNEATLKTTTKFIKICASFAASDEKYRLLLLNDTLLLNHLEYG 438 (921) T ss_dssp HHHHSTTCCHHHHHHHHTTHHHHHHHHHHH-HHTCSSCCHHHHHHHHHHHHHHHHHHTSCHHHHHHHHTTSSHHHHHHHH T ss_pred hcccCCCCCHHHHHHHHcChHHHHHHHHHH-hcCCccCCcCCHHHHHHHHHHHHHHhCCCHHHHHHHhccccHHHHHHHH Confidence 1 111122223455565 555554 33 566778888999888875432 232333 567777777 Q NP_000290.2 379 VIIPF-------SGWC------DGNSNMS-REVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAG-RQT 443 (747) Q Consensus 379 L~~~~-------~~~~------~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~ 443 (747) +.... +.|- .+....+ ....|+++...+..+|+. ++..... ++. T Consensus 439 L~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~d~~v~~~al~~L~~---------------------Ls~~~~~lr~~ 497 (921) T 6SWY_5 439 LESHITLIQDFISLKDEIKETTTESHSMCLPPIYDHDFVAAWLLLLKS---------------------FSRSVSALRTT 497 (921) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHTTTCTTCCCCCTTHHHHHHHHHHHHH---------------------HTTCHHCCCCC T ss_pred HHhhHHHHHHHHhccHHHHhcccccccCCCCCCCCHHHHHHHHHHHHH---------------------HhCCHHHHHHH Confidence 76220 0000 0000000 011124444444444432 1111111 111 Q NP_000290.2 444 MRNYSGLIDSLMAYVQNCVA-ASRC----------DDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTG 512 (747) Q Consensus 444 ~~~~~~~~~~~~~~~~~~~~-~~~~----------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 512 (747) +.. .|++..|...++.... ...| +..-...+...|.|++..- T Consensus 498 l~~-~g~i~~Ll~lL~~~~~~~~~~~~~~~~~~~~~~~v~~~al~aL~nL~~~~-------------------------- 550 (921) T 6SWY_5 498 LKR-NKIAQLLLQILSKTYTLTKECYFAGQDFMKPEIMIMGITLGSICNFVVEF-------------------------- 550 (921) T ss_dssp SCC-HHHHHHHHHHHHHHHHHHHHCGGGCSTTTHHHHHHHHHHHHHHHHHTSSS-------------------------- T ss_pred HHH-CChHHHHHHHHHhhccchHhhhcCCcccccccHHHHHHHHHHHHHHHccC-------------------------- Confidence 111 2444444444432200 0000 1111122222222222110 Q NP_000290.2 513 CFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKS----------------------KKDATLEACAG 570 (747) Q Consensus 513 ~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss----------------------~d~eVr~~AL~ 570 (747) ......+++.|+++.|+.++... .+..++..+++ T Consensus 551 ------------------------~~~~~~l~~~gii~~L~~lL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~al~ 606 (921) T 6SWY_5 551 ------------------------SNLQSFMLRNGIIDIIEKMLTDPLFNSKKAWDDNEDERRIALQGIPVHEVKANSLW 606 (921) T ss_dssp ------------------------CTTHHHHHHTTHHHHHHHHHTSTTTCTTSCCCSSCHHHHHHSTTSCCSHHHHHHHH T ss_pred ------------------------chHHHHHHHCCHHHHHHHHhcChhhccccccCCCccHHHHHhcCCCCHHHHHHHHH Confidence 01112234556677777766521 45677889999 Q NP_000290.2 571 ALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL-----------L-HRVMG----- 633 (747) Q Consensus 571 aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e-----------~-~~ll~----- 633 (747) +|.+++..... . ....+...++++.|+.++.+.++.++..++++|.+++.... . ...+. T Consensus 607 aL~nL~~~~~~---~-~~~~l~~~~~l~~Ll~lL~~~~~~v~~~a~~~L~nL~~~~~~~~~~ll~~~~~~~~l~~~~~~~ 682 (921) T 6SWY_5 607 VLRHLMYNCQN---E-EKFQLLAKIPMNLILDFINDPCWAVQAQCFQLLRNLTCNSRKIVNILLEKFKDVEYKIDPQTGN 682 (921) T ss_dssp HHHHHTTTCCH---H-HHHHHHHHSCHHHHHTTTTCSSHHHHHHHHHHHHHHHTTCSHHHHHHHHTC------------- T ss_pred HHHHHHcCCCH---H-HHHHHHhcCCHHHHHHHHcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHhhcccceeeCcCCCC Confidence 99999875331 0 12344566888999999988888999999999999987632 1 12222 Q NP_000290.2 634 ------NQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSS-SMLNNIINLCR---------SSAS 697 (747) Q Consensus 634 ------~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~-giL~~Ll~LL~---------s~~d 697 (747) .++++.|+..+.........+..++..++++|.+++...+.....+++. ++++.|..++. .. + T Consensus 683 ~~~~~~~~ll~~L~~~L~~~~~~~~~~~~v~~~al~~L~nLa~~~~~~~~~ii~~~~il~~L~~lL~~~~~~~~~~~~-~ 761 (921) T 6SWY_5 683 KISIGSTYLFEFLAKKMRLLNPLDTQQKKAMEGILYIIVNLAAVNENKKQLVIEQDEILNIMSEILVETTTDSSSYGN-D 761 (921) T ss_dssp ------CCHHHHHHHHHHHSCTTSHHHHHHHHHHHHHHHHHHTSCHHHHHHHHHCHHHHHHHHHHHTCCSSCCSSGGG-C T ss_pred ccccccccHHHHHHHHHhccCCCchhcHHHHHHHHHHHHHHHcCCHHHHHHHHhCchHHHHHHHHHHhcCCCccccCC-C Confidence 3567777777765200000156788999999999997654544444544 67888888887 44 6 Q NP_000290.2 698 PKAAEAARLLLSDMWSSKELQGV 720 (747) Q Consensus 698 ~eVr~aAL~aLsnL~~~~~~~~~ 720 (747) +.++..++++|.+|+...+.+.. T Consensus 762 ~~v~~~al~aL~nL~~~~~~~~~ 784 (921) T 6SWY_5 762 SNLKLACLWVLNNLLWNSSVSHY 784 (921) T ss_dssp HHHHHHHHHHHHHHHCC------ T ss_pred HHHHHHHHHHHHHHHcCCCcccc Confidence 78999999999999987655433 No 62 >5IZ8_A Adenomatous polyposis coli protein, ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2; APC, ASEF, Colon CANCER, Drug; HET: PGE; 3.06A {Homo sapiens} Probab=97.83 E-value=6.6e-09 Score=103.80 Aligned_cols=297 Identities=19% Similarity=0.226 Sum_probs=179.9 Template_Neff=12.000 Q NP_000290.2 236 CSEDIECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP-----------NQNVQ 304 (747) Q Consensus 236 ~~~~~~~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~-----------d~eVr 304 (747) |.+-++-.+.........+.+.++.++..++.+|.++... ......+...++++.+..++... +..++ T Consensus 23 ~~~~~~~~~~~~~~~~~~l~~~~~~~~~~a~~~L~~l~~~-~~~~~~~~~~~~~~~L~~~l~~~~~~~~~~~~~~~~~~~ 101 (354) T 5IZ8_A 23 CWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFD-EEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLR 101 (354) T ss_dssp HHHHHHHSCSSCCCCSSCCCCGGGGTHHHHHHHHHHHHTS-HHHHHHHHHTTHHHHHHHHHHHHHHHHCSCCCHHHHHHH T ss_pred HHHHHHhcCCCCCCCCCCCCCCchHhHHHHHHHHHHccCC-HHHHHHHHHcCHHHHHHHHHHhhHHHhCCCCCCCCHHHH Confidence 4443343344444444555667778888899999988765 33333344456777777777643 67788 Q NP_000290.2 305 QAAAGALRNLVFRSTTNKLETRR-QNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST--DELKEELIA-DALPVLADRVI 380 (747) Q Consensus 305 ~~AL~aLs~La~~~~~~~~~ll~-~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~--~~~~~~Lve-giLe~Lv~LL~ 380 (747) ..++.++.+++.........+.. .++++.+..++. ..++.++..++.++.+++.. ......+.. ++++.|+.++. T Consensus 102 ~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 180 (354) T 5IZ8_A 102 RYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLK-SESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECAL 180 (354) T ss_dssp HHHHHHHHHHHTTCHHHHHHHHHCHHHHHHHHHGGG-SSCHHHHHHHHHHHHHHHTTCCHHHHHHHHHTTHHHHHHHHHH T ss_pred HHHHHHHHHHhcCCHHHHHHHHccchHHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCCChhHHHHHHHCCHHHHHHHHHH Confidence 88999999987644333333333 467777888886 55678888999999999874 222333444 77777877776 Q NP_000290.2 381 IPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSA-DAGRQTMRNYSGLIDSLMAYVQ 459 (747) Q Consensus 381 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~ 459 (747) .. .++++...+..+|.. +... +..++.+..-.|.++.|...+. T Consensus 181 ~~---------------~~~~~~~~a~~~L~~---------------------l~~~~~~~~~~~~~~~~~~~~l~~~l~ 224 (354) T 5IZ8_A 181 EV---------------KKESTLKSVLSALWN---------------------LSAHCTENKADICAVDGALAFLVGTLT 224 (354) T ss_dssp HC---------------CSHHHHHHHHHHHHH---------------------HHTSCHHHHHHHHTSTTHHHHHHHHTT T ss_pred hc---------------CCHHHHHHHHHHHHH---------------------HHcCChHhHHHHHhhccHHHHHHHHHh Confidence 42 133443333333322 1111 1122222221345555555444 Q NP_000290.2 460 NCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKG 539 (747) Q Consensus 460 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~ 539 (747) ... ...+..-.+.+..+|.+++..+. .+... T Consensus 225 ~~~--~~~~~~~~~~~~~~L~~l~~~~~-----------------------------------------------~~~~~ 255 (354) T 5IZ8_A 225 YRS--QTNTLAIIESGGGILRNVSSLIA-----------------------------------------------TNEDH 255 (354) T ss_dssp CCC--TTSCCHHHHHHHHHHHHHHHHHH-----------------------------------------------TCHHH T ss_pred hcC--CCCcHHHHHHHHHHHHHHHHHhc-----------------------------------------------CCHHH Confidence 210 01113334555555666541100 01112 Q NP_000290.2 540 SGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLL 619 (747) Q Consensus 540 ~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aL 619 (747) ...+.+.++++.|+.++. ..++.++..++.+|.+++...+. ....+.+.++++.|+.++.+.++.++..++.+| T Consensus 256 ~~~l~~~~~~~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L 329 (354) T 5IZ8_A 256 RQILRENNCLQTLLQHLK-SHSLTIVSNACGTLWNLSARNPK-----DQEALWDMGAVSMLKNLIHSKHKMIAMGSAAAL 329 (354) T ss_dssp HHHHHTTTHHHHHHHTTT-CSCHHHHHHHHHHHHHHSSSCHH-----HHHHHHTTTHHHHHHHHSSCSSHHHHHHHHHHH T ss_pred HHHHHHCCHHHHHHHHhh-cCCHHHHHHHHHHHHHHHccCHH-----HHHHHHhCCHHHHHHHHHhccCHHHHHHHHHHH Confidence 223356678888888887 46777888999999999874332 233445678899999999888888999999999 Q NP_000290.2 620 SNMSRH 625 (747) Q Consensus 620 snLa~~ 625 (747) .+++.. T Consensus 330 ~~l~~~ 335 (354) T 5IZ8_A 330 RNLMAN 335 (354) T ss_dssp HHHHTT T ss_pred HHHHcc Confidence 999876 No 63 >3IFQ_A plakoglobin, E-cadherin; armadillo repeat, Cardiomyopathy, Cell adhesion; HET: SO4; 2.8A {Homo sapiens} Probab=97.83 E-value=6.4e-09 Score=107.67 Aligned_cols=374 Identities=16% Similarity=0.150 Sum_probs=218.5 Template_Neff=13.100 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) ..+++.+...+.+.++.++..++.++..+..............++++.+...+. ..++.++..++.++..+..... .. T Consensus 18 ~~~~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~-~~ 96 (553) T 3IFQ_A 18 TRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHRE-GL 96 (553) T ss_dssp HHTHHHHHHHHTCSCHHHHHHHHHHHHHHTTSHHHHHHHHTCHHHHHHHHHHHTTCCCHHHHHHHHHHHHHHTTSHH-HH T ss_pred cCcHHHHHHHhcCCCHHHHHHHHHHHHHHhCCHHHHHHHhcCchHHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCHH-HH Confidence 345666777777777888888999998887653221111112356666777666 4556778888888888775432 22 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDP 400 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~ 400 (747) ..+...+.++.+...+. +.++.++..++.++..++..... ...+.. ++++.|..++... ++ T Consensus 97 ~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~ 159 (553) T 3IFQ_A 97 LAIFKSGGIPALVRMLS-SPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKN----------------NP 159 (553) T ss_dssp HHHHHTTHHHHHHHGGG-CCCHHHHHHHHHHHHHHHHHCTTHHHHHHHTTGGGGTGGGGGSS----------------CH T ss_pred HHHHHcCcHHHHHHHcc-CCCHHHHHHHHHHHHHHhcCChHHHHHHHhcCHHHHHHHHHhcC----------------CH Confidence 22333456777777776 55677888888888888764332 222222 6666676666531 33 Q NP_000290.2 401 EVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLH 480 (747) Q Consensus 401 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 480 (747) ++...+..+|..-... .+ ..+..+ --.++++.|...+... .+......++..|. T Consensus 160 ~~~~~a~~~l~~l~~~------~~--------------~~~~~~-~~~~~~~~l~~~l~~~-----~~~~~~~~a~~~l~ 213 (553) T 3IFQ_A 160 KFLAITTDCLQLLAYG------NQ--------------ESKLII-LANGGPQALVQIMRNY-----SYEKLLWTTSRVLK 213 (553) T ss_dssp HHHHHHHHHHHHHHTT------CH--------------HHHHHH-HHTTHHHHHHHHHHHC-----CCHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHcC------CH--------------HHHHHH-HHCCHHHHHHHHHhcC-----CcHHHHHHHHHHHH Confidence 4444444433321100 00 000000 0113344443333210 01111222223333 Q NP_000290.2 481 NLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSK 560 (747) Q Consensus 481 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~ 560 (747) +++..- .....+.+.++++.++.++. +. T Consensus 214 ~l~~~~---------------------------------------------------~~~~~~~~~~~~~~l~~~l~-~~ 241 (553) T 3IFQ_A 214 VLSVCP---------------------------------------------------SNKPAIVEAGGMQALGKHLT-SN 241 (553) T ss_dssp HHTTST---------------------------------------------------THHHHHHHTTHHHHHHGGGG-SS T ss_pred HHhCCc---------------------------------------------------chHHHHHHCchHHHHHHHHh-cC Confidence 322100 00112234567888888887 46 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVFP 638 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI~ 638 (747) ++.++..++.+|.+++..... ... ..++++.+..++.+.++.++..++.+|.+++... .. ..+...++++ T Consensus 242 ~~~~~~~a~~~l~~l~~~~~~------~~~--~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~ 313 (553) T 3IFQ_A 242 SPRLVQNCLWTLRNLSDVATK------QEG--LESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVE 313 (553) T ss_dssp CHHHHHHHHHHHHHHHTTCTT------CSC--CHHHHHHHHTTTTCCCHHHHHHHHHHHHHHTTTCHHHHHHHTTTTHHH T ss_pred CHHHHHHHHHHHHHhCChhHH------HHH--HHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHccHHH Confidence 778888999999999865321 111 2467888888888888889999999999998763 22 2334455777 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ---LAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e---~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .+...+... ..++.++..++.+|.+++...+. ....+...+.++.+..++.+..++.++..++.+|.+++... T Consensus 314 ~l~~~l~~~----~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~ 389 (553) T 3IFQ_A 314 ALIHAILRA----GDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCP 389 (553) T ss_dssp HHHHHHHHH----TTCHHHHHHHHHHHHHHTSSSTTHHHHHHHHHTTTHHHHHHHGGGCTTCHHHHHHHHHHHHHHTTSG T ss_pred HHHHHHHHc----CCChHhHHHHHHHHHHHhcCCChHHHHHHHHHHcchHHHHHHHHcCCCChHHHHHHHHHHHHHhcCc Confidence 777766531 02567888999999999875332 11223344567888888876523788899999999998876 Q NP_000290.2 716 ELQGVLRQQG 725 (747) Q Consensus 716 ~~~~~~~~~~ 725 (747) +....+...| T Consensus 390 ~~~~~~~~~~ 399 (553) T 3IFQ_A 390 ANHAPLQEAA 399 (553) T ss_dssp GGHHHHHHTT T ss_pred ccHHHHHHcc Confidence 6554444333 No 64 >4I2W_A Protein UNC-45, Heat shock 70; chaperone, myosin folding, protein filaments; 3.6A {Caenorhabditis elegans} Probab=97.83 E-value=7.9e-09 Score=122.23 Aligned_cols=70 Identities=14% Similarity=0.133 Sum_probs=42.2 Template_Neff=8.600 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVF 316 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~ 316 (747) +++.|+.++...+..++..+..++..+... ......+...+.++.|+.++.+.++..+..++.+|..++. T Consensus 647 ~~~~Lv~ll~~~s~~~r~~~~~~l~~l~~~-~~~R~~ivq~g~~~~Ll~ll~~~~~~~~~~Aa~ALa~l~~ 716 (961) T 4I2W_A 647 AVPACVAVSKTESKNALELIARSLLAFAEY-EDLRGRIIAEGGTVLCLRLTKEASGEGKIKAGHAIAKLGA 716 (961) T ss_dssp SSHHHHHTTCCCCSHHHHHHHHHHHTTSSS-STTTTTTTTSSHHHHHHHHHHHSTTHHHHHHHHHHHTTSS T ss_pred CHHHHHHHhcCCCHHHHHHHHHHHHHHhCC-HHHHHHHHHCchHHHHHHHHhcCChHHHHHHHHHHHHHHc Confidence 344555555555566677777777777643 3344445555666777776665555566666666666653 No 65 >4R10_A Protein humpback-2, Cadherin-related hmr-1; armadillo repeat, cell adhesion, phosphorylation; HET: SEP; 2.3A {Caenorhabditis elegans} Probab=97.79 E-value=8.7e-09 Score=108.23 Aligned_cols=398 Identities=14% Similarity=0.146 Sum_probs=205.5 Template_Neff=12.700 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++.........+...++++.+...+...++.++..++.++..++.........+ T Consensus 115 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 194 (572) T 4R10_A 115 GLAEIIRMLYDSLESVVHYAVTTLRNLLMHVSDSRAQARALNAVEALTPHLHKTNPKLLAQVADGLYFLLIDDAPSKITF 194 (572) T ss_dssp THHHHHHGGGCSCHHHHHHHHHHHHHHHHHCTHHHHHHHHTTHHHHHGGGGGCCCHHHHHHHHHHHHHHHTTCHHHHHHH T ss_pred cHHHHHHHHhCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHHhcCCHHHHHHHHHHHHHHHCCChHHHHHH Confidence 34555666666677888889999998866443333334444677778888877778888899999988875443333333 Q NP_000290.2 326 RRQNGIREAVSLLRR-TGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 326 l~~~IL~~Ll~lL~s-s~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ...+++..+...+.. ..+..++..++.++..++........+.. ++++.++..+... .++++. T Consensus 195 ~~~~~~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~~~~~~ 259 (572) T 4R10_A 195 LSLLGPQILVSILREYSDHRKLIYTVVRCIRSLSVCPSNKPALISLGCLPALYVELCTA---------------KDERSQ 259 (572) T ss_dssp HHTTHHHHHHHHHHHCTTCHHHHHHHHHHHHHHTTSTTHHHHHHHTTHHHHHHHHHTTC---------------CSHHHH T ss_pred HhccHHHHHHHHHHHCCCCHHHHHHHHHHHHHHhcCcchHHHHHhCCcHHHHHHHHhcC---------------CCHHHH Confidence 344566667766641 23456778888888888765443333333 5555554433321 123333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-.. ....++.+ .+++..+...++. -+..-...+...|.++. T Consensus 260 ~~a~~~l~~l~~---------------------~~~~~~~~---~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 309 (572) T 4R10_A 260 TAILVAMRNLSD---------------------SATNEENL---TQLIIKLLEIIRV------ANDGMTACACGTLSNLT 309 (572) T ss_dssp HHHHHHHHHHGG---------------------GCTTCSCC---HHHHHHHHHHHHH------CCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHcC---------------------ChHHHHHH---HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHH Confidence 333333322110 00011111 1123333322211 12222333444444444 Q NP_000290.2 484 YRLDAEVP---------TRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLN 554 (747) Q Consensus 484 ~~~~~~~~---------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~ 554 (747) ..-+.... .-...+.....+.........+..+-.. . ...+......+...++++.++. T Consensus 310 ~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~----~--------~~~~~~~~~~~~~~~~~~~l~~ 377 (572) T 4R10_A 310 CNNTRNKQTVCSHGGIDALVTAIRRLPEVEEVTEPALCALRHCTA----R--------HSLAEEAQSELRFCQAFPVILD 377 (572) T ss_dssp SSCHHHHHHHHHTTHHHHHHHHHHHSTTCHHHHHHHHHHHHHHTS----S--------STTHHHHHHHHHHTTHHHHHHH T ss_pred cCCHHHHHHHHHCcHHHHHHHHHHhCCCcHHHHHHHHHHHHHhhc----c--------CCCcHHHHHHHhhCChHHHHHH Confidence 32111000 0000000000000000000000000000 0 0000111122245567788888 Q NP_000290.2 555 LMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLK------EKGLPQIARLLQS----------------GNSDVV 612 (747) Q Consensus 555 LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie------~giI~~Ll~LL~s----------------~d~eVr 612 (747) ++. +.+..++..++.+|.+++..... ...+.+ .++++.+..++.. .++.++ T Consensus 378 ~l~-~~~~~v~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~ 450 (572) T 4R10_A 378 QLE-TLRTPVIKAALGVIRNSALLQTN------LIELTQEQTANGHTAVSLTMDILRRAITAIEENPDIAVDGVPMWGVI 450 (572) T ss_dssp HHT-TCCHHHHHHHHHHHHHHHTSHHH------HHHHHHCCCTTCCCHHHHHHHHHHHHHHHHHHCTTCEETTEEHHHHH T ss_pred HHh-cCCHHHHHHHHHHHHHHhccchh------HHHHHHHhhhCCCCcHHHHHHHHHHHHHhcccCcchhccCccHHHHH Confidence 887 36667777888888888764221 111122 2344555555432 234566 Q NP_000290.2 613 RSGASLLSNMSRHPLLH-RVMGN----------QVFPEVTRLL------TSHTGNTSNSEDILSSACYTVRNLMASQPQL 675 (747) Q Consensus 613 ~~AL~aLsnLa~~~e~~-~ll~~----------giI~~Ll~LL------~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~ 675 (747) ..++.+|.+++...... .+... ++++.+..++ .. .++.++..++.+|.+++.. +.. T Consensus 451 ~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~------~~~~v~~~a~~~l~~l~~~-~~~ 523 (572) T 4R10_A 451 EGAVSALHQLANHPAVAAACCDDIGQVGNPECPPFLDLLHRLLAHPRLGSM------DDEVLEREILGLLYQLSKR-PDG 523 (572) T ss_dssp HHHHHHHHHHTTSHHHHHHHHHCCCCTTCTTSCCHHHHHHHHHHSHHHHSC------SCSHHHHHHHHHHHHHTSS-HHH T ss_pred HHHHHHHHHHhCCHHHHHHHhccccCCCCCCCccHHHHHHHHHhCcccCCC------ChHHHHHHHHHHHHHHhcC-Cch Confidence 77788888877653221 11111 4666666666 33 3677888888888888865 344 Q NP_000290.2 676 AKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 676 ~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ...+...++++.|..++.+. ++.++..++.+|.++.... T Consensus 524 ~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~L~~l~~~~ 562 (572) T 4R10_A 524 ARAVESTGVSALLMESRGSQ-YKSVVTYANGVLSNLKRGD 562 (572) T ss_dssp HHHHHTTTTHHHHHHHTTCS-CHHHHHHHHHHHHHHHHHH T ss_pred hhHHHHcChhhHHhHhhCCC-CchHHHHHHHHHHHhhcCC Confidence 44455566778888888766 7788888888888887654 No 66 >5T94_B Guanine nucleotide exchange factor SRM1; Nuclear Import, Importin alpha, RCC1; 2.631A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=97.78 E-value=9.3e-09 Score=108.50 Aligned_cols=159 Identities=19% Similarity=0.225 Sum_probs=117.7 Template_Neff=12.200 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) ...++++.|+.++. ..++.++..++.+|.+++..... ....+...++++.|..++.+.++.++..++.+|.+++ T Consensus 254 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~ 327 (542) T 5T94_B 254 VVSQALPTLAKLIY-SMDTETLVDACWAISYLSDGPQE-----AIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIV 327 (542) T ss_dssp HHGGGHHHHHHHTT-CCCHHHHHHHHHHHHHHSSSSHH-----HHHHHHHTTCHHHHHHTTSCSSHHHHHHHHHHHHHHT T ss_pred HHhcHHHHHHHHHh-cCCHHHHHHHHHHHHHHcCCCHH-----HHHHHHhCCHHHHHHHHhcCCCHHHHHHHHHHHHHHH Confidence 34556777777777 46677888899999988865332 2333345668888888888888889999999999998 Q NP_000290.2 624 RHPL-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAA 701 (747) Q Consensus 624 ~~~e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr 701 (747) .... . ......++++.|..++.+ .++.++..++++|.+++...+.....+...++++.|+.++.+. ++.++ T Consensus 328 ~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~ 400 (542) T 5T94_B 328 TGNDLQTQVVINAGVLPALRLLLSS------PKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVA-EYKTK 400 (542) T ss_dssp TSCHHHHHHHHHTTHHHHHHHHTTC------SSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHHHHHS-CHHHH T ss_pred cCCHHHHHHHHHCChHHHHHHHhhC------CCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCchHHHHHHHHcC-CHHHH Confidence 7632 2 233445678888888866 3678889999999999876555555566666788888888766 77888 Q NP_000290.2 702 EAARLLLSDMWSSK 715 (747) Q Consensus 702 ~aAL~aLsnL~~~~ 715 (747) ..++.+|.+++... T Consensus 401 ~~a~~~l~~l~~~~ 414 (542) T 5T94_B 401 KEACWAISNASSGG 414 (542) T ss_dssp HHHHHHHHHHHGGG T ss_pred HHHHHHHHHHHcCC Confidence 99999999888764 No 67 >6KBN_A Vacuolar protein 8, Autophagy-related protein; Armadillo repeats, complex, PROTEIN BINDING-PROTEIN; 3.2A {Saccharomyces cerevisiae} Probab=97.78 E-value=9.2e-09 Score=107.80 Aligned_cols=358 Identities=22% Similarity=0.258 Sum_probs=207.0 Template_Neff=12.700 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+....... ....+++.+...+.+.++.++..++.++..++..... ... T Consensus 32 ~~i~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~----~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~-~~~ 106 (563) T 6KBN_A 32 GPLKALTTLVYSDNLNLQRSAALAFAEITEKYVRQ----VSREVLEPILILLQSQDPQIQVAACAALGNLAVNNEN-KLL 106 (563) T ss_dssp CTHHHHHHHHTTCCHHHHHHHHHHHHHHHHHCCCC----CCHHHHHHHHHHHSSCCHHHHHHHHHHHHHHTTSHHH-HHH T ss_pred CHHHHHHHHhcCCCHHHHHHHHHHHHHHhhhhHHH----hccchHHHHHHHhcCCCHHHHHHHHHHHHHHHcCcch-HHH Confidence 34566666676677788888888888876532211 2245666777777777777888888888887754322 222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ....+.++.+...+. ..++.++..++.++..++........+.. ++++.|..++... ++++- T Consensus 107 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~v~ 169 (563) T 6KBN_A 107 IVEMGGLEPLINQMM-GDNVEVQCNAVGCITNLATRDDNKHKIATSGALIPLTKLAKSK----------------HIRVQ 169 (563) T ss_dssp HHHHTCHHHHHHHHH-SSCHHHHHHHHHHHHHTTCSHHHHHHHHTTTTHHHHHHHTTCS----------------SHHHH T ss_pred HHHCCcHHHHHHHhh-CCCHHHHHHHHHHHHHHhCCCchHHHHHhcChHHHHHHHccCC----------------CHHHH Confidence 233355666777665 45667788888888888765433222222 5566666655421 23333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-. .....+..+. ..++++.+...++. -+..-...+...|.++. T Consensus 170 ~~a~~~l~~l~---------------------~~~~~~~~~~-~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 221 (563) T 6KBN_A 170 RNATGALLNMT---------------------HSEENRKELV-NAGAVPVLVSLLSS------TDPDVQYYCTTALSNIA 221 (563) T ss_dssp HHHHHHHHHTT---------------------SSHHHHHHHH-TTTCHHHHHHHTTC------SSHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHh---------------------CCHHHHHHHH-HCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHh Confidence 33333322110 0000111111 12344444444331 11222223333333332 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ...+ . .........++++.+..++. +.++. T Consensus 222 ~~~~------------------------------------------------~-~~~~~~~~~~~~~~l~~~l~-~~~~~ 251 (563) T 6KBN_A 222 VDEA------------------------------------------------N-RKKLAQTEPRLVSKLVSLMD-SPSSR 251 (563) T ss_dssp TSHH------------------------------------------------H-HHHHHHHCSSHHHHHHHHTT-CSCHH T ss_pred CCHH------------------------------------------------H-HHHHHhhchhHHHHHHHHhc-CCCHH Confidence 2000 0 00000012346777888887 46777 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTR 642 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~ 642 (747) ++..++.+|.+++..... ...+...++++.+..++.+.++.++..++.+|.+++..... ......++++.+.. T Consensus 252 ~~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~ 325 (563) T 6KBN_A 252 VKCQATLALRNLASDTSY------QLEIVRAGGLPHLVKLIQSDSIPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVR 325 (563) T ss_dssp HHHHHHHHHHHHTTSHHH------HHHHHHTTCHHHHHHHHTCSCHHHHHHHHHHHHHHHTSGGGHHHHHHTTCHHHHHT T ss_pred HHHHHHHHHHHHhCChhH------HHHHHHCCcHHHHHHHHhCCCHHHHHHHHHHHHHHhcCcchHHHHHHCCcHHHHHH Confidence 888999999998875321 22334567888888888888888999999999999876433 23344567788888 Q NP_000290.2 643 LLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 643 LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++... .++.++..++.+|.+++...+.....+...++++.+..++.+. ++.++..++.++..+... T Consensus 326 ~l~~~-----~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~l~~l~~~ 391 (563) T 6KBN_A 326 LLDYK-----DSEEIQCHAVSTLRNLAASSEKNRKEFFESGAVEKCKELALDS-PVSVQSEISACFAILALA 391 (563) T ss_dssp TTTCT-----TCHHHHHHHHHHHHHHHHHCSTTHHHHHHTTHHHHHHHHHTSS-CHHHHHHHHHHHHHHTTC T ss_pred HhCCC-----CCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHhCC-CHHHHHHHHHHHHHHhcC Confidence 87652 2478888999999999876444444455555677777776654 556666666666655543 No 68 >6KBN_C Vacuolar protein 8, Autophagy-related protein; Armadillo repeats, complex, PROTEIN BINDING-PROTEIN; 3.2A {Saccharomyces cerevisiae} Probab=97.78 E-value=9.2e-09 Score=107.80 Aligned_cols=358 Identities=22% Similarity=0.258 Sum_probs=206.7 Template_Neff=12.700 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+....... ....+++.+...+.+.++.++..++.++..++..... ... T Consensus 32 ~~i~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~----~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~-~~~ 106 (563) T 6KBN_C 32 GPLKALTTLVYSDNLNLQRSAALAFAEITEKYVRQ----VSREVLEPILILLQSQDPQIQVAACAALGNLAVNNEN-KLL 106 (563) T ss_dssp -CHHHHHHHHTTCCHHHHHHHHHHHHHHHHHCCCC----CCHHHHHHHHHHHCCSCHHHHHHHHHHHHHHTTSHHH-HHH T ss_pred CHHHHHHHHhcCCCHHHHHHHHHHHHHHhhhhHHH----hccchHHHHHHHhcCCCHHHHHHHHHHHHHHHcCcch-HHH Confidence 34566666676677788888888888876532211 2245666777777777777888888888887754322 222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ....+.++.+...+. ..++.++..++.++..++........+.. ++++.|..++... ++++- T Consensus 107 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~v~ 169 (563) T 6KBN_C 107 IVEMGGLEPLINQMM-GDNVEVQCNAVGCITNLATRDDNKHKIATSGALIPLTKLAKSK----------------HIRVQ 169 (563) T ss_dssp HHHTSCSHHHHHHTT-SSCHHHHHHHHHHHHHTTCSHHHHHHHHGGGCHHHHHHHTTSS----------------SHHHH T ss_pred HHHCCcHHHHHHHhh-CCCHHHHHHHHHHHHHHhCCCchHHHHHhcChHHHHHHHccCC----------------CHHHH Confidence 233355666777665 45667788888888888765433222222 5566666655421 23333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-. .....+..+. ..++++.+...++. -+..-...+...|.++. T Consensus 170 ~~a~~~l~~l~---------------------~~~~~~~~~~-~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 221 (563) T 6KBN_C 170 RNATGALLNMT---------------------HSEENRKELV-NAGAVPVLVSLLSS------TDPDVQYYCTTALSNIA 221 (563) T ss_dssp HHHHHHHHHHT---------------------SSHHHHHHHH-TTTCHHHHHHHTTC------SSHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHh---------------------CCHHHHHHHH-HCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHh Confidence 33333322110 0000111111 12344444444331 11222223333333332 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ...+ . .........++++.+..++. +.++. T Consensus 222 ~~~~------------------------------------------------~-~~~~~~~~~~~~~~l~~~l~-~~~~~ 251 (563) T 6KBN_C 222 VDEA------------------------------------------------N-RKKLAQTEPRLVSKLVSLMD-SPSSR 251 (563) T ss_dssp TSHH------------------------------------------------H-HHHHHHSSTTHHHHHHHHTT-CSSHH T ss_pred CCHH------------------------------------------------H-HHHHHhhchhHHHHHHHHhc-CCCHH Confidence 2000 0 00000012346777888887 46777 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTR 642 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~ 642 (747) ++..++.+|.+++..... ...+...++++.+..++.+.++.++..++.+|.+++..... ......++++.+.. T Consensus 252 ~~~~a~~~l~~l~~~~~~------~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~ 325 (563) T 6KBN_C 252 VKCQATLALRNLASDTSY------QLEIVRAGGLPHLVKLIQSDSIPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVR 325 (563) T ss_dssp HHHHHHHHHHHHTTSHHH------HHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHHTSGGGHHHHHHTTCHHHHHH T ss_pred HHHHHHHHHHHHhCChhH------HHHHHHCCcHHHHHHHHhCCCHHHHHHHHHHHHHHhcCcchHHHHHHCCcHHHHHH Confidence 888999999998875321 22334567888888888888888999999999999876433 23344567788888 Q NP_000290.2 643 LLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 643 LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++... .++.++..++.+|.+++...+.....+...++++.+..++.+. ++.++..++.++..+... T Consensus 326 ~l~~~-----~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~l~~l~~~ 391 (563) T 6KBN_C 326 LLDYK-----DSEEIQCHAVSTLRNLAASSEKNRKEFFESGAVEKCKELALDS-PVSVQSEISACFAILALA 391 (563) T ss_dssp HTTCS-----SCHHHHHHHHHHHHHHHHHCSTTSHHHHTTCHHHHHHHHHTSS-CHHHHHHHHHHHHHHTTC T ss_pred HhCCC-----CCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHhCC-CHHHHHHHHHHHHHHhcC Confidence 87652 2478888999999999876444444455555677777776654 556666666666655543 No 69 >2Z6G_A B-catenin; Full-Length, Beta-Catenin, CELL ADHESION; 3.4A {Danio rerio} Probab=97.75 E-value=1.2e-08 Score=115.80 Aligned_cols=373 Identities=17% Similarity=0.153 Sum_probs=224.6 Template_Neff=10.700 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) ..+++.+...+.+.++.++..++.+|..+..............+++..+...+.+ .+..++..++.+|..+..... .. T Consensus 149 ~~~l~~L~~lL~~~~~~vr~~a~~~L~~l~~~~~~~~~~~~~~~~i~~L~~~L~~~~~~~vr~~a~~~L~~l~~~~~-~~ 227 (780) T 2Z6G_A 149 TRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTSGTLHNLSHHRE-GL 227 (780) T ss_pred cChHHHHHHHccCCCHHHHHHHHHHHHHHhCChHHHHHHHhCCCHHHHHHHHhcCCCCHHHHHHHHHHHHHHhCCHH-HH Confidence 3566777777877788899999999998876532221111122466777777765 677888889999988875422 22 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELI-A-DALPVLADRVIIPFSGWCDGNSNMSREVVDP 400 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lv-e-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~ 400 (747) ..+...++++.+..++. ..++.++..++.+|..++.........+ . ++++.|+.++..+ ++ T Consensus 228 ~~~~~~~~i~~L~~lL~-~~~~~v~~~al~~L~~l~~~~~~~~~~~~~~~~~~~L~~lL~~~----------------~~ 290 (780) T 2Z6G_A 228 LAIFKSGGIPALVNMLG-SPVDSVLFHAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKT----------------NV 290 (780) T ss_pred HHHHHCCcHHHHHHHhC-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCC----------------CH Confidence 22333567778888886 5567788899999998886533222222 2 6677777766531 34 Q NP_000290.2 401 EVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLH 480 (747) Q Consensus 401 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 480 (747) ++-..+..+|..-.... ...+..+. ..+++..|...+... .+.+-.+.++.+|. T Consensus 291 ~v~~~a~~~L~~l~~~~--------------------~~~~~~~~-~~~~~~~L~~~l~~~-----~~~~v~~~a~~~L~ 344 (780) T 2Z6G_A 291 KFLAITTDCLQILAYGN--------------------QESKLIIL-ASGGPQALVNIMRTY-----TYEKLLWTTSRVLK 344 (780) T ss_pred HHHHHHHHHHHHHHcCC--------------------HHHHHHHH-HCCcHHHHHHHhCCC-----CCHHHHHHHHHHHH Confidence 44455555554311100 00011110 123444444333221 01112222222332 Q NP_000290.2 481 NLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSK 560 (747) Q Consensus 481 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~ 560 (747) +++... .....+.+.++++.|+.++. +. T Consensus 345 ~l~~~~---------------------------------------------------~~~~~~~~~~~l~~L~~~l~-~~ 372 (780) T 2Z6G_A 345 VLSVCS---------------------------------------------------SNKPAIVEAGGMQALGLHLT-DP 372 (780) T ss_pred HHhCCH---------------------------------------------------HHHHHHHHCCHHHHHHHHcc-CC Confidence 222100 00112245667888888887 46 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFP 638 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~ 638 (747) +..++..++.+|.+++..... .. ...++++.|+.++.+.+..++..++.+|.+++.. ... ..+...++++ T Consensus 373 ~~~v~~~al~~L~~l~~~~~~------~~--~~~~~l~~L~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~l~ 444 (780) T 2Z6G_A 373 SQRLVQNCLWTLRNLSDAATK------QE--GMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIE 444 (780) T ss_pred CHHHHHHHHHHHHHHhcCCCC------HH--HHcChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHH Confidence 778888999999999864321 11 1256788888888888888999999999999876 222 2334456777 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL---AKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~---~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .|+..+... ..++.++..++.+|.+++...+.. ...+...++++.|+.++....+..++..++.+|.+++... T Consensus 445 ~L~~~l~~~----~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~i~~L~~ll~~~~~~~v~~~a~~~L~~l~~~~ 520 (780) T 2Z6G_A 445 ALVRTVLRA----GDREDITEPAICALRHLTSRHQDAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCP 520 (780) T ss_pred HHHHHHhcC----CCCHHHHHHHHHHHHHHHcCCccHHHHHHHHHHCCcHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCH Confidence 777766521 035678899999999998653221 2223334567888888875435678899999999988776 Q NP_000290.2 716 ELQGVLRQQ 724 (747) Q Consensus 716 ~~~~~~~~~ 724 (747) +....+... T Consensus 521 ~~~~~~~~~ 529 (780) T 2Z6G_A 521 ANHAPLREQ 529 (780) T ss_pred HHHHHHHhC Confidence 654444333 No 70 >5EWP_B Uncharacterized protein; translocation and attachment of rhoptries; 1.8A {Plasmodium falciparum Santa Lucia} Probab=97.73 E-value=1.3e-08 Score=96.81 Aligned_cols=118 Identities=16% Similarity=0.189 Sum_probs=81.2 Template_Neff=11.800 Q NP_000290.2 263 AIGAYYIQHTCFQ--DESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRR 340 (747) Q Consensus 263 ~sAL~aLsnLs~~--~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll~lL~s 340 (747) ..++.++.++... .......+...+.++.+..++...+..++..++.++.+++.........+...+.++.++.++. T Consensus 60 ~~~~~~l~~l~~~~~~~~~~~~~~~~g~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~- 138 (252) T 5EWP_B 60 ALSATQLAILASKENEPHYKDAIREANGIAVFINLLKSHELDRVHAAVVALSFLSVDNVKNCICMFESGALPYLISGMK- 138 (252) T ss_dssp HHHHHHHHHHHTCTTCTHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTTCHHHHHHHHHTTCHHHHHHHTT- T ss_pred HHHHHHHHHHhcCCCCHHHHHHHHHcccHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHhh- Confidence 4677788777754 2333344445567788888887777778889999999988654444444444567777888776 Q NP_000290.2 341 TGNAEIQKQLTGLLWNLSST-DELKEELIA-DALPVLADRVII 381 (747) Q Consensus 341 s~d~eVr~~AL~aLsnLas~-~~~~~~Lve-giLe~Lv~LL~~ 381 (747) ..++.++..++.++.+++.. ......+.+ ++++.|+.++.. T Consensus 139 ~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~ 181 (252) T 5EWP_B 139 SNIDGMKAACAQTCRNIFVLDKKYKKEFLKLGGITQLVNLLEL 181 (252) T ss_dssp CSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHTTSC T ss_pred CCCHHHHHHHHHHHHHHHhcCHHHHHHHHHCChHHHHHHHhcC Confidence 55678889999999999864 333334444 777888877764 No 71 >5XGC_A Rap1 GTPase-GDP dissociation stimulator 1; armadillo GEF, ONCOPROTEIN; 2.1A {Homo sapiens} Probab=97.72 E-value=1.3e-08 Score=103.51 Aligned_cols=358 Identities=19% Similarity=0.180 Sum_probs=198.3 Template_Neff=13.200 Q NP_000290.2 257 QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVS 336 (747) Q Consensus 257 sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll~ 336 (747) .++.++..++.++..+.... .....+...++++.+...+.+.++.++..++.++..++...+.....+...++++.+.. T Consensus 5 ~~~~~~~~a~~~l~~l~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~ 83 (503) T 5XGC_A 5 SQSSCKAKVANIIAEVAKNE-FMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVK 83 (503) T ss_dssp -------------------C-CCCCCSSCHHHHHHHHHHTTCSCHHHHHHHHHHHHHSCCCSHHHHHHHHHTTHHHHHHH T ss_pred chHHHHHHHHHHHHHHhcCh-hhhhhhhhcCcHHHHHHHHcCCCHHHHHHHHHHHHHHHcCCchHHHHHHHCChHHHHHH Confidence 34567777888888887642 22333444567788888888778888999999999988654333333444567778888 Q NP_000290.2 337 LLRRT-GNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRL 414 (747) Q Consensus 337 lL~ss-~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 414 (747) .+... .++.++..++.++..++........+.. ++++.|+.++.... ++++-..+..+|..- T Consensus 84 ~l~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~~---------------~~~~~~~a~~~l~~l- 147 (503) T 5XGC_A 84 LLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQI---------------EHDKREMIFEVLAPL- 147 (503) T ss_dssp HHHHTTTCHHHHHHHHHHHHHHTTSHHHHHHHTTTTHHHHHHHHHHHCC---------------CHHHHHHHHHHHHHH- T ss_pred HHhccCCCHHHHHHHHHHHHHHHccHHHHHHHhcCCHHHHHHHHHHhcC---------------ChhHHHHHHHHHHHH- Confidence 87622 3677888999999998876443333333 67777777776421 233333333333211 Q NP_000290.2 415 GMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRY 494 (747) Q Consensus 415 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 494 (747) ...+..+..+. -.|.+..++..+... ++.........+.+... T Consensus 148 --------------------~~~~~~~~~~~-~~~~~~~l~~~l~~~------~~~~~~~~~~~l~~~~~---------- 190 (503) T 5XGC_A 148 --------------------AENDAIKLQLV-EAGLVECLLEIVQQK------VDSDKEDDITELKTGSD---------- 190 (503) T ss_dssp --------------------TTSHHHHHHHH-HTTHHHHHHHHHHHH------TTCCCHHHHHHHHHHHH---------- T ss_pred --------------------HcCHHHHHHHH-HCCHHHHHHHHHHhc------CCCCCHHHHHHHHHHHH---------- Confidence 11111111111 123444444433221 11111111111100000 Q NP_000290.2 495 RQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSD---AIRTYLNLMGKSKKDATLEACAGA 571 (747) Q Consensus 495 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G---~I~~LL~LL~ss~d~eVr~~AL~a 571 (747) .+.+- ... .+. ...+...+ .++.++.++. +.++.++..++.+ T Consensus 191 ------------------~~~~~----~~~---------~~~---~~~~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~ 235 (503) T 5XGC_A 191 ------------------LMVLL----LLG---------DES---MQKLFEGGKGSVFQRVLSWIP-SNNHQLQLAGALA 235 (503) T ss_dssp ------------------HHHHH----TTS---------HHH---HHHHHGGGTCHHHHHHHHHTT-SSCHHHHHHHHHH T ss_pred ------------------HHHHH----HhC---------Cch---HHHHHhcCcccHHHHHHHHcc-CCCHHHHHHHHHH Confidence 00000 000 000 01112222 6777888887 4677888899999 Q NP_000290.2 572 LQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ----SGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTS 646 (747) Q Consensus 572 L~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~----s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s 646 (747) |.+++..... ...+.+.++++.|+.++. +.+..++..++.+|.+++..... ..+...++++.+..++.+ T Consensus 236 L~~l~~~~~~------~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~ 309 (503) T 5XGC_A 236 IANFARNDAN------CIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKS 309 (503) T ss_dssp HHHHCSSHHH------HHHHHHTTHHHHHHHHHHTTTTTCCHHHHHHHHHHHHHHTCSHHHHHHHHHHTHHHHHHTTTTC T ss_pred HHHHHCChhH------HHHHHHCCHHHHHHHHHHhccccCCHHHHHHHHHHHHHhcCCHHHHHHHHHcCHHHHHHHHHcC Confidence 9999874321 333456688888988887 56788899999999999876433 333445678888888876 Q NP_000290.2 647 HTGNTSNSEDILSSACYTVRNLMASQPQLAKQYF-SSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 647 ~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lv-e~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .++.++..++++|.+++...+.....+. ..++++.++.++.+.....++..++.+|.+++... T Consensus 310 ------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~ 373 (503) T 5XGC_A 310 ------EMPPVQFKLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHS 373 (503) T ss_dssp ------CCHHHHHHHHHHHHHHTTTCHHHHHHHHTCHHHHHHHHHHHTCTTCHHHHHHHHHHHHHHHHHH T ss_pred ------CCHHHHHHHHHHHHHHHccCHHHHHHHccccchHHHHHHHHccCCccchHHHHHHHHHHHHHHc Confidence 3678899999999999875433333332 24567788888776523378888999998886544 No 72 >6BW9_A Importin subunit alpha-3, Protein W; Complex, Hendra virus, Importin, Karyopherin; 1.6A {Homo sapiens} Probab=97.70 E-value=1.6e-08 Score=102.40 Aligned_cols=367 Identities=16% Similarity=0.162 Sum_probs=222.4 Template_Neff=12.900 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTN 321 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~ 321 (747) ...++.+...+.+.++.++..++.++..+...... ....+...++++.+...+. ..++.++..++.++..++...... T Consensus 8 ~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~ 87 (459) T 6BW9_A 8 NTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQ 87 (459) T ss_dssp --CHHHHHHHHTCSSHHHHHHHHHHHHHHHHSSSSCCHHHHHHTTHHHHHHHHTTCTTCHHHHHHHHHHHHHHTTSCHHH T ss_pred ccchHHHHHhccccCHHHHHHHHHHHHHHhcCCCCCCHHHHHHCChHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHH Confidence 34556667777777788899999999888764321 1122333456777777776 456778888999998887654433 Q NP_000290.2 322 KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVD 399 (747) Q Consensus 322 ~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~ 399 (747) ...+...++++.+...+. +.++.++..++.++..++... .....+.. ++++.++.++... .+ T Consensus 88 ~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~~ 151 (459) T 6BW9_A 88 TQAVVQSNAVPLFLRLLH-SPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPS---------------IP 151 (459) T ss_dssp HHHHHHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHTCSTT---------------SC T ss_pred HHHHhhCCHHHHHHHHhc-CCChHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHhccCCC---------------CC Confidence 333334457777888776 556788889999999887652 22222333 5666666666421 12 Q NP_000290.2 400 PEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVL 479 (747) Q Consensus 400 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 479 (747) +++-..+..++..- ..............+++..+...+.. .+..-...+...| T Consensus 152 ~~~~~~a~~~l~~l---------------------~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l 204 (459) T 6BW9_A 152 ITFLRNVTWVMVNL---------------------CRHKDPPPPMETIQEILPALCVLIHH------TDVNILVDTVWAL 204 (459) T ss_dssp HHHHHHHHHHHHHH---------------------HCCCSSCCCHHHHHHHHHHHHHHTTC------CCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH---------------------hcCCCCCCCHHHHHHHHHHHHHHHhc------CCHHHHHHHHHHH Confidence 33333333332211 10000001111223344444433321 1112222223233 Q NP_000290.2 480 HNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKS 559 (747) Q Consensus 480 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss 559 (747) .++...- ......+.+.++++.++.++. + T Consensus 205 ~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~ 233 (459) T 6BW9_A 205 SYLTDAG--------------------------------------------------NEQIQMVIDSGIVPHLVPLLS-H 233 (459) T ss_dssp HHHHTSC--------------------------------------------------HHHHHHHHHTTCHHHHGGGGG-C T ss_pred HHHhhcC--------------------------------------------------hHHHHHHHhCChHHHHHHHcC-C Confidence 3322100 001112244567788888887 4 Q NP_000290.2 560 KKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVF 637 (747) Q Consensus 560 ~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI 637 (747) .++.++..++.+|.+++...+. ....+.+.++++.+..++.+.++.++..++.+|.+++... .. ......+++ T Consensus 234 ~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~ 308 (459) T 6BW9_A 234 QEVKVQTAALRAVGNIVTGTDE-----QTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLV 308 (459) T ss_dssp SSHHHHHHHHHHHHHHTTSCHH-----HHHHHHTTTGGGGCHHHHTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCH T ss_pred CCHHHHHHHHHHHHHHHcCCHH-----HHHHHhcccchhcHHHHhhCCCHHHHHHHHHHHHHHcCCCHHHHHHHHHCCHH Confidence 6778888999999999875332 2233344578888888888888889999999999998662 22 233445677 Q NP_000290.2 638 PEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQ-PQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 638 ~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s-~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) +.+..++.+ .++.++..++.+|.+++... ......+.+.++++.|..++.+. ++.++..++.+|.+++...+ T Consensus 309 ~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~a~~~l~~l~~~~~ 381 (459) T 6BW9_A 309 PMIIHLLDK------GDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVK-DAQVVQVVLDGLSNILKMAE 381 (459) T ss_dssp HHHHHHHHH------SCHHHHHHHHHHHHHHHHHCCHHHHHHHHHTTCHHHHHGGGGCS-CHHHHHHHHHHHHHHHHHCT T ss_pred HHHHHHHHh------CCHHHHHHHHHHHHHHHHhCCHHHHHHHHHCCcHHHHHHhcCCC-CHHHHHHHHHHHHHHHHHhH Confidence 888888776 36778899999999998532 22333444456788888888766 77889999999999876544 No 73 >5D5K_C Importin subunit alpha-1, Poly [ADP-ribose]; PARP-2 NLS, PARP-2, poly(ADP-ribose)polymerase-2, Importin; 1.9A {Mus musculus} Probab=97.66 E-value=2e-08 Score=101.26 Aligned_cols=364 Identities=17% Similarity=0.188 Sum_probs=216.7 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.++..+. ..++.++..++.++..++...+.....+...++++.+...+.+.+..++..++.++..++......... T Consensus 57 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 136 (466) T 5D5K_C 57 LIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDL 136 (466) T ss_dssp HHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHH T ss_pred cHHHHHHHhhCCCChHHHHHHHHHHHHHcCCChHHHHHHhccchHHHHHHHhcCCCCcHHHHHHHHHHHHhcCCHHHHHH Confidence 4555666665 345678888889998887654433334444567778888888777888999999999988654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAE-----IQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~e-----Vr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) +...++++.+...+. ..+.. ++..++.++..++.......... .++++.+..++.. T Consensus 137 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~---------------- 199 (466) T 5D5K_C 137 VIKHGAIDPLLALLA-VPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHH---------------- 199 (466) T ss_dssp HHHTTCHHHHHHTTC-SSCGGGSCHHHHHHHHHHHHHHSCCCSSCCCHHHHHHHHHHHHHHTTS---------------- T ss_pred HHHCCcHHHHHHHhh-CCCcccccHHHHHHHHHHHHHHHcCCCCCCChHHHHHHHHHHHHHHcC---------------- Confidence 334456677777775 33333 77788888888876433222221 2455666666542 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) .|+++...+..++..-.... + .....+ --.+++..|...+.. .+..-...+.. T Consensus 200 ~~~~~~~~a~~~l~~l~~~~------~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~ 252 (466) T 5D5K_C 200 NDPEVLADSCWAISYLTDGP------N--------------ERIEMV-VKKGVVPQLVKLLGA------TELPIVTPALR 252 (466) T ss_dssp SCHHHHHHHHHHHHHHTSSC------H--------------HHHHHH-HTTTCHHHHHHHHTC------SCHHHHHHHHH T ss_pred CCHHHHHHHHHHHHHHhcCC------c--------------hHHHHH-HHCChHHHHHHHhcC------CCchHHHHHHH Confidence 13444444444443211100 0 000000 012233333333221 11112222333 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) .|.++.... ......+.+.++++.++.++. T Consensus 253 ~l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~ 282 (466) T 5D5K_C 253 AIGNIVTGT--------------------------------------------------DEQTQKVIDAGALAVFPSLLT 282 (466) T ss_dssp HHHHHTTSC--------------------------------------------------HHHHHHHHHTTGGGGHHHHTT T ss_pred HHHHHhcCC--------------------------------------------------HHHHHHHHccChhHhHHHHhh Confidence 333332100 001112245567888888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGN 634 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~ 634 (747) +.++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. . .. ..+... T Consensus 283 -~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~ 356 (466) T 5D5K_C 283 -NPKTNIQKEATWTMSNITAGRQD-----QIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHC 356 (466) T ss_dssp -CSSHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTCHHHHHHHHHSSCHHHHHHHHHHHHHHHHHSCHHHHHHHHHT T ss_pred -CCCHHHHHHHHHHHHHHHcCCHH-----HHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHHHHhC Confidence 46778888999999999875332 233334557888899988888888999999999999875 2 22 233445 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS------QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~------s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ++++.+..++.+ .++.++..++.+|.+++.. .......+.+.++++.+..++.+. ++.++..++.++ T Consensus 357 ~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l 429 (466) T 5D5K_C 357 GIIEPLMNLLSA------KDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHE-NESVYKASLNLI 429 (466) T ss_dssp TCHHHHHHGGGC------SCHHHHHHHHHHHHHHHHHHHHTTCHHHHHHHHHHTTHHHHHHHGGGCS-SHHHHHHHHHHH T ss_pred CcHHHHHHHhhc------CCHHHHHHHHHHHHHHHHHHHHhCCCHHHHHHHHHcCHHHHHHHHHhCC-cHHHHHHHHHHH Confidence 577788888776 3678889999999999862 122333344456778888888766 788999999999 Q NP_000290.2 709 SDMWSSKE 716 (747) Q Consensus 709 snL~~~~~ 716 (747) .+++...+ T Consensus 430 ~~l~~~~~ 437 (466) T 5D5K_C 430 EKYFSVEE 437 (466) T ss_dssp HHHC---- T ss_pred HHhccCCc Confidence 99887543 No 74 >4UAF_B Importin alpha 1 import receptor; importin karyopherin complex NLS, PROTEIN; HET: PO4; 1.698A {Mus musculus} Probab=97.63 E-value=2.4e-08 Score=100.65 Aligned_cols=364 Identities=17% Similarity=0.187 Sum_probs=219.0 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.++..+. ..++.++..++.++..++...+.....+...++++.+...+.+.+..++..++.++..++......... T Consensus 57 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 136 (466) T 4UAF_B 57 LIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDL 136 (466) T ss_pred cHHHHHHHhhCCCChHHHHHHHHHHHHHhcCChHHHHHHHccChHHHHHHHhcCCCCCHHHHHHHHHHHHhcCCHHHHHH Confidence 4555666665 345678888888998887654433334444567778888888777888999999999988654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAE-----IQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~e-----Vr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) +...++++.+...+. ..... ++..++.++..++.......... .++++.+..++.. T Consensus 137 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~---------------- 199 (466) T 4UAF_B 137 VIKHGAIDPLLALLA-VPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHH---------------- 199 (466) T ss_pred HHHCCcHHHHHHHhh-CCCcccccHHHHHHHHHHHHHHHcCCCCCCChhHHHHHHHHHHHHHcC---------------- Confidence 334456677777775 33333 77788888888876433222221 2555666666542 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) .|+++...+..++..-... .+ .....+ --.+++..|...+.. .+..-...+.. T Consensus 200 ~~~~~~~~a~~~l~~l~~~------~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~ 252 (466) T 4UAF_B 200 NDPEVLADSCWAISYLTDG------PN--------------ERIEMV-VKKGVVPQLVKLLGA------TELPIVTPALR 252 (466) T ss_pred CCHHHHHHHHHHHHHHhcC------Cc--------------HHHHHH-HHCChHHHHHHHhcC------CChhHHHHHHH Confidence 1344544444444321100 00 000000 012233333333221 11112222233 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) .|.++.... ......+.+.++++.+..++. T Consensus 253 ~l~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~ 282 (466) T 4UAF_B 253 AIGNIVTGT--------------------------------------------------DEQTQKVIDAGALAVFPSLLT 282 (466) T ss_pred HHHHHhcCC--------------------------------------------------HHHHHHHhccCHHHHHHHHhc Confidence 333332100 001112245567888888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGN 634 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~ 634 (747) +.++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. . .. ..+... T Consensus 283 -~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~ 356 (466) T 4UAF_B 283 -NPKTNIQKEATWTMSNITAGRQD-----QIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHC 356 (466) T ss_pred -CCCHHHHHHHHHHHHHHhcCCHH-----HHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHHHHhC Confidence 46778888999999999875332 233334557888899998888888999999999999875 2 22 233445 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS------QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~------s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ++++.+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.++ T Consensus 357 ~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l 429 (466) T 4UAF_B 357 GIIEPLMNLLSA------KDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHE-NESVYKASLNLI 429 (466) T ss_pred CcHHHHHHHhhc------CCHHHHHHHHHHHHHHHHHHHHhCCChHHHHHHHHcCHHHHHHHHHhCC-CHHHHHHHHHHH Confidence 577788888776 3678889999999999862 122333344456778888888766 788999999999 Q NP_000290.2 709 SDMWSSKE 716 (747) Q Consensus 709 snL~~~~~ 716 (747) .+++...+ T Consensus 430 ~~l~~~~~ 437 (466) T 4UAF_B 430 EKYFSVEE 437 (466) T ss_pred HHHccCCc Confidence 99887543 No 75 >3L6X_A Catenin delta-1, E-cadherin; p120, catenin, cadherin, E-cadherin, armadillo; HET: SO4; 2.4A {Homo sapiens} Probab=97.63 E-value=2.7e-08 Score=108.38 Aligned_cols=364 Identities=16% Similarity=0.179 Sum_probs=198.9 Template_Neff=11.000 Q NP_000290.2 263 AIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTG 342 (747) Q Consensus 263 ~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~ 342 (747) ..++.+|..+....+. ...+..+.++.++.++...++.++..++.+|..++.........+...++++.|+.++. .. T Consensus 26 ~~~l~~L~~l~~~~~~--~~~~~~~~l~~li~~L~~~~~~v~~~a~~~L~~L~~~~~~~~~~~~~~g~i~~Lv~lL~-~~ 102 (584) T 3L6X_A 26 RGSLASLDSLRKGGPP--PPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLD-HP 102 (584) T ss_dssp --------------CC--CCCCCCCCHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHGGG-CS T ss_pred cCchHHHHHHhcCCCC--CCcccCCcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCChHHHHHHHHCCcHHHHHHHhh-CC Confidence 3445555555443221 11233467778888887777888999999999988544444444455567888888887 56 Q NP_000290.2 343 NAEIQKQLTGLLWNLSS--TDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMREL 419 (747) Q Consensus 343 d~eVr~~AL~aLsnLas--~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 419 (747) ++.++..++.+|.+++. .......+.. ++++.|+.+|... .|+++-..+.++|.. T Consensus 103 ~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~i~~L~~ll~~~---------------~~~~v~~~a~~~L~~------- 160 (584) T 3L6X_A 103 KKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKA---------------RDMDLTEVITGTLWN------- 160 (584) T ss_dssp SHHHHHHHHHHHHHHTSSSCHHHHHHHHHTTHHHHHHHHHHHC---------------CSHHHHHHHHHHHHH------- T ss_pred CHHHHHHHHHHHHHHhcCCCHHHHHHHHcCChHHHHHHHHHHc---------------CCHHHHHHHHHHHHH------- Confidence 67899999999999987 3344444444 7888888888731 134444455555432 Q NP_000290.2 420 LALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEY 499 (747) Q Consensus 420 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 499 (747) |++.+..+..+... .+..|...+........ ...+ +.. .+. T Consensus 161 --------------L~~~~~~~~~l~~~--~l~~L~~~l~~~~~~~~---~~~~---------------~~~----~~~- 201 (584) T 3L6X_A 161 --------------LSSHDSIKMEIVDH--ALHALTDEVIIPHSGWE---REPN---------------EDC----KPR- 201 (584) T ss_dssp --------------HTTSGGGHHHHHHH--THHHCCCCCCHHHHCCC--------------------------------- T ss_pred --------------HhcCHHHHHHHHHH--HHHHHHHhccccCCCCC---CCCC---------------cCC----CCc- Confidence 11111122222211 22233322221110000 0000 000 000 Q NP_000290.2 500 NARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYH-SDAIRTYLNLMGK-----SKKDATLEACAGALQ 573 (747) Q Consensus 500 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve-~G~I~~LL~LL~s-----s~d~eVr~~AL~aL~ 573 (747) ...+........+|+.|-+. .+......+.+ .++++.|+.++.. ..+..++..++.+|. T Consensus 202 ~~~~~~v~~~a~~~L~~l~~---------------~~~~~~~~l~~~~g~v~~L~~~l~~~~~~~~~~~~~~~~a~~~L~ 266 (584) T 3L6X_A 202 HIEWESVLTNTAGCLRNVSS---------------ERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLR 266 (584) T ss_dssp CCCCHHHHHHHHHHHHHHTS---------------SCHHHHHHHHHSTTHHHHHHHHHHHHHHTTCCSCHHHHHHHHHHH T ss_pred ccChHHHHHHHHHHHHHHhc---------------CCHHHHHHHHhCCCHHHHHHHHHHHHhcCCCCChHHHHHHHHHHH Confidence 00000111112222222211 00011111223 4667888887762 125667778888888 Q NP_000290.2 574 NLTASKGLMS--------------------SGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRH-----PL 627 (747) Q Consensus 574 nLs~~s~~~s--------------------~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~-----~e 627 (747) +++....... .......+.+.++++.|+.++... ++.++..++.+|.+|+.. .. T Consensus 267 ~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~ll~~~~~~~~~~~a~~~L~~L~~~~~~~~~~ 346 (584) T 3L6X_A 267 NLSYQVHREIPQAERYQEAAPNVANNTGTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRY 346 (584) T ss_dssp HHHTTHHHHSTTCCC--------------CCCCGGGGGGSHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHSSCSHHHHH T ss_pred HHHhhhhccChhHHHHHHhcCcCCCCCCCCChhhhhHhhChhHHHHHHHHHHcCCCHHHHHHHHHHHHHHhCCCccCCHH Confidence 8876421000 000122334568888899988875 788999999999999874 22 Q NP_000290.2 628 L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA-------SPK 699 (747) Q Consensus 628 ~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~-------d~e 699 (747) . ..+...++++.|+.++.. .+..++..++++|.+|+.. +.....+. .++++.|+.++.... +.. T Consensus 347 ~~~~~~~~~~l~~L~~ll~~------~~~~v~~~a~~~L~~L~~~-~~~~~~l~-~~~l~~L~~~L~~~~~~~~~~~~~~ 418 (584) T 3L6X_A 347 IRSALRQEKALSAIADLLTN------EHERVVKAASGALRNLAVD-ARNKELIG-KHAIPNLVKNLPGGQQNSSWNFSED 418 (584) T ss_dssp HHHHHTSHHHHHHHHHGGGC------SCHHHHHHHHHHHHHHHTT-CSCHHHHH-HHHHHHHHHTSSSSSCSGGGTCCHH T ss_pred HHHHHHHcChHHHHHHHhcC------CCHHHHHHHHHHHHHHhcC-hHHHHHHH-cchHHHHHHcCCCCCCCCCcCCCHH Confidence 2 233456788888888876 3678899999999999875 44444443 467888888776431 234 Q NP_000290.2 700 AAEAARLLLSDMWS 713 (747) Q Consensus 700 Vr~aAL~aLsnL~~ 713 (747) ++..++.+|.+++. T Consensus 419 ~~~~~l~~L~~l~~ 432 (584) T 3L6X_A 419 TVISILNTINEVIA 432 (584) T ss_dssp HHHHHHHHHHHHHT T ss_pred HHHHHHHHHHHHHh Confidence 46778888888773 No 76 >4U5L_A deltaIBB-importin-alpha1; TPX2, inhibitor, TRANSPORT PROTEIN; HET: 3D6; 2.53A {Mus musculus} Probab=97.60 E-value=2.9e-08 Score=98.47 Aligned_cols=367 Identities=14% Similarity=0.181 Sum_probs=226.7 Template_Neff=13.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) ..++.+...+.+.++.++..++..+..+...... ....+...++++.+...+. ..++.++..++.++..++....... T Consensus 5 ~~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~ 84 (426) T 4U5L_A 5 WSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQT 84 (426) T ss_dssp CCHHHHHHHHTSSCHHHHHHHHHHHHHHHHCSSCCCHHHHHHTTCHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHHH T ss_pred ccHHHHHhhccCCCHHHHHHHHHHHHHHHhcCCCccHHHHHHcCcHHHHHHHhccCCChHHHHHHHHHHHHHhCCCHHHH Confidence 4556667777777888889999999888764322 1222333456777777776 4456788889999988876544333 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDP 400 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~ 400 (747) ..+...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++..... +..++ T Consensus 85 ~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~-----------~~~~~ 152 (426) T 4U5L_A 85 KAVVDGGAIPAFISLLA-SPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDL-----------STLAC 152 (426) T ss_dssp HHHHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHHTCHHHHHHHHHTTCHHHHHHTTCSSCG-----------GGSCH T ss_pred HHHHhcCcHHHHHHHhc-CCChHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhhCCCC-----------chhhH Confidence 33344467777888776 5677888999999999887543 2223333 677777777764211 11122 Q NP_000290.2 401 EVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLH 480 (747) Q Consensus 401 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 480 (747) ++...+..++..- ..............+++..+...++. .+..-...+...|. T Consensus 153 ~~~~~~~~~l~~l---------------------~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~ 205 (426) T 4U5L_A 153 GYLRNLTWTLSNL---------------------CRNKNPAPPLDAVEQILPTLVRLLHH------NDPEVLADSCWAIS 205 (426) T ss_dssp HHHHHHHHHHHHH---------------------TCCCSSCCCHHHHHHHHHHHHHHTTS------SCHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHH---------------------HcCCCCCCCccHHHHHHHHHHHHHhC------CCHHHHHHHHHHHH Confidence 2333333222211 11111111111113344444333321 11122222222232 Q NP_000290.2 481 NLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSK 560 (747) Q Consensus 481 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~ 560 (747) ++...-. .....+.+.++++.++.++. +. T Consensus 206 ~l~~~~~--------------------------------------------------~~~~~~~~~~~~~~l~~~l~-~~ 234 (426) T 4U5L_A 206 YLTDGPN--------------------------------------------------ERIEMVVKKGVVPQLVKLLG-AT 234 (426) T ss_dssp HHTSSCH--------------------------------------------------HHHHHHHTTTCHHHHHHHHT-CS T ss_pred HHhhCCc--------------------------------------------------HHHHHHhhcChHHHHHHHhc-CC Confidence 2221100 00111234567888888887 46 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFP 638 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~ 638 (747) ++.++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++.. +.. ..+...++++ T Consensus 235 ~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~ 309 (426) T 4U5L_A 235 ELPIVTPALRAIGNIVTGTDE-----QTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVP 309 (426) T ss_dssp CHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTGGGGHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHH T ss_pred CccHHHHHHHHHHHHhcCCHH-----HHHHHhccchHHHHHHHhcCCChHHHHHHHHHHHHHhcCCHHHHHHHHHCCHHH Confidence 778888999999999875332 233334567888999999888889999999999999875 222 2334456778 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS-QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~-s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) .+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.+|.+++. T Consensus 310 ~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~ 378 (426) T 4U5L_A 310 FLVGVLSK------ADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAK-DTKIIQVILDAISNIFQ 378 (426) T ss_dssp HHHHHHHS------SCHHHHHHHHHHHHHHHHHCCHHHHHHHHHTTCHHHHHHGGGSC-CHHHHHHHHHHHHHHHH T ss_pred HHHHHhcC------CCHHHHHHHHHHHHHHHcCCCHHHHHHHHhCCcHHHHHHHhcCC-CHHHHHHHHHHHHHHHH Confidence 88888876 3678889999999999874 233334455556788888888876 78899999999999976 No 77 >4MZ6_E Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Importin; ARM repeat, protein transport, Importin; 1.88A {Mus musculus} Probab=97.58 E-value=3.4e-08 Score=101.56 Aligned_cols=364 Identities=17% Similarity=0.184 Sum_probs=217.7 Template_Neff=12.800 Q NP_000290.2 246 TIPKAVQYLSSQ-DEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ss-d~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+. ++.++..++.++..++...+.....+...++++.+...+.+.++.++..++.++..++......... T Consensus 101 ~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 180 (509) T 4MZ6_E 101 LIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDL 180 (509) T ss_dssp HHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHH T ss_pred cHHHHHHHhcCCCChHHHHHHHHHHHHHhCCCHHHHHHHHhcChHHHHHHHhcCCChhHHHHHHHHHHHHhCCCHHHHHH Confidence 455566666543 3678888889988887654443334444567788888888777888999999999888654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAE-----IQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~e-----Vr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) +...++++.+...+. ..... ++..++.++..++.......... .++++.+..++.. T Consensus 181 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~---------------- 243 (509) T 4MZ6_E 181 VIKHGAIDPLLALLA-VPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHH---------------- 243 (509) T ss_dssp HHHTTCHHHHHHHTC-SSCGGGSCHHHHHHHHHHHHHHHCCCSSCCCHHHHHHHHHHHHHHTTC---------------- T ss_pred HHHCCcHHHHHHHHh-CCChhhhhHHHHHHHHHHHHHHhcCCCCCCCHHHHHHHHHHHHHHHhC---------------- Confidence 334456677777775 33333 77788888888876432221111 2556666666542 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) .++++...+..++..-.... + .....+ --.+++..|...++. .+..-...+.. T Consensus 244 ~~~~v~~~a~~~l~~l~~~~------~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~ 296 (509) T 4MZ6_E 244 NDPEVLADSCWAISYLTDGP------N--------------ERIEMV-VKKGVVPQLVKLLGA------TELPIVTPALR 296 (509) T ss_dssp SCHHHHHHHHHHHHHHTSSS------H--------------HHHHHH-HTTTCHHHHHHHHTC------SCHHHHHHHHH T ss_pred CCHHHHHHHHHHHHHHhcCC------h--------------HHHHHH-hhCChHHHHHHHhcC------CCcchHHHHHH Confidence 13444444444443211100 0 000000 012233333333321 11112222333 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) +|.++.... ......+.+.++++.|..++. T Consensus 297 ~L~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~ 326 (509) T 4MZ6_E 297 AIGNIVTGT--------------------------------------------------DEQTQKVIDAGALAVFPSLLT 326 (509) T ss_dssp HHHHHTTSC--------------------------------------------------HHHHHHHHHTTGGGGHHHHTT T ss_pred HHHHHhcCC--------------------------------------------------HHHHHHHHhCChHHHHHHHhh Confidence 333322100 001112245567788888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH--PLL-HRVMGN 634 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~--~e~-~~ll~~ 634 (747) +.++.++..++.+|.+++...+. ....+...++++.|+.++.+.++.++..++.+|.+++.. ... ..+... T Consensus 327 -~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~ 400 (509) T 4MZ6_E 327 -NPKTNIQKEATWTMSNITAGRQD-----QIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHC 400 (509) T ss_dssp -CSSHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHHHSSCHHHHHHHHHHHHHHHHHSCHHHHHHHHHT T ss_pred -CCCHHHHHHHHHHHHHHhcCCHH-----HHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHHHHhC Confidence 46778888999999998875332 233334557888888888888888999999999999875 222 233445 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS------QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~------s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ++++.+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.+| T Consensus 401 ~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l 473 (509) T 4MZ6_E 401 GIIEPLMNLLSA------KDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHE-NESVYKASLNLI 473 (509) T ss_dssp TCHHHHHHGGGC------SCHHHHHHHHHHHHHHHHHHHHHTCHHHHHHHHHHTTHHHHHHHHTTCS-SHHHHHHHHHHH T ss_pred CCHHHHHHHHhC------CCHHHHHHHHHHHHHHHHHHHHcCCCchHHHHHHHcCHHHHHHHHHhCC-CHHHHHHHHHHH Confidence 577888888776 3678888999999998862 123333344456788888888776 788999999999 Q NP_000290.2 709 SDMWSSKE 716 (747) Q Consensus 709 snL~~~~~ 716 (747) ..+....+ T Consensus 474 ~~l~~~~~ 481 (509) T 4MZ6_E 474 EKYFSVEE 481 (509) T ss_dssp HHHCC--- T ss_pred HHHCCCCc Confidence 99886543 No 78 >5UMZ_B Importin subunit alpha-1, TNRC6A; mRNA decay, miRNA ARM repeat; HET: GOL; 1.9A {Mus musculus} Probab=97.58 E-value=3.4e-08 Score=101.56 Aligned_cols=364 Identities=17% Similarity=0.184 Sum_probs=219.0 Template_Neff=12.800 Q NP_000290.2 246 TIPKAVQYLSSQ-DEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ss-d~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+. ++.++..++.++..++...+.....+...++++.+...+.+.++.++..++.++..++......... T Consensus 101 ~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 180 (509) T 5UMZ_B 101 LIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDL 180 (509) T ss_dssp CHHHHHHHHTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHHHTCHHHHHH T ss_pred cHHHHHHHhcCCCChHHHHHHHHHHHHHhCCCHHHHHHHHhcChHHHHHHHhcCCChhHHHHHHHHHHHHhCCCHHHHHH Confidence 455566666543 3678888889988887654443334444567788888888777888999999999888654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAE-----IQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~e-----Vr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) +...++++.+...+. ..... ++..++.++..++.......... .++++.+..++.. T Consensus 181 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~---------------- 243 (509) T 5UMZ_B 181 VIKHGAIDPLLALLA-VPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHH---------------- 243 (509) T ss_dssp HHHTTCHHHHHHHTC-SSCGGGSCHHHHHHHHHHHHHHHCCCSSCCCHHHHHHHHHHHHHHTTS---------------- T ss_pred HHHCCcHHHHHHHHh-CCChhhhhHHHHHHHHHHHHHHhcCCCCCCCHHHHHHHHHHHHHHHhC---------------- Confidence 334456677777775 33333 77788888888876432221111 2556666666542 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) .++++...+..++..-.... + .....+ --.+++..|...++. .+..-...+.. T Consensus 244 ~~~~v~~~a~~~l~~l~~~~------~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~ 296 (509) T 5UMZ_B 244 NDPEVLADSCWAISYLTDGP------N--------------ERIEMV-VKKGVVPQLVKLLGA------TELPIVTPALR 296 (509) T ss_dssp SCHHHHHHHHHHHHHHTSSC------H--------------HHHHHH-HTTTCHHHHHHHHTC------SCHHHHHHHHH T ss_pred CCHHHHHHHHHHHHHHhcCC------h--------------HHHHHH-hhCChHHHHHHHhcC------CCcchHHHHHH Confidence 13444444444443211100 0 000000 012233333333321 11112222333 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) +|.++.... ......+.+.++++.|..++. T Consensus 297 ~L~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~ 326 (509) T 5UMZ_B 297 AIGNIVTGT--------------------------------------------------DEQTQKVIDAGALAVFPSLLT 326 (509) T ss_dssp HHHHHTTSC--------------------------------------------------HHHHHHHHHTTGGGGHHHHTT T ss_pred HHHHHhcCC--------------------------------------------------HHHHHHHHhCChHHHHHHHhh Confidence 333322100 001112245567788888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH--PLL-HRVMGN 634 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~--~e~-~~ll~~ 634 (747) +.++.++..++.+|.+++...+. ....+...++++.|+.++.+.++.++..++.+|.+++.. ... ..+... T Consensus 327 -~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~ 400 (509) T 5UMZ_B 327 -NPKTNIQKEATWTMSNITAGRQD-----QIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHC 400 (509) T ss_dssp -CSSHHHHHHHHHHHHHHHTSCHH-----HHHHHHHTTHHHHHHHHHHSSCHHHHHHHHHHHHHHHHHSCHHHHHHHHHT T ss_pred -CCCHHHHHHHHHHHHHHhcCCHH-----HHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHHHHhC Confidence 46778888999999998875332 233334557888888888888888999999999999875 222 233445 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS------QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~------s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ++++.+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.+| T Consensus 401 ~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l 473 (509) T 5UMZ_B 401 GIIEPLMNLLSA------KDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHE-NESVYKASLNLI 473 (509) T ss_dssp TCHHHHHHGGGC------SCHHHHHHHHHHHHHHHHHHHHHTCHHHHHHHHHHTTHHHHHHHHHTCS-CHHHHHHHHHHH T ss_pred CCHHHHHHHHhC------CCHHHHHHHHHHHHHHHHHHHHcCCCchHHHHHHHcCHHHHHHHHHhCC-CHHHHHHHHHHH Confidence 577888888776 3678888999999998862 123333344456788888888776 788999999999 Q NP_000290.2 709 SDMWSSKE 716 (747) Q Consensus 709 snL~~~~~ 716 (747) ..+....+ T Consensus 474 ~~l~~~~~ 481 (509) T 5UMZ_B 474 EKYFSVEE 481 (509) T ss_dssp HHHCCCCC T ss_pred HHHCCCCc Confidence 99886543 No 79 >5ZHX_D Rap1 GTPase-GDP dissociation stimulator 1; armadillo GEF chaperone, ONCOPROTEIN; HET: FAR; 3.5A {Homo sapiens} Probab=97.57 E-value=3.6e-08 Score=99.74 Aligned_cols=332 Identities=20% Similarity=0.193 Sum_probs=197.3 Template_Neff=13.200 Q NP_000290.2 282 QVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTG--NAEIQKQLTGLLWNLSS 359 (747) Q Consensus 282 ~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~--d~eVr~~AL~aLsnLas 359 (747) .+...++++.+...+.+.++.++..++.++..++...+.....+...++++.+...+. .. ++.++..++.++..++. T Consensus 13 ~l~~~~~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~i~~l~~~l~-~~~~~~~v~~~a~~~l~~l~~ 91 (487) T 5ZHX_D 13 PCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLG-IHCQNAALTEMCLVAFGNLAE 91 (487) T ss_dssp ---CHHHHHHHHHHTTCSCHHHHHHHHHHHHTTSTTCHHHHHHHHHTTCHHHHHHHHH-HTSSCSHHHHHHHHHHHHHTT T ss_pred HHhhcCcHHHHHHHHcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHHc-ccCCCHHHHHHHHHHHHHHHc Confidence 3444567778888888778889999999999988654443334444567788888886 43 67888899999999887 Q NP_000290.2 360 TDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSAD 438 (747) Q Consensus 360 ~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 438 (747) .......+.. ++++.|+.++.... ++++-..+..+|..- ...+ T Consensus 92 ~~~~~~~~~~~~~~~~l~~~l~~~~---------------~~~~~~~a~~~l~~l---------------------~~~~ 135 (487) T 5ZHX_D 92 LESSKEQFASTNIAEELVKLFKKQI---------------EHDKREMIFEVLAPL---------------------AEND 135 (487) T ss_dssp SSHHHHHHHHTTHHHHHHHHHHHCC---------------SHHHHHHHHHHHHHH---------------------HTSH T ss_pred chhHHHHHhhCCHHHHHHHHHHhcc---------------ChHHHHHHHHHHHHH---------------------hcCH Confidence 6443333333 67777777776431 333333333333211 1111 Q NP_000290.2 439 AGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKS 518 (747) Q Consensus 439 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 518 (747) ..+..+. ..|.++.|+..+... ++.........+..... .+.+.. T Consensus 136 ~~~~~~~-~~~~~~~l~~~l~~~------~~~~~~~~~~~l~~~~~----------------------------~~~~~~ 180 (487) T 5ZHX_D 136 AIKLQLV-EAGLVECLLEIVQQK------VDSDKEDDITELKTGSD----------------------------LMVLLL 180 (487) T ss_dssp HHHHHHH-HHTHHHHHHHHHHHT------SSCCCHHHHHHHHHHHH----------------------------HHHHHT T ss_pred HHHHHHH-HCCHHHHHHHHHHhc------CCCCCHHHHHHHHHHHH----------------------------HHHHHH Confidence 1111111 123444444433321 11111111111110000 000000 Q NP_000290.2 519 DKMMNNNYDCPLPEEETNPKGSGWLYHSD---AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEK 595 (747) Q Consensus 519 ~~~~~~~~~~~~~~~~~ni~~~~~lve~G---~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~g 595 (747) .+ .+. ...+...+ .++.++.++. +.++.++..++.+|.+++.... ....+.+.+ T Consensus 181 ----~~---------~~~---~~~~~~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~------~~~~~~~~~ 237 (487) T 5ZHX_D 181 ----LG---------DES---MQKLFEGGKGSVFQRVLSWIP-SNNHQLQLAGALAIANFARNDA------NCIHMVDNG 237 (487) T ss_dssp ----TS---------HHH---HHHHSSSSSSSHHHHHHTTTT-SSCHHHHHHHHHHHHHHCCSHH------HHHHHHTTT T ss_pred ----hc---------cHH---HHHHhhCCCchHHHHHHHHcc-CCCHHHHHHHHHHHHHHHcCch------HHHHHHhcC Confidence 00 000 01112222 6777888887 4677888899999999987432 133345567 Q NP_000290.2 596 GLPQIARLLQ----SGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 596 iI~~Ll~LL~----s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) +++.++.++. +.+..++..++.+|.+++..... ..+...++++.+..++.+ .++.++..++++|.+++. T Consensus 238 ~~~~l~~~l~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~ 311 (487) T 5ZHX_D 238 IVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKS------EMPPVQFKLLGTLRMLID 311 (487) T ss_dssp HHHHHHHHHHHTSSSSCHHHHHHHHHHHHHHTCSHHHHHHHHHHTHHHHHHTTSSC------CCHHHHHHHHHHHHHHTS T ss_pred HHHHHHHHHHhcccCCCHHHHHHHHHHHHHhcCChhhHHHHHHcChHHHHHHHHhC------CCHHHHHHHHHHHHHHHh Confidence 8888888887 56788899999999999876433 233445677888888876 367889999999999987 Q NP_000290.2 671 SQPQLAKQYF-SSSMLNNIINLCRSSASP-KAAEAARLLLSDMWSSK 715 (747) Q Consensus 671 ~s~e~~~~Lv-e~giL~~Ll~LL~s~~d~-eVr~aAL~aLsnL~~~~ 715 (747) ..+.....+. ..++++.++.++.+. +. .++..++.+|.+++... T Consensus 312 ~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~a~~~l~~l~~~~ 357 (487) T 5ZHX_D 312 AQAEAAEQLGKNVKLVERLVEWCEAK-DHAGVMGESNRLLSALIRHS 357 (487) T ss_dssp SCHHHHHHHHHCHHHHHHHHHHHTCC-SCCHHHHHHHHHHHHHHHHH T ss_pred hcHHHHHHhccccCHHHHHHHHHHhc-CchhhHHHHHHHHHHHHHHh Confidence 5433333333 245678888888765 44 78888999999986544 No 80 >3NOW_A SD10334p; Armadillo Repeat, Hsp90, Myosin, Tetra-tricopeptide; 2.992A {Drosophila melanogaster} Probab=97.57 E-value=3.6e-08 Score=107.84 Aligned_cols=135 Identities=17% Similarity=0.118 Sum_probs=82.7 Template_Neff=12.800 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.++.++..++.++..+... .... .....++++.+...+.+.+..++..++.++..+......... T Consensus 289 ~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~-~~~~-~~~~~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~ 366 (810) T 3NOW_A 289 EGILQMILAMATTDDELQQRVACECLIAASSK-KDKA-KALCEQGVDILKRLYHSKNDGIRVRALVGLCKLGSYGGQDAA 366 (810) T ss_dssp TTHHHHHHHHHHSSCHHHHHHHHHHHHHHTTS-HHHH-HTTHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHHTTTTTTTS T ss_pred cChHHHHHHHccCCCHHHHHHHHHHHHHHhCC-HHHH-HHHHhhhHHHHHHHhcCCCHHHHHHHHHHHHHHHccCCcccc Confidence 44556666677777788899999999888764 2111 122235677777777777788888999999888764332111 Q NP_000290.2 324 ET-RRQNGIREAVSLLRR-----TGNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVI 380 (747) Q Consensus 324 ~l-l~~~IL~~Ll~lL~s-----s~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~ 380 (747) .. ...+.++.+...+.. +.++.++..++.++..++........+.. ++++.+..++. T Consensus 367 ~~~~~~~~~~~l~~~l~~~l~~~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 431 (810) T 3NOW_A 367 IRPFGDGAALKLAEACRRFLIKPGKDKDIRRWAADGLAYLTLDAECKEKLIEDKASIHALMDLAR 431 (810) T ss_dssp CCSSTTTHHHHHHHHHHHHHHCSSCCSSHHHHHHHHHHHHTTSHHHHHHHHHCHHHHHHHHHHHH T ss_pred ccccCCCHHHHHHHHHHHHHhCCCCCHHHHHHHHHHHHHHcCCHHHHHHHHhChHHHHHHHHHHc Confidence 11 122344445544431 24567888889999888765433333322 46666666665 No 81 >4EV8_A Catenin beta-1; mouse catenin, CELL ADHESION; HET: URE; 1.9A {Mus musculus} Probab=97.55 E-value=4.1e-08 Score=100.94 Aligned_cols=137 Identities=25% Similarity=0.276 Sum_probs=86.1 Template_Neff=13.100 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLR--SPNQNVQQAAAGALRNLVFRSTTN- 321 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~--s~d~eVr~~AL~aLs~La~~~~~~- 321 (747) .+++.+...+.+.+..++..++.++..+..........+...+.++.+...+. ..++.++..++.++..++...... T Consensus 267 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~~~~ 346 (538) T 4EV8_A 267 GLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAE 346 (538) T ss_pred CcHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHHhcCCCCHHHHHHHHHHHHHHHcCCCChH Confidence 34555666666666778888888888886544433333344556667776665 445677888888888887644321 Q NP_000290.2 322 --KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVII 381 (747) Q Consensus 322 --~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~ 381 (747) .......++++.+...+....++.++..++.++..++........+.. ++++.|..++.. T Consensus 347 ~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~ 409 (538) T 4EV8_A 347 MAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVR 409 (538) T ss_pred HHHHHHHHCCHHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCHHHHHHHHHCChHHHHHHHHcC Confidence 112222356677777775223567888888999888875444433444 677777776653 No 82 >5Z8H_A Adenomatous polyposis coli protein, Peptide; APC, inhibitor, PROTEIN BINDING-INHIBITOR complex; HET: PHQ, GOL; 1.79A {Homo sapiens} Probab=97.54 E-value=4.4e-08 Score=95.72 Aligned_cols=161 Identities=21% Similarity=0.247 Sum_probs=120.5 Template_Neff=12.500 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLK-EKGLPQIARLLQSGN----SDVVRSGASL 618 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie-~giI~~Ll~LL~s~d----~eVr~~AL~a 618 (747) .+.++++.|+.++....++.++..++++|.+++...+. ....+.. .++++.++.++...+ ..++..++++ T Consensus 162 ~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~ 236 (339) T 5Z8H_A 162 REVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTE-----NKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGI 236 (339) T ss_pred HHCCcHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHH-----HHHHHHHhcChHHHHHHHhcCCCCCCCHHHHHHHHHH Confidence 45678888888887325677888899999999874332 2334455 688888988887543 6788889999 Q NP_000290.2 619 LSNMSR----HPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR 693 (747) Q Consensus 619 LsnLa~----~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~ 693 (747) |.+++. .+.. ..+...++++.++.++.. .++.++..++++|.+++...+.....+.+.++++.|..++. T Consensus 237 l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 310 (339) T 5Z8H_A 237 LRNVSSLIATNEDHRQILRENNCLQTLLQHLKS------HSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIH 310 (339) T ss_pred HHHHHHhhccCHHHHHHHHHCCHHHHHHHHHhC------CCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHhh Confidence 999873 2222 233445678888888866 36778999999999999844666666667788999999988 Q NP_000290.2 694 SSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 694 s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) +. ++.++..++.+|.+++...+ T Consensus 311 ~~-~~~v~~~a~~~l~~l~~~~~ 332 (339) T 5Z8H_A 311 SK-HKMIAMGSAAALRNLMANRP 332 (339) T ss_pred CC-CHHHHHHHHHHHHHHHcCCc Confidence 76 78899999999999997654 No 83 >3SL9_B Catenin beta-1, B-cell CLL/lymphoma 9; Armadillo repeat, components of the; HET: GOL, EDO, PEG, IMD; 2.2A {Homo sapiens} Probab=97.53 E-value=4.8e-08 Score=84.82 Aligned_cols=134 Identities=16% Similarity=0.203 Sum_probs=89.6 Template_Neff=12.600 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQL-GGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~-~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .+++.+...+.+.++.++..++.++.++..... ....+... ++++.+..++.. .+..++..++.++.+++.. .... T Consensus 13 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~-~~~~ 90 (167) T 3SL9_B 13 RAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEA-SRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHH-REGL 90 (167) T ss_pred CcHHHHHHHhCCCCHHHHHHHHHHHHHHccCHH-HHHHHHhCCchHHHHHHHHhcCCCHHHHHHHHHHHHHHcCC-HhHH Confidence 345566666666677788889999998876543 22223332 377778887776 6677888899999888843 3333 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVII 381 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~~ 381 (747) ..+...+.++.+..++. ..++.++..++.++.+++........++. ++++.|+.++.. T Consensus 91 ~~~~~~~~i~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~ 150 (167) T 3SL9_B 91 LAIFKSGGIPALVKMLG-SPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNK 150 (167) T ss_pred HHHHHCCcHHHHHHHhC-CCCHHHHHHHHHHHHHHHcCCHhHHHHHHHcCHHHHHHHHhcC Confidence 33444567778888886 55677888899999998875443333332 677777777654 No 84 >4E4V_A Importin subunit alpha-2; armadillo repeat, karyopherin, importin, nuclear; HET: GOL, DTT; 2.5283A {Homo sapiens} Probab=97.52 E-value=5e-08 Score=99.91 Aligned_cols=156 Identities=17% Similarity=0.216 Sum_probs=117.7 Template_Neff=12.700 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++++.++.++. +.++.++..++.+|.+++..... ....+...++++.+..++.+.++.++..++.+|.+++.. T Consensus 206 ~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~ 279 (485) T 4E4V_A 206 EQILPTLVRLLH-HDDPEVLADTCWAISYLTDGPNE-----RIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTG 279 (485) T ss_dssp HHHHHHHHHHTT-SCCHHHHHHHHHHHHHHTSSCHH-----HHHHHHTTTCHHHHHHHHTCSCHHHHHHHHHHHHHHTTS T ss_pred hcHHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCChH-----HhhHHhhCChHHHHHHHhcCCChHHHHHHHHHHHHHhcC Confidence 356777888887 46778888999999998875332 223334567888899999888888999999999999876 Q NP_000290.2 626 P-LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 626 ~-e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) . .. ......++++.+..++.+ .++.++..++.+|.+++...+.....+...++++.|+.++.+. ++.++.. T Consensus 280 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~ 352 (485) T 4E4V_A 280 TDEQTQVVIDAGALAVFPSLLTN------PKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKA-DFKTQKE 352 (485) T ss_dssp CHHHHHHHHHTTGGGGHHHHHTC------SSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHHHHS-CHHHHHH T ss_pred CHHHHHHHHhCChHHHHHHHhcC------CCHHHHHHHHHHHHHHcCCCHHHHHHHHHCCHHHHHHHHHhcC-CHHHHHH Confidence 2 22 233445678888888876 3678899999999999876555555566667788888888766 7788889 Q NP_000290.2 704 ARLLLSDMWSS 714 (747) Q Consensus 704 AL~aLsnL~~~ 714 (747) ++.+|.+++.. T Consensus 353 a~~~l~~l~~~ 363 (485) T 4E4V_A 353 AVWAVTNYTSG 363 (485) T ss_dssp HHHHHHHHHHH T ss_pred HHHHHHHHHhc Confidence 99999888865 No 85 >1WA5_B GTP-BINDING NUCLEAR PROTEIN RAN, IMPORTIN; NUCLEAR TRANSPORT-COMPLEX, NUCLEAR TRANSPORT, EXPORTIN; HET: GTP; 2.0A {CANIS FAMILIARIS} SCOP: a.118.1.1 Probab=97.52 E-value=5.1e-08 Score=102.06 Aligned_cols=368 Identities=16% Similarity=0.204 Sum_probs=223.8 Template_Neff=12.300 Q NP_000290.2 242 CSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDES-AKQQVYQLGGICKLVDLLRSPN-QNVQQAAAGALRNLVFRST 319 (747) Q Consensus 242 ~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~-~~~~li~~~IL~~Ll~lL~s~d-~eVr~~AL~aLs~La~~~~ 319 (747) .....++.++..+.+.++.++..++..+..++..... ....+...++++.+...+...+ +.++..++.+|..++.... T Consensus 84 ~~~~~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~L~~~l~~~~~~~v~~~a~~~L~~l~~~~~ 163 (530) T 1WA5_B 84 QLQQELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTS 163 (530) T ss_dssp ---CCHHHHHHHHSCSSHHHHHHHHHHHHHHTCCSSSCSHHHHHHTTCHHHHHHTTSTTSCHHHHHHHHHHHHHHTTSCH T ss_pred HHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHcCCCCCCHHHHHHcChHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCH Confidence 3445566666777777777888888888887653221 1223333457777777776543 6677888899988876443 Q NP_000290.2 320 TNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 320 ~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) .....+...++++.+...+. ..++.++..++.++..++... .....+.. ++++.|+.++... T Consensus 164 ~~~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~--------------- 227 (530) T 1WA5_B 164 AQTKVVVDADAVPLFIQLLY-TGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSN--------------- 227 (530) T ss_dssp HHHHHHHHTTCHHHHHHHHH-HCCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHGGGSC--------------- T ss_pred HHHHHHhcCChHHHHHHHHh-CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCcHHHHHHHhhCC--------------- Confidence 33333333466777777776 556788899999999988753 23333333 6777777776521 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) ++++...+..+|..-... ...........+++..|...+.. .+......+.. T Consensus 228 -~~~v~~~a~~~l~~l~~~---------------------~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~ 279 (530) T 1WA5_B 228 -KPSLIRTATWTLSNLCRG---------------------KKPQPDWSVVSQALPTLAKLIYS------MDTETLVDACW 279 (530) T ss_dssp -CHHHHHHHHHHHHHHHCC---------------------SSSCCCHHHHGGGHHHHHHHTTC------CCHHHHHHHHH T ss_pred -CHHHHHHHHHHHHHHHCC---------------------CCCCCCHHHHhhHHHHHHHHHhc------CCHHHHHHHHH Confidence 344444444443221100 00000011122334444333221 11111222222 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) .|.++... +......+.+.++++.|+.++. T Consensus 280 ~l~~l~~~--------------------------------------------------~~~~~~~~~~~~~~~~l~~~l~ 309 (530) T 1WA5_B 280 AISYLSDG--------------------------------------------------PQEAIQAVIDVRIPKRLVELLS 309 (530) T ss_dssp HHHHHHSS--------------------------------------------------CHHHHHHHHHTTCHHHHHHGGG T ss_pred HHHHHcCC--------------------------------------------------CHHHHHHHHhCCHHHHHHHHhc Confidence 22222110 0001112345567778888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQ 635 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~g 635 (747) ..++.++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++++|.+++... .. ..+...+ T Consensus 310 -~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~ 383 (530) T 1WA5_B 310 -HESTLVQTPALRAVGNIVTGNDL-----QTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDAN 383 (530) T ss_dssp -CSCHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTT T ss_pred -CCChhHHHHHHHHHHHHHhCCHH-----HHHHHHHCChHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCC Confidence 46777888999999998875332 1223344578888999988888889999999999998762 22 3334456 Q NP_000290.2 636 VFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP---QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMW 712 (747) Q Consensus 636 iI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~---e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~ 712 (747) +++.|..++.+ .++.++..++.+|.+++.... .....+.+.++++.|..++.+. ++.++..++.+|.+++ T Consensus 384 ~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~l~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~ 456 (530) T 1WA5_B 384 LIPPLVKLLEV------AEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIA-DNRIIEVTLDALENIL 456 (530) T ss_dssp CHHHHHHHHHH------SCHHHHHHHHHHHHHHHHHTTTCTHHHHHHHHTTCHHHHHHHTTTC-CHHHHHHHHHHHHHHH T ss_pred chHHHHHHHHc------CCHHHHHHHHHHHHHHHcCCCCCHHHHHHHHHCCCHHHHHHHccCC-CHHHHHHHHHHHHHHH Confidence 77888888876 367889999999999987532 2334444557788888888866 7788999999999998 Q NP_000290.2 713 SSKE 716 (747) Q Consensus 713 ~~~~ 716 (747) ...+ T Consensus 457 ~~~~ 460 (530) T 1WA5_B 457 KMGE 460 (530) T ss_dssp HHHH T ss_pred HHHH Confidence 7654 No 86 >1EE4_A KARYOPHERIN ALPHA; ARM repeat, TRANSPORT PROTEIN; 2.1A {Saccharomyces cerevisiae} SCOP: a.118.1.1 Probab=97.51 E-value=5.1e-08 Score=96.57 Aligned_cols=115 Identities=13% Similarity=0.098 Sum_probs=77.4 Template_Neff=13.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+....+.....+...++++.+...+.+.++.++..++.++..++......... T Consensus 87 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 166 (423) T 1EE4_A 87 DAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDW 166 (423) T ss_dssp THHHHHHHHHHHSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHHTTSCCHHHHHHHHHHHHHHHCCSTTCCCH T ss_pred ChHHHHHHHHhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCCCCCCh Confidence 34556666676777888889999999887654433333444467777888887777888888999998887644222222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ....++++.+...+. ..++.++..++.++..+... T Consensus 167 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 201 (423) T 1EE4_A 167 SVVSQALPTLAKLIY-SMDTETLVDACWAISYLSDG 201 (423) T ss_dssp HHHGGGHHHHHHHTT-CSCHHHHHHHHHHHHHHTSS T ss_pred HHHhhHHHHHHHHHH-cCCHHHHHHHHHHHHHHhcC Confidence 233455666666665 45567777778887777654 No 87 >1EE4_B KARYOPHERIN ALPHA; ARM repeat, TRANSPORT PROTEIN; 2.1A {Saccharomyces cerevisiae} SCOP: a.118.1.1 Probab=97.51 E-value=5.1e-08 Score=96.57 Aligned_cols=115 Identities=13% Similarity=0.098 Sum_probs=77.4 Template_Neff=13.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+....+.....+...++++.+...+.+.++.++..++.++..++......... T Consensus 87 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 166 (423) T 1EE4_B 87 DAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDW 166 (423) T ss_dssp THHHHHHHHHHHSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHGGGSCCHHHHHHHHHHHHHHHCCSSSCCCH T ss_pred ChHHHHHHHHhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCCCCCCh Confidence 34556666676777888889999999887654433333444467777888887777888888999998887644222222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ....++++.+...+. ..++.++..++.++..+... T Consensus 167 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 201 (423) T 1EE4_B 167 SVVSQALPTLAKLIY-SMDTETLVDACWAISYLSDG 201 (423) T ss_dssp HHHGGGHHHHHHHTT-CSCHHHHHHHHHHHHHHHSS T ss_pred HHHhhHHHHHHHHHH-cCCHHHHHHHHHHHHHHhcC Confidence 233455666666665 45567777778887777654 No 88 >4I2Z_A Protein UNC-45, Heat shock protein; chaperone, myosin folding, protein filaments; 2.9A {Caenorhabditis elegans} Probab=97.51 E-value=6.2e-08 Score=114.34 Aligned_cols=431 Identities=14% Similarity=0.098 Sum_probs=219.4 Template_Neff=8.600 Q NP_000290.2 248 PKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE--T 325 (747) Q Consensus 248 ~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~--l 325 (747) +.++.++.+.+..++..++.+|.......... ..+. ...++.|..++.+.++.++..++..|..+.......... . T Consensus 443 ~~l~~~~~~~~~~~~~~a~~~l~~~~~~~~~~-~~i~-~~~v~~L~~l~~~~~~~v~~~A~~~L~kL~~~~~~~~~~~~~ 520 (961) T 4I2Z_A 443 PIMLEMAASQDHLMQGIAAELIVATVSKHERA-INML-KVGIPVLRALYDSEDPTVKVRALVGLCKIGAAGGDDISKATM 520 (961) T ss_dssp HHHHHHHHSSCHHHHHHHHHHHHTTCCSSSSS-CHHH-HTHHHHHHHHHHCSSHHHHHHHHTTSSCC------------- T ss_pred HHHHHHhcCCCHHHHHHHHHHHHHHcChhHHH-HHHH-HhHHHHHHHHHhCCCHHHHHHHHHHHHHHHhcCCcchhhhcc Confidence 33334455556667777777777554332111 1122 235677777777778889999999999887643321110 1 Q NP_000290.2 326 ---RRQNGIREAVSLLRRT--GNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVIIPFSGWCDGNSNMSREVV 398 (747) Q Consensus 326 ---l~~~IL~~Ll~lL~ss--~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~~~~~~~~~~~~~~~~~~~ 398 (747) ....+...+..++... .+..++..++..|..+.........+.. ++++.|++++...-+...-| ++ T Consensus 521 ~~~~~~~L~~~~~~~l~~~~~~~~~~~~~A~e~Layls~~~~vke~l~~d~~~l~~L~~ll~~~~~~~~~~-------~~ 593 (961) T 4I2Z_A 521 KEEAVISLAKTCKKFLLETEKYSVDIRRYACEGLSYLSLDADVKEWIVDDSLLLKALVLLAKKAGALCVYT-------LA 593 (961) T ss_dssp ----CCHHHHHHHHHHHCTTTSCHHHHHHHHHHHHHHTTSHHHHHHHHHCHHHHHHHHHHHHHHGGGGSHH-------HH T ss_pred chHHHHHHHHHHHHHHhcCcCCChHHHHHHHHHHHHHhcCHHHHHHHhcCHHHHHHHHHHHHHcChhHHHH-------HH Confidence 0112344444555411 2456888999999999876655555554 68888888887542111111 00 Q NP_000290.2 399 DPEVFFNATGCL-RKRLG--MRELLALVPQRATSSRVNLSSADAGRQTMR--NYSGLIDSLMAYVQNCVAASRCDDKSVE 473 (747) Q Consensus 399 ~~~~~~~~~~~~-~~~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 473 (747) ..+-|-+... ++.+. |.+|..+..+.... ...+...+.-....+ --.|.+..|.+.+.. -+....+ T Consensus 594 --~~l~nl~~~~~~~~~~~e~~~l~~~a~~~~~~-~~~~d~~~~v~~r~~~l~~~g~~~~Lv~ll~~------~s~~~r~ 664 (961) T 4I2Z_A 594 --TIYANLSNAFEKPKVDEEMVKLAQFAKHHVPE-THPKDTEEYVEKRVRALVEEGAVPACVAVSKT------ESKNALE 664 (961) T ss_dssp --HHHHHHTTCCCCCC----------CCCCSSTT-CCTTSSTTHHHHHHHHHHHSCSHHHHHHTCCC------SCSHHHH T ss_pred --HHHHHHhcCCCCCCCCHHHHHHHHHHhcCCCC-CCcCCCHHHHHHHHHHHHHCCCHHHHHHHhcC------CCHHHHH Confidence 0111111100 00000 11222221111110 000111111111111 113445555444432 1233445 Q NP_000290.2 474 NCMCVLHNLSYRLDAEVPTRYRQLEYNARNAY-------TE---KSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWL 543 (747) Q Consensus 474 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-------~~---~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~l 543 (747) .+..++++++-.- + .|-.-.+..+-..- ++ .....+..+-.. .-+..+.+... T Consensus 665 ~~~~~l~~l~~~~--~--~R~~iv~~G~v~~Ll~ll~~~~~~~~~~Aa~ALa~l~~-----~~~p~~~~~~~-------- 727 (961) T 4I2Z_A 665 LIARSLLAFAEYE--D--LRGRIIAEGGTVLCLRLTKEASGEGKIKAGHAIAKLGA-----KADPMISFPGQ-------- 727 (961) T ss_dssp HHHHHHHTTSCSS--T--THHHHTTTTHHHHHHHHHHHSCTHHHHHHHHHHHHHSS-----SSCSTTTSTTT-------- T ss_pred HHHHHHHHHhCCH--H--HHHHHHHCchHHHHHHHHhcCChHHHHHHHHHHHHHHc-----cCChhhhcCCc-------- Confidence 5666777776211 1 11110111100000 00 000000000000 00000111111 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLSNM 622 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-s~d~eVr~~AL~aLsnL 622 (747) ...++++.|+.+|..+.+...+..++.+|.+|+..++. ....+.+.++++.|..+|. +.++.++..|+.++.+| T Consensus 728 ~~~~~i~pLv~lL~~~~~~~~~~eal~ALtnLa~~~~~-----~~~~I~~~~~~~~l~~lL~~~~~~~vr~aA~ell~nL 802 (961) T 4I2Z_A 728 RAYEVVKPLCDLLHPDVEGKANYDSLLTLTNLASVSDS-----IRGRILKEKAIPKIEEFWFMTDHEHLRAAAAELLLNL 802 (961) T ss_dssp HHHHTTSHHHHTTSCCSSCTTHHHHHHHHHHHHSSCHH-----HHHHHHHTTCHHHHGGGTSCSSCHHHHHHHHHHHHHS T ss_pred chhhHHHHHHHHhCCCCChHHHHHHHHHHHHHHcCCHH-----HHHHHHhcChHHHHHHHHhcCCCHHHHHHHHHHHHHH Confidence 01267899999987334556778899999999986533 3445566788999999888 77889999999999999 Q NP_000290.2 623 SRHPLL-HRVM--GNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSS--SMLNNIINLCRSSAS 697 (747) Q Consensus 623 a~~~e~-~~ll--~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~--giL~~Ll~LL~s~~d 697 (747) +.++.. ..+. ..+.+..++.++.+. .+..++..|+.+|..++. .+.....+++. +.+..+..++.+. + T Consensus 803 ~~~~~~~~~~~~~~~~~~~ll~~l~~~~-----~d~~~~~aA~~aLa~ls~-~~~~~~~i~~~~~~~~~il~~ll~~~-~ 875 (961) T 4I2Z_A 803 LFFEKFYEETVAPGTDRLKLWVLYSAEV-----EEERLSRASAAGFAILTE-DENACARIMDEIKSWPEVFKDIAMHE-D 875 (961) T ss_dssp SSSTTSSTTTTSSCCTHHHHHHHHHHSC-----SSSTHHHHHHHHHHHHHT-CHHHHHHHTTTCTTHHHHHHHHHHCS-S T ss_pred HcCHHHHHhhCCCCCccchhhhHHhccC-----CCHHHHHHHHHHHHHHhC-CHHHHHHHHHHHhchHHHHHHHhhCC-C Confidence 976544 2221 223444454443331 367888999999999884 46655555553 3466677777666 7 Q NP_000290.2 698 PKAAEAARLLLSDMWS-SKELQGVLRQQG 725 (747) Q Consensus 698 ~eVr~aAL~aLsnL~~-~~~~~~~~~~~~ 725 (747) +.++..++.+|.+++. +.++...+-+.| T Consensus 876 ~~l~~ra~~~L~nl~~~~~~~~~~i~~~g 904 (961) T 4I2Z_A 876 AETQRRGLMGIANIMHSSNKLCSEIVSSE 904 (961) T ss_dssp TTHHHHHHHHHTTTSSSCHHHHTCCTTHH T ss_pred HHHHHHHHHHHHHHHhcCHHHHHHHHhcc Confidence 8899999999999965 444444343344 No 89 >5XZX_A Importin subunit alpha-3, Ran-binding protein; nuclear import, TRANSPORT PROTEIN; 3.0A {Homo sapiens} Probab=97.48 E-value=6.3e-08 Score=95.65 Aligned_cols=360 Identities=17% Similarity=0.182 Sum_probs=211.7 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+. ..++.++..++.++..++...+.....+...++++.+...+.+.++.++..++.++..++...+..... T Consensus 46 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 125 (416) T 5XZX_A 46 ILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDY 125 (416) T ss_dssp CHHHHHHHTTCTTCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHH T ss_pred cHHHHHHHhcCCCCHHHHHHHHHHHHHHhcCChHHHHHHHhcChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 4555666665 456678888888888887654433333334567777888887777888999999999887654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...+++..+...+....++.++..++.++..++.......... .++++.+..++.. .++++ T Consensus 126 ~~~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~~ 189 (416) T 5XZX_A 126 VISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHH----------------TDVNI 189 (416) T ss_dssp HHHHTCHHHHTTSCSTTSCHHHHHHHHHHHHHHHHCCSSCCCHHHHHHHHHHHHHHTTC----------------CCHHH T ss_pred HHHCccHHHHHHhcCCCCCHHHHHHHHHHHHHHhcCCCCCCChhHHHHHHHHHHHHHhC----------------CCHHH Confidence 33345667777776533456778888888888876533211111 1566666666542 13444 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..++..-... .+ .....+ --.+++..+...++. -+..-...+...|.++ T Consensus 190 ~~~a~~~l~~l~~~------~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l 242 (416) T 5XZX_A 190 LVDTVWALSYLTDA------GN--------------EQIQMV-IDSGIVPHLVPLLSH------QEVKVQTAALRAVGNI 242 (416) T ss_dssp HHHHHHHHHHHHHH------CH--------------HHHHHH-HHHTCHHHHGGGGGC------SCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhhc------CH--------------HHHHHH-HHCChHHHHHHHcCC------CCHHHHHHHHHHHHHH Confidence 44444333221100 00 000000 001334444333321 0111111222222222 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) ...- ......+.+.++++.+..++. +.++ T Consensus 243 ~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~ 271 (416) T 5XZX_A 243 VTGT--------------------------------------------------DEQTQVVLNCDALSHFPALLT-HPKE 271 (416) T ss_dssp TTSC--------------------------------------------------HHHHHHHHTTTCGGGSHHHHT-CSCH T ss_pred HcCC--------------------------------------------------HHHHHHHcCcccHHHHHHHhc-CCCH Confidence 1100 001111234467788888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGNQVFPE 639 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~giI~~ 639 (747) .++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++.. . .. ..+...++++. T Consensus 272 ~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~ 346 (416) T 5XZX_A 272 KINKEAVWFLSNITAGNQQ-----QVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPP 346 (416) T ss_dssp HHHHHHHHHHHHHTTSCHH-----HHHHHHTTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHH T ss_pred HHHHHHHHHHHHHhcCCHH-----HHHHHHhCCHHHHHHHHHHcCCHHHHHHHHHHHHHHHHhcCHHHHHHHHHCCCHHH Confidence 8888999999998765332 223334556888888888888888999999999999864 2 11 22334567788 Q NP_000290.2 640 VTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA----KQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDM 711 (747) Q Consensus 640 Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~----~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL 711 (747) +..++.+ .++.++..++.+|.+++...+... ..+.+.++++.+..++.+. ++.++..++.+|.++ T Consensus 347 l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~~ 415 (416) T 5XZX_A 347 FCNLLTV------KDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHE-NEDIYKLAYEIIDQF 415 (416) T ss_dssp HHTTTTS------SCHHHHHHHHHHHHHHHHHCSTTHHHHHHHHHHTTHHHHHHTTCCTT-CHHHHHHHHHHHHHH T ss_pred HHHHccC------CCHHHHHHHHHHHHHHHHHhHHhHHHHHHHHHHcCHHHHHHHHhhCC-cHHHHHHHHHHHHHh Confidence 8888776 367888899999999987533211 1233345677888888766 778888888887764 No 90 >5MFO_F YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: CA, EDO; 1.3A {synthetic construct} Probab=97.46 E-value=6.9e-08 Score=85.28 Aligned_cols=134 Identities=25% Similarity=0.287 Sum_probs=89.4 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++..+..++...+.....+...++++.+...+.+.++.++..++.++..++.........+ T Consensus 5 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 84 (202) T 5MFO_F 5 ELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 84 (202) T ss_dssp THHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 34556666666777888889999988876544444444445677888888887778888999999999886544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 85 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 140 (202) T 5MFO_F 85 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLS 140 (202) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhc Confidence 34456777777776 4566778888888888876422 2222223 55666666554 No 91 >3SL9_E Catenin beta-1, B-cell CLL/lymphoma 9; Armadillo repeat, components of the; HET: PEG, GOL, IMD, EDO; 2.2A {Homo sapiens} Probab=97.46 E-value=7.2e-08 Score=83.64 Aligned_cols=134 Identities=16% Similarity=0.201 Sum_probs=88.4 Template_Neff=12.600 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLG-GICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~-IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .+++.+...+.+.++.++..++.++.++..... ....+.... +++.+..++.. .+..++..++.++..++.. .... T Consensus 13 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~-~~~~ 90 (167) T 3SL9_E 13 RAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEA-SRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHH-REGL 90 (167) T ss_dssp HHHHHHHHHHTCSCHHHHHHHHHHHHHHTTSHH-HHHHHHTCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTS-HHHH T ss_pred CcHHHHHHHhCCCCHHHHHHHHHHHHHHccCHH-HHHHHHhCCchHHHHHHHHhcCCCHHHHHHHHHHHHHHcCC-HhHH Confidence 345556666666667788889999998876543 222233323 77777777776 6677888889999888743 3333 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVII 381 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~~ 381 (747) ..+...+.++.+..++. ..++.++..++.++.+++.........+. ++++.|++++.. T Consensus 91 ~~~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~ 150 (167) T 3SL9_E 91 LAIFKSGGIPALVKMLG-SPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNK 150 (167) T ss_dssp HHHHHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHCTTHHHHHHHTTHHHHHHHHHHH T ss_pred HHHHHCCcHHHHHHHhC-CCCHHHHHHHHHHHHHHHcCCHhHHHHHHHcCHHHHHHHHhcC Confidence 33444567777888776 55677888899999998875433333332 667777777654 No 92 >3NOW_A SD10334p; Armadillo Repeat, Hsp90, Myosin, Tetra-tricopeptide; 2.992A {Drosophila melanogaster} Probab=97.46 E-value=7.3e-08 Score=105.35 Aligned_cols=110 Identities=10% Similarity=0.050 Sum_probs=66.2 Template_Neff=12.800 Q NP_000290.2 247 IPKAVQYLSSQ--DEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 247 L~~Ll~lL~ss--d~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) +..++..+.+. +..++..++..|..++... .........+.++.+...+.. .+..++..++.++..++........ T Consensus 8 i~~l~~~l~~~~~~~~~r~~a~~~l~~l~~~~-~~~~~~~~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~~~~~~~~~ 86 (810) T 3NOW_A 8 VKQMMDLTFDLATPIDKRRAAANNLVVLAKEQ-TGAELLYKDHCIAKVASLTKVEKDQDIYVNMVHLVAALCENSVERTK 86 (810) T ss_dssp HHHHHHHHHSSCCSSHHHHHHHHHHHHHSSCH-HHHHHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHHTTCHHHHH T ss_pred HHHHHHHHhcCCCcHHHHHHHHHHHHHHhccc-cccHHHHccccHHHHHHHhcCCCCHHHHHHHHHHHHHHHHcCHhHHH Confidence 33445555554 5778888888888887654 222223334567777777731 5678888999999888765332222 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) .......++.+...+. ..++.++..++.++..++ T Consensus 87 ~~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~~~ 120 (810) T 3NOW_A 87 GVLTELGVPWFMRVLD-QKHENCVSTAQFCLQTIL 120 (810) T ss_dssp HHHHHSCHHHHHHHHH-CCSTTHHHHHHHHHHHHH T ss_pred HHHHHhcHHHHHHHhc-CCChhHHHHHHHHHHHHH Confidence 2222334566666665 345556666666666554 No 93 >5MFO_E YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: EDO, CA; 1.3A {synthetic construct} Probab=97.44 E-value=7.9e-08 Score=84.90 Aligned_cols=134 Identities=25% Similarity=0.287 Sum_probs=89.3 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++..+..++...+.....+...++++.+...+.+.++.++..++.++..++.........+ T Consensus 5 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 84 (202) T 5MFO_E 5 ELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 84 (202) T ss_dssp CHHHHHHHTTCSSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHHHHHHCChHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 34556666666777888889999988876544434444445677888888887788889999999999886544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 85 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 140 (202) T 5MFO_E 85 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLS 140 (202) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhc Confidence 34456777777775 4566778888888888876422 2222223 55666666554 No 94 >4XZR_B Heh1-NLS, Kap60; karyopherins nuclear import ; 2.25A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=97.44 E-value=8.1e-08 Score=95.04 Aligned_cols=115 Identities=13% Similarity=0.098 Sum_probs=77.3 Template_Neff=13.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.++.++..++.++..++......... T Consensus 87 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~ 166 (423) T 4XZR_B 87 DAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDW 166 (423) T ss_dssp TCHHHHHHHHHHSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCHHHHHHHTTSCCHHHHHHHHHHHHHHHCCCTTCCCH T ss_pred chHHHHHHHHhCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCcHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCCCCCCh Confidence 34556666677777888899999999887654433333444467777888887777888888999998887654222222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ....++++.+...+. ..++.++..++.++..++.. T Consensus 167 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 201 (423) T 4XZR_B 167 SVVSQALPTLAKLIY-SMDTETLVDACWAISYLSDG 201 (423) T ss_dssp HHHGGGHHHHHHHTT-CSCHHHHHHHHHHHHHHTSS T ss_pred HHhccHHHHHHHHhh-CCCHHHHHHHHHHHHHHhcC Confidence 233346666666665 44566777777777777654 No 95 >3OPB_A SWI5-dependent HO expression protein 4; HEAT and ARM fold, Myosin; 2.9A {Saccharomyces cerevisiae} Probab=97.44 E-value=9.1e-08 Score=108.58 Aligned_cols=168 Identities=20% Similarity=0.242 Sum_probs=116.3 Template_Neff=10.500 Q NP_000290.2 546 SDAIRTYLNLMGKSK-------------KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVV 612 (747) Q Consensus 546 ~G~I~~LL~LL~ss~-------------d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr 612 (747) .++++.|+.++.... +..++..++.+|.+++.......+......+...++++.|..++.+.++.++ T Consensus 544 ~~~l~~L~~lL~~~~~~~~~~~~~~~~~~~~~~~~al~aL~~l~~~~~~~~~~~~~~~~~~~~~~~~L~~ll~~~~~~v~ 623 (778) T 3OPB_A 544 LNAIPFLFELLPRSTPVDDNPLHNDEQIKLTDNYEALLALTNLASSETSDGEEVCKHIVSTKVYWSTIENLMLDENVPLQ 623 (778) T ss_dssp TTHHHHHHHTSCCSSSCSSCC---CCCCCHHHHHHHHHHHHHHHHCCSHHHHHHHHHHHHSHHHHHHHHHGGGCSSHHHH T ss_pred cchHHHHHHHCCCCCCCCCCCCCChhhccHHHHHHHHHHHHHHhcCCCCCCHHHHHHHHhcccHHHHHHHHhhCCCHHHH Confidence 456677777765211 4567778999999988752200000011222224688888888888888899 Q NP_000290.2 613 RSGASLLSNMSRHPLL--HRVMGN------QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFS-SS 683 (747) Q Consensus 613 ~~AL~aLsnLa~~~e~--~~ll~~------giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve-~g 683 (747) ..++.+|++++..... ..++.. ++++.|+.++.. .+..++..++++|++++...+.....++. .+ T Consensus 624 ~~a~~~L~~L~~~~~~~~~~~~~~~~~~~~~~l~~L~~ll~~------~~~~v~~~a~~~L~~l~~~~~~~~~~l~~~~~ 697 (778) T 3OPB_A 624 RSTLELISNMMSHPLTIAAKFFNLENPQSLRNFNILVKLLQL------SDVESQRAVAAIFANIATTIPLIAKELLTKKE 697 (778) T ss_dssp HHHHHHHHHHHTSGGGTGGGTSCCSSHHHHHHHHHHHHGGGC------SCHHHHHHHHHHHHHHHHHCHHHHHHHTTCHH T ss_pred HHHHHHHHHHhcChhHHHHHhcCCCChhHHHhHHHHHHHhcC------CCHHHHHHHHHHHHHHHccCHHHHHHHhcCcc Confidence 9999999999987432 233332 678888888876 36789999999999997655554444443 67 Q NP_000290.2 684 MLNNIINLCRSS-ASPKAAEAARLLLSDMWSSKELQG 719 (747) Q Consensus 684 iL~~Ll~LL~s~-~d~eVr~aAL~aLsnL~~~~~~~~ 719 (747) +++.|+.++.+. .+..++..++++|.+++...+... T Consensus 698 ~i~~L~~~L~~~~~~~~l~~~a~~aL~~L~~~~~~~~ 734 (778) T 3OPB_A 698 LIENAIQVFADQIDDIELRQRLLMLFFGLFEVIPDNG 734 (778) T ss_dssp HHHHHHHHHHHTTTCHHHHHHHHHHHHHHHTTCCSTT T ss_pred HHHHHHHHHHhCCCCHHHHHHHHHHHHHHHhhCCcCC Confidence 889999998862 167789999999999997766544 No 96 >4I2W_A Protein UNC-45, Heat shock 70; chaperone, myosin folding, protein filaments; 3.6A {Caenorhabditis elegans} Probab=97.43 E-value=1e-07 Score=112.49 Aligned_cols=433 Identities=14% Similarity=0.102 Sum_probs=221.5 Template_Neff=8.600 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE-- 324 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~-- 324 (747) ++.++.++.+.+..++..++.+|..+....... ..+. ...++.|..++.+.++.++..++..|..+.......... T Consensus 442 ~~~l~~l~~~~~~~~~~~a~~~l~~~~~~~~~~-~~i~-~~~v~~L~~l~~~~~~~v~~~A~~~L~kL~~~~~~~~~~~~ 519 (961) T 4I2W_A 442 TPIMLEMAASQDHLMQGIAAELIVATVSKHERA-INML-KVGIPVLRALYDSEDPTVKVRALVGLCKIGAAGGDDISKAT 519 (961) T ss_dssp HHHHHHHHHSSCHHHHHTTTTTTTTTCCSCSSS-HHHH-HHHHHHHHHHHHCSCHHHHHHHHTTSSSCCC---------- T ss_pred HHHHHHHhcCCCHHHHHHHHHHHHHHcChhHHH-HHHH-HhHHHHHHHHHhCCCHHHHHHHHHHHHHHHhcCCcchhhhc Confidence 333334455556667777777777554332111 1122 235677777777778889999999999887543321100 Q NP_000290.2 325 T---RRQNGIREAVSLLRRT--GNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 325 l---l~~~IL~~Ll~lL~ss--~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) . ....+...+..++... .+..++..++..|..+.........+.. .+++.|++++...-+...-|- T Consensus 520 ~~~~~~~~l~~~~~~~l~~~~~~~~~~~~~AvegLayLs~~~~vke~l~~d~~~l~~L~~ll~~~~~~~~~~~------- 592 (961) T 4I2W_A 520 MKEEAVISLAKTCKKFLLETEKYSVDIRRYACEGLSYLSLDADVKEWIVDDSLLLKALVLLAKKAGALCVYTL------- 592 (961) T ss_dssp --CCCTTHHHHHHHHHHHCCSSSCHHHHHHHHHHHHHTCSSHHHHHHHHHCHHHHHHHHHHHHHHGGGSHHHH------- T ss_pred cchHHHHHHHHHHHHHHhcCcCCChHHHHHHHHHHHHHhcCHHHHHHHhcCHHHHHHHHHHHHHcChhHHHHH------- Confidence 1 0112344455555411 2456888999999999876655555554 688889888875422111111 Q NP_000290.2 398 VDPEVFFNATGCL-RKRL--GMRELLALVPQRATSSRVNLSSADAGRQTMRN--YSGLIDSLMAYVQNCVAASRCDDKSV 472 (747) Q Consensus 398 ~~~~~~~~~~~~~-~~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~ 472 (747) + ..+-|-+... ++.+ .|.+|..+..+..... ..+...+.-....+. -.|.+..|.+.+.. -+.... T Consensus 593 ~--~~l~nl~~~~~~~~~~~e~~~l~~~a~~~~~~~-~~~d~~~~v~~r~~~l~~~g~~~~Lv~ll~~------~s~~~r 663 (961) T 4I2W_A 593 A--TIYANLSNAFEKPKVDEEMVKLAQFAKHHVPET-HPKDTEEYVEKRVRALVEEGAVPACVAVSKT------ESKNAL 663 (961) T ss_dssp H--HHHHHTTTCCCCCC----------CCCCCSTTC-TTTTSSTTHHHHHHHHHHSSSSHHHHHTTCC------CCSHHH T ss_pred H--HHHHHHhcCCCCCCCCHHHHHHHHHHhcCCCCC-CcCCCHHHHHHHHHHHHHCCCHHHHHHHhcC------CCHHHH Confidence 0 0111111110 0000 0122222211111110 011111111111111 12444444444332 122334 Q NP_000290.2 473 ENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAY---T-E------KSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGW 542 (747) Q Consensus 473 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~---~-~------~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~ 542 (747) +.+..+|++++-.- +. |-.-.+..+-..- . + .....+..+-.. .-+..+.+... T Consensus 664 ~~~~~~l~~l~~~~--~~--R~~ivq~g~~~~Ll~ll~~~~~~~~~~Aa~ALa~l~~-----~~~p~~~~~~~------- 727 (961) T 4I2W_A 664 ELIARSLLAFAEYE--DL--RGRIIAEGGTVLCLRLTKEASGEGKIKAGHAIAKLGA-----KADPMISFPGQ------- 727 (961) T ss_dssp HHHHHHHHTTSSSS--TT--TTTTTTSSHHHHHHHHHHHSTTHHHHHHHHHHHTTSS-----SSCGGGTSTTT------- T ss_pred HHHHHHHHHHhCCH--HH--HHHHHHCchHHHHHHHHhcCChHHHHHHHHHHHHHHc-----cCChhhhcCCc------- Confidence 55566777776211 11 1000001100000 0 0 000000000000 00000111111 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLSN 621 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-s~d~eVr~~AL~aLsn 621 (747) ...++++.|+.+|..+.+...+..++.+|.+|+..++. ....+.+.++++.|..+|. +.++.++..|+.++.+ T Consensus 728 -~~~~~i~pLv~lL~~~~~~~~~~eal~ALtnLa~~~~~-----~~~~I~~~~~~~~l~~lL~~~~~~~vr~aA~ell~n 801 (961) T 4I2W_A 728 -RAYEVVKPLCDLLHPDVEGKANYDSLLTLTNLASVSDS-----IRGRILKEKAIPKIEEFWFMTDHEHLRAAAAELLLN 801 (961) T ss_dssp -HHHHTTSGGGTSSSCCSSCTTTTTTHHHHHHHSSSCHH-----HHHHHHHTTCHHHHTTSSSCSTTHHHHHHHHHHHHT T ss_pred -chhhHHHHHHHHhCCCCChHHHHHHHHHHHHHHcCCHH-----HHHHHHhcChHHHHHHHHhcCCCHHHHHHHHHHHHH Confidence 11267899999987334556778899999999986533 3445556788899998888 7788999999999999 Q NP_000290.2 622 MSRHPLL-HRVM--GNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSS--SMLNNIINLCRSSA 696 (747) Q Consensus 622 La~~~e~-~~ll--~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~--giL~~Ll~LL~s~~ 696 (747) |+.++.. ..+. ..+.+..++.++.+. .++.++..|+.+|+.++. .+.....+++. +.+..|..++.+. T Consensus 802 L~~~~~~~~~~~~~~~~~~~ll~~l~~~~-----~d~~~~~aA~~aLa~l~~-~~~~~~~i~~~~~~~~~~l~~ll~~~- 874 (961) T 4I2W_A 802 LLFFEKFYEETVAPGTDRLKLWVLYSAEV-----EEERLSRASAAGFAILTE-DENACARIMDEIKSWPEVFKDIAMHE- 874 (961) T ss_dssp TSSSSSSSTTTSSSCSSCHHHHHHHHHCC-----SSSTHHHHHHHHHHHHHS-SHHHHHHTGGGCTTHHHHHHHHHHCS- T ss_pred HHcCHHHHHhhCCCCCccchhhhHHhccC-----CCHHHHHHHHHHHHHHhC-CHHHHHHHHHHHhchHHHHHHHhhCC- Confidence 9976544 2221 223444444443331 357888999999999884 45555555553 3466677777666 Q NP_000290.2 697 SPKAAEAARLLLSDMWS-SKELQGVLRQQGF 726 (747) Q Consensus 697 d~eVr~aAL~aLsnL~~-~~~~~~~~~~~~~ 726 (747) ++.++..++.+|.+++. +.+....+.+.|. T Consensus 875 ~~~l~~ra~~~l~nl~~~~~~~~~~~~~~g~ 905 (961) T 4I2W_A 875 DAETQRRGLMGIANIMHSSNKLCSEIVSSEV 905 (961) T ss_dssp STTHHHHHHHHTHHHHSSCSHHHHCCSSHHH T ss_pred CHHHHHHHHHHHHHHHhcCHHHHHHHHhccH Confidence 78899999999999965 4444443444443 No 97 >3TT9_A Plakophilin-2; CELL ADHESION; HET: GOL; 1.55A {Homo sapiens} Probab=97.42 E-value=9.1e-08 Score=88.50 Aligned_cols=221 Identities=45% Similarity=0.773 Sum_probs=134.5 Template_Neff=12.300 Q NP_000290.2 245 LTIPKAVQYLSSQD--EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd--~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) ..++.++..+...+ ..++..++.++.+++.........+...++++.+..++...+..++..++.+|.+++....... T Consensus 8 ~~i~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~ 87 (233) T 3TT9_A 8 MTLERAVSMLEADHMLPSRISAAATFIQHECFQKSEARKRVNQLRGILKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNK 87 (233) T ss_dssp CCHHHHHHTCCSSCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHTTHHHHHHHGGGCCCHHHHHHHHHHHHHHHTTCHHHH T ss_pred hHHHHHHHHHhhcCCCHHHHHHHHHHHHHHHccCHHHHHHHHHcchHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCCcHH Confidence 34556666666544 6788888899988876444444445555678888888877777888999999999886444444 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPE 401 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~ 401 (747) ..+...+.++.++.++....+..++..++.++.+++........+.. +++..+..++.... .+-.....+.....+++ T Consensus 88 ~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~ll~~~~-~~~~~~~~~~~~~~~~~ 166 (233) T 3TT9_A 88 LEVAELNGVPRLLQVLKQTRDLETKKQITGLLWNLSSNDKLKNLMITEALLTLTENIIIPFS-GWPEGDYPKANGLLDFD 166 (233) T ss_dssp HHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHHTSGGGHHHHHHHHHHHHCCCCCHHHH-CCCGGGCCCCCTTCCHH T ss_pred HHHHHcccHHHHHHHHhhCCCHHHHHHHHHHHHHHccCHHHHHHhhhhcHHHHHHHHHhhcc-CCCCCCCCcccCCCcHH Confidence 44445567777887775234567888999999999875544444444 66666666665432 11111222222334566 Q NP_000290.2 402 VFFNATGCLRKRLGMRELLALVPQRATSSRVNLSS-ADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLH 480 (747) Q Consensus 402 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 480 (747) +...+.++|.. +.. .+..++.+....++++.|...++....-...+.+-.+++..+|. T Consensus 167 ~~~~a~~~l~~---------------------l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~L~ 225 (233) T 3TT9_A 167 IFYNVTGCLRN---------------------MSSAGADGRKAMRRCDGLIDSLVHYVRGTIADYQPDDKATENCVCILH 225 (233) T ss_dssp HHHHHHHHHHH---------------------HTTSCHHHHHHHHTSTTHHHHHHHHHHHHHHTTCTTCHHHHHHHHHHH T ss_pred HHHHHHHHHHH---------------------HHhcCHHHHHHHHHcccHHHHHHHHHHcccccCCCChHHHHHHHHHHH Confidence 65555555432 111 22334444444455666666554421101115567788999999 Q NP_000290.2 481 NLSYRLD 487 (747) Q Consensus 481 ~~~~~~~ 487 (747) ||+++.+ T Consensus 226 ~l~~~~~ 232 (233) T 3TT9_A 226 NLSYQLE 232 (233) T ss_dssp HHCCCCC T ss_pred Hhhhccc Confidence 9987654 No 98 >2Z6H_A Catenin beta-1; Beta-Catenin, C-terminal Domain, Activator, Cell; 2.2A {Homo sapiens} Probab=97.42 E-value=9.4e-08 Score=103.88 Aligned_cols=378 Identities=17% Similarity=0.155 Sum_probs=229.8 Template_Neff=11.700 Q NP_000290.2 241 ECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRST 319 (747) Q Consensus 241 ~~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~ 319 (747) +....+++.+...+.+.++.++..++.++..+..............+++..+...+. ..+..++..++.+|..++.... T Consensus 10 ~~~~~~i~~L~~~l~~~~~~vr~~a~~~L~~l~~~~~~~~~~~~~~~~i~~L~~~l~~~~~~~v~~~a~~~L~~l~~~~~ 89 (644) T 2Z6H_A 10 ELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHRE 89 (644) T ss_pred HHhCCHHHHHHHHcCCCCHHHHHHHHHHHHHHhCCcHHHHHHHhCCChHHHHHHHHcCCCCHHHHHHHHHHHHHHhCCHH Confidence 344566777888888778889999999999887653222111111346666777666 4566788888888888865432 Q NP_000290.2 320 TNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELK-EELIA-DALPVLADRVIIPFSGWCDGNSNMSREV 397 (747) Q Consensus 320 ~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~-~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~ 397 (747) ....+...+.++.+...+. ..++.++..++.++..++...... ..+.. ++++.|+.++... T Consensus 90 -~~~~~~~~~~i~~L~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~L~~~l~~~--------------- 152 (644) T 2Z6H_A 90 -GLLAIFKSGGIPALVKMLG-SPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKT--------------- 152 (644) T ss_pred -HHHHHHHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHhcCC--------------- Confidence 2223333467777888876 556788889999999988653322 22222 6677777766531 Q NP_000290.2 398 VDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMC 477 (747) Q Consensus 398 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 477 (747) ++++...+..+|..-.... ...+..... .++++.|...+... .+.+....++. T Consensus 153 -~~~~~~~a~~~L~~l~~~~--------------------~~~~~~~~~-~~~~~~L~~~l~~~-----~~~~~~~~a~~ 205 (644) T 2Z6H_A 153 -NVKFLAITTDCLQILAYGN--------------------QESKLIILA-SGGPQALVNIMRTY-----TYEKLLWTTSR 205 (644) T ss_pred -CHHHHHHHHHHHHHHhcCC--------------------HHHHHHHHH-CCcHHHHHHHhcCC-----CCHHHHHHHHH Confidence 3344444444443211000 000111111 23444444444321 12222233333 Q NP_000290.2 478 VLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMG 557 (747) Q Consensus 478 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ 557 (747) +|.+++..- .....+.+.++++.|+.++. T Consensus 206 ~L~~l~~~~---------------------------------------------------~~~~~~~~~~~l~~l~~~l~ 234 (644) T 2Z6H_A 206 VLKVLSVCS---------------------------------------------------SNKPAIVEAGGMQALGLHLT 234 (644) T ss_pred HHHHHccCh---------------------------------------------------HHHHHHHHCCHHHHHHHHhc Confidence 333332110 00012345667888888887 Q NP_000290.2 558 KSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQ 635 (747) Q Consensus 558 ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~g 635 (747) ..+..++..++++|.+++..... ... ..++++.|+.++.+.+..++..++.+|.+++.. ... ..+...+ T Consensus 235 -~~~~~~~~~a~~~L~~l~~~~~~------~~~--~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~ 305 (644) T 2Z6H_A 235 -DPSQRLVQNCLWTLRNLSDAATK------QEG--MEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVG 305 (644) T ss_pred -CCCHHHHHHHHHHHHHHhcCCCC------HHH--HCchHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCHHHHHHHHhCC Confidence 46778888999999999875321 111 256788888888888888999999999999865 222 2334556 Q NP_000290.2 636 VFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL---AKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMW 712 (747) Q Consensus 636 iI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~---~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~ 712 (747) +++.++..+... ..+..++..++.+|.+++...+.. ...+...++++.|+.++....+..++..++.+|.+++ T Consensus 306 ~l~~L~~~l~~~----~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~v~~~a~~~L~~l~ 381 (644) T 2Z6H_A 306 GIEALVRTVLRA----GDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLA 381 (644) T ss_pred HHHHHHHHHhcC----CCCHHHHHHHHHHHHHHHcCCCCHHHHHHHHHHCCcHHHHHHHhcCCCCHHHHHHHHHHHHHHh Confidence 777777776521 035678889999999998753322 2333344677888888875435678899999999999 Q NP_000290.2 713 SSKELQGVLRQQGF 726 (747) Q Consensus 713 ~~~~~~~~~~~~~~ 726 (747) ...+.+..+.+.|. T Consensus 382 ~~~~~~~~l~~~~~ 395 (644) T 2Z6H_A 382 LCPANHAPLREQGA 395 (644) T ss_pred cCHHHHHHHHHCCc Confidence 87776655555443 No 99 >4U2X_E eVP24, KPNA5C; eVP24, importin alpha6, immune antagonist; 3.153A {Zaire ebolavirus} Probab=97.42 E-value=9.4e-08 Score=83.77 Aligned_cols=116 Identities=17% Similarity=0.149 Sum_probs=80.4 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFR-STTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~-~~~~~~~ 324 (747) +++.+..++.+.++.++..++.++.++....+.....+...++++.+...+.+.+..++..++.++.+++.. ....... T Consensus 9 ~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 88 (175) T 4U2X_E 9 ALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRY 88 (175) T ss_dssp SSHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHH T ss_pred hHHHHHHHHhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHhCChHHHHHHHHHhcCHHHHHHHHHHHHHHcCCCCHHHHHH Confidence 455566666667788889999999998865443333444456777888887777778888899999988753 2222223 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~ 362 (747) +...+.++.+...+. ..++.++..++.++.+++.... T Consensus 89 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~ 125 (175) T 4U2X_E 89 LVALGCIKPLCDLLT-VMDSKIVQVALNGLENILRLGE 125 (175) T ss_dssp HHHHTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHHHHH T ss_pred HHHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHHHhhcH Confidence 333456777777776 5567788888899888887543 No 100 >4RV1_D Engineered Protein OR497; STRUCTURAL GENOMICS, PSI-BIOLOGY, PROTEIN STRUCTURE; 2.573A {SYNTHETIC CONSTRUCT} Probab=97.42 E-value=9.1e-08 Score=94.28 Aligned_cols=363 Identities=20% Similarity=0.249 Sum_probs=217.4 Template_Neff=13.300 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.++.++..++.++..+........... T Consensus 45 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 124 (420) T 4RV1_D 45 GVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAI 124 (420) T ss_dssp HHHHHHHTTSCSCSSSHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHcCCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHhCCChHHHHHH Confidence 45556666666777888899999988876543333333334567777777777778888899999988876543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) ...++++.+...+. ..++.++..++.++..++..... ...+.. ++++.+..++... ++++- T Consensus 125 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~~~ 187 (420) T 4RV1_D 125 VDAGGVEVLVKLLT-STDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTST----------------DSEVQ 187 (420) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCS----------------SHHHH T ss_pred HHcCHHHHHHHHHh-CCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCHHHHHHHHhcCC----------------CHHHH Confidence 33456777777776 55677888899999988864322 222222 5566666655421 23332 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++.. +.. ........-.-.++++.+...+++ -+..-...+...|.++. T Consensus 188 ~~~~~~l~~---------l~~------------~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~ 240 (420) T 4RV1_D 188 KEAARALAN---------IAS------------GPTSAIKAIVDAGGVEVLVKLLTS------TDSEVQKEAARALANIA 240 (420) T ss_dssp HHHHHHHHH---------HHT------------SCHHHHHHHHTTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHH T ss_pred HHHHHHHHH---------HhC------------CCHHHHHHHHHCCHHHHHHHHhhC------CCHHHHHHHHHHHHHHh Confidence 222222221 100 000000000001233333322221 01111122222222221 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ... ......+.+.++++.++..+. +.++. T Consensus 241 ~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~~ 269 (420) T 4RV1_D 241 SGP--------------------------------------------------DEAIKAIVDAGGVEVLVKLLT-STDSE 269 (420) T ss_dssp TSC--------------------------------------------------HHHHHHHHHTTHHHHHHHHTT-CSSHH T ss_pred CCC--------------------------------------------------HHHHHHHhhccHHHHHHHHhC-CCCHH Confidence 100 001111234567777888887 46677 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVFPEVT 641 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI~~Ll 641 (747) ++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++... .. ......++++.+. T Consensus 270 ~~~~~~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~ 344 (420) T 4RV1_D 270 VQKEAARALANIASGPDE-----AIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLV 344 (420) T ss_dssp HHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHH T ss_pred HHHHHHHHHHHHHcCCHH-----HHHHHHHCCHHHHHHHHccCCCHHHHHHHHHHHHHHHcChHHHHHHHHHCCHHHHHH Confidence 888899999998875332 1223344578888888888888889999999999998763 22 2333446777788 Q NP_000290.2 642 RLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 642 ~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .++.+ .++.++..++.+|.+++...+.....+.+.++++.+..++.+. ++.++..++.+|..+.... T Consensus 345 ~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~~~ 411 (420) T 4RV1_D 345 KLLTS------TDSEVQKEAARALANIASGPTSAIKAIVDAGGVEVLQKLLTST-DSEVQKEAQRALENIKSGG 411 (420) T ss_dssp HHTTC------SCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHGGGCS-CHHHHHHHHHHHHHHHHTS T ss_pred HHhCC------CCHHHHHHHHHHHHHHHcCChhHHHHHHhccHHHHHHHHcCCC-CHHHHHHHHHHHHhhccCC Confidence 77776 3678899999999999876444444455556788888888766 7789999999999887644 No 101 >4BQK_A IMPORTIN SUBUNIT ALPHA-1A, T-DNA BORDER; TRANSPORT PROTEIN, HYDROLASE, NUCLEAR LOCALIZATION; HET: PEG; 1.997A {ORYZA SATIVA} Probab=97.41 E-value=9.4e-08 Score=96.14 Aligned_cols=158 Identities=18% Similarity=0.251 Sum_probs=116.4 Template_Neff=13.000 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++++.|+.++. +.++.++..++.+|.+++...+. ....+...++++.+..++.+.++.++..++.+|.+++. T Consensus 170 ~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~ 243 (456) T 4BQK_A 170 TRPALPALARLIH-SNDEEVLTDACWALSYLSDGTND-----KIQAVIEAGVCPRLVELLLHPSPSVLIPALRTVGNIVT 243 (456) T ss_dssp HTTHHHHHHHHTT-CCCHHHHHHHHHHHHHHTSSSHH-----HHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCChH-----HHHHHHHCChHHHHHHHHhCCCHHHHHHHHHHHHHHHc Confidence 4456777888887 46778888899999998865332 22333456788889999888888899999999999987 Q NP_000290.2 625 HPL-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAE 702 (747) Q Consensus 625 ~~e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~ 702 (747) ... . ..+...++++.+..++... .++.++..++.+|.+++...+.....+...++++.|..++.+. ++.++. T Consensus 244 ~~~~~~~~~~~~~~~~~l~~~l~~~-----~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~ 317 (456) T 4BQK_A 244 GDDAQTQCIIDHQALPCLLSLLTQN-----LKKSIKKEACWTISNITAGNKDQIQAVINAGIIGPLVNLLQTA-EFDIKK 317 (456) T ss_dssp SCHHHHHHHHTTTHHHHHHHHHHSC-----CCHHHHHHHHHHHHHHHTSCHHHHHHHHHHTCHHHHHHHHHHS-CHHHHH T ss_pred CCHHHHHHHHHCChHHHHHHHHHcC-----CCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhhcC-CHHHHH Confidence 632 2 2334446777888877652 2577889999999999876555555555666788888888766 778888 Q NP_000290.2 703 AARLLLSDMWSS 714 (747) Q Consensus 703 aAL~aLsnL~~~ 714 (747) .++.+|.+++.. T Consensus 318 ~a~~~l~~l~~~ 329 (456) T 4BQK_A 318 EAAWAISNATSG 329 (456) T ss_dssp HHHHHHHHHHHH T ss_pred HHHHHHHHHHcC Confidence 999999988863 No 102 >5TBK_C Importin subunit alpha-3, Regulator of; Nuclear Import, Importin alpha, RCC1; 3.45A {Homo sapiens} Probab=97.41 E-value=1e-07 Score=99.66 Aligned_cols=160 Identities=15% Similarity=0.207 Sum_probs=115.0 Template_Neff=12.200 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) .+.++++.|+.++....+..++..++.+|.+++..... ........++++.+..++.+.++.++..++.+|.+++ T Consensus 196 ~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~ 270 (521) T 5TBK_C 196 ISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDP-----PPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLT 270 (521) T ss_dssp HHTTCHHHHHTTCCTTSCHHHHHHHHHHHHHHHCCCSS-----CCCHHHHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHH T ss_pred HHCCcHHHHHHHhCCCCCHHHHHHHHHHHHHHHcCCCC-----CCCHHHHHHHHHHHHHHhhCCCHHHHHHHHHHHHHHh Confidence 45567788888886323446778899999998865321 1112223567888888888888889999999999998 Q NP_000290.2 624 RH-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAA 701 (747) Q Consensus 624 ~~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr 701 (747) .. ... ..+...++++.+..++.+ .++.++..++.+|.+++...+.....+...++++.+..++.+. ++.++ T Consensus 271 ~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~ 343 (521) T 5TBK_C 271 DAGNEQIQMVIDSGIVPHLVPLLSH------QEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHP-KEKIN 343 (521) T ss_dssp HHCHHHHHHHHHTTCHHHHGGGGGC------SSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCGGGHHHHHTCS-CHHHH T ss_pred ccChHHHHHHHHCChHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHhCCHHHhHHHHhhCC-CHHHH Confidence 76 222 233445677788888765 3677888999999999876444444555557788888888766 78889 Q NP_000290.2 702 EAARLLLSDMWSSK 715 (747) Q Consensus 702 ~aAL~aLsnL~~~~ 715 (747) ..++.+|.+++... T Consensus 344 ~~a~~~l~~l~~~~ 357 (521) T 5TBK_C 344 KEAVWFLSNITAGN 357 (521) T ss_dssp HHHHHHHHHHTTSC T ss_pred HHHHHHHHHHhCCC Confidence 99999999988653 No 103 >5TBK_D Importin subunit alpha-3, Regulator of; Nuclear Import, Importin alpha, RCC1; 3.45A {Homo sapiens} Probab=97.41 E-value=1e-07 Score=99.66 Aligned_cols=160 Identities=15% Similarity=0.207 Sum_probs=115.0 Template_Neff=12.200 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) .+.++++.|+.++....+..++..++.+|.+++..... ........++++.+..++.+.++.++..++.+|.+++ T Consensus 196 ~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~ 270 (521) T 5TBK_D 196 ISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDP-----PPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLT 270 (521) T ss_dssp HHTCCHHHHHTTCCTTSCHHHHHHHHHHHHHHHCCCSS-----CCCHHHHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHH T ss_pred HHCCcHHHHHHHhCCCCCHHHHHHHHHHHHHHHcCCCC-----CCCHHHHHHHHHHHHHHhhCCCHHHHHHHHHHHHHHh Confidence 45567788888886323446778899999998865321 1112223567888888888888889999999999998 Q NP_000290.2 624 RH-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAA 701 (747) Q Consensus 624 ~~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr 701 (747) .. ... ..+...++++.+..++.+ .++.++..++.+|.+++...+.....+...++++.+..++.+. ++.++ T Consensus 271 ~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~ 343 (521) T 5TBK_D 271 DAGNEQIQMVIDSGIVPHLVPLLSH------QEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHP-KEKIN 343 (521) T ss_dssp HHCHHHHHHHHHTTCHHHHGGGGGC------SSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCGGGHHHHHHCS-CHHHH T ss_pred ccChHHHHHHHHCChHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHhCCHHHhHHHHhhCC-CHHHH Confidence 76 222 233445677788888765 3677888999999999876444444555557788888888766 78889 Q NP_000290.2 702 EAARLLLSDMWSSK 715 (747) Q Consensus 702 ~aAL~aLsnL~~~~ 715 (747) ..++.+|.+++... T Consensus 344 ~~a~~~l~~l~~~~ 357 (521) T 5TBK_D 344 KEAVWFLSNITAGN 357 (521) T ss_dssp HHHHHHHHHHTTSC T ss_pred HHHHHHHHHHhCCC Confidence 99999999988653 No 104 >4U2X_F eVP24, KPNA5C; eVP24, importin alpha6, immune antagonist; 3.153A {Zaire ebolavirus} Probab=97.37 E-value=1.2e-07 Score=83.04 Aligned_cols=116 Identities=17% Similarity=0.149 Sum_probs=79.8 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFR-STTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~-~~~~~~~ 324 (747) +++.+..++.+.++.++..+++++.++..........+...++++.+..++.+.++.++..++.++..++.. ....... T Consensus 9 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 88 (175) T 4U2X_F 9 ALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRY 88 (175) T ss_dssp CSHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHH T ss_pred hHHHHHHHHhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCChHHHHHHHHHhCCHHHHHHHHHHHHHHhcCCCHHHHHH Confidence 445566666666778889999999998865443333444446777888877776778888899999988753 2222233 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~ 362 (747) +...+.++.+...+. ..++.++..++.++.+++.... T Consensus 89 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~ 125 (175) T 4U2X_F 89 LVALGCIKPLCDLLT-VMDSKIVQVALNGLENILRLGE 125 (175) T ss_dssp HHHHTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHHHHH T ss_pred HHHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcch Confidence 333456777777776 5566788888888888877543 No 105 >4V3Q_A YIII_M4_AII; DE NOVO PROTEIN, PROTEIN ENGINEERING; HET: GOL, CA; 1.8A {SYNTHETIC CONSTRUCT} Probab=97.37 E-value=1.2e-07 Score=87.00 Aligned_cols=113 Identities=25% Similarity=0.271 Sum_probs=78.0 Template_Neff=12.900 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETR 326 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll 326 (747) ++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.+.+..++..++.++..++...+.....+. T Consensus 10 ~~~~~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~ 89 (247) T 4V3Q_A 10 LPQMVQQLNSPDQQELQSALRKLSQIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAVI 89 (247) T ss_dssp HHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHH T ss_pred HHHHHHHhcCCCHHHHHHHHHHHHHHHcCChhhhhhhhccCcHHHHHHHhcCCCHHHHHHHHHHHHHHHcCcHHHHHHHH Confidence 34455566677788888899999888765444444444556778888888777778888999999988765443333333 Q NP_000290.2 327 RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 327 ~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ..++++.+...+. +.++.++..++.++..++.. T Consensus 90 ~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 122 (247) T 4V3Q_A 90 DAGALPALVQLLS-SPNEQILQEALWTLGNIASG 122 (247) T ss_dssp HTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTS T ss_pred HCCcHHHHHHHhc-CCCHHHHHHHHHHHHHHHcC Confidence 4456777777776 45667777788888777753 No 106 >3NMZ_A APC variant protein, Rho guanine; protein-protein complex, armadillo repeats, CELL; 3.01A {Homo sapiens} Probab=97.34 E-value=1.5e-07 Score=97.01 Aligned_cols=136 Identities=21% Similarity=0.259 Sum_probs=84.7 Template_Neff=12.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDE-SAKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~-~~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .+++.+..++...++.++..++.+|.+++.... .....+...++++.+..++. ..+..++..++.++.+++....... T Consensus 243 ~~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~ 322 (458) T 3NMZ_A 243 GCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENK 322 (458) T ss_pred CcHHHHHHHhcCCCHHHHHHHHHHHHHHHCCCChhHHHHHHHCCHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCchhH Confidence 456667777777777888999999999887543 22334444567777888777 5567788889999999886433333 Q NP_000290.2 323 LETRR-QNGIREAVSLLRR---TGNAEIQKQLTGLLWNLSS----TDELKEELIA-DALPVLADRVI 380 (747) Q Consensus 323 ~~ll~-~~IL~~Ll~lL~s---s~d~eVr~~AL~aLsnLas----~~~~~~~Lve-giLe~Lv~LL~ 380 (747) ..+.. .+.++.+..++.. ..+..++..++.++.+++. .......+.+ ++++.|+.++. T Consensus 323 ~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~l~~~~~~~~l~~~l~ 389 (458) T 3NMZ_A 323 ADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLK 389 (458) T ss_pred HHHHHhcChHHHHHHHHcCCCCCCCHHHHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhC Confidence 33333 4566666666641 1234566677777766652 2222222333 56666666654 No 107 >3L6X_A Catenin delta-1, E-cadherin; p120, catenin, cadherin, E-cadherin, armadillo; HET: SO4; 2.4A {Homo sapiens} Probab=97.34 E-value=1.6e-07 Score=102.08 Aligned_cols=377 Identities=16% Similarity=0.154 Sum_probs=185.5 Template_Neff=11.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQ-DESAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~-~~~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) +++.|+.++.+.+..++..++.+|.+++.. .......+...+.++.++.++.. .+..++..++.+|.+++.... ... T Consensus 91 ~i~~Lv~lL~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~i~~L~~ll~~~~~~~v~~~a~~~L~~L~~~~~-~~~ 169 (584) T 3L6X_A 91 GIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDS-IKM 169 (584) T ss_dssp HHHHHHHGGGCSSHHHHHHHHHHHHHHTSSSCHHHHHHHHHTTHHHHHHHHHHHCCSHHHHHHHHHHHHHHTTSGG-GHH T ss_pred cHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCCHHHHHHHHcCChHHHHHHHHHHcCCHHHHHHHHHHHHHHhcCHH-HHH Confidence 466677777777788999999999999874 34444445556778888888875 366788888999988875432 222 Q NP_000290.2 324 ETRRQNGIREAVSLLR-----------------RTGNAEIQKQLTGLLWNLSSTDE-LKEELIA--DALPVLADRVIIPF 383 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~-----------------ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve--giLe~Lv~LL~~~~ 383 (747) .+... .+..+...+. ...+..++..++.+|.+++.... ....+.. ++++.|+.+|.... T Consensus 170 ~l~~~-~l~~L~~~l~~~~~~~~~~~~~~~~~~~~~~~~v~~~a~~~L~~l~~~~~~~~~~l~~~~g~v~~L~~~l~~~~ 248 (584) T 3L6X_A 170 EIVDH-ALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEI 248 (584) T ss_dssp HHHHH-THHHCCCCCCHHHHCCC----------CCCCHHHHHHHHHHHHHHTSSCHHHHHHHHHSTTHHHHHHHHHHHHH T ss_pred HHHHH-HHHHHHHhccccCCCCCCCCCcCCCCcccChHHHHHHHHHHHHHHhcCCHHHHHHHHhCCCHHHHHHHHHHHHh Confidence 22222 4444444431 12235677888899998887542 3333333 67788888876432 Q NP_000290.2 384 SGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMR--E------LLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLM 455 (747) Q Consensus 384 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 455 (747) .. ...++++.-++..+|+.-..-. + .....+.-....+ .....++..+. -.+.++.|. T Consensus 249 ~~----------~~~~~~~~~~a~~~L~~L~~~~~~~~~~~~~~~~~~~~~~~~~~---~~~~~~~~~l~-~~~~~~~l~ 314 (584) T 3L6X_A 249 GQ----------KDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTG---TSPARGYELLF-QPEVVRIYI 314 (584) T ss_dssp HT----------TCCSCHHHHHHHHHHHHHHTTHHHHSTTCCC-----------------CCCCGGGGGG-SHHHHHHHH T ss_pred cC----------CCCChHHHHHHHHHHHHHHhhhhccChhHHHHHHhcCcCCCCCC---CCChhhhhHhh-ChhHHHHHH Confidence 10 0123334444444443211100 0 0000000000000 00111122221 134555555 Q NP_000290.2 456 AYVQNCVAASRCDDKSVENCMCVLHNLSYRLD---AEVPTRYRQLEYNAR----------NAYTEKSSTGCFSNKSDKMM 522 (747) Q Consensus 456 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~---~~~~~~~~~~~~~~~----------~~~~~~~~~~~~~~~~~~~~ 522 (747) ..+... -+..-.+.+..+|.||+..-. .++....+ +...- +.........+..|-+. T Consensus 315 ~ll~~~-----~~~~~~~~a~~~L~~L~~~~~~~~~~~~~~~~--~~~~l~~L~~ll~~~~~~v~~~a~~~L~~L~~--- 384 (584) T 3L6X_A 315 SLLKES-----KTPAILEASAGAIQNLCAGRWTYGRYIRSALR--QEKALSAIADLLTNEHERVVKAASGALRNLAV--- 384 (584) T ss_dssp HHHHHC-----CCHHHHHHHHHHHHHHHSSCSHHHHHHHHHHT--SHHHHHHHHHGGGCSCHHHHHHHHHHHHHHHT--- T ss_pred HHHHcC-----CCHHHHHHHHHHHHHHhCCCccCCHHHHHHHH--HcChHHHHHHHhcCCCHHHHHHHHHHHHHHhc--- Confidence 554431 144556777888888876321 11111000 00000 00001111111111100 Q NP_000290.2 523 NNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSK--------KDATLEACAGALQNLTASKGLMSSGMSQLIGLKE 594 (747) Q Consensus 523 ~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~--------d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~ 594 (747) +...... +..++++.|+.+|.. . +..++..++.+|.+++..... ....+.+. T Consensus 385 -------------~~~~~~~-l~~~~l~~L~~~L~~-~~~~~~~~~~~~~~~~~l~~L~~l~~~~~~-----~~~~l~~~ 444 (584) T 3L6X_A 385 -------------DARNKEL-IGKHAIPNLVKNLPG-GQQNSSWNFSEDTVISILNTINEVIAENLE-----AAKKLRET 444 (584) T ss_dssp -------------TCSCHHH-HHHHHHHHHHHTSSS-SSCSGGGTCCHHHHHHHHHHHHHHHTTCHH-----HHHHHHHT T ss_pred -------------ChHHHHH-HHcchHHHHHHcCCC-CCCCCCcCCCHHHHHHHHHHHHHHHhcCHH-----HHHHHHHC Confidence 0011111 224788888888863 3 334467888888888764332 23444577 Q NP_000290.2 595 KGLPQIARLLQSG--NSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPE-VTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 595 giI~~Ll~LL~s~--d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~-Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) ++++.|+.++... +..++..|+.+|.+++..... ..+...++++. +..++... ..++.++..++.+|.++.. T Consensus 445 ~~l~~L~~ll~~~~~~~~v~~~a~~~L~~l~~~~~~~~~l~~~g~~~~~l~~~~~~~----~~~~~~~~~a~~~L~~l~~ 520 (584) T 3L6X_A 445 QGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNA----SRSQSSHSYDDSTLPLIDR 520 (584) T ss_dssp THHHHHHHHHTCSSSCHHHHHHHHHHHHHHHTSHHHHHHHHTTTCCGGGGCCC--------------------------- T ss_pred CHHHHHHHHHhcCCCCHHHHHHHHHHHHHHhCCHHHHHHHHHcCCchhhceeccccc----ccCCCCCCcccccccccCC Confidence 8999999998753 477899999999999876444 33445566676 55553211 0357788889999999987 Q NP_000290.2 671 SQ 672 (747) Q Consensus 671 ~s 672 (747) .. T Consensus 521 ~~ 522 (584) T 3L6X_A 521 NQ 522 (584) T ss_dssp -- T ss_pred CC Confidence 53 No 108 >5MFI_B YIII(Dq.V2)4CqI, (KR)4; Designed armadillo repeat protein, peptide; 1.45A {synthetic construct} Probab=97.33 E-value=1.5e-07 Score=85.77 Aligned_cols=113 Identities=20% Similarity=0.252 Sum_probs=78.4 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.+.+..++..++.++.+++.........+ T Consensus 5 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 84 (243) T 5MFI_B 5 ELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKL 84 (243) T ss_dssp CHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHTTTSSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred cHHHHHHHHcCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666777888899999998876544443444445677888888877778888899999998886444333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ...++++.+...+. ..++.++..++.++..++. T Consensus 85 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~ 117 (243) T 5MFI_B 85 IEAGALSPLVKLLD-DASEEVIQEAVWAIANIAS 117 (243) T ss_dssp HHTTCHHHHHHHTS-SSCHHHHHHHHHHHHHHTT T ss_pred HHcCcHHHHHHHHh-cCCHHHHHHHHHHHHHHHc Confidence 33456777777775 4566677777888877775 No 109 >5MFJ_B YIII(Dq.V2)4CqI, (KR)5; Designed armadillo repeat protein, peptide; 1.53A {synthetic construct} Probab=97.33 E-value=1.5e-07 Score=85.77 Aligned_cols=113 Identities=20% Similarity=0.252 Sum_probs=77.5 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.+.+..++..++.++.+++.........+ T Consensus 5 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 84 (243) T 5MFJ_B 5 ELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKL 84 (243) T ss_dssp CHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHGGGCSCTTTC-CHHHHHHHHTTSCHHHHHHH T ss_pred cHHHHHHHHcCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666777888899999998876544443444445677888888877778888899999998886444333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ...++++.+...+. ..++.++..++.++..++. T Consensus 85 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~ 117 (243) T 5MFJ_B 85 IEAGALSPLVKLLD-DASEEVIQEAVWAIANIAS 117 (243) T ss_dssp HHTTCHHHHHHHHH-HSCHHHHHHHHHHHHHHHT T ss_pred HHcCcHHHHHHHHh-cCCHHHHHHHHHHHHHHHc Confidence 33456777777775 4566677777888877775 No 110 >5VOZ_P V-type proton ATPase catalytic subunit; V-ATPase, SidK, rotational state 3;{Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=97.30 E-value=2.1e-07 Score=101.03 Aligned_cols=134 Identities=14% Similarity=0.103 Sum_probs=89.5 Template_Neff=8.900 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICK--LVDLLRS-PNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~--Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .++.++.++.+ +..++..++.+|..++... .........+.++. ++.++.. .+..++..++.+|..++... ... T Consensus 124 ~~~~li~lL~~-d~~i~~~a~~~L~~L~~~~-~~~~~~~~~~~l~~~~li~~L~~~~~~~~~~~a~~~L~~L~~~~-~~r 200 (478) T 5VOZ_P 124 LEQLFDVSLKG-DFQTVLISGFNVVSLLVQN-GLHNVKLVEKLLKNNNLINILQNIEQMDTCYVCIRLLQELAVIP-EYR 200 (478) T ss_dssp HHHHTTSTTSS-CHHHHHHHHHHHHHHHTSS-SCCCHHHHHHHHSSHHHHHHHHCSSCHHHHHHHHHHHHHHTTSH-HHH T ss_pred HHHHHHHHcCC-CHHHHHHHHHHHHHHHHhc-cccCcccchhhcccchHHHHHhccCCccHHHHHHHHHHHHcCCh-HHH Confidence 45666667766 6677888888888887643 22112223456666 7777753 35667888899999888643 333 Q NP_000290.2 323 LETRR--QNGIREAVSLLRRT----------------GNAEIQKQLTGLLWNLSSTDELKEELIA---DALPVLADRVII 381 (747) Q Consensus 323 ~~ll~--~~IL~~Ll~lL~ss----------------~d~eVr~~AL~aLsnLas~~~~~~~Lve---giLe~Lv~LL~~ 381 (747) ..+.. .+.++.|+.++... .++.++..++.++..|+........+.. ++++.|+++++. T Consensus 201 ~~~~~~~~g~i~~Lv~lL~~~~~~~~~~~~~~~~~~~~~~ql~~~a~~~L~~Ls~~~~~~~~l~~~~~~~i~~Lv~ll~~ 280 (478) T 5VOZ_P 201 DVIWLHEKKFMPTLFKILQRATDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTFNPVFANELVQKYLSDFLDLLKLVKI 280 (478) T ss_dssp HHHHHSTTSSHHHHHHHHHHHHHSCSSCCCTTTSSSHHHHHHHHHHHHHHHHHTTSHHHHHHHHHHSHHHHGGGHHHHHH T ss_pred HHHHHccccchHHHHHHHHhccccccccccccccCcCcCHHHHHHHHHHHHHHhcCHHHHHHHHHHhHHHHHHHHHHHhc Confidence 33444 35777888877621 2567888899999999876555555543 688889998886 Q NP_000290.2 382 P 382 (747) Q Consensus 382 ~ 382 (747) . T Consensus 281 ~ 281 (478) T 5VOZ_P 281 T 281 (478) T ss_dssp C T ss_pred c Confidence 4 No 111 >5D80_H V-type proton ATPase catalytic subunit; Hydrolase, Autoinhibition; 6.202A {Saccharomyces cerevisiae} Probab=97.30 E-value=2.1e-07 Score=101.03 Aligned_cols=134 Identities=14% Similarity=0.103 Sum_probs=89.5 Template_Neff=8.900 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICK--LVDLLRS-PNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~--Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .++.++.++.+ +..++..++.+|..++... .........+.++. ++.++.. .+..++..++.+|..++... ... T Consensus 124 ~~~~li~lL~~-d~~i~~~a~~~L~~L~~~~-~~~~~~~~~~~l~~~~li~~L~~~~~~~~~~~a~~~L~~L~~~~-~~r 200 (478) T 5D80_H 124 LEQLFDVSLKG-DFQTVLISGFNVVSLLVQN-GLHNVKLVEKLLKNNNLINILQNIEQMDTCYVCIRLLQELAVIP-EYR 200 (478) T ss_pred HHHHHHHHcCC-CHHHHHHHHHHHHHHHHhc-cccCcccchhhcccchHHHHHhccCCccHHHHHHHHHHHHcCCh-HHH Confidence 45666667766 6677888888888887643 22112223456666 7777753 35667888899999888643 333 Q NP_000290.2 323 LETRR--QNGIREAVSLLRRT----------------GNAEIQKQLTGLLWNLSSTDELKEELIA---DALPVLADRVII 381 (747) Q Consensus 323 ~~ll~--~~IL~~Ll~lL~ss----------------~d~eVr~~AL~aLsnLas~~~~~~~Lve---giLe~Lv~LL~~ 381 (747) ..+.. .+.++.|+.++... .++.++..++.++..|+........+.. ++++.|+++++. T Consensus 201 ~~~~~~~~g~i~~Lv~lL~~~~~~~~~~~~~~~~~~~~~~ql~~~a~~~L~~Ls~~~~~~~~l~~~~~~~i~~Lv~ll~~ 280 (478) T 5D80_H 201 DVIWLHEKKFMPTLFKILQRATDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTFNPVFANELVQKYLSDFLDLLKLVKI 280 (478) T ss_pred HHHHHccccchHHHHHHHHhccccccccccccccCcCcCHHHHHHHHHHHHHHhcCHHHHHHHHHHhHHHHHHHHHHHhc Confidence 33444 35777888877621 2567888899999999876555555543 688889998886 Q NP_000290.2 382 P 382 (747) Q Consensus 382 ~ 382 (747) . T Consensus 281 ~ 281 (478) T 5D80_H 281 T 281 (478) T ss_pred c Confidence 4 No 112 >1JDH_A BETA-CATENIN, hTcf-4; BETA-CATENIN, TCF4, PROTEIN-PROTEIN COMPLEX, TRANSCRIPTION; 1.9A {Homo sapiens} SCOP: a.118.1.1 Probab=97.29 E-value=1.9e-07 Score=95.60 Aligned_cols=138 Identities=25% Similarity=0.275 Sum_probs=87.6 Template_Neff=13.100 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLR--SPNQNVQQAAAGALRNLVFRSTTN- 321 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~--s~d~eVr~~AL~aLs~La~~~~~~- 321 (747) .+++.+...+.+.+..++..++.++..++.........+...+.++.+...+. ..++.++..++.++..++...... T Consensus 266 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~~~~ 345 (529) T 1JDH_A 266 GLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAE 345 (529) T ss_dssp HHHHHHHHHTTCSCHHHHHHHHHHHHHHTTTCHHHHHHHHHTTHHHHHHHHHHHHTTCHHHHHHHHHHHHHHTSSSTTHH T ss_pred hHHHHHHHHhCCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHcCHHHHHHHHHHhcCCChHhHHHHHHHHHHHhcCcccHH Confidence 44555666666667778888888888887654433333344556666766554 345677888888888887654321 Q NP_000290.2 322 --KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVIIP 382 (747) Q Consensus 322 --~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~~ 382 (747) .......+.++.+...+....++.++..++.++.+++........+.. ++++.|..++... T Consensus 346 ~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~l~~~l~~~ 409 (529) T 1JDH_A 346 MAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRA 409 (529) T ss_dssp HHHHHHHHTTCHHHHHHTTSTTCCHHHHHHHHHHHHHHTTSGGGHHHHHHTTHHHHHHHHHHHH T ss_pred HHHHHHHhcccHHHHHHHHCCCCCHHHHHHHHHHHHHHhcChhhhHHHHhcCHHHHHHHHHHhc Confidence 112222356667777775223567888899999988876444444444 6777777777643 No 113 >2Z6G_A B-catenin; Full-Length, Beta-Catenin, CELL ADHESION; 3.4A {Danio rerio} Probab=97.28 E-value=2.2e-07 Score=105.08 Aligned_cols=353 Identities=20% Similarity=0.229 Sum_probs=182.2 Template_Neff=10.700 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP-NQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~-d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .+++.+..++.+.+..++..++.+|..++.........+...+++..++.++... +..++..++.+|..+..... ... T Consensus 276 ~~~~~L~~lL~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~L~~~l~~~~~~~v~~~a~~~L~~l~~~~~-~~~ 354 (780) T 2Z6G_A 276 GGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSS-NKP 354 (780) T ss_pred CHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHhCCCCCHHHHHHHHHHHHHHhCCHH-HHH Confidence 3455566666666778888888888888764443333333445677777777654 56777888888888775432 222 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) .+...++++.+...+. ..+..++..++.+|..++...... ....++++.|+.++... ++++. T Consensus 355 ~~~~~~~l~~L~~~l~-~~~~~v~~~al~~L~~l~~~~~~~-~~~~~~l~~L~~~l~~~----------------~~~v~ 416 (780) T 2Z6G_A 355 AIVEAGGMQALGLHLT-DPSQRLVQNCLWTLRNLSDAATKQ-EGMEGLLGTLVQLLGSD----------------DINVV 416 (780) T ss_pred HHHHCCHHHHHHHHcc-CCCHHHHHHHHHHHHHHhcCCCCH-HHHcChHHHHHHHhcCC----------------CHHHH Confidence 2333456777777776 556778888999998887643321 11125566666666421 23344 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..+|..-..- .+. .+. .-.-.+.++.|...+.. ..-+..-.+.+.+.|.++. T Consensus 417 ~~a~~~L~~l~~~------~~~--------------~~~-~~~~~~~l~~L~~~l~~----~~~~~~v~~~a~~~L~~l~ 471 (780) T 2Z6G_A 417 TCAAGILSNLTCN------NYK--------------NKM-MVCQVGGIEALVRTVLR----AGDREDITEPAICALRHLT 471 (780) T ss_pred HHHHHHHHHHHcC------CHH--------------HHH-HHHHCChHHHHHHHHhc----CCCCHHHHHHHHHHHHHHH Confidence 4444443221100 000 000 00012233333322211 0112233456666666666 Q NP_000290.2 484 YRLDAEV------------PTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRT 551 (747) Q Consensus 484 ~~~~~~~------------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~ 551 (747) .+..... +.-.+-+.. ..+....+....++.+-.. .......+.+.++++. T Consensus 472 ~~~~~~~~~~~~~~~~~~i~~L~~ll~~-~~~~~v~~~a~~~L~~l~~----------------~~~~~~~~~~~~~l~~ 534 (780) T 2Z6G_A 472 SRHQDAEMAQNAVRLHYGLPVVVKLLHP-PSHWPLIKATVGLIRNLAL----------------CPANHAPLREQGAIPR 534 (780) T ss_pred cCCccHHHHHHHHHHCCcHHHHHHHhcC-CCCHHHHHHHHHHHHHHhc----------------CHHHHHHHHhCChHHH Confidence 5442110 000000000 0000000011111111100 0011112345566666 Q NP_000290.2 552 YLNLMGKSKK----------------------DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNS 609 (747) Q Consensus 552 LL~LL~ss~d----------------------~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~ 609 (747) |+.++.. .. ..++..++.+|.+++.... ....+...++++.|+.++.+.++ T Consensus 535 L~~ll~~-~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~a~~aL~~L~~~~~------~~~~~~~~~~l~~L~~~l~~~~~ 607 (780) T 2Z6G_A 535 LVQLLVR-AHQDTQRRTSMGGTQQQFVEGVRMEEIVEACTGALHILARDIH------NRIVIRGLNTIPLFVQLLYSPIE 607 (780) T ss_pred HHHHhcC-CCHHHHHHHHhhhhhhhhhcCCChHHHHHHHHHHHHHHhCChh------HHHHHHhCCcHHHHHHHhcCCCH Confidence 7666652 22 2366777777777775422 12222345667777777777677 Q NP_000290.2 610 DVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 610 eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~ 671 (747) .++..++.+|.+++..... ..+...++++.|..++.+ .++.++..++.+|.+|+.. T Consensus 608 ~v~~~a~~~L~~l~~~~~~~~~~~~~~~i~~L~~ll~~------~~~~v~~~a~~~L~~L~~~ 664 (780) T 2Z6G_A 608 NIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHS------RNEGVATYAAAVLFRMSED 664 (780) T ss_pred HHHHHHHHHHHHHhcCHHHHHHHHHCCcHHHHHHHhcC------CCHHHHHHHHHHHHHHHCC Confidence 7788888888888755332 233345566777777665 3567777788888887764 No 114 >1HO8_A VACUOLAR ATP SYNTHASE SUBUNIT H; HEAT repeat, HYDROLASE; 2.95A {Saccharomyces cerevisiae} SCOP: a.118.1.9 Probab=97.27 E-value=2.5e-07 Score=100.53 Aligned_cols=135 Identities=14% Similarity=0.099 Sum_probs=89.8 Template_Neff=8.900 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICK--LVDLLRS-PNQNVQQAAAGALRNLVFRSTTN 321 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~--Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~ 321 (747) ..++.++.++.+ +..++..++.+|..++... .........+.++. ++.++.. .+..++..++.+|..++... .. T Consensus 125 ~~~~~li~lL~~-d~~i~~~a~~~L~~L~~~~-~~~~~~~~~~~l~~~~lv~~L~~~~~~~~~~~a~~~L~~L~~~~-~~ 201 (480) T 1HO8_A 125 QLEQLFDVSLKG-DFQTVLISGFNVVSLLVQN-GLHNVKLVEKLLKNNNLINILQNIEQMDTCYVCIRLLQELAVIP-EY 201 (480) T ss_dssp HHHHHHHHCSCS-SHHHHHHHHHHHHHHHTST-TTCCHHHHHHHHHCHHHHHHHHCTTCHHHHHHHHHHHHHHHTSH-HH T ss_pred hHHHHHHHHcCC-CHHHHHHHHHHHHHHHHhc-cccCcccchhhcccchHHHHHhcccCccHHHHHHHHHHHHcCCh-HH Confidence 345666777766 6677888888888887643 22112223456776 7777753 35667888899998888643 33 Q NP_000290.2 322 KLETRR--QNGIREAVSLLRRT----------------GNAEIQKQLTGLLWNLSSTDELKEELIA---DALPVLADRVI 380 (747) Q Consensus 322 ~~~ll~--~~IL~~Ll~lL~ss----------------~d~eVr~~AL~aLsnLas~~~~~~~Lve---giLe~Lv~LL~ 380 (747) ...+.. .+.++.|+.++... .++.++..++.++..|.........+.. ++++.|+++++ T Consensus 202 r~~~~~~~~~~i~~Lv~lL~~~~~~~~~~~~~~~~~~~~~~ql~~~a~~~L~~Ls~~~~~~~~i~~~~~~~i~~Lv~ll~ 281 (480) T 1HO8_A 202 RDVIWLHEKKFMPTLFKILQRATDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTFNPVFANELVQKYLSDFLDLLKLVK 281 (480) T ss_dssp HHHHHTTHHHHHHHHHHHHHHHHC-------------CCHHHHHHHHHHHHHHHTTSHHHHHHHHTTSHHHHHHHHHHHH T ss_pred HHHHHHccccchHHHHHHHHhccccchhcchhhccCcCCCHHHHHHHHHHHHHHhcCHHHHHHHHHHhHHHHHHHHHHHh Confidence 333444 35677787777621 2567888899999998876555555543 68888999888 Q NP_000290.2 381 IP 382 (747) Q Consensus 381 ~~ 382 (747) .. T Consensus 282 ~~ 283 (480) T 1HO8_A 282 IT 283 (480) T ss_dssp HC T ss_pred hc Confidence 64 No 115 >6S9O_F designed Armadillo repeat protein with; peptide binder, repeat protein, designed; HET: CA, EDO; 3.17A {synthetic construct} Probab=97.21 E-value=2.9e-07 Score=88.31 Aligned_cols=135 Identities=25% Similarity=0.275 Sum_probs=88.9 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++..+..........+...++++.+...+...++.++..++.++..++.......... T Consensus 173 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 252 (344) T 6S9O_F 173 ALPALVQLLSSPNEQILQLALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 252 (344) T ss_dssp CHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHHcCChHHHHHHHhcChHHHHHHHccCCCHHHHHHHHHHHHHHHcCcHHHHHHH Confidence 45556666666677888889999988876543333333334567777777777777888889999988875544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVII 381 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~~ 381 (747) ...++++.+...+. ..++.++..++.++..++..... ...+.. ++++.|..++.. T Consensus 253 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~ 309 (344) T 6S9O_F 253 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQKQAVKEAGALEKLEQLQSH 309 (344) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGC T ss_pred HHCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCHHHHHHHHhhC Confidence 34456777777776 55677888899999988865322 222222 566666666643 No 116 >1XM9_A plakophilin 1 Plakophilin-1; armadillo repeat, CELL ADHESION; 2.8A {Homo sapiens} SCOP: a.118.1.24 Probab=97.20 E-value=3.2e-07 Score=93.10 Aligned_cols=114 Identities=15% Similarity=0.165 Sum_probs=77.3 Template_Neff=12.600 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP------NQNVQQAAAGALRNLVFRST 319 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~------d~eVr~~AL~aLs~La~~~~ 319 (747) +++.+..++.+.++.++..++.+|.+++... .....+ ...+++.+..++... +..++..++.++.+++...+ T Consensus 332 ~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~-~~~~~~-~~~~~~~l~~~l~~~~~~~~~~~~~~~~a~~~L~~l~~~~~ 409 (457) T 1XM9_A 332 GLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LLHRVM-GNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP 409 (457) T ss_dssp CHHHHHHHTTCSCHHHHHHHHHHHHHHHTSG-GGHHHH-HHHTHHHHHHTTTSCCSCSTTHHHHHHHHHHHHHHHHTTCT T ss_pred hHHHHHHHHhcCCHHHHHHHHHHHHHHhcCH-HHHHHH-HcccHHHHHHHHhcCCCCCCCCHHHHHHHHHHHHHHHhcCH Confidence 4556666676677788889999999988542 222222 234667777777655 57788888999988875444 Q NP_000290.2 320 TNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD 361 (747) Q Consensus 320 ~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~ 361 (747) .....+...+.++.+..++....++.++..++.++..++... T Consensus 410 ~~~~~~~~~~~~~~l~~ll~~~~~~~v~~~a~~~L~~l~~~~ 451 (457) T 1XM9_A 410 QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 451 (457) T ss_dssp HHHHHHCCHHHHHHHHHHHHCTTCHHHHHHHHHHHHTTSSST T ss_pred HHHHHHHhccHHHHHHHHHhCCCCHHHHHHHHHHHHHHhhcH Confidence 444444455677778887762256778888888888887644 No 117 >1XQS_B HSPBP1 protein, Heat shock 70; armadillo repeat, superhelical twist, CHAPERONE; HET: AMP; 2.9A {Homo sapiens} SCOP: a.118.1.21 Probab=97.20 E-value=3.3e-07 Score=87.92 Aligned_cols=134 Identities=22% Similarity=0.180 Sum_probs=90.6 Template_Neff=11.900 Q NP_000290.2 246 TIPKAVQ-YLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP-NQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~-lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~-d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) +++.++. ++.+.+..++..++.++.+++.........+...++++.+..++... +..++..++.++.+++........ T Consensus 66 ~i~~l~~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~ 145 (280) T 1XQS_B 66 GMHLLVGRYLEAGAAGLRWRAAQLIGTCSQNVAAIQEQVLGLGALRKLLRLLDRDACDTVRVKALFAISCLVREQEAGLL 145 (280) T ss_dssp HHHHCCCCCTSCSCHHHHHHHHHHHHHHHTTCHHHHHHHHTTTHHHHHHHHHHSCSCHHHHHHHHHHHHHTTSSCHHHHH T ss_pred cHHHHHHHHhhcCCHHHHHHHHHHHHHHccCCHHHHHHHHHCCHHHHHHHHhccCCCHHHHHHHHHHHHHHHhcCHHHHH Confidence 3455555 66666677888899999998865444344444456777788877765 677888899999998865443333 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) .+...+.++.+..++. ..+..++..++.++.+++.... ....+.. ++++.|+.++. T Consensus 146 ~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 203 (280) T 1XQS_B 146 QFLRLDGFSVLMRAMQ-QQVQKLKVKSAFLLQNLLVGHPEHKGTLCSMGMVQQLVALVR 203 (280) T ss_dssp HHHTTTHHHHHHHHHT-SSCHHHHHHHHHHHHHHHHHCGGGHHHHHTTTHHHHHHHHHT T ss_pred HHHHCCHHHHHHHHhh-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHhCCHHHHHHHHHc Confidence 3444466777777776 4566788889999998887543 3333333 67777777764 No 118 >5MFI_B YIII(Dq.V2)4CqI, (KR)4; Designed armadillo repeat protein, peptide; 1.45A {synthetic construct} Probab=97.18 E-value=3.4e-07 Score=83.37 Aligned_cols=134 Identities=19% Similarity=0.243 Sum_probs=88.0 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++.+++...+.....+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 47 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 126 (243) T 5MFI_B 47 ALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKL 126 (243) T ss_dssp CHHHHHHTTTSSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHHTSSSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCcHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45566666766777888889999998886544433334445677778888877777888889999998876444333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 127 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 182 (243) T 5MFI_B 127 IEAGALSPLVKLLD-DASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLD 182 (243) T ss_dssp HHTTCHHHHHHTTT-SSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHGGG T ss_pred HHCCcHHHHHHHcc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHcc Confidence 44456777777776 5566778888888888876322 2222222 45666665554 No 119 >5MFJ_B YIII(Dq.V2)4CqI, (KR)5; Designed armadillo repeat protein, peptide; 1.53A {synthetic construct} Probab=97.18 E-value=3.4e-07 Score=83.37 Aligned_cols=134 Identities=19% Similarity=0.243 Sum_probs=87.2 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++.+++...+.....+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 47 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 126 (243) T 5MFJ_B 47 ALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKL 126 (243) T ss_dssp CHHHHHHGGGCSCTTTC-CHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCcHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45566666766777888889999998886544433334445677778888877777888889999998876444333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 127 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 182 (243) T 5MFJ_B 127 IEAGALSPLVKLLD-DASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLD 182 (243) T ss_dssp HHTTCHHHHHHTTT-SSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHGGG T ss_pred HHCCcHHHHHHHcc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHcc Confidence 44456777777776 5566778888888888876322 2222222 45666665554 No 120 >6SA6_A DARPin-Armadillo fusion A5; protein fusion, DARPin, Armadillo, shared; HET: EDO; 1.6A {synthetic construct} Probab=97.16 E-value=3.9e-07 Score=91.03 Aligned_cols=134 Identities=25% Similarity=0.292 Sum_probs=90.1 Template_Neff=12.400 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++.........+...++++.+..++...++.++..++.++.+++.........+ T Consensus 200 ~i~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 279 (397) T 6SA6_A 200 ALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAV 279 (397) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred cHHHHHHHcCCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCcHHHHHHH Confidence 45566667776777888899999999887544444444455678888888887788889999999999876443333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++.+++..... ...+.. ++++.|+.++. T Consensus 280 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 335 (397) T 6SA6_A 280 IDAGALPALVQLLS-SPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLS 335 (397) T ss_dssp HHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HhCChHHHHHHHhc-CCcHHHHHHHHHHHHHHhcCcHHHHHHHHhcChHHHHHHHhc Confidence 34456777777776 45667778888888888654322 222222 56666666654 No 121 >6SA8_A ring-like DARPin-Armadillo fusion H83_D01, LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG; protein fusion, DARPin, Armadillo, shared; 2.4A {synthetic construct} Probab=97.16 E-value=4e-07 Score=98.84 Aligned_cols=135 Identities=26% Similarity=0.299 Sum_probs=93.7 Template_Neff=11.900 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++.+++...+.....+...+.++.+...+.+.+..++..++.++..++......... T Consensus 220 ~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 299 (671) T 6SA8_A 220 GALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQA 299 (671) T ss_dssp THHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred ChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHHHHHHcCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCcHHHHH Confidence 34566667777777888999999999987654443334444567788888887777888899999999888654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELK-EELIA-DALPVLADRVI 380 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~-~~Lve-giLe~Lv~LL~ 380 (747) +...++++.+...+. ..++.++..++.++..++...... ..+.. ++++.|..++. T Consensus 300 ~~~~~~~~~L~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~l~~l~~~l~ 356 (671) T 6SA8_A 300 VIDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLS 356 (671) T ss_dssp HHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHHhChHHHHHHHhc-CCcHHHHHHHHHHHHHHhcCCcHHHHHHHhcChHHHHHHHhc Confidence 444567778888886 556788889999999987643322 22333 66777777775 No 122 >1XQR_A HspBP1 protein; armadillo repeat, superhelical twist, CHAPERONE; HET: MSE; 2.1A {Homo sapiens} SCOP: a.118.1.21 Probab=97.14 E-value=4.4e-07 Score=88.91 Aligned_cols=134 Identities=22% Similarity=0.180 Sum_probs=91.0 Template_Neff=11.300 Q NP_000290.2 246 TIPKAVQ-YLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP-NQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~-lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~-d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) +++.++. ++...++.++..++.+|.+++.........+...++++.+..++... +..++..++.++.+++........ T Consensus 82 ~~~~l~~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~l~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~ 161 (296) T 1XQR_A 82 GMHLLVGRYLEAGAAGLRWRAAQLIGTCSQNVAAIQEQVLGLGALRKLLRLLDRDACDTVRVKALFAISCLVREQEAGLL 161 (296) T ss_dssp HHHHCCCCCTTCSSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHHCSCHHHHHHHHHHHHHHHTTCHHHHH T ss_pred cHHHHHHHHHhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHhCCHHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHH Confidence 3455555 66666677888899999998865443334444456777788777765 677888999999999865443333 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) .+...+.++.+...+. ..+..++..++.++.+++.... ....+.. ++++.|+.++. T Consensus 162 ~~~~~~~i~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~i~~L~~ll~ 219 (296) T 1XQR_A 162 QFLRLDGFSVLMRAMQ-QQVQKLKVKSAFLLQNLLVGHPEHKGTLCSMGMVQQLVALVR 219 (296) T ss_dssp HHHHTTHHHHHHHHHH-SSCHHHHHHHHHHHHHHHHHCGGGHHHHHHTTHHHHHHHHHT T ss_pred HHHHCCHHHHHHHHhh-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHhCCHHHHHHHHHc Confidence 3444456777777776 4567788889999999887543 3333333 67777777764 No 123 >4UAD_A Importin alpha import adaptor, Influenza; importin karyopherin complex NLS, PROTEIN; 2.42A {Homo sapiens} Probab=97.13 E-value=4.5e-07 Score=91.78 Aligned_cols=368 Identities=15% Similarity=0.162 Sum_probs=225.0 Template_Neff=12.900 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDE--SAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTN 321 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~--~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~ 321 (747) .+++.+...+.+.++.++..++.+|..+..... .....+...++++.+...+.. .++.++..++.++..++...... T Consensus 23 ~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~ 102 (479) T 4UAD_A 23 VITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQ 102 (479) T ss_dssp CCCHHHHHHHTSSCHHHHHHHHHHHHHHHTCSSSCCHHHHHHSTTHHHHHHHHTTCTTCHHHHHHHHHHHHHHTTSCHHH T ss_pred hhHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCCCChhHhhcCcchHHHHHHHhhcCCCHHHHHHHHHHHHHHhCCCchH Confidence 456666777777778889999999988876422 111122223567777777765 66778888999998887654333 Q NP_000290.2 322 KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVD 399 (747) Q Consensus 322 ~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~ 399 (747) ...+...++++.+..++. ..++.++..++.++..++.... ....+.. ++++.|+.++... .+ T Consensus 103 ~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~---------------~~ 166 (479) T 4UAD_A 103 TKIVIEAGAVPIFIELLN-SDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKS---------------TR 166 (479) T ss_dssp HHHHHHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHHHHC---------------CC T ss_pred HHHHHHcCHHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCChHHHHHHHhCCcHHHHHHHhhcC---------------Cc Confidence 333333457777788776 5567888899999998887533 2223333 5666666666521 12 Q NP_000290.2 400 PEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVL 479 (747) Q Consensus 400 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 479 (747) +++-..+..+|..-.. ............+.++.|...+.. -+..-...+...| T Consensus 167 ~~~~~~a~~~l~~l~~---------------------~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l 219 (479) T 4UAD_A 167 LTMTRNAVWALSNLCR---------------------GKNPPPEFAKVSPCLPVLSRLLFS------SDSDLLADACWAL 219 (479) T ss_dssp HHHHHHHHHHHHHHHC---------------------CCSSCCCGGGTGGGHHHHHHHTTC------CCHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHc---------------------CCCCCchhhcccchHHHHHHHhcC------CCHHHHHHHHHHH Confidence 3333333333321110 000011111122334433333321 1111222233333 Q NP_000290.2 480 HNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKS 559 (747) Q Consensus 480 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss 559 (747) .++.... ......+.+.++++.++.++. + T Consensus 220 ~~l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~ 248 (479) T 4UAD_A 220 SYLSDGP--------------------------------------------------NEKIQAVIDSGVCRRLVELLM-H 248 (479) T ss_dssp HHHTSSS--------------------------------------------------HHHHHHHHHTTCHHHHHHGGG-C T ss_pred HHHhcCc--------------------------------------------------hHHHHHHHhCCHHHHHHHHhc-C Confidence 3322100 000111234567788888887 4 Q NP_000290.2 560 KKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVF 637 (747) Q Consensus 560 ~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI 637 (747) .++.++..++.+|.+++..... ....+...++++.|..++.+.++.++..++.+|.+++... .. ..+...+++ T Consensus 249 ~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~ 323 (479) T 4UAD_A 249 NDYKVASPALRAVGNIVTGDDI-----QTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIF 323 (479) T ss_dssp SCHHHHHHHHHHHHHHTTSCHH-----HHHHHHTTTCHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCH T ss_pred CCHHhHHHHHHHHHHHhcCCHH-----HHHHHHhcChHHHHHHHhhCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHH Confidence 6778888999999998875332 1223334578888999998888889999999999998763 22 233445678 Q NP_000290.2 638 PEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS-QPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 638 ~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~-s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) +.+..++.+ .++.++..++.+|.+++.. .+.....+.+.++++.+..++.+. ++.++..++.+|.+++...+ T Consensus 324 ~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~~~~ 396 (479) T 4UAD_A 324 PVLIEILQK------AEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVM-DSKIVQVALNGLENILRLGE 396 (479) T ss_dssp HHHHHHHHH------SCHHHHHHHHHHHHHHHHHSCHHHHHHHHHTTCHHHHHGGGGCS-CHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHhc------cCHHHHHHHHHHHHHHHcCCCHHHHHHHHHcCcHHHHHHHhhcC-CHHHHHHHHHHHHHHHHHHH Confidence 888888876 3678899999999999864 233444455556788888888866 78889999999999987654 Q NP_000290.2 717 LQ 718 (747) Q Consensus 717 ~~ 718 (747) .. T Consensus 397 ~~ 398 (479) T 4UAD_A 397 QE 398 (479) T ss_dssp HH T ss_pred Hh Confidence 43 No 124 >5MFD_C YIIIM''6AII, Capsid decoration protein,pD_(KR)5; Designed armadillo repeat protein, peptide; HET: CA; 2.3A {synthetic construct} Probab=97.07 E-value=6.1e-07 Score=84.84 Aligned_cols=114 Identities=25% Similarity=0.284 Sum_probs=75.6 Template_Neff=13.300 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.+..++..++.++..+........... T Consensus 89 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 168 (328) T 5MFD_C 89 ALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAV 168 (328) T ss_dssp HHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666677788888999988876543333333344567777777777777888889999988875443332333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..+..++..++.++..++.. T Consensus 169 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 202 (328) T 5MFD_C 169 IDAGALPALVQLLS-SPNEQILQEALWTLGNIASG 202 (328) T ss_dssp HHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHHTS T ss_pred HHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHHHcC Confidence 33456666777775 45566777777777777653 No 125 >6HB3_B Protein HGH1; solenoid protein, Armadillo repeat, CHAPERONE; 3.0A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=97.07 E-value=7e-07 Score=92.28 Aligned_cols=121 Identities=9% Similarity=-0.026 Sum_probs=77.4 Template_Neff=10.100 Q NP_000290.2 246 TIPKAVQYLSS---QDEKYQAIGAYYIQHTCFQDESAKQQVY--QLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTT 320 (747) Q Consensus 246 iL~~Ll~lL~s---sd~eVr~sAL~aLsnLs~~~~~~~~~li--~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~ 320 (747) .++.|+.++.. .+..++..++.+|.++... ......+. ..+.++.++.++...+..++..++.+|.+++.... T Consensus 52 ~i~~Lv~ll~~~~~~~~~~~~~al~~L~~l~~~-~~~~~~l~~~~~g~i~~L~~ll~~~~~~~~~~a~~~L~nl~~~~~- 129 (369) T 6HB3_B 52 PIKDIIKMIMDPEHGTRVIIQQGVTILVNLSED-KLVRNIILSDDKKFLKFLVWKIVDLTNPNADIMCILLSNLAKDDG- 129 (369) T ss_pred cHHHHHHHHhCCCCCCHHHHHHHHHHHHHHcCC-HHHHHHHHhccCCcHHHHHHHhcCCCHHHHHHHHHHHHHHcCChH- Confidence 56667777743 3567888899999998754 33344444 56788888888877667788888999988886432 Q NP_000290.2 321 NKLET-------------------------RRQNGIREAVSLLRRTG------NAEIQKQLTGLLWNLSSTDELKEELIA 369 (747) Q Consensus 321 ~~~~l-------------------------l~~~IL~~Ll~lL~ss~------d~eVr~~AL~aLsnLas~~~~~~~Lve 369 (747) ....+ ...++++.++.++. .. +..++..++.+|.+++........+.+ T Consensus 130 ~~~~l~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~i~~Lv~~l~-~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~l~~ 208 (369) T 6HB3_B 130 ILAVLNIKRNSSGEEVDDGLKLAALNKEVFKSLRAMDCLMDCFV-KGYDKKLTKYASFNYLAFFFADISRFKLGRMYFIE 208 (369) T ss_pred HHHHHHhcCCCCCCHHHHHHHHHHHHHHHHHHCCcHHHHHHHhc-CCCCccCCCHHHHHHHHHHHHHHcCCHHHHHHHHH Confidence 11212 11345666666665 32 345666777777777765444444444 No 126 >3OPB_A SWI5-dependent HO expression protein 4; HEAT and ARM fold, Myosin; 2.9A {Saccharomyces cerevisiae} Probab=97.06 E-value=7.2e-07 Score=100.91 Aligned_cols=156 Identities=12% Similarity=0.164 Sum_probs=96.5 Template_Neff=10.500 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKE------KGLPQIARLLQSGNSDVVRSGASLL 619 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~------giI~~Ll~LL~s~d~eVr~~AL~aL 619 (747) .++++.|+.++. +.+..++..++.+|.+++..... ....+.+. ++++.|+.++.+.++.++..++++| T Consensus 605 ~~~~~~L~~ll~-~~~~~v~~~a~~~L~~L~~~~~~-----~~~~~~~~~~~~~~~~l~~L~~ll~~~~~~v~~~a~~~L 678 (778) T 3OPB_A 605 KVYWSTIENLML-DENVPLQRSTLELISNMMSHPLT-----IAAKFFNLENPQSLRNFNILVKLLQLSDVESQRAVAAIF 678 (778) T ss_dssp HHHHHHHHHGGG-CSSHHHHHHHHHHHHHHHTSGGG-----TGGGTSCCSSHHHHHHHHHHHHGGGCSCHHHHHHHHHHH T ss_pred ccHHHHHHHHhh-CCCHHHHHHHHHHHHHHhcChhH-----HHHHhcCCCChhHHHhHHHHHHHhcCCCHHHHHHHHHHH Confidence 356777777776 35677788888888888864321 12222332 6778888888777778888888888 Q NP_000290.2 620 SNMSRH-PLL-HRVMG-NQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA----K-QYFS-SSMLNNIIN 690 (747) Q Consensus 620 snLa~~-~e~-~~ll~-~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~----~-~Lve-~giL~~Ll~ 690 (747) ++++.. +.. ...+. .++++.|+.++.+.. .+..++..++++|.+++...+... . .+.+ .++++.|.. T Consensus 679 ~~l~~~~~~~~~~l~~~~~~i~~L~~~L~~~~----~~~~l~~~a~~aL~~L~~~~~~~~~~~~~~~l~~~~~~~~~L~~ 754 (778) T 3OPB_A 679 ANIATTIPLIAKELLTKKELIENAIQVFADQI----DDIELRQRLLMLFFGLFEVIPDNGTNEVYPLLQENQKLKDALNM 754 (778) T ss_dssp HHHHHHCHHHHHHHTTCHHHHHHHHHHHHHTT----TCHHHHHHHHHHHHHHHTTCCSTTTTSCCHHHHSCHHHHHHHHH T ss_pred HHHHccCHHHHHHHhcCccHHHHHHHHHHhCC----CCHHHHHHHHHHHHHHHhhCCcCCCccchhHHhcCHHHHHHHHH Confidence 888755 222 23332 567777777776510 145678888888888886533222 0 1222 256777777 Q NP_000290.2 691 LCRSSA-SPKAAEAARLLLSDM 711 (747) Q Consensus 691 LL~s~~-d~eVr~aAL~aLsnL 711 (747) ++.... ++.++..+..+|.++ T Consensus 755 ~l~~~~~~~~~~~~~~~~L~~l 776 (778) T 3OPB_A 755 SLKRGDSGPEFSAAIPVILAKI 776 (778) T ss_dssp HHSSSSSCSSTTSHHHHHHTTC T ss_pred HHhhCCCCHHHHHHHHHHHHhc Confidence 776431 335555566555543 No 127 >4HXT_A De Novo Protein OR329; Structural Genomics, PSI-Biology, Protein Structure; 1.95A {artificial gene} Probab=97.02 E-value=7.7e-07 Score=80.85 Aligned_cols=113 Identities=29% Similarity=0.332 Sum_probs=76.4 Template_Neff=13.200 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETR 326 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll 326 (747) ++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.+..++..++.++..++.........+. T Consensus 4 ~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~ 83 (252) T 4HXT_A 4 VEKLVKLLTSTDSETQKEAARDLAEIASGPASAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIV 83 (252) T ss_dssp HHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHH T ss_pred HHHHHHHcCCCCHHHHHHHHHHHHHHcCCCHHHHHHHHHCCHHHHHHHHhhCCCHHHHHHHHHHHHHHHCCCHHHHHHHH Confidence 44556666667778888999999988765433333334446677777777777778888999999988765433333333 Q NP_000290.2 327 RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 327 ~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ..++++.+...+. ..++.++..++.++.+++.. T Consensus 84 ~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 116 (252) T 4HXT_A 84 DAGGVEVLVKLLT-STDSEVQKEAARALANIASG 116 (252) T ss_dssp HTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHTTS T ss_pred HCChHHHHHHHcc-CCCHHHHHHHHHHHHHHHcC Confidence 3456667777775 45567777777887777653 No 128 >3GQ2_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.18A {Bos taurus} Probab=97.01 E-value=9.1e-07 Score=98.43 Aligned_cols=136 Identities=15% Similarity=0.144 Sum_probs=91.1 Template_Neff=10.100 Q NP_000290.2 245 LTIPKAVQYLSS--QDEKYQAIGAYYIQHTCFQDES-----------------AKQQVY-QLGGICKLVDLLRSPNQNVQ 304 (747) Q Consensus 245 ~iL~~Ll~lL~s--sd~eVr~sAL~aLsnLs~~~~~-----------------~~~~li-~~~IL~~Ll~lL~s~d~eVr 304 (747) .+++.|+..+.. .+..+...++.+|..++..... ....+. ..+.++.++.++...+..++ T Consensus 60 ~~l~~Li~~L~~~~~d~~~~~~al~~L~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~Ll~ll~~~~~~~~ 139 (651) T 3GQ2_A 60 QAMEHLIHVLQTDRSDSEIIGYALDTLYNIISNDEEEEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEEFDFHVR 139 (651) T ss_dssp HHHHHHHHHHTTCTTCHHHHHHHHHHHHHHHCCSSSCC----------CHHHHHHHHHHTSHHHHHTHHHHTTCCCHHHH T ss_pred cHHHHHHHHHhcCCCCHHHHHHHHHHHHHHhCCCChHhhhhcccccchHHHHHHHHHHHhcCchHHHHHHHccCCCHHHH Confidence 456667777764 4567788888888888764332 112222 35667777777777777888 Q NP_000290.2 305 QAAAGALRNLVFRSTTNKL-ETR-RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST-DELKEELIA-DALPVLADRVI 380 (747) Q Consensus 305 ~~AL~aLs~La~~~~~~~~-~ll-~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~-~~~~~~Lve-giLe~Lv~LL~ 380 (747) ..++.+|..++........ .+. ..+.+..++.++. ..+..++..++.+|.+++.. ......+.. ++++.|+.++. T Consensus 140 ~~al~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~-~~~~~i~~~a~~~L~~l~~~~~~~~~~l~~~g~~~~L~~ll~ 218 (651) T 3GQ2_A 140 WPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLA-DSREVIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIIT 218 (651) T ss_dssp HHHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHGGGGG-CSSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHH T ss_pred HHHHHHHHHHHHhccHHHHHHHHhCccHHHHHHHHhc-CCCHHHHHHHHHHHHHHhCCCHHHHHHHHhCChHHHHHHHHH Confidence 9999999988865432211 222 3456778888886 55677888999999999873 333333333 88888888886 Q NP_000290.2 381 I 381 (747) Q Consensus 381 ~ 381 (747) . T Consensus 219 ~ 219 (651) T 3GQ2_A 219 E 219 (651) T ss_dssp H T ss_pred H Confidence 4 No 129 >3GRL_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.0A {Bos taurus} Probab=97.01 E-value=9.1e-07 Score=98.43 Aligned_cols=136 Identities=15% Similarity=0.144 Sum_probs=90.5 Template_Neff=10.100 Q NP_000290.2 245 LTIPKAVQYLSS--QDEKYQAIGAYYIQHTCFQDES-----------------AKQQVY-QLGGICKLVDLLRSPNQNVQ 304 (747) Q Consensus 245 ~iL~~Ll~lL~s--sd~eVr~sAL~aLsnLs~~~~~-----------------~~~~li-~~~IL~~Ll~lL~s~d~eVr 304 (747) .+++.|+..+.. .+..+...++.+|..++..... ....+. ..+.++.++.++...+..++ T Consensus 60 ~~l~~Li~~L~~~~~d~~~~~~al~~L~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~Ll~ll~~~~~~~~ 139 (651) T 3GRL_A 60 QAMEHLIHVLQTDRSDSEIIGYALDTLYNIISNDEEEEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEEFDFHVR 139 (651) T ss_dssp CCHHHHHHHHHSCTTCHHHHHHHHHHHHHHHCCC--------------CHHHHHHHHHHHSTHHHHHHHHHTTCCCHHHH T ss_pred cHHHHHHHHHhcCCCCHHHHHHHHHHHHHHhCCCChHhhhhcccccchHHHHHHHHHHHhcCchHHHHHHHccCCCHHHH Confidence 456667777764 4567788888888888764332 112222 35667777777777777888 Q NP_000290.2 305 QAAAGALRNLVFRSTTNKL-ETR-RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST-DELKEELIA-DALPVLADRVI 380 (747) Q Consensus 305 ~~AL~aLs~La~~~~~~~~-~ll-~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~-~~~~~~Lve-giLe~Lv~LL~ 380 (747) ..++.+|..++........ .+. ..+.+..++.++. ..+..++..++.+|.+++.. ......+.. ++++.|+.++. T Consensus 140 ~~al~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~-~~~~~i~~~a~~~L~~l~~~~~~~~~~l~~~g~~~~L~~ll~ 218 (651) T 3GRL_A 140 WPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLA-DSREVIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIIT 218 (651) T ss_dssp HHHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHHGGGG-CSSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHH T ss_pred HHHHHHHHHHHHhccHHHHHHHHhCccHHHHHHHHhc-CCCHHHHHHHHHHHHHHhCCCHHHHHHHHhCChHHHHHHHHH Confidence 9999999988865432211 222 3456778888886 55677888999999999873 333333333 88888888886 Q NP_000290.2 381 I 381 (747) Q Consensus 381 ~ 381 (747) . T Consensus 219 ~ 219 (651) T 3GRL_A 219 E 219 (651) T ss_dssp H T ss_pred H Confidence 4 No 130 >4HXT_A De Novo Protein OR329; Structural Genomics, PSI-Biology, Protein Structure; 1.95A {artificial gene} Probab=97.01 E-value=8.1e-07 Score=80.69 Aligned_cols=114 Identities=27% Similarity=0.320 Sum_probs=76.2 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++.........+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 45 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 124 (252) T 4HXT_A 45 GVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAI 124 (252) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHhhCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCChHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666677888889999998876544333333444667777777777777888889999988876443332233 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++..++.. T Consensus 125 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 158 (252) T 4HXT_A 125 VDAGGVEVLVKLLT-STDSEVQKEAARALANIASG 158 (252) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTS T ss_pred HHCCHHHHHHHHhh-CCCHHHHHHHHHHHHHHHcC Confidence 33356666666665 45567777788888877764 No 131 >4PLS_B Arm00010; PEPTIDE BINDING PROTEIN, designed armadillo; HET: CA; 2.35A {synthetic construct} Probab=97.00 E-value=8.3e-07 Score=82.05 Aligned_cols=114 Identities=25% Similarity=0.284 Sum_probs=75.7 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.++.++..++.++..++.........+ T Consensus 44 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 123 (281) T 4PLS_B 44 ALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAV 123 (281) T ss_dssp HHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCHHHHHHHHhCCcHHHHHHHcCCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 45566666666777888889999998876443333333444577777777777777888888898888876433332333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++..++.. T Consensus 124 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 157 (281) T 4PLS_B 124 IDAGALPALVQLLS-SPNEQILQEALWTLGNIASG 157 (281) T ss_dssp HHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHTTS T ss_pred HHCCHHHHHHHHcc-CCCHHHHHHHHHHHHHHHcC Confidence 33456666777665 44566777777777776653 No 132 >5IZA_A Adenomatous polyposis coli protein, ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2; APC, ASEF, Colon CANCER, Drug; 1.5A {Homo sapiens} Probab=96.99 E-value=9.5e-07 Score=87.41 Aligned_cols=114 Identities=22% Similarity=0.254 Sum_probs=75.1 Template_Neff=12.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQ-DESAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~-~~~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .+++.+..++.+.++.++..++.++.+++.. .......+...++++.+..++.. .+..++..++.+|.+++....... T Consensus 127 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~ 206 (354) T 5IZA_A 127 GCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENK 206 (354) T ss_dssp HHHHHHHHGGGCSCHHHHHHHHHHHHHHHTTCCHHHHHHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHHTTCHHHH T ss_pred hHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCChhHHHHHHHCCHHHHHHHHHHhcCCHHHHHHHHHHHHHHHcCChHhH Confidence 3455666677766778888999999998874 22223334445677778888776 677888889999999886533333 Q NP_000290.2 323 LETRR-QNGIREAVSLLRR---TGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 323 ~~ll~-~~IL~~Ll~lL~s---s~d~eVr~~AL~aLsnLa 358 (747) ..+.. .++++.+..++.. ..+..++..++.++..+. T Consensus 207 ~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~L~~l~ 246 (354) T 5IZA_A 207 ADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVS 246 (354) T ss_dssp HHHHTSTTHHHHHHHHTCSSCSSCCHHHHHHHHHHHHHHH T ss_pred HHHHhhccHHHHHHHHHhhcCCCCcHHHHHHHHHHHHHHH Confidence 33444 4667777777651 112456666777777765 No 133 >5IZ8_A Adenomatous polyposis coli protein, ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2; APC, ASEF, Colon CANCER, Drug; HET: PGE; 3.06A {Homo sapiens} Probab=96.97 E-value=1e-06 Score=87.19 Aligned_cols=113 Identities=22% Similarity=0.270 Sum_probs=74.6 Template_Neff=12.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQ-DESAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~-~~~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) +++.+..++.+.++.++..++.++.+++.. .......+...++++.+..++.. .+..++..++.+|.+++........ T Consensus 128 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~ 207 (354) T 5IZ8_A 128 CMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKA 207 (354) T ss_dssp HHHHHHHGGGSSCHHHHHHHHHHHHHHHTTCCHHHHHHHHHTTHHHHHHHHHHHCCSHHHHHHHHHHHHHHHTSCHHHHH T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCChhHHHHHHHCCHHHHHHHHHHhcCCHHHHHHHHHHHHHHHcCChHhHH Confidence 455666677666778888999999998874 22223334445677778888776 6778888899999998865333333 Q NP_000290.2 324 ETRR-QNGIREAVSLLRR---TGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 324 ~ll~-~~IL~~Ll~lL~s---s~d~eVr~~AL~aLsnLa 358 (747) .+.. .++++.+..++.. ..+..++..++.++..+. T Consensus 208 ~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~L~~l~ 246 (354) T 5IZ8_A 208 DICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVS 246 (354) T ss_dssp HHHTSTTHHHHHHHHTTCCCTTSCCHHHHHHHHHHHHHH T ss_pred HHHhhccHHHHHHHHHhhcCCCCcHHHHHHHHHHHHHHH Confidence 3444 4667777777651 112456666777777765 No 134 >6SA7_B DARPin-Armadillo fusion C8long83; protein fusion, DARPin, Armadillo, shared; 3.3A {synthetic construct} Probab=96.96 E-value=1.1e-06 Score=90.60 Aligned_cols=135 Identities=25% Similarity=0.264 Sum_probs=91.1 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.+|.+++.........+...++++.+..++...++.++..++.+|..++.........+ T Consensus 342 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 421 (510) T 6SA7_B 342 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 421 (510) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHHTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 34445555556667788888888888876544433334445677788888877778888899999998875544433344 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVII 381 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~~ 381 (747) ...++++.+..++. ..++.++..++.++..++.... ....+.. ++++.|..++.. T Consensus 422 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~ 478 (510) T 6SA7_B 422 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQKQAVKEAGALEKLEQLQSH 478 (510) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHGGGC T ss_pred HHcCcHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCCchHHHHHHHCCHHHHHHHHhhc Confidence 44567778888886 5677889999999999985432 2222333 667777776653 No 135 >4V3Q_A YIII_M4_AII; DE NOVO PROTEIN, PROTEIN ENGINEERING; HET: GOL, CA; 1.8A {SYNTHETIC CONSTRUCT} Probab=96.95 E-value=1.1e-06 Score=80.29 Aligned_cols=135 Identities=24% Similarity=0.251 Sum_probs=89.9 Template_Neff=12.900 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.+..++..++.++.+++.........+...++++.+...+.+.+..++..++.++..++......... T Consensus 92 ~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~ 171 (247) T 4V3Q_A 92 GALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQA 171 (247) T ss_dssp THHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred CcHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHH Confidence 34556666666667788888899998887654433333344567777888777777788888999998887654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ....++++.+...+. ..++.++..++.++..++.... ....+.. ++++.|..++. T Consensus 172 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 228 (247) T 4V3Q_A 172 VIDAGALPALVQLLS-SPNEQILQEALWTLGNIASGGNEQKQAVKEAGALEKLEQLQS 228 (247) T ss_dssp HHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCHHHHHHHHHh Confidence 334456777777776 5567788889999998886532 2222333 66677776665 No 136 >5Z8H_A Adenomatous polyposis coli protein, Peptide; APC, inhibitor, PROTEIN BINDING-INHIBITOR complex; HET: PHQ, GOL; 1.79A {Homo sapiens} Probab=96.93 E-value=1.2e-06 Score=84.95 Aligned_cols=134 Identities=21% Similarity=0.263 Sum_probs=83.9 Template_Neff=12.500 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQ-DESAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~-~~~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) .+++.+...+.+.++.++..++.++.+++.. .......+...++++.+..++.. .++.++..++.++.+++....... T Consensus 122 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~ 201 (339) T 5Z8H_A 122 GCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENK 201 (339) T ss_pred ChHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCCHHHHHHHHHCCcHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHH Confidence 3455666667666778888999999998874 22223334445677778887776 577788889999999886444333 Q NP_000290.2 323 LETRR-QNGIREAVSLLRRTGN----AEIQKQLTGLLWNLSS----TDELKEELIA-DALPVLADRV 379 (747) Q Consensus 323 ~~ll~-~~IL~~Ll~lL~ss~d----~eVr~~AL~aLsnLas----~~~~~~~Lve-giLe~Lv~LL 379 (747) ..+.. .++++.+..++. ..+ ..++..++.++.++.. .......+.. ++++.++.++ T Consensus 202 ~~~~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l 267 (339) T 5Z8H_A 202 ADICAVDGALAFLVGTLT-YRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHL 267 (339) T ss_pred HHHHHhcChHHHHHHHhc-CCCCCCCHHHHHHHHHHHHHHHHhhccCHHHHHHHHHCCHHHHHHHHH Confidence 34444 466777777775 222 5667777777777752 2222222222 5555555555 No 137 >5AEI_B DESIGNED ARMADILLO REPEAT PROTEIN YIIIM5AII; DE NOVO PROTEIN, PROTEIN-PEPTIDE COMPLEX; HET: CA, ACT; 1.83A {SYNTHETIC CONSTRUCT} Probab=96.89 E-value=1.4e-06 Score=80.58 Aligned_cols=112 Identities=27% Similarity=0.322 Sum_probs=75.3 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++..++...+.....+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 173 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 252 (286) T 5AEI_B 173 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAV 252 (286) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHccCCCHHHHHHHHHHHHHHhCCCHHHHHHH Confidence 45556666666677788888999988876544333333344567777777777777888889999988885544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++++.+...+. ..++.++..++.++..++ T Consensus 253 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~ 284 (286) T 5AEI_B 253 KEAGALEKLEQLQS-HENEKIQKEAQEALEKLQ 284 (286) T ss_dssp HHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHH T ss_pred HHcCHHHHHHHHhh-CCCHHHHHHHHHHHHHHh Confidence 34456677777776 456677777877777664 No 138 >5IZA_A Adenomatous polyposis coli protein, ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2; APC, ASEF, Colon CANCER, Drug; 1.5A {Homo sapiens} Probab=96.88 E-value=1.5e-06 Score=85.84 Aligned_cols=124 Identities=24% Similarity=0.343 Sum_probs=84.2 Template_Neff=12.000 Q NP_000290.2 258 DEKYQAIGAYYIQHTCFQDESAKQQVYQ-LGGICKLVDLLRSPNQNVQQAAAGALRNLVFR-STTNKLETRRQNGIREAV 335 (747) Q Consensus 258 d~eVr~sAL~aLsnLs~~~~~~~~~li~-~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~-~~~~~~~ll~~~IL~~Ll 335 (747) +..++..++.++.+++.........+.. .++++.+..++...++.++..++.++.+++.. .......+...++++.+. T Consensus 97 ~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~ 176 (354) T 5IZA_A 97 SITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALM 176 (354) T ss_dssp HHHHHHHHHHHHHHHHTTCHHHHHHHHHCHHHHHHHHHGGGCSCHHHHHHHHHHHHHHHTTCCHHHHHHHHHTTHHHHHH T ss_pred CHHHHHHHHHHHHHHhcCCHHHHHHHHccchHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCChhHHHHHHHCCHHHHHH Confidence 5677888888888887644333333333 46777888888777788889999999998864 222233344456777788 Q NP_000290.2 336 SLLRRTGNAEIQKQLTGLLWNLSST-DELKEELIA--DALPVLADRVII 381 (747) Q Consensus 336 ~lL~ss~d~eVr~~AL~aLsnLas~-~~~~~~Lve--giLe~Lv~LL~~ 381 (747) .++....++.++..++.++.+++.. ......+.. ++++.|+.++.. T Consensus 177 ~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~ 225 (354) T 5IZA_A 177 ECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTY 225 (354) T ss_dssp HHHHHCCCHHHHHHHHHHHHHHHTTCHHHHHHHHTSTTHHHHHHHHTCS T ss_pred HHHHhcCCHHHHHHHHHHHHHHHcCChHhHHHHHhhccHHHHHHHHHhh Confidence 8876225677888899999999876 444434433 667777777664 No 139 >5IZ8_A Adenomatous polyposis coli protein, ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2; APC, ASEF, Colon CANCER, Drug; HET: PGE; 3.06A {Homo sapiens} Probab=96.88 E-value=1.6e-06 Score=85.78 Aligned_cols=124 Identities=24% Similarity=0.343 Sum_probs=84.2 Template_Neff=12.000 Q NP_000290.2 258 DEKYQAIGAYYIQHTCFQDESAKQQVYQ-LGGICKLVDLLRSPNQNVQQAAAGALRNLVFR-STTNKLETRRQNGIREAV 335 (747) Q Consensus 258 d~eVr~sAL~aLsnLs~~~~~~~~~li~-~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~-~~~~~~~ll~~~IL~~Ll 335 (747) +..++..++.++.+++.........+.. .++++.+..++...++.++..++.++.+++.. .......+...++++.+. T Consensus 97 ~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~ 176 (354) T 5IZ8_A 97 SITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALM 176 (354) T ss_dssp HHHHHHHHHHHHHHHHTTCHHHHHHHHHCHHHHHHHHHGGGSSCHHHHHHHHHHHHHHHTTCCHHHHHHHHHTTHHHHHH T ss_pred CHHHHHHHHHHHHHHhcCCHHHHHHHHccchHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCChhHHHHHHHCCHHHHHH Confidence 5677888888888887644333333333 46777888888777788888999999998864 222233344456777788 Q NP_000290.2 336 SLLRRTGNAEIQKQLTGLLWNLSST-DELKEELIA--DALPVLADRVII 381 (747) Q Consensus 336 ~lL~ss~d~eVr~~AL~aLsnLas~-~~~~~~Lve--giLe~Lv~LL~~ 381 (747) .++....++.++..++.+|.+++.. ......+.. ++++.|+.++.. T Consensus 177 ~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~ 225 (354) T 5IZ8_A 177 ECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTY 225 (354) T ss_dssp HHHHHCCSHHHHHHHHHHHHHHHTSCHHHHHHHHTSTTHHHHHHHHTTC T ss_pred HHHHhcCCHHHHHHHHHHHHHHHcCChHhHHHHHhhccHHHHHHHHHhh Confidence 8876225677888899999999876 444333433 667777777664 No 140 >3NMZ_A APC variant protein, Rho guanine; protein-protein complex, armadillo repeats, CELL; 3.01A {Homo sapiens} Probab=96.87 E-value=1.6e-06 Score=88.90 Aligned_cols=135 Identities=18% Similarity=0.233 Sum_probs=88.1 Template_Neff=12.000 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQ-LGGICKLVDLLR----SPNQNVQQAAAGALRNLV---F 316 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~-~~IL~~Ll~lL~----s~d~eVr~~AL~aLs~La---~ 316 (747) +++.+..++. ..+..++..++.+|.+++...+.....+.. .++++.+..++. ..+..++..++.++.+++ . T Consensus 287 ~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~a~~~l~~l~~~~~ 366 (458) T 3NMZ_A 287 SVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIA 366 (458) T ss_pred HHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCchhHHHHHHhcChHHHHHHHHcCCCCCCCHHHHHHHHHHHHHHHHHhc Confidence 4555666665 456778888999999988743333333333 566777777765 224566777888887765 2 Q NP_000290.2 317 RSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS-TDELKEELIA-DALPVLADRVII 381 (747) Q Consensus 317 ~~~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas-~~~~~~~Lve-giLe~Lv~LL~~ 381 (747) ........+...++++.+..++. ..++.++..++.+|..++. .......+.. ++++.|..++.. T Consensus 367 ~~~~~~~~l~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~~~l~~~~~~~~L~~ll~~ 432 (458) T 3NMZ_A 367 TNEDHRQILRENNCLQTLLQHLK-SHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHS 432 (458) T ss_pred CCHHHHHHHHHCCcHHHHHHHhC-CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCcHHHHHHHHhC Confidence 22223333344467777888886 5567889999999999987 3444444544 788888887754 No 141 >6SA7_B DARPin-Armadillo fusion C8long83; protein fusion, DARPin, Armadillo, shared; 3.3A {synthetic construct} Probab=96.87 E-value=1.6e-06 Score=89.20 Aligned_cols=134 Identities=26% Similarity=0.306 Sum_probs=91.2 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.+|.+++.........+...++++.+...+.+.++.++..++.+|..++.........+ T Consensus 300 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 379 (510) T 6SA7_B 300 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 379 (510) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHHSSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHHHHHhCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHHHH Confidence 45566666666677888889999998876544333344445677778888877778888899999999886544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.+|..++.... ....+.. ++++.|+.++. T Consensus 380 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 435 (510) T 6SA7_B 380 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLS 435 (510) T ss_dssp HHTTHHHHHHHHHT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHcChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCcHHHHHHHhc Confidence 44467777887776 5577888889999998865432 2223333 66777777664 No 142 >5TBK_C Importin subunit alpha-3, Regulator of; Nuclear Import, Importin alpha, RCC1; 3.45A {Homo sapiens} Probab=96.87 E-value=1.7e-06 Score=90.04 Aligned_cols=367 Identities=17% Similarity=0.192 Sum_probs=215.7 Template_Neff=12.200 Q NP_000290.2 246 TIPKAVQYLSSQ-DEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ss-d~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+... ++.++..++.++..++.........+...++++.+..++.+.++.++..++.++..++......... T Consensus 115 ~i~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 194 (521) T 5TBK_C 115 ILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDY 194 (521) T ss_dssp HHHHHHHHHHCCSCHHHHHHHHHHHHHHHTSCHHHHHHHHTTTCHHHHHHHTTCSCHHHHHHHHHHHHHHHHHCHHHHHH T ss_pred cHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCChHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 445555555543 6678888888888887654333333334467777888887777888999999999888654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...+++..+...+....+..++..++.++..++.......... .++++.+..++... ++++ T Consensus 195 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~v 258 (521) T 5TBK_C 195 VISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHT----------------DVNI 258 (521) T ss_dssp HHHTTCHHHHHTTCCTTSCHHHHHHHHHHHHHHHCCCSSCCCHHHHHHHHHHHHHHTTCS----------------CHHH T ss_pred HHHCCcHHHHHHHhCCCCCHHHHHHHHHHHHHHHcCCCCCCCHHHHHHHHHHHHHHhhCC----------------CHHH Confidence 33445677777777533344678888888888876533221111 15566666665431 2334 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..+|..-... .+ ..++.+. -.+++..|...+.. .+..-...++..|.++ T Consensus 259 ~~~a~~~L~~l~~~------~~--------------~~~~~~~-~~~~~~~l~~~l~~------~~~~v~~~a~~~L~~l 311 (521) T 5TBK_C 259 LVDTVWALSYLTDA------GN--------------EQIQMVI-DSGIVPHLVPLLSH------QEVKVQTAALRAVGNI 311 (521) T ss_dssp HHHHHHHHHHHHHH------CH--------------HHHHHHH-HTTCHHHHGGGGGC------SSHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhcc------Ch--------------HHHHHHH-HCChHHHHHHHhcC------CCHHHHHHHHHHHHHH Confidence 33343333221100 00 0000000 02333434333321 0111112222223332 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) ...- ......+.+.++++.|..++. +.++ T Consensus 312 ~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~ 340 (521) T 5TBK_C 312 VTGT--------------------------------------------------DEQTQVVLNCDALSHFPALLT-HPKE 340 (521) T ss_dssp HTSC--------------------------------------------------HHHHHHHHHTTCGGGHHHHHT-CSCH T ss_pred HcCC--------------------------------------------------HHHHHHHHhCCHHHhHHHHhh-CCCH Confidence 2110 000112234467788888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGNQVFPE 639 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~giI~~ 639 (747) .++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. . .. ..+...++++. T Consensus 341 ~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~l~~~~~~~~ 415 (521) T 5TBK_C 341 KINKEAVWFLSNITAGNQQ-----QVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPP 415 (521) T ss_dssp HHHHHHHHHHHHHTTSCHH-----HHHHHHTTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHSCHHHHHHHHTTTCHHH T ss_pred HHHHHHHHHHHHHhCCCHH-----HHHHHHHCCcHHHHHHHHHhCCHHHHHHHHHHHHHHHccCCHHHHHHHHHCCCHHH Confidence 8888999999999865332 223334557888888888887888999999999999864 2 11 22233467788 Q NP_000290.2 640 VTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA----KQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 640 Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~----~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) |..++.. .++.++..++.+|.+++...+... ..+.+.++++.|..++.+. ++.++..++.+|.+++... T Consensus 416 L~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~l~~~~~~~~l~~ll~~~-~~~v~~~a~~~L~~l~~~~ 488 (521) T 5TBK_C 416 FCNLLTV------KDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHE-NEDIYKLAYEIIDQFFSSD 488 (521) T ss_dssp HHGGGGS------SCHHHHHHHHHHHHHHHHHCSTTHHHHHHHHHHTTHHHHHHHHCSTT-CHHHHHHHHHHHHHHCCC- T ss_pred HHHHcCC------CCHHHHHHHHHHHHHHHHHhHHhHHHHHHHHHHCCHHHHHHHHhcCC-CHHHHHHHHHHHHHhcCCC Confidence 8888765 367888899999999887533211 2233446778888888766 7889999999999999766 Q NP_000290.2 716 ELQ 718 (747) Q Consensus 716 ~~~ 718 (747) +.. T Consensus 489 ~~~ 491 (521) T 5TBK_C 489 DID 491 (521) T ss_dssp --- T ss_pred CCC Confidence 543 No 143 >5TBK_D Importin subunit alpha-3, Regulator of; Nuclear Import, Importin alpha, RCC1; 3.45A {Homo sapiens} Probab=96.87 E-value=1.7e-06 Score=90.04 Aligned_cols=367 Identities=17% Similarity=0.192 Sum_probs=215.0 Template_Neff=12.200 Q NP_000290.2 246 TIPKAVQYLSSQ-DEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ss-d~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+... ++.++..++.++..++.........+...++++.+..++.+.++.++..++.++..++......... T Consensus 115 ~i~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 194 (521) T 5TBK_D 115 ILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDY 194 (521) T ss_dssp HHHHHHHHHHCCSCHHHHHHHHHHHHHHHTSCHHHHHHHHTTTCHHHHHHHTTCSCHHHHHHHHHHHHHHHHHCHHHHHH T ss_pred cHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCChHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 445555555543 6678888888888887654333333334467777888887777888999999999888654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELI--ADALPVLADRVIIPFSGWCDGNSNMSREVVDPEV 402 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lv--egiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~ 402 (747) +...+++..+...+....+..++..++.++..++.......... .++++.+..++... ++++ T Consensus 195 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~----------------~~~v 258 (521) T 5TBK_D 195 VISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHT----------------DVNI 258 (521) T ss_dssp HHHTCCHHHHHTTCCTTSCHHHHHHHHHHHHHHHCCCSSCCCHHHHHHHHHHHHHHTTCS----------------CHHH T ss_pred HHHCCcHHHHHHHhCCCCCHHHHHHHHHHHHHHHcCCCCCCCHHHHHHHHHHHHHHhhCC----------------CHHH Confidence 33445677777777533344678888888888876533221111 15566666665431 2334 Q NP_000290.2 403 FFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNL 482 (747) Q Consensus 403 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 482 (747) ...+..+|..-... .+ ..++.+. -.+++..|...+.. .+..-...++..|.++ T Consensus 259 ~~~a~~~L~~l~~~------~~--------------~~~~~~~-~~~~~~~l~~~l~~------~~~~v~~~a~~~L~~l 311 (521) T 5TBK_D 259 LVDTVWALSYLTDA------GN--------------EQIQMVI-DSGIVPHLVPLLSH------QEVKVQTAALRAVGNI 311 (521) T ss_dssp HHHHHHHHHHHHHH------CH--------------HHHHHHH-HTTCHHHHGGGGGC------SSHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhcc------Ch--------------HHHHHHH-HCChHHHHHHHhcC------CCHHHHHHHHHHHHHH Confidence 33343333221100 00 0000000 02333434333321 0111112222223332 Q NP_000290.2 483 SYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKD 562 (747) Q Consensus 483 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~ 562 (747) ...- ......+.+.++++.|..++. +.++ T Consensus 312 ~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~~ 340 (521) T 5TBK_D 312 VTGT--------------------------------------------------DEQTQVVLNCDALSHFPALLT-HPKE 340 (521) T ss_dssp HTSC--------------------------------------------------HHHHHHHHHTTCGGGHHHHHH-CSCH T ss_pred HcCC--------------------------------------------------HHHHHHHHhCCHHHhHHHHhh-CCCH Confidence 2110 000112234467788888887 4677 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P-LL-HRVMGNQVFPE 639 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~-e~-~~ll~~giI~~ 639 (747) .++..++.+|.+++...+. ....+...++++.|..++.+.++.++..++.+|.+++.. . .. ..+...++++. T Consensus 341 ~v~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~l~~~~~~~~ 415 (521) T 5TBK_D 341 KINKEAVWFLSNITAGNQQ-----QVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPP 415 (521) T ss_dssp HHHHHHHHHHHHHTTSCHH-----HHHHHHTTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHSCHHHHHHHHTTTCHHH T ss_pred HHHHHHHHHHHHHhCCCHH-----HHHHHHHCCcHHHHHHHHHhCCHHHHHHHHHHHHHHHccCCHHHHHHHHHCCCHHH Confidence 8888999999999865332 223334557888888888887888999999999999864 2 11 22233467788 Q NP_000290.2 640 VTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA----KQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 640 Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~----~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) |..++.. .++.++..++.+|.+++...+... ..+.+.++++.|..++.+. ++.++..++.+|.+++... T Consensus 416 L~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~l~~~~~~~~l~~ll~~~-~~~v~~~a~~~L~~l~~~~ 488 (521) T 5TBK_D 416 FCNLLTV------KDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHE-NEDIYKLAYEIIDQFFSSD 488 (521) T ss_dssp HHGGGGS------SCHHHHHHHHHHHHHHHHHCSTTHHHHHHHHHHTTHHHHHHHHTTCS-CHHHHHHHHHHHHHHCC-- T ss_pred HHHHcCC------CCHHHHHHHHHHHHHHHHHhHHhHHHHHHHHHHCCHHHHHHHHhcCC-CHHHHHHHHHHHHHhcCCC Confidence 8888765 367888899999999887533211 2233446778888888766 7889999999999999766 Q NP_000290.2 716 ELQ 718 (747) Q Consensus 716 ~~~ 718 (747) +.. T Consensus 489 ~~~ 491 (521) T 5TBK_D 489 DID 491 (521) T ss_dssp --- T ss_pred CCC Confidence 543 No 144 >6HB1_A Protein HGH1; solenoid protein, Armadillo repeat, CHAPERONE; 2.33A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=96.86 E-value=1.8e-06 Score=89.00 Aligned_cols=169 Identities=9% Similarity=0.050 Sum_probs=120.8 Template_Neff=10.100 Q NP_000290.2 547 DAIRTYLNLMGK--SKKDATLEACAGALQNLTASKGLMSSGMSQLIGL--KEKGLPQIARLLQSGNSDVVRSGASLLSNM 622 (747) Q Consensus 547 G~I~~LL~LL~s--s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~lli--e~giI~~Ll~LL~s~d~eVr~~AL~aLsnL 622 (747) ++++.|+.++.. +.++.++..++++|.+++.... ....+. +.++++.|+.++.+.+..++..++++|.++ T Consensus 51 ~~i~~Lv~ll~~~~~~~~~~~~~al~~L~~l~~~~~------~~~~l~~~~~g~i~~L~~ll~~~~~~~~~~a~~~L~nl 124 (369) T 6HB1_A 51 RPIKDIIKMIMDPEHGTRVIIQQGVTILVNLSEDKL------VRNIILSDDKKFLKFLVWKIVDLTNPNADIMCILLSNL 124 (369) T ss_dssp HHHHHHHHHHHCTTTCCHHHHHHHHHHHHHHTTSHH------HHHCCCCCSTHHHHHHHHHHHCTTCTTHHHHHHHHHHH T ss_pred hHHHHHHHHHhCcccCcHHHHHHHHHHHHHHhCCHH------HHHHHhhcChHHHHHHHHHHHcCCCccHHHHHHHHHHH Confidence 588999999952 1356788899999999986532 244445 689999999999887778889999999999 Q NP_000290.2 623 SRHPLLH-RV-------------------------MGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA 676 (747) Q Consensus 623 a~~~e~~-~l-------------------------l~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~ 676 (747) +...... .+ ...++++.|+.++.........++.++..++++|.+|+.. +..+ T Consensus 125 ~~~~~~~~~l~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~i~~Lv~~l~~~~~~~~~~~~~~~~a~~~l~~l~~~-~~~~ 203 (369) T 6HB1_A 125 AKDDGILAVLNIKRNSSGEEVDDGLKLAALNKEVFKSLRAMDCLMDCFVKGYDKKLTKYASFNYLAFFFADISRF-KLGR 203 (369) T ss_dssp TTSGGGGGGGGCBCSCSSSEEETTEEECCCCTTTCCCSBHHHHHHHHHHHCGGGSSCSSCCCTTHHHHHHHHTTS-HHHH T ss_pred ccChhHHHHHhhcCCCCCCchhhhHHHHHHcHHHHHHhhHHHHHHHHHhhcCcccCCchhchHHHHHHHHHHcCC-HHHH Confidence 9864332 22 1246778888887652000000456788899999999875 5666 Q NP_000290.2 677 KQYFSSS------MLNNIINLCR-SSASPKAAEAARLLLSDMWSSKELQGVLRQ 723 (747) Q Consensus 677 ~~Lve~g------iL~~Ll~LL~-s~~d~eVr~aAL~aLsnL~~~~~~~~~~~~ 723 (747) ..+.+.+ .+..++.++. +. +..++..++.+|.+++.+.+....+.. T Consensus 204 ~~l~~~g~~~~~~~l~~ll~~l~~~~-~~~~~~~a~~~L~nl~~~~~~~~~i~~ 256 (369) T 6HB1_A 204 MYFIEEQEYDGVVPISKLLVFTEKYD-AKVRREGVASTIKNSLFDSETHERLLK 256 (369) T ss_dssp HHHHSCCTTTCCCGGGGTGGGGGCTT-CHHHHHHHHHHHHHHTCCGGGHHHHHH T ss_pred HHHhhcccccCcccHHHHHHHhcccC-CHHHHHHHHHHHHHHhcCHHHHHHHhc Confidence 6677766 4666666665 34 678899999999999988775544443 No 145 >6HB2_D Protein HGH1; solenoid protein, Armadillo repeat, CHAPERONE; HET: MSE; 2.7A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=96.86 E-value=1.8e-06 Score=89.00 Aligned_cols=169 Identities=9% Similarity=0.050 Sum_probs=120.8 Template_Neff=10.100 Q NP_000290.2 547 DAIRTYLNLMGK--SKKDATLEACAGALQNLTASKGLMSSGMSQLIGL--KEKGLPQIARLLQSGNSDVVRSGASLLSNM 622 (747) Q Consensus 547 G~I~~LL~LL~s--s~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~lli--e~giI~~Ll~LL~s~d~eVr~~AL~aLsnL 622 (747) ++++.|+.++.. +.++.++..++++|.+++.... ....+. +.++++.|+.++.+.+..++..++++|.++ T Consensus 51 ~~i~~Lv~ll~~~~~~~~~~~~~al~~L~~l~~~~~------~~~~l~~~~~g~i~~L~~ll~~~~~~~~~~a~~~L~nl 124 (369) T 6HB2_D 51 RPIKDIIKMIMDPEHGTRVIIQQGVTILVNLSEDKL------VRNIILSDDKKFLKFLVWKIVDLTNPNADIMCILLSNL 124 (369) T ss_dssp HHHHHHHHHHHCTTTCCHHHHHHHHHHHHHHTTSHH------HHHCCCCCCTHHHHHHHHHHSCTTCTTHHHHHHHHHHH T ss_pred hHHHHHHHHHhCcccCcHHHHHHHHHHHHHHhCCHH------HHHHHhhcChHHHHHHHHHHHcCCCccHHHHHHHHHHH Confidence 588999999952 1356788899999999986532 244445 689999999999887778889999999999 Q NP_000290.2 623 SRHPLLH-RV-------------------------MGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA 676 (747) Q Consensus 623 a~~~e~~-~l-------------------------l~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~ 676 (747) +...... .+ ...++++.|+.++.........++.++..++++|.+|+.. +..+ T Consensus 125 ~~~~~~~~~l~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~i~~Lv~~l~~~~~~~~~~~~~~~~a~~~l~~l~~~-~~~~ 203 (369) T 6HB2_D 125 AKDDGILAVLNIKRNSSGEEVDDGLKLAALNKEVFKSLRAMDCLMDCFVKGYDKKLTKYASFNYLAFFFADISRF-KLGR 203 (369) T ss_dssp TTSGGGGGGGGCBCSCSSSEEETTEEECCCCTTTCCCSBHHHHHHHHHHHHGGGSSCSSCCCTTHHHHHHHHTTS-HHHH T ss_pred ccChhHHHHHhhcCCCCCCchhhhHHHHHHcHHHHHHhhHHHHHHHHHhhcCcccCCchhchHHHHHHHHHHcCC-HHHH Confidence 9864332 22 1246778888887652000000456788899999999875 5666 Q NP_000290.2 677 KQYFSSS------MLNNIINLCR-SSASPKAAEAARLLLSDMWSSKELQGVLRQ 723 (747) Q Consensus 677 ~~Lve~g------iL~~Ll~LL~-s~~d~eVr~aAL~aLsnL~~~~~~~~~~~~ 723 (747) ..+.+.+ .+..++.++. +. +..++..++.+|.+++.+.+....+.. T Consensus 204 ~~l~~~g~~~~~~~l~~ll~~l~~~~-~~~~~~~a~~~L~nl~~~~~~~~~i~~ 256 (369) T 6HB2_D 204 MYFIEEQEYDGVVPISKLLVFTEKYD-AKVRREGVASTIKNSLFDSETHERLLK 256 (369) T ss_dssp HHHHSCCTTTCSCTHHHHGGGGGCTT-CHHHHHHHHHHHHHHTCSGGGHHHHHH T ss_pred HHHhhcccccCcccHHHHHHHhcccC-CHHHHHHHHHHHHHHhcCHHHHHHHhc Confidence 6677766 4666666665 34 678899999999999988775544443 No 146 >5MFD_C YIIIM''6AII, Capsid decoration protein,pD_(KR)5; Designed armadillo repeat protein, peptide; HET: CA; 2.3A {synthetic construct} Probab=96.84 E-value=1.8e-06 Score=81.45 Aligned_cols=114 Identities=25% Similarity=0.284 Sum_probs=77.1 Template_Neff=13.300 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.+..++..++.++..+..........+ T Consensus 47 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 126 (328) T 5MFD_C 47 ALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAV 126 (328) T ss_dssp CHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred cHHHHHHHhcCCCHHHHHHHHHHHHHHhcCcHHHHHHHhhcCHHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45566666777777888899999988876543333333344567777777777777888889999988876533333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++..+... T Consensus 127 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 160 (328) T 5MFD_C 127 IDAGALPALVQLLS-SPNEQILQEALWTLGNIASG 160 (328) T ss_dssp HHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHTTS T ss_pred HHCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcC Confidence 33456667777775 45667777788888777653 No 147 >6SA7_B DARPin-Armadillo fusion C8long83; protein fusion, DARPin, Armadillo, shared; 3.3A {synthetic construct} Probab=96.84 E-value=1.8e-06 Score=88.77 Aligned_cols=115 Identities=27% Similarity=0.318 Sum_probs=78.7 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.+|..++.........+...++++.+..++.+.++.++..++.++..++.........+ T Consensus 384 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 463 (510) T 6SA7_B 384 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAV 463 (510) T ss_dssp HHHHHHHHHTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcCcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCchHHHHH Confidence 34445555555667778888888888865544433344445677888888887788889999999999985544433333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD 361 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~ 361 (747) ...++++.+..++. +.++.++..++.++..+.... T Consensus 464 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~ 498 (510) T 6SA7_B 464 KEAGALEKLEQLQS-HENEKIQKEAQEALEKLGSGG 498 (510) T ss_dssp HHTTHHHHHHHGGG-CSSHHHHHHHHHHHHHHTC-- T ss_pred HHCCHHHHHHHHhh-ccchHHHHHHHHHHHHHhhcc Confidence 34456777777776 556788888999888887643 No 148 >6S9O_F designed Armadillo repeat protein with; peptide binder, repeat protein, designed; HET: CA, EDO; 3.17A {synthetic construct} Probab=96.77 E-value=2.5e-06 Score=81.50 Aligned_cols=115 Identities=28% Similarity=0.317 Sum_probs=77.6 Template_Neff=13.100 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.+.+..++..++.++..++......... T Consensus 46 ~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 125 (344) T 6S9O_F 46 GALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALRNIASGGNEQIQA 125 (344) T ss_dssp TCHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHHHSCSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred ChHHHHHHHcCCCCHHHHHHHHHHHHHHhcCChhHHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCchHHHH Confidence 34556666677777788889999999887654333333334456777777777777788888999998887643333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) +...++++.+...+. ..++.++..++.++..++.. T Consensus 126 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 160 (344) T 6S9O_F 126 VIDAGALPALVQLLS-SPNEQILSSALGALSNIASG 160 (344) T ss_dssp HHHTTCHHHHHHHTT-CSCHHHHHHHHHHHHHHHTS T ss_pred HHhCCHHHHHHHHhc-CCcHHHHHHHHHHHHHHHcC Confidence 333456677777775 45667777888888877653 No 149 >1XM9_A plakophilin 1 Plakophilin-1; armadillo repeat, CELL ADHESION; 2.8A {Homo sapiens} SCOP: a.118.1.24 Probab=96.77 E-value=2.5e-06 Score=86.12 Aligned_cols=167 Identities=15% Similarity=0.182 Sum_probs=108.5 Template_Neff=12.600 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL----------------QS 606 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL----------------~s 606 (747) +++.++++.|+.++....++.++..++.+|.+++.... ....+. .++++.|+.++ .. T Consensus 82 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~------~~~~~~-~~~~~~l~~~l~~~~~~~~~~~~~~~~~~ 154 (457) T 1XM9_A 82 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE------LKEELI-ADALPVLADRVIIPFSGWCDGNSNMSREV 154 (457) T ss_dssp HHHTTCHHHHHHHHTTCCCHHHHHHHHHHHHHHHTSSS------THHHHH-HHHHHHCCCCCCHHHHTCC---------C T ss_pred HHhcChHHHHHHHhhhCCCHHHHHHHHHHHHHHhCCHH------HHHHHH-cchHHHHHHHhccccCCCCCCCCCccccc Confidence 45677888888888633566788889999999987422 123333 57888888888 56 Q NP_000290.2 607 GNSDVVRSGASLLSNMSRHPLL-HRVMG-NQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP----------- 673 (747) Q Consensus 607 ~d~eVr~~AL~aLsnLa~~~e~-~~ll~-~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~----------- 673 (747) .++.++..++++|.+++..... ..+.. .++++.++.++.........+..++..++.+|.+++...+ T Consensus 155 ~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~ 234 (457) T 1XM9_A 155 VDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLE 234 (457) T ss_dssp CCHHHHHHHHHHHHHHTTSHHHHHHHTTSTTHHHHHHHHHHHHHHHTCTTCTTHHHHHHHHHHHTTTHHHHSCCHHHHHH T ss_pred CCHHHHHHHHHHHHHHccChHHHHHHHhcccHHHHHHHHHHHhhhcCcCCHHHHHHHHHHHHHHhcccccCCCcchhhhh Confidence 6788899999999999976433 22332 3567777777764100000256788889999999886311 Q NP_000290.2 674 ---------------------------------------QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 674 ---------------------------------------e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) .....+...++++.++.++....+..++..++.+|.+++.. T Consensus 235 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~ 314 (457) T 1XM9_A 235 YNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTAS 314 (457) T ss_dssp HTC----------------------------CCCCCSSCCGGGGGGSHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTC T ss_pred hcccccccccccccccCcccchhccccccCCCCcccCCCchhHHhhchhHHHHHHHHhccCCCHHHHHHHHHHHHHHHhc Confidence 11122334456667777766532556677788888887765 Q NP_000290.2 715 KE 716 (747) Q Consensus 715 ~~ 716 (747) .+ T Consensus 315 ~~ 316 (457) T 1XM9_A 315 KG 316 (457) T ss_dssp SS T ss_pred cc Confidence 54 No 150 >4HXT_A De Novo Protein OR329; Structural Genomics, PSI-Biology, Protein Structure; 1.95A {artificial gene} Probab=96.77 E-value=2.5e-06 Score=77.32 Aligned_cols=114 Identities=27% Similarity=0.311 Sum_probs=76.9 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++.........+...++++.+...+.+.++.++..++.++..++...+.....+ T Consensus 129 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 208 (252) T 4HXT_A 129 GVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPTSAIKAI 208 (252) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSBHHHHHHH T ss_pred HHHHHHHHhhCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 34555555666667788888888888876543333333344567777777777777888889999988886544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++.+++.. T Consensus 209 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~ 242 (252) T 4HXT_A 209 VDAGGVEVLQKLLT-STDSEVQKEAQRALENIKSG 242 (252) T ss_dssp HHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHHHT T ss_pred HHCCHHHHHHHHhc-CCCHHHHHHHHHHHHHHHcC Confidence 33356777777776 45677888888888888764 No 151 >6SA6_A DARPin-Armadillo fusion A5; protein fusion, DARPin, Armadillo, shared; HET: EDO; 1.6A {synthetic construct} Probab=96.73 E-value=3e-06 Score=84.23 Aligned_cols=132 Identities=23% Similarity=0.240 Sum_probs=87.4 Template_Neff=12.400 Q NP_000290.2 248 PKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRR 327 (747) Q Consensus 248 ~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~ 327 (747) ..++..+.+.+..++..++.++.+++.........+...++++.+..++.+.++.++..++.++.+++.........+.. T Consensus 160 ~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~ 239 (397) T 6SA6_A 160 AALVLKLNANDDQIIQEALWKLGNHASGGNLRIQWVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVID 239 (397) T ss_dssp HHHHHHTTCSCHHHHHHHHHHHHHHHTTTHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHH T ss_pred HHHHHHccCCCHHHHHHHHHHHHHHhhCCchHHHHHHHCCcHHHHHHHcCCCCHHHHHHHHHHHHHHhCCCHHHHHHHHH Confidence 34445555567788889999999988755444444445567788888888777788889999999988654443334444 Q NP_000290.2 328 QNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 328 ~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) .++++.+..++. ..++.++..++.++.+++..... ...+.. ++++.|+.+|. T Consensus 240 ~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 293 (397) T 6SA6_A 240 AGALPALVQLLS-SPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLS 293 (397) T ss_dssp TTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred CCcHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCcHHHHHHHHhCChHHHHHHHhc Confidence 567777888876 55677888888888888654222 222222 45555555543 No 152 >3NMZ_A APC variant protein, Rho guanine; protein-protein complex, armadillo repeats, CELL; 3.01A {Homo sapiens} Probab=96.71 E-value=3.3e-06 Score=86.51 Aligned_cols=135 Identities=22% Similarity=0.327 Sum_probs=88.0 Template_Neff=12.000 Q NP_000290.2 246 TIPKAVQYLSSQ-----------DEKYQAIGAYYIQHTCFQDESAKQQVYQ-LGGICKLVDLLRSPNQNVQQAAAGALRN 313 (747) Q Consensus 246 iL~~Ll~lL~ss-----------d~eVr~sAL~aLsnLs~~~~~~~~~li~-~~IL~~Ll~lL~s~d~eVr~~AL~aLs~ 313 (747) +++.+..++... +..++..++.+|.+++.........+.. .++++.+..++...+..++..++.++.+ T Consensus 190 ~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~a~~~L~~ 269 (458) T 3NMZ_A 190 GLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRN 269 (458) T ss_pred hHHHHHHHHhccccCCCCCCCCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHhCCcHHHHHHHhcCCCHHHHHHHHHHHHH Confidence 445555555543 5678888999999988754433332333 4677888888877778889999999999 Q NP_000290.2 314 LVFRST-TNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST-DELKEELI--ADALPVLADRVI 380 (747) Q Consensus 314 La~~~~-~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~-~~~~~~Lv--egiLe~Lv~LL~ 380 (747) ++.... .....+...++++.+..++....+..++..++.++.+++.. ......+. .++++.|+.++. T Consensus 270 l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 340 (458) T 3NMZ_A 270 LSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLT 340 (458) T ss_pred HHCCCChhHHHHHHHCCHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCchhHHHHHHhcChHHHHHHHHc Confidence 886543 22333444457777777775234567888889999998873 33333333 256666666654 No 153 >6HB1_A Protein HGH1; solenoid protein, Armadillo repeat, CHAPERONE; 2.33A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=96.61 E-value=5.3e-06 Score=85.37 Aligned_cols=93 Identities=22% Similarity=0.297 Sum_probs=66.7 Template_Neff=10.100 Q NP_000290.2 287 GGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ--NGIREAVSLLRR--TGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 287 ~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~--~IL~~Ll~lL~s--s~d~eVr~~AL~aLsnLas~~~ 362 (747) +.++.++.++...++.++..++.++.++..... ...+... +.++.|+.++.. ..++.++..++.+|.+++.... T Consensus 9 ~~i~~lv~lL~~~~~~v~~~a~~~L~~l~~~~~--~~~l~~~~~~~i~~Lv~ll~~~~~~~~~~~~~al~~L~~l~~~~~ 86 (369) T 6HB1_A 9 SQLNELVEFLHSPQPAVRQIAIDNLVGFSAGPT--SKVFKNDSYRPIKDIIKMIMDPEHGTRVIIQQGVTILVNLSEDKL 86 (369) T ss_dssp CCHHHHHHGGGCSCHHHHHHHHHHHGGGGSSGG--GGGGGHHHHHHHHHHHHHHHCTTTCCHHHHHHHHHHHHHHTTSHH T ss_pred hhHHHHHHHhcCCCHHHHHHHHHHHhHhcCCCC--chhhhcCCchHHHHHHHHHhCcccCcHHHHHHHHHHHHHHhCCHH Confidence 456677777777777888899999988876543 2333333 478888888852 1356788899999999987655 Q NP_000290.2 363 LKEELI--A-DALPVLADRVII 381 (747) Q Consensus 363 ~~~~Lv--e-giLe~Lv~LL~~ 381 (747) ....+. + ++++.|+.++.. T Consensus 87 ~~~~l~~~~~g~i~~L~~ll~~ 108 (369) T 6HB1_A 87 VRNIILSDDKKFLKFLVWKIVD 108 (369) T ss_dssp HHHCCCCCSTHHHHHHHHHHHC T ss_pred HHHHHhhcChHHHHHHHHHHHc Confidence 556666 5 888888888874 No 154 >6HB2_D Protein HGH1; solenoid protein, Armadillo repeat, CHAPERONE; HET: MSE; 2.7A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=96.61 E-value=5.3e-06 Score=85.37 Aligned_cols=93 Identities=22% Similarity=0.297 Sum_probs=66.7 Template_Neff=10.100 Q NP_000290.2 287 GGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ--NGIREAVSLLRR--TGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 287 ~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~--~IL~~Ll~lL~s--s~d~eVr~~AL~aLsnLas~~~ 362 (747) +.++.++.++...++.++..++.++.++..... ...+... +.++.|+.++.. ..++.++..++.+|.+++.... T Consensus 9 ~~i~~lv~lL~~~~~~v~~~a~~~L~~l~~~~~--~~~l~~~~~~~i~~Lv~ll~~~~~~~~~~~~~al~~L~~l~~~~~ 86 (369) T 6HB2_D 9 SQLNELVEFLHSPQPAVRQIAIDNLVGFSAGPT--SKVFKNDSYRPIKDIIKMIMDPEHGTRVIIQQGVTILVNLSEDKL 86 (369) T ss_dssp HHHHHHHGGGGCSCHHHHHHHHHHHGGGGSSGG--GGGGGHHHHHHHHHHHHHHHCTTTCCHHHHHHHHHHHHHHTTSHH T ss_pred hhHHHHHHHhcCCCHHHHHHHHHHHhHhcCCCC--chhhhcCCchHHHHHHHHHhCcccCcHHHHHHHHHHHHHHhCCHH Confidence 456677777777777888899999988876543 2333333 478888888852 1356788899999999987655 Q NP_000290.2 363 LKEELI--A-DALPVLADRVII 381 (747) Q Consensus 363 ~~~~Lv--e-giLe~Lv~LL~~ 381 (747) ....+. + ++++.|+.++.. T Consensus 87 ~~~~l~~~~~g~i~~L~~ll~~ 108 (369) T 6HB2_D 87 VRNIILSDDKKFLKFLVWKIVD 108 (369) T ss_dssp HHHCCCCCCTHHHHHHHHHHSC T ss_pred HHHHHhhcChHHHHHHHHHHHc Confidence 556666 5 888888888874 No 155 >2W3C_A GENERAL VESICULAR TRANSPORT FACTOR P115; MEMBRANE VESICLE TETHERING, ARMADILLO FOLD; HET: PEG; 2.22A {HOMO SAPIENS} Probab=96.59 E-value=5.7e-06 Score=90.00 Aligned_cols=135 Identities=13% Similarity=0.124 Sum_probs=95.4 Template_Neff=10.400 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDE-SAKQQVY-QLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~-~~~~~li-~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .++.++.++.+.+..++..++.+|..++...+ .....+. ..+.++.++.++.+.+..++..++.+|..++........ T Consensus 71 ~i~~L~~ll~~~~~~v~~~a~~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~~~~~~~~~~a~~~L~~l~~~~~~~~~ 150 (577) T 2W3C_A 71 NVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQK 150 (577) T ss_dssp HHHHHHHHTTCCCHHHHHHHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHHGGGGCSSHHHHHHHHHHHHHHHTTCHHHHH T ss_pred hHHHHHHHccCCCHHHHHHHHHHHHHHHHhchHHHHHHHHhCCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHH Confidence 45566666766778889999999999987543 2222333 246788888888877788899999999999875444444 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGN----AEIQKQLTGLLWNLSSTDELKEEL-IA-DALPVLADRVII 381 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d----~eVr~~AL~aLsnLas~~~~~~~L-ve-giLe~Lv~LL~~ 381 (747) .+...+.++.|+.++. ... ..++..++.+|.+++........+ .+ ++++.|+.+|.. T Consensus 151 ~~~~~g~~~~L~~ll~-~~~~~~~~~v~~~al~~L~~l~~~~~~~~~~~~~~~~i~~L~~lL~~ 213 (577) T 2W3C_A 151 IVAFENAFERLLDIIS-EEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYIQRMKPWFEV 213 (577) T ss_dssp HHHHTTHHHHHHHHHH-HTTGGGSCHHHHHHHHHHHHHHTTCHHHHHHHHHTTCGGGGSGGGCC T ss_pred HHHcCCHHHHHHHHHH-HhCCCCCcHHHHHHHHHHHHHHccCHHHHHHHHhcChHHHHHHHHhc Confidence 4444678888888886 322 257788899999998765433333 34 788889888875 No 156 >4XZR_B Heh1-NLS, Kap60; karyopherins nuclear import ; 2.25A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=96.58 E-value=5.2e-06 Score=81.38 Aligned_cols=114 Identities=19% Similarity=0.154 Sum_probs=76.5 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.+..++..++.++..++.......... T Consensus 172 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 251 (423) T 4XZR_B 172 ALPTLAKLIYSMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVV 251 (423) T ss_dssp GHHHHHHHTTCSCHHHHHHHHHHHHHHTSSSHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHhcCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666677788888888888876544333334444567777777777777888889999988876543332223 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++..++.. T Consensus 252 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 285 (423) T 4XZR_B 252 INAGVLPALRLLLS-SPKENIKKEACWTISNITAG 285 (423) T ss_dssp HHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHTTS T ss_pred HHcChHHHHHHHhc-CCCHHHHHHHHHHHHHHhcC Confidence 33356667777775 45667777888888877764 No 157 >3TT9_A Plakophilin-2; CELL ADHESION; HET: GOL; 1.55A {Homo sapiens} Probab=96.56 E-value=6e-06 Score=75.59 Aligned_cols=136 Identities=22% Similarity=0.238 Sum_probs=88.7 Template_Neff=12.300 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+..++.+.+..++..++.+|.+++.........+...+.++.++.++. ..+..++..++.++.+++... ..... T Consensus 53 ~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~-~~~~~ 131 (233) T 3TT9_A 53 GILKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNKLEVAELNGVPRLLQVLKQTRDLETKKQITGLLWNLSSND-KLKNL 131 (233) T ss_dssp HHHHHHHGGGCCCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHHTSG-GGHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCCcHHHHHHHcccHHHHHHHHhhCCCHHHHHHHHHHHHHHccCH-HHHHH Confidence 4556666676667788889999999988644444444555577788888887 556778888999999987643 22233 Q NP_000290.2 325 TRRQNGIREAVSLLRRT--------------GNAEIQKQLTGLLWNLSS-TDELKEELIA-DA-LPVLADRVIIP 382 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss--------------~d~eVr~~AL~aLsnLas-~~~~~~~Lve-gi-Le~Lv~LL~~~ 382 (747) +...+++..+..++... .+..++..++.++.+++. .......+.. +. ++.|+.++... T Consensus 132 ~~~~~~~~~l~~ll~~~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~ 206 (233) T 3TT9_A 132 MITEALLTLTENIIIPFSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGADGRKAMRRCDGLIDSLVHYVRGT 206 (233) T ss_dssp HHHHHHHHHCCCCCHHHHCCCGGGCCCCCTTCCHHHHHHHHHHHHHHTTSCHHHHHHHHTSTTHHHHHHHHHHHH T ss_pred hhhhcHHHHHHHHHhhccCCCCCCCCcccCCCcHHHHHHHHHHHHHHHhcCHHHHHHHHHcccHHHHHHHHHHcc Confidence 33334455555554311 135677888899999887 4444444444 55 78888877653 No 158 >6HB3_B Protein HGH1; solenoid protein, Armadillo repeat, CHAPERONE; 3.0A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=96.56 E-value=6.6e-06 Score=84.61 Aligned_cols=93 Identities=22% Similarity=0.297 Sum_probs=66.7 Template_Neff=10.100 Q NP_000290.2 287 GGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ--NGIREAVSLLRR--TGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 287 ~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~--~IL~~Ll~lL~s--s~d~eVr~~AL~aLsnLas~~~ 362 (747) +.++.++.++...+..++..++.++.++..... ...+... +.++.|+.++.. ..+..++..++.+|.+++.... T Consensus 9 ~~~~~lv~lL~~~~~~v~~~a~~~L~~l~~~~~--~~~l~~~~~~~i~~Lv~ll~~~~~~~~~~~~~al~~L~~l~~~~~ 86 (369) T 6HB3_B 9 SQLNELVEFLHSPQPAVRQIAIDNLVGFSAGPT--SKVFKNDSYRPIKDIIKMIMDPEHGTRVIIQQGVTILVNLSEDKL 86 (369) T ss_pred CcHHHHHHHccCCCHHHHHHHHHHHHHHcCChh--HHHHHHhCCCcHHHHHHHHhCCCCCCHHHHHHHHHHHHHHcCCHH Confidence 456677777776677888899999988876543 2333333 478888888852 1356788899999999987655 Q NP_000290.2 363 LKEELI--A-DALPVLADRVII 381 (747) Q Consensus 363 ~~~~Lv--e-giLe~Lv~LL~~ 381 (747) ....+. . ++++.|+.+|.. T Consensus 87 ~~~~l~~~~~g~i~~L~~ll~~ 108 (369) T 6HB3_B 87 VRNIILSDDKKFLKFLVWKIVD 108 (369) T ss_pred HHHHHHhccCCcHHHHHHHhcC Confidence 556666 5 888888888874 No 159 >6SA8_A ring-like DARPin-Armadillo fusion H83_D01, LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG; protein fusion, DARPin, Armadillo, shared; 2.4A {synthetic construct} Probab=96.54 E-value=6.4e-06 Score=88.93 Aligned_cols=322 Identities=20% Similarity=0.248 Sum_probs=204.5 Template_Neff=11.900 Q NP_000290.2 286 LGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELK 364 (747) Q Consensus 286 ~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~ 364 (747) ...++.+...+...+..++..++.+|..++.........+...++++.+...+. ..++.++..++.++..++... ... T Consensus 177 ~~~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~L~~l~~~~~~~~ 255 (671) T 6SA8_A 177 KKILKDLVKKLSSPNENELQNALWTLGNIASGGNEQIQAVIDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQI 255 (671) T ss_dssp HHHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHTTSCHHHH T ss_pred HHHHHHHHHhcCCCCHHHHHHHHHHHHHHHcCCcHHHHHHHHcChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCChHHH Confidence 355667777777777778888888888887654333333444567777888886 557788999999999988743 222 Q NP_000290.2 365 EELIA-DALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQT 443 (747) Q Consensus 365 ~~Lve-giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 443 (747) ..+.. ++++.|+.++.. .++++-..+..+|..-. .. ....+.. T Consensus 256 ~~~~~~~~~~~l~~~l~~----------------~~~~v~~~a~~~L~~l~---------~~-----------~~~~~~~ 299 (671) T 6SA8_A 256 QAVIDAGALPALVQLLSS----------------PNEQILQEALWALSNIA---------SG-----------GNEQIQA 299 (671) T ss_dssp HHHHHTTCHHHHHHHTTC----------------SCHHHHHHHHHHHHHHT---------TS-----------CHHHHHH T ss_pred HHHHHcCHHHHHHHHhcC----------------CCHHHHHHHHHHHHHHH---------cC-----------CcHHHHH Confidence 33333 677777777753 13444444444443211 00 0001111 Q NP_000290.2 444 MRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMN 523 (747) Q Consensus 444 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 523 (747) . -..++++.|+..++. .+..-...+...|.++.... T Consensus 300 ~-~~~~~~~~L~~~l~~------~~~~v~~~a~~~L~~l~~~~------------------------------------- 335 (671) T 6SA8_A 300 V-IDAGALPALVQLLSS------PNEQILQEALWALSNIASGG------------------------------------- 335 (671) T ss_dssp H-HHTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHTTSC------------------------------------- T ss_pred H-HHhChHHHHHHHhcC------CcHHHHHHHHHHHHHHhcCC------------------------------------- Confidence 1 113455555544431 11112222333333332110 Q NP_000290.2 524 NNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARL 603 (747) Q Consensus 524 ~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~L 603 (747) ......+.+.++++.|+.++. ..++.++..++.+|.+++...+. ....+...++++.|+.+ T Consensus 336 -------------~~~~~~~~~~~~l~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~ 396 (671) T 6SA8_A 336 -------------NEQIQAVIDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNE-----QIQAVIDAGALPALVQL 396 (671) T ss_dssp -------------HHHHHHHHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHG T ss_pred -------------cHHHHHHHhcChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCcH-----HHHHHHHcCcHHHHHHH Confidence 001112345667888888887 46778888999999999874332 23333456788899999 Q NP_000290.2 604 LQSGNSDVVRSGASLLSNMSRHP-LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFS 681 (747) Q Consensus 604 L~s~d~eVr~~AL~aLsnLa~~~-e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve 681 (747) +.+.++.++..++.+|.+++... .. ......++++.|+.++.+ .++.++..++.+|.+++...+.....+.+ T Consensus 397 l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~L~~~l~~------~~~~v~~~a~~~L~~l~~~~~~~~~~~~~ 470 (671) T 6SA8_A 397 LSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSS------PNEQILQEALWALSNIASGGNEQIQAVID 470 (671) T ss_dssp GGCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHGGGC------SCHHHHHHHHHHHHHHHTSCHHHHHHHHH T ss_pred hcCCCHHHHHHHHHHHHhhcCCCHHHHHHHHhcCcHHHHHHHcCC------CCHHHHHHHHHHHHHHHcCChHHHHHHHh Confidence 98888899999999999998762 22 233445678888888876 36788999999999999765544455556 Q NP_000290.2 682 SSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 682 ~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) .++++.|+.++.+. ++.++..++.+|.+++.. T Consensus 471 ~~~~~~l~~~l~~~-~~~v~~~a~~~l~~l~~~ 502 (671) T 6SA8_A 471 AGALPALVQLLSSP-NEQIQDEAEKTLLNIANG 502 (671) T ss_dssp TTHHHHHHHHTTCS-CHHHHHHHHHHHHHHHTS T ss_pred cCcHHHHHHHhhCC-CHHHHHHHHHHHHHHHcC Confidence 67788888888876 788899999999998854 No 160 >1EE4_A KARYOPHERIN ALPHA; ARM repeat, TRANSPORT PROTEIN; 2.1A {Saccharomyces cerevisiae} SCOP: a.118.1.1 Probab=96.51 E-value=6.8e-06 Score=80.51 Aligned_cols=114 Identities=22% Similarity=0.183 Sum_probs=77.4 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..............++++.+...+.+.++.++..++.++..++...+.....+ T Consensus 214 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 293 (423) T 1EE4_A 214 IPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAV 293 (423) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHhcCCCcchhHHHHHHHHHHHhCChHHHHHHHHcChHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 44556666666677888889999988876543333333334667777777777777888899999988876544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++..++.. T Consensus 294 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 327 (423) T 1EE4_A 294 IDANLIPPLVKLLE-VAEDKTKKEACWAISNASSG 327 (423) T ss_dssp HHTTCHHHHHHHHH-HSCHHHHHHHHHHHHHHHGG T ss_pred HHCCcHHHHHHHHh-cCCHHHHHHHHHHHHHHHcC Confidence 34456677777775 55667788888888887764 No 161 >1EE4_B KARYOPHERIN ALPHA; ARM repeat, TRANSPORT PROTEIN; 2.1A {Saccharomyces cerevisiae} SCOP: a.118.1.1 Probab=96.51 E-value=6.8e-06 Score=80.51 Aligned_cols=114 Identities=22% Similarity=0.183 Sum_probs=77.4 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..............++++.+...+.+.++.++..++.++..++...+.....+ T Consensus 214 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 293 (423) T 1EE4_B 214 IPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAV 293 (423) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred HHHHHHHHhcCCCcchhHHHHHHHHHHHhCChHHHHHHHHcChHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 44556666666677888889999988876543333333334667777777777777888899999988876544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++..++.. T Consensus 294 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 327 (423) T 1EE4_B 294 IDANLIPPLVKLLE-VAEDKTKKEACWAISNASSG 327 (423) T ss_dssp HHTTCHHHHHHHHH-HSCHHHHHHHHHHHHHHHGG T ss_pred HHCCcHHHHHHHHh-cCCHHHHHHHHHHHHHHHcC Confidence 34456677777775 55667788888888887764 No 162 >5KC2_B Phosphatidylinositol 3-kinase VPS34 (E.C.2.7.1.137), Serine/threonine-protein; autophagy, phosphatidylinositol 3-kinase (PtdIns3K), endocytosis; 28.0A {Saccharomyces cerevisiae} Probab=96.45 E-value=9.9e-06 Score=98.55 Aligned_cols=150 Identities=9% Similarity=0.041 Sum_probs=112.4 Template_Neff=9.500 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++++.|+.+|. +.++.++..|+.+|..++.... ...+.+.. ++.|+.+|.+.++.++..++.+|++|+.. T Consensus 618 ~~~l~~L~~~l~-d~~~~vR~~a~~al~~l~~~~~-------~~~~~~~~-lp~L~~lL~d~~~~vr~~al~aL~~L~~~ 688 (1454) T 5KC2_B 618 DIILSHLITYLN-DKDPALRVSLIQTISGISILLG-------TVTLEQYI-LPLLIQTITDSEELVVISVLQSLKSLFKT 688 (1454) T ss_pred hhhHHHHHHHcc-CCCHHHHHHHHHHHHHHHHhhH-------HHHHHHcC-HHHHHHHhcCCCHHHHHHHHHHHHHHhhC Confidence 346788889998 5888999999999999986431 22223333 89999999988889999999999999876 Q NP_000290.2 626 P-LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 626 ~-e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . .....+.. +++.+..++.+ .++.++..++.+|..|+..... .... ..+++.|+.+|.+. +..+++.| T Consensus 689 ~~~~~~~~~~-~l~~l~~~l~~------~~~~vr~~a~~~L~~l~~~~~~--~~~~-~~~~~~L~~~L~d~-~~~vr~~a 757 (1454) T 5KC2_B 689 GLIRKKYYID-ISKTTSPLLLH------PNNWIRQFTLMIIIEIINKLSK--AEVY-CILYPIIRPFFEFD-VEFNFKSM 757 (1454) T ss_pred CHHHHHHHHH-HHHHHHHHHCC------CCHHHHHHHHHHHHHHhcCCCC--HHHH-cChHHHHHHHhcCC-CHHHHHHH Confidence 3 22222222 66777777766 3788999999999999875321 1122 45788899999877 88999999 Q NP_000290.2 705 RLLLSDMWSSK 715 (747) Q Consensus 705 L~aLsnL~~~~ 715 (747) +.+|..++..+ T Consensus 758 ~~~L~~~~~~~ 768 (1454) T 5KC2_B 758 ISCCKQPVSRS 768 (1454) T ss_pred HHHHHHHhhcc Confidence 99999988765 No 163 >4B18_A IMPORTIN SUBUNIT ALPHA-1, TELOMERASE REVERSE; TRANSPORT PROTEIN - PEPTIDE COMPLEX; 2.52A {HOMO SAPIENS} Probab=96.44 E-value=8.9e-06 Score=80.74 Aligned_cols=366 Identities=18% Similarity=0.167 Sum_probs=217.7 Template_Neff=13.000 Q NP_000290.2 245 LTIPKAVQYLSS-QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~s-sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .+++.+...+.. .++.++..++.++..++.........+...++++.+...+.+.+..++..++.++..++........ T Consensus 61 ~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~ 140 (447) T 4B18_A 61 GVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRD 140 (447) T ss_dssp THHHHHHHHTTCTTCHHHHHHHHHHHHHHTSSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHH T ss_pred cHHHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCcHHHHHHHHcChHHHHHHHhhCCCHHHHHHHHHHHHHHHccChhHHH Confidence 345556666655 5677888889999888765433333333456777888888777788889999999988765443333 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVIIPFSGWCDGNSNMSREVVDPE 401 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~ 401 (747) .+...++++.+...+....++.++..++.++..++........... ++++.+..++.. .+++ T Consensus 141 ~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~ 204 (447) T 4B18_A 141 YVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFV----------------SDTD 204 (447) T ss_dssp HHHHTTCHHHHHHGGGCTTCHHHHHHHHHHHHHHHCCSSSCCCHHHHGGGHHHHHHHTTS----------------CCHH T ss_pred HHHHCCcHHHHHHHhhcCCChhHHHHHHHHHHHHhcCCCCCCcccccccHHHHHHHHhhC----------------CCHH Confidence 3334456777777775333457888888999888765432222211 455556655532 1334 Q NP_000290.2 402 VFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHN 481 (747) Q Consensus 402 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 481 (747) +...+..++..-... -+ ...+.+. -.+++..|...+.. .+..-.+.+...|.+ T Consensus 205 ~~~~a~~~l~~l~~~------~~--------------~~~~~~~-~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~ 257 (447) T 4B18_A 205 VLADACWALSYLSDG------PN--------------DKIQAVI-DAGVCRRLVELLMH------NDYKVVSPALRAVGN 257 (447) T ss_dssp HHHHHHHHHHHHTSS------SH--------------HHHHHHH-HTTCHHHHHHHTTC------SCHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHhcC------CH--------------HHHHHHH-HCCHHHHHHHHHcC------CCHHHHHHHHHHHHH Confidence 444444333221100 00 0000000 12333333333321 111112222222322 Q NP_000290.2 482 LSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKK 561 (747) Q Consensus 482 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d 561 (747) +.... ......+.+.++++.|+.++. +.+ T Consensus 258 l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~ 286 (447) T 4B18_A 258 IVTGD--------------------------------------------------DIQTQVILNCSALQSLLHLLS-SPK 286 (447) T ss_dssp HTTSC--------------------------------------------------HHHHHHHHHTTHHHHHHHHTT-CSS T ss_pred HhcCC--------------------------------------------------hHHHHHHhhcchHHHHHHHhc-CCC Confidence 22110 000112234567888888887 467 Q NP_000290.2 562 DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH--PLL-HRVMGNQVFP 638 (747) Q Consensus 562 ~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~--~e~-~~ll~~giI~ 638 (747) +.++..++.+|.+++..... ....+...++++.+..++.+.++.++..++.+|.+++.. ... ..+...++++ T Consensus 287 ~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~ 361 (447) T 4B18_A 287 ESIKKEACWTISNITAGNRA-----QIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIK 361 (447) T ss_dssp HHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHTCHH T ss_pred HHHHHHHHHHHHHHhcCCHH-----HHHHHHhCChHHHHHHHHhcCCHHHHHHHHHHHHHHhccCCHHHHHHHHHCCcHH Confidence 78888999999999875332 223334567888899998888888999999999999875 222 2334446778 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK-----------QYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~-----------~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) .+..++.+ .++.++..++.+|.+++...+.... .+.+.++++.+..++.+. ++.++..++.+ T Consensus 362 ~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~~-~~~v~~~a~~~ 434 (447) T 4B18_A 362 PLCDLLTV------MDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQSHE-NQEIYQKAFDL 434 (447) T ss_dssp HHHHGGGS------SCHHHHHHHHHHHHHHHHHHHHHHHHSSCCSCHHHHHHHHTTHHHHHHHGGGSS-CHHHHHHHHHH T ss_pred HHHHHhhC------CCHHHHHHHHHHHHHHHHHhHHHHhhCCCCCCHHHHHHHHhccHHHHHHHHhCC-CHHHHHHHHHH Confidence 88888776 3678889999999999875332221 233445677777777666 77889999999 Q NP_000290.2 708 LSDMWSSKE 716 (747) Q Consensus 708 LsnL~~~~~ 716 (747) +.++....+ T Consensus 435 l~~l~~~~~ 443 (447) T 4B18_A 435 IEHYFGTED 443 (447) T ss_dssp HHHHCC--- T ss_pred HHHHhcCcc Confidence 988876543 No 164 >1JDH_A BETA-CATENIN, hTcf-4; BETA-CATENIN, TCF4, PROTEIN-PROTEIN COMPLEX, TRANSCRIPTION; 1.9A {Homo sapiens} SCOP: a.118.1.1 Probab=96.44 E-value=9e-06 Score=82.47 Aligned_cols=363 Identities=19% Similarity=0.190 Sum_probs=216.7 Template_Neff=13.100 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP-NQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~-d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .+++.+...+.+.++.++..++.++..+....+.....+...++++.+...+... +..++..++.++..+..... ... T Consensus 143 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~-~~~ 221 (529) T 1JDH_A 143 GGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSS-NKP 221 (529) T ss_dssp THHHHHHHGGGCCCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTSTT-HHH T ss_pred ChHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCChhHHHHHHHccCCcHHHHHHHHHHHHHHhcCCc-cHH Confidence 3455666667667788888999999988754444333444455777777777654 56778888888888875432 222 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) .+...++++.+...+. ..++.++..++.++..++....... ...++++.+..++.. -++++. T Consensus 222 ~~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~-~~~~~~~~l~~~l~~----------------~~~~~~ 283 (529) T 1JDH_A 222 AIVEAGGMQALGLHLT-DPSQRLVQNCLWTLRNLSDAATKQE-GMEGLLGTLVQLLGS----------------DDINVV 283 (529) T ss_dssp HHHHTTHHHHHHTTTT-SSCHHHHHHHHHHHHHHHTTCTTCS-CCHHHHHHHHHHTTC----------------SCHHHH T ss_pred HHHHCCHHHHHHHHcc-CCCHHHHHHHHHHHHHHcchhhhHH-HHchHHHHHHHHhCC----------------CCHHHH Confidence 3333456777777776 4566788888888888876432211 112455556655541 123333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-... .+. .+..+ .-.+.++.++..+.. ..-+..-.+.+...|.++. T Consensus 284 ~~a~~~l~~l~~~------~~~--------------~~~~~-~~~~~~~~l~~~l~~----~~~~~~~~~~a~~~l~~l~ 338 (529) T 1JDH_A 284 TCAAGILSNLTCN------NYK--------------NKMMV-CQVGGIEALVRTVLR----AGDREDITEPAICALRHLT 338 (529) T ss_dssp HHHHHHHHHHTTT------CHH--------------HHHHH-HHTTHHHHHHHHHHH----HTTCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHhcC------CHH--------------HHHHH-HHcCHHHHHHHHHHh----cCCChHhHHHHHHHHHHHh Confidence 3333333221100 000 00000 012233333332211 0111222333444444443 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ....... .....+...++++.++.++....++. T Consensus 339 ~~~~~~~-----------------------------------------------~~~~~~~~~~~~~~l~~~l~~~~~~~ 371 (529) T 1JDH_A 339 SRHQEAE-----------------------------------------------MAQNAVRLHYGLPVVVKLLHPPSHWP 371 (529) T ss_dssp SSSTTHH-----------------------------------------------HHHHHHHHTTCHHHHHHTTSTTCCHH T ss_pred cCcccHH-----------------------------------------------HHHHHHHhcccHHHHHHHHCCCCCHH Confidence 2211000 00111234566778888887323667 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN----------------------SDVVRSGASLLSN 621 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d----------------------~eVr~~AL~aLsn 621 (747) ++..++.+|.+++.... ....+...++++.|..++.+.+ +.++..++.+|.+ T Consensus 372 ~~~~a~~~l~~l~~~~~------~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~ 445 (529) T 1JDH_A 372 LIKATVGLIRNLALCPA------NHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHI 445 (529) T ss_dssp HHHHHHHHHHHHTTSGG------GHHHHHHTTHHHHHHHHHHHHHHHHC-----------CBTTBCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHhcChh------hhHHHHhcCHHHHHHHHHHhcChhHHHHHhccCcchhHhccCCHHHHHHHHHHHHHH Confidence 88889999999887532 1333345678888888887654 6788889999999 Q NP_000290.2 622 MSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 622 La~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) ++..... ..+...++++.+..++.+ .++.++..++.+|.+++.. +.....+...++++.|..++.+. ++.+ T Consensus 446 l~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~-~~~~~~~~~~~~~~~l~~~l~~~-~~~v 517 (529) T 1JDH_A 446 LARDVHNRIVIRGLNTIPLFVQLLYS------PIENIQRVAAGVLCELAQD-KEAAEAIEAEGATAPLTELLHSR-NEGV 517 (529) T ss_dssp HTTSHHHHHHHHHTTCHHHHHHGGGC------SCHHHHHHHHHHHHHHTTS-HHHHHHHHHTTCHHHHHHGGGCS-SHHH T ss_pred HhcCccchHHHHhcCcHHHHHHHhcC------CCHHHHHHHHHHHHHHhcC-HHHHHHHHHcCcHHHHHHHHhcC-CHHH Confidence 9876433 233445677888888876 3678899999999999875 44455555667888899988876 7889 Q NP_000290.2 701 AEAARLLLSDMW 712 (747) Q Consensus 701 r~aAL~aLsnL~ 712 (747) +..++.+|.+++ T Consensus 518 ~~~a~~~L~~l~ 529 (529) T 1JDH_A 518 ATYAAAVLFRMS 529 (529) T ss_dssp HHHHHHHHHHHC T ss_pred HHHHHHHHHhcC Confidence 999999888763 No 165 >5MFI_B YIII(Dq.V2)4CqI, (KR)4; Designed armadillo repeat protein, peptide; 1.45A {synthetic construct} Probab=96.43 E-value=9.2e-06 Score=73.31 Aligned_cols=135 Identities=19% Similarity=0.216 Sum_probs=90.0 Template_Neff=13.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.+..++..++.++.++....+.....+...++++.+...+.+.+..++..++.++..++......... T Consensus 88 ~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~ 167 (243) T 5MFI_B 88 GALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQK 167 (243) T ss_dssp TCHHHHHHHTSSSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHTTTSSCHHHHHHHHHHHHHHHTSCHHHHHH T ss_pred CcHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 34555666666667778888999999887644443334444567777888887777788888999998888644433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ....++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 168 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 224 (243) T 5MFI_B 168 LIEAGALSPLVKLLD-DASEEVIQEAVWAIANIASGNNEQIQKLEEAGAEPALEKLQS 224 (243) T ss_dssp HHHTTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHGGG T ss_pred HHHCCcHHHHHHHcc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHhc Confidence 334456777777776 5567888889999999886332 2222333 56666666654 No 166 >5MFJ_B YIII(Dq.V2)4CqI, (KR)5; Designed armadillo repeat protein, peptide; 1.53A {synthetic construct} Probab=96.43 E-value=9.2e-06 Score=73.31 Aligned_cols=135 Identities=19% Similarity=0.216 Sum_probs=90.0 Template_Neff=13.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.+..++..++.++.++....+.....+...++++.+...+.+.+..++..++.++..++......... T Consensus 88 ~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~ 167 (243) T 5MFJ_B 88 GALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQK 167 (243) T ss_dssp TCHHHHHHHHHHSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHTTTSSCHHHHHHHHHHHHHHHTSCHHHHHH T ss_pred CcHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 34555666666667778888999999887644443334444567777888887777788888999998888644433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ....++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 168 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 224 (243) T 5MFJ_B 168 LIEAGALSPLVKLLD-DASEEVIQEAVWAIANIASGNNEQIQKLEEAGAEPALEKLQS 224 (243) T ss_dssp HHHTTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHTSS T ss_pred HHHCCcHHHHHHHcc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHhc Confidence 334456777777776 5567888889999999886332 2222333 56666666654 No 167 >4MFU_A Beta-catenin-like protein 1; ARM repeats, GENE REGULATION; 2.744A {Homo sapiens} Probab=96.43 E-value=1.1e-05 Score=87.33 Aligned_cols=182 Identities=12% Similarity=0.061 Sum_probs=127.6 Template_Neff=8.700 Q NP_000290.2 539 GSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLM----SSGMSQLIGLKEKGLPQIARLLQS------GN 608 (747) Q Consensus 539 ~~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~----s~~~~~~llie~giI~~Ll~LL~s------~d 608 (747) ....+++.|+++.|+.+|. +++..+...++.+|.+++...... ........+.+.++++.|+.+|.. .+ T Consensus 60 ~~~~lv~~g~i~~Lv~LL~-~~n~~i~~~a~~~L~~Lt~~~~~~~~~~~~~~~~~~l~~~g~l~~Lv~~L~~~~e~~~~d 138 (490) T 4MFU_A 60 LYHLLVELNAVQSLLGLLG-HDNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDALVDGQVVALLVQNLERLDESVKEE 138 (490) T ss_dssp CTHHHHHTTHHHHHHHHTS-CSSHHHHHHHHHHHHHHHHGGGSSCCCHHHHHHHHHHHHTTHHHHHHHHHHHCCTTCHHH T ss_pred HHHHHHHCChHHHHHHHhC-CCCHHHHHHHHHHHHHHcCcccccCChhhHHHHHHHHHhCCHHHHHHHHHHhccccccch Confidence 3455678899999999998 466778888999999998643200 000013344577889999998875 55 Q NP_000290.2 609 SDVVRSGASLLSNMSRH-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLN 686 (747) Q Consensus 609 ~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~ 686 (747) ...+..++.+|.+|+.. +.. ..+...++++.|+.++.... ....++..++.+|.+|+..++..+..+.+.++++ T Consensus 139 ~~~~~~al~~L~nL~~~~~~~~~~i~~~~~l~~Ll~~L~~~~----~~~~~k~~a~~~L~~L~~~~~~~~~~l~~~g~i~ 214 (490) T 4MFU_A 139 ADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM----PFDANKLYCSEVLAILLQDNDENRELLGELDGID 214 (490) T ss_dssp HHHHHHHHHHHHHHHHHSTTHHHHHCCCCCHHHHHHHHHCCS----CCCHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHH T ss_pred HHHHHHHHHHHHHHhccCHHHHHHHHHCCHHHHHHHHHHcCC----CCHHHHHHHHHHHHHHHcCCHHHHHHHHhCchHH Confidence 67888999999999976 333 33445678888988887620 1367788999999999986566667777778899 Q NP_000290.2 687 NIINLCRS-----SA---SPKAAEAARLLLSDMWSSKELQGVLRQQG 725 (747) Q Consensus 687 ~Ll~LL~s-----~~---d~eVr~aAL~aLsnL~~~~~~~~~~~~~~ 725 (747) .|+.++.. +. .......++.+|.+++...+.+..+.+.| T Consensus 215 ~Ll~lL~~~~~~d~~~~~~~e~~en~~~aL~~L~~~~~~~~~f~~~~ 261 (490) T 4MFU_A 215 VLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGE 261 (490) T ss_dssp HHHHHHHTTSSSCCSSHHHHHHHHHHHHHHHHHHHSTHHHHHHHHTT T ss_pred HHHHHHHhhhhcCCCCHHHHHHHHHHHHHHHHHhCCHHHHHHHHHCC Confidence 99998851 11 12344556889999887776655554443 No 168 >5AEI_B DESIGNED ARMADILLO REPEAT PROTEIN YIIIM5AII; DE NOVO PROTEIN, PROTEIN-PEPTIDE COMPLEX; HET: CA, ACT; 1.83A {SYNTHETIC CONSTRUCT} Probab=96.41 E-value=1e-05 Score=74.57 Aligned_cols=134 Identities=26% Similarity=0.306 Sum_probs=85.5 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.+..++..++.++..++.......... T Consensus 89 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 168 (286) T 5AEI_B 89 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 168 (286) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHhCCHHHHHHHHccCCCHHHHHHHHHHHHHHHcCChHHHHHH Confidence 44556666666677788888999888876533333333344567777777777777888889999988876543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 169 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 224 (286) T 5AEI_B 169 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLS 224 (286) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHcChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHcc Confidence 33456677777775 4566778888888888876422 2222222 45565655554 No 169 >4PLS_B Arm00010; PEPTIDE BINDING PROTEIN, designed armadillo; HET: CA; 2.35A {synthetic construct} Probab=96.39 E-value=1.1e-05 Score=74.12 Aligned_cols=111 Identities=25% Similarity=0.289 Sum_probs=73.2 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..++...+.....+...++++.+...+.+.++.++..++.++..++...+.....+ T Consensus 170 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 249 (281) T 4PLS_B 170 ALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQKQAV 249 (281) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred hHHHHHHHhcCCcHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHccCCCHHHHHHHHHHHHHHHcCChhHHHHH Confidence 45556666666677888889999988876544333333444577777787877777888899999998885544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNL 357 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnL 357 (747) ...++++.+...+. ..++.++..++.++..+ T Consensus 250 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l 280 (281) T 4PLS_B 250 KEAGAEPALEQLQS-SPNEKIQKEAQEALEKI 280 (281) T ss_dssp HTTTHHHHHHTTTS-CSCHHHHHHHHHHHHHC T ss_pred HHCChHHHHHHHhc-CCCHHHHHHHHHHHHhh Confidence 33356666666665 45666777777666554 No 170 >4HM9_A Beta-catenin-like protein 1; all alpha-helical, armadillo repeats, PROTEIN; 3.1001A {Homo sapiens} Probab=96.38 E-value=1.4e-05 Score=88.57 Aligned_cols=181 Identities=12% Similarity=0.075 Sum_probs=128.1 Template_Neff=8.100 Q NP_000290.2 539 GSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSS---G--MSQLIGLKEKGLPQIARLLQS------G 607 (747) Q Consensus 539 ~~~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~---~--~~~~llie~giI~~Ll~LL~s------~ 607 (747) ....+++.|+++.|+.+|. +.+..++..++.+|.+|+..... .. . .....+.+.++++.|+.+|.. . T Consensus 138 ~~~~lv~~g~i~~Lv~LL~-~~n~di~~~a~~~L~~Lt~~~~~-~~~~~~~~~l~~~l~e~g~l~~Lv~~L~~l~e~~~~ 215 (568) T 4HM9_A 138 LYHLLVELNAVQSLLGLLG-HDNTDVSIAVVDLLQELTDIDTL-HESEEGAEVLIDALVDGQVVALLVQNLERLDESVKE 215 (568) T ss_dssp GHHHHHHTTHHHHHHHGGG-CSSHHHHHHHHHHHHHHTCHHHH-TTCHHHHHHHHHHHHHTTHHHHHHHHHTTCCTTSHH T ss_pred HHHHHHHCChHHHHHHHhC-CCCHHHHHHHHHHHHHHhCCccc-cCChhhHHHHHHHHHhCCHHHHHHHHHhcccccccc Confidence 4455678899999999998 46678888999999999864320 00 0 013344567889999998876 5 Q NP_000290.2 608 NSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSML 685 (747) Q Consensus 608 d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL 685 (747) +...+..++.+|.+|+.. +.. ..+...++++.|+.++.... .....+..|+.+|.+|+..++..+..+.+.+++ T Consensus 216 d~~~~~~al~iL~nL~~~~~~~~~~i~~~g~l~~Ll~lL~~~~----~~~~~k~~AaeiL~~L~~~~~~~r~~l~~~g~I 291 (568) T 4HM9_A 216 EADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM----PFDANKLYCSEVLAILLQDNDENRELLGELDGI 291 (568) T ss_dssp HHHHHHHHHHHHHHHHHHCGGGHHHHCCCCCHHHHHHHHHSSC----CCCHHHHHHHHHHHHHHTTCHHHHHHHHHTTHH T ss_pred hHHHHHHHHHHHHHHhccCHHHHHHHHHCCHHHHHHHHHHcCC----CCHHHHHHHHHHHHHHHcCCHHHHHHHHhCchH Confidence 567888999999999975 333 23445678888998887520 145678889999999998656677777778889 Q NP_000290.2 686 NNIINLCRS-----SA---SPKAAEAARLLLSDMWSSKELQGVLRQQG 725 (747) Q Consensus 686 ~~Ll~LL~s-----~~---d~eVr~aAL~aLsnL~~~~~~~~~~~~~~ 725 (747) +.|+.++.. .. .....+.++.+|..++...+.+..+...| T Consensus 292 ~~LL~lL~~y~~~d~~~~~e~e~~en~~~aL~~L~~~~~~r~~f~~~~ 339 (568) T 4HM9_A 292 DVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGE 339 (568) T ss_dssp HHHHHHHGGGTTSCCSSSHHHHHHHHHHHHHHHHTTSTHHHHHHHHTT T ss_pred HHHHHHHHhhhccCCCCHHHHHHHHHHHHHHHHHhCCHHHHHHHHHCC Confidence 999998851 11 12345566889999888776655444443 No 171 >3L6X_A Catenin delta-1, E-cadherin; p120, catenin, cadherin, E-cadherin, armadillo; HET: SO4; 2.4A {Homo sapiens} Probab=96.36 E-value=1.3e-05 Score=86.31 Aligned_cols=135 Identities=19% Similarity=0.251 Sum_probs=86.7 Template_Neff=11.000 Q NP_000290.2 246 TIPKAVQYLSS------QDEKYQAIGAYYIQHTCFQDE-------------------------SAKQQVYQLGGICKLVD 294 (747) Q Consensus 246 iL~~Ll~lL~s------sd~eVr~sAL~aLsnLs~~~~-------------------------~~~~~li~~~IL~~Ll~ 294 (747) +++.++.++.. .+..++..++.+|.+++.... .....+...++++.+.. T Consensus 236 ~v~~L~~~l~~~~~~~~~~~~~~~~a~~~L~~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~ 315 (584) T 3L6X_A 236 LVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGTSPARGYELLFQPEVVRIYIS 315 (584) T ss_dssp HHHHHHHHHHHHHHTTCCSCHHHHHHHHHHHHHHTTHHHHSTTCCC--------------CCCCGGGGGGSHHHHHHHHH T ss_pred HHHHHHHHHHHHhcCCCCChHHHHHHHHHHHHHHhhhhccChhHHHHHHhcCcCCCCCCCCChhhhhHhhChhHHHHHHH Confidence 34555565553 356677888888888875421 11223334567777777 Q NP_000290.2 295 LLRSP-NQNVQQAAAGALRNLVFRS----TTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA 369 (747) Q Consensus 295 lL~s~-d~eVr~~AL~aLs~La~~~----~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve 369 (747) ++... ++.++..++.+|.+++... ......+...++++.+..++. ..+..++..++.+|.+++........+.. T Consensus 316 ll~~~~~~~~~~~a~~~L~~L~~~~~~~~~~~~~~~~~~~~l~~L~~ll~-~~~~~v~~~a~~~L~~L~~~~~~~~~l~~ 394 (584) T 3L6X_A 316 LLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLT-NEHERVVKAASGALRNLAVDARNKELIGK 394 (584) T ss_dssp HHHHCCCHHHHHHHHHHHHHHHSSCSHHHHHHHHHHTSHHHHHHHHHGGG-CSCHHHHHHHHHHHHHHHTTCSCHHHHHH T ss_pred HHHcCCCHHHHHHHHHHHHHHhCCCccCCHHHHHHHHHcChHHHHHHHhc-CCCHHHHHHHHHHHHHHhcChHHHHHHHc Confidence 77765 7788889999999987642 222233334467778888886 56678888999999999876444333333 Q NP_000290.2 370 DALPVLADRVII 381 (747) Q Consensus 370 giLe~Lv~LL~~ 381 (747) ++++.|+.+|.. T Consensus 395 ~~l~~L~~~L~~ 406 (584) T 3L6X_A 395 HAIPNLVKNLPG 406 (584) T ss_dssp HHHHHHHHTSSS T ss_pred chHHHHHHcCCC Confidence 566666666643 No 172 >4U5L_A deltaIBB-importin-alpha1; TPX2, inhibitor, TRANSPORT PROTEIN; HET: 3D6; 2.53A {Mus musculus} Probab=96.35 E-value=1.2e-05 Score=78.71 Aligned_cols=134 Identities=17% Similarity=0.197 Sum_probs=87.3 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..++...+.....+...++++.+..++.+.++.++..++.++..++...+.....+ T Consensus 223 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 302 (426) T 4U5L_A 223 VVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQV 302 (426) T ss_dssp CHHHHHHHHTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTGGGGHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCccHHHHHHHHHHHHhcCCHHHHHHHhccchHHHHHHHhcCCChHHHHHHHHHHHHHhcCCHHHHHHH Confidence 45566666666777888889999998886544333344445677778888877778888899999998886544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD--ELKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~--~~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++... .....+.. ++++.|..++. T Consensus 303 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 359 (426) T 4U5L_A 303 VNHGLVPFLVGVLS-KADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLS 359 (426) T ss_dssp HHTTCHHHHHHHHH-SSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHTTCHHHHHHGGG T ss_pred HHCCHHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCCHHHHHHHHhCCcHHHHHHHhc Confidence 33456777777776 456677888888888887631 11122222 45555555544 No 173 >2JDQ_A IMPORTIN ALPHA-1 SUBUNIT, POLYMERASE BASIC; TRANSPORT, PB2 SUBUNIT, NUCLEAR PROTEIN; 2.2A {HOMO SAPIENS} Probab=96.34 E-value=1.3e-05 Score=79.63 Aligned_cols=366 Identities=18% Similarity=0.167 Sum_probs=218.3 Template_Neff=13.000 Q NP_000290.2 245 LTIPKAVQYLSS-QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~s-sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .+++.+...+.. .++.++..++.++..++.........+...++++.+...+.+.+..++..++.++..++........ T Consensus 64 ~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~ 143 (450) T 2JDQ_A 64 GVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRD 143 (450) T ss_dssp THHHHHHHHHTCTTCHHHHHHHHHHHHHHHSSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHH T ss_pred chHHHHHHHHccCCCHHHHHHHHHHHHHHhCCCcHHHHHHHHcChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCChHHHH Confidence 345556666655 5677888888888888765443333333456777888888777788899999999988765443333 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIA--DALPVLADRVIIPFSGWCDGNSNMSREVVDPE 401 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~Lve--giLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~ 401 (747) .+...++++.+...+....++.++..++.++..++........... ++++.+..++.. .+++ T Consensus 144 ~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~----------------~~~~ 207 (450) T 2JDQ_A 144 YVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFV----------------SDTD 207 (450) T ss_dssp HHHHTTCHHHHHHHTTSCCCHHHHHHHHHHHHHHHCCSSSCCCGGGTGGGHHHHHHHTTC----------------CCHH T ss_pred HHHHCCCHHHHHHHHhhccchhHHHHHHHHHHHHhcCCCCCchhhhhhhHHHHHHHHhcC----------------CCHH Confidence 3334566777777776333457888888999888765432222221 455556655543 1334 Q NP_000290.2 402 VFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHN 481 (747) Q Consensus 402 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 481 (747) +...+..+|..-... .+ ...+.. -..+++..|...+++ -+..-.+.++..|.+ T Consensus 208 ~~~~a~~~l~~l~~~------~~--------------~~~~~~-~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~ 260 (450) T 2JDQ_A 208 VLADACWALSYLSDG------PN--------------DKIQAV-IDAGVCRRLVELLMH------NDYKVVSPALRAVGN 260 (450) T ss_dssp HHHHHHHHHHHHTSS------SH--------------HHHHHH-HHTTTHHHHHHHTTC------SCHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHhcC------CH--------------HHHHHH-HHCCHHHHHHHHHcC------CCHHHHHHHHHHHHH Confidence 444444333221000 00 000000 012344444433321 011111222222222 Q NP_000290.2 482 LSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKK 561 (747) Q Consensus 482 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d 561 (747) +...- ......+.+.++++.++.++. +.+ T Consensus 261 l~~~~--------------------------------------------------~~~~~~~~~~~~~~~l~~~l~-~~~ 289 (450) T 2JDQ_A 261 IVTGD--------------------------------------------------DIQTQVILNCSALQSLLHLLS-SPK 289 (450) T ss_dssp HTTSC--------------------------------------------------HHHHHHHHTTTHHHHHHHHTT-CSS T ss_pred HhhCC--------------------------------------------------hHHHHHHhhcchHHHHHHHhc-CCC Confidence 22100 000112234567888888887 467 Q NP_000290.2 562 DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH--PLL-HRVMGNQVFP 638 (747) Q Consensus 562 ~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~--~e~-~~ll~~giI~ 638 (747) +.++..++.+|.+++..... ....+...++++.|..++.+.++.++..++.+|.+++.. +.. ..+...++++ T Consensus 290 ~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~ 364 (450) T 2JDQ_A 290 ESIKKEACWTISNITAGNRA-----QIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIK 364 (450) T ss_dssp HHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHTCHH T ss_pred HHHHHHHHHHHHHHhcCCHH-----HHHHHHhCCHHHHHHHHHhcCCHHHHHHHHHHHHHHhcCCCHHHHHHHHHCCcHH Confidence 78888999999999875332 223334567888899998888888999999999999876 222 2334456788 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK-----------QYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~-----------~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) .+..++.+ .++.++..++.+|.+++...+.... .+.+.+.++.+..++.+. ++.++..++.+ T Consensus 365 ~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~l~~l~~~~-~~~v~~~a~~~ 437 (450) T 2JDQ_A 365 PLCDLLTV------MDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQSHE-NQEIYQKAFDL 437 (450) T ss_dssp HHHHGGGS------SCHHHHHHHHHHHHHHHHHHHHHHHHSCSCCCHHHHHHHHHHCHHHHHHHHCHH-HHHHHHHHHHH T ss_pred HHHHHhhC------CCHHHHHHHHHHHHHHHHHhHHHHhhCCCCCCHHHHHHHHhccHHHHHHHHhCC-CHHHHHHHHHH Confidence 88888876 3678888999999999875332221 233445667776666665 77889999999 Q NP_000290.2 708 LSDMWSSKE 716 (747) Q Consensus 708 LsnL~~~~~ 716 (747) +.++....+ T Consensus 438 l~~~~~~~~ 446 (450) T 2JDQ_A 438 IEHYFGTED 446 (450) T ss_dssp HHHHHCCC- T ss_pred HHHHhcCcc Confidence 988876544 No 174 >3GQ2_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.18A {Bos taurus} Probab=96.33 E-value=1.5e-05 Score=88.20 Aligned_cols=169 Identities=12% Similarity=0.125 Sum_probs=105.6 Template_Neff=10.100 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSKK----DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNS-----DV-- 611 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~d----~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~-----eV-- 611 (747) +++.|+++.|+.++.. .. ..++..++.+|.+++..+.. ....+.+.++++.|..++...+. .. T Consensus 204 l~~~g~~~~L~~ll~~-~~~~~~~~v~~~al~~L~~L~~~~~~-----~~~~~~e~~~i~~L~~lL~~~~~~~~~~~~~~ 277 (651) T 3GQ2_A 204 VAFENAFERLLDIITE-EGNSDGGIVVEDCLILLQNLLKNNNS-----NQNFFKEGSYIQRMKPWFEVGDENSGWSAQKV 277 (651) T ss_dssp HHHTTHHHHHHHHHHH-TTGGGSHHHHHHHHHHHHHHHTTCHH-----HHHHHHHTTCGGGTGGGGCCCSSCCCCCHHHH T ss_pred HHhCChHHHHHHHHHH-hCCCCccHHHHHHHHHHHHHHhCCHH-----HHHHHHhcChHHHHHHHHhcCCccCCCchHHH Confidence 4577889999998873 32 25777899999999875432 34455567889999988874331 11 Q NP_000290.2 612 --VRSGASLLSNMSRH-------PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFS 681 (747) Q Consensus 612 --r~~AL~aLsnLa~~-------~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve 681 (747) ...++.++..++.. ... ..+...++++.|+.++.... .+..++..++.+|++++..++.....+.+ T Consensus 278 ~~~~~~~~il~~l~~~~~~~~~~~~~~~~l~~~g~l~~L~~ll~~~~----~~~~v~~~a~~~La~l~~~~~~~q~~~~~ 353 (651) T 3GQ2_A 278 TNLHLMLQLVRVLVSPNNPPGATSSCQKAMFQCGLLQQLCTILMATG----VPADILTETINTVSEVIRGCQVNQDYFAS 353 (651) T ss_dssp HHHHHHHHHHHHHHCTTSCHHHHHHHHHHHHHTTHHHHHHHHHHCSS----CCHHHHHHHHHHHHHHHTTCHHHHHHHHH T ss_pred HHHHHHHHHHHHHhCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHhcC----CCHHHHHHHHHHHHHHHhcCHHHHHHHHh Confidence 22334444444421 112 23356678888888886520 14578889999999998865555444444 Q NP_000290.2 682 S--------SMLNNIINLCRSS-ASPKAAEAARLLLSDMWSS-KELQGVL 721 (747) Q Consensus 682 ~--------giL~~Ll~LL~s~-~d~eVr~aAL~aLsnL~~~-~~~~~~~ 721 (747) . +.+..|+.++... .+..++..++.+|.+++.. .+.+..+ T Consensus 354 ~~~~~~~~~~~l~~Ll~~l~~~~~~~~~r~~al~~L~~~~~~~~~~~~~l 403 (651) T 3GQ2_A 354 VNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEI 403 (651) T ss_dssp CBCCSSSCCBHHHHHHHHHTCTTSCHHHHHHHHHHHHHHHTTCHHHHHHH T ss_pred CCCCCCCCchHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHhcCHHHHHHH Confidence 2 2355666665432 1567888999999666653 3334333 No 175 >3GRL_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.0A {Bos taurus} Probab=96.33 E-value=1.5e-05 Score=88.20 Aligned_cols=169 Identities=12% Similarity=0.125 Sum_probs=105.6 Template_Neff=10.100 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSKK----DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNS-----DV-- 611 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~d----~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~-----eV-- 611 (747) +++.|+++.|+.++.. .. ..++..++.+|.+++..+.. ....+.+.++++.|..++...+. .. T Consensus 204 l~~~g~~~~L~~ll~~-~~~~~~~~v~~~al~~L~~L~~~~~~-----~~~~~~e~~~i~~L~~lL~~~~~~~~~~~~~~ 277 (651) T 3GRL_A 204 VAFENAFERLLDIITE-EGNSDGGIVVEDCLILLQNLLKNNNS-----NQNFFKEGSYIQRMKPWFEVGDENSGWSAQKV 277 (651) T ss_dssp HHHTTHHHHHHHHHHH-HTGGGSHHHHHHHHHHHHHHHTTCHH-----HHHHHHHTTCGGGGGGGGCCCSCSSCCCHHHH T ss_pred HHhCChHHHHHHHHHH-hCCCCccHHHHHHHHHHHHHHhCCHH-----HHHHHHhcChHHHHHHHHhcCCccCCCchHHH Confidence 4577889999998873 32 25777899999999875432 34455567889999988874331 11 Q NP_000290.2 612 --VRSGASLLSNMSRH-------PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFS 681 (747) Q Consensus 612 --r~~AL~aLsnLa~~-------~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve 681 (747) ...++.++..++.. ... ..+...++++.|+.++.... .+..++..++.+|++++..++.....+.+ T Consensus 278 ~~~~~~~~il~~l~~~~~~~~~~~~~~~~l~~~g~l~~L~~ll~~~~----~~~~v~~~a~~~La~l~~~~~~~q~~~~~ 353 (651) T 3GRL_A 278 TNLHLMLQLVRVLVSPNNPPGATSSCQKAMFQCGLLQQLCTILMATG----VPADILTETINTVSEVIRGCQVNQDYFAS 353 (651) T ss_dssp HHHHHHHHHHHHHTCTTSCHHHHHHHHHHHHHTTHHHHHHHHHTCSS----CCHHHHHHHHHHHHHHHTTCHHHHHHHHH T ss_pred HHHHHHHHHHHHHhCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHhcC----CCHHHHHHHHHHHHHHHhcCHHHHHHHHh Confidence 22334444444421 112 23356678888888886520 14578889999999998865555444444 Q NP_000290.2 682 S--------SMLNNIINLCRSS-ASPKAAEAARLLLSDMWSS-KELQGVL 721 (747) Q Consensus 682 ~--------giL~~Ll~LL~s~-~d~eVr~aAL~aLsnL~~~-~~~~~~~ 721 (747) . +.+..|+.++... .+..++..++.+|.+++.. .+.+..+ T Consensus 354 ~~~~~~~~~~~l~~Ll~~l~~~~~~~~~r~~al~~L~~~~~~~~~~~~~l 403 (651) T 3GRL_A 354 VNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEI 403 (651) T ss_dssp CEESSSSCEEHHHHHHHHHTCTTSCHHHHHHHHHHHHHHHTTCHHHHHHH T ss_pred CCCCCCCCchHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHhcCHHHHHHH Confidence 2 2355666665432 1567888999999666653 3334333 No 176 >3TT9_A Plakophilin-2; CELL ADHESION; HET: GOL; 1.55A {Homo sapiens} Probab=96.31 E-value=1.5e-05 Score=72.85 Aligned_cols=113 Identities=18% Similarity=0.215 Sum_probs=69.5 Template_Neff=12.300 Q NP_000290.2 246 TIPKAVQYLS-SQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP---------------NQNVQQAAAG 309 (747) Q Consensus 246 iL~~Ll~lL~-ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~---------------d~eVr~~AL~ 309 (747) +++.++.++. ..+..++..++.++.+++... .....+...+++..+..++... +..++..++. T Consensus 95 ~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~-~~~~~~~~~~~~~~l~~ll~~~~~~~~~~~~~~~~~~~~~~~~~a~~ 173 (233) T 3TT9_A 95 GVPRLLQVLKQTRDLETKKQITGLLWNLSSND-KLKNLMITEALLTLTENIIIPFSGWPEGDYPKANGLLDFDIFYNVTG 173 (233) T ss_dssp HHHHHHHHHHHCCCHHHHHHHHHHHHHHHTSG-GGHHHHHHHHHHHHCCCCCHHHHCCCGGGCCCCCTTCCHHHHHHHHH T ss_pred cHHHHHHHHhhCCCHHHHHHHHHHHHHHccCH-HHHHHhhhhcHHHHHHHHHhhccCCCCCCCCcccCCCcHHHHHHHHH Confidence 4555666665 456778888999999987633 2233333344555555554322 4567778888 Q NP_000290.2 310 ALRNLVFRSTTNKLETRRQNG-IREAVSLLRRTG------NAEIQKQLTGLLWNLSST 360 (747) Q Consensus 310 aLs~La~~~~~~~~~ll~~~I-L~~Ll~lL~ss~------d~eVr~~AL~aLsnLas~ 360 (747) ++.+++...+.....+...+. ++.+..++. .. ++.++..++.+|.+++.. T Consensus 174 ~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~~~~L~~l~~~ 230 (233) T 3TT9_A 174 CLRNMSSAGADGRKAMRRCDGLIDSLVHYVR-GTIADYQPDDKATENCVCILHNLSYQ 230 (233) T ss_dssp HHHHHTTSCHHHHHHHHTSTTHHHHHHHHHH-HHHHTTCTTCHHHHHHHHHHHHHCCC T ss_pred HHHHHHhcCHHHHHHHHHcccHHHHHHHHHH-cccccCCCChHHHHHHHHHHHHhhhc Confidence 888887643333333433344 777777775 33 466777788888777653 No 177 >5D5K_C Importin subunit alpha-1, Poly [ADP-ribose]; PARP-2 NLS, PARP-2, poly(ADP-ribose)polymerase-2, Importin; 1.9A {Mus musculus} Probab=96.29 E-value=1.5e-05 Score=79.23 Aligned_cols=113 Identities=17% Similarity=0.142 Sum_probs=78.1 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS-TTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~-~~~~~~ 324 (747) +++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.++.++..++.++..++... ...... T Consensus 273 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 352 (466) T 5D5K_C 273 ALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVY 352 (466) T ss_dssp GGGGHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTCHHHHHHHHHSSCHHHHHHHHHHHHHHHHHSCHHHHHH T ss_pred hhHhHHHHhhCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHH Confidence 4555666666667788888999998887654433333444467777888887777788889999998887642 222222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) +...++++.+...+. ..++.++..++.++..++. T Consensus 353 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~ 386 (466) T 5D5K_C 353 LVHCGIIEPLMNLLS-AKDTKIIQVILDAISNIFQ 386 (466) T ss_dssp HHHTTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHH T ss_pred HHhCCcHHHHHHHhh-cCCHHHHHHHHHHHHHHHH Confidence 333346777777776 5567788889999988876 No 178 >4UAF_B Importin alpha 1 import receptor; importin karyopherin complex NLS, PROTEIN; HET: PO4; 1.698A {Mus musculus} Probab=96.28 E-value=1.6e-05 Score=79.14 Aligned_cols=113 Identities=17% Similarity=0.142 Sum_probs=78.0 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS-TTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~-~~~~~~ 324 (747) +++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.++.++..++.++..++... ...... T Consensus 273 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 352 (466) T 4UAF_B 273 ALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVY 352 (466) T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHH Confidence 4555666666667788888999999887654433333444467777888887777788889999998887642 222222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) +...++++.+...+. ..++.++..++.++..++. T Consensus 353 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~ 386 (466) T 4UAF_B 353 LVHCGIIEPLMNLLS-AKDTKIIQVILDAISNIFQ 386 (466) T ss_pred HHhCCcHHHHHHHhh-cCCHHHHHHHHHHHHHHHH Confidence 333346777777776 5567788889999988876 No 179 >2JDQ_A IMPORTIN ALPHA-1 SUBUNIT, POLYMERASE BASIC; TRANSPORT, PB2 SUBUNIT, NUCLEAR PROTEIN; 2.2A {HOMO SAPIENS} Probab=96.23 E-value=1.8e-05 Score=78.41 Aligned_cols=134 Identities=18% Similarity=0.203 Sum_probs=87.8 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++..++.........+...++++.+...+.+.++.++..++.++..++.......... T Consensus 235 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 314 (450) T 2JDQ_A 235 VCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTV 314 (450) T ss_dssp THHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHTTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHHcCCCHHHHHHHHHHHHHHhhCChHHHHHHhhcchHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 45566666666677888889999998887544333333334677778888877777888899999998876544333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST--DELKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~--~~~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.. ......+.. ++++.|..++. T Consensus 315 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~ 371 (450) T 2JDQ_A 315 IDANIFPALISILQ-TAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLT 371 (450) T ss_dssp HHTTHHHHHHHHHH-HSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHTCHHHHHHGGG T ss_pred HhCCHHHHHHHHHh-cCCHHHHHHHHHHHHHHhcCCCHHHHHHHHHCCcHHHHHHHhh Confidence 34457777777776 55677888888888888764 222222222 45555555554 No 180 >3IFQ_A plakoglobin, E-cadherin; armadillo repeat, Cardiomyopathy, Cell adhesion; HET: SO4; 2.8A {Homo sapiens} Probab=96.23 E-value=1.8e-05 Score=80.55 Aligned_cols=367 Identities=18% Similarity=0.234 Sum_probs=218.1 Template_Neff=13.100 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP-NQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~-d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .+++.+...+.+.++.++..++.++..+....+.....+...++++.+...+... +..++..++.++..+..... ... T Consensus 145 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~-~~~ 223 (553) T 3IFQ_A 145 DGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPS-NKP 223 (553) T ss_dssp TGGGGTGGGGGSSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHTTSTT-HHH T ss_pred CHHHHHHHHHhcCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHHhcCCcHHHHHHHHHHHHHHhCCcc-hHH Confidence 4556666667667778888899999988764443333333445677777777654 56778888888888876322 222 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVF 403 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~ 403 (747) .+...++++.+...+. ..++.++..++.++..++....... ...++++.+..++.. .++++. T Consensus 224 ~~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~-~~~~~~~~l~~~l~~----------------~~~~~~ 285 (553) T 3IFQ_A 224 AIVEAGGMQALGKHLT-SNSPRLVQNCLWTLRNLSDVATKQE-GLESVLKILVNQLSV----------------DDVNVL 285 (553) T ss_dssp HHHHTTHHHHHHGGGG-SSCHHHHHHHHHHHHHHHTTCTTCS-CCHHHHHHHHTTTTC----------------CCHHHH T ss_pred HHHHCchHHHHHHHHh-cCCHHHHHHHHHHHHHhCChhHHHH-HHHHHHHHHHHHcCC----------------CCHHHH Confidence 3333456777777776 5567788888888888876432211 112455555555532 133333 Q NP_000290.2 404 FNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLS 483 (747) Q Consensus 404 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 483 (747) ..+..++..-.. ..+ ...+.+. -.+.++.++..+.. ..-+..-.+.+..+|.++. T Consensus 286 ~~a~~~l~~l~~------~~~--------------~~~~~~~-~~~~~~~l~~~l~~----~~~~~~~~~~a~~~l~~l~ 340 (553) T 3IFQ_A 286 TCATGTLSNLTC------NNS--------------KNKTLVT-QNSGVEALIHAILR----AGDKDDITEPAVCALRHLT 340 (553) T ss_dssp HHHHHHHHHHTT------TCH--------------HHHHHHT-TTTHHHHHHHHHHH----HTTCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHHc------CCH--------------HHHHHHH-HccHHHHHHHHHHH----cCCChHhHHHHHHHHHHHh Confidence 333333321100 000 0000000 01233333332211 0011222333344444443 Q NP_000290.2 484 YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDA 563 (747) Q Consensus 484 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~e 563 (747) ...+.. ......+...++++.++.++....++. T Consensus 341 ~~~~~~-----------------------------------------------~~~~~~~~~~~~~~~l~~~l~~~~~~~ 373 (553) T 3IFQ_A 341 SRHPEA-----------------------------------------------EMAQNSVRLNYGIPAIVKLLNQPNQWP 373 (553) T ss_dssp SSSTTH-----------------------------------------------HHHHHHHHTTTHHHHHHHGGGCTTCHH T ss_pred cCCChH-----------------------------------------------HHHHHHHHHcchHHHHHHHHcCCCChH Confidence 211100 000112234566788888887322367 Q NP_000290.2 564 TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNS---------------------DVVRSGASLLSNM 622 (747) Q Consensus 564 Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~---------------------eVr~~AL~aLsnL 622 (747) ++..++.+|.+++.... ....+...++++.|..++.+.+. .++..++.+|.++ T Consensus 374 ~~~~a~~~l~~l~~~~~------~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l 447 (553) T 3IFQ_A 374 LVKATIGLIRNLALCPA------NHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHIL 447 (553) T ss_dssp HHHHHHHHHHHHTTSGG------GHHHHHHTTHHHHHHHHHHHHHHHHHHHHHTTCCCTTCSSCCHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHhcCcc------cHHHHHHccHHHHHHHHHHHcCcchhHHHhhcccCccccCCCHHHHHHHHHHHHHHH Confidence 78889999999887532 12333456788888888876554 7888899999998 Q NP_000290.2 623 SRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAA 701 (747) Q Consensus 623 a~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr 701 (747) +..... ......++++.+..++.+ .++.++..++.+|.+++.. +.....+.+.++++.|..++.+. ++.++ T Consensus 448 ~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~-~~~~~~~~~~~~~~~l~~~l~~~-~~~v~ 519 (553) T 3IFQ_A 448 ARDPMNRMEIFRLNTIPLFVQLLYS------SVENIQRVAAGVLCELAQD-KEAADAIDAEGASAPLMELLHSR-NEGTA 519 (553) T ss_dssp TTSHHHHHHHHHTTCHHHHHHHTTC------SCHHHHHHHHHHHHHHTTS-HHHHHHHHHTTTHHHHHHHTTCS-SHHHH T ss_pred hcChhhHHHHHHcCChHHHHHHHhC------CCHHHHHHHHHHHHHHHcC-HHHHHHHHHCCcHHHHHHHHhCC-CHHHH Confidence 875333 233445677888888775 3678899999999999875 44555555667888898888877 78899 Q NP_000290.2 702 EAARLLLSDMWSSKE 716 (747) Q Consensus 702 ~aAL~aLsnL~~~~~ 716 (747) ..++.+|.+++...+ T Consensus 520 ~~a~~~l~~l~~~~~ 534 (553) T 3IFQ_A 520 TYAAAVLFRISEDKN 534 (553) T ss_dssp HHHHHHHHHTTSTTC T ss_pred HHHHHHHHHHHcccC Confidence 999999999996543 No 181 >4BQK_A IMPORTIN SUBUNIT ALPHA-1A, T-DNA BORDER; TRANSPORT PROTEIN, HYDROLASE, NUCLEAR LOCALIZATION; HET: PEG; 1.997A {ORYZA SATIVA} Probab=96.23 E-value=1.9e-05 Score=78.53 Aligned_cols=116 Identities=19% Similarity=0.202 Sum_probs=77.5 Template_Neff=13.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.+..++..++.++..+....+.....+...++++.+...+.+.+..++..++.++..++......... T Consensus 172 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 251 (456) T 4BQK_A 172 PALPALARLIHSNDEEVLTDACWALSYLSDGTNDKIQAVIEAGVCPRLVELLLHPSPSVLIPALRTVGNIVTGDDAQTQC 251 (456) T ss_dssp THHHHHHHHTTCCCHHHHHHHHHHHHHHTSSSHHHHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCChHHHHHHHHCChHHHHHHHHhCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 34556666666677788888999998887654433333334466777777777777788888999998887654333233 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) +...++++.+...+....++.++..++.++..++.. T Consensus 252 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~ 287 (456) T 4BQK_A 252 IIDHQALPCLLSLLTQNLKKSIKKEACWTISNITAG 287 (456) T ss_dssp HHTTTHHHHHHHHHHSCCCHHHHHHHHHHHHHHHTS T ss_pred HHHCChHHHHHHHHHcCCCHHHHHHHHHHHHHHhcC Confidence 333456677777775222566777888888887754 No 182 >4U5L_A deltaIBB-importin-alpha1; TPX2, inhibitor, TRANSPORT PROTEIN; HET: 3D6; 2.53A {Mus musculus} Probab=96.17 E-value=2.2e-05 Score=76.74 Aligned_cols=115 Identities=21% Similarity=0.205 Sum_probs=78.3 Template_Neff=13.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.++.++..++.++..++...+..... T Consensus 180 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 259 (426) T 4U5L_A 180 QILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQK 259 (426) T ss_dssp HHHHHHHHHTTSSCHHHHHHHHHHHHHHTSSCHHHHHHHHTTTCHHHHHHHHTCSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred HHHHHHHHHHhCCCHHHHHHHHHHHHHHhhCCcHHHHHHhhcChHHHHHHHhcCCCccHHHHHHHHHHHHhcCCHHHHHH Confidence 45556666666677788888999998887654433333344457777888887777788889999998888654333333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) +...++++.+...+. +.++.++..++.++..++.. T Consensus 260 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~ 294 (426) T 4U5L_A 260 VIDAGALAVFPSLLT-NPKTNIQKEATWTMSNITAG 294 (426) T ss_dssp HHHTTGGGGHHHHTT-CSSHHHHHHHHHHHHHHTTS T ss_pred HhccchHHHHHHHhc-CCChHHHHHHHHHHHHHhcC Confidence 334456677777775 45667777777777777653 No 183 >4BPL_A IMPORTIN SUBUNIT ALPHA-1A, NUCLEOPLASMIN NLS; TRANSPORT PROTEIN, NUCLEAR IMPORT, NUCLEAR; 2.3A {ORYZA SATIVA} Probab=96.16 E-value=2.3e-05 Score=77.77 Aligned_cols=135 Identities=18% Similarity=0.197 Sum_probs=84.9 Template_Neff=13.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.+..++..++.++..+....+.....+...++++.+...+.+.+..++..++.++..++......... T Consensus 170 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 249 (454) T 4BPL_A 170 PALPALARLIHSNDEEVLTDACWALSYLSDGTNDKIQAVIEAGVCPRLVELLLHPSPSVLIPALRTVGNIVTGDDAQTQC 249 (454) T ss_dssp THHHHHHHHTTCCCHHHHHHHHHHHHHHTSSCHHHHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred HHHHHHHHHHhCCCHHHHHHHHHHHHHHhcCChHHHHHHHHCCcHHHHHHHhhCCChHHHHHHHHHHHHHhcCCHHHHHH Confidence 34556666666677788888999998887654433333334456777777777777788888999998887654333233 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRV 379 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL 379 (747) +...++++.+...+....++.++..++.++..++..... ...+.. ++++.|..++ T Consensus 250 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l 306 (454) T 4BPL_A 250 IIDHQALPCLLSLLTQNLKKSIKKEACWTISNITAGNKDQIQAVINAGIIGPLVNLL 306 (454) T ss_dssp HHTTTHHHHHHHHHHSSCCHHHHHHHHHHHHHHHTSCHHHHHHHHHHTCHHHHHHHH T ss_pred HHHCChHHHHHHHHHhcCCHHHHHHHHHHHHHHhcCCHHHHHHHHhCCcHHHHHHHh Confidence 333456677777775222567778888888887754321 112222 4555555544 No 184 >4MZ6_E Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Importin; ARM repeat, protein transport, Importin; 1.88A {Mus musculus} Probab=96.12 E-value=2.6e-05 Score=79.03 Aligned_cols=113 Identities=17% Similarity=0.142 Sum_probs=77.9 Template_Neff=12.800 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS-TTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~-~~~~~~ 324 (747) +++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.++.++..++.++..++... ...... T Consensus 317 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 396 (509) T 4MZ6_E 317 ALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVY 396 (509) T ss_dssp GGGGHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHHHSSCHHHHHHHHHHHHHHHHHSCHHHHHH T ss_pred hHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHH Confidence 4455566666667788888999998887654433333444467777888887777788889999998887642 222223 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) +...++++.+...+. ..++.++..++.++..++. T Consensus 397 ~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~ 430 (509) T 4MZ6_E 397 LVHCGIIEPLMNLLS-AKDTKIIQVILDAISNIFQ 430 (509) T ss_dssp HHHTTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHH T ss_pred HHhCCCHHHHHHHHh-CCCHHHHHHHHHHHHHHHH Confidence 333346777777776 5567788889999988876 No 185 >5UMZ_B Importin subunit alpha-1, TNRC6A; mRNA decay, miRNA ARM repeat; HET: GOL; 1.9A {Mus musculus} Probab=96.12 E-value=2.6e-05 Score=79.03 Aligned_cols=113 Identities=17% Similarity=0.142 Sum_probs=77.9 Template_Neff=12.800 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS-TTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~-~~~~~~ 324 (747) +++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.++.++..++.++..++... ...... T Consensus 317 ~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 396 (509) T 5UMZ_B 317 ALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVY 396 (509) T ss_dssp GGGGHHHHTTCSSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHHHSSCHHHHHHHHHHHHHHHHHSCHHHHHH T ss_pred hHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCCHHHHHH Confidence 4455566666667788888999998887654433333444467777888887777788889999998887642 222223 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) +...++++.+...+. ..++.++..++.++..++. T Consensus 397 ~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~ 430 (509) T 5UMZ_B 397 LVHCGIIEPLMNLLS-AKDTKIIQVILDAISNIFQ 430 (509) T ss_dssp HHHTTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHH T ss_pred HHhCCCHHHHHHHHh-CCCHHHHHHHHHHHHHHHH Confidence 333346777777776 5567788889999988876 No 186 >4E4V_A Importin subunit alpha-2; armadillo repeat, karyopherin, importin, nuclear; HET: GOL, DTT; 2.5283A {Homo sapiens} Probab=96.12 E-value=2.7e-05 Score=78.66 Aligned_cols=113 Identities=17% Similarity=0.130 Sum_probs=78.1 Template_Neff=12.700 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRST-TNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~-~~~~~ 324 (747) +++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.++.++..++.++..++.... ..... T Consensus 292 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 371 (485) T 4E4V_A 292 ALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVY 371 (485) T ss_dssp GGGGHHHHHTCSSHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHHHHHSCHHHHHHHHHHHHHHHHHSCHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHcCCCHHHHHHHHHCCHHHHHHHHHhcCCHHHHHHHHHHHHHHHhcCCHHHHHH Confidence 45556666666677888889999998876544333334444677778888877777888889999988876422 22222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) +...++++.+...+. ..++.++..++.++..++. T Consensus 372 ~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~ 405 (485) T 4E4V_A 372 LVHCGIIEPLMNLLT-AKDTKIILVILDAISNIFQ 405 (485) T ss_dssp HHHTTCHHHHHHGGG-CSCHHHHHHHHHHHHHHHH T ss_pred HHhCCcHHHHHHHhh-cCCHHHHHHHHHHHHHHHH Confidence 333346777777776 5567788889999988886 No 187 >3GQ2_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.18A {Bos taurus} Probab=96.07 E-value=3.4e-05 Score=85.21 Aligned_cols=176 Identities=12% Similarity=0.192 Sum_probs=126.8 Template_Neff=10.100 Q NP_000290.2 543 LYHSDAIRTYLNLMGKS-KKDATLEACAGALQNLTASKGLMSSG--------------MSQLIGL-KEKGLPQIARLLQS 606 (747) Q Consensus 543 lve~G~I~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s~~~s~~--------------~~~~lli-e~giI~~Ll~LL~s 606 (747) ++..++++.|+.+|... .+..++..++.+|.+++...+. .. .....+. +.+.++.|+.++.+ T Consensus 56 ~v~~~~l~~Li~~L~~~~~d~~~~~~al~~L~~l~~~~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~Ll~ll~~ 133 (651) T 3GQ2_A 56 EVGIQAMEHLIHVLQTDRSDSEIIGYALDTLYNIISNDEE--EEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEE 133 (651) T ss_dssp HHHHHHHHHHHHHHTTCTTCHHHHHHHHHHHHHHHCCSSS--CC----------CHHHHHHHHHHTSHHHHHTHHHHTTC T ss_pred HHHccHHHHHHHHHhcCCCCHHHHHHHHHHHHHHhCCCCh--HhhhhcccccchHHHHHHHHHHHhcCchHHHHHHHccC Confidence 46778999999999731 3567788899999998864321 00 0012223 57888999999888 Q NP_000290.2 607 GNSDVVRSGASLLSNMSRHP--LLH-RVM-GNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSS 682 (747) Q Consensus 607 ~d~eVr~~AL~aLsnLa~~~--e~~-~ll-~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~ 682 (747) .++.++..++++|.+++... ... .++ ..++++.|+.+|.+ .+..++..++.+|.+++..+++....+... T Consensus 134 ~~~~~~~~al~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~~------~~~~i~~~a~~~L~~l~~~~~~~~~~l~~~ 207 (651) T 3GQ2_A 134 FDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLAD------SREVIRNDGVLLLQALTRSNGAIQKIVAFE 207 (651) T ss_dssp CCHHHHHHHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHGGGGGC------SSHHHHHHHHHHHHHHHTTCHHHHHHHHHT T ss_pred CCHHHHHHHHHHHHHHHHhccHHHHHHHHhCccHHHHHHHHhcC------CCHHHHHHHHHHHHHHhCCCHHHHHHHHhC Confidence 88889999999999998773 222 233 45678889998876 367888999999999998555666666677 Q NP_000290.2 683 SMLNNIINLCRSSAS---PKAAEAARLLLSDMWSSK-ELQGVLRQQGF 726 (747) Q Consensus 683 giL~~Ll~LL~s~~d---~eVr~aAL~aLsnL~~~~-~~~~~~~~~~~ 726 (747) ++++.|+.++..... ..++..++.+|.+|+... ..+..++..|+ T Consensus 208 g~~~~L~~ll~~~~~~~~~~v~~~al~~L~~L~~~~~~~~~~~~e~~~ 255 (651) T 3GQ2_A 208 NAFERLLDIITEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSY 255 (651) T ss_dssp THHHHHHHHHHHTTGGGSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTC T ss_pred ChHHHHHHHHHHhCCCCccHHHHHHHHHHHHHHhCCHHHHHHHHhcCh Confidence 889999998875411 257888999999988644 44555555554 No 188 >3GRL_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.0A {Bos taurus} Probab=96.07 E-value=3.4e-05 Score=85.21 Aligned_cols=176 Identities=12% Similarity=0.192 Sum_probs=126.4 Template_Neff=10.100 Q NP_000290.2 543 LYHSDAIRTYLNLMGKS-KKDATLEACAGALQNLTASKGLMSSG--------------MSQLIGL-KEKGLPQIARLLQS 606 (747) Q Consensus 543 lve~G~I~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s~~~s~~--------------~~~~lli-e~giI~~Ll~LL~s 606 (747) ++..++++.|+.+|... .+..++..++.+|.+++...+. .. .....+. +.+.++.|+.++.+ T Consensus 56 ~v~~~~l~~Li~~L~~~~~d~~~~~~al~~L~~l~~~~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~Ll~ll~~ 133 (651) T 3GRL_A 56 EVGIQAMEHLIHVLQTDRSDSEIIGYALDTLYNIISNDEE--EEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEE 133 (651) T ss_dssp HCCCCCHHHHHHHHHSCTTCHHHHHHHHHHHHHHHCCC----------------CHHHHHHHHHHHSTHHHHHHHHHTTC T ss_pred HHHccHHHHHHHHHhcCCCCHHHHHHHHHHHHHHhCCCCh--HhhhhcccccchHHHHHHHHHHHhcCchHHHHHHHccC Confidence 46778999999999731 3567788899999998864321 00 0012223 57888999999888 Q NP_000290.2 607 GNSDVVRSGASLLSNMSRHP--LLH-RVM-GNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSS 682 (747) Q Consensus 607 ~d~eVr~~AL~aLsnLa~~~--e~~-~ll-~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~ 682 (747) .++.++..++++|.+++... ... .++ ..++++.|+.+|.+ .+..++..++.+|.+++..+++....+... T Consensus 134 ~~~~~~~~al~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~~------~~~~i~~~a~~~L~~l~~~~~~~~~~l~~~ 207 (651) T 3GRL_A 134 FDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLAD------SREVIRNDGVLLLQALTRSNGAIQKIVAFE 207 (651) T ss_dssp CCHHHHHHHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHHGGGGC------SSHHHHHHHHHHHHHHHTTCHHHHHHHHHT T ss_pred CCHHHHHHHHHHHHHHHHhccHHHHHHHHhCccHHHHHHHHhcC------CCHHHHHHHHHHHHHHhCCCHHHHHHHHhC Confidence 88889999999999998773 222 233 45678889998876 367888999999999998555666666677 Q NP_000290.2 683 SMLNNIINLCRSSAS---PKAAEAARLLLSDMWSSK-ELQGVLRQQGF 726 (747) Q Consensus 683 giL~~Ll~LL~s~~d---~eVr~aAL~aLsnL~~~~-~~~~~~~~~~~ 726 (747) ++++.|+.++..... ..++..++.+|.+|+... ..+..++..|+ T Consensus 208 g~~~~L~~ll~~~~~~~~~~v~~~al~~L~~L~~~~~~~~~~~~e~~~ 255 (651) T 3GRL_A 208 NAFERLLDIITEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSY 255 (651) T ss_dssp THHHHHHHHHHHHTGGGSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTC T ss_pred ChHHHHHHHHHHhCCCCccHHHHHHHHHHHHHHhCCHHHHHHHHhcCh Confidence 889999998875411 257888999999988644 44555555554 No 189 >4V3Q_A YIII_M4_AII; DE NOVO PROTEIN, PROTEIN ENGINEERING; HET: GOL, CA; 1.8A {SYNTHETIC CONSTRUCT} Probab=96.03 E-value=3.4e-05 Score=69.70 Aligned_cols=112 Identities=26% Similarity=0.317 Sum_probs=74.8 Template_Neff=12.900 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++.+++...+.....+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 135 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 214 (247) T 4V3Q_A 135 ALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQKQAV 214 (247) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666677788888899988876543333333344567777777777777888889999988886543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++++.+..++. ..++.++..++.++..+. T Consensus 215 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~ 246 (247) T 4V3Q_A 215 KEAGALEKLEQLQS-HENEKIQKEAQEALEKLQ 246 (247) T ss_dssp HHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHT T ss_pred HHcCHHHHHHHHHh-CChHHHHHHHHHHHHHHc Confidence 33456677777775 456677777777776653 No 190 >4TNM_A Importin-alpha3 / MOS6; armadillo repeat; 2.9A {Arabidopsis thaliana} Probab=96.03 E-value=3.5e-05 Score=79.51 Aligned_cols=136 Identities=16% Similarity=0.178 Sum_probs=85.8 Template_Neff=12.300 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..++.........+...++++.+...+.+.++.++..++.++..++......... T Consensus 245 ~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 324 (531) T 4TNM_A 245 PALPVLERLVQSMDEEVLTDACWALSYLSDNSNDKIQAVIEAGVVPRLIQLLGHSSPSVLIPALRTIGNIVTGDDLQTQM 324 (531) T ss_pred chHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCChHHHHHHHHhCCCHHHHHHHHHHHHHHHCCCHHHHHH Confidence 34555666666667778888889988887654433333344467777778787777788888999998887654333223 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVI 380 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~ 380 (747) ....++++.+..++....++.++..++.++..++... .....+.. ++++.|..++. T Consensus 325 ~~~~~~~~~l~~~l~~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 382 (531) T 4TNM_A 325 VLDQQALPCLLNLLKNNYKKSIKKEACWTISNITAGNADQIQAVIDAGIIQSLVWVLQ 382 (531) T ss_pred HHHCCcHHHHHHHhcCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCcHHHHHHHhc Confidence 3333566777777752235677888888888887643 22222222 45555555553 No 191 >4GMO_A Putative uncharacterized protein; ARM, HEAT, solenoid, nuclear transport; 2.1A {Chaetomium thermophilum var. thermophilum DSM 1495} Probab=95.93 E-value=5.4e-05 Score=85.22 Aligned_cols=94 Identities=14% Similarity=0.083 Sum_probs=69.0 Template_Neff=8.600 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLV-DLLRSPNQNVQQAAAGALRNLVFRS-TTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll-~lL~s~d~eVr~~AL~aLs~La~~~-~~~~ 322 (747) ..+..|+..|.+.++.++..++.+|.+++.. +.....+...++++.|+ .++.+.+..++..++.+|.+++... .... T Consensus 34 ~~i~~Li~~L~S~~~~~r~~A~~aL~~L~~d-~~~r~~l~~~g~i~~Li~~LL~d~~~~v~~~A~~aLrNLs~~~~~~~~ 112 (684) T 4GMO_A 34 DKILPVLKDLKSPDAKSRTTAAGAIANIVQD-AKCRKLLLREQVVHIVLTETLTDNNIDSRAAGWEILKVLAQEEEADFC 112 (684) T ss_dssp CCCHHHHHHHSSSCCSHHHHHHHHHHHHTTS-HHHHHHHHHTTHHHHCCCCCTTCSCHHHHHHHHHHHHHHHHHSCHHHH T ss_pred CChHHHHHHcCCCCHHHHHHHHHHHHHHhcC-HHHHHHHHHCChHHHHHHHHccCCCHHHHHHHHHHHHHHhccCChHHH Confidence 4566778888888888999999999998763 44555566678888888 8888878889999999999998652 2333 Q NP_000290.2 323 LETRRQNGIREAVSLLR 339 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ 339 (747) ..+...+++..|..++. T Consensus 113 ~~l~~~g~l~~L~~lL~ 129 (684) T 4GMO_A 113 VHLYRLDVLTAIEHAAK 129 (684) T ss_dssp HHHHHTTHHHHHHHHHH T ss_pred HHHHHCChHHHHHHHHH Confidence 34444566676666664 No 192 >4PLS_B Arm00010; PEPTIDE BINDING PROTEIN, designed armadillo; HET: CA; 2.35A {synthetic construct} Probab=95.89 E-value=4.9e-05 Score=69.42 Aligned_cols=134 Identities=25% Similarity=0.295 Sum_probs=87.2 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.+..++..++.++..++.......... T Consensus 86 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 165 (281) T 4PLS_B 86 ALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAV 165 (281) T ss_dssp CHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred cHHHHHHHcCCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCHHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666677788888888888876543333333344677777777777777888899999988876543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 166 ~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 221 (281) T 4PLS_B 166 IDAGALPALVQLLS-SPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLS 221 (281) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHCChHHHHHHHhc-CCcHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHcc Confidence 33456677777776 5567788888888888876422 2222222 56666666664 No 193 >5MFO_F YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: CA, EDO; 1.3A {synthetic construct} Probab=95.88 E-value=5e-05 Score=65.80 Aligned_cols=112 Identities=26% Similarity=0.298 Sum_probs=74.3 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.+..++..++.++..++.........+ T Consensus 89 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 168 (202) T 5MFO_F 89 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAV 168 (202) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHhcChHHHHHHH Confidence 45556666666677788888999988876543333333344677777777777777888889999988886543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++++.+..++. ..++.++..++.++..++ T Consensus 169 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~ 200 (202) T 5MFO_F 169 KEAGAEPALEQLQS-SPNEKIQKEAQEALEKIQ 200 (202) T ss_dssp HHTTHHHHHHTTTT-CSSHHHHHHHHHHHHHHH T ss_pred HHCCHHHHHHHHHc-CCCHHHHHHHHHHHHHHH Confidence 33456666777775 446677777777776654 No 194 >2RU4_A Armadillo Repeat Protein, N-terminal fragment; solenoid repeat, Armadillo repeat motif; NMR {synthetic construct} Probab=95.88 E-value=5.2e-05 Score=59.81 Aligned_cols=110 Identities=25% Similarity=0.264 Sum_probs=70.0 Template_Neff=12.800 Q NP_000290.2 248 PKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRR 327 (747) Q Consensus 248 ~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~ 327 (747) +.+...+...+..++..++.++..++.........+...+.++.+...+.+.++.++..++.++.+++.........+.. T Consensus 4 ~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~ 83 (115) T 2RU4_A 4 PQMTQQLNSDDMQEQLSATRKFSQILSDGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVID 83 (115) T ss_dssp CCCCCCCCCCCCCCCSCCCCCCCCCCCSCTTHHHHHCCSSSHHHHHHGGGSSCHHHHHHHHHHHHHHHTTCHHHHHHHHT T ss_pred HHHHHhhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCchHHHHHHH Confidence 34455555556677888888888887654333333444456777777777667778888888888887554333333333 Q NP_000290.2 328 QNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 328 ~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) .+.++.+...+. ..++.++..++.++.+++ T Consensus 84 ~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~ 113 (115) T 2RU4_A 84 AGALPALVQLLS-SPNEQILQEALWALSNIA 113 (115) T ss_dssp TTHHHHHHHGGG-SSCHHHHHHHHHHHHHHH T ss_pred CCcHHHHHHHhc-CCCHHHHHHHHHHHHHHh Confidence 456666666665 445667777777776654 No 195 >5AEI_B DESIGNED ARMADILLO REPEAT PROTEIN YIIIM5AII; DE NOVO PROTEIN, PROTEIN-PEPTIDE COMPLEX; HET: CA, ACT; 1.83A {SYNTHETIC CONSTRUCT} Probab=95.87 E-value=5.1e-05 Score=69.48 Aligned_cols=114 Identities=26% Similarity=0.296 Sum_probs=74.7 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++..+..........+...++++.+...+.+.+..++..++.++..++.........+ T Consensus 47 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 126 (286) T 5AEI_B 47 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 126 (286) T ss_dssp CHHHHHHGGGCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHHTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred HHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHcChHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHH Confidence 45556666666677888889999988876544333333344567777777777777888889999988876433332233 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++++.+...+. ..++.++..++.++..++.. T Consensus 127 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 160 (286) T 5AEI_B 127 IDAGALPALVQLLS-SPNEQILQEALWALSNIASG 160 (286) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTS T ss_pred HhCCHHHHHHHHcc-CCCHHHHHHHHHHHHHHHcC Confidence 33446666666665 44566777777777776653 No 196 >5MFD_C YIIIM''6AII, Capsid decoration protein,pD_(KR)5; Designed armadillo repeat protein, peptide; HET: CA; 2.3A {synthetic construct} Probab=95.87 E-value=5.1e-05 Score=70.81 Aligned_cols=157 Identities=20% Similarity=0.303 Sum_probs=116.5 Template_Neff=13.300 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) +.++++.+..++. +.++.++..++.+|.+++..... ....+...++++.+..++.+.++.++..++.+|.+++. T Consensus 128 ~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~ 201 (328) T 5MFD_C 128 DAGALPALVQLLS-SPNEQILQEALWTLGNIASGGNE-----QIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIAS 201 (328) T ss_dssp HTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHTTSCHH-----HHHHHHHTTHHHHHHHGGGCSCHHHHHHHHHHHHHHHT T ss_pred HCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHH-----HHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHHc Confidence 4456777888887 46777888899999998864332 22333456788888888888888899999999999987 Q NP_000290.2 625 H-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAE 702 (747) Q Consensus 625 ~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~ 702 (747) . ... ..+...++++.+..++.+ .++.++..++.+|.+++...+.....+...++++.+..++.+. ++.++. T Consensus 202 ~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~ 274 (328) T 5MFD_C 202 GGNEQIQAVIDAGALPALVQLLSS------PNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSP-NEQILQ 274 (328) T ss_dssp SCHHHHHHHHHTTCHHHHHHGGGC------SCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGCS-CHHHHH T ss_pred CCHHHHHHHHHCChHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHHCChHHHHHHHhcCC-CHHHHH Confidence 6 222 233445677888888766 3677889999999999865555545555566788888888766 788899 Q NP_000290.2 703 AARLLLSDMWSS 714 (747) Q Consensus 703 aAL~aLsnL~~~ 714 (747) .++.+|.+++.. T Consensus 275 ~a~~~l~~l~~~ 286 (328) T 5MFD_C 275 EALWTLGNIASG 286 (328) T ss_dssp HHHHHHHHHHTS T ss_pred HHHHHHHHHhCC Confidence 999999999865 No 197 >5MFO_E YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: EDO, CA; 1.3A {synthetic construct} Probab=95.87 E-value=5.2e-05 Score=65.68 Aligned_cols=112 Identities=26% Similarity=0.298 Sum_probs=74.3 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++...+.....+...++++.+...+.+.+..++..++.++..++.........+ T Consensus 89 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 168 (202) T 5MFO_E 89 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAV 168 (202) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHhcCHHHHHHHH Confidence 45556666666667788888899988876543333333344677777777777777888889999988886543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++++.+..++. ..++.++..++.++..++ T Consensus 169 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~ 200 (202) T 5MFO_E 169 KEAGAEPALEQLQS-SPNEKIQKEAQEALEKIQ 200 (202) T ss_dssp HHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHC T ss_pred HHCCHHHHHHHHHc-CCCHHHHHHHHHHHHHHH Confidence 33456666777775 446677777777776654 No 198 >5D5K_C Importin subunit alpha-1, Poly [ADP-ribose]; PARP-2 NLS, PARP-2, poly(ADP-ribose)polymerase-2, Importin; 1.9A {Mus musculus} Probab=95.85 E-value=5.5e-05 Score=74.91 Aligned_cols=158 Identities=19% Similarity=0.271 Sum_probs=114.4 Template_Neff=13.100 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDA-----TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASL 618 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~e-----Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~a 618 (747) .+.++++.++.++.. .+.. ++..++.+|.+++..... ........++++.+..++.+.++.++..++.+ T Consensus 138 ~~~~~~~~l~~~l~~-~~~~~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~ 211 (466) T 5D5K_C 138 IKHGAIDPLLALLAV-PDLSTLACGYLRNLTWTLSNLCRNKNP-----APPLDAVEQILPTLVRLLHHNDPEVLADSCWA 211 (466) T ss_dssp HHTTCHHHHHHTTCS-SCGGGSCHHHHHHHHHHHHHHSCCCSS-----CCCHHHHHHHHHHHHHHTTSSCHHHHHHHHHH T ss_pred HHCCcHHHHHHHhhC-CCcccccHHHHHHHHHHHHHHHcCCCC-----CCChHHHHHHHHHHHHHHcCCCHHHHHHHHHH Confidence 355667777777763 3333 677888888888765322 11121225678888888888888899999999 Q NP_000290.2 619 LSNMSRHPL-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA 696 (747) Q Consensus 619 LsnLa~~~e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~ 696 (747) |.+++.... . ..+...++++.+..++.+ .++.++..++.+|.+++...+.....+...++++.+..++.+. T Consensus 212 l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~- 284 (466) T 5D5K_C 212 ISYLTDGPNERIEMVVKKGVVPQLVKLLGA------TELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNP- 284 (466) T ss_dssp HHHHTSSCHHHHHHHHTTTCHHHHHHHHTC------SCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTGGGGHHHHTTCS- T ss_pred HHHHhcCCchHHHHHHHCChHHHHHHHhcC------CCchHHHHHHHHHHHHhcCCHHHHHHHHccChhHhHHHHhhCC- Confidence 999987632 2 233455677888888876 3678889999999999876455555566667888888888766 Q NP_000290.2 697 SPKAAEAARLLLSDMWSS 714 (747) Q Consensus 697 d~eVr~aAL~aLsnL~~~ 714 (747) ++.++..++.+|.+++.. T Consensus 285 ~~~v~~~a~~~l~~l~~~ 302 (466) T 5D5K_C 285 KTNIQKEATWTMSNITAG 302 (466) T ss_dssp SHHHHHHHHHHHHHHTTS T ss_pred CHHHHHHHHHHHHHHHcC Confidence 788899999999998875 No 199 >1XQS_B HSPBP1 protein, Heat shock 70; armadillo repeat, superhelical twist, CHAPERONE; HET: AMP; 2.9A {Homo sapiens} SCOP: a.118.1.21 Probab=95.84 E-value=5.9e-05 Score=71.37 Aligned_cols=116 Identities=18% Similarity=0.237 Sum_probs=80.5 Template_Neff=11.900 Q NP_000290.2 246 TIPKAVQYLSSQ-DEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ss-d~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+..++... +..++..++.++.+++.........+...+.++.+..++...+..++..++.++.+++......... T Consensus 109 ~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~ 188 (280) T 1XQS_B 109 ALRKLLRLLDRDACDTVRVKALFAISCLVREQEAGLLQFLRLDGFSVLMRAMQQQVQKLKVKSAFLLQNLLVGHPEHKGT 188 (280) T ss_dssp HHHHHHHHHHSCSCHHHHHHHHHHHHHTTSSCHHHHHHHHTTTHHHHHHHHHTSSCHHHHHHHHHHHHHHHHHCGGGHHH T ss_pred HHHHHHHHhccCCCHHHHHHHHHHHHHHHhcCHHHHHHHHHCCHHHHHHHHhhCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 455566666654 6778888999999988654433334444567777888777667778888999999888654423333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~ 362 (747) +...++++.+..++. ..++.++..++.++.+++.... T Consensus 189 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~ 225 (280) T 1XQS_B 189 LCSMGMVQQLVALVR-TEHSPFHEHVLGALCSLVTDFP 225 (280) T ss_dssp HHTTTHHHHHHHHHT-SSCCTTHHHHHHHTTTSSTTCH T ss_pred HHhCCHHHHHHHHHc-CCCcHHHHHHHHHHHHHHhcCH Confidence 444467777777776 5567788888999998887543 No 200 >4UAF_B Importin alpha 1 import receptor; importin karyopherin complex NLS, PROTEIN; HET: PO4; 1.698A {Mus musculus} Probab=95.82 E-value=5.9e-05 Score=74.70 Aligned_cols=158 Identities=19% Similarity=0.271 Sum_probs=114.6 Template_Neff=13.100 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDA-----TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASL 618 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~e-----Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~a 618 (747) .+.++++.++.++.. .+.. ++..++.+|.+++..... ........++++.+..++.+.++.++..++.+ T Consensus 138 ~~~~~~~~l~~~l~~-~~~~~~~~~~~~~~~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~ 211 (466) T 4UAF_B 138 IKHGAIDPLLALLAV-PDLSTLACGYLRNLTWTLSNLCRNKNP-----APPLDAVEQILPTLVRLLHHNDPEVLADSCWA 211 (466) T ss_pred HHCCcHHHHHHHhhC-CCcccccHHHHHHHHHHHHHHHcCCCC-----CCChhHHHHHHHHHHHHHcCCCHHHHHHHHHH Confidence 355667777777763 3333 677888888888865332 11121225678888888888888999999999 Q NP_000290.2 619 LSNMSRHPL-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA 696 (747) Q Consensus 619 LsnLa~~~e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~ 696 (747) |.+++.... . ..+...++++.+..++.+ .++.++..++.+|.+++...+.....+...++++.+..++.+. T Consensus 212 l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~- 284 (466) T 4UAF_B 212 ISYLTDGPNERIEMVVKKGVVPQLVKLLGA------TELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNP- 284 (466) T ss_pred HHHHhcCCcHHHHHHHHCChHHHHHHHhcC------CChhHHHHHHHHHHHHhcCCHHHHHHHhccCHHHHHHHHhcCC- Confidence 999987632 2 233455678888888876 3678889999999999876455555566667888888888766 Q NP_000290.2 697 SPKAAEAARLLLSDMWSS 714 (747) Q Consensus 697 d~eVr~aAL~aLsnL~~~ 714 (747) ++.++..++.+|.+++.. T Consensus 285 ~~~v~~~a~~~l~~l~~~ 302 (466) T 4UAF_B 285 KTNIQKEATWTMSNITAG 302 (466) T ss_pred CHHHHHHHHHHHHHHhcC Confidence 788899999999999875 No 201 >1XQR_A HspBP1 protein; armadillo repeat, superhelical twist, CHAPERONE; HET: MSE; 2.1A {Homo sapiens} SCOP: a.118.1.21 Probab=95.82 E-value=6.4e-05 Score=72.71 Aligned_cols=116 Identities=18% Similarity=0.237 Sum_probs=81.0 Template_Neff=11.300 Q NP_000290.2 246 TIPKAVQYLSSQ-DEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ss-d~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+..++... ++.++..++.++.+++.........+...++++.+...+...+..++..++.++.+++......... T Consensus 125 ~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~ 204 (296) T 1XQR_A 125 ALRKLLRLLDRDACDTVRVKALFAISCLVREQEAGLLQFLRLDGFSVLMRAMQQQVQKLKVKSAFLLQNLLVGHPEHKGT 204 (296) T ss_dssp HHHHHHHHHHHCSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHSSCHHHHHHHHHHHHHHHHHCGGGHHH T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhhCCCHHHHHHHHHHHHHHHcCCHHHHHH Confidence 455566666654 6778889999999998754433334444567777887777667788888999999888754433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~ 362 (747) +...++++.+..++. ..++.++..++.+|.+++.... T Consensus 205 ~~~~~~i~~L~~ll~-~~~~~~~~~a~~~L~~l~~~~~ 241 (296) T 1XQR_A 205 LCSMGMVQQLVALVR-TEHSPFHEHVLGALCSLVTDFP 241 (296) T ss_dssp HHHTTHHHHHHHHHT-SCCSTHHHHHHHHHHHHHTTCH T ss_pred HHhCCHHHHHHHHHc-CCChHHHHHHHHHHHHHHhcCH Confidence 444567777777776 4566788888899988887543 No 202 >6CRI_R Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=95.81 E-value=6.2e-05 Score=78.24 Aligned_cols=151 Identities=10% Similarity=0.021 Sum_probs=91.7 Template_Neff=12.500 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ---SGNSDVVRSGASLLSNMS 623 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~---s~d~eVr~~AL~aLsnLa 623 (747) ..++.|+.++. +.+..++..++.++..+....+. ....+++.+...+. ..+..++ .++++|+.+. T Consensus 414 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~----------~~~~~~~~l~~~l~~~~~~~~~~r-~a~~~l~~~~ 481 (585) T 6CRI_R 414 WHIDTIMRVLT-TAGSYVRDDAVPNLIQLITNSVE----------MHAYTVQRLYKAILGDYSQQPLVQ-VAAWCIGEYG 481 (585) T ss_pred HHHHHHHHHHH-HhccccCccHHHHHHHHHhcCch----------HHHHHHHHHHHHHHCCCCCHHHHH-HHHHHHHHHH Confidence 35566666666 35566777777777777653211 11234555666653 3344556 7888888877 Q NP_000290.2 624 RHPLLH--------RVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR 693 (747) Q Consensus 624 ~~~e~~--------~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~ 693 (747) ...... ......+++.|..++ .+ .+..++..++.+|..+....+. ....++..+..++. T Consensus 482 ~~~~~~~~~~~~~~~~~~~~~~~~L~~~l~~~~------~~~~vr~~a~~al~~l~~~~~~-----~~~~~~~~l~~~~~ 550 (585) T 6CRI_R 482 DLLVSGQCEEEEPIQVTEDEVLDILESVLISNM------STSVTRGYALTAIMKLSTRFTC-----TVNRIKKVVSIYGS 550 (585) T ss_pred HHhcCCCCCCCCCCCCCHHHHHHHHHHHhcccC------CCHHHHHHHHHHHHHHHhcCCc-----hHHHHHHHHHHHcc Confidence 642110 111234566666666 33 3567888999999998875332 22234555666666 Q NP_000290.2 694 SSASPKAAEAARLLLSDMWSSKELQGVL 721 (747) Q Consensus 694 s~~d~eVr~aAL~aLsnL~~~~~~~~~~ 721 (747) +. ++.++..++.++..+..+......+ T Consensus 551 ~~-~~~vr~~a~~~l~~l~~~~~~~~~l 577 (585) T 6CRI_R 551 SI-DVELQQRAVEYNALFKKYDHMRSAL 577 (585) T ss_pred CC-CHHHHHHHHHHHHHhhhHHHHHHHH Confidence 65 7889999999999988765544443 No 203 >6SA8_A ring-like DARPin-Armadillo fusion H83_D01, LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG; protein fusion, DARPin, Armadillo, shared; 2.4A {synthetic construct} Probab=95.78 E-value=6.8e-05 Score=80.44 Aligned_cols=136 Identities=26% Similarity=0.298 Sum_probs=92.6 Template_Neff=11.900 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.+|.+++...+.....+...++++.+..++.+.++.++..++.++..++......... T Consensus 262 ~~~~~l~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~L~~~l~~~~~~v~~~a~~~L~~l~~~~~~~~~~ 341 (671) T 6SA8_A 262 GALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQA 341 (671) T ss_dssp TCHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred CHHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCcHHHHHHHHhChHHHHHHHhcCCcHHHHHHHHHHHHHHhcCCcHHHHH Confidence 34556666666677788889999999887654333334444567788888888777888889999999987654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST-DELKEELIA-DALPVLADRVII 381 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~-~~~~~~Lve-giLe~Lv~LL~~ 381 (747) +...++++.+...+. ..++.++..++.++..++.. ......+.. ++++.|+.++.. T Consensus 342 ~~~~~~l~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~ 399 (671) T 6SA8_A 342 VIDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSS 399 (671) T ss_dssp HHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHGGGC T ss_pred HHhcChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCcHHHHHHHHcCcHHHHHHHhcC Confidence 334456777777776 55677888899999998873 332333333 677777776653 No 204 >5WBJ_A Regulatory-associated protein of TOR 1,Eukaryotic; Raptor, TOS, PROTEIN BINDING; 3.0A {Arabidopsis thaliana} Probab=95.77 E-value=8.1e-05 Score=89.51 Aligned_cols=168 Identities=12% Similarity=0.072 Sum_probs=120.9 Template_Neff=8.700 Q NP_000290.2 541 GWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG--NSDVVRSGASL 618 (747) Q Consensus 541 ~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~--d~eVr~~AL~a 618 (747) ..+...|+++.++.+|. +..++++..++.++.+++..++. .+..+.+.+++..|+.+|... .+.++..++.+ T Consensus 500 ~~~~~~gi~p~ll~lL~-s~~~~lr~~a~~i~a~i~~~d~~-----~q~~l~~~~~l~~ll~~L~~~~~~~~~r~~a~~~ 573 (1287) T 5WBJ_A 500 DLALSVGIFPYVLKLLQ-TTTNELRQILVFIWTKILALDKS-----CQIDLVKDGGHTYFIRFLDSSGAFPEQRAMAAFV 573 (1287) T ss_dssp HHHHHHTCHHHHHHGGG-CCCHHHHHHHHHHHHHHHHHCGG-----GHHHHHHTTCHHHHHHHHHCSSCCHHHHHHHHHH T ss_pred HHHHHCCcHHHHHHHHc-CCCHHHHHHHHHHHHHHHccCHH-----HHHHHHHcCCeeeEEEeecCCCCCHHHHHHHHHH Confidence 33457789999999998 47788899999999999876443 344556677888899988743 35567788999 Q NP_000290.2 619 LSNMSRH-PLL-HRVMGNQVFPEVTRLLTSHTG-NTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSS 695 (747) Q Consensus 619 LsnLa~~-~e~-~~ll~~giI~~Ll~LL~s~s~-~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~ 695 (747) |+.++.. ... ..+...+++..+...|..... ....++.++..++.+|..|+...+.........+++..|+.+|.+. T Consensus 574 Ls~l~~~~~~~~~~~~~~~~l~~l~~~L~~~~~~~~~~~~~lr~~a~~~L~~L~~~~~~~~~~~~~~~~~~~L~~lL~~~ 653 (1287) T 5WBJ_A 574 LAVIVDGHRRGQEACLEANLIGVCLGHLEASRPSDPQPEPLFLQWLCLCLGKLWEDFMEAQIMGREANAFEKLAPLLSEP 653 (1287) T ss_dssp HHHHHTTCHHHHHHHHHTTHHHHHHHHCC---------CHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHGGGGGCS T ss_pred HHHHHcCCHhHHHHHHHCcHHHHHHHHHHhcCCCCCCCCHHHHHHHHHHHHHHHhccHHHHHHHHHcCHHHHHHHHhcCC Confidence 9999876 222 233444677777777761000 0003678899999999999877555555556667788899999877 Q NP_000290.2 696 ASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 696 ~d~eVr~aAL~aLsnL~~~~ 715 (747) ++.++.+++.+|+.++... T Consensus 654 -~~~VRaaal~aL~~li~~~ 672 (1287) T 5WBJ_A 654 -QPEVRAAAVFALGTLLDIG 672 (1287) T ss_dssp -CHHHHHHHHHHHHHTCC-- T ss_pred -CHHHHHHHHHHHHHHHhcC Confidence 8899999999999998764 No 205 >5Z8H_A Adenomatous polyposis coli protein, Peptide; APC, inhibitor, PROTEIN BINDING-INHIBITOR complex; HET: PHQ, GOL; 1.79A {Homo sapiens} Probab=95.74 E-value=7.4e-05 Score=71.65 Aligned_cols=115 Identities=17% Similarity=0.172 Sum_probs=76.4 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQD----EKYQAIGAYYIQHTCF---QDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS 318 (747) Q Consensus 246 iL~~Ll~lL~ssd----~eVr~sAL~aLsnLs~---~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~ 318 (747) +++.+..++...+ ..++..++.++.++.. ........+...++++.+..++...++.++..++.++.+++... T Consensus 210 ~~~~l~~~l~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~L~~l~~~~ 289 (339) T 5Z8H_A 210 ALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARN 289 (339) T ss_pred hHHHHHHHhcCCCCCCCHHHHHHHHHHHHHHHHhhccCHHHHHHHHHCCHHHHHHHHHhCCCHHHHHHHHHHHHHHhCCC Confidence 4445555554332 5677778888887752 22223333334467777788787777788889999999988744 Q NP_000290.2 319 TTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD 361 (747) Q Consensus 319 ~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~ 361 (747) +.....+...++++.+..++. ..++.++..++.++.+++... T Consensus 290 ~~~~~~~~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~ 331 (339) T 5Z8H_A 290 PKDQEALWDMGAVSMLKNLIH-SKHKMIAMGSAAALRNLMANR 331 (339) T ss_pred HHHHHHHHHCCcHHHHHHHhh-CCCHHHHHHHHHHHHHHHcCC Confidence 443344444567788888886 556778888999998888643 No 206 >5WBK_A Regulatory-associated protein of TOR 1,Ribosomal; Raptor, TOS, PROTEIN BINDING; 3.11A {Arabidopsis thaliana} Probab=95.72 E-value=9.2e-05 Score=89.00 Aligned_cols=168 Identities=12% Similarity=0.072 Sum_probs=120.7 Template_Neff=8.700 Q NP_000290.2 541 GWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG--NSDVVRSGASL 618 (747) Q Consensus 541 ~~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~--d~eVr~~AL~a 618 (747) ..+...|+++.|+++|. +..++++..++.++.+++..++. .+..+.+.+++..|+.+|... .+.++..++.+ T Consensus 500 ~~~l~~Gi~p~ll~lL~-s~~~~lr~~a~~i~a~i~~~d~~-----~q~~l~~~~~l~~ll~~L~~~~~~~~~r~~a~~~ 573 (1287) T 5WBK_A 500 DLALSVGIFPYVLKLLQ-TTTNELRQILVFIWTKILALDKS-----CQIDLVKDGGHTYFIRFLDSSGAFPEQRAMAAFV 573 (1287) T ss_dssp HHHHHHTCHHHHHHGGG-CCCHHHHHHHHHHHHHHHHHCGG-----GHHHHHHTTTHHHHHHHHHSSCCCHHHHHHHHHH T ss_pred HHHHHCCcHHHHHHHHc-CCCHHHHHHHHHHHHHHHccCHH-----HHHHHHHcCCeeeEEEeecCCCCCHHHHHHHHHH Confidence 33457789999999998 46778899999999999876443 344456677888899988743 35567788899 Q NP_000290.2 619 LSNMSRH-PLL-HRVMGNQVFPEVTRLLTSHTG-NTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSS 695 (747) Q Consensus 619 LsnLa~~-~e~-~~ll~~giI~~Ll~LL~s~s~-~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~ 695 (747) |+.++.. ... ..+...+++..+...|..... ....++.++..++.+|+.|+...+.........+++..|+.+|.+. T Consensus 574 Ls~l~~~~~~~~~~~~~~~~l~~l~~~L~~~~~~~~~~~~~lr~~a~~~L~~L~~~~~~~~~~~~~~~~~~~L~~lL~~~ 653 (1287) T 5WBK_A 574 LAVIVDGHRRGQEACLEANLIGVCLGHLEASRPSDPQPEPLFLQWLCLCLGKLWEDFMEAQIMGREANAFEKLAPLLSEP 653 (1287) T ss_dssp HHHHHTTCHHHHHHHHHTTHHHHHHHHCC---------CHHHHHHHHHHHHHHHTTCHHHHHHHHTTTHHHHHGGGGGCS T ss_pred HHHHHcCCHhHHHHHHHCcHHHHHHHHHHhcCCCCCCCCHHHHHHHHHHHHHHHcccHHHHHHHHHCCHHHHHHHHhcCC Confidence 9999876 222 233444677777777761000 0003678899999999999876555555556667788899999877 Q NP_000290.2 696 ASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 696 ~d~eVr~aAL~aLsnL~~~~ 715 (747) ++.+|.+++.+|+.++... T Consensus 654 -~~~VRaaal~AL~~li~~~ 672 (1287) T 5WBK_A 654 -QPEVRAAAVFALGTLLDIG 672 (1287) T ss_dssp -CHHHHHHHHHHHHHHCC-- T ss_pred -CHHHHHHHHHHHHHHHhcC Confidence 8899999999999998764 No 207 >6SA6_A DARPin-Armadillo fusion A5; protein fusion, DARPin, Armadillo, shared; HET: EDO; 1.6A {synthetic construct} Probab=95.69 E-value=8.4e-05 Score=73.16 Aligned_cols=135 Identities=25% Similarity=0.260 Sum_probs=92.1 Template_Neff=12.400 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+..++.+.++.++..++.+|.+++.........+...++++.+..++...++.++..++.+|..++......... T Consensus 241 ~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~ 320 (397) T 6SA6_A 241 GALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQA 320 (397) T ss_dssp THHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHH T ss_pred CcHHHHHHHhcCCCHHHHHHHHHHHHHHhcCcHHHHHHHHhCChHHHHHHHhcCCcHHHHHHHHHHHHHHhcCcHHHHHH Confidence 34566666777777888889999999987654333333444467777888887777788888899998887654433333 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST-DELKEELIA-DALPVLADRVI 380 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~-~~~~~~Lve-giLe~Lv~LL~ 380 (747) +...++++.+..++. ..++.++..++.++..++.. ......+.. ++++.|..++. T Consensus 321 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 377 (397) T 6SA6_A 321 VIDAGALPALVQLLS-SPNEQILQEALWTLGNIASGGNEQKQAVKEAGALEKLEQLQS 377 (397) T ss_dssp HHHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHhcChHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCCHHHHHHHHHcCchHHHHHHHh Confidence 444567777888776 55678888899999998874 333333333 67777777664 No 208 >2W3C_A GENERAL VESICULAR TRANSPORT FACTOR P115; MEMBRANE VESICLE TETHERING, ARMADILLO FOLD; HET: PEG; 2.22A {HOMO SAPIENS} Probab=95.59 E-value=0.00012 Score=79.14 Aligned_cols=136 Identities=15% Similarity=0.146 Sum_probs=91.0 Template_Neff=10.400 Q NP_000290.2 246 TIPKAVQYLSSQ--DEKYQAIGAYYIQHTCFQDES-----------------AKQQVY-QLGGICKLVDLLRSPNQNVQQ 305 (747) Q Consensus 246 iL~~Ll~lL~ss--d~eVr~sAL~aLsnLs~~~~~-----------------~~~~li-~~~IL~~Ll~lL~s~d~eVr~ 305 (747) .++.++..+.+. +..+...++.+|..++..... ....+. ..+.++.++.++.+.+..++. T Consensus 9 ~l~~Li~~L~~~~~~~~~~~~al~~L~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~L~~ll~~~~~~v~~ 88 (577) T 2W3C_A 9 AMEHLIHVLQTDRSDSEIIGYALDTLYNIISNEEEEEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEEFDFHVRW 88 (577) T ss_dssp TTHHHHHHHHHCTTCHHHHHHHHHHHHHHHHC------------------CHHHHHHHHSTHHHHHHHHHTTCCCHHHHH T ss_pred hHHHHHHHHhhCCCcHHHHHHHHHHHHHHhCCCchhhhhhccccccHHHHHHHHHHHHhcCchHHHHHHHccCCCHHHHH Confidence 345566666543 456778888888888765431 122233 456777788888777788899 Q NP_000290.2 306 AAAGALRNLVFRST-TNKLETR-RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTD-ELKEELIA-DALPVLADRVII 381 (747) Q Consensus 306 ~AL~aLs~La~~~~-~~~~~ll-~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~-~~~~~Lve-giLe~Lv~LL~~ 381 (747) .++.+|..++...+ .....+. ..+.++.++.++. ..+..++..++.+|.+++... .....+.. ++++.|+.++.. T Consensus 89 ~a~~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~-~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~g~~~~L~~ll~~ 167 (577) T 2W3C_A 89 PGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLA-DSREVIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIISE 167 (577) T ss_dssp HHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHHGGGG-CSSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHH T ss_pred HHHHHHHHHHHhchHHHHHHHHhCCChHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHcCCHHHHHHHHHHH Confidence 99999999886543 2222333 2467888888886 556788999999999998743 33333333 889999988875 Q NP_000290.2 382 P 382 (747) Q Consensus 382 ~ 382 (747) . T Consensus 168 ~ 168 (577) T 2W3C_A 168 E 168 (577) T ss_dssp T T ss_pred h Confidence 3 No 209 >6CRI_I Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=95.58 E-value=0.0001 Score=74.75 Aligned_cols=106 Identities=11% Similarity=0.025 Sum_probs=69.8 Template_Neff=13.200 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.+..++..++.++..+.... ....+++.+...+.+.++.++..++.++..+......... T Consensus 72 ~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~-------~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~~~~~ 144 (570) T 6CRI_I 72 IMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDK-------ITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVE 144 (570) T ss_dssp GTTHHHHHHHTSSSCHHHHHHHHHHHHHCCCTT-------TTTTSHHHHHHHHTCSSHHHHHHHHHHHHHHHHHCHHHHH T ss_pred HHHHHHHHHHcCCCCHHHHHHHHHHHccCChhH-------HHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHHhChhhhh Confidence 344555666666677778888888887775321 1123556666667777788888899988888754332211 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...+++.+...+. +.++.++..++.++..+... T Consensus 145 ---~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~ 177 (570) T 6CRI_I 145 ---DQGFLDTLKDLIS-DSNPMVVANAVAALSEIAES 177 (570) T ss_dssp ---HHTHHHHHHHHHT-SSSHHHHHHHHHHHHHHHHH T ss_pred ---ccchHHHHHHHhc-CCCHHHHHHHHHHHHHHHhh Confidence 1345666677776 56778888899888888764 No 210 >1QBK_B STRUCTURE OF THE KARYOPHERIN BETA2-RAN; HEAT REPEATS, NUCLEAR TRANSPORT PROTEIN; HET: GNP; 3.0A {Homo sapiens} SCOP: a.118.1.1 Probab=95.57 E-value=0.00011 Score=79.31 Aligned_cols=157 Identities=12% Similarity=0.081 Sum_probs=97.3 Template_Neff=13.200 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.+...+. +.++.++..++.+|..++...+. ....+ -..+++.+...+.+.+..++..++.++..++... T Consensus 667 ~~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~ 739 (890) T 1QBK_B 667 NILTLMYQCMQ-DKMPEVRQSSFALLGDLTKACFQ-----HVKPC-IADFMPILGTNLNPEFISVCNNATWAIGEISIQM 739 (890) T ss_pred hHHHHHHHHHh-CCCHHHHHHHHHHHHHHHHHhHH-----hHHHH-HHHHHHHHHhhcCcccHHHHHHHHHHHHHHHHHc Confidence 35566666666 36778888899999988764321 11111 1346667777777777889999999999988652 Q NP_000290.2 627 -LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 -e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .........+++.+...+.+. ..+..++..++.+|+.++...+....... ..++..++..+....++.++..++ T Consensus 740 ~~~~~~~~~~i~~~l~~~l~~~----~~~~~~r~~a~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~~~~~~~~~~~ 814 (890) T 1QBK_B 740 GIEMQPYIPMVLHQLVEIINRP----NTPKTLLENTAITIGRLGYVCPQEVAPML-QQFIRPWCTSLRNIRDNEEKDSAF 814 (890) T ss_pred CccccchHHHHHHHHHHHHcCC----CCCccHHHHHHHHHHHHHhhCHHhHHHHH-HHhHHHHHHHHhcCCChHHHHHHH Confidence 211112234566677766541 01567888999999998875332211111 234555666555432567788888 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .+|..+.... T Consensus 815 ~~l~~l~~~~ 824 (890) T 1QBK_B 815 RGICTMISVN 824 (890) T ss_pred HHHHHHHhhC Confidence 8888776543 No 211 >4P6Z_G BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=95.56 E-value=0.00012 Score=77.66 Aligned_cols=151 Identities=10% Similarity=0.027 Sum_probs=89.9 Template_Neff=12.000 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ---SGNSDVVRSGASLLSNMS 623 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~---s~d~eVr~~AL~aLsnLa 623 (747) ..++.|+.++. +.++.++..++.+|..+....+. ....+++.+...+. ..+..++ .++++|+.+. T Consensus 431 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~----------~~~~~~~~l~~~l~~~~~~~~~~r-~a~~~l~~~~ 498 (627) T 4P6Z_G 431 WHIDTIMRVLT-TAGSYVRDDAVPNLIQLITNSVE----------MHAYTVQRLYKAILGDYSQQPLVQ-VAAWCIGEYG 498 (627) T ss_dssp HHHHHHHHHHH-HTGGGSCGGGHHHHHHHHHSCTT----------TTHHHHHHHHHHHHHCCCSHHHHH-HHHHHHHHTH T ss_pred HHHHHHHHHHH-hhccccCcchHHHHHHHHhcCch----------HHHHHHHHHHHHHHcCCCCHHHHH-HHHHHHHHHH Confidence 35566666665 35566677777777776643211 01234455555553 2334555 7778887776 Q NP_000290.2 624 RHPLL-H-------RVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR 693 (747) Q Consensus 624 ~~~e~-~-------~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~ 693 (747) ..... . ......+++.|..++ .+ .++.++..++.+|..+....+. ....++..|..++. T Consensus 499 ~~~~~~~~~~~~~~~~~~~~~~~~L~~~l~~~~------~~~~vr~~a~~~L~~l~~~~~~-----~~~~~~~~l~~~~~ 567 (627) T 4P6Z_G 499 DLLVSGQCEEEEPIQVTEDEVLDILESVLISNM------STSVTRGYALTAIMKLSTRFTC-----TVNRIKKVVSIYGS 567 (627) T ss_dssp HHHHSCCCTTSCCCCCCSHHHHHHHHHHHHCTT------CCHHHHHHHHHHHHHHHHHCCS-----CHHHHHHHHHHGGG T ss_pred HHhccCCCCCCCCCCCCHHHHHHHHHHHHcccC------CCHHHHHHHHHHHHHHHhhccc-----hHHHHHHHHHHHcc Confidence 54111 0 011124566666666 33 3567889999999998865332 22234566666666 Q NP_000290.2 694 SSASPKAAEAARLLLSDMWSSKELQGVL 721 (747) Q Consensus 694 s~~d~eVr~aAL~aLsnL~~~~~~~~~~ 721 (747) +. +..++..++.++..+..+......| T Consensus 568 ~~-~~~vr~~a~~~l~~l~~~~~~~~~l 594 (627) T 4P6Z_G 568 SI-DVELQQRAVEYNALFKKYDHMRSAL 594 (627) T ss_dssp CS-CHHHHHHHHHHHHHHHHCTTHHHHH T ss_pred CC-CHHHHHHHHHHHHHhhhHHHHHHHH Confidence 65 7889999999999988764444443 No 212 >5MFI_B YIII(Dq.V2)4CqI, (KR)4; Designed armadillo repeat protein, peptide; 1.45A {synthetic construct} Probab=95.46 E-value=0.00014 Score=65.05 Aligned_cols=112 Identities=20% Similarity=0.227 Sum_probs=75.6 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++.+++...+.....+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 131 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 210 (243) T 5MFI_B 131 ALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKL 210 (243) T ss_dssp CHHHHHHTTTSSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHGGGCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666667788888889888876544333333444577778888877778888899999998886444333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++++.+..++. ..++.++..++.++..++ T Consensus 211 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~ 242 (243) T 5MFI_B 211 EEAGAEPALEKLQS-SPNEEVQKNAQAALEALN 242 (243) T ss_dssp HHTTHHHHHHHGGG-CSCHHHHHHHHHHHHHHC T ss_pred HHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHhc Confidence 33456667777775 456677777777777654 No 213 >5MFJ_B YIII(Dq.V2)4CqI, (KR)5; Designed armadillo repeat protein, peptide; 1.53A {synthetic construct} Probab=95.46 E-value=0.00014 Score=65.05 Aligned_cols=112 Identities=20% Similarity=0.227 Sum_probs=75.6 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++.+++...+.....+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 131 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 210 (243) T 5MFJ_B 131 ALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKLIEAGALSPLVKLLDDASEEVIQEAVWAIANIASGNNEQIQKL 210 (243) T ss_dssp CHHHHHHTTTSSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTCHHHHHHGGGCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred cHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCcHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666666667788888889888876544333333444577778888877778888899999998886444333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++++.+..++. ..++.++..++.++..++ T Consensus 211 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~ 242 (243) T 5MFJ_B 211 EEAGAEPALEKLQS-SPNEEVQKNAQAALEALN 242 (243) T ss_dssp HHTTHHHHHHHTSS-CSCHHHHHHHHHHHHHHC T ss_pred HHCCcHHHHHHHhc-CCCHHHHHHHHHHHHHhc Confidence 33456667777775 456677777777777654 No 214 >5EWP_B Uncharacterized protein; translocation and attachment of rhoptries; 1.8A {Plasmodium falciparum Santa Lucia} Probab=95.43 E-value=0.00015 Score=67.32 Aligned_cols=134 Identities=16% Similarity=0.127 Sum_probs=89.1 Template_Neff=11.800 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+..++...+..++..++.++.+++.........+...+.++.++.++...+..++..++.++.+++.........+ T Consensus 87 ~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~~~~~~~ 166 (252) T 5EWP_B 87 GIAVFINLLKSHELDRVHAAVVALSFLSVDNVKNCICMFESGALPYLISGMKSNIDGMKAACAQTCRNIFVLDKKYKKEF 166 (252) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTTCHHHHHHHHHTTCHHHHHHHTTCSCHHHHHHHHHHHHHHHTTCHHHHHHH T ss_pred cHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHhhCCCHHHHHHHHHHHHHHHhcCHHHHHHH Confidence 45556666666667788889999999887544444445555677888888877677888999999999876533333344 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNA-------EIQKQLTGLLWNLSSTDEL-----KEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~-------eVr~~AL~aLsnLas~~~~-----~~~Lve-giLe~Lv~LL~ 380 (747) ...+.++.+..++. .... .++..++.++..++..... ...+.. ++++.|..++. T Consensus 167 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~l~~~~~~~~L~~~l~ 233 (252) T 5EWP_B 167 LKLGGITQLVNLLE-LPSNYDDSQPLYTQLEAIYHLEDFILNDGDEIPEFLEAVKNSNSIKNLKTLQQ 233 (252) T ss_dssp HHTTHHHHHHHTTS-CCTTCCSCSCCHHHHHHHHHHHHHHEETTEECHHHHHHHHTTTHHHHHHHHTT T ss_pred HHCChHHHHHHHhc-CCCCCCCCchHHHHHHHHHHHHHHHhcCCCccHHHHHHHHhCChHHHHHHHhh Confidence 44567777777775 3333 2777788888888764331 223333 66777777663 No 215 >4V3Q_A YIII_M4_AII; DE NOVO PROTEIN, PROTEIN ENGINEERING; HET: GOL, CA; 1.8A {SYNTHETIC CONSTRUCT} Probab=95.36 E-value=0.00017 Score=64.82 Aligned_cols=134 Identities=25% Similarity=0.303 Sum_probs=88.0 Template_Neff=12.900 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++..++...+.....+...++++.+...+.+.+..++..++.++..++.........+ T Consensus 51 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 130 (247) T 4V3Q_A 51 ALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAV 130 (247) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred cHHHHHHHhcCCCHHHHHHHHHHHHHHHcCcHHHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45556666766677888889999998876544333334445677788888877778888889999988875443333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE-LKEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~-~~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++.... ....+.. ++++.+..++. T Consensus 131 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 186 (247) T 4V3Q_A 131 IDAGALPALVQLLS-SPNEQILQEALWTLGNIASGGDEQIQAVIDAGALPALVQLLS 186 (247) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHCCHHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCCcHHHHHHHhc Confidence 34466777777776 4566778888888888876432 2222222 55666665554 No 216 >3GQ2_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.18A {Bos taurus} Probab=95.28 E-value=0.00022 Score=78.31 Aligned_cols=135 Identities=13% Similarity=0.116 Sum_probs=92.0 Template_Neff=10.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQ-QVY-QLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~-~li-~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .++.++.++...+..++..++.+|..++...+.... .+. ..+.++.++.++.+.+..++..++.+|..++........ T Consensus 123 ~i~~Ll~ll~~~~~~~~~~al~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~~~~~~i~~~a~~~L~~l~~~~~~~~~ 202 (651) T 3GQ2_A 123 NVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQK 202 (651) T ss_dssp HHHTHHHHTTCCCHHHHHHHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHGGGGGCSSHHHHHHHHHHHHHHHTTCHHHHH T ss_pred hHHHHHHHccCCCHHHHHHHHHHHHHHHHhccHHHHHHHHhCccHHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCHHHHH Confidence 455566666666778889999999998865432221 222 345778888888877778889999999999874444434 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGN----AEIQKQLTGLLWNLSSTDELKEE-LIA-DALPVLADRVII 381 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d----~eVr~~AL~aLsnLas~~~~~~~-Lve-giLe~Lv~LL~~ 381 (747) .+...+.++.++.++. ... ..++..++.+|.+++........ +.+ ++++.|+.+|.. T Consensus 203 ~l~~~g~~~~L~~ll~-~~~~~~~~~v~~~al~~L~~L~~~~~~~~~~~~e~~~i~~L~~lL~~ 265 (651) T 3GQ2_A 203 IVAFENAFERLLDIIT-EEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYIQRMKPWFEV 265 (651) T ss_dssp HHHHTTHHHHHHHHHH-HTTGGGSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCGGGTGGGGCC T ss_pred HHHhCChHHHHHHHHH-HhCCCCccHHHHHHHHHHHHHHhCCHHHHHHHHhcChHHHHHHHHhc Confidence 4445577888888876 322 25777888899998875433333 334 788888888864 No 217 >3GRL_A General vesicular transport factor p115; vesicle transport, membrane trafficking, membrane; 2.0A {Bos taurus} Probab=95.28 E-value=0.00022 Score=78.31 Aligned_cols=135 Identities=13% Similarity=0.116 Sum_probs=92.0 Template_Neff=10.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQ-QVY-QLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~-~li-~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .++.++.++...+..++..++.+|..++...+.... .+. ..+.++.++.++.+.+..++..++.+|..++........ T Consensus 123 ~i~~Ll~ll~~~~~~~~~~al~~L~~l~~~~~~~~~~~i~~~~~~i~~Lv~lL~~~~~~i~~~a~~~L~~l~~~~~~~~~ 202 (651) T 3GRL_A 123 NVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQK 202 (651) T ss_dssp HHHHHHHHTTCCCHHHHHHHHHHHHHHHHHSHHHHHHHHHHSTTHHHHHHGGGGCSSHHHHHHHHHHHHHHHTTCHHHHH T ss_pred hHHHHHHHccCCCHHHHHHHHHHHHHHHHhccHHHHHHHHhCccHHHHHHHHhcCCCHHHHHHHHHHHHHHhCCCHHHHH Confidence 455566666666778889999999998865432221 222 345778888888877778889999999999874444434 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGN----AEIQKQLTGLLWNLSSTDELKEE-LIA-DALPVLADRVII 381 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d----~eVr~~AL~aLsnLas~~~~~~~-Lve-giLe~Lv~LL~~ 381 (747) .+...+.++.++.++. ... ..++..++.+|.+++........ +.+ ++++.|+.+|.. T Consensus 203 ~l~~~g~~~~L~~ll~-~~~~~~~~~v~~~al~~L~~L~~~~~~~~~~~~e~~~i~~L~~lL~~ 265 (651) T 3GRL_A 203 IVAFENAFERLLDIIT-EEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYIQRMKPWFEV 265 (651) T ss_dssp HHHHTTHHHHHHHHHH-HHTGGGSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTCGGGGGGGGCC T ss_pred HHHhCChHHHHHHHHH-HhCCCCccHHHHHHHHHHHHHHhCCHHHHHHHHhcChHHHHHHHHhc Confidence 4445577888888876 322 25777888899998875433333 334 788888888864 No 218 >5AFF_A SYMPORTIN 1, RIBOSOMAL PROTEIN L5; CHAPERONE, RIBOSOME BIOGENESIS, ALPHA SOLENOID.; 3.398A {CHAETOMIUM THERMOPHILUM} Probab=95.22 E-value=0.00026 Score=78.85 Aligned_cols=94 Identities=14% Similarity=0.083 Sum_probs=66.2 Template_Neff=8.800 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLV-DLLRSPNQNVQQAAAGALRNLVFRS-TTNK 322 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll-~lL~s~d~eVr~~AL~aLs~La~~~-~~~~ 322 (747) ..++.|+..+.+.++..+..++.+|.+++.. +.....+...++++.|+ .++.+.+..++..++.+|.+++... .... T Consensus 12 ~~i~~Li~~L~s~~~~~r~~A~~aL~~L~~d-~~~r~~ll~~g~v~~Li~~lL~d~~~~v~~~a~~aLrnLs~~~~~~~~ 90 (654) T 5AFF_A 12 DKILPVLKDLKSPDAKSRTTAAGAIANIVQD-AKCRKLLLREQVVHIVLTETLTDNNIDSRAAGWEILKVLAQEEEADFC 90 (654) T ss_dssp HHHHHHHHHHHSSCTTHHHHHHHHHHHHHCC-HHHHHHHHHTTHHHHHHHTGGGCSSHHHHHHHHHHHHHHHHHSCHHHH T ss_pred CchHHHHHHcCCCCHHHHHHHHHHHHHHHcC-HHHHHHHHHCChHHHHHHHHccCCCHHHHHHHHHHHHHHhccCchhHH Confidence 3456677777777888899999999998754 44444555567888887 7787777889999999999997643 2222 Q NP_000290.2 323 LETRRQNGIREAVSLLR 339 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ 339 (747) ..++..+++..|..++. T Consensus 91 ~~l~~~~il~~L~~lL~ 107 (654) T 5AFF_A 91 VHLYRLDVLTAIEHAAK 107 (654) T ss_dssp HHHHHTTHHHHHHHHHH T ss_pred HHHHHCChHHHHHHHHH Confidence 33444566666666654 No 219 >6QH5_B AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=95.19 E-value=0.00023 Score=72.97 Aligned_cols=107 Identities=12% Similarity=0.043 Sum_probs=72.0 Template_Neff=12.900 Q NP_000290.2 243 SGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNK 322 (747) Q Consensus 243 ~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~ 322 (747) ...+++.+...+.+.++.++..++.++..+.... ....+++.+...+.+.++.++..++.++..+....+... T Consensus 84 ~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~-------~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~ 156 (592) T 6QH5_B 84 AIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDK-------ITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMV 156 (592) T ss_pred HHHHHHHHHHHccCCCHHHHHHHHHHHHHHcchh-------hHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCchhh Confidence 4445666666777777888888888888775421 112355666666777778889999999888875433211 Q NP_000290.2 323 LETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 323 ~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ....+++.+...+. +.++.++..++.++..+... T Consensus 157 ---~~~~~~~~l~~~l~-d~~~~vr~~a~~~l~~~~~~ 190 (592) T 6QH5_B 157 ---EDQGFLDSLRDLIA-DSNPMVVANAVAALSEISES 190 (592) T ss_pred ---cCccHHHHHHHHhC-CCCHHHHHHHHHHHHHHHhc Confidence 11245666666675 55678888899988888764 No 220 >3C2G_A Sys-1 protein, Pop-1 8-residue peptide; beta-catenin, phylogeny, SYS-1, POP-1, Caenorhabditis; HET: MSE; 2.5A {Caenorhabditis elegans} Probab=95.17 E-value=0.00033 Score=77.69 Aligned_cols=189 Identities=17% Similarity=0.156 Sum_probs=108.5 Template_Neff=5.600 Q NP_000290.2 260 KYQAIGAYYIQHTCFQDESAKQQVYQL-GG----------ICKLVDLLRSP----------------N----QNVQQAAA 308 (747) Q Consensus 260 eVr~sAL~aLsnLs~~~~~~~~~li~~-~I----------L~~Ll~lL~s~----------------d----~eVr~~AL 308 (747) .+...++.++..++..+......+... +. +..|+.++... + +.+...+. T Consensus 185 ~~~~~i~d~Lr~L~~~n~~~K~~~l~~~g~~~~~~~~~~~I~~Ll~IL~~~~~~~~~~~~e~~~~~~~~~~~e~ll~~t~ 264 (619) T 3C2G_A 185 MINPAIFIIFRFIISKDTRLKDYFIWNNNPHDQPPPPTGLIIKLNAVMIGSYRLIAGQNPETLPQNPELAHLIQVIIRTF 264 (619) T ss_dssp GCCTHHHHHHHHHHTTCHHHHHHHHHTTCCTTSCCCTTSHHHHHHHHHHHHHHHHTTCCGGGGGGCHHHHHHHHHHHHHH T ss_pred chHHHHHHHHHHHhcCCHHHHHHHHhcCCCCCCCCCCchHHHHHHHHHHHhHhhhcCCCcccCCCCccHHHHHHHHHHHH Confidence 344556667777766544443333332 23 56676666531 1 44555666 Q NP_000290.2 309 GALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCD 388 (747) Q Consensus 309 ~aLs~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL~~~~~~~~~ 388 (747) .+|..+. ........+...+.++.|...+. ..++.+...++++|.++.........-+++.+..++.+|.. T Consensus 265 ~lLk~Ls-~~sn~a~~~V~~gGvq~L~~~L~-~~S~rlv~~~L~~LrnlSDa~~~~~~~l~~ll~~lv~ll~~------- 335 (619) T 3C2G_A 265 DLLGLLL-HDSDAIDGFVRSDGVGAITTVVQ-YPNNDLIRAGCKLLLQVSDAKALAKTPLENILPFLLRLIEI------- 335 (619) T ss_dssp HHHHHHC-CSHHHHHHHHHTTHHHHHHHHTT-SSCHHHHHHHHHHHHHHTTCGGGGTSCCTTHHHHHHHHHHH------- T ss_pred HHHHHHh-CCcchHHHHHHCCHHHHHHHHcc-CCCHHHHHHHHHHHHHHHchHHHcCCchHHHHHHHHHHHhc------- Confidence 7777666 33333345666788888888886 67788999999999999865432212223566667776621 Q NP_000290.2 389 GNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAA---- 464 (747) Q Consensus 389 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~---- 464 (747) .-|+.+..-+||+|..-. ....--+.+---.|-|+.|+.-+..+... T Consensus 336 --------~~D~~iv~~~tG~LsNlt---------------------~nn~~NK~~~i~~ggi~~Li~~i~~~~~~~~~~ 386 (619) T 3C2G_A 336 --------HPDDEVIYSGTGFLSNVV---------------------AHKQHVKDIAIRSNAIFLLHTIISKYPRLDELT 386 (619) T ss_dssp --------CCCHHHHHHHHHHHHHHS---------------------TTCHHHHHHHHHTTHHHHHHHHHHTSCCGGGCC T ss_pred --------CCCHHHHHHHHHHHHHHH---------------------cCChhHHHHHHhCCHHHHHHHHHHhCCccccCC Confidence 237888888898875311 11111111111234445555444333210 Q NP_000290.2 465 ----SRCDDKSVENCMCVLHNLSYRL 486 (747) Q Consensus 465 ----~~~~~~~~~~~~~~~~~~~~~~ 486 (747) -+-...-.|||.|.|+||..+- T Consensus 387 ~~~~~~~~eeI~e~~l~aLr~Lt~~h 412 (619) T 3C2G_A 387 DAPKRNRVCEIICNCLRTLNNFLMMW 412 (619) T ss_dssp SHHHHHHHHHHHHHHHHHHHHHHGGG T ss_pred CCchhhhhHHHHHHHHHHHHHHhccC Confidence 0011345899999999998874 No 221 >4FDD_A Transportin-1, RNA-binding protein FUS; HEAT repeats, Karyopherin, nuclear import; 2.3A {Homo sapiens} Probab=95.09 E-value=0.00028 Score=75.31 Aligned_cols=157 Identities=12% Similarity=0.083 Sum_probs=93.3 Template_Neff=13.300 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) ..++.+...+. +.++.++..++.++..++...+. ..... -..+++.+...+.+.+..++..++.++..++.. T Consensus 629 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~ 701 (852) T 4FDD_A 629 NILTLMYQCMQ-DKMPEVRQSSFALLGDLTKACFQ-----HVKPC-IADFMPILGTNLNPEFISVCNNATWAIGEISIQM 701 (852) T ss_dssp CHHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHCGG-----GTGGG-HHHHHHHHHHTCCTTSHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHh-CCCHHHHHHHHHHHHHHHHHHHH-----hHHHH-HHHHHHHHHhhCCcccHHHHHHHHHHHHHHHHHc Confidence 35566666666 35677888899999988764321 11111 134666677777777788888999999888765 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ..........+++.+...+... ..+..++..++.+|..+....+....... ..++..++..+....+..++..++ T Consensus 702 ~~~~~~~~~~i~~~l~~~l~~~----~~~~~~~~~~~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~~~~~~~~~a~ 776 (852) T 4FDD_A 702 GIEMQPYIPMVLHQLVEIINRP----NTPKTLLENTAITIGRLGYVCPQEVAPML-QQFIRPWCTSLRNIRDNEEKDSAF 776 (852) T ss_dssp GGGGGGGTHHHHHHHHHHHTCS----SCCHHHHHHHHHHHHHHHHHCHHHHGGGH-HHHHHHHHHHHHTSCSSHHHHHHH T ss_pred CccchhhHHHHHHHHHHHHcCC----CCChhHHHHHHHHHHHHHHHCHHHhHHHH-HHhHHHHHHHhhcCCCHHHHHHHH Confidence 2111111123556666666541 01467788888999888765332111111 124445555554322567788888 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .+|..++... T Consensus 777 ~~l~~l~~~~ 786 (852) T 4FDD_A 777 RGICTMISVN 786 (852) T ss_dssp HHHHHHHHHC T ss_pred HHHHHHHhhC Confidence 8887776543 No 222 >4P6Z_B BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=95.03 E-value=0.00031 Score=72.53 Aligned_cols=106 Identities=11% Similarity=0.035 Sum_probs=69.9 Template_Neff=12.700 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.++.++..++.++..+.... ....+++.+...+.+.++.++..++.++..+....+... T Consensus 101 ~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~-------~~~~~~~~l~~~l~~~~~~vr~~a~~~L~~l~~~~~~~~- 172 (600) T 4P6Z_B 101 IMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDK-------ITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLV- 172 (600) T ss_pred HHHHHHHHHHccCCCHHHHHHHHHHHhcCCchH-------HHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHhhChHHh- Confidence 344555566666667788888888887775321 112455666666777778888889998888875433211 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ....+++.+...+. +.++.++..++.++..+... T Consensus 173 --~~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~ 206 (600) T 4P6Z_B 173 --EDQGFLDTLKDLIS-DSNPMVVANAVAALSEIAES 206 (600) T ss_pred --hccChHHHHHHHhc-CCCHHHHHHHHHHHHHHHhh Confidence 11345666777775 55678888888888888764 No 223 >2JKT_A AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ALTERNATIVE SPLICING, PHOSPHOPROTEIN, PHOSPHORYLATION, PROTEIN; HET: SEP, SO4; 3.4A {MUS MUSCULUS} Probab=95.01 E-value=0.00032 Score=73.46 Aligned_cols=144 Identities=13% Similarity=0.048 Sum_probs=89.0 Template_Neff=12.300 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSD--VVRSGASLLSNMSR 624 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~e--Vr~~AL~aLsnLa~ 624 (747) ..++.|+.++. +.+..++..++.++..+...... ....+++.|...+.+.+.. ++..++++|+.+.. T Consensus 441 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~----------~~~~~~~~l~~~l~~~~~~~~v~~~a~~~l~~~~~ 509 (623) T 2JKT_A 441 WYVDTILNLIR-IAGDYVSEEVWYRVIQIVINRDD----------VQGYAAKTVFEALQAPACHENLVKVGGYILGEFGN 509 (623) T ss_dssp HHHHHHHHHTT-TTGGGCCHHHHHHHHHHHHHCST----------THHHHHHHHHHHTTSSSCCHHHHHHHHHHHHHSST T ss_pred HHHHHHHHHHH-HHcccCCHHHHHHHHHHHhcChh----------HHHHHHHHHHHHHhCccCCHHHHHHHHHHHHHHHH Confidence 35666777776 35566777788888777653211 1234566666666655544 78888888888775 Q NP_000290.2 625 HPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLC---RSSASPKA 700 (747) Q Consensus 625 ~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL---~s~~d~eV 700 (747) .... .......+++.|...+.+ .+..++..++.+|..++...+. . ...+..++..+ .+. ++.+ T Consensus 510 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~a~~al~~l~~~~~~-----~-~~~l~~ll~~l~~~~~~-~~~v 576 (623) T 2JKT_A 510 LIAGDPRSSPLIQFNLLHSKFHL------CSVPTRALLLSTYIKFVNLFPE-----V-KATIQDVLRSDSQLKNA-DVEL 576 (623) T ss_dssp TSSSSGGGCHHHHHHHHHHHHTT------SCHHHHHHHHHHHHHHHHHCTT-----T-HHHHHTTSSSHHHHTCS-SHHH T ss_pred HhcCCCCCChHHHHHHHHHhcCC------CCHHHHHHHHHHHHHHHHhCHH-----H-HHHHHHHHHhccccCCC-CHHH Confidence 4111 111111355566666655 3577889999999998864332 1 13455555555 444 7788 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..+... T Consensus 577 r~~a~~~l~~~~~~ 590 (623) T 2JKT_A 577 QQRAVEYLRLSTVA 590 (623) T ss_dssp HHHHHHHHHHHHSS T ss_pred HHHHHHHHHHhccC Confidence 99999998877654 No 224 >5IZ8_A Adenomatous polyposis coli protein, ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2; APC, ASEF, Colon CANCER, Drug; HET: PGE; 3.06A {Homo sapiens} Probab=94.95 E-value=0.00036 Score=67.82 Aligned_cols=162 Identities=22% Similarity=0.254 Sum_probs=121.7 Template_Neff=12.000 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLK-EKGLPQIARLLQSGN----SDVVRSGAS 617 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie-~giI~~Ll~LL~s~d----~eVr~~AL~ 617 (747) +.+.++++.|+.++....++.++..++++|.+++...+. ....+.+ .++++.|+.++...+ ..++..++. T Consensus 166 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~ 240 (354) T 5IZ8_A 166 LREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTE-----NKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGG 240 (354) T ss_dssp HHHTTHHHHHHHHHHHCCSHHHHHHHHHHHHHHHTSCHH-----HHHHHHTSTTHHHHHHHHTTCCCTTSCCHHHHHHHH T ss_pred HHHCCHHHHHHHHHHhcCCHHHHHHHHHHHHHHHcCChH-----hHHHHHhhccHHHHHHHHHhhcCCCCcHHHHHHHHH Confidence 356778888888887225677888999999999875232 2334455 688899998887533 678888999 Q NP_000290.2 618 LLSNMSR----HPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLC 692 (747) Q Consensus 618 aLsnLa~----~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL 692 (747) +|.+++. .... ..+...++++.++.++.. .++.++..++.+|.+++...+.....+.+.++++.|+.++ T Consensus 241 ~L~~l~~~~~~~~~~~~~l~~~~~~~~l~~~l~~------~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l 314 (354) T 5IZ8_A 241 ILRNVSSLIATNEDHRQILRENNCLQTLLQHLKS------HSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLI 314 (354) T ss_dssp HHHHHHHHHHTCHHHHHHHHTTTHHHHHHHTTTC------SCHHHHHHHHHHHHHHSSSCHHHHHHHHTTTHHHHHHHHS T ss_pred HHHHHHHHhcCCHHHHHHHHHCCHHHHHHHHhhc------CCHHHHHHHHHHHHHHHccCHHHHHHHHhCCHHHHHHHHH Confidence 9999873 2222 233455678888888876 3677899999999999985466666677778889999988 Q NP_000290.2 693 RSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 693 ~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) .+. ++.++..++.+|.+++...+ T Consensus 315 ~~~-~~~v~~~a~~~L~~l~~~~~ 337 (354) T 5IZ8_A 315 HSK-HKMIAMGSAAALRNLMANRP 337 (354) T ss_dssp SCS-SHHHHHHHHHHHHHHHTTCC T ss_pred hcc-CHHHHHHHHHHHHHHHccCc Confidence 866 78899999999999997764 No 225 >5IZA_A Adenomatous polyposis coli protein, ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2; APC, ASEF, Colon CANCER, Drug; 1.5A {Homo sapiens} Probab=94.95 E-value=0.00036 Score=67.81 Aligned_cols=162 Identities=22% Similarity=0.254 Sum_probs=121.8 Template_Neff=12.000 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLK-EKGLPQIARLLQSGN----SDVVRSGAS 617 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie-~giI~~Ll~LL~s~d----~eVr~~AL~ 617 (747) +.+.++++.|+.++....++.++..++++|.+++...+. ....+.+ .++++.|+.++...+ ..++..++. T Consensus 166 ~~~~~~~~~l~~~l~~~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~ 240 (354) T 5IZA_A 166 LREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTE-----NKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGG 240 (354) T ss_dssp HHHTTHHHHHHHHHHHCCCHHHHHHHHHHHHHHHTTCHH-----HHHHHHTSTTHHHHHHHHTCSSCSSCCHHHHHHHHH T ss_pred HHHCCHHHHHHHHHHhcCCHHHHHHHHHHHHHHHcCChH-----hHHHHHhhccHHHHHHHHHhhcCCCCcHHHHHHHHH Confidence 356778888888887225677888999999999875232 2334455 688899998887533 678888999 Q NP_000290.2 618 LLSNMSR----HPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLC 692 (747) Q Consensus 618 aLsnLa~----~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL 692 (747) +|.+++. .... ..+...++++.++.++.. .++.++..++.+|.+++...+.....+.+.++++.|+.++ T Consensus 241 ~L~~l~~~~~~~~~~~~~l~~~~~~~~l~~~l~~------~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l 314 (354) T 5IZA_A 241 ILRNVSSLIATNEDHRQILRENNCLQTLLQHLKS------HSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLI 314 (354) T ss_dssp HHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHTSSCHHHHHHHHHTTHHHHHHTTT T ss_pred HHHHHHHHhcCCHHHHHHHHHCCHHHHHHHHhhc------CCHHHHHHHHHHHHHHHccCHHHHHHHHhCCHHHHHHHHH Confidence 9999873 2222 233455678888888876 3677899999999999985466666677778889999988 Q NP_000290.2 693 RSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 693 ~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) .+. ++.++..++.+|.+++...+ T Consensus 315 ~~~-~~~v~~~a~~~L~~l~~~~~ 337 (354) T 5IZA_A 315 HSK-HKMIAMGSAAALRNLMANRP 337 (354) T ss_dssp TCS-SHHHHHHHHHHHHHHHHTCC T ss_pred hcc-CHHHHHHHHHHHHHHHccCc Confidence 866 78899999999999997764 No 226 >5YVI_A Transportin-1, RNA-binding protein FUS; Importin family, PROTEIN TRANSPORT, PROTEIN; 2.9A {Homo sapiens} Probab=94.92 E-value=0.00036 Score=74.50 Aligned_cols=156 Identities=12% Similarity=0.081 Sum_probs=94.0 Template_Neff=13.300 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.+...+. +.++.++..++.++..++..... .... .-..+++.+...+.+.+..++..++.++..++... T Consensus 645 ~~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~l~~l~~~l~~~~~~v~~~a~~~l~~l~~~~ 717 (868) T 5YVI_A 645 NILTLMYQCMQ-DKMPEVRQSSFALLGDLTKACFQ-----HVKP-CIADFMPILGTNLNPEFISVCNNATWAIGEISIQM 717 (868) T ss_dssp CHHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHCHH-----HHGG-GHHHHHHHHHHTCCTTSHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHh-CCCHHHHHHHHHHHHHHHHHhHH-----hHHH-HHHHHHHHHHhcCCcccHHHHHHHHHHHHHHHHHc Confidence 34555666665 35677888899999888764321 0111 11346666777777777888999999999888652 Q NP_000290.2 627 -LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 -e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .........+++.+...+.+. ..+..++..++.+|..++...+....... ..+++.++..+.+..++.++..++ T Consensus 718 ~~~~~~~~~~i~~~l~~~l~~~----~~~~~~~~~~~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~~~~~~r~~~~ 792 (868) T 5YVI_A 718 GIEMQPYIPMVLHQLVEIINRP----NTPKTLLENTAITIGRLGYVCPQEVAPML-QQFIRPWCTSLRNIRDNEEKDSAF 792 (868) T ss_dssp GGGGGGGGGGTHHHHHHHHTCT----TCCHHHHHHHHHHHHHHHHHCHHHHGGGH-HHHHHHHHHHHTTSCSSHHHHHHH T ss_pred cccchhcHHHHHHHHHHHhcCC----CCChhHHHHHHHHHHHHHHHCHHHHHHHH-HHHHHHHHHHhhcCCChHHHHHHH Confidence 111111123566666666541 01467888899999988865332111111 234555555555322567888888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .++..+... T Consensus 793 ~~l~~l~~~ 801 (868) T 5YVI_A 793 RGICTMISV 801 (868) T ss_dssp HHHHHC-CC T ss_pred HHHHHHHhh Confidence 888888754 No 227 >6QH7_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: SEP; 3.4A {Rattus norvegicus} Probab=94.91 E-value=0.00038 Score=73.02 Aligned_cols=108 Identities=17% Similarity=0.103 Sum_probs=69.7 Template_Neff=12.200 Q NP_000290.2 242 CSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLL--RSPNQNVQQAAAGALRNLVFRST 319 (747) Q Consensus 242 ~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL--~s~d~eVr~~AL~aLs~La~~~~ 319 (747) ....+++.+...+.+.++.++..++.++..+.... ....+++.+...+ .+.++.++..++.++..+..... T Consensus 108 ~~~~~~~~l~~~l~~~~~~vr~~al~~l~~~~~~~-------~~~~l~~~l~~~l~~~~~~~~vr~~a~~~L~~~~~~~~ 180 (621) T 6QH7_A 108 LIRLINNAIKNDLASRNPTFMGLALHCIANVGSRE-------MAEAFAGEIPKILVAGDTMDSVKQSAALCLLRLYRTSP 180 (621) T ss_dssp HHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHCCHH-------HHHHHTTHHHHHHTTSCCCHHHHHHHHHHHHHHHHHCG T ss_pred HHHHHHHHHHHHHhcCCHHHHHHHHHHHHhhCCHH-------HHHHHHhhHHHHHHcCCCCHHHHHHHHHHHHHHHHHCh Confidence 33445556666666677788888888888775421 1123455566666 66677888888888888765332 Q NP_000290.2 320 TNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 320 ~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ... .....++.+...+. +.++.++..++.++..+... T Consensus 181 ~~~---~~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~ 217 (621) T 6QH7_A 181 DLV---PMGDWTSRVVHLLN-DQHLGVVTAATSLITTLAQK 217 (621) T ss_dssp GGC---CCCTTHHHHHHGGG-CSSHHHHHHHHHHHHHHHTT T ss_pred hhc---CccchHHHHHHHhc-CCCHHHHHHHHHHHHHHHHh Confidence 211 11245566667775 55677888888888887753 No 228 >1B3U_A PROTEIN PHOSPHATASE PP2A, 65 KD; SCAFFOLD PROTEIN, PP2A, PHOSPHORYLATION, HEAT; 2.3A {Homo sapiens} SCOP: a.118.1.2 Probab=94.85 E-value=0.0004 Score=70.07 Aligned_cols=146 Identities=11% Similarity=0.055 Sum_probs=95.0 Template_Neff=13.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.+..++. +.+..++..++.+|..+...... . . ....+++.+...+.+.+..++..++.++..+.... T Consensus 441 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~------~-~-~~~~~~~~l~~~l~~~~~~~r~~~~~~l~~l~~~~ 511 (588) T 1B3U_A 441 KLNSLCMAWLV-DHVYAIREAATSNLKKLVEKFGK------E-W-AHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVC 511 (588) T ss_dssp HHHHHHHHGGG-CSSHHHHHHHHHHHHHHHHHHCH------H-H-CCCCCHHHHHHTTTCSCHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHhc-CChHHHHHHHHHHHHHHHHHhCh------H-H-HHHhHHHHHHHhhcCCCHHHHHHHHHHHHHHHHHh Confidence 34566667776 46677888888888888764221 1 1 12356677777777777888888888888887642 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .. ......+++.+...+.+ .++.++..++.++..+...... ......+++.+...+.+. ++.++..+.. T Consensus 512 ~~-~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~---~~~~~~~~~~l~~~l~~~-~~~vr~~a~~ 580 (588) T 1B3U_A 512 GQ-DITTKHMLPTVLRMAGD------PVANVRFNVAKSLQKIGPILDN---STLQSEVKPILEKLTQDQ-DVDVKYFAQE 580 (588) T ss_dssp HH-HHCCCCCHHHHHHGGGC------SCHHHHHHHHHHHHHHGGGSCH---HHCCCCCHHHHHHHTTCS-SHHHHHHHHH T ss_pred CH-HHHHhchHHHHHHHhCC------CcHHHHHHHHHHHHHHHHHhcC---CcchHHHHHHHHHHhcCC-ChhHHHHHHH Confidence 11 11123455666666665 3678899999999988754211 112224566677777765 7788888888 Q NP_000290.2 707 LLSDMW 712 (747) Q Consensus 707 aLsnL~ 712 (747) ++..+. T Consensus 581 ~l~~l~ 586 (588) T 1B3U_A 581 ALTVLS 586 (588) T ss_dssp HHHHTT T ss_pred HHHHhh Confidence 887765 No 229 >4HM9_A Beta-catenin-like protein 1; all alpha-helical, armadillo repeats, PROTEIN; 3.1001A {Homo sapiens} Probab=94.77 E-value=0.00057 Score=75.04 Aligned_cols=161 Identities=14% Similarity=0.093 Sum_probs=111.6 Template_Neff=8.100 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSK--KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-----SG----NSDV 611 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~--d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-----s~----d~eV 611 (747) +.+.++++.|+.+|.. . ....+..|+.+|.+|+...+. ....+.+.++++.|+.+|. ++ .... T Consensus 241 i~~~g~l~~Ll~lL~~-~~~~~~~k~~AaeiL~~L~~~~~~-----~r~~l~~~g~I~~LL~lL~~y~~~d~~~~~e~e~ 314 (568) T 4HM9_A 241 GAQQGLLQWLLKRLKA-KMPFDANKLYCSEVLAILLQDNDE-----NRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEM 314 (568) T ss_dssp HCCCCCHHHHHHHHHS-SCCCCHHHHHHHHHHHHHHTTCHH-----HHHHHHHTTHHHHHHHHHGGGTTSCCSSSHHHHH T ss_pred HHHCCHHHHHHHHHHc-CCCCHHHHHHHHHHHHHHHcCCHH-----HHHHHHhCchHHHHHHHHHhhhccCCCCHHHHHH Confidence 3567889999999983 3 466778899999999875332 2444456889999999995 11 1234 Q NP_000290.2 612 VRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS--QPQLAKQYFSSSMLNNI 688 (747) Q Consensus 612 r~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~--s~e~~~~Lve~giL~~L 688 (747) ...++.+|.+++..+.. ..++..++++.++.+|.. ....+..|+.+|..++.. .......+++.+++..| T Consensus 315 ~en~~~aL~~L~~~~~~r~~f~~~~gv~lLv~lL~~-------~~~~~~~Al~vL~~a~~~~~~~~~~~~~ve~ggl~~L 387 (568) T 4HM9_A 315 MENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLRE-------KKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTI 387 (568) T ss_dssp HHHHHHHHHHHTTSTHHHHHHHHTTHHHHHHHHHHH-------TSTTHHHHHHHHHHHHCSGGGHHHHHHHHHTTCHHHH T ss_pred HHHHHHHHHHHhCCHHHHHHHHHCChHHHHHHHHhC-------ChhHHHHHHHHHHHHhcCCCChhHHHHHHHHchHHHH Confidence 55668888888876544 355666788888888875 234567778888665442 34456677777888888 Q NP_000290.2 689 INLCRSS---------ASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 689 l~LL~s~---------~d~eVr~aAL~aLsnL~~~~~ 716 (747) +.++... ......+.++.+|..|+.... T Consensus 388 ~~ll~~~~~~~~~~~~~~~e~~E~~~~iL~sL~~~~~ 424 (568) T 4HM9_A 388 FPLFMKSPRKIKKVGTTEKEHEEHVCSILASLLRNLR 424 (568) T ss_dssp HHHHHSCCCCCSSSSCCHHHHHHHHHHHHHHHHHHCC T ss_pred HHHHhcCcchhcCCCCCHHHHHHHHHHHHHHHHhcCC Confidence 8876532 134567888888888886543 No 230 >6QH5_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=94.76 E-value=0.00048 Score=72.19 Aligned_cols=144 Identities=13% Similarity=0.054 Sum_probs=85.0 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSD--VVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~e--Vr~~AL~aLsnLa~~ 625 (747) .++.|+..+. +.++.++..++.++..+...... ....+++.+...+.+.+.. ++..++++++.+... T Consensus 442 ~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~----------~~~~~~~~l~~~l~~~~~~~~vr~~a~~~l~~~~~~ 510 (621) T 6QH5_A 442 YVDTILNLIR-IAGDYVSEEVWYRVIQIVINRDD----------VQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNL 510 (621) T ss_pred HHHHHHHHhc-CCCHHHcHHHHHHHHHHHhcCHH----------HHHHHHHHHHHHhhCCCCCHHHHHHHHHHHHHHHhh Confidence 4556666665 34556666777777766543111 1233455666666655544 777788888777654 Q NP_000290.2 626 P-LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLC---RSSASPKAA 701 (747) Q Consensus 626 ~-e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL---~s~~d~eVr 701 (747) . .........+++.|...+.+ .+..++..++.+|..+....+. . ...+..++..+ .+. ++.++ T Consensus 511 ~~~~~~~~~~~~~~~L~~~l~~------~~~~vr~~a~~al~~l~~~~~~-----~-~~~l~~ll~~l~~~~~~-~~~vr 577 (621) T 6QH5_A 511 IAGDPRSSPLIQFNLLHSKFHL------CSVPTRALLLSTYIKFVNLFPE-----V-KATIQDVLRSDSQLKNA-DVELQ 577 (621) T ss_pred CCCCCCCCHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhCHH-----H-HhHHHHHHHHHHhcCCC-CHHHH Confidence 1 11110111245556666655 3567888899999988764322 1 12344555544 444 77889 Q NP_000290.2 702 EAARLLLSDMWSSK 715 (747) Q Consensus 702 ~aAL~aLsnL~~~~ 715 (747) ..++.++..+.... T Consensus 578 ~~a~~~l~~~~~~~ 591 (621) T 6QH5_A 578 QRAVEYLRLSTVAS 591 (621) T ss_pred HHHHHHHHHhCCCc Confidence 99999988876543 No 231 >5MFO_F YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: CA, EDO; 1.3A {synthetic construct} Probab=94.68 E-value=0.00052 Score=58.87 Aligned_cols=134 Identities=25% Similarity=0.276 Sum_probs=89.8 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++.........+...++++.+...+.+.+..++..++.++..++...+.....+ T Consensus 47 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~ 126 (202) T 5MFO_F 47 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 126 (202) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45566666777777888899999999886544333334444577777777777777888889999998876543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..+..++..++.++..++..... ...+.. ++++.|..++. T Consensus 127 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 182 (202) T 5MFO_F 127 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQKQAVKEAGAEPALEQLQS 182 (202) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHTTTT T ss_pred HHCCHHHHHHHHhc-CCCHHHHHHHHHHHHHHhcChHHHHHHHHHCCHHHHHHHHHc Confidence 34456777777776 55677888888999888875322 222222 56666666664 No 232 >5MFO_E YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: EDO, CA; 1.3A {synthetic construct} Probab=94.66 E-value=0.00054 Score=58.80 Aligned_cols=134 Identities=25% Similarity=0.276 Sum_probs=89.7 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++.++.+++.........+...++++.+...+.+.+..++..++.++..++.........+ T Consensus 47 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 126 (202) T 5MFO_E 47 ALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAV 126 (202) T ss_dssp HHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHhhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 45566666777778888899999999886544333334444577777777777777888889999988876543333333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..+..++..++.++..++..... ...+.. ++++.|..++. T Consensus 127 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 182 (202) T 5MFO_E 127 IDAGALPALVQLLS-SPNEQILQEALWALSNIASGGNEQKQAVKEAGAEPALEQLQS 182 (202) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHHHHHHHHHTTHHHHHHHHTT T ss_pred HHCCHHHHHHHHhc-CCCHHHHHHHHHHHHHHhcCHHHHHHHHHHCCHHHHHHHHHc Confidence 33456777777776 55677888889999888875322 222222 56666666654 No 233 >4MFU_A Beta-catenin-like protein 1; ARM repeats, GENE REGULATION; 2.744A {Homo sapiens} Probab=94.63 E-value=0.00067 Score=72.78 Aligned_cols=161 Identities=14% Similarity=0.093 Sum_probs=111.4 Template_Neff=8.700 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSK--KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-----SG----NSDV 611 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~--d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-----s~----d~eV 611 (747) +.+.++++.|+.++.. . ....+..++.+|.+++...+. ....+.+.++++.|+.++. ++ .... T Consensus 163 i~~~~~l~~Ll~~L~~-~~~~~~~k~~a~~~L~~L~~~~~~-----~~~~l~~~g~i~~Ll~lL~~~~~~d~~~~~~~e~ 236 (490) T 4MFU_A 163 GAQQGLLQWLLKRLKA-KMPFDANKLYCSEVLAILLQDNDE-----NRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEM 236 (490) T ss_dssp HCCCCCHHHHHHHHHC-CSCCCHHHHHHHHHHHHHHTTCHH-----HHHHHHHTTHHHHHHHHHHTTSSSCCSSHHHHHH T ss_pred HHHCCHHHHHHHHHHc-CCCCHHHHHHHHHHHHHHHcCCHH-----HHHHHHhCchHHHHHHHHHhhhhcCCCCHHHHHH Confidence 3567889999999983 3 467788899999999875332 2444456789999999985 11 1234 Q NP_000290.2 612 VRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS--QPQLAKQYFSSSMLNNI 688 (747) Q Consensus 612 r~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~--s~e~~~~Lve~giL~~L 688 (747) ...++.+|++++..+.. ..++..++++.++.++.. ....+..|+.+|...+.. ++.....+++.+++..| T Consensus 237 ~en~~~aL~~L~~~~~~~~~f~~~~gi~llv~lL~~-------~~~~~~~AL~~L~~a~~~~~~~~~~~~~v~~ggl~~L 309 (490) T 4MFU_A 237 MENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLRE-------KKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTI 309 (490) T ss_dssp HHHHHHHHHHHHHSTHHHHHHHHTTHHHHHHHHHHT-------TSSTHHHHHHHHHHHHSSGGGHHHHHHHHHTTHHHHH T ss_pred HHHHHHHHHHHhCCHHHHHHHHHCCcHHHHHHHHhC-------ChhHHHHHHHHHHHHhcCCCCHHHHHHHHHHchHHHH Confidence 45568888888876444 355666788888888865 234566677777665442 34456677777888888 Q NP_000290.2 689 INLCRSS---------ASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 689 l~LL~s~---------~d~eVr~aAL~aLsnL~~~~~ 716 (747) +.++... .+..+.+.++.+|..|+.... T Consensus 310 ~~~l~~~~~~~~~~~~~~~~~~E~~~~il~sL~~~~~ 346 (490) T 4MFU_A 310 FPLFMKSPRKIKKVGTTEKEHEEHVCSILASLLRNLR 346 (490) T ss_dssp HHHHHCCCCSCCSSCCCSHHHHHHHHHHHHHHHHHCC T ss_pred HHHHhcCcccccCCCCCHHHHHHHHHHHHHHHHhcCC Confidence 8877542 134677888899888887543 No 234 >2NYL_A Protein phosphatase 2, regulatory subunit; HEAT repeat, HYDROLASE-HYDROLASE INHIBITOR COMPLEX; HET: DAL, MSE, ACB, 1ZN, DAM, FGA; 3.8A {Homo sapiens} SCOP: a.118.1.2 Probab=94.58 E-value=0.00059 Score=68.47 Aligned_cols=145 Identities=11% Similarity=0.056 Sum_probs=94.9 Template_Neff=13.500 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+..++. +.++.++..++.+|..+...... . . ....+++.+...+.+.+..++..++.++..+..... T Consensus 436 ~~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~------~-~-~~~~~~~~l~~~l~~~~~~~r~~~~~~l~~l~~~~~ 506 (582) T 2NYL_A 436 LNSLCMAWLV-DHVYAIREAATSNLKKLVEKFGK------E-W-AHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCG 506 (582) T ss_dssp CHHHHHHGGG-CSSHHHHHHHHHHHHHHHHHHHH------H-H-HHHHTHHHHHHTTTCSSHHHHHHHHHHHHHHGGGSC T ss_pred HHHHHHHHhc-CCHHHHHHHHHHHHHHHHHHHCh------h-h-HHhcHHHHHHHhcCCCcHHHHHHHHHHHHHHHHHhC Confidence 4555666776 46777888899998888764221 1 1 124566777777777778888888998888876421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) .. .....+++.+...+.+ .++.++..++.++..+...... ......+++.+...+.+. ++.++..++.+ T Consensus 507 ~~-~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~---~~~~~~~~~~l~~~l~~~-~~~vr~~a~~~ 575 (582) T 2NYL_A 507 QD-ITTKHMLPTVLRMAGD------PVANVRFNVAKSLQKIGPILDN---STLQSEVKPILEKLTQDQ-DVDVKYFAQEA 575 (582) T ss_dssp HH-HHHHHTHHHHHHTSSC------SSHHHHHHHHHHHTTSSTTSCH---HHCCCCCHHHTTTTTTCS-SHHHHHHHHTT T ss_pred HH-HHHhcHHHHHHHHhcC------ChHHHHHHHHHHHHHHHHHcCC---CCcHHHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 11 1123355666666665 3678889999999988764211 112224566677777665 77888888888 Q NP_000290.2 708 LSDMW 712 (747) Q Consensus 708 LsnL~ 712 (747) +..++ T Consensus 576 l~~l~ 580 (582) T 2NYL_A 576 LTVLS 580 (582) T ss_dssp TTTTT T ss_pred HHHhc Confidence 88765 No 235 >4U2X_F eVP24, KPNA5C; eVP24, importin alpha6, immune antagonist; 3.153A {Zaire ebolavirus} Probab=94.35 E-value=0.00082 Score=57.14 Aligned_cols=73 Identities=21% Similarity=0.253 Sum_probs=49.2 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQ-DESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS 318 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~-~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~ 318 (747) +++.+...+.+.++.++..++.++.+++.. .+.....+...++++.+...+...++.++..++.++.+++... T Consensus 51 ~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~ 124 (175) T 4U2X_F 51 IFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLG 124 (175) T ss_dssp CHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHTCHHHHHHGGGCSCHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHhCCHHHHHHHHHHHHHHhcCCCHHHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHHhcc Confidence 455555666666677888888999888753 2223333334466777777777666777888888888887643 No 236 >3SL9_B Catenin beta-1, B-cell CLL/lymphoma 9; Armadillo repeat, components of the; HET: GOL, EDO, PEG, IMD; 2.2A {Homo sapiens} Probab=94.35 E-value=0.00082 Score=56.48 Aligned_cols=110 Identities=24% Similarity=0.309 Sum_probs=73.4 Template_Neff=12.600 Q NP_000290.2 246 TIPKAVQYLSS-QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~s-sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.. .+..++..++.++.+++.. +.....+...++++.+..++...++.++..++.++.+++......... T Consensus 56 ~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~-~~~~~~~~~~~~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 134 (167) T 3SL9_B 56 MVSAIVRTMQNTNDVETARCTAGTLHNLSHH-REGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMA 134 (167) T ss_pred hHHHHHHHHhcCCCHHHHHHHHHHHHHHcCC-HhHHHHHHHCCcHHHHHHHhCCCCHHHHHHHHHHHHHHHcCCHhHHHH Confidence 55566666665 5677888889999888743 333334444567788888887777788888999999888654332222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNL 357 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnL 357 (747) ....++++.+..++. ..++.++..++.++..+ T Consensus 135 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l 166 (167) T 3SL9_B 135 VRLAGGLQKMVALLN-KTNVKFLAITTDCLQIL 166 (167) T ss_pred HHHcCHHHHHHHHhc-CCCHHHHHHHHHHHHHh Confidence 222456777777776 45566777777776654 No 237 >4I5L_D PP2A A alpha subunit (9-589); EF Hand, Phosphatase, CDC6 (Substrate); HET: FGA, ACB, DAL, MLI, PEG, 1ZN, MAA; 2.43A {Microcystis aeruginosa} Probab=94.34 E-value=0.0008 Score=67.65 Aligned_cols=110 Identities=11% Similarity=0.101 Sum_probs=57.6 Template_Neff=13.400 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL-E 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~-~ 324 (747) +++.+...+.+.++.++..++.++..+...... ......+++.+...+.+.++.++..++.++..+......... . T Consensus 239 ~~~~l~~~l~~~~~~vr~~~~~~l~~l~~~~~~---~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~ 315 (584) T 4I5L_D 239 VMPTLRQAAEDKSWRVRYMVADKFTELQKAVGP---EITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCREN 315 (584) T ss_dssp THHHHHHHHTCSSHHHHHHHHHTHHHHHHHHHH---HHCCCCCHHHHHHHHTCSSHHHHHHHHTTHHHHHHTSCTTTHHH T ss_pred HHHHHHHHhhCCCHHHHHHHHHHHHHHHHHHCC---CCChhhHHHHHHHHhcCCcHHHHHHHHHHHHHHHHhcCccchhh Confidence 334444455555666777777777666543221 111123455566666666667777777777776643221110 0 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) .....+++.+...+. +.++.++..++.++..+.. T Consensus 316 ~~~~~~~~~l~~~l~-~~~~~vr~~~~~~l~~l~~ 349 (584) T 4I5L_D 316 VIMSQILPCIKELVS-DANQHVKSALASVIMGLSP 349 (584) T ss_dssp HCCCCCHHHHHHHHT-CSCHHHHHHHHTTGGGGHH T ss_pred HHHHhHHHHHHHHcc-CCCHHHHHHHHHHHHHHHH Confidence 111234455555554 3445566666666665544 No 238 >4U2X_E eVP24, KPNA5C; eVP24, importin alpha6, immune antagonist; 3.153A {Zaire ebolavirus} Probab=94.27 E-value=0.00091 Score=56.83 Aligned_cols=73 Identities=21% Similarity=0.253 Sum_probs=49.3 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQ-DESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS 318 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~-~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~ 318 (747) +++.+...+.+.++.++..++.++.+++.. .......+...+.++.+...+.+.++.++..++.++.+++... T Consensus 51 ~i~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~ 124 (175) T 4U2X_E 51 IFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLG 124 (175) T ss_dssp CHHHHHHHHHHSCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHTCHHHHHHGGGCSCHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHhcCHHHHHHHHHHHHHHcCCCCHHHHHHHHHCCcHHHHHHHhcCCCHHHHHHHHHHHHHHHhhc Confidence 445555666666677888889999988753 2222333334456777777777667778888888888887654 No 239 >4UQI_B AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ENDOCYTOSIS, PROTEIN TRANSPORT, LIPID BINDING; HET: IHP; 2.79A {RATTUS NORVEGICUS} Probab=94.24 E-value=0.00095 Score=70.34 Aligned_cols=106 Identities=12% Similarity=0.039 Sum_probs=70.7 Template_Neff=12.200 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.++.++..++.++..+.... ....+++.+...+.+.++.++..++.++..+........ T Consensus 85 ~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~-------~~~~l~~~l~~~l~~~~~~vr~~a~~~L~~l~~~~~~~~- 156 (657) T 4UQI_B 85 IMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDK-------ITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMV- 156 (657) T ss_pred HHHHHHHHHHhcCCCHHHHHHHHHHHhhcCCch-------hHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCHHHh- Confidence 445555666666677788888888888775421 112355666666777778888889988888875433221 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ....+++.+...+. +.++.++..++.++..+... T Consensus 157 --~~~~~~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~ 190 (657) T 4UQI_B 157 --EDQGFLDSLRDLIA-DSNPMVVANAVAALSEISES 190 (657) T ss_pred --cCcchHHHHHHHhc-CCCHHHHHHHHHHHHHHHhc Confidence 12245666777776 55678888899988888764 No 240 >5KC2_B Phosphatidylinositol 3-kinase VPS34 (E.C.2.7.1.137), Serine/threonine-protein; autophagy, phosphatidylinositol 3-kinase (PtdIns3K), endocytosis; 28.0A {Saccharomyces cerevisiae} Probab=94.04 E-value=0.0013 Score=79.08 Aligned_cols=155 Identities=11% Similarity=0.032 Sum_probs=110.7 Template_Neff=9.500 Q NP_000290.2 544 YHSDAIRTYLNLM---GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIG----------------------LKEKGLP 598 (747) Q Consensus 544 ve~G~I~~LL~LL---~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~ll----------------------ie~giI~ 598 (747) +..++++.|..++ . +.++.++..|+.+|..++..... ....+ ...++++ T Consensus 506 ~~~~~l~~L~~ll~~~~-d~~~~vR~~a~~~l~~la~~~~~-----~~~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~~ 579 (1454) T 5KC2_B 506 FVDYLLPRLKRLLISNR-QNTNYLRIVFANCLSDLAIIINR-----FQEFTFAQHCNDNSMDNNTEIMESSTKYSAKLIQ 579 (1454) T ss_pred HHcCcHHHHHHHHcCCC-CCcHHHHHHHHHHHHHHhcCCCC-----cceEEhhHHhhhHHHHHHHHHHHHHHHHHcCHHH Confidence 4667888899988 7 47788899999999988754221 01111 1245667 Q NP_000290.2 599 QIARLLQS----GNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ 674 (747) Q Consensus 599 ~Ll~LL~s----~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e 674 (747) .|..++.. .++.++..|+.+|..+.......... .++++.|..++.+ .++.++..|+.+|..|+... T Consensus 580 ~l~~ll~~~l~d~~~~vr~~a~~~l~~l~~~~~~~~~~-~~~l~~L~~~l~d------~~~~vR~~a~~al~~l~~~~-- 650 (1454) T 5KC2_B 580 SVEDLTVSFLTDNDTYVKMALLQNILPLCKFFGRERTN-DIILSHLITYLND------KDPALRVSLIQTISGISILL-- 650 (1454) T ss_pred HHHHHHHhhcCCCCHHHHHHHHHHHHHHhcCcCchhHH-hhhHHHHHHHccC------CCHHHHHHHHHHHHHHHHhh-- Confidence 77777765 78899999999999987652221111 4567888888876 47899999999999998743 Q NP_000290.2 675 LAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 675 ~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ....+++.. ++.|+.+|.+. ++.++..++.+|..|+... T Consensus 651 ~~~~~~~~~-lp~L~~lL~d~-~~~vr~~al~aL~~L~~~~ 689 (1454) T 5KC2_B 651 GTVTLEQYI-LPLLIQTITDS-EELVVISVLQSLKSLFKTG 689 (1454) T ss_pred HHHHHHHcC-HHHHHHHhcCC-CHHHHHHHHHHHHHHhhCC Confidence 333444433 88888888876 7888999999999887655 No 241 >3SL9_E Catenin beta-1, B-cell CLL/lymphoma 9; Armadillo repeat, components of the; HET: PEG, GOL, IMD, EDO; 2.2A {Homo sapiens} Probab=94.03 E-value=0.0012 Score=55.43 Aligned_cols=110 Identities=24% Similarity=0.309 Sum_probs=72.2 Template_Neff=12.600 Q NP_000290.2 246 TIPKAVQYLSS-QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~s-sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.. .+..++..++.++.+++.. ......+...++++.+..++...+..++..++.++.+++......... T Consensus 56 ~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~-~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~ 134 (167) T 3SL9_E 56 MVSAIVRTMQNTNDVETARCTAGTLHNLSHH-REGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMA 134 (167) T ss_dssp HHHHHHHHHHHCCCHHHHHHHHHHHHHHTTS-HHHHHHHHHTTHHHHHHHHTTCSSHHHHHHHHHHHHHHHHHCTTHHHH T ss_pred hHHHHHHHHhcCCCHHHHHHHHHHHHHHcCC-HhHHHHHHHCCcHHHHHHHhCCCCHHHHHHHHHHHHHHHcCCHhHHHH Confidence 55566666665 5667888888898888743 333333444567777888887777788888999998887654332222 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNL 357 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnL 357 (747) ....++++.+..++. ..++.++..++.++..+ T Consensus 135 ~~~~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l 166 (167) T 3SL9_E 135 VRLAGGLQKMVALLN-KTNVKFLAITTDCLQIL 166 (167) T ss_dssp HHHTTHHHHHHHHHH-HSCGGGHHHHHHHHHHH T ss_pred HHHcCHHHHHHHHhc-CCCHHHHHHHHHHHHHh Confidence 222456777777776 45566777777766654 No 242 >3VWA_B Cytoplasmic export protein 1; tRNA, nuclear export, HEAT repeat; HET: MSE; 2.2A {Saccharomyces cerevisiae} Probab=93.76 E-value=0.0017 Score=68.89 Aligned_cols=150 Identities=11% Similarity=0.077 Sum_probs=108.5 Template_Neff=10.700 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++++.++..+. +.++.++..++.+|..++..... . . ....+++.|..++.+.++.++..++.+|+.++.. T Consensus 379 ~~~l~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~------~-~-~~~~ll~~l~~~l~d~~~~vR~~a~~~l~~i~~~ 449 (560) T 3VWA_B 379 SRIYPHFIQGLT-DSDATLRLQTLKTIPCIVSCLTE------R-Q-LNNELLRFLAKTQVDSDVEIRTWTVIIISKISTI 449 (560) T ss_dssp CCCHHHHHHGGG-CSCHHHHHHHHHHHHHHGGGSCH------H-C-CCCCHHHHHHHHTTCSSHHHHHHHHHHHHHHHTT T ss_pred hchHHHHHHHhc-CCCHHHHHHHHHHHHHHHhhCCH------H-H-HHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHH Confidence 457788888887 47788999999999998864221 1 1 2356788888888888899999999999999876 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) ... .......+++.+...+.+ .++.++..|+.+|..++.... ... +...+++.|..++.+. +..++..| T Consensus 450 ~~~~~~~~~~~l~~~l~~~l~d------~~~~vR~aa~~~l~~~~~~~~--~~~-~~~~~lp~l~~~l~d~-~~~VR~~a 519 (560) T 3VWA_B 450 LSTSVGNRSNILATAFTKSLKD------PQVKPRLAALYGLEKSIELFD--VNT-IANKILTVIAPGLLDK-SPIVRGRA 519 (560) T ss_dssp SSSCHHHHHHHHHHHHHHHHTC------SSHHHHHHHHHHHHHTGGGSC--HHH-CCCCCHHHHGGGGGCS-SHHHHHHH T ss_pred hccccchhHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHCC--HHH-HHHHHHHHHHHHHCCC-CHHHHHHH Confidence 211 111123455666677765 478899999999999886422 112 2245788888888877 88999999 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.+|..++.. T Consensus 520 ~~~l~~~~~~ 529 (560) T 3VWA_B 520 KILFEEYLEK 529 (560) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 9999888754 No 243 >5DFZ_B Vacuolar protein sorting-associated protein 38; Vps34, Vps15, Vps30, Vps38, Autophagy; 4.4A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=93.74 E-value=0.0018 Score=77.73 Aligned_cols=155 Identities=10% Similarity=0.029 Sum_probs=111.5 Template_Neff=9.900 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++++.|+.+|. +.++.+|..|+.+|..+...... .. .....++.|+.++.+.++.++..|+.+|..+... T Consensus 608 ~~~l~~Li~ll~-d~~~~VR~~a~~aL~~i~~~~~~-------~~-~~~~~i~~L~~~l~d~~~~vR~~a~~aL~~~~~~ 678 (1460) T 5DFZ_B 608 DIILSHLITYLN-DKDPALRVSLIQTISGISILLGT-------VT-LEQYILPLLIQTITDSEELVVISVLQSLKSLFKT 678 (1460) T ss_pred HhHHHHHHHHhc-CCCHHHHHHHHHHHHHHHhhcCc-------hh-hchhHHHHHHHHhcCCCHHHHHHHHHHHHHhcCC Confidence 357888888888 57889999999999998864221 11 1234578888899988899999999999766543 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ......+..++++.|..++.+ .++.++..|+.+|..+....... .....+++.|+.++.+. ++.++..|+ T Consensus 679 ~~~~~~~~~~~i~~l~~~l~d------~~~~VR~~A~~al~~l~~~~~~~---~~~~~~l~~L~~~l~d~-~~~vr~~a~ 748 (1460) T 5DFZ_B 679 GLIRKKYYIDISKTTSPLLLH------PNNWIRQFTLMIIIEIINKLSKA---EVYCILYPIIRPFFEFD-VEFNFKSMI 748 (1460) T ss_pred cchhhcccchhHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhCCH---HHHHHHHHHHHHHhcCC-CHHHHHHHH Confidence 222111112367778888876 47889999999999987642111 11234688888888877 889999999 Q NP_000290.2 706 LLLSDMWSSKELQG 719 (747) Q Consensus 706 ~aLsnL~~~~~~~~ 719 (747) .+|..+..+...+- T Consensus 749 ~aL~~~~~~~~~~~ 762 (1460) T 5DFZ_B 749 SCCKQPVSRSVYNL 762 (1460) T ss_pred HHhCCCCCHHHHHH Confidence 99999887776664 No 244 >6HWP_A A3_bGFPD; alphaRep, artificial protein, chimera, bidomain; 2.547A {synthetic construct} Probab=93.71 E-value=0.0016 Score=62.80 Aligned_cols=91 Identities=14% Similarity=0.155 Sum_probs=54.4 Template_Neff=12.900 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) ..++.+...+.+.+..++..++..+..+.. ..+++.+...+.+.++.++..++..+..+.. T Consensus 23 ~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~-----------~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~-------- 83 (409) T 6HWP_A 23 EKVEMYIKNLQDDSYYVRRAAAYALGKIGD-----------ERAVEPLIKALKDEDAWVRRAAADALGQIGD-------- 83 (409) T ss_dssp CCHHHHHHGGGCSSHHHHHHHHHHHHHSCC-----------GGGHHHHHHHTTCSSHHHHHHHHHHHHHHTC-------- T ss_pred HHHHHHHHHccCCCHHHHHHHHHHHHHhcC-----------HhhHHHHHHHhcCCCHHHHHHHHHHHHHhcC-------- Confidence 445556666666677778888877776643 1234445555556667777777777766543 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++.+...+. +.++.++..++.++..+. T Consensus 84 ---~~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~ 113 (409) T 6HWP_A 84 ---ERAVEPLIKALK-DEDGWVRQSAAVALGQIG 113 (409) T ss_dssp ---GGGHHHHHHHTT-CSSHHHHHHHHHHHHHHT T ss_pred ---HhhHHHHHHHhc-CCCHHHHHHHHHHHHHHC Confidence 123344445554 445566666666666554 No 245 >3TT9_A Plakophilin-2; CELL ADHESION; HET: GOL; 1.55A {Homo sapiens} Probab=93.69 E-value=0.0017 Score=58.18 Aligned_cols=169 Identities=18% Similarity=0.246 Sum_probs=122.4 Template_Neff=12.300 Q NP_000290.2 542 WLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLS 620 (747) Q Consensus 542 ~lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-s~d~eVr~~AL~aLs 620 (747) .+++.|+++.|+.++. ..++.++..++++|.+++...+. ....+.+.++++.|+.++. ..+..++..++++|. T Consensus 47 ~~~~~~~i~~l~~~l~-~~~~~~~~~a~~~L~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~ 120 (233) T 3TT9_A 47 RVNQLRGILKLLQLLK-VQNEDVQRAVCGALRNLVFEDND-----NKLEVAELNGVPRLLQVLKQTRDLETKKQITGLLW 120 (233) T ss_dssp HHHHTTHHHHHHHGGG-CCCHHHHHHHHHHHHHHHTTCHH-----HHHHHHHTTHHHHHHHHHHHCCCHHHHHHHHHHHH T ss_pred HHHHcchHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCCc-----HHHHHHHcccHHHHHHHHhhCCCHHHHHHHHHHHH Confidence 3467788999999998 46778889999999999874332 2444456789999999998 567889999999999 Q NP_000290.2 621 NMSRHPLL-HRVMGNQVFPEVTRLLTSHTGN---------TSNSEDILSSACYTVRNLMASQPQLAKQYFSSSM-LNNII 689 (747) Q Consensus 621 nLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~---------~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~gi-L~~Ll 689 (747) +++..... ..+...+++..+..++...... ...+..++..++++|.+++...+.....+.+.+. ++.|+ T Consensus 121 ~l~~~~~~~~~~~~~~~~~~l~~ll~~~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~l~ 200 (233) T 3TT9_A 121 NLSSNDKLKNLMITEALLTLTENIIIPFSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGADGRKAMRRCDGLIDSLV 200 (233) T ss_dssp HHHTSGGGHHHHHHHHHHHHCCCCCHHHHCCCGGGCCCCCTTCCHHHHHHHHHHHHHHTTSCHHHHHHHHTSTTHHHHHH T ss_pred HHccCHHHHHHhhhhcHHHHHHHHHhhccCCCCCCCCcccCCCcHHHHHHHHHHHHHHHhcCHHHHHHHHHcccHHHHHH Confidence 99876433 3334455666666665431000 0014677889999999999855666666776666 88888 Q NP_000290.2 690 NLCRSSA-----SPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 690 ~LL~s~~-----d~eVr~aAL~aLsnL~~~~~ 716 (747) .++.... ++.++..++++|.+|+...+ T Consensus 201 ~~l~~~~~~~~~~~~~~~~~~~~L~~l~~~~~ 232 (233) T 3TT9_A 201 HYVRGTIADYQPDDKATENCVCILHNLSYQLE 232 (233) T ss_dssp HHHHHHHHTTCTTCHHHHHHHHHHHHHCCCCC T ss_pred HHHHcccccCCCChHHHHHHHHHHHHhhhccc Confidence 8887542 46788899999999887654 No 246 >3VWA_A Cytoplasmic export protein 1; tRNA, nuclear export, HEAT repeat; 2.2A {Saccharomyces cerevisiae} Probab=93.63 E-value=0.0019 Score=68.57 Aligned_cols=152 Identities=11% Similarity=0.067 Sum_probs=108.9 Template_Neff=10.600 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++++.++..+. +.++.++..++.+|..++...+. . . ....+++.|..++.+.++.++..++.+|..++. T Consensus 378 ~~~~~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~------~-~-~~~~ll~~l~~~l~d~~~~vR~~a~~~l~~i~~ 448 (560) T 3VWA_A 378 SSRIYPHFIQGLT-DSDATLRLQTLKTIPCIVSCLTE------R-Q-LNNELLRFLAKTQVDSDVEIRTWTVIIISKIST 448 (560) T ss_dssp CCCCHHHHHHGGG-CSSHHHHHHHHHHHHHHGGGCCH------H-C-CCCCCHHHHHHHTTCSSHHHHHHHHHHHHHHGG T ss_pred HhchHHHHHHHhc-CCCHHHHHHHHHHHHHHHhhCCH------H-H-HHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHH Confidence 3457888888887 47788999999999988864321 1 1 235678888888888889999999999999987 Q NP_000290.2 625 HPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 625 ~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) .... .......+++.+...+.+ .++.++..|+.+|..++.... ...+ ...+++.+..++.+. +..++.. T Consensus 449 ~~~~~~~~~~~~l~~~l~~~l~d------~~~~vR~~a~~~l~~~~~~~~--~~~~-~~~ilp~l~~ll~d~-~~~VR~~ 518 (560) T 3VWA_A 449 ILSTSVGNRSNILATAFTKSLKD------PQVKPRLAALYGLEKSIELFD--VNTI-ANKILTVIAPGLLDK-SPIVRGR 518 (560) T ss_dssp GSSSCHHHHHHHHHHHHHHHHTC------SSHHHHHHHHHHHHHTGGGSC--HHHC-CCCCHHHHGGGGGCS-SHHHHHH T ss_pred HhccchhhhHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHCC--HHHH-HHHHHHHHHHHHCCC-CHHHHHH Confidence 6211 111223455666677765 378899999999999886422 1122 235688888888877 8899999 Q NP_000290.2 704 ARLLLSDMWSSK 715 (747) Q Consensus 704 AL~aLsnL~~~~ 715 (747) |+.+|..+...- T Consensus 519 a~~~l~~i~~~l 530 (560) T 3VWA_A 519 AKILFEEYLEKL 530 (560) T ss_dssp HHHHHHHHHHHH T ss_pred HHHHHHHHHHHH Confidence 999988877543 No 247 >1XQR_A HspBP1 protein; armadillo repeat, superhelical twist, CHAPERONE; HET: MSE; 2.1A {Homo sapiens} SCOP: a.118.1.21 Probab=93.61 E-value=0.0019 Score=61.69 Aligned_cols=122 Identities=15% Similarity=0.146 Sum_probs=77.8 Template_Neff=11.300 Q NP_000290.2 257 QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVD-LLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAV 335 (747) Q Consensus 257 sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~-lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll 335 (747) .++.++..++..|..++.. ......+...++++.++. ++...++.++..++.++.+++.........+...++++.+. T Consensus 52 ~~~~~~~~al~~L~~l~~~-~~~~~~~~~~~~~~~l~~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~l~~~~~~~~l~ 130 (296) T 1XQR_A 52 ADQQEREGALELLADLCEN-MDNAADFCQLSGMHLLVGRYLEAGAAGLRWRAAQLIGTCSQNVAAIQEQVLGLGALRKLL 130 (296) T ss_dssp HHHHHHHHHHHHHHHHHTS-HHHHHHHHHTTHHHHCCCCCTTCSSHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHH T ss_pred CCHHHHHHHHHHHHHHHcC-HHHHHHHHHcccHHHHHHHHHhCCCHHHHHHHHHHHHHHhcCCHHHHHHHHhCCHHHHHH Confidence 4456777788888887764 333334445566777777 77776778888999999998865443333344445777777 Q NP_000290.2 336 SLLRRTG-NAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 336 ~lL~ss~-d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) .++. .. ++.++..++.++.+++..... ...+.. ++++.|+.++. T Consensus 131 ~~l~-~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~i~~l~~~l~ 177 (296) T 1XQR_A 131 RLLD-RDACDTVRVKALFAISCLVREQEAGLLQFLRLDGFSVLMRAMQ 177 (296) T ss_dssp HHHH-HCSCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHH T ss_pred HHHh-cCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhh Confidence 7776 33 567788888888888764322 222222 45555555543 No 248 >1XQS_B HSPBP1 protein, Heat shock 70; armadillo repeat, superhelical twist, CHAPERONE; HET: AMP; 2.9A {Homo sapiens} SCOP: a.118.1.21 Probab=93.37 E-value=0.0023 Score=59.66 Aligned_cols=123 Identities=15% Similarity=0.159 Sum_probs=77.3 Template_Neff=11.900 Q NP_000290.2 257 QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVD-LLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAV 335 (747) Q Consensus 257 sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~-lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll 335 (747) .+..++..++..|..++.. ......+...++++.++. ++...+..++..++.++..++.........+...++++.+. T Consensus 36 ~~~~~~~~al~~L~~l~~~-~~~~~~~~~~~~i~~l~~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~ 114 (280) T 1XQS_B 36 ADQQEREGALELLADLCEN-MDNAADFCQLSGMHLLVGRYLEAGAAGLRWRAAQLIGTCSQNVAAIQEQVLGLGALRKLL 114 (280) T ss_dssp HHHHHHHHHHHHHHHHHTS-HHHHHHHHHTTHHHHCCCCCTSCSCHHHHHHHHHHHHHHHTTCHHHHHHHHTTTHHHHHH T ss_pred cCHHHHHHHHHHHHHHHhc-HHHHHHHHHcccHHHHHHHHhhcCCHHHHHHHHHHHHHHccCCHHHHHHHHHCCHHHHHH Confidence 4466777888888888654 233334445567777777 77766778888899999998865443333444445777777 Q NP_000290.2 336 SLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 336 ~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) .++....++.++..++.++.+++..... ...+.. ++++.|+.++. T Consensus 115 ~~l~~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 161 (280) T 1XQS_B 115 RLLDRDACDTVRVKALFAISCLVREQEAGLLQFLRLDGFSVLMRAMQ 161 (280) T ss_dssp HHHHSCSCHHHHHHHHHHHHHTTSSCHHHHHHHHTTTHHHHHHHHHT T ss_pred HHhccCCCHHHHHHHHHHHHHHHhcCHHHHHHHHHCCHHHHHHHHhh Confidence 7775222566777888888888764322 222222 44555554443 No 249 >5VOZ_P V-type proton ATPase catalytic subunit; V-ATPase, SidK, rotational state 3;{Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=93.32 E-value=0.0027 Score=67.46 Aligned_cols=330 Identities=11% Similarity=0.063 Sum_probs=181.1 Template_Neff=8.900 Q NP_000290.2 290 CKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTN---KLETR---RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 290 ~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~---~~~ll---~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~ 362 (747) ..++.++.. .+.++...++.++..++...+ . ...++ ..+.++.++.++. . ++.++..++.+|..++... T Consensus 78 ~~li~LL~~~~~~d~~~~~l~~l~~ll~~~~-~~~~r~~~~~~~~~~~~~~li~lL~-~-d~~i~~~a~~~L~~L~~~~- 153 (478) T 5VOZ_P 78 IPLIHLLSTSDNEDCKKSVQNLIAELLSSDK-YGDDTVKFFQEDPKQLEQLFDVSLK-G-DFQTVLISGFNVVSLLVQN- 153 (478) T ss_dssp HHHHHHHHHCCCHHHHHHHHHHHHHHHHCSS-SCHHHHHHHHHCTHHHHHHTTSTTS-S-CHHHHHHHHHHHHHHHTSS- T ss_pred HHHHHHHccCCCHHHHHHHHHHHHHHHcCCC-CccchhHHhccChhhHHHHHHHHcC-C-CHHHHHHHHHHHHHHHHhc- Confidence 556666654 466777788888888876544 3 22233 2456778888886 5 6677888888888887654 Q NP_000290.2 363 LK-EELIA-DALPV--LADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSAD 438 (747) Q Consensus 363 ~~-~~Lve-giLe~--Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 438 (747) .. ..... ++++. ++.+|. ++ -++++-..|..||..-+. .+ T Consensus 154 ~~~~~~~~~~~l~~~~li~~L~---------~~------~~~~~~~~a~~~L~~L~~---------------------~~ 197 (478) T 5VOZ_P 154 GLHNVKLVEKLLKNNNLINILQ---------NI------EQMDTCYVCIRLLQELAV---------------------IP 197 (478) T ss_dssp SCCCHHHHHHHHSSHHHHHHHH---------CS------SCHHHHHHHHHHHHHHTT---------------------SH T ss_pred cccCcccchhhcccchHHHHHh---------cc------CCccHHHHHHHHHHHHcC---------------------Ch Confidence 32 11122 66776 777761 11 123444555555533211 11 Q NP_000290.2 439 AGRQTMRNY-SGLIDSLMAYVQNCVAA-----------SRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYT 506 (747) Q Consensus 439 ~~~~~~~~~-~~~~~~~~~~~~~~~~~-----------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 506 (747) ..|...... .|.|..|...+.+.... ...+..-..++...|.+|++ T Consensus 198 ~~r~~~~~~~~g~i~~Lv~lL~~~~~~~~~~~~~~~~~~~~~~ql~~~a~~~L~~Ls~---------------------- 255 (478) T 5VOZ_P 198 EYRDVIWLHEKKFMPTLFKILQRATDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTF---------------------- 255 (478) T ss_dssp HHHHHHHHSTTSSHHHHHHHHHHHHHSCSSCCCTTTSSSHHHHHHHHHHHHHHHHHTT---------------------- T ss_pred HHHHHHHHccccchHHHHHHHHhccccccccccccccCcCcCHHHHHHHHHHHHHHhc---------------------- Confidence 122222221 34455555444432110 00111111222222233322 Q NP_000290.2 507 EKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHS--DAIRTYLNLMGKSKK-DATLEACAGALQNLTASKGLMS 583 (747) Q Consensus 507 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~--G~I~~LL~LL~ss~d-~eVr~~AL~aL~nLs~~s~~~s 583 (747) +......+.+. ++++.|+.+++. .. +.++..++.+|.+++...+. T Consensus 256 -----------------------------~~~~~~~l~~~~~~~i~~Lv~ll~~-~~kekv~r~al~~L~nL~~~~~~-- 303 (478) T 5VOZ_P 256 -----------------------------NPVFANELVQKYLSDFLDLLKLVKI-TIKEKVSRLCISIILQCCSTRVK-- 303 (478) T ss_dssp -----------------------------SHHHHHHHHHHSHHHHGGGHHHHHH-CCCHHHHHHHHHHHHHHTSTTST-- T ss_pred -----------------------------CHHHHHHHHHHhHHHHHHHHHHHhc-cchHHHHHHHHHHHHHHhccChH-- Confidence 00111223444 789999999984 44 67888899999999875321 Q NP_000290.2 584 SG-MSQLIGLKEKGLPQIARLLQSG---NSDVVRSGASLLSNMSRH-------P------------------------LL 628 (747) Q Consensus 584 ~~-~~~~llie~giI~~Ll~LL~s~---d~eVr~~AL~aLsnLa~~-------~------------------------e~ 628 (747) .. .....+...+.+..++..|... +++++..+..++..+... + +. T Consensus 304 ~~~~~~~~l~~~~~~l~ll~~L~~~~~~d~~l~~~l~~l~~~L~~~~~~lss~dey~~el~sg~l~wsp~h~s~~f~~~n 383 (478) T 5VOZ_P 304 QHKKVIKQLLLLGNALPTVQSLSERKYSDEELRQDISNLKEILENEYQELTSFDEYVAELDSKLLCWSPPHVDNGFWSDN 383 (478) T ss_dssp THHHHHHHCCCCCCHHHHHHHHTSCCCSCTHHHHHHHHHHHHHHHHHHTSCHHHHHHHHHHHTCCCCCTTTTCHHHHHHH T ss_pred hcHHHHHHHHHcCCHHHHHHHHHhCCCCcHHHHHHHHHHHHHHHHHHhhcCCHHHHHHHHHcCCCCCCCCcCCcChHHHh Confidence 00 0012333444344566666543 444544433333333100 0 01 Q NP_000290.2 629 -HRVM--GNQVFPEVTRLLTSHTGNT----SNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAA 701 (747) Q Consensus 629 -~~ll--~~giI~~Ll~LL~s~s~~~----~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr 701 (747) ..+. ..++++.|+.+|....... ..+..++..++..|++++...+.....+.+.++++.|+.++.+. ++.++ T Consensus 384 ~~~~~~~~~~~l~~Lv~lL~~~~~~~~~~~~~~~~v~~~a~~~l~~lv~~~~~~~~~l~~~g~~~~L~~Ll~~~-~~~vr 462 (478) T 5VOZ_P 384 IDEFKKDNYKIFRQLIELLQAKVRNGDVNAKQEKIIIQVALNDITHVVELLPESIDVLDKTGGKADIMELLNHS-DSRVK 462 (478) T ss_dssp HHHHTTSSSHHHHHHHHHHHHHHHSSCSSSHHHHHHHHHHHHHHHHHHHHCTTTHHHHHHHTCHHHHHHHHTSS-CHHHH T ss_pred HHHhhhccHHHHHHHHHHHHhhhhCCCCCccccHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHhcCC-CHHHH Confidence 0111 2457788888886510000 01244577788899999665566666677778899999999877 88999 Q NP_000290.2 702 EAARLLLSDMWSS 714 (747) Q Consensus 702 ~aAL~aLsnL~~~ 714 (747) ..|+.++.+++.+ T Consensus 463 ~~Al~al~~l~~~ 475 (478) T 5VOZ_P 463 YEALKATQAIIGY 475 (478) T ss_dssp HHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhh Confidence 9999999988754 No 250 >5D80_H V-type proton ATPase catalytic subunit; Hydrolase, Autoinhibition; 6.202A {Saccharomyces cerevisiae} Probab=93.32 E-value=0.0027 Score=67.46 Aligned_cols=330 Identities=11% Similarity=0.063 Sum_probs=181.1 Template_Neff=8.900 Q NP_000290.2 290 CKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTN---KLETR---RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE 362 (747) Q Consensus 290 ~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~---~~~ll---~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~ 362 (747) ..++.++.. .+.++...++.++..++...+ . ...++ ..+.++.++.++. . ++.++..++.+|..++... T Consensus 78 ~~li~LL~~~~~~d~~~~~l~~l~~ll~~~~-~~~~r~~~~~~~~~~~~~~li~lL~-~-d~~i~~~a~~~L~~L~~~~- 153 (478) T 5D80_H 78 IPLIHLLSTSDNEDCKKSVQNLIAELLSSDK-YGDDTVKFFQEDPKQLEQLFDVSLK-G-DFQTVLISGFNVVSLLVQN- 153 (478) T ss_pred HHHHHHHccCCCHHHHHHHHHHHHHHHcCCC-CccchhHHhccChhhHHHHHHHHcC-C-CHHHHHHHHHHHHHHHHhc- Confidence 556666654 466777788888888876544 3 22233 2456778888886 5 6677888888888887654 Q NP_000290.2 363 LK-EELIA-DALPV--LADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSAD 438 (747) Q Consensus 363 ~~-~~Lve-giLe~--Lv~LL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 438 (747) .. ..... ++++. ++.+|. ++ -++++-..|..||..-+. .+ T Consensus 154 ~~~~~~~~~~~l~~~~li~~L~---------~~------~~~~~~~~a~~~L~~L~~---------------------~~ 197 (478) T 5D80_H 154 GLHNVKLVEKLLKNNNLINILQ---------NI------EQMDTCYVCIRLLQELAV---------------------IP 197 (478) T ss_pred cccCcccchhhcccchHHHHHh---------cc------CCccHHHHHHHHHHHHcC---------------------Ch Confidence 32 11122 66776 777761 11 123444555555533211 11 Q NP_000290.2 439 AGRQTMRNY-SGLIDSLMAYVQNCVAA-----------SRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYT 506 (747) Q Consensus 439 ~~~~~~~~~-~~~~~~~~~~~~~~~~~-----------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 506 (747) ..|...... .|.|..|...+.+.... ...+..-..++...|.+|++ T Consensus 198 ~~r~~~~~~~~g~i~~Lv~lL~~~~~~~~~~~~~~~~~~~~~~ql~~~a~~~L~~Ls~---------------------- 255 (478) T 5D80_H 198 EYRDVIWLHEKKFMPTLFKILQRATDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTF---------------------- 255 (478) T ss_pred HHHHHHHHccccchHHHHHHHHhccccccccccccccCcCcCHHHHHHHHHHHHHHhc---------------------- Confidence 122222221 34455555444432110 00111111222222233322 Q NP_000290.2 507 EKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHS--DAIRTYLNLMGKSKK-DATLEACAGALQNLTASKGLMS 583 (747) Q Consensus 507 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~lve~--G~I~~LL~LL~ss~d-~eVr~~AL~aL~nLs~~s~~~s 583 (747) +......+.+. ++++.|+.+++. .. +.++..++.+|.+++...+. T Consensus 256 -----------------------------~~~~~~~l~~~~~~~i~~Lv~ll~~-~~kekv~r~al~~L~nL~~~~~~-- 303 (478) T 5D80_H 256 -----------------------------NPVFANELVQKYLSDFLDLLKLVKI-TIKEKVSRLCISIILQCCSTRVK-- 303 (478) T ss_pred -----------------------------CHHHHHHHHHHhHHHHHHHHHHHhc-cchHHHHHHHHHHHHHHhccChH-- Confidence 00111223444 789999999984 44 67888899999999875321 Q NP_000290.2 584 SG-MSQLIGLKEKGLPQIARLLQSG---NSDVVRSGASLLSNMSRH-------P------------------------LL 628 (747) Q Consensus 584 ~~-~~~~llie~giI~~Ll~LL~s~---d~eVr~~AL~aLsnLa~~-------~------------------------e~ 628 (747) .. .....+...+.+..++..|... +++++..+..++..+... + +. T Consensus 304 ~~~~~~~~l~~~~~~l~ll~~L~~~~~~d~~l~~~l~~l~~~L~~~~~~lss~dey~~el~sg~l~wsp~h~s~~f~~~n 383 (478) T 5D80_H 304 QHKKVIKQLLLLGNALPTVQSLSERKYSDEELRQDISNLKEILENEYQELTSFDEYVAELDSKLLCWSPPHVDNGFWSDN 383 (478) T ss_pred hcHHHHHHHHHcCCHHHHHHHHHhCCCCcHHHHHHHHHHHHHHHHHHhhcCCHHHHHHHHHcCCCCCCCCcCCcChHHHh Confidence 00 0012333444344566666543 444544433333333100 0 01 Q NP_000290.2 629 -HRVM--GNQVFPEVTRLLTSHTGNT----SNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAA 701 (747) Q Consensus 629 -~~ll--~~giI~~Ll~LL~s~s~~~----~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr 701 (747) ..+. ..++++.|+.+|....... ..+..++..++..|++++...+.....+.+.++++.|+.++.+. ++.++ T Consensus 384 ~~~~~~~~~~~l~~Lv~lL~~~~~~~~~~~~~~~~v~~~a~~~l~~lv~~~~~~~~~l~~~g~~~~L~~Ll~~~-~~~vr 462 (478) T 5D80_H 384 IDEFKKDNYKIFRQLIELLQAKVRNGDVNAKQEKIIIQVALNDITHVVELLPESIDVLDKTGGKADIMELLNHS-DSRVK 462 (478) T ss_pred HHHhhhccHHHHHHHHHHHHhhhhCCCCCccccHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHhcCC-CHHHH Confidence 0111 2457788888886510000 01244577788899999665566666677778899999999877 88999 Q NP_000290.2 702 EAARLLLSDMWSS 714 (747) Q Consensus 702 ~aAL~aLsnL~~~ 714 (747) ..|+.++.+++.+ T Consensus 463 ~~Al~al~~l~~~ 475 (478) T 5D80_H 463 YEALKATQAIIGY 475 (478) T ss_pred HHHHHHHHHHHhh Confidence 9999999988754 No 251 >1F59_B IMPORTIN BETA-1/FXFG NUCLEOPORIN; Protein-protein complex, TRANSPORT PROTEIN RECEPTOR; 2.8A {Homo sapiens} SCOP: a.118.1.1 Probab=93.26 E-value=0.0024 Score=62.21 Aligned_cols=154 Identities=10% Similarity=0.056 Sum_probs=84.6 Template_Neff=12.900 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLM------------SSGMSQLIG---LKEKGLPQIARLLQSG------ 607 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~------------s~~~~~~ll---ie~giI~~Ll~LL~s~------ 607 (747) ++.++.++. +.++.++..++.++..++...... ......... .-..+++.+...+... T Consensus 261 ~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~l~~~~~~~~~ 339 (442) T 1F59_B 261 FAITIEAMK-SDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDD 339 (442) T ss_dssp HHHHHHHHH-SSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHGGGTSCCSSCCCCHHHHHHHHHHHHHHHHTTCCCCCCCS T ss_pred HHHHHHHhc-CCcHHHHHHHHHHHHHHhhHHHHHHHHHHHHHhcCCCCchhhhHHHHHHHHHHHHHHHHHHccCCCCCCC Confidence 455666666 356677777888887776531000 000000000 0122344444444332 Q NP_000290.2 608 -NSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSML 685 (747) Q Consensus 608 -d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~giL 685 (747) +..++..+..++..+...... .....+++.+...+.+ .++.++..++.++..+....+. ...... ..++ T Consensus 340 ~~~~~r~~a~~~l~~l~~~~~~--~~~~~~~~~l~~~l~~------~~~~~r~~al~~l~~l~~~~~~~~~~~~~-~~~~ 410 (442) T 1F59_B 340 DDWNPCKAAGVCLMLLATCCED--DIVPHVLPFIKEHIKN------PDWRYRDAAVMAFGCILEGPEPSQLKPLV-IQAM 410 (442) T ss_dssp SCCCHHHHHHHHHHHHHHHSTT--THHHHHHHHHHHHTTC------SSHHHHHHHHHHHHHHTSSSCHHHHHHHH-HTTH T ss_pred CCCcHHHHHHHHHHHHHHhccc--ccHHhHHHHHHHHhcC------CChHHHHHHHHHHHHHHhCCCHHHHHHHH-HHHH Confidence 345667777777777654111 1112244445555544 3677888999999988865332 111111 2456 Q NP_000290.2 686 NNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 686 ~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) +.+...+.+. ++.++..++++|..++. T Consensus 411 ~~l~~~l~d~-~~~vr~~a~~~l~~l~~ 437 (442) T 1F59_B 411 PTLIELMKDP-SVVVRDTAAWTVGRICE 437 (442) T ss_dssp HHHHHHTTCS-CSHHHHHHHHHHHHHHH T ss_pred HHHHHHhcCC-CHHHHHHHHHHHHHHHH Confidence 6677777665 78899999999988764 No 252 >6XTE_A Importin-5, antipain; human karyopherin, PA-PB1 sub-complex nuclear; HET: FC0, OAR; 2.27A {Homo sapiens} Probab=93.23 E-value=0.0025 Score=70.44 Aligned_cols=153 Identities=9% Similarity=0.114 Sum_probs=85.8 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) .++.+...+. +.++.++..++.++..++..... .... .-..+++.+...+.+.++.++..++.++..++.. . T Consensus 358 l~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 430 (1096) T 6XTE_A 358 IKEHIMQMLQ-NPDWKYRHAGLMALSAIGEGCHQ-----QMEG-ILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFA 430 (1096) T ss_dssp HHHHHHHHHT-CSSHHHHHHHHHHHHHTHHHHTT-----TTTT-THHHHHHHHHHGGGCSSHHHHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhhHH-----HHHH-HHHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHhcc Confidence 3444555555 35677788888888887764221 0111 1134566677777777888999999999998865 2 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSMLNNIINL--------CRSSA 696 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~giL~~Ll~L--------L~s~~ 696 (747) .. .......+++.+...+.+. .+..++..++.+|..++...+. .....+ ..++..+... +.+. T Consensus 431 ~~~~~~~~~~~~~~l~~~l~~~-----~~~~v~~~a~~~l~~l~~~~~~~~~~~~~-~~~~~~l~~~l~~~~~~~~~~~- 503 (1096) T 6XTE_A 431 PGFQKKFHEKVIAALLQTMEDQ-----GNQRVQAHAAAALINFTEDCPKSLLIPYL-DNLVKHLHSIMVLKLQELIQKG- 503 (1096) T ss_dssp THHHHHHHHHHHHHHHHHHHTC-----SCHHHHHHHHHHHHHHHHTSCHHHHGGGH-HHHHHHHHHHHHHHHHHHHHTC- T ss_pred HHHHHHHHHHHHHHHHHHhccc-----CCHHHHHHHHHHHHHHhccCCHHhHHHHH-HHHHHHHHHHHHHHHHHHHHcC- Confidence 11 1111233555566655541 2467788888888888764322 111111 1223333322 2222 Q NP_000290.2 697 SPKAAEAARLLLSDMWSS 714 (747) Q Consensus 697 d~eVr~aAL~aLsnL~~~ 714 (747) +..++..++.++..++.. T Consensus 504 ~~~~~~~~~~~l~~l~~~ 521 (1096) T 6XTE_A 504 TKLVLEQVVTSIASVADT 521 (1096) T ss_dssp CCHHHHHHHHHHHHHHHH T ss_pred CHhHHHHHHHHHHHHHHH Confidence 456677777777766643 No 253 >4HXT_A De Novo Protein OR329; Structural Genomics, PSI-Biology, Protein Structure; 1.95A {artificial gene} Probab=93.20 E-value=0.0025 Score=56.21 Aligned_cols=134 Identities=25% Similarity=0.298 Sum_probs=86.9 Template_Neff=13.200 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++.++.+++...+.....+...++++.+...+.+.++.++..++.++..++.......... T Consensus 87 ~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 166 (252) T 4HXT_A 87 GVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAI 166 (252) T ss_dssp HHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTSCHHHHHHH T ss_pred hHHHHHHHccCCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhhCCCHHHHHHHHHHHHHHHcCCHHHHHHH Confidence 44556666666677788888999988876543333333334567777777776677888889999988876543332333 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDEL-KEELIA-DALPVLADRVI 380 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~-~~~Lve-giLe~Lv~LL~ 380 (747) ...++++.+...+. ..++.++..++.++..++..... ...+.. ++++.+..++. T Consensus 167 ~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~ 222 (252) T 4HXT_A 167 VDAGGVEVLVKLLT-STDSEVQKEAARALANIASGPTSAIKAIVDAGGVEVLQKLLT 222 (252) T ss_dssp HHTTHHHHHHHHTT-CSCHHHHHHHHHHHHHHTTSBHHHHHHHHHTTHHHHHHHGGG T ss_pred HHCCHHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhc Confidence 33456777777776 55677888889999888864322 222223 56666666654 No 254 >5IFE_C Splicing factor 3B subunit 5; pre-mRNA splicing, U2 snRNP, essential; 3.1A {Homo sapiens} Probab=93.19 E-value=0.0029 Score=75.01 Aligned_cols=153 Identities=10% Similarity=0.044 Sum_probs=93.2 Template_Neff=9.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.|...+. +.+..++..++.+|..++..... . .... ....++..|...+.+.++.++..++.+|..++.... T Consensus 932 l~~~L~~~L~-~~~~~vR~~A~~~L~~l~~~~~~---~-~~~~-~~~~l~~~L~~~L~d~~~~vr~~al~aL~~l~~~~~ 1005 (1304) T 5IFE_C 932 ICGTVLWRLN-NKSAKVRQQAADLISRTAVVMKT---C-QEEK-LMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIG 1005 (1304) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhccC---c-CHHH-HHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhhC Confidence 4566666676 46678888999999988754221 0 0011 123456677777777777888888888888876521 Q NP_000290.2 628 L---HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 628 ~---~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . ...+ ..+++.|..++.+ .+..++..++.+|..++...+.....-.-..++..++..+.+. +..++..+ T Consensus 1006 ~~~l~~~l-~~ll~~L~~~L~~------~~~~Vr~~ai~~L~~i~~~~~~~~~~~~~~~il~~Ll~~l~~~-~~~vr~~a 1077 (1304) T 5IFE_C 1006 MHKMTPPI-KDLLPRLTPILKN------RHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAH-KKAIRRAT 1077 (1304) T ss_pred hHHhcccH-HhHHHHHHHHhCC------CCHHHHHHHHHHHHHHHhcCcccCCHHHHHhhHHHHHHHccCC-CHHHHHHH Confidence 1 1112 2456666677665 3577888899999888764322111000012344455555544 66788888 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.+|..++.. T Consensus 1078 ~~~L~~l~~~ 1087 (1304) T 5IFE_C 1078 VNTFGYIAKA 1087 (1304) T ss_pred HHHHHHHHHH Confidence 8888877653 No 255 >6AHD_1 Pre-mRNA-processing-splicing factor 8, Thioredoxin-like protein; Spliceosome, SPLICING; HET: IHP, GTP; 3.8A {Homo sapiens} Probab=93.19 E-value=0.0029 Score=75.01 Aligned_cols=153 Identities=10% Similarity=0.044 Sum_probs=93.2 Template_Neff=9.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.|...+. +.+..++..++.+|..++..... . .... ....++..|...+.+.++.++..++.+|..++.... T Consensus 932 l~~~L~~~L~-~~~~~vR~~A~~~L~~l~~~~~~---~-~~~~-~~~~l~~~L~~~L~d~~~~vr~~al~aL~~l~~~~~ 1005 (1304) T 6AHD_1 932 ICGTVLWRLN-NKSAKVRQQAADLISRTAVVMKT---C-QEEK-LMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIG 1005 (1304) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhccC---c-CHHH-HHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhhC Confidence 4566666676 46678888999999988754221 0 0011 123456677777777777888888888888876521 Q NP_000290.2 628 L---HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 628 ~---~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . ...+ ..+++.|..++.+ .+..++..++.+|..++...+.....-.-..++..++..+.+. +..++..+ T Consensus 1006 ~~~l~~~l-~~ll~~L~~~L~~------~~~~Vr~~ai~~L~~i~~~~~~~~~~~~~~~il~~Ll~~l~~~-~~~vr~~a 1077 (1304) T 6AHD_1 1006 MHKMTPPI-KDLLPRLTPILKN------RHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAH-KKAIRRAT 1077 (1304) T ss_pred hHHhcccH-HhHHHHHHHHhCC------CCHHHHHHHHHHHHHHHhcCcccCCHHHHHhhHHHHHHHccCC-CHHHHHHH Confidence 1 1112 2456666677665 3577888899999888764322111000012344455555544 66788888 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.+|..++.. T Consensus 1078 ~~~L~~l~~~ 1087 (1304) T 6AHD_1 1078 VNTFGYIAKA 1087 (1304) T ss_pred HHHHHHHHHH Confidence 8888877653 No 256 >6QH5_B AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=93.12 E-value=0.0027 Score=64.56 Aligned_cols=146 Identities=10% Similarity=-0.008 Sum_probs=87.6 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.++..+....++.++..++.+|..+..... . ....++.+...+.+.+..++..++.++..+..... T Consensus 428 ~~~~l~~~l~~~~~~~vr~~a~~~l~~~~~~~~-------~----~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 496 (592) T 6QH5_B 428 IIATLCENLDSLDEPDARAAMIWIVGEYAERID-------N----ADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKP 496 (592) T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHHHhCC-------C----hhhHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhCC Confidence 556666666522456777788888887765311 0 13456667777777778899999999998876521 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) .. +...+...+..++.+. .++.++..+..++..+.... ......+. ..++.++..+.+. ++.++..++.+ T Consensus 497 ~~--~~~~l~~~l~~~~~~~-----~~~~vr~~a~~~l~~l~~~~-~~~~~~~~-~~~~~l~~~~~~~-~~~~~~~~~~~ 566 (592) T 6QH5_B 497 SE--TQELVQQVLSLATQDS-----DNPDLRDRGYIYWRLLSTDP-VTAKEVVL-SEKPLISEETDLI-EPTLLDELICH 566 (592) T ss_pred HH--hhhhhHHHHHHHcCCC-----CCHHHHHHHHHHHHHHhcCc-hhhHHHHH-hhHHHHHHHcCCC-CHHHHHHHHHH Confidence 10 1111222222323331 25678888888888876542 21112221 2356666666555 67888888888 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) |..+... T Consensus 567 l~~l~~~ 573 (592) T 6QH5_B 567 IGSLASV 573 (592) T ss_pred HHHHHHH Confidence 8877653 No 257 >6EN4_C Splicing factor 3B subunit 3; Protein complex, splicing modulator, SPLICING; HET: BGZ; 3.08A {Homo sapiens} Probab=92.93 E-value=0.0031 Score=67.35 Aligned_cols=154 Identities=10% Similarity=0.023 Sum_probs=91.5 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... . .... ....+++.+...+.+.++.++..++.++..++.... T Consensus 480 ~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~~ 553 (852) T 6EN4_C 480 ICGTVLWRLN-NKSAKVRQQAADLISRTAVVMKT---C-QEEK-LMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIG 553 (852) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhChh---h-cCHH-HHHhHHHHHHHHccCCCHHHHHHHHHHHHHHHHhhC Confidence 4556666666 46677888899999888764221 0 0001 123566777777777778888889999988876521 Q NP_000290.2 628 L--HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~--~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) . .......+++.+...+.+ .++.++..++.++..++...+...........+..++..+.+. +..++..++ T Consensus 554 ~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~vr~~a~ 626 (852) T 6EN4_C 554 MHKMTPPIKDLLPRLTPILKN------RHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAH-KKAIRRATV 626 (852) T ss_pred chhchhhHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhhCHHHCCHHHHHhcHHHHHHHhcCC-CHHHHHHHH Confidence 1 111112355666666655 3567888888888888764322111000012344455555444 566777777 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .++..+... T Consensus 627 ~~l~~l~~~ 635 (852) T 6EN4_C 627 NTFGYIAKA 635 (852) T ss_pred HHHHHHHHH Confidence 777777643 No 258 >6SA6_A DARPin-Armadillo fusion A5; protein fusion, DARPin, Armadillo, shared; HET: EDO; 1.6A {synthetic construct} Probab=92.89 E-value=0.0032 Score=61.05 Aligned_cols=112 Identities=26% Similarity=0.312 Sum_probs=76.5 Template_Neff=12.400 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+...++.++..++.+|.+++.........+...++++.+..++...+..++..++.++..++.........+ T Consensus 284 ~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~~ 363 (397) T 6SA6_A 284 ALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQKQAV 363 (397) T ss_dssp HHHHHHHHTTCSSHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHHTSCHHHHHHH T ss_pred hHHHHHHHhcCCcHHHHHHHHHHHHHHhcCcHHHHHHHHhcChHHHHHHHhcCCCHHHHHHHHHHHHHHhcCCHHHHHHH Confidence 45556666666667788888888888876544333334445677788888877777888899999998886434333334 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++++.+..++. ..++.++..++.++..++ T Consensus 364 ~~~~~~~~l~~~l~-~~~~~v~~~a~~~l~~l~ 395 (397) T 6SA6_A 364 KEAGALEKLEQLQS-HENEKIQKEAQEALEKLQ 395 (397) T ss_dssp HHTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHH T ss_pred HHcCchHHHHHHHh-cccHHHHHHHHHHHHHHh Confidence 44456777777776 456677777887777665 No 259 >6FT5_A A3_A3; alphaRep, artificial protein, chimera, bidomain; HET: GOL, SO4; 1.94A {synthetic construct} Probab=92.89 E-value=0.0032 Score=60.70 Aligned_cols=91 Identities=14% Similarity=0.155 Sum_probs=53.6 Template_Neff=12.800 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) ..++.+...+.+.+..++..++..+..+.. ...++.+...+.+.++.++..++..+..+.. T Consensus 23 ~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~-----------~~~~~~l~~~l~~~~~~vr~~a~~~L~~~~~-------- 83 (409) T 6FT5_A 23 EKVEMYIKNLQDDSYYVRRAAAYALGKIGD-----------ERAVEPLIKALKDEDAWVRRAAADALGQIGD-------- 83 (409) T ss_pred hHHHHHHHHhcCCCHHHHHHHHHHHHHhcC-----------cchHHHHHHHhcCCCHHHHHHHHHHHHHHcC-------- Confidence 445556666666667777777777766643 1234445555556666777777777766543 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ...++.+...+. +.++.++..++.++..+. T Consensus 84 ---~~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~ 113 (409) T 6FT5_A 84 ---ERAVEPLIKALK-DEDGWVRQSAAVALGQIG 113 (409) T ss_pred ---chhHHHHHHHhc-CCCHHHHHHHHHHHHhhC Confidence 123344455554 445566666666666554 No 260 >3C5W_A PP2A A subunit, PP2A C; methylesterase, phosphatase, PP2A, HYDROLASE; 2.8A {Homo sapiens} Probab=92.86 E-value=0.0032 Score=54.65 Aligned_cols=146 Identities=11% Similarity=0.041 Sum_probs=96.0 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... .. ....+++.+...+.+.++.++..++.++..+..... T Consensus 86 ~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-------~~-~~~~~~~~l~~~~~~~~~~~r~~a~~~l~~l~~~~~ 156 (232) T 3C5W_A 86 LNSLCMAWLV-DHVYAIREAATSNLKKLVEKFGK-------EW-AHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCG 156 (232) T ss_dssp HHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHHCH-------HH-CCCCCHHHHHHGGGCSSHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHh-CCCHHHHHHHHHHHHHHHHHhCh-------hH-HHhcHHHHHHHHhCCCCHHHHHHHHHHHHHHHHHhC Confidence 4566666776 46677888899998888764221 11 123566777777777778888899999988876521 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) .. .....+++.+...+.+ .++.++..++.++..+....+. ......+++.+..++.+. ++.++..++.+ T Consensus 157 ~~-~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~---~~~~~~~~~~l~~~~~~~-~~~vr~~a~~~ 225 (232) T 3C5W_A 157 QD-ITTKHMLPTVLRMAGD------PVANVRFNVAKSLQKIGPILDN---STLQSEVKPILEKLTQDQ-DVDVKYFAQEA 225 (232) T ss_dssp HH-HHHHHTHHHHHHGGGC------SSHHHHHHHHHHHHHHGGGSCH---HHCCCCCHHHHHHHHTCS-SHHHHHHHHHH T ss_pred hh-ccHhcHHHHHHHHhCC------CcHHHHHHHHHHHHHHHHHcCc---hHHHHHHHHHHHHHHhcC-CHHHHHHHHHH Confidence 11 1122355666666665 3678888999999988764221 112234566777777765 77889989888 Q NP_000290.2 708 LSDMWS 713 (747) Q Consensus 708 LsnL~~ 713 (747) |..++. T Consensus 226 l~~l~~ 231 (232) T 3C5W_A 226 LTVLSL 231 (232) T ss_dssp HHHTTC T ss_pred HHHHhc Confidence 887753 No 261 >4LAC_A Serine/threonine-protein phosphatase 2A activator (E.C.5.2.1.8); PP2A, PTPA, protein phosphatase, signaling; HET: AGS, MES; 2.82A {Homo sapiens} Probab=92.86 E-value=0.0033 Score=56.30 Aligned_cols=110 Identities=11% Similarity=0.093 Sum_probs=66.6 Template_Neff=12.800 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..+.++.|+..+. +.++.++..++.+|..+...... . . ....+++.+...+.+.++.++..++.+|..+.. T Consensus 31 ~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~------~-~-~~~~~~~~l~~~l~~~~~~vr~~~~~~l~~~~~ 101 (258) T 4LAC_A 31 SLYPIAVLIDELR-NEDVQLRLNSIKKLSTIALALGV------E-R-TRSELLPFIVELAEDAKWRVRLAIIEYMPLLAG 101 (258) T ss_pred cccHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHccCH------H-H-HHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHH Confidence 3456777788887 46778888888888888754221 1 1 123456667777777777888888888887765 Q NP_000290.2 625 HPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 625 ~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) .... ......+++.+..++.+ .++.++..++.+|..++. T Consensus 102 ~~~~-~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~ 140 (258) T 4LAC_A 102 QLGV-EYFDEKLNSLCMAWLVD------HVYAIREAATSNLKKLVE 140 (258) T ss_pred hCCC-hHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHH Confidence 4111 00112234444455444 245666666666666654 No 262 >4FDD_A Transportin-1, RNA-binding protein FUS; HEAT repeats, Karyopherin, nuclear import; 2.3A {Homo sapiens} Probab=92.57 E-value=0.0039 Score=65.83 Aligned_cols=150 Identities=10% Similarity=0.046 Sum_probs=86.4 Template_Neff=13.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) .++.+...+. +.++.++..++.++..++..... .... ....+++.+...+.+.++.++..++.++..++.. . T Consensus 360 ~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~v~~~~~~~l~~~~~~~~ 432 (852) T 4FDD_A 360 ILPLLKELLF-HHEWVVKESGILVLGAIAEGCMQ-----GMIP-YLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVV 432 (852) T ss_dssp HHHHHHHHHT-CSSHHHHHHHHHHHHHTTTTTHH-----HHGG-GHHHHHHHHHHHTTCSSHHHHHHHHHHHHHTHHHHH T ss_pred HHHHHHHHHh-CCChHHHHHHHHHHHHHHHHHHH-----hhHH-hHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHhc Confidence 3444555555 35667777888888888764321 1111 1234666777777777788889999999888764 1 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. .......+++.+...+.+ .++.++..++.++..++........... ..++..+...+.+. +..++..++ T Consensus 433 ~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~-~~~~~~~~~ 504 (852) T 4FDD_A 433 SQPPDTYLKPLMTELLKRILD------SNKRVQEAACSAFATLEEEACTELVPYL-AYILDTLVFAFSKY-QHKNLLILY 504 (852) T ss_dssp HSCTTTTHHHHHHHHHHHHTC------SSHHHHHHHHHHHHHHHHHHGGGGGGGH-HHHHHHHHHHHHHC-CHHHHHHHH T ss_pred CCCCCcchHHHHHHHHHHHHc------CCHHHHHHHHHHHHHHHHHHHHhhHHHH-HHHHHHHHHHhhcc-CHHHHHHHH Confidence 11 011112344555555554 2567888888888888764322111111 23455555555544 445566666 Q NP_000290.2 706 LLLSDMW 712 (747) Q Consensus 706 ~aLsnL~ 712 (747) .+|..++ T Consensus 505 ~~l~~l~ 511 (852) T 4FDD_A 505 DAIGTLA 511 (852) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 6666665 No 263 >5NR4_A CLIP-associating protein 2; Microtubules, TOG domain, Tubulin, Structural; 1.198A {Homo sapiens} Probab=92.57 E-value=0.004 Score=54.44 Aligned_cols=148 Identities=8% Similarity=0.066 Sum_probs=97.5 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... .... ....+++.+...+.+.+..++..++.++..++.... T Consensus 53 ~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 125 (230) T 5NR4_A 53 TVDALTGWVG-SSNYRVSLMGLEILSAFVDRLST-----RFKS-YVAMVIVALIDRMGDAKDKVRDEAQTLILKLMDQVA 125 (230) T ss_dssp HHHHHHHHHH-CSSHHHHHHHHHHHHHHHHHHGG-----GGGG-GHHHHHHHHHHHTTCSSHHHHHHHHHHHHHHHHHTS T ss_pred HHHHHHHHHc-CCCHHHHHHHHHHHHHHHHHhhH-----HHHH-HHHHHHHHHHHHhccCCHHHHHHHHHHHHHHHHcCC Confidence 5566667776 46778888999999988764321 1111 123567777777777777888889999888875421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . ...+++.+...+.+ .++.++..++.++..++........ ....+++.+...+.+. ++.++..++.+ T Consensus 126 ~----~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~~~--~~~~~~~~l~~~l~~~-~~~vr~~a~~~ 192 (230) T 5NR4_A 126 P----PMYIWEQLASGFKH------KNFRSREGVCLCLIETLNIFGAQPL--VISKLIPHLCILFGDS-NSQVRDAAILA 192 (230) T ss_dssp C----HHHHHHHHGGGGGC------SCHHHHHHHHHHHHHHHHHHCSTTS--CHHHHHHHHHHHTTCS-SHHHHHHHHHH T ss_pred C----HHHHHHHHHhcCCC------CCHHHHHHHHHHHHHHHHHhCCCcc--cHHHHHHHHHHHHCCC-CHHHHHHHHHH Confidence 1 11244555555554 3677888889998888764322211 1124567777777766 78899999999 Q NP_000290.2 708 LSDMWSSK 715 (747) Q Consensus 708 LsnL~~~~ 715 (747) +..+.... T Consensus 193 l~~l~~~~ 200 (230) T 5NR4_A 193 IVEIYRHV 200 (230) T ss_dssp HHHHHHHH T ss_pred HHHHHHHH Confidence 98887543 No 264 >3C5W_A PP2A A subunit, PP2A C; methylesterase, phosphatase, PP2A, HYDROLASE; 2.8A {Homo sapiens} Probab=92.51 E-value=0.0041 Score=53.94 Aligned_cols=107 Identities=12% Similarity=0.133 Sum_probs=62.9 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+. +.++.++..++..|..+...... . . ....+++.+...+.+.++.++..++.++..++.... T Consensus 8 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~------~-~-~~~~~~~~l~~~l~~~~~~vr~~~~~~l~~l~~~~~ 78 (232) T 3C5W_A 8 PIAVLIDELR-NEDVQLRLNSIKKLSTIALALGV------E-R-LSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLG 78 (232) T ss_dssp HHHHHHHHHT-CSSHHHHHHHHTTHHHHHHHHCS------S-H-CCCCCHHHHHHHTTCSSHHHHHHHHTTHHHHHHHHC T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHhCh------H-H-HHHhHHHHHHHHHhCCCHHHHHHHHHHHHHHHHhhC Confidence 4566777776 46677888888888887754221 1 1 123556667777777777788888888887765411 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) .. .....+++.+...+.+ .++.++..++.++..++. T Consensus 79 ~~-~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~ 114 (232) T 3C5W_A 79 VE-FFDEKLNSLCMAWLVD------HVYAIREAATSNLKKLVE 114 (232) T ss_dssp GG-GTTTTHHHHHHHHTTC------SSHHHHHHHHHHHHHHHH T ss_pred HH-HHHHHHHHHHHHHHhC------CCHHHHHHHHHHHHHHHH Confidence 10 1111234444444444 245566666666666554 No 265 >6XU2_A Importin-5, antipain; human karyopherin, PA-PB1 sub-complex nuclear; HET: FC0, OAR; 2.834A {Homo sapiens} Probab=92.50 E-value=0.0042 Score=68.79 Aligned_cols=152 Identities=9% Similarity=0.112 Sum_probs=85.0 Template_Neff=12.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) .++.+...+. +.++.++..++.++..++..... .... .-..+++.+...+.+.++.++..++.++..++.. . T Consensus 377 l~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 449 (1115) T 6XU2_A 377 IKEHIMQMLQ-NPDWKYRHAGLMALSAIGEGCHQ-----QMEG-ILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFA 449 (1115) T ss_dssp HHHHHHHHHS-SSCSHHHHHHHHHHHHHHHHHHH-----HHTT-THHHHHHHHGGGGGCSSHHHHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhhHH-----HHHH-HHHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHhcc Confidence 3444555555 35677788888888887764221 0111 1134566677777777888999999999988865 1 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSMLNNIINL--------CRSSA 696 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~giL~~Ll~L--------L~s~~ 696 (747) .. .......+++.+...+.+. .+..++..++.+|..++...+. .....+ ..++..+... +.+. T Consensus 450 ~~~~~~~~~~~~~~l~~~l~~~-----~~~~vr~~a~~~l~~l~~~~~~~~~~~~~-~~~~~~l~~~l~~~~~~~~~~~- 522 (1115) T 6XU2_A 450 PGFQKKFHEKVIAALLQTMEDQ-----GNQRVQAHAAAALINFTEDCPKSLLIPYL-DNLVKHLHSIMVLKLQELIQKG- 522 (1115) T ss_dssp THHHHHHHHHHHHHHHHHHHTT-----CCHHHHHHHHHHHHHHHHTSCHHHHGGGH-HHHHHHHHHHHHHHHHHHHHTC- T ss_pred HHHHHHHHHHHHHHHHHHhccc-----CCHHHHHHHHHHHHHHhccCCHHhHHHHH-HHHHHHHHHHHHHHHHHHHHcC- Confidence 11 1111223555566555431 2567788888888888764322 111111 1223333322 2222 Q NP_000290.2 697 SPKAAEAARLLLSDMWS 713 (747) Q Consensus 697 d~eVr~aAL~aLsnL~~ 713 (747) +..++..++.++..++. T Consensus 523 ~~~~~~~~~~~l~~l~~ 539 (1115) T 6XU2_A 523 TKLVLEQVVTSIASVAD 539 (1115) T ss_dssp CCHHHHHHHHHHHHHHH T ss_pred CHhHHHHHHHHHHHHHH Confidence 45566667777766654 No 266 >4LAC_A Serine/threonine-protein phosphatase 2A activator (E.C.5.2.1.8); PP2A, PTPA, protein phosphatase, signaling; HET: AGS, MES; 2.82A {Homo sapiens} Probab=92.46 E-value=0.0043 Score=55.46 Aligned_cols=146 Identities=11% Similarity=0.041 Sum_probs=96.3 Template_Neff=12.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+..++. +.++.++..++.+|..++..... .. ....+++.+...+.+.+..++..++.++..+..... T Consensus 112 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~-------~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 182 (258) T 4LAC_A 112 LNSLCMAWLV-DHVYAIREAATSNLKKLVEKFGK-------EW-AHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCG 182 (258) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHcCCh-------hH-HHHhHHHHHHHHcCCCCHHHHHHHHHHHHHHHHcCC Confidence 4566666776 46678888899999888764221 11 234567777777777778889999999888876521 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) .. .....+++.+...+.+ .++.++..++.+|..+...... ......+++.+..++.+. ++.++..++.+ T Consensus 183 ~~-~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~---~~~~~~~~~~l~~~l~~~-~~~vr~~a~~~ 251 (258) T 4LAC_A 183 QD-ITTKHMLPTVLRMAGD------PVANVRFNVAKSLQKIGPILDN---STLQSEVKPILEKLTQDQ-DVDVKYFAQEA 251 (258) T ss_pred CC-ccHhhHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhCc---chhHHHHHHHHHHHHCCC-CHHHHHHHHHH Confidence 11 1122355666666665 3678888999999888754221 112234566677777765 77888899888 Q NP_000290.2 708 LSDMWS 713 (747) Q Consensus 708 LsnL~~ 713 (747) |..+.. T Consensus 252 l~~l~~ 257 (258) T 4LAC_A 252 LTVLSL 257 (258) T ss_pred HHHHHh Confidence 887753 No 267 >6EN4_C Splicing factor 3B subunit 3; Protein complex, splicing modulator, SPLICING; HET: BGZ; 3.08A {Homo sapiens} Probab=92.45 E-value=0.0043 Score=66.18 Aligned_cols=147 Identities=10% Similarity=0.006 Sum_probs=89.0 Template_Neff=12.900 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.++..+. +.+..++..++.++..+....+. ....+ -..+++.+...+.+.+..++..++.++..+.... T Consensus 675 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~ 747 (852) T 6EN4_C 675 TVLPALMNEYR-VPELNVQNGVLKSLSFLFEYIGE-----MGKDY-IYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGV 747 (852) T ss_pred hHHHHHHHHhC-CCCHHHHHHHHHHHHHHHhhCch-----hhHHH-HHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHcC Confidence 35666777776 46677888899999888764321 01111 1356667777777777778888877777776541 Q NP_000290.2 627 -LLH-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 627 -e~~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) ... ......+++.+...+.+ .++.++..++.++..+...... ...++.+...+.+. ++.++..+ T Consensus 748 ~~~~~~~~~~~~~~~l~~~~~~------~~~~~r~~~~~~l~~l~~~~~~-------~~~~~~l~~~l~~~-~~~vr~~a 813 (852) T 6EN4_C 748 YGFGCEDSLNHLLNYVWPNVFE------TSPHVIQAVMGALEGLRVAIGP-------CRMLQYCLQGLFHP-ARKVRDVY 813 (852) T ss_pred ccCCcHHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhhCc-------cchHHHHHHHhCCC-cHHHHHHH Confidence 110 00111233333333333 2567777888888777643211 23455566666655 77889999 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.++..+... T Consensus 814 ~~~l~~l~~~ 823 (852) T 6EN4_C 814 WKIYNSIYIG 823 (852) T ss_pred HHHHHHHHhh Confidence 9998888754 No 268 >1QBK_B STRUCTURE OF THE KARYOPHERIN BETA2-RAN; HEAT REPEATS, NUCLEAR TRANSPORT PROTEIN; HET: GNP; 3.0A {Homo sapiens} SCOP: a.118.1.1 Probab=92.44 E-value=0.0043 Score=66.06 Aligned_cols=151 Identities=10% Similarity=0.047 Sum_probs=89.7 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) .++.+...+. +.++.++..++.++..++..... .... ....+++.+...+.+.++.++..++.++..++... T Consensus 398 ~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 470 (890) T 1QBK_B 398 ILPLLKELLF-HHEWVVKESGILVLGAIAEGCMQ-----GMIP-YLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVV 470 (890) T ss_pred HHHHHHHHHc-CCCHHHHHHHHHHHHHHHHHhHh-----hhHh-hHHHHHHHHHHHhcCCChHHHHHHHHHHHHHHHHHc Confidence 3445555555 35677888888888888764321 1111 12346677777777778889999999999887651 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. .......+++.+...+.+ .++.++..++.++..++........... ..+++.+...+.+. +..++..++ T Consensus 471 ~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~-~~~~~~~~~ 542 (890) T 1QBK_B 471 SQPPDTYLKPLMTELLKRILD------SNKRVQEAACSAFATLEEEACTELVPYL-AYILDTLVFAFSKY-QHKNLLILY 542 (890) T ss_pred CCCCchhhHHHHHHHHHHHHC------CCHHHHHHHHHHHHHHHHHHHHhhHHHH-HHHHHHHHHHhhcc-CHHHHHHHH Confidence 11 111112345555555554 3567888889998888764322111111 23455555555544 455666666 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .++..++. T Consensus 543 ~~l~~l~~ 550 (890) T 1QBK_B 543 DAIGTLAD 550 (890) T ss_pred HHHHHHHH Confidence 77666654 No 269 >6CRI_I Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=92.43 E-value=0.0043 Score=62.06 Aligned_cols=145 Identities=10% Similarity=0.022 Sum_probs=87.2 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+....++.++..++.+|..+..... . ....++.+...+.+.++.++..++.+|..+..... T Consensus 415 ~~~~l~~~l~~~~~~~~r~~a~~~l~~~~~~~~-------~----~~~~l~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 483 (570) T 6CRI_I 415 VIATLCENLDSLDEPEARAAMIWIVGEYAERID-------N----ADELLESFLEGFHDKSTQVQLQLLTAIVKLFLKKP 483 (570) T ss_dssp THHHHTSSCTTCCCHHHHHHHHHHHHHTTTTST-------T----HHHHHHHHTTSGGGSCSHHHHHHHHHHHHHHHHCT T ss_pred HHHHHHHchhhCCCHHHHHHHHHHHHHHHHhcc-------C----HHHHHHHHHHccCCCCHHHHHHHHHHHHHHHhcCc Confidence 456666666522456777788888887765311 0 13456667777777778889999999988876521 Q NP_000290.2 628 LHRVMGNQVFPEVTRL-LTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 628 ~~~ll~~giI~~Ll~L-L~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) . . +.. .+..++.. +.+. .+..++..+..++..+.... ......+ ...++.++..+.+. ++.++..++. T Consensus 484 ~-~-~~~-~~~~~l~~~~~~~-----~~~~vr~~a~~~~~~l~~~~-~~~~~~~-~~~~~~l~~~l~~~-~~~~~~~~~~ 552 (570) T 6CRI_I 484 T-E-TQE-LVQQVLSLATQDS-----DNPDLRDRGYIYWRLLSTDP-VAAKEVV-LAEKPLISEETDLI-EPTLLDELIC 552 (570) T ss_dssp T-T-THH-HHHHHHCCCCCSC-----CCHHHHHHHHHHHHHHHHCH-HHHHHHT-SCCCCCCCCCCCCC-CHHHHHHHHS T ss_pred H-H-HHH-HHHHHHHHHhcCC-----CCchHHHHHHHHHHHhcCCh-HHHHHHH-HccCCCCCccccCC-chhHHHHHHH Confidence 1 0 111 12222222 3321 15678888888888776542 2111222 23466666666655 6788888888 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) +|..++.. T Consensus 553 ~l~~l~~~ 560 (570) T 6CRI_I 553 YIGTLASV 560 (570) T ss_dssp CSSBHHHH T ss_pred HhhcHHHH Confidence 88887754 No 270 >2RU4_B Armadillo Repeat Protein, N-terminal fragment; solenoid repeat, Armadillo repeat motif; NMR {synthetic construct} Probab=92.41 E-value=0.0045 Score=45.28 Aligned_cols=71 Identities=30% Similarity=0.361 Sum_probs=42.5 Template_Neff=12.400 Q NP_000290.2 287 GGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 287 ~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) ++++.+...+...+..++..+++++.+++.........+...+.+..+...+. ..++.++..++.++.+++ T Consensus 12 ~~~~~l~~~l~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~ 82 (84) T 2RU4_B 12 GALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAVKEAGALEKLEQLQS-HENEKIQKEAQEALEKLQ 82 (84) T ss_dssp TSHHHHHHHTTCSCHHHHHHHHHHHHHHHTCSSSTTHHHHHHTCHHHHHHHTT-SSCHHHHHHHHHHHHHHC T ss_pred CcHHHHHHHhcCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHhc-CCCHHHHHHHHHHHHHHh Confidence 45555666666556677788888888877653332223333445555665554 345566666777766654 No 271 >4L7M_A Putative uncharacterized protein; HEAT-repeats, Hypothetical, UNKNOWN FUNCTION; HET: MSE, GOL; 2.002A {Thermococcus onnurineus} Probab=92.32 E-value=0.0047 Score=55.57 Aligned_cols=75 Identities=17% Similarity=0.187 Sum_probs=52.1 Template_Neff=12.800 Q NP_000290.2 545 HSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 545 e~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) +.+.++.+...+. +.++.++..++.+|..+...... . .... .....++.|...+.+.++.++..++.+|..+.. T Consensus 35 ~~~~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~ 108 (269) T 4L7M_A 35 DKRALFLILELAG-EDDETTRLRAFVALGEILKRADS---D-LRMM-VLERHLDVFINALSQENEKVTIKALRALGYLVK 108 (269) T ss_dssp CHHHHHHHHHHTT-SSCHHHHHHHHHHHHHHHTTSCH---H-HHHH-HHHHHHHHHHHTCCSSSHHHHHHHHHHHHHHHT T ss_pred CcchHHHHHHHhC-CCCHHHHHHHHHHHHHHHhcCCH---H-HHHH-HHHhHHHHHHHHhcCCCHHHHHHHHHHHHHHHh Confidence 4467778888887 46778888999999888764211 0 0111 123567777888887788888889998888876 Q NP_000290.2 625 H 625 (747) Q Consensus 625 ~ 625 (747) . T Consensus 109 ~ 109 (269) T 4L7M_A 109 D 109 (269) T ss_dssp T T ss_pred c Confidence 3 No 272 >5WBJ_A Regulatory-associated protein of TOR 1,Eukaryotic; Raptor, TOS, PROTEIN BINDING; 3.0A {Arabidopsis thaliana} Probab=92.23 E-value=0.0059 Score=72.68 Aligned_cols=100 Identities=11% Similarity=0.096 Sum_probs=68.1 Template_Neff=8.700 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLH----------- 629 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~----------- 629 (747) ++.++..++.+|..|+...+. ........++++.|+.+|.+.+++++..++.+|++++...... T Consensus 612 ~~~lr~~a~~~L~~L~~~~~~-----~~~~~~~~~~~~~L~~lL~~~~~~VRaaal~aL~~li~~~~~~~~~~~~~~~~~ 686 (1287) T 5WBJ_A 612 EPLFLQWLCLCLGKLWEDFME-----AQIMGREANAFEKLAPLLSEPQPEVRAAAVFALGTLLDIGFDSNKSVVEDEFDD 686 (1287) T ss_dssp CHHHHHHHHHHHHHHHTTCHH-----HHHHHHHTTHHHHHGGGGGCSCHHHHHHHHHHHHHTCC------------CCCC T ss_pred CHHHHHHHHHHHHHHHhccHH-----HHHHHHHcCHHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCccccccccCCCCCH Confidence 456667788888888765432 1233345678889999999889999999999999998762110 Q NP_000290.2 630 ---RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 630 ---~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~ 671 (747) ..+..+++..|..++.+ .++.++..++.+|++++.. T Consensus 687 ~~~~~~~~~i~~~l~~~~~D------~S~~VR~e~~~aLs~~~~~ 725 (1287) T 5WBJ_A 687 DEKIRAEDAIIKSLLDVVSD------GSPLVRAEVAVALARFAFG 725 (1287) T ss_dssp CHHHHHHHHHHHHHHTTTTC------SCHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHccC------CCHHHHHHHHHHHHHHHHh Confidence 00233455566666655 3678889999999888754 No 273 >5WBK_A Regulatory-associated protein of TOR 1,Ribosomal; Raptor, TOS, PROTEIN BINDING; 3.11A {Arabidopsis thaliana} Probab=92.22 E-value=0.0059 Score=72.65 Aligned_cols=101 Identities=11% Similarity=0.093 Sum_probs=68.3 Template_Neff=8.700 Q NP_000290.2 560 KKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLH---------- 629 (747) Q Consensus 560 ~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~---------- 629 (747) .++.++..++.+|..|+...+. ........++++.|+.+|.+.+++++..++.+|+.++...... T Consensus 611 ~~~~lr~~a~~~L~~L~~~~~~-----~~~~~~~~~~~~~L~~lL~~~~~~VRaaal~AL~~li~~~~~~~~~~~~~~~~ 685 (1287) T 5WBK_A 611 PEPLFLQWLCLCLGKLWEDFME-----AQIMGREANAFEKLAPLLSEPQPEVRAAAVFALGTLLDIGFDSNKSVVEDEFD 685 (1287) T ss_dssp -CHHHHHHHHHHHHHHHTTCHH-----HHHHHHTTTHHHHHGGGGGCSCHHHHHHHHHHHHHHCC------------CCC T ss_pred CCHHHHHHHHHHHHHHHcccHH-----HHHHHHHCCHHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCccccccccCCCCC Confidence 3456677788888888765432 1233345678889999999888999999999999998762110 Q NP_000290.2 630 ----RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 630 ----~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~ 671 (747) ..+..+++..|..++.+ .++.++..++.+|++++.. T Consensus 686 ~~~~~~~~~~i~~~l~~~~~D------~s~~VR~e~~~als~~~~~ 725 (1287) T 5WBK_A 686 DDEKIRAEDAIIKSLLDVVSD------GSPLVRAEVAVALARFAFG 725 (1287) T ss_dssp CCHHHHHHHHHHHHHHTTTTC------SCHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHccC------CCHHHHHHHHHHHHHHHHh Confidence 01233455566666655 3678888899999888754 No 274 >2QK2_A LP04448p; Mini spindles, Msps, XMAP215, Dis1; 2.1A {Drosophila melanogaster} Probab=92.22 E-value=0.005 Score=54.55 Aligned_cols=145 Identities=9% Similarity=0.135 Sum_probs=94.6 Template_Neff=12.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL-QSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL-~s~d~eVr~~AL~aLsnLa~~- 625 (747) .++.+...+. +.++.++..++..|..+....+. .... .-..+++.+...+ .+.++.++..++.+|..+... T Consensus 16 l~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~~~~ 88 (242) T 2QK2_A 16 MPKDFYDKLE-EKKWTLRKESLEVLEKLLTDHPK-----LENG-EYGALVSALKKVITKDSNVVLVAMAGKCLALLAKGL 88 (242) T ss_dssp SCTTHHHHHT-CSSHHHHHHHHHHHHHHHHHCSS-----BCCC-CCHHHHHHHHHHHHHCSCHHHHHHHHHHHHHHHHHH T ss_pred CCHHHHHHHh-ccchHHHHHHHHHHHHHHhhCcc-----cccc-hHHHHHHHHHHHHccCcHHHHHHHHHHHHHHHHHHh Confidence 4566777777 47788888999999988764321 1111 1134667777777 777788999999999988865 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) ... .... ..+++.+...+.+ .+..++..++.+|..+....+ ....++.+...+.+. ++.++..+ T Consensus 89 ~~~~~~~~-~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~~~-------~~~~~~~l~~~l~~~-~~~~r~~~ 153 (242) T 2QK2_A 89 AKRFSNYA-SACVPSLLEKFKE------KKPNVVTALREAIDAIYASTS-------LEAQQESIVESLSNK-NPSVKSET 153 (242) T ss_dssp GGGGHHHH-HHHHHHHHHGGGC------CCHHHHHHHHHHHHHHHTTSC-------HHHHHHHHHHHTTCS-CHHHHHHH T ss_pred hHhHHHHH-HhHHHHHHHHHhc------CCHHHHHHHHHHHHHHHHcCC-------HHHHHHHHHHHHcCC-CHHHHHHH Confidence 211 1111 2356666666665 356788888888888875421 112455566666655 67778888 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.++..++.. T Consensus 154 ~~~l~~l~~~ 163 (242) T 2QK2_A 154 ALFIARALTR 163 (242) T ss_dssp HHHHHHHHTT T ss_pred HHHHHHHHHh Confidence 8887777653 No 275 >3W3U_A Importin subunit beta-3; HEAT repeat, nuclear import, PROTEIN; 2.6A {Saccharomyces cerevisiae} Probab=92.21 E-value=0.005 Score=67.54 Aligned_cols=115 Identities=14% Similarity=0.059 Sum_probs=64.9 Template_Neff=13.000 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLR-SPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~-s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .+++.+...+.+.++.++..++.++..+...............+++.+...+. +.+..++..++.++..++........ T Consensus 397 ~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~~~~~~~~~ 476 (1078) T 3W3U_A 397 KILDMVIPLINDPHPRVQYGCCKVLGQISTAFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVAFSEFASKDIL 476 (1078) T ss_dssp HHHHHHGGGGGCSSHHHHHHHHHHHHHHHHHTTTHHHHHHHHHHHHHHHHHSSTTSCHHHHHHHHHHHHHHHTTCCHHHH T ss_pred HHHHHHHHHccCCCHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHcCCCCCHHHHHHHHHHHHHHHHhCChhhh Confidence 34444455555566778888888888876543221111111234555555555 34566777788888777654322111 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ......++..+...+. ..++.++..++.++..++.. T Consensus 477 ~~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 512 (1078) T 3W3U_A 477 EPYLDSLLTNLLVLLQ-SNKLYVQEQALTTIAFIAEA 512 (1078) T ss_dssp GGGHHHHHHHHHHHHT-CSSHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHH Confidence 1111245555666665 44567778888888877754 No 276 >2IW3_B ELONGATION FACTOR 3A; ACETYLATION, ATP-BINDING, ELONGATION FACTOR, PROTEIN; HET: MSE, ADP, SO4; 2.4A {SACCHAROMYCES CEREVISIAE} Probab=92.03 E-value=0.0058 Score=68.10 Aligned_cols=148 Identities=16% Similarity=0.128 Sum_probs=74.2 Template_Neff=11.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.|..++. +.+..++..|+.+|..++..... .. ....++.++..+.+.+. ...++..+..+..... T Consensus 176 i~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~-------~~--~~~~~~~l~~~l~~~~~--~~~~~~~l~~~~~~~~ 243 (986) T 2IW3_B 176 LIPVLSETMW-DTKKEVKAAATAAMTKATETVDN-------KD--IERFIPSLIQCIADPTE--VPETVHLLGATTFVAE 243 (986) T ss_dssp HHHHHHHHTT-CSCHHHHHHHHHHHHHHGGGCCS-------ST--TGGGHHHHHHHHHCGGG--HHHHHHHHTTCCCCSC T ss_pred HHHHHHHhcC-cCCHHHHHHHHHHHHHHHHhcCc-------HH--HHHHHHHHHHHhcCccc--chHHHHHHHHchhhcc Confidence 5566667776 45667777888888777653211 11 12344455555543322 2222323222222110 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK-QYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~-~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) ........+++.+...+.+ .++.++..++.++..++........ ......+++.|+.++.+..++.++..++. T Consensus 244 ~~~~~~~~~l~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~i~~~l~~~l~d~~d~~vr~~a~~ 317 (986) T 2IW3_B 244 VTPATLSIMVPLLSRGLNE------RETGIKRKSAVIIDNMCKLVEDPQVIAPFLGKLLPGLKSNFATIADPEAREVTLR 317 (986) T ss_dssp CCHHHHHHHHHHHHHHHTS------SSHHHHHHHHHHHHHHHTTCCCHHHHHHHHTTTHHHHHHHHHHCCCHHHHHHHHH T ss_pred cCHHHHHhHHHHHHHhccc------ccccccHHHHHHHHHHHHHhcCHhHHHHHHHHHHHHHHHhhcCCCCHHHHHHHHH Confidence 0000011245555555554 3567778888888877754211100 00112356666666665423677777777 Q NP_000290.2 707 LLSDMWS 713 (747) Q Consensus 707 aLsnL~~ 713 (747) +|..+.. T Consensus 318 ~l~~l~~ 324 (986) T 2IW3_B 318 ALKTLRR 324 (986) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 7777643 No 277 >4G3A_B CLIP-associating protein; TOG domain, HEAT repeat, MAP; HET: GOL; 1.994A {Drosophila melanogaster} Probab=91.94 E-value=0.0059 Score=54.01 Aligned_cols=150 Identities=10% Similarity=0.094 Sum_probs=93.1 Template_Neff=12.600 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.++..+. +.++.++..++..|..++..... . .... ....+++.+...+.+.++.++..++.++..++... T Consensus 7 ~~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~---~-~~~~-~~~~~~~~l~~~l~d~~~~v~~~a~~~l~~l~~~~ 80 (237) T 4G3A_B 7 SDLDGFIQQMP-KADMRVKVQLAEDLVTFLSDDTN---S-IVCT-DMGFLIDGLMPWLTGSHFKIAQKSLEAFSELIKRL 80 (237) T ss_dssp SSHHHHHHHST-TCCHHHHHHHHHHHHHHHHCTTS---C-CCCS-CHHHHHHHHGGGGSSSCHHHHHHHHHHHHHHHHHH T ss_pred chHHHHHHhcC-cCCHHHHHHHHHHHHHHhhCCCC---C-cccc-cHHHHHHHHHHHhcCCcHHHHHHHHHHHHHHHHHh Confidence 35666777777 46778888999999888764221 0 0111 12345677777777778889999999999988652 Q NP_000290.2 627 L-LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNII-NLCRSSASPKAAEAA 704 (747) Q Consensus 627 e-~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll-~LL~s~~d~eVr~aA 704 (747) . ........+++.++..+.+ .+..++..++.+|..+........ ...++.+. .++.+. ++.++..+ T Consensus 81 ~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~~~~~~-----~~~~~~l~~~~l~~~-~~~~r~~a 148 (237) T 4G3A_B 81 GSDFNAYTATVLPHVIDRLGD------SRDTVREKAQLLLRDLMEHRVLPP-----QALIDKLATSCFKHK-NAKVREEF 148 (237) T ss_dssp GGGGGGTHHHHHHHHHHHHTC------SCHHHHHHHHHHHHHHHHTTSSCH-----HHHHHHHHHHHTTCS-CHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHcCCCCH-----HHHHHHHHHHHhhCC-CHHHHHHH Confidence 1 1111112356666666655 356788888888888875311111 12345555 555544 56677777 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.++..++.. T Consensus 149 ~~~l~~l~~~ 158 (237) T 4G3A_B 149 LQTIVNALHE 158 (237) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 7777776644 No 278 >5EWP_B Uncharacterized protein; translocation and attachment of rhoptries; 1.8A {Plasmodium falciparum Santa Lucia} Probab=91.92 E-value=0.0062 Score=55.67 Aligned_cols=176 Identities=16% Similarity=0.152 Sum_probs=134.6 Template_Neff=11.800 Q NP_000290.2 528 CPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDAT----------------LEACAGALQNLTASK--GLMSSGMSQL 589 (747) Q Consensus 528 ~~~~~~~~ni~~~~~lve~G~I~~LL~LL~ss~d~eV----------------r~~AL~aL~nLs~~s--~~~s~~~~~~ 589 (747) +-+++++++++.+..+++.|+++.|+.+|.. .+... +..++++|.+++... +. ... T Consensus 7 ~~~~~~~~~~~~~~~~~~~g~i~~L~~ll~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~-----~~~ 80 (252) T 5EWP_B 7 KLLSFTSNDILRFDKAYDENDVQEFVNLCSS-TCEIEKLEDRMHPWAADPKTIGALSATQLAILASKENEPH-----YKD 80 (252) T ss_dssp --CCCCCHHHHHHHHHHHTTCHHHHHHHTTC-CCBCCCC--CCCSSSCCCCBHHHHHHHHHHHHHTCTTCTH-----HHH T ss_pred HHHhccHHHHhhhHHHHhcCCHHHHHHHhcC-CChHHHHHHHhhhhhCCHHHHHHHHHHHHHHHhcCCCCHH-----HHH Confidence 4456899999999999999999999999983 33222 236888888888652 21 244 Q NP_000290.2 590 IGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRN 667 (747) Q Consensus 590 llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsn 667 (747) .+.+.++++.|+.++...++.++..++++|.+++.. ... ..+...++++.++.++.. .++.++..++++|.+ T Consensus 81 ~~~~~g~i~~l~~~l~~~~~~~~~~a~~~L~~l~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~ 154 (252) T 5EWP_B 81 AIREANGIAVFINLLKSHELDRVHAAVVALSFLSVDNVKNCICMFESGALPYLISGMKS------NIDGMKAACAQTCRN 154 (252) T ss_dssp HHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTTCHHHHHHHHHTTCHHHHHHHTTC------SCHHHHHHHHHHHHH T ss_pred HHHHcccHHHHHHHhhCCCHHHHHHHHHHHHHHhCCCHHHHHHHHHCCcHHHHHHHhhC------CCHHHHHHHHHHHHH Confidence 445778999999999888888999999999999986 443 344556788888888875 367889999999999 Q NP_000290.2 668 LMASQPQLAKQYFSSSMLNNIINLCRSSASP-------KAAEAARLLLSDMWSSKE 716 (747) Q Consensus 668 La~~s~e~~~~Lve~giL~~Ll~LL~s~~d~-------eVr~aAL~aLsnL~~~~~ 716 (747) ++...+.....+.+.++++.|+.++... +. .++..++.+|.+++...+ T Consensus 155 l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~~~~~~a~~~l~~l~~~~~ 209 (252) T 5EWP_B 155 IFVLDKKYKKEFLKLGGITQLVNLLELP-SNYDDSQPLYTQLEAIYHLEDFILNDG 209 (252) T ss_dssp HHTTCHHHHHHHHHTTHHHHHHHTTSCC-TTCCSCSCCHHHHHHHHHHHHHHEETT T ss_pred HHhcCHHHHHHHHHCChHHHHHHHhcCC-CCCCCCchHHHHHHHHHHHHHHHhcCC Confidence 9875455666677778889999988765 33 378889999999987665 No 279 >4QMI_B Cytoskeleton-associated protein 5; PROTEIN BINDING, TOG domain; 1.9A {Homo sapiens} Probab=91.92 E-value=0.006 Score=54.09 Aligned_cols=147 Identities=7% Similarity=-0.004 Sum_probs=97.2 Template_Neff=12.600 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... .... .....++.++..+.+.+..++..++.++..+..... T Consensus 60 ~~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 132 (240) T 4QMI_B 60 LPTALKGRLN-DSNKILVQQTLNILQQLAVAMGP-----NIKQ-HVKNLGIPIITVLGDSKNNVRAAALATVNAWAEQTG 132 (240) T ss_dssp HHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHHGG-----GGGG-GCCCCCHHHHHHTTCSSHHHHHHHHHHHHHHHHHHC T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHhcH-----HHHH-HHHHHHHHHHHHhhcCCHHHHHHHHHHHHHHHHHhC Confidence 4566666676 46778888999999988764321 1111 123466777777777778888889999888875421 Q NP_000290.2 628 LHRVMGNQVF--PEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI--~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) . ..++ +.+...+.+ .++.++..++.+|..++...... ... -..+++.+...+.+. +..++..++ T Consensus 133 ~-----~~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~-~~~-~~~~~~~l~~~l~~~-~~~vr~~a~ 198 (240) T 4QMI_B 133 M-----KEWLEGEDLSEELKK------ENPFLRQELLGWLAEKLPTLRST-PTD-LILCVPHLYSCLEDR-NGDVRKKAQ 198 (240) T ss_dssp S-----HHHHSSSHHHHHHTS------CCHHHHHHHHHHHHHHGGGCSSC-CGG-GGGGHHHHHHHTTCS-SHHHHHHHH T ss_pred h-----hHhccHHHHHHHHhc------CCHHHHHHHHHHHHHHHHhCCCC-cHH-HHHHHHHHHHHHhcC-CHHHHHHHH Confidence 1 1234 555666655 36788888999998877543221 111 124567777777766 788999999 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .++..+.... T Consensus 199 ~~l~~l~~~~ 208 (240) T 4QMI_B 199 DALPFFMMHL 208 (240) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHh Confidence 9998887653 No 280 >4QMJ_A Cytoskeleton-associated protein 5; PROTEIN BINDING, TOG DOMAIN; 2.498A {Homo sapiens} Probab=91.92 E-value=0.006 Score=54.09 Aligned_cols=147 Identities=7% Similarity=-0.004 Sum_probs=97.2 Template_Neff=12.600 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... .... .....++.++..+.+.+..++..++.++..+..... T Consensus 60 ~~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 132 (240) T 4QMJ_A 60 LPTALKGRLN-DSNKILVQQTLNILQQLAVAMGP-----NIKQ-HVKNLGIPIITVLGDSKNNVRAAALATVNAWAEQTG 132 (240) T ss_dssp HHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHHGG-----GGGG-GCCCCCHHHHHGGGCSSHHHHHHHHHHHHHHHHHHC T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHhcH-----HHHH-HHHHHHHHHHHHhhcCCHHHHHHHHHHHHHHHHHhC Confidence 4566666676 46778888999999988764321 1111 123466777777777778888889999888875421 Q NP_000290.2 628 LHRVMGNQVF--PEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI--~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) . ..++ +.+...+.+ .++.++..++.+|..++...... ... -..+++.+...+.+. +..++..++ T Consensus 133 ~-----~~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~-~~~-~~~~~~~l~~~l~~~-~~~vr~~a~ 198 (240) T 4QMJ_A 133 M-----KEWLEGEDLSEELKK------ENPFLRQELLGWLAEKLPTLRST-PTD-LILCVPHLYSCLEDR-NGDVRKKAQ 198 (240) T ss_dssp S-----HHHHSSSHHHHHHHS------SCHHHHHHHHHHHHHHGGGCSCC-CGG-GGGGHHHHHHHTTCS-SHHHHHHHH T ss_pred h-----hHhccHHHHHHHHhc------CCHHHHHHHHHHHHHHHHhCCCC-cHH-HHHHHHHHHHHHhcC-CHHHHHHHH Confidence 1 1234 555666655 36788888999998877543221 111 124567777777766 788999999 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .++..+.... T Consensus 199 ~~l~~l~~~~ 208 (240) T 4QMJ_A 199 DALPFFMMHL 208 (240) T ss_dssp HTHHHHHHHH T ss_pred HHHHHHHHHh Confidence 9998887653 No 281 >5XAH_A Importin-4; Histone, Chromatin, Assembly, PROTEIN TRANSPORT; HET: MSE; 3.004A {Homo sapiens} Probab=91.84 E-value=0.0062 Score=58.52 Aligned_cols=153 Identities=14% Similarity=0.074 Sum_probs=87.5 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-s~d~eVr~~AL~aLsnLa~~~ 626 (747) +++.+...+. +.++.++..++.+|..++..... ....+ -..+++.+...+. +.++.++..++.++..++... T Consensus 235 ~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-----~~~~~-~~~i~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~ 307 (416) T 5XAH_A 235 LLPVLLSTAQ-EADPEVRSNAIFGMGVLAEHGGH-----PAQEH-FPKLLGLLFPLLARERHDRVRDNICGALARLLMAS 307 (416) T ss_dssp HHHHHHHHTS-CSSHHHHHHHHHHHHHHHHHHHH-----HHHTT-HHHHHHHHTTHHHHCCCHHHHHHHHHHHHHHHHHC T ss_pred HHHHHHHHhh-cCCHHHHHHHHHHHHHHHHhcCc-----hHHhh-HHHHHHHHHHHhccCCCHHHHHHHHHHHHHHHHhC Confidence 4556666666 35677888888888888764321 11111 1346677777777 567788999999999888652 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA-SPKAAEAAR 705 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~-d~eVr~aAL 705 (747) .... ....+++.+...+... ......+. ++.++..+....+......+ ..+++.+...+.+.. ...++..++ T Consensus 308 ~~~~-~~~~~~~~l~~~l~~~----~~~~~~~~-~~~~l~~l~~~~~~~~~~~~-~~i~~~l~~~l~~~~~~~~~r~~~~ 380 (416) T 5XAH_A 308 PTRK-PEPQVLAALLHALPLK----EDLEEWVT-IGRLFSFLYQSSPDQVIDVA-PELLRICSLILADNKIPPDTKAALL 380 (416) T ss_dssp CSSC-CCHHHHHHHHHHCSCC----SCTTHHHH-HHHHHHHHHHHCSTTGGGSH-HHHHHTGGGTSSCTTSCHHHHHHHH T ss_pred CCCC-CHHHHHHHHHHhCCCC----CchhhHHH-HHHHHHHHHhcCchHHHhhH-HHHHHHHHHHHcCCCCCHHHHHHHH Confidence 1110 1123455555555221 01344555 77777777764332211111 134555666555431 235778888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .++..+... T Consensus 381 ~~l~~l~~~ 389 (416) T 5XAH_A 381 LLLTFLAKQ 389 (416) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHh Confidence 888877643 No 282 >5XAH_C Importin-4; Histone, Chromatin, Assembly, PROTEIN TRANSPORT; HET: MSE; 3.004A {Homo sapiens} Probab=91.84 E-value=0.0062 Score=58.52 Aligned_cols=153 Identities=14% Similarity=0.074 Sum_probs=87.3 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-s~d~eVr~~AL~aLsnLa~~~ 626 (747) +++.+...+. +.++.++..++.+|..++..... ....+ -..+++.+...+. +.++.++..++.++..++... T Consensus 235 ~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-----~~~~~-~~~i~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~ 307 (416) T 5XAH_C 235 LLPVLLSTAQ-EADPEVRSNAIFGMGVLAEHGGH-----PAQEH-FPKLLGLLFPLLARERHDRVRDNICGALARLLMAS 307 (416) T ss_dssp HHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHSHH-----HHHTT-HHHHHHHHTHHHHHCCCHHHHHHHHHHHHHHHHTS T ss_pred HHHHHHHHhh-cCCHHHHHHHHHHHHHHHHhcCc-----hHHhh-HHHHHHHHHHHhccCCCHHHHHHHHHHHHHHHHhC Confidence 4556666666 35677888888888888764321 11111 1346677777777 567788999999999888652 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA-SPKAAEAAR 705 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~-d~eVr~aAL 705 (747) .... ....+++.+...+... ......+. ++.++..+....+......+ ..+++.+...+.+.. ...++..++ T Consensus 308 ~~~~-~~~~~~~~l~~~l~~~----~~~~~~~~-~~~~l~~l~~~~~~~~~~~~-~~i~~~l~~~l~~~~~~~~~r~~~~ 380 (416) T 5XAH_C 308 PTRK-PEPQVLAALLHALPLK----EDLEEWVT-IGRLFSFLYQSSPDQVIDVA-PELLRICSLILADNKIPPDTKAALL 380 (416) T ss_dssp CC---CCHHHHHHHHHHCSCC----SCGGGHHH-HHHHHHHHHHHCHHHHTTTH-HHHHHHHHHHHSCTTSCHHHHHHHH T ss_pred CCCC-CHHHHHHHHHHhCCCC----CchhhHHH-HHHHHHHHHhcCchHHHhhH-HHHHHHHHHHHcCCCCCHHHHHHHH Confidence 1110 1123455555555221 01344555 77777777764332211111 134555666555431 235778888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .++..+... T Consensus 381 ~~l~~l~~~ 389 (416) T 5XAH_C 381 LLLTFLAKQ 389 (416) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHh Confidence 888877643 No 283 >2QK1_A Protein STU2; stu2, Stu2p, XMAP215, Dis1, TOG; 1.7A {Saccharomyces cerevisiae} Probab=91.81 E-value=0.0063 Score=53.79 Aligned_cols=152 Identities=9% Similarity=0.052 Sum_probs=95.7 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQN-LTASKGLMSSGMSQ--LIGLKEKGLPQIARLL-QSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~n-Ls~~s~~~s~~~~~--~llie~giI~~Ll~LL-~s~d~eVr~~AL~aLsnLa 623 (747) .++.+...+. +.++.++..++..|.. ++..... .. .. ....+++.+...+ .+.++.++..++.++..++ T Consensus 17 l~~~l~~~l~-~~~~~~r~~a~~~l~~~l~~~~~~-----~~~~~~-~~~~~~~~l~~~l~~d~~~~vr~~a~~~l~~l~ 89 (249) T 2QK1_A 17 LPKDFQERIT-SSKWKDRVEALEEFWDSVLSQTKK-----LKSTSQ-NYSNLLGIYGHIIQKDANIQAVALAAQSVELIC 89 (249) T ss_dssp SCTTHHHHHT-CSSHHHHHHHHHHHHHHTGGGCCC-----BCCTTC-CCHHHHHHHHHHHHHCSCHHHHHHHHHHHHHHH T ss_pred CCHHHHHHHh-CCCHHHHHHHHHHHHHHHHhcCCC-----cCCCCc-cHHHHHHHHHHHHhhCcHHHHHHHHHHHHHHHH Confidence 4556666676 4677888899999998 7754221 01 01 1245677777888 7778889999999999888 Q NP_000290.2 624 RH-PL-LHR-VMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL-AKQYFSSSMLNNIINLCRSSASPK 699 (747) Q Consensus 624 ~~-~e-~~~-ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~-~~~Lve~giL~~Ll~LL~s~~d~e 699 (747) .. .. ... .....+++.++..+.+ .+..++..++.++..+....+.. ..... ..+++.+...+.+. ++. T Consensus 90 ~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~~~~~~~~~~~~~~~-~~~~~~l~~~l~~~-~~~ 161 (249) T 2QK1_A 90 DKLKTPGFSKDYVSLVFTPLLDRTKE------KKPSVIEAIRKALLTICKYYDPLASSGRN-EDMLKDILEHMKHK-TPQ 161 (249) T ss_dssp HHHCTTTSCHHHHHHHHHHHHHGGGC------CCHHHHHHHHHHHHHHHHHSCTTCTTCTT-HHHHHHHHHHTTCS-SHH T ss_pred HHcCCCCCCHHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhChhcccCCH-HHHHHHHHHHhCCC-CHH Confidence 65 22 111 1122355666666655 35678888888888887542210 00111 23566666666655 677 Q NP_000290.2 700 AAEAARLLLSDMWSS 714 (747) Q Consensus 700 Vr~aAL~aLsnL~~~ 714 (747) ++..++.++..+... T Consensus 162 vr~~~~~~l~~~~~~ 176 (249) T 2QK1_A 162 IRMECTQLFNASMKE 176 (249) T ss_dssp HHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHh Confidence 888888888777654 No 284 >5H2V_A Importin subunit beta-3, Ubiquitin-like-specific protease; nuclear import, PROTEIN TRANSPORT-HYDROLASE complex; 2.8A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=91.79 E-value=0.0063 Score=66.66 Aligned_cols=114 Identities=16% Similarity=0.088 Sum_probs=64.4 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRS-PNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s-~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) +++.+...+.+.++.++..++.++..+...............+++.+...+.+ .+..++..++.++..++......... T Consensus 398 ~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~~~~~ 477 (1078) T 5H2V_A 398 ILDMVIPLINDPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVNFSEFASKDILE 477 (1078) T ss_dssp HHHHHGGGGGCSSHHHHHHHHHHHHHHHHHTTTHHHHHHHHHHHHHHHHTTSTTSCHHHHHHHHHHHHHHHTTCCHHHHG T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHHhhccHHHHHHHHHhHHHHHHHHcccCCCHHHHHHHHHHHHHHHhcCChhhHH Confidence 34444445555566778888888887765432211101113455555555554 45677788888888777543221101 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) .....++..+...+. ..++.++..++.++..++.. T Consensus 478 ~~~~~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~ 512 (1078) T 5H2V_A 478 PYLDSLLTNLLVLLQ-SNKLYVQEQALTTIAFIAEA 512 (1078) T ss_dssp GGHHHHHHHHHHHTT-CSSHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHh-CCCHHHHHHHHHHHHHHHHH Confidence 111245555666654 44566778888888877654 No 285 >6OWT_A AP-2 complex subunit alpha, AP-2; AP, HIV, Nef, trafficking, Protein;{Rattus norvegicus} Probab=91.69 E-value=0.0072 Score=67.72 Aligned_cols=142 Identities=13% Similarity=0.056 Sum_probs=80.2 Template_Neff=11.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSD--VVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~e--Vr~~AL~aLsnLa~~ 625 (747) .++.++.++. +.+..++..++.++..+...... ....+++.+...+.+.+.. ++..++++|+.+... T Consensus 442 ~~~~l~~~l~-~~~~~v~~~a~~~l~~i~~~~~~----------~~~~~~~~l~~~l~~~~~~~~v~~~a~~~L~~~~~~ 510 (939) T 6OWT_A 442 YVDTILNLIR-IAGDYVSEEVWYRVIQIVINRDD----------VQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNL 510 (939) T ss_pred HHHHHHHHhC-CCChhcCHHHHHHHHHHHhcCHH----------HHHhHHHHHHHHhcCCCCcHHHHHHHHHHHHHHHHh Confidence 5666777776 35556777777777776643211 1234556666667654444 778888888877654 Q NP_000290.2 626 P-LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLC---RSSASPKAA 701 (747) Q Consensus 626 ~-e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL---~s~~d~eVr 701 (747) . .........++..|...+.. .+..++..++.+|..++...+.. ...+..++..+ .+. +.+++ T Consensus 511 ~~~~~~~~~~~~~~~L~~~l~~------~~~~vr~~al~aL~~l~~~~~~~------~~~i~~ll~~l~~~~~~-d~evr 577 (939) T 6OWT_A 511 IAGDPRSSPLIQFNLLHSKFHL------CSVPTRALLLSTYIKFVNLFPEV------KATIQDVLRSDSQLKNA-DVELQ 577 (939) T ss_pred cCCCCCCCHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhChhh------HhHHHHHHHHhcccCCC-CHHHH Confidence 1 11100111244455555554 25677888888888887643221 12334444433 333 66777 Q NP_000290.2 702 EAARLLLSDMWS 713 (747) Q Consensus 702 ~aAL~aLsnL~~ 713 (747) ..++.++..+.. T Consensus 578 ~~a~~~l~~l~~ 589 (939) T 6OWT_A 578 QRAVEYLRLSTV 589 (939) T ss_pred HHHHHHHHHHcC Confidence 777777766553 No 286 >2P8Q_A Importin beta-1 subunit, Snurportin-1; HEAT repeat, IBB-domain, Importin, Karyopherin; 2.35A {Homo sapiens} SCOP: a.118.1.1 Probab=91.69 E-value=0.0066 Score=64.52 Aligned_cols=160 Identities=8% Similarity=0.007 Sum_probs=89.0 Template_Neff=13.100 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG--NSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~--d~eVr~~AL~aLsnLa~~ 625 (747) .++.++..+..+.++.++..++.+|..++..... ....+ -..+++.+...+.+. ++.++..++.++..++.. T Consensus 650 ~~~~l~~~l~~~~~~~vr~~~~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~~~v~~~a~~~l~~l~~~ 723 (876) T 2P8Q_A 650 FKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQS-----NIIPF-CDEVMQLLLENLGNENVHRSVKPQILSVFGDIALA 723 (876) T ss_dssp HHHHHHHHHHCCSSHHHHHHHHHHHHHHHHHHGG-----GGHHH-HHHHHHHHHHHTSCSSSCTTHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHhccccHHHHHHHHHHHHHHHHHHhh-----cchHh-HHHHHHHHHHHHcCcCcccchHhHHHHHHHHHHHH Confidence 3455555555225667888888888888754221 01111 135677777777766 678888999999888865 Q NP_000290.2 626 -PLL-HRVMGNQVFPEVTRLLTSHTG-----NTSNSEDILSSACYTVRNLMASQPQLAKQYFS-----SSMLNNIINLCR 693 (747) Q Consensus 626 -~e~-~~ll~~giI~~Ll~LL~s~s~-----~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve-----~giL~~Ll~LL~ 693 (747) ... ..++ ..+++.+...+..... ....+..++..++.++..++.........+.. ...++.++..+. T Consensus 724 ~~~~~~~~~-~~~~~~l~~~l~~~~~~~~~~~~~~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~ 802 (876) T 2P8Q_A 724 IGGEFKKYL-EVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFID 802 (876) T ss_dssp HGGGGHHHH-HHHHHHHHHHHSCCCCTTCSTTHHHHHHHHHHHHHHHHHHHHHHSCSSCSCCCGGGGTGGGHHHHHHHHH T ss_pred hchhhHHHH-HHHHHHHHHHHHccCCCCchHHHHHHHHHHHHHHHHHHHHHHHHhcCcccCCCchhhHHHhHHHHHHHHH Confidence 211 1111 2345555555443100 00014667888888888887621111111100 011444444443 Q NP_000290.2 694 ------SSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 694 ------s~~d~eVr~aAL~aLsnL~~~~ 715 (747) +. +..++..++.++..++..- T Consensus 803 ~~~~~~~~-~~~v~~~~~~~l~~l~~~~ 829 (876) T 2P8Q_A 803 HIAGDEDH-TDGVVACAAGLIGDLCTAF 829 (876) T ss_dssp HHHHSSCC-CHHHHHHHHHHHHHHHHHH T ss_pred HHhCCCCC-ChhHHHHHHHHHHHHHHHh Confidence 33 5778888888888877543 No 287 >5MFO_F YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: CA, EDO; 1.3A {synthetic construct} Probab=91.65 E-value=0.0068 Score=51.30 Aligned_cols=157 Identities=18% Similarity=0.285 Sum_probs=121.2 Template_Neff=13.100 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .+.++.++..+. +.++.++..++..|.+++...+. ....+.+.++++.|..++.+.++.++..++++|.+++.. T Consensus 3 ~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~ 76 (202) T 5MFO_F 3 GSELPQMVQQLN-SPDQQELQSALRKLSQIASGGNE-----QIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASG 76 (202) T ss_dssp CTTHHHHHHHTT-CSCHHHHHHHHHHHHHHHTSCHH-----HHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTS T ss_pred CchHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCChH-----HHHHHHHCChHHHHHHHhcCCCHHHHHHHHHHHHHHhcC Confidence 456788888887 47778888999999999875332 233445678899999999988889999999999999976 Q NP_000290.2 626 -PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 626 -~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) ... ..+...++++.+..++.+ .++.++..++.+|.+++...+.....+.+.++++.+..++.+. +..++.. T Consensus 77 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~ 149 (202) T 5MFO_F 77 GNEQIQAVIDAGALPALVQLLSS------PNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSP-NEQILQE 149 (202) T ss_dssp CHHHHHHHHHTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCS-CHHHHHH T ss_pred CHHHHHHHHHCChHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCC-CHHHHHH Confidence 333 334455678888888866 3678888999999999876455555556667888888888866 7888999 Q NP_000290.2 704 ARLLLSDMWSSK 715 (747) Q Consensus 704 AL~aLsnL~~~~ 715 (747) ++.+|.+++... T Consensus 150 ~~~~l~~l~~~~ 161 (202) T 5MFO_F 150 ALWALSNIASGG 161 (202) T ss_dssp HHHHHHHHTTSC T ss_pred HHHHHHHHhcCh Confidence 999999998765 No 288 >5MFO_E YIIIM3AIII; Designed armadillo repeat protein, peptide; HET: EDO, CA; 1.3A {synthetic construct} Probab=91.58 E-value=0.007 Score=51.19 Aligned_cols=157 Identities=18% Similarity=0.285 Sum_probs=120.0 Template_Neff=13.100 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .+.++.++..+. +.++.++..++..|.+++...+. ....+.+.++++.|..++.+.++.++..++++|.+++.. T Consensus 3 ~~~~~~l~~~l~-~~~~~~~~~a~~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~~~a~~~l~~l~~~ 76 (202) T 5MFO_E 3 GSELPQMVQQLN-SPDQQELQSALRKLSQIASGGNE-----QIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASG 76 (202) T ss_dssp --CHHHHHHHTT-CSSHHHHHHHHHHHHHHHTSCHH-----HHHHHHHTTHHHHHHHHTTCSCHHHHHHHHHHHHHHTTS T ss_pred CchHHHHHHHhc-CCCHHHHHHHHHHHHHHHcCChH-----HHHHHHHCChHHHHHHHhhCCCHHHHHHHHHHHHHHhcC Confidence 456788888887 47778888999999999875332 233445678899999999988889999999999999976 Q NP_000290.2 626 -PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 626 -~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) +.. ..+...++++.+...+.+ .++.++..++.+|.+++...+.....+.+.++++.+..++.+. +..++.. T Consensus 77 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~ 149 (202) T 5MFO_E 77 GNEQIQAVIDAGALPALVQLLSS------PNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSP-NEQILQE 149 (202) T ss_dssp CHHHHHHHHHTTHHHHHHHHTTC------SCHHHHHHHHHHHHHHTTSCHHHHHHHHHTTHHHHHHHHTTCS-CHHHHHH T ss_pred CHHHHHHHHHCChHHHHHHHhcC------CCHHHHHHHHHHHHHHHcCCHHHHHHHHHCCHHHHHHHHhcCC-CHHHHHH Confidence 333 333455678888888866 3678888999999999876455555555667888888888876 7888999 Q NP_000290.2 704 ARLLLSDMWSSK 715 (747) Q Consensus 704 AL~aLsnL~~~~ 715 (747) ++.+|.+++... T Consensus 150 ~~~~l~~l~~~~ 161 (202) T 5MFO_E 150 ALWALSNIASGG 161 (202) T ss_dssp HHHHHHHHHTSC T ss_pred HHHHHHHHhcCH Confidence 999999998765 No 289 >2QNA_A Importin subunit beta-1, Snurportin-1; Nuclear transport, import of spliceosomal; HET: SO4; 2.84A {Homo sapiens} Probab=91.50 E-value=0.0073 Score=62.82 Aligned_cols=159 Identities=8% Similarity=0.020 Sum_probs=86.8 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG--NSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~--d~eVr~~AL~aLsnLa~~ 625 (747) .++.+...+....++.++..++.++..++..... ....+ -..+++.+...+.+. ++.++..++.++..++.. T Consensus 525 ~~~~l~~~l~~~~~~~v~~~a~~~l~~l~~~~~~-----~~~~~-~~~i~~~l~~~l~~~~~~~~v~~~~~~~l~~l~~~ 598 (762) T 2QNA_A 525 FKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQS-----NIIPF-CDEVMQLLLENLGNENVHRSVKPQILSVFGDIALA 598 (762) T ss_pred HHHHHHHHhCCCCCHHHHHHHHHHHHHHHHHhHH-----cchHh-HHhHHHHHHHHHcCCCCCHHHHHHHHHHHHHHHHH Confidence 4555665565224567788888888888754221 01111 135667777777765 567888899999888765 Q NP_000290.2 626 -PLL-HRVMGNQVFPEVTRLLTSHTGN-----TSNSEDILSSACYTVRNLMASQPQLAKQYFS-----SSMLNNIINLCR 693 (747) Q Consensus 626 -~e~-~~ll~~giI~~Ll~LL~s~s~~-----~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve-----~giL~~Ll~LL~ 693 (747) ... ..++ ..+++.+...+...... ...+..++..++.++..++...+.....+.. ...++.++.++. T Consensus 599 ~~~~~~~~~-~~i~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~l~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~ 677 (762) T 2QNA_A 599 IGGEFKKYL-EVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFID 677 (762) T ss_pred hhcchHHHH-HHHHHHHHHHHcCCCCCCCcccCCCCHHHHHHHHHHHHHHHHhCCCCCcCccccHHHHHhHHHHHHHHHH Confidence 211 1111 23445555554421000 0014566778888888887642221111100 011344444443 Q NP_000290.2 694 ------SSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 694 ------s~~d~eVr~aAL~aLsnL~~~ 714 (747) +. +..++..++.+|..++.. T Consensus 678 ~~~~~~~~-~~~~~~~a~~~l~~l~~~ 703 (762) T 2QNA_A 678 HIAGDEDH-TDGVVACAAGLIGDLCTA 703 (762) T ss_pred HHcCCCCC-CHHHHHHHHHHHHHHHHH Confidence 22 467788888888887754 No 290 >6G4J_B Probable serine/threonine-protein kinase YabT (E.C.2.7.11.1); Bacterial Hanks-type protein kinase, complex; 1.599A {Bacillus subtilis (strain 168)} Probab=91.47 E-value=0.008 Score=50.62 Aligned_cols=132 Identities=14% Similarity=0.147 Sum_probs=85.5 Template_Neff=11.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) ..+.+++++. +.++.++..++..+..+.. ...++.+..++.+.++.++..++.++..+... T Consensus 15 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~----------------~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~-- 75 (148) T 6G4J_B 15 KVEMYIKNLQ-DDSAVVRDYAAAALGKIGD----------------ERAVEPLIKALKDEDEYVRQSAAWALGEIGDE-- 75 (148) T ss_pred cHHHHHHHhc-CCCHHHHHHHHHHHHhhCC----------------HHHHHHHHHHhCCCCHHHHHHHHHHHHHhCCH-- Confidence 4566777777 4667777777777765532 12344556667677788888888888877542 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ..++.+...+.+ .++.++..++.++..+... ..++.+..++.+. ++.++..++.+ T Consensus 76 -------~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~vr~~a~~~ 130 (148) T 6G4J_B 76 -------RAVEPLIKALKD------EDPSVRLTAAEALGQIGGE-----------RVRAAMEKLAETG-TGFARKVAVNY 130 (148) T ss_pred -------HHHHHHHHHhcC------CCHHHHHHHHHHHHhhCCH-----------HHHHHHHHHhcCC-CHHHHHHHHHH Confidence 234455555554 3567888888888876531 2344555566555 67888999999 Q NP_000290.2 708 LSDMWSSKELQGVLRQ 723 (747) Q Consensus 708 LsnL~~~~~~~~~~~~ 723 (747) |..+........-+++ T Consensus 131 L~~~~~~~~~~~~~~~ 146 (148) T 6G4J_B 131 LETHKSLISGGGGSGG 146 (148) T ss_pred HHhhCCCChHhccccc Confidence 9888766555444443 No 291 >3W3W_A Importin subunit beta-3, Protein STE12; HEAT repeat, nuclear import, PROTEIN; 2.2A {Saccharomyces cerevisiae} Probab=91.29 E-value=0.0081 Score=65.72 Aligned_cols=98 Identities=9% Similarity=0.152 Sum_probs=58.6 Template_Neff=13.000 Q NP_000290.2 609 SDVVRSGASLLSNMSRHPL-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLN 686 (747) Q Consensus 609 ~eVr~~AL~aLsnLa~~~e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~ 686 (747) ..++..++.++..++.... . .... ..+++.+...+.+ .++.++..++.+|..++...+...... ...+++ T Consensus 821 ~~~~~~~~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~------~~~~~r~~a~~~l~~l~~~~~~~~~~~-~~~~~~ 892 (1078) T 3W3W_A 821 EDLLDEINKSIAAVLKTTNGHYLKNL-ENIWPMINTFLLD------NEPILVIFALVVIGDLIQYGGEQTASM-KNAFIP 892 (1078) T ss_dssp HHHHHHHHHHHHHHHHHHTTTHHHHH-GGGHHHHHHHHC--------CHHHHHHHHHHHHHHHTC--CCCHHH-HHHHHH T ss_pred HHHHHHHHHHHHHHHHhcccchHHHH-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhcchhhHHH-HHhHHH Confidence 3455666677776665411 1 1111 2345556666554 356788888899988876432221111 124567 Q NP_000290.2 687 NIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 687 ~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .+...+.+. ++.++..++.+|..++... T Consensus 893 ~l~~~l~~~-~~~vr~~a~~~l~~l~~~~ 920 (1078) T 3W3W_A 893 KVTECLISP-DARIRQAASYIIGVCAQYA 920 (1078) T ss_dssp HHHHHHTCS-CHHHHHHHHHHHHHHHHHS T ss_pred HHHHHhcCC-CHHHHHHHHHHHHHHHHHC Confidence 777777766 7889999999998888653 No 292 >3ND2_A Importin subunit beta-1; importin, karyopherin, nuclear import, receptor; 2.4A {Saccharomyces cerevisiae} Probab=91.23 E-value=0.0083 Score=63.25 Aligned_cols=152 Identities=13% Similarity=0.136 Sum_probs=86.1 Template_Neff=13.300 Q NP_000290.2 548 AIRTYLNLMGKSKK-DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d-~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) .++.+...+.. .+ ..++..++.++..++..... .... .-..+++.+...+.+.++.++..++.++..++.. T Consensus 598 ~~~~l~~~l~~-~~~~~v~~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~ 670 (861) T 3ND2_A 598 LMGLFFRLLEK-KDSAFIEDDVFYAISALAASLGK-----GFEK-YLETFSPYLLKALNQVDSPVSITAVGFIADISNSL 670 (861) T ss_dssp HHHHHHHHHHS-TTHHHHHHHHHHHHHHHHHHHGG-----GGGG-GHHHHHHHHHHHHTCTTSTHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHhc-CCCchhHHHHHHHHHHHHHHhhh-----hHHH-HHHhHHHHHHHHHcCCCchHHHHHHHHHHHHHHHc Confidence 45555666652 33 55777888888887754221 0111 1235677777777777778888999999988865 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASP------ 698 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~------ 698 (747) +.. .... ..+++.+...+... ..+..++..++.++..++...+....... ..+++.+...+... .. T Consensus 671 ~~~~~~~~-~~~~~~l~~~l~~~----~~~~~~r~~a~~~l~~l~~~~~~~~~~~~-~~i~~~l~~~l~~~-~~~~~~~~ 743 (861) T 3ND2_A 671 EEDFRRYS-DAMMNVLAQMISNP----NARRELKPAVLSVFGDIASNIGADFIPYL-NDIMALCVAAQNTK-PENGTLEA 743 (861) T ss_dssp TTSSHHHH-HHHHHHHHHHHHCT----TCCTTHHHHHHHHHHHHHHHHGGGGGGGH-HHHHHHHHHHHTCC-CSSSSHHH T ss_pred chhhHHhH-HHHHHHHHHHHhCc----chhhhhHHHHHHHHHHHHHHcchhcHHHH-HHHHHHHHHHHccC-CCCCCHHH Confidence 211 1111 23555555555541 01467788888999888765332111111 23455555555433 21 Q NP_000290.2 699 -----KAAEAARLLLSDMWS 713 (747) Q Consensus 699 -----eVr~aAL~aLsnL~~ 713 (747) .++..++.++..++. T Consensus 744 ~~~~~~~~~~~l~~l~~~~~ 763 (861) T 3ND2_A 744 LDYQIKVLEAVLDAYVGIVA 763 (861) T ss_dssp HHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHH Confidence 455566666655443 No 293 >5OWU_A Importin subunit beta-1, Nucleoporin NUP1; nuclear transport, TRANSPORT PROTEIN; 2.0A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=91.23 E-value=0.0083 Score=63.25 Aligned_cols=152 Identities=13% Similarity=0.136 Sum_probs=86.1 Template_Neff=13.300 Q NP_000290.2 548 AIRTYLNLMGKSKK-DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d-~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) .++.+...+.. .+ ..++..++.++..++..... .... .-..+++.+...+.+.++.++..++.++..++.. T Consensus 598 ~~~~l~~~l~~-~~~~~v~~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~ 670 (861) T 5OWU_A 598 LMGLFFRLLEK-KDSAFIEDDVFYAISALAASLGK-----GFEK-YLETFSPYLLKALNQVDSPVSITAVGFIADISNSL 670 (861) T ss_dssp HHHHHHHHHHS-TTGGGTHHHHHHHHHHHHHHHGG-----GGGG-GHHHHHHHHHHHHHCTTSTHHHHHHHHHHHHHHHS T ss_pred HHHHHHHHHhc-CCCchhHHHHHHHHHHHHHHhhh-----hHHH-HHHhHHHHHHHHHcCCCchHHHHHHHHHHHHHHHc Confidence 45555666652 33 55777888888887754221 0111 1235677777777777778888999999988865 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASP------ 698 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~------ 698 (747) +.. .... ..+++.+...+... ..+..++..++.++..++...+....... ..+++.+...+... .. T Consensus 671 ~~~~~~~~-~~~~~~l~~~l~~~----~~~~~~r~~a~~~l~~l~~~~~~~~~~~~-~~i~~~l~~~l~~~-~~~~~~~~ 743 (861) T 5OWU_A 671 EEDFRRYS-DAMMNVLAQMISNP----NARRELKPAVLSVFGDIASNIGADFIPYL-NDIMALCVAAQNTK-PENGTLEA 743 (861) T ss_dssp GGGGHHHH-HHHHHHHHHHHTCT----TCCTTHHHHHHHHHHHHHHHHGGGGHHHH-HHHHHHHHHHHTCC-CSSSSHHH T ss_pred chhhHHhH-HHHHHHHHHHHhCc----chhhhhHHHHHHHHHHHHHHcchhcHHHH-HHHHHHHHHHHccC-CCCCCHHH Confidence 211 1111 23555555555541 01467788888999888765332111111 23455555555433 21 Q NP_000290.2 699 -----KAAEAARLLLSDMWS 713 (747) Q Consensus 699 -----eVr~aAL~aLsnL~~ 713 (747) .++..++.++..++. T Consensus 744 ~~~~~~~~~~~l~~l~~~~~ 763 (861) T 5OWU_A 744 LDYQIKVLEAVLDAYVGIVA 763 (861) T ss_dssp HHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHH Confidence 455566666655443 No 294 >5DFZ_B Vacuolar protein sorting-associated protein 38; Vps34, Vps15, Vps30, Vps38, Autophagy; 4.4A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=90.97 E-value=0.011 Score=70.63 Aligned_cols=159 Identities=14% Similarity=0.083 Sum_probs=104.1 Template_Neff=9.900 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATL-EACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL---QSGNSDVVRSGASLLSN 621 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr-~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL---~s~d~eVr~~AL~aLsn 621 (747) ..+++.|+.+|. +.++.++ ..|+.+|..+...... ......+...++++.|+.+| .+.++.++..++.+|.. T Consensus 463 ~~~i~~L~~~l~-d~~~~vR~~~a~~~L~~l~~~~~~---~~~~~~~~~~~~lp~Li~~L~~~~d~~~~vr~~aa~~l~~ 538 (1460) T 5DFZ_B 463 DRVVPYFVCCFE-DSDQDVQALSLLTLIQVLTSVRKL---NQLNENIFVDYLLPRLKRLLISNRQNTNYLRIVFANCLSD 538 (1460) T ss_pred ccchHHHHHHhc-CCCHHHHHHHHHHHHHHhcCCCCc---cCCccccCcCChHHHHHHHHHhccCCCHHHHHHHHHHHHH Confidence 457888999998 5788888 8999999988764221 00011223467899999999 88889999999999998 Q NP_000290.2 622 MSRHP--L-----------L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNN 687 (747) Q Consensus 622 La~~~--e-----------~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~ 687 (747) +.... . . ...+..++++.+..++...- ...++.++..|+.+|..|+...... .....+++. T Consensus 539 ~~~~~~~~~l~~l~~~~~~~~~~~l~~~~~~~l~~ll~~~l--~d~~~~VR~~A~~aL~~l~~~~~~~---~~~~~~l~~ 613 (1460) T 5DFZ_B 539 LAIIINRFQEFTFAQHCNDNSSTKYSAKLIQSVEDLTVSFL--TDNDTYVKMALLQNILPLCKFFGRE---RTNDIILSH 613 (1460) T ss_pred HHHHcCHHHHHHHHHhcccChhHHHHcChHHHHHHHHHHHh--cCCCHHHHHHHHHHHHHHhcccccc---ccHHhHHHH Confidence 85430 0 0 01122234444444433200 0036789999999999987542111 111356778 Q NP_000290.2 688 IINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 688 Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) |+.++.+. ++.+|..|+.+|..+... T Consensus 614 Li~ll~d~-~~~VR~~a~~aL~~i~~~ 639 (1460) T 5DFZ_B 614 LITYLNDK-DPALRVSLIQTISGISIL 639 (1460) T ss_pred HHHHhcCC-CHHHHHHHHHHHHHHHhh Confidence 88888776 788888888888888763 No 295 >3W3U_A Importin subunit beta-3; HEAT repeat, nuclear import, PROTEIN; 2.6A {Saccharomyces cerevisiae} Probab=90.68 E-value=0.011 Score=64.69 Aligned_cols=157 Identities=9% Similarity=0.025 Sum_probs=84.5 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.++..+..+.+..++..++.+|..++..... . .... .-..+++.+...+.+.++.++..++.+|..++.... T Consensus 440 ~~~~l~~~l~~~~~~~vr~~a~~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~ 514 (1078) T 3W3U_A 440 ILPALISKLTSECTSRVQTHAAAALVAFSEFASK---D-ILEP-YLDSLLTNLLVLLQSNKLYVQEQALTTIAFIAEAAK 514 (1078) T ss_dssp HHHHHHHHSSTTSCHHHHHHHHHHHHHHHTTCCH---H-HHGG-GHHHHHHHHHHHHTCSSHHHHHHHHHHHHHHHHHHG T ss_pred HHHHHHHHcCCCCCHHHHHHHHHHHHHHHHhCCh---h-hhHH-HHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHhH Confidence 4555666665224566777888888888764221 0 0111 123566677777777778888899999988876521 Q NP_000290.2 628 -LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR---SSASPKAAEA 703 (747) Q Consensus 628 -~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~---s~~d~eVr~a 703 (747) ........+++.+...+.... ..++.++..++.++..+................++.+..++. +. +..++.. T Consensus 515 ~~~~~~~~~~~~~l~~~l~~~~---~~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~-~~~~~~~ 590 (1078) T 3W3U_A 515 NKFIKYYDTLMPLLLNVLKVNN---KDNSVLKGKCMECATLIGFAVGKEKFHEHSQELISILVALQNSDIDE-DDALRSY 590 (1078) T ss_dssp GGGGGGHHHHHHHHHHHHHCC-------HHHHHHHHHHHHHHHHHHCHHHHTTTHHHHHHHHHHHHTSSCCC-CHHHHHH T ss_pred HhHHHHHhhHHHHHHHHHhcCC---CCcchHHHHHHHHHHHHHHHHCHHHhHHHHHHHHHHHHHHhcCCCCC-CHHHHHH Confidence 111111234555555554310 014567777888888776532111100011123444444444 23 4566777 Q NP_000290.2 704 ARLLLSDMWS 713 (747) Q Consensus 704 AL~aLsnL~~ 713 (747) ++.++..++. T Consensus 591 ~~~~l~~l~~ 600 (1078) T 3W3U_A 591 LEQSWSRICR 600 (1078) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 7777766654 No 296 >1QGR_A IMPORTIN BETA SUBUNIT, IMPORTIN ALPHA-2; TRANSPORT RECEPTOR, NUCLEAR IMPORT, HEAT; 2.3A {Homo sapiens} SCOP: a.118.1.1 Probab=90.57 E-value=0.011 Score=62.78 Aligned_cols=113 Identities=11% Similarity=0.140 Sum_probs=66.6 Template_Neff=13.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL-E 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~-~ 324 (747) +++.+...+.+.++.++..++.++..++..............+++.+...+.+.+..++..++.++..++........ . T Consensus 367 ~~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~ 446 (876) T 1QGR_A 367 VLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAIND 446 (876) T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHHHHHcCCHHhcHHHHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHhCChhhcCC Confidence 344444555556677788888888887764322111111234556666666666778888899998888764432110 1 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) .....+++.+...+. + ++.++..++.++..+... T Consensus 447 ~~~~~~~~~l~~~l~-~-~~~v~~~a~~~l~~l~~~ 480 (876) T 1QGR_A 447 VYLAPLLQCLIEGLS-A-EPRVASNVCWAFSSLAEA 480 (876) T ss_pred chHHHHHHHHHHHhc-C-CHHHHHHHHHHHHHHHHH Confidence 112245566666665 3 566777777777777653 No 297 >4QMH_A LP04448p; PROTEIN BINDING, TOG DOMAIN; 1.652A {Drosophila melanogaster} Probab=90.39 E-value=0.012 Score=51.77 Aligned_cols=149 Identities=9% Similarity=0.047 Sum_probs=95.9 Template_Neff=12.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... .... .-..+++.+...+.+.+..++..++.+|..++.... T Consensus 58 ~~~~l~~~l~-d~~~~v~~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 130 (241) T 4QMH_A 58 LAPALAHRLV-DSNAKIAQTTLAICEQLATAMGA-----GCRN-HVRNLFPGFLHALGDNKSFVRAAALNCINSFGEKGG 130 (241) T ss_dssp HHHHHHHHHT-CSSHHHHHHHHHHHHHHHHHHGG-----GGGG-GHHHHHHHHHHHTTCSSHHHHHHHHHHHHHHHHHHC T ss_pred HHHHHHHHHc-CCCHHHHHHHHHHHHHHHHHhcH-----HHHH-HHHHHHHHHHHHhcCCcHHHHHHHHHHHHHHHHhcC Confidence 4556666676 46778888999999988764221 1111 113566777777777777788888888888775421 Q NP_000290.2 628 LHRVMGNQVFPE--VTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK-QYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 628 ~~~ll~~giI~~--Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~-~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . ..+++. +...+.+ .++.++..++.++..++...+.... ......+++.+...+.+. ++.++..+ T Consensus 131 ~-----~~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~vr~~a 198 (241) T 4QMH_A 131 Y-----KEFFESEMIADALKG------GSPALKTELWAWLADKLPGLPPKSVSKEDIHSMVPHLYAHICDR-NADVRKNA 198 (241) T ss_dssp S-----GGGSSTTHHHHHHHT------CCHHHHHHHHHHHHHHGGGSCGGGSCHHHHHHHHHHHHHHTTCS-SHHHHHHH T ss_pred h-----HHhcCHHHHHHHHhC------CCHHHHHHHHHHHHHhccCCCcccCCHHHHHhHHHHHHHHHhCC-CHHHHHHH Confidence 1 123333 5555554 3677888899999888764322110 011124567777777766 78899999 Q NP_000290.2 705 RLLLSDMWSSK 715 (747) Q Consensus 705 L~aLsnL~~~~ 715 (747) +.++..+.... T Consensus 199 ~~~l~~l~~~~ 209 (241) T 4QMH_A 199 NEAVLGIMIHL 209 (241) T ss_dssp HHHHHHHHHHH T ss_pred HHHHHHHHHHh Confidence 99998887543 No 298 >5A1V_E ADP-RIBOSYLATION FACTOR 1, COATOMER SUBUNIT; TRANSPORT PROTEIN, COPI, COATOMER, COATED; 21.0A {SACCHAROMYCES CEREVISIAE} Probab=90.35 E-value=0.013 Score=64.93 Aligned_cols=102 Identities=12% Similarity=0.008 Sum_probs=64.4 Template_Neff=10.900 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..++..+...+.+.+..++..+..++..+....+.. ..+++.+...+.+.+..++..++.++..+.... T Consensus 67 ~~l~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~------~~i~~~l~~~L~~~~~~vr~~al~~L~~~~~~~----- 135 (874) T 5A1V_E 67 TEAFFAMTKLFQSNDPTLRRMCYLTIKEMSCIAEDV------IIVTSSLTKDMTGKEDNYRGPAVRALCQITDST----- 135 (874) T ss_dssp HHHHHHHHHGGGSCCHHHHHHHHHHHHHHHTSCSCG------GGHHHHHHHHHHSSSHHHHHHHHHHHHHHCCHH----- T ss_pred HHHHHHHHHHHcCCCHHHHHHHHHHHHHhcccCchH------hHHHHHHHHhcCCCChhhHHHHHHHHhhcCCHH----- Confidence 345556666677777788888888887776532211 234555666666667778888888887664211 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ....++..+...+. +.++.++..++.++..+.. T Consensus 136 --~~~~l~~~l~~~l~-d~~~~Vr~~a~~~l~~l~~ 168 (874) T 5A1V_E 136 --MLQAVERYMKQAIV-DKVPSVSSSALVSSLHLLK 168 (874) T ss_dssp --HHHHHHHHHHHHHT-CSSHHHHHHHHHHHHHHHH T ss_pred --HHHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHh Confidence 01234455555665 5567788888888887765 No 299 >5NZR_G Coatomer subunit alpha, Coatomer subunit; COPI, coatomer, coated vesicles, Transport; 9.2A {Mus musculus} Probab=90.35 E-value=0.013 Score=64.93 Aligned_cols=102 Identities=12% Similarity=0.008 Sum_probs=64.4 Template_Neff=10.900 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..++..+...+.+.+..++..+..++..+....+.. ..+++.+...+.+.+..++..++.++..+.... T Consensus 67 ~~l~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~------~~i~~~l~~~L~~~~~~vr~~al~~L~~~~~~~----- 135 (874) T 5NZR_G 67 TEAFFAMTKLFQSNDPTLRRMCYLTIKEMSCIAEDV------IIVTSSLTKDMTGKEDNYRGPAVRALCQITDST----- 135 (874) T ss_pred HHHHHHHHHHHcCCCHHHHHHHHHHHHHhcccCchH------hHHHHHHHHhcCCCChhhHHHHHHHHhhcCCHH----- Confidence 345556666677777788888888887776532211 234555666666667778888888887664211 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ....++..+...+. +.++.++..++.++..+.. T Consensus 136 --~~~~l~~~l~~~l~-d~~~~Vr~~a~~~l~~l~~ 168 (874) T 5NZR_G 136 --MLQAVERYMKQAIV-DKVPSVSSSALVSSLHLLK 168 (874) T ss_pred --HHHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHh Confidence 01234455555665 5567788888888887765 No 300 >3W3W_A Importin subunit beta-3, Protein STE12; HEAT repeat, nuclear import, PROTEIN; 2.2A {Saccharomyces cerevisiae} Probab=90.26 E-value=0.013 Score=64.05 Aligned_cols=157 Identities=10% Similarity=0.054 Sum_probs=83.5 Template_Neff=13.000 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.++..+....++.++..++.+|..++..... . .... .-..+++.+...+.+.++.++..++.++..++... T Consensus 439 ~~~~~l~~~l~~~~~~~~r~~a~~~l~~l~~~~~~---~-~~~~-~~~~i~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~ 513 (1078) T 3W3W_A 439 RILPALISKLTSECTSRVQTHAAAALVNFSEFASK---D-ILEP-YLDSLLTNLLVLLQSNKLYVQEQALTTIAFIAEAA 513 (1078) T ss_dssp HHHHHHHHHTSTTSCHHHHHHHHHHHHHHHHTCCH---H-HHGG-GHHHHHHHHHHHHTCSSHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHcccCCCHHHHHHHHHHHHHHHhcCCh---h-hHHH-HHHHHHHHHHHHHhcCCHHHHHHHHHHHHHHHHHh Confidence 35566666665224567778888888887764221 0 0011 11355666777777667788888999998887652 Q NP_000290.2 627 L-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP-QLAKQYFSSSMLNNIINLCR---SSASPKA 700 (747) Q Consensus 627 e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~-e~~~~Lve~giL~~Ll~LL~---s~~d~eV 700 (747) . . .... ..+++.+...+.... ..++.++..++.++..++.... ...... ...++..+...+. +. +..+ T Consensus 514 ~~~~~~~~-~~~~~~l~~~l~~~~---~~~~~~~~~~~~~l~~l~~~~~~~~~~~~-~~~~~~~l~~~l~~~~~~-~~~v 587 (1078) T 3W3W_A 514 KNKFIKYY-DTLMPLLLNVLKVNN---KDNSVLKGKCMECATLIGFAVGKEKFHEH-SQELISILVALQNSDIDE-DDAL 587 (1078) T ss_dssp GGGGGGGH-HHHHHHHHHHHHCC-------HHHHHHHHHHHHHHHHHHCHHHHTTT-HHHHHHHHHHHHTCC------HH T ss_pred HHhHHHHH-HhHHHHHHHHHHhCC---CCChHHHHHHHHHHHHHHHHHChhhhhHH-HHHHHHHHHHHhCCCCCC-chHH Confidence 1 1 1111 234555555554310 0145677778888888765321 111111 1123444444444 23 4566 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..++.. T Consensus 588 ~~~~~~~l~~l~~~ 601 (1078) T 3W3W_A 588 RSYLEQSWSRICRI 601 (1078) T ss_dssp HHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH Confidence 77777777666543 No 301 >5H2V_A Importin subunit beta-3, Ubiquitin-like-specific protease; nuclear import, PROTEIN TRANSPORT-HYDROLASE complex; 2.8A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=90.24 E-value=0.013 Score=64.03 Aligned_cols=158 Identities=9% Similarity=0.045 Sum_probs=84.1 Template_Neff=13.000 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.++..+....++.++..++.+|..++..... . .... .-..+++.+...+.+.++.++..++.++..++... T Consensus 439 ~~~~~l~~~l~~~~~~~~~~~a~~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~l~~~~ 513 (1078) T 5H2V_A 439 RILPALISKLTSECTSRVQTHAAAALVNFSEFASK---D-ILEP-YLDSLLTNLLVLLQSNKLYVQEQALTTIAFIAEAA 513 (1078) T ss_dssp HHHHHHHHTTSTTSCHHHHHHHHHHHHHHHTTCCH---H-HHGG-GHHHHHHHHHHHTTCSSHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHcccCCCHHHHHHHHHHHHHHHhcCCh---h-hHHH-HHHHHHHHHHHHHhCCCHHHHHHHHHHHHHHHHHh Confidence 35566666665224567778888888888764221 0 0011 12356666777777677788889999998887652 Q NP_000290.2 627 L-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR---SSASPKAA 701 (747) Q Consensus 627 e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~---s~~d~eVr 701 (747) . . .... ..+++.+...+.... ..++.++..++.++..++..............+++.+...+. +. +..++ T Consensus 514 ~~~~~~~~-~~~~~~l~~~l~~~~---~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~-~~~v~ 588 (1078) T 5H2V_A 514 KNKFIKYY-DTLMPLLLNVLKVNN---KDNSVLKGKCMECATLIGFAVGKEKFHEHSQELISILVALQNSDIDE-DDALR 588 (1078) T ss_dssp GGGGGGGH-HHHHHHHHHHHTCC-------HHHHHHHHHHHHHHHHHHCHHHHTTTHHHHHHHHHHHHTCC------CHH T ss_pred HHHHHHHH-HhHHHHHHHHHHhCC---CCChHHHHHHHHHHHHHHHHHCchhhhHHHHHHHHHHHHHhCCCCCC-chHHH Confidence 1 1 1111 234555555554310 014567778888888876532111000011123444444444 23 45666 Q NP_000290.2 702 EAARLLLSDMWSS 714 (747) Q Consensus 702 ~aAL~aLsnL~~~ 714 (747) ..++.++..++.. T Consensus 589 ~~~~~~l~~l~~~ 601 (1078) T 5H2V_A 589 SYLEQSWSRICRI 601 (1078) T ss_dssp HHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHH Confidence 7777777666543 No 302 >4NEE_G AP-2 complex subunit sigma, AP-2; clathrin Adaptor AP-2, HIV-1 Nef; 2.8841A {Rattus norvegicus} Probab=90.08 E-value=0.014 Score=56.75 Aligned_cols=141 Identities=15% Similarity=0.147 Sum_probs=95.0 Template_Neff=12.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++.++. ++++.++..++.+|..+....+. . ...+++.+...+.+.++.++..++.+++.+..... T Consensus 77 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~al~~l~~~~~~~~ 145 (398) T 4NEE_G 77 GHMEAVNLLS-SNRYTEKQIGYLFISVLVNSNSE--------L--IRLINNAIKNDLASRNPTFMGLALHCIANVGSREM 145 (398) T ss_dssp CHHHHHHHHT-CSSHHHHHHHHHHHHHSCCCCHH--------H--HHHHHHHHHHHHHSCCHHHHHHHHHHHHHHCCHHH T ss_pred hHHHHHHHHc-CCCccHHHHHHHHHHHHcCCCHH--------H--HHHHHHHHHHHHhCCCHHHHHHHHHHHHhcCCHHH Confidence 4566777777 46778888888888888764221 1 12356667777777888899999999988764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+..++ .+ .++.++..++.+|..+....+.. +.....++.+...+.+. ++.++..++ T Consensus 146 -----~~~~~~~l~~~l~~~~------~~~~vr~~a~~~L~~l~~~~~~~---~~~~~~~~~l~~~l~~~-~~~vr~~a~ 210 (398) T 4NEE_G 146 -----AEAFAGEIPKILVAGD------TMDSVKQSAALCLLRLYRTSPDL---VPMGDWTSRVVHLLNDQ-HLGVVTAAT 210 (398) T ss_dssp -----HHHHTTHHHHHHHCSS------SCHHHHHHHHHHHHHHHHHCGGG---SCCSSHHHHHHGGGGCS-CHHHHHHHH T ss_pred -----HHHHHHhHHHHHhcCC------CCHHHHHHHHHHHHHHHHHChhh---ccccchHHHHHHHhcCC-CHHHHHHHH Confidence 112455566666 54 36788999999999987643221 11234567777777665 678888888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..+... T Consensus 211 ~~l~~l~~~ 219 (398) T 4NEE_G 211 SLITTLAQK 219 (398) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHh Confidence 888887764 No 303 >6MQ5_A CLIP-associating protein 1; Microtubule Plus End Binding, STRUCTURAL; HET: MSE; 2.146A {Homo sapiens} Probab=89.98 E-value=0.015 Score=52.93 Aligned_cols=111 Identities=16% Similarity=0.126 Sum_probs=61.3 Template_Neff=11.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQL----IGLKEKGLPQIA-RLLQSGNSDVVRSGASLLSNM 622 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~----llie~giI~~Ll-~LL~s~d~eVr~~AL~aLsnL 622 (747) .++.++..+. +.++.++..++..|..++..... ... ......+++.+. .++.+.++.++..++.++..+ T Consensus 4 ~l~~l~~~l~-~~~~~~r~~a~~~L~~~~~~~~~-----~~~~~~~~~~~~~~~~~l~~~~l~d~~~~vr~~a~~~l~~l 77 (257) T 6MQ5_A 4 RMESCLAQVL-QKDVGKRLQVGQELIDYFSDKQK-----SADLEHDQTMLDKLVDGLATSWVNSSNYKVVLLGMDILSAL 77 (257) T ss_dssp SHHHHHHHHH-CCCHHHHHHHHHHHHHHHHCTTT-----TTTTTTCHHHHHHHHHHCCCCCTTCSSHHHHHHHHHHHHHH T ss_pred hHHHHHHHHh-cCCHHHHHHHHHHHHHHHhcccc-----ccccccCHHHHHHHHHHHHHHHhcCCcHHHHHHHHHHHHHH Confidence 3555666676 46778888888888888764321 010 001234555555 456667778888899988888 Q NP_000290.2 623 SRHP-LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 623 a~~~-e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) +... .........+++.++..+.+ .+..++..++.+|..+.. T Consensus 78 ~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~ 120 (257) T 6MQ5_A 78 VTRLQDRFKAQIGTVLPSLIDRLGD------AKDSVREQDQTLLLKIMD 120 (257) T ss_dssp HHHHGGGGHHHHHHHHHHHHHHTTC------SCHHHHHHHHHHHHHHHH T ss_pred HHHhHHHHHHHHHhHHHHHHHHhcC------CCHHHHHHHHHHHHHHHH Confidence 7651 11000111244444444443 234455555555555543 No 304 >4UQI_B AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ENDOCYTOSIS, PROTEIN TRANSPORT, LIPID BINDING; HET: IHP; 2.79A {RATTUS NORVEGICUS} Probab=89.98 E-value=0.015 Score=60.62 Aligned_cols=109 Identities=11% Similarity=0.011 Sum_probs=67.1 Template_Neff=12.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+....+..........+++.+...+.+.+..++..++.++..+....... T Consensus 160 ~~~~~l~~~l~d~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~L~~l~~~~~~~--- 236 (657) T 4UQI_B 160 GFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDRE--- 236 (657) T ss_pred chHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCChhhhhhhhhcHHHHHHHHhcCCCHHHHHHHHHHHHhhCCCCHHH--- Confidence 34556666666777788888888888887653321111112345566666666666677777888887776432211 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ...+++.+...+. +.++.++..++.++..+.. T Consensus 237 --~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~ 268 (657) T 4UQI_B 237 --AQSICERVTPRLS-HANSAVVLSAVKVLMKFLE 268 (657) T ss_pred --HHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHh Confidence 1234555556665 4566778888888877765 No 305 >4XRI_A Importin Beta; Transport Protein, Nuclear Transport, Transport; HET: GOL, SO4; 2.05A {Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)} Probab=89.95 E-value=0.014 Score=61.52 Aligned_cols=159 Identities=9% Similarity=0.055 Sum_probs=88.2 Template_Neff=13.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQS--GNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s--~d~eVr~~AL~aLsnLa~~ 625 (747) +++.+...+....+..++..++.++..++..... ....+ -..+++.+...+.+ .+..++..++.++..++.. T Consensus 651 ~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~~~vr~~a~~~l~~l~~~ 724 (882) T 4XRI_A 651 FAPFLYNALGNQEEPSLCSMAIGLVSDVTRSLGE-----RSQPY-CDNFMNYLLGNLRSTTLANQFKPAILQCFGDIASA 724 (882) T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHhhh-----ccHhh-HHHHHHHHHHHHcCCCCCHHHHHHHHHHHHHHHHh Confidence 4566666665214566777888888877654221 01111 13466677777766 5677888999999988865 Q NP_000290.2 626 -PLL-HRVMGNQVFPEVTRLLTSHTGN------TSNSEDILSSACYTVRNLMASQPQL-----AKQYFSSSMLNNIINLC 692 (747) Q Consensus 626 -~e~-~~ll~~giI~~Ll~LL~s~s~~------~~~d~eVr~~Al~aLsnLa~~s~e~-----~~~Lve~giL~~Ll~LL 692 (747) +.. ..++ ..+++.+...+...... ......++..++.++..++...... ...+. ..+++.+...+ T Consensus 725 ~~~~~~~~~-~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~-~~i~~~l~~~~ 802 (882) T 4XRI_A 725 IGGHFETYL-TIVAQVLQQAATITAGPDGSYEMIDYVISLREGIMDAWGGIIGAMKTSNKTNVLQPYV-ESIFALLNSIA 802 (882) T ss_pred CCcccHhHH-HHHHHHHHHHhcCCCCCCCCccccccCHHHHHHHHHHHHHHHHhcChhcchhhchhcH-HhHHHHHHHHh Confidence 211 1111 22444444444321000 0003456667777777776532211 11111 23456666666 Q NP_000290.2 693 RSSAS--PKAAEAARLLLSDMWSSK 715 (747) Q Consensus 693 ~s~~d--~eVr~aAL~aLsnL~~~~ 715 (747) .+. + ..++..++.++..++... T Consensus 803 ~~~-~~~~~vr~~a~~~l~~l~~~~ 826 (882) T 4XRI_A 803 NDP-NRSEALMRASMGVIGDLADAY 826 (882) T ss_pred cCC-CCCHHHHHHHHHHHHHHHHHh Confidence 654 4 788889999998887543 No 306 >4NEE_B AP-2 complex subunit sigma, AP-2; clathrin Adaptor AP-2, HIV-1 Nef; 2.8841A {Rattus norvegicus} Probab=89.83 E-value=0.016 Score=56.57 Aligned_cols=141 Identities=15% Similarity=0.147 Sum_probs=94.8 Template_Neff=11.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++.++. +++..++..++.+|..+....+. . ...+++.+...+.+.++.++..++.+|+.+..... T Consensus 77 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~al~~l~~~~~~~~ 145 (398) T 4NEE_B 77 GHMEAVNLLS-SNRYTEKQIGYLFISVLVNSNSE--------L--IRLINNAIKNDLASRNPTFMGLALHCIANVGSREM 145 (398) T ss_pred hHHHHHHHhc-CCCHHHHHHHHHHHHHhcccCHH--------H--HHHHHHHHHHHhcCCCHHHHHHHHHHHHhhCCHHH Confidence 4566777776 46778888888888888764221 1 12356667777777888899999999987764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+..++ .+ .++.++..++.+|..+....+.. +.....++.+...+.+. ++.++..++ T Consensus 146 -----~~~~~~~l~~~l~~~~------~~~~vr~~a~~~L~~l~~~~~~~---~~~~~~~~~l~~~l~~~-~~~vr~~a~ 210 (398) T 4NEE_B 146 -----AEAFAGEIPKILVAGD------TMDSVKQSAALCLLRLYRTSPDL---VPMGDWTSRVVHLLNDQ-HLGVVTAAT 210 (398) T ss_pred -----HHHHHHHHHHHHcCCC------CCHHHHHHHHHHHHHHHHHChhH---hcHhhHHHHHHHHhcCC-CHHHHHHHH Confidence 112455566666 54 36788999999999987643221 11234567777777665 778888888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..+... T Consensus 211 ~~l~~l~~~ 219 (398) T 4NEE_B 211 SLITTLAQK 219 (398) T ss_pred HHHHHHHHh Confidence 888887764 No 307 >6EN4_C Splicing factor 3B subunit 3; Protein complex, splicing modulator, SPLICING; HET: BGZ; 3.08A {Homo sapiens} Probab=89.78 E-value=0.015 Score=61.60 Aligned_cols=153 Identities=8% Similarity=0.015 Sum_probs=85.9 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .+..+...+. +....++..++.++..+...... ...... ....+++.+...+.+. ..++..++.+|..++.... T Consensus 397 ~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~---~~~~~~-~~~~~~~~l~~~l~~~-~~~~~~a~~~l~~l~~~~~ 470 (852) T 6EN4_C 397 IISRIVDDLK-DEAEQYRKMVMETIEKIMGNLGA---ADIDHK-LEEQLIDGILYAFQEQ-TTEDSVMLNGFGTVVNALG 470 (852) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCCh---hhcCHH-HHHHHHHHHHHhcCCC-HHHHHHHHHHHHHHHHcCC Confidence 3445555555 34556677777777777653221 000011 1123445555555433 4677888888888876521 Q NP_000290.2 628 -L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 -~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) . .... ..+++.+...+.+ .++.++..++.++..++..............+++.+...+.+. +..++..++ T Consensus 471 ~~~~~~~-~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v~~~a~ 542 (852) T 6EN4_C 471 KRVKPYL-PQICGTVLWRLNN------KSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEE-YPEVLGSIL 542 (852) T ss_pred hhhHHHH-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhChhhcCHHHHHhHHHHHHHHccCC-CHHHHHHHH Confidence 1 1111 2345556666655 3678888999999988864322111112223566666666655 667788888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .++..++.. T Consensus 543 ~~l~~l~~~ 551 (852) T 6EN4_C 543 GALKAIVNV 551 (852) T ss_pred HHHHHHHHh Confidence 888777654 No 308 >5A1V_E ADP-RIBOSYLATION FACTOR 1, COATOMER SUBUNIT; TRANSPORT PROTEIN, COPI, COATOMER, COATED; 21.0A {SACCHAROMYCES CEREVISIAE} Probab=89.57 E-value=0.018 Score=63.83 Aligned_cols=141 Identities=10% Similarity=0.100 Sum_probs=80.8 Template_Neff=10.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQS-GNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s-~d~eVr~~AL~aLsnLa~~~ 626 (747) .++.|+.++.......++..++.++..++...+. .....+..|...+.+ ..+.++..++++|+.+.... T Consensus 397 ~~~~L~~~L~~~~~~~vr~~a~~~l~~l~~~~~~----------~~~~~l~~L~~~l~~~~~~~~~~~a~~~L~~~~~~~ 466 (874) T 5A1V_E 397 LMNFLFTMLREEGGFEYKRAIVDCIISIIEENSE----------SKETGLSHLCEFIEDCEFTVLATRILHLLGQEGPKT 466 (874) T ss_dssp HHHHHHHHHHHHSSSSHHHHHHHHHHHHTTTTHH----------HHHHHHHHHHTSCSSSSCHHHHHHHHHHHHHHCCSS T ss_pred HHHHHHHHHhhcCCchhHHHHHHHHHHHHHHCHH----------HHHHHHHHHHHHHHhcCCHHHHHHHHHHhcccccCC Confidence 4555666665222233566677777776653221 112345556666553 34566777777777665431 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .. ...+++.+...+.+ .++.++..++.+|..+....+. ....++..|..++.+. +..++..|.. T Consensus 467 ~~----~~~~l~~l~~~l~~------~~~~vr~~al~aL~~l~~~~~~-----~~~~i~~~L~~~l~d~-~~~vR~~A~~ 530 (874) T 5A1V_E 467 NN----PSKYIRFIYNRVVL------EHEEVRAGAVSALAKFGAQNEE-----MLPSILVLLKRCVMDD-DNEVRDRATF 530 (874) T ss_dssp SC----HHHHHHHHHHHHHT------SCHHHHHHHHHHHHHHHHHCGG-----GHHHHHHHHHSTTTSS-SSHHHHHHHH T ss_pred CC----HHHHHHHHHHhhcc------CCHHHHHHHHHHHHHHHhcCHH-----HHHHHHHHHHHHccCC-CHHHHHHHHH Confidence 11 01244555555554 3567888888888888764221 1123455555666555 7788888888 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) ++..+... T Consensus 531 ~l~~l~~~ 538 (874) T 5A1V_E 531 YLNVLEQK 538 (874) T ss_dssp HHHHHHTS T ss_pred HHHHHHHh Confidence 88876654 No 309 >5NZR_G Coatomer subunit alpha, Coatomer subunit; COPI, coatomer, coated vesicles, Transport; 9.2A {Mus musculus} Probab=89.57 E-value=0.018 Score=63.83 Aligned_cols=141 Identities=10% Similarity=0.100 Sum_probs=80.8 Template_Neff=10.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQS-GNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s-~d~eVr~~AL~aLsnLa~~~ 626 (747) .++.|+.++.......++..++.++..++...+. .....+..|...+.+ ..+.++..++++|+.+.... T Consensus 397 ~~~~L~~~L~~~~~~~vr~~a~~~l~~l~~~~~~----------~~~~~l~~L~~~l~~~~~~~~~~~a~~~L~~~~~~~ 466 (874) T 5NZR_G 397 LMNFLFTMLREEGGFEYKRAIVDCIISIIEENSE----------SKETGLSHLCEFIEDCEFTVLATRILHLLGQEGPKT 466 (874) T ss_pred HHHHHHHHHhhcCCchhHHHHHHHHHHHHHHCHH----------HHHHHHHHHHHHHHhcCCHHHHHHHHHHhcccccCC Confidence 4555666665222233566677777776653221 112345556666553 34566777777777665431 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .. ...+++.+...+.+ .++.++..++.+|..+....+. ....++..|..++.+. +..++..|.. T Consensus 467 ~~----~~~~l~~l~~~l~~------~~~~vr~~al~aL~~l~~~~~~-----~~~~i~~~L~~~l~d~-~~~vR~~A~~ 530 (874) T 5NZR_G 467 NN----PSKYIRFIYNRVVL------EHEEVRAGAVSALAKFGAQNEE-----MLPSILVLLKRCVMDD-DNEVRDRATF 530 (874) T ss_pred CC----HHHHHHHHHHhhcc------CCHHHHHHHHHHHHHHHhcCHH-----HHHHHHHHHHHHccCC-CHHHHHHHHH Confidence 11 01244555555554 3567888888888888764221 1123455555666555 7788888888 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) ++..+... T Consensus 531 ~l~~l~~~ 538 (874) T 5NZR_G 531 YLNVLEQK 538 (874) T ss_pred HHHHHHHh Confidence 88876654 No 310 >6OWT_A AP-2 complex subunit alpha, AP-2; AP, HIV, Nef, trafficking, Protein;{Rattus norvegicus} Probab=89.50 E-value=0.018 Score=64.23 Aligned_cols=98 Identities=19% Similarity=0.075 Sum_probs=57.2 Template_Neff=11.000 Q NP_000290.2 250 AVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQN 329 (747) Q Consensus 250 Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~~ 329 (747) ++.++.+.+...+..+...+..+....... ...++..+...+.+.++.++..++.++..+.... .... T Consensus 79 l~~ll~s~~~~~r~~~~~~l~~l~~~~~~~-----~~~ii~~l~~~l~~~~~~vr~~Al~~l~~~~~~~-------~~~~ 146 (939) T 6OWT_A 79 AVNLLSSNRYTEKQIGYLFISVLVNSNSEL-----IRLINNAIKNDLASRNPTFMGLALHCIANVGSRE-------MAEA 146 (939) T ss_pred HHHHhcCCCHHHHHHHHHHHHHHccCChHH-----HHHHHHHHHHHhcCCCHHHHHHHHHHHHHhcCHH-------HHHH Confidence 334455555566666666666655432211 1134455556666667778888888887765321 1123 Q NP_000290.2 330 GIREAVSLL--RRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 330 IL~~Ll~lL--~ss~d~eVr~~AL~aLsnLas~ 360 (747) ++..+...+ . +.++.++..++.++..+... T Consensus 147 l~~~l~~~l~~~-~~~~~vR~~a~~~L~~l~~~ 178 (939) T 6OWT_A 147 FAGEIPKILVAG-DTMDSVKQSAALCLLRLYRT 178 (939) T ss_pred HHHHHHHHHcCC-CCCHHHHHHHHHHHHHHHHH Confidence 444555555 4 45677888888888887763 No 311 >5KC2_B Phosphatidylinositol 3-kinase VPS34 (E.C.2.7.1.137), Serine/threonine-protein; autophagy, phosphatidylinositol 3-kinase (PtdIns3K), endocytosis; 28.0A {Saccharomyces cerevisiae} Probab=89.34 E-value=0.021 Score=68.25 Aligned_cols=151 Identities=13% Similarity=0.081 Sum_probs=101.4 Template_Neff=9.500 Q NP_000290.2 548 AI-RTYLNLMGKS-KKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I-~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) ++ +.|+.++. + .+..++..++..|..+....+. .. ....+++.|...|.+.++.++..++.+|..++.. T Consensus 424 ~~~p~l~~ll~-~~~d~~~R~~al~~L~~~~~~~~~-------~~-~~~~i~p~l~~~l~d~~~~vr~~a~~~l~~l~~~ 494 (1454) T 5KC2_B 424 LFISYLSHSIR-SIVSTATKLKNLELLAVFAQFVSD-------EN-KIDRVVPYFVCCFEDSDQDVQALSLLTLIQVLTS 494 (1454) T ss_pred HhHHHHHHHhc-CCCCHHHHHHHHHHHHHHhhhCCH-------HH-HHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHH Confidence 56 88999998 5 6777888888888887763221 11 2235688888888888999999999999999821 Q NP_000290.2 626 ----PLL-HRVMGNQVFPEVTRLL---TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQY------------------ 679 (747) Q Consensus 626 ----~e~-~~ll~~giI~~Ll~LL---~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~L------------------ 679 (747) +.. ...+..++++.|..++ .+ .+..++..|+.+|..|+.........+ T Consensus 495 ~~~~~~~~~~~~~~~~l~~L~~ll~~~~d------~~~~vR~~a~~~l~~la~~~~~~~~~~~~~~~~~~~~~~~~~i~~ 568 (1454) T 5KC2_B 495 VRKLNQLNENIFVDYLLPRLKRLLISNRQ------NTNYLRIVFANCLSDLAIIINRFQEFTFAQHCNDNSMDNNTEIME 568 (1454) T ss_pred hhcCHHHHHHHHHcCcHHHHHHHHcCCCC------CcHHHHHHHHHHHHHHhcCCCCcceEEhhHHhhhHHHHHHHHHHH Confidence 111 2234456778888888 65 367888999999998875422111111 Q NP_000290.2 680 ----FSSSMLNNIINLCRS----SASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 680 ----ve~giL~~Ll~LL~s----~~d~eVr~aAL~aLsnL~~~ 714 (747) ...++++.|..++.. . ++.++..|+.+|..+... T Consensus 569 ~~~~~~~~~~~~l~~ll~~~l~d~-~~~vr~~a~~~l~~l~~~ 610 (1454) T 5KC2_B 569 SSTKYSAKLIQSVEDLTVSFLTDN-DTYVKMALLQNILPLCKF 610 (1454) T ss_pred HHHHHHcCHHHHHHHHHHhhcCCC-CHHHHHHHHHHHHHHhcC Confidence 123345556555554 4 677777787777777653 No 312 >2P8Q_A Importin beta-1 subunit, Snurportin-1; HEAT repeat, IBB-domain, Importin, Karyopherin; 2.35A {Homo sapiens} SCOP: a.118.1.1 Probab=89.29 E-value=0.018 Score=60.92 Aligned_cols=154 Identities=10% Similarity=0.087 Sum_probs=87.1 Template_Neff=13.100 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.+|..++..... . .... ....+++.+...+.+.++.++..++.++..++.... T Consensus 367 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~---~-~~~~-~~~~i~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 440 (876) T 2P8Q_A 367 VLPFIKEHIK-NPDWRYRDAAVMAFGCILEGPEP---S-QLKP-LVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLP 440 (876) T ss_dssp HHHHHHHHTT-CSSHHHHHHHHHHHHHTSSSSCH---H-HHHH-HHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHHHHCG T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhCCCh---h-hcHH-HHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHHCc Confidence 3555666666 46677888888888888764221 0 0111 123456677777777778899999999999887521 Q NP_000290.2 628 LH---RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK----------QYFS---SSMLNNIINL 691 (747) Q Consensus 628 ~~---~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~----------~Lve---~giL~~Ll~L 691 (747) .. ......+++.+...+.+ ++.++..++.++..++........ ..+. ..++..+... T Consensus 441 ~~~~~~~~~~~~~~~l~~~l~~-------~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~ 513 (876) T 2P8Q_A 441 EAAINDVYLAPLLQCLIEGLSA-------EPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLET 513 (876) T ss_dssp GGTSSTTTHHHHHHHHHHHTTS-------CHHHHHHHHHHHHHHHHHHHHHHTSSSSSSSCSCCTTGGGHHHHHHHHHHH T ss_pred HHhccchhHHHHHHHHHHHccC-------CHHHHHHHHHHHHHHHHHHHHHhccCCCCCCcchhhccHhHHHHHHHHHHH Confidence 10 11112345555555543 356777888888887754221100 0000 1234444444 Q NP_000290.2 692 CRS--SASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 692 L~s--~~d~eVr~aAL~aLsnL~~~ 714 (747) +.. ..+..++..++.++..+... T Consensus 514 l~~~~~~~~~~r~~~~~~l~~l~~~ 538 (876) T 2P8Q_A 514 TDRPDGHQNNLRSSAYESLMEIVKN 538 (876) T ss_dssp TTCTTTTGGGHHHHHHHHHHHHHHS T ss_pred hcCCCCCcchHHHHHHHHHHHHHHh Confidence 431 11456777777777776643 No 313 >2QNA_A Importin subunit beta-1, Snurportin-1; Nuclear transport, import of spliceosomal; HET: SO4; 2.84A {Homo sapiens} Probab=89.10 E-value=0.019 Score=59.41 Aligned_cols=115 Identities=18% Similarity=0.151 Sum_probs=67.9 Template_Neff=13.200 Q NP_000290.2 245 LTIPKAVQYLSSQD--EKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRS--PNQNVQQAAAGALRNLVFRSTT 320 (747) Q Consensus 245 ~iL~~Ll~lL~ssd--~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s--~d~eVr~~AL~aLs~La~~~~~ 320 (747) .+++.+...+.+.+ ..++..++.++..++...+..........+++.+...+.+ .++.++..++.++..++..... T Consensus 3 ~l~~~l~~~l~~~~~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~vr~~a~~~l~~l~~~~~~ 82 (762) T 2QNA_A 3 ELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKA 82 (762) T ss_pred chHHHHHHHhcCCCCCHHHHHHHHHHHHHHHHhCCHhhcHHHHHhHHHHHHHHhcCCCCCHHHHHHHHHHHHHHHhcCCc Confidence 34555666666555 6788888888888775432211111112345666666653 3577888888888888754332 Q NP_000290.2 321 NKL-ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 321 ~~~-~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ... ......+++.+...+. +.++.++..++.++..++.. T Consensus 83 ~~~~~~~~~~i~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~ 122 (762) T 2QNA_A 83 NFDKESERHFIMQVVCEATQ-CPDTRVRVAALQNLVKIMSL 122 (762) T ss_pred cCCcchhHHhHHHHHHHHhC-CCCHHHHHHHHHHHHHHHHh Confidence 111 0111234555555665 45677888888888887763 No 314 >1IBR_B RAN IMPORTIN BETA SUBUNIT; SMALL GTPASE NUCLEAR TRANSPORT; HET: GNP; 2.3A {Homo sapiens} SCOP: a.118.1.1 Probab=89.10 E-value=0.019 Score=55.65 Aligned_cols=154 Identities=11% Similarity=0.066 Sum_probs=94.9 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsnLa 623 (747) .++.|...+. +.+ +.++..++.+|..+...... . .... ....+++.+...+.+.+ ..++..++.++..++ T Consensus 129 ~~~~l~~~l~-~~~~~~~~~~~~l~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~~~vr~~a~~~l~~l~ 202 (462) T 1IBR_B 129 LIPQLVANVT-NPNSTEHMKESTLEAIGYICQDIDP---E-QLQD-KSNEILTAIIQGMRKEEPSNNVKLAATNALLNSL 202 (462) T ss_dssp HHHHHHHHHH-CTTCCHHHHHHHHHHHHHHHHHSCG---G-GTGG-GHHHHHHHHHHHHSTTCCCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHhh-CCCCchHHHHHHHHHHHHHhhcCCH---H-HHHH-HHHHHHHHHHHHHhCCCCCHHHHHHHHHHHHHHH Confidence 5666777776 344 67788888888888764221 0 0001 12456777788887766 889999999999887 Q NP_000290.2 624 RHPLL-H--RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 624 ~~~e~-~--~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) ..... . ......+...+..++.+ .++.++..++.+|..+...............+++.+...+.+. ++.+ T Consensus 203 ~~~~~~~~~~~~~~~~~~~l~~~~~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v 275 (462) T 1IBR_B 203 EFTKANFDKESERHFIMQVVCEATQC------PDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSD-IDEV 275 (462) T ss_dssp TTTHHHHTSHHHHHHHHHHHHHHTTC------SSHHHHHHHHHHHHHHHHHCGGGCTTTTTTTHHHHHHHHHHCS-SHHH T ss_pred HHHHHhCCCHHHHHHHHHHHhHHhcC------CCHHHHHHHHHHHHHHHHHHHHHHHHhccHHHHHHHHHHHhcC-CHHH Confidence 65211 0 11222233334444433 3567888889999888764333222222222366667777665 7788 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..++.. T Consensus 276 ~~~a~~~l~~l~~~ 289 (462) T 1IBR_B 276 ALQGIEFWSNVCDE 289 (462) T ss_dssp HHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH Confidence 88898888888764 No 315 >1QGR_A IMPORTIN BETA SUBUNIT, IMPORTIN ALPHA-2; TRANSPORT RECEPTOR, NUCLEAR IMPORT, HEAT; 2.3A {Homo sapiens} SCOP: a.118.1.1 Probab=88.89 E-value=0.021 Score=60.61 Aligned_cols=154 Identities=10% Similarity=0.084 Sum_probs=87.2 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.+|..++..... . .... .-..+++.+...+.+.++.++..++.++..++.... T Consensus 367 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 440 (876) T 1QGR_A 367 VLPFIKEHIK-NPDWRYRDAAVMAFGCILEGPEP---S-QLKP-LVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLP 440 (876) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHcCCH---H-hcHH-HHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHhCC Confidence 3455556666 36677888888888888764221 0 0111 123456677777777788899999999999887521 Q NP_000290.2 628 L--H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK----------QYFS---SSMLNNIINL 691 (747) Q Consensus 628 ~--~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~----------~Lve---~giL~~Ll~L 691 (747) . . ......+++.+...+.+ ++.++..++.++..++........ ..+. ..++..+... T Consensus 441 ~~~~~~~~~~~~~~~l~~~l~~-------~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~ 513 (876) T 1QGR_A 441 EAAINDVYLAPLLQCLIEGLSA-------EPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLET 513 (876) T ss_pred hhhcCCchHHHHHHHHHHHhcC-------CHHHHHHHHHHHHHHHHHhhhccCCCCCCCCCcchhhhhhHHHHHHHHHHH Confidence 1 0 11112345555555543 356777888888887754221100 0000 1234444444 Q NP_000290.2 692 CRS--SASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 692 L~s--~~d~eVr~aAL~aLsnL~~~ 714 (747) +.. ..+..++..++.++..++.. T Consensus 514 l~~~~~~~~~~r~~~~~~l~~l~~~ 538 (876) T 1QGR_A 514 TDRPDGHQNNLRSSAYESLMEIVKN 538 (876) T ss_pred hcCCCCCCHHHHHHHHHHHHHHHHc Confidence 431 11456777788877777643 No 316 >2DB0_A 253aa long hypothetical protein; HEAT repeats, helical structure, Structural; 2.2A {Pyrococcus horikoshii} Probab=88.88 E-value=0.021 Score=50.55 Aligned_cols=141 Identities=13% Similarity=0.132 Sum_probs=92.6 Template_Neff=12.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..+...... . ....++.+...+.+.+..++..++.++..+..... T Consensus 108 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~~~~~a~~~l~~~~~~~~ 176 (253) T 2DB0_A 108 MIPVLFANYR-IGDEKTKINVSYALEEIAKANPM--------L--MASIVRDFMSMLSSKNREDKLTALNFIEAMGENSF 176 (253) T ss_dssp HHHHHHHHSC-CCSHHHHHHHHHHHHHHHHHCHH--------H--HHHHHHHHHHHTSCSSHHHHHHHHHHHHTCCTTTH T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHCHH--------H--HHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHhhcH Confidence 4566677776 46778888888888887653211 1 13456667777777778888888888887654311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . .....++.+...+.+ .++.++..++.+|..+....+ .....++.+...+.+. ++.++..++.+ T Consensus 177 ~---~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~~~------~~~~~~~~l~~~l~~~-~~~vr~~a~~~ 240 (253) T 2DB0_A 177 K---YVNPFLPRIINLLHD------GDEIVRASAVEALVHLATLND------KLRKVVIKRLEELNDT-SSLVNKTVKEG 240 (253) T ss_dssp H---HHGGGHHHHHGGGGC------SSHHHHHHHHHHHHHHHTSCH------HHHHHHHHHHHHCCCS-CHHHHHHHHHH T ss_pred H---hHHhHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCH------HHHHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 0 011345556666665 367888899999998875322 1123466666667665 67889999999 Q NP_000290.2 708 LSDMWSSK 715 (747) Q Consensus 708 LsnL~~~~ 715 (747) |..+.... T Consensus 241 l~~l~~~~ 248 (253) T 2DB0_A 241 ISRLLLLE 248 (253) T ss_dssp HHHHHHC- T ss_pred HHHHHHHh Confidence 98887644 No 317 >2DB0_B 253aa long hypothetical protein; HEAT repeats, helical structure, Structural; 2.2A {Pyrococcus horikoshii} Probab=88.88 E-value=0.021 Score=50.55 Aligned_cols=141 Identities=13% Similarity=0.132 Sum_probs=93.1 Template_Neff=12.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..+...... . ....++.+...+.+.+..++..++.++..+..... T Consensus 108 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~~~~~a~~~l~~~~~~~~ 176 (253) T 2DB0_B 108 MIPVLFANYR-IGDEKTKINVSYALEEIAKANPM--------L--MASIVRDFMSMLSSKNREDKLTALNFIEAMGENSF 176 (253) T ss_dssp HHHHHTTTCC-CCSHHHHHHHHHHHHHHHHHCHH--------H--HHHHHHHHHGGGGCSSHHHHHHHHHHHTTCCTTTH T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHCHH--------H--HHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHhhcH Confidence 4566677776 46778888888888887653211 1 13456667777777778888888888887654311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . .....++.+...+.+ .++.++..++.+|..+....+ .....++.+...+.+. ++.++..++.+ T Consensus 177 ~---~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~~~------~~~~~~~~l~~~l~~~-~~~vr~~a~~~ 240 (253) T 2DB0_B 177 K---YVNPFLPRIINLLHD------GDEIVRASAVEALVHLATLND------KLRKVVIKRLEELNDT-SSLVNKTVKEG 240 (253) T ss_dssp H---HHGGGHHHHHGGGGC------SCHHHHHHHHHHHHHHHHHCH------HHHHHHHHHHHTCCCS-CHHHHHHHHHH T ss_pred H---hHHhHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCH------HHHHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 0 011345556666665 367888899999998875322 1123466666667665 67889999999 Q NP_000290.2 708 LSDMWSSK 715 (747) Q Consensus 708 LsnL~~~~ 715 (747) |..+.... T Consensus 241 l~~l~~~~ 248 (253) T 2DB0_B 241 ISRLLLLE 248 (253) T ss_dssp HHHHHTTC T ss_pred HHHHHHHh Confidence 98887644 No 318 >4K92_B CLIP-associating protein 1; HEAT-Repeat TOG domain, Regulator of; HET: MSE; 2.005A {Homo sapiens} Probab=88.82 E-value=0.022 Score=52.46 Aligned_cols=148 Identities=16% Similarity=0.091 Sum_probs=93.3 Template_Neff=11.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.+...+. +.+..++..++.+|..++..... .... .-..+++.|+..+.+.+..++..++.+|..++.... T Consensus 90 l~~~l~~~l~-d~~~~v~~~a~~~l~~l~~~~~~-----~~~~-~~~~~l~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 162 (273) T 4K92_B 90 LDGAFKLSAK-DLRSQVVREACITLGHLSSVLGN-----KFDH-GAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTH 162 (273) T ss_dssp THHHHHHHHT-CSCHHHHHHHHHHHHHHHHHHGG-----GGHH-HHHHHHHHHHTTTTCSSHHHHHHHHHHHHHHHHHCC T ss_pred HHHHHHHHHH-cHHHHHHHHHHHHHHHHHHHHHH-----HhHH-HHHHHHHHHHHHCccccHHHHHHHHHHHHHHHHhCC Confidence 4556666666 46778888899988888764221 0111 123466677777777777788888888888775421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . ..+++.+...+.+ .++.++..++.+|..++...........-..+++.+...+.+. +..++..++.+ T Consensus 163 ~-----~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~i~~~l~~~l~d~-~~~vr~~a~~~ 230 (273) T 4K92_B 163 I-----PRLIPVITSNCTS------KSVAVRRRCFEFLDLLLQEWQTHSLERHISVLAETIKKGIHDA-DSEARIEARKC 230 (273) T ss_dssp C-----TTHHHHHHGGGGC------SCHHHHHHHHHHHHHHHHHSCHHHHTTCHHHHHHHHHHHHTCS-SHHHHHHHHHH T ss_pred C-----chHHHHHHHHcCC------CCHHHHHHHHHHHHHHHHHcCchhHHHHHHHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 1 1234455555554 3577888888888888764322100011123566666777666 78899999999 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) +..+... T Consensus 231 l~~l~~~ 237 (273) T 4K92_B 231 YWGFHSH 237 (273) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 8887754 No 319 >6MQ7_B CLIP-associating protein 1; microtubule binding protein, STRUCTURAL PROTEIN; 1.78A {Homo sapiens} Probab=88.82 E-value=0.022 Score=52.46 Aligned_cols=148 Identities=16% Similarity=0.091 Sum_probs=93.3 Template_Neff=11.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.+...+. +.+..++..++.+|..++..... .... .-..+++.|+..+.+.+..++..++.+|..++.... T Consensus 90 l~~~l~~~l~-d~~~~v~~~a~~~l~~l~~~~~~-----~~~~-~~~~~l~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 162 (273) T 6MQ7_B 90 LDGAFKLSAK-DLRSQVVREACITLGHLSSVLGN-----KFDH-GAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTH 162 (273) T ss_dssp THHHHHHHHT-CSSHHHHHHHHHHHHHHHHHHGG-----GGHH-HHHHHHHHHHTTTTCSSHHHHHHHHHHHHHHHHHCC T ss_pred HHHHHHHHHH-cHHHHHHHHHHHHHHHHHHHHHH-----HhHH-HHHHHHHHHHHHCccccHHHHHHHHHHHHHHHHhCC Confidence 4556666666 46778888899988888764221 0111 123466677777777777788888888888775421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . ..+++.+...+.+ .++.++..++.+|..++...........-..+++.+...+.+. +..++..++.+ T Consensus 163 ~-----~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~i~~~l~~~l~d~-~~~vr~~a~~~ 230 (273) T 6MQ7_B 163 I-----PRLIPVITSNCTS------KSVAVRRRCFEFLDLLLQEWQTHSLERHISVLAETIKKGIHDA-DSEARIEARKC 230 (273) T ss_dssp C-----GGGHHHHHHGGGC------SCHHHHHHHHHHHHHHHHHSCGGGTTTCHHHHHHHHHHHHTCS-SHHHHHHHHHH T ss_pred C-----chHHHHHHHHcCC------CCHHHHHHHHHHHHHHHHHcCchhHHHHHHHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 1 1234455555554 3577888888888888764322100011123566666777666 78899999999 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) +..+... T Consensus 231 l~~l~~~ 237 (273) T 6MQ7_B 231 YWGFHSH 237 (273) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 8887754 No 320 >1GCJ_B IMPORTIN-BETA; HEAT REPEAT MOTIF, NUCLEAR PORE-TARGETING; HET: MSE; 2.6A {Mus musculus} SCOP: a.118.1.1 Probab=88.73 E-value=0.022 Score=55.37 Aligned_cols=154 Identities=12% Similarity=0.095 Sum_probs=94.5 Template_Neff=12.800 Q NP_000290.2 548 AIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsnLa 623 (747) .++.|+..+. +.+ +.++..++.+|..+...... .........+++.+...+.+.+ +.++..++.++..+. T Consensus 135 ~~~~l~~~l~-~~~~~~~~~~~~l~~l~~l~~~~~~-----~~~~~~~~~~~~~l~~~l~~~~~~~~vr~~a~~~l~~~~ 208 (460) T 1GCJ_B 135 LIPQLVANVT-NPNSTEHMKESTLEAIGYICQDIDP-----EQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSL 208 (460) T ss_dssp HHHHHHHHHH-CTTCCHHHHHHHHHHHHHHHHHSCH-----HHHGGGHHHHHHHHHHHHCTTCSCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHhh-CCCCcHHHHHHHHHHHHHHhhhCCH-----HHhHHHHHHHHHHHHHHHhCCCCCHHHHHHHHHHHHHHH Confidence 4566777776 344 67788888888888764221 0000112356777777787665 889999999999887 Q NP_000290.2 624 RHPLL--H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 624 ~~~e~--~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) ..... . ......+...+..++.+ .+..++..++.+|..+....+......+...+++.+..++.+. ++.+ T Consensus 209 ~~~~~~~~~~~~~~~~~~~l~~~~~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v 281 (460) T 1GCJ_B 209 EFTKANFDKESERHFIMQVVCEATQC------PDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSD-IDEV 281 (460) T ss_dssp TTCHHHHTSHHHHHHHHHHHHHHTTC------SSHHHHHHHHHHHHHHHTTCGGGGGGTCCCCCHHHHHHHHTCS-SHHH T ss_pred HHHHHhCCCHHHHHHHHHHHHHHhCC------CCHHHHHHHHHHHHHHHHHHHHHHHHhccHHHHHHHHHHhhCC-CHHH Confidence 65111 1 11112233344444443 3567888889999888765333222222222366677777665 7788 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..++.. T Consensus 282 ~~~a~~~l~~l~~~ 295 (460) T 1GCJ_B 282 ALQGIEFWSNVCDE 295 (460) T ss_dssp HHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH Confidence 88899988888764 No 321 >1F59_B IMPORTIN BETA-1/FXFG NUCLEOPORIN; Protein-protein complex, TRANSPORT PROTEIN RECEPTOR; 2.8A {Homo sapiens} SCOP: a.118.1.1 Probab=88.68 E-value=0.022 Score=54.84 Aligned_cols=154 Identities=11% Similarity=0.067 Sum_probs=94.0 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsnLa 623 (747) .++.+...+. +.+ +.++..++.+|..+...... . .... ....+++.+..++.+.+ ..++..++.++..++ T Consensus 129 ~~~~l~~~l~-~~~~~~~~~~~~l~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~~~vr~~a~~~l~~l~ 202 (442) T 1F59_B 129 LIPQLVANVT-NPNSTEHMKESTLEAIGYICQDIDP---E-QLQD-KSNEILTAIIQGMRKEEPSNNVKLAATNALLNSL 202 (442) T ss_dssp HHHHHHHHHH-CTTCCHHHHHHHHHHHHHHHHHSCG---G-GGGG-GHHHHHHHHHHTTSTTCCCHHHHHHHHHHHHHHS T ss_pred HHHHHHHHhh-CCCCcHHHHHHHHHHHHHHHhhCCH---H-HhHH-HHHHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHH Confidence 5666777776 344 67788888888887754221 0 0001 12456777777777766 889999999999987 Q NP_000290.2 624 RHPLL--H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 624 ~~~e~--~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) ..... . ......+...+..++.+ .+..++..++.+|..++...+..........+++.+..++.+. ++.+ T Consensus 203 ~~~~~~~~~~~~~~~~~~~l~~~~~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~v 275 (442) T 1F59_B 203 EFTKANFDKESERHFIMQVVCEATQC------PDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSD-IDEV 275 (442) T ss_dssp TTCHHHHHSHHHHHHHHHHHHHHTTC------SSHHHHHHHHHHHHHHHHHTGGGGGGTCCCCCHHHHHHHHHSS-CHHH T ss_pred HHHHHcCCCHHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHHHHHHHHhccHHHHHHHHHHhcCC-cHHH Confidence 65211 1 01112233333333333 3567888889999888765333322222222356666777655 7788 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..++.. T Consensus 276 ~~~a~~~l~~l~~~ 289 (442) T 1F59_B 276 ALQGIEFWSNVCDE 289 (442) T ss_dssp HHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhhH Confidence 88899988888764 No 322 >1UKL_A Importin beta-1 subunit/Sterol regulatory element; Transcription factor, Nuclear transport factor; HET: MSE; 3.0A {Mus musculus} SCOP: a.118.1.1 Probab=88.63 E-value=0.022 Score=60.17 Aligned_cols=113 Identities=10% Similarity=0.112 Sum_probs=64.3 Template_Neff=13.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTN-KLE 324 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~-~~~ 324 (747) +++.+...+.+.++.++..++.++..+...............+++.+...+.+.+..++..++.++..++...... ... T Consensus 367 ~~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~ 446 (876) T 1UKL_A 367 VLPFIKEHIKNPDWRYRDAAVMAFGSILEGPEPNQLKPLVIQAMPTLIELMKDPSVVVRDTTAWTVGRICELLPEAAIND 446 (876) T ss_dssp HHHHHHHHSSCSSHHHHHHHHHHHHTTSSSSCHHHHHHHHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHHHHCHHHHSCT T ss_pred HHHHHHHHccCCCHHHHHHHHHHHHHHHhCCChhhhHHHHHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHHChHHhcCc Confidence 3344444455566778888888888876543211111112345566666666667788888888888887543321 001 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) .....+++.+...+. . ++.++..++.++..++.. T Consensus 447 ~~~~~~~~~l~~~l~-~-~~~~~~~~~~~l~~l~~~ 480 (876) T 1UKL_A 447 VYLAPLLQCLIEGLS-A-EPRVASNVCWAFSSLAEA 480 (876) T ss_dssp TTHHHHHHHHHHHTT-S-CHHHHHHHHHHHHHHHHH T ss_pred cchHHHHHHHHHHhc-C-ChhHHHHHHHHHHHHHHH Confidence 111234555555554 3 456677777777776653 No 323 >1U6G_C Cullin homolog 1, RING-box protein; cullin repeat, heat repeat, ring; 3.1A {Homo sapiens} SCOP: a.118.1.2 Probab=88.22 E-value=0.025 Score=62.86 Aligned_cols=146 Identities=12% Similarity=0.093 Sum_probs=89.7 Template_Neff=12.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+. . ++.++..++.++..+....+. . .... .-..+++.+...+.+.++.++..++.+|+.+..... T Consensus 891 ~~~~l~~~l~-~-~~~~r~~~~~~l~~i~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 963 (1230) T 1U6G_C 891 YLPFVLQEIT-S-QPKRQYLLLHSLKEIISSASV---V-GLKP-YVENIWALLLKHCECAEEGTRNVVAECLGKLTLIDP 963 (1230) T ss_dssp HHHHHHHHHH-S-CGGGHHHHHHHHHHHHHSSCS---T-TTHH-HHHHHHHHHTTCCCCSSTTHHHHHHHHHHHHHHSSG T ss_pred HHHHHHHHHc-c-CchHHHHHHHHHHHHHhcccc---c-ccHH-hHHHHHHHHHHHcCCCChhHHHHHHHHHHHHHccCH Confidence 4555555554 2 455666777777777653221 0 0001 113466677777777788899999999988876421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...++.+...+.+ .+..++..++.+|..+....+........ ..++.++..+.+. ++.++..++.+ T Consensus 964 ------~~~~~~l~~~l~~------~~~~~r~~~~~~l~~~~~~~~~~~~~~~~-~~~~~l~~~l~d~-~~~vr~~a~~~ 1029 (1230) T 1U6G_C 964 ------ETLLPRLKGYLIS------GSSYARSSVVTAVKFTISDHPQPIDPLLK-NCIGDFLKTLEDP-DLNVRRVALVT 1029 (1230) T ss_dssp ------GGTHHHHTTTSSS------SCHHHHHHHHHHTGGGCCSSCCTHHHHHH-HHSTTTHHHHSSS-STHHHHHHHHH T ss_pred ------HhHHHHHHHHhhC------CCHHHHHHHHHHHHHHHcCCCCCccHHHH-HHHHHHHHHcCCC-CHHHHHHHHHH Confidence 1234555666654 25667788888888877643221111222 4567777777766 77888888888 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) +..+... T Consensus 1030 l~~l~~~ 1036 (1230) T 1U6G_C 1030 FNSAAHN 1036 (1230) T ss_dssp HHHHHHH T ss_pred HHHHHhc Confidence 8888754 No 324 >4MFU_A Beta-catenin-like protein 1; ARM repeats, GENE REGULATION; 2.744A {Homo sapiens} Probab=88.09 E-value=0.031 Score=59.08 Aligned_cols=135 Identities=14% Similarity=0.062 Sum_probs=91.1 Template_Neff=8.700 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDE---------SAKQQVYQLGGICKLVDLLRS------PNQNVQQAAAGA 310 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~---------~~~~~li~~~IL~~Ll~lL~s------~d~eVr~~AL~a 310 (747) +++.|+.++.+.+..+...++.+|..++.... .....+...++++.++..+.. .+......++.+ T Consensus 69 ~i~~Lv~LL~~~n~~i~~~a~~~L~~Lt~~~~~~~~~~~~~~~~~~l~~~g~l~~Lv~~L~~~~e~~~~d~~~~~~al~~ 148 (490) T 4MFU_A 69 AVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDALVDGQVVALLVQNLERLDESVKEEADGVHNTLAI 148 (490) T ss_dssp HHHHHHHHTSCSSHHHHHHHHHHHHHHHHGGGSSCCCHHHHHHHHHHHHTTHHHHHHHHHHHCCTTCHHHHHHHHHHHHH T ss_pred hHHHHHHHhCCCCHHHHHHHHHHHHHHcCcccccCChhhHHHHHHHHHhCCHHHHHHHHHHhccccccchHHHHHHHHHH Confidence 45566677776667778888888888876432 122333445677777777764 456677888899 Q NP_000290.2 311 LRNLVFRSTTNKLETRRQNGIREAVSLLRRTG--NAEIQKQLTGLLWNLSST-DELKEELIA-DALPVLADRVII 381 (747) Q Consensus 311 Ls~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~--d~eVr~~AL~aLsnLas~-~~~~~~Lve-giLe~Lv~LL~~ 381 (747) |.+++...+.....+...++++.|+..+. .. ...++..+..+|..++.. ......+.. ++++.|+.+|.. T Consensus 149 L~nL~~~~~~~~~~i~~~~~l~~Ll~~L~-~~~~~~~~k~~a~~~L~~L~~~~~~~~~~l~~~g~i~~Ll~lL~~ 222 (490) T 4MFU_A 149 VENMAEFRPEMCTEGAQQGLLQWLLKRLK-AKMPFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSV 222 (490) T ss_dssp HHHHHHHSTTHHHHHCCCCCHHHHHHHHH-CCSCCCHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHHT T ss_pred HHHHhccCHHHHHHHHHCCHHHHHHHHHH-cCCCCHHHHHHHHHHHHHHHcCCHHHHHHHHhCchHHHHHHHHHh Confidence 99888654333333444567888888886 33 467788899999999875 333444444 788888888863 No 325 >6CRI_I Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=87.58 E-value=0.03 Score=55.48 Aligned_cols=141 Identities=14% Similarity=0.110 Sum_probs=94.1 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+. +.+..++..++.++..+....+. . ...+++.+...+.+.++.++..++.++..+..... T Consensus 37 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 105 (570) T 6CRI_I 37 LFPDVVNCMQ-TDNLELKKLVYLYLMNYAKSQPD--------M--AIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKI 105 (570) T ss_dssp GHHHHHHTCS-CSCHHHHHHHHHHHHHTTTTSTT--------G--GGTTHHHHHHHTSSSCHHHHHHHHHHHHHCCCTTT T ss_pred hHHHHHHhcc-CCCHHHHHHHHHHHHHHHccCHh--------H--HHHHHHHHHHHcCCCCHHHHHHHHHHHccCChhHH Confidence 4555666676 46677888888888887754221 1 12345666777777788889999998888764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...+++.+...+.+ .++.++..++.+|..+....+... .....++.+...+.+. ++.++..++.+ T Consensus 106 -----~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~~~~~~---~~~~~~~~l~~~l~~~-~~~vr~~a~~~ 170 (570) T 6CRI_I 106 -----TEYLCEPLRKCLKD------EDPYVRKTAAVCVAKLHDINAQLV---EDQGFLDTLKDLISDS-NPMVVANAVAA 170 (570) T ss_dssp -----TTTSHHHHHHHHTC------SSHHHHHHHHHHHHHHHHHCHHHH---HHHTHHHHHHHHHTSS-SHHHHHHHHHH T ss_pred -----HHHHHHHHHHhcCC------CCHHHHHHHHHHHHHHHHhChhhh---hccchHHHHHHHhcCC-CHHHHHHHHHH Confidence 12345556666665 367888999999998876433221 1134567777777766 77888889998 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) |..+... T Consensus 171 l~~~~~~ 177 (570) T 6CRI_I 171 LSEIAES 177 (570) T ss_dssp HHHHHHH T ss_pred HHHHHhh Confidence 8888765 No 326 >3QML_D 78 kDa glucose-regulated protein homolog; Armadillo like repeats, CHAPERONE-PROTEIN TRANSPORT; HET: PO4; 2.31A {Saccharomyces cerevisiae} Probab=87.49 E-value=0.038 Score=55.35 Aligned_cols=165 Identities=6% Similarity=-0.069 Sum_probs=100.7 Template_Neff=7.900 Q NP_000290.2 534 ETNPKGSGWLYHSDAIRTYLNLMGKS-KKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEK--GLPQIA---RLLQ-- 605 (747) Q Consensus 534 ~~ni~~~~~lve~G~I~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~g--iI~~Ll---~LL~-- 605 (747) .+++.....+++.| ++.|+.++... ....++..|+++|+..+.+++. ....+.+.+ +++.|+ ..|. T Consensus 56 ~hdid~a~~~~~~g-~~~L~~~l~~~~~~~~ir~~Aa~iigsa~qNNP~-----aq~~~~~~~~~~l~~Ll~~~~~L~~~ 129 (315) T 3QML_D 56 AHDYKHGYKIITHE-FALLANLSLNENLPLTLRELSTRVITSCLRNNPP-----VVEFINESFPNFKSKIMAALSNLNDS 129 (315) T ss_dssp HTSHHHHHHHHHHH-HHHHHHHHHCTTSCHHHHHHHHHHHHHHHTTCTT-----HHHHHHHHCTTHHHHHHHHHHHHHCC T ss_pred HccHHHHHHHHHch-HHHHHHHHhCCCCCHHHHHHHHHHHHHHHhhCHH-----HHHHHHHHCccHHHHHHHHHHhhccC Confidence 34556666677888 88888888721 5678999999999999988764 344445555 677777 4443 Q NP_000290.2 606 --SGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA------ 676 (747) Q Consensus 606 --s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~------ 676 (747) ..++.++..++.+|+.|+.+... ..+ ++..|..++... ..+..++..++.++..+........ T Consensus 130 ~~~~~~~v~~k~L~aLS~Lir~~~~~~~F----G~~~L~~~~~~~----~~~~~~~~K~l~ll~dl~~~~~~~~~~~~~~ 201 (315) T 3QML_D 130 NHRSSNILIKRYLSILNELPVTSEDLPIY----STVVLQNVYERN----NKDKQLQIKVLELISKILKADMYENDDTNLI 201 (315) T ss_dssp ---CTHHHHHHHHHHHHHSCCCGGGGGGS----CHHHHHHHHHTT----TTCHHHHHHHHHHHHHHHTTTC------CHH T ss_pred CCcCCHHHHHHHHHHHHhhcCCCccHhhh----cHHHHHHHHHhC----CCCHHHHHHHHHHHHHHHHhccccCCCcchH Confidence 35677888999999999987322 222 456666666431 0135677788888888775432211 Q NP_000290.2 677 --------KQYFSSSMLNNIINLCRSS-ASPKAAEAARLLLSDMW 712 (747) Q Consensus 677 --------~~Lve~giL~~Ll~LL~s~-~d~eVr~aAL~aLsnL~ 712 (747) ......+.+..+...+... .+....+.++.+|..|. T Consensus 202 ~~~~~~~~~~~~~~~~c~~l~~~L~~~~~d~~~~ek~l~~L~~L~ 246 (315) T 3QML_D 202 LFKRNAENWSSNLQEWANEFQEMVQNKSIDELHTRTFFDTLYNLK 246 (315) T ss_dssp HHHHHHHTTCSCCHHHHHHHHHHTTCTTSCHHHHHHHHHHHHHHH T ss_pred HhHhhccccchhHHHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHH Confidence 1111133445555555421 13455566666666554 No 327 >5IFE_C Splicing factor 3B subunit 5; pre-mRNA splicing, U2 snRNP, essential; 3.1A {Homo sapiens} Probab=87.43 E-value=0.036 Score=65.15 Aligned_cols=154 Identities=8% Similarity=0.029 Sum_probs=84.9 Template_Neff=9.800 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .++..++..+. +.+..++..++.+|..++..... .. .... ....+++.+...+... ...+..++.+|..++... T Consensus 848 ~il~~l~~~l~-d~~~~~r~~a~~~L~~l~~~~~~--~~-~~~~-~~~~li~~ll~~l~~~-~~~r~~al~~L~~l~~~~ 921 (1304) T 5IFE_C 848 EIISRIVDDLK-DEAEQYRKMVMETIEKIMGNLGA--AD-IDHK-LEEQLIDGILYAFQEQ-TTEDSVMLNGFGTVVNAL 921 (1304) T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhcCh--hh-hHHH-HHHHHHHHHHHHhcCC-HHHHHHHHHHHHHHHHhC Confidence 34556666666 35556777788888777653211 00 0001 1123444455444432 356677788887777652 Q NP_000290.2 627 L-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 627 e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . . ..++ ..++..+...+.+ .+..++..++.+|..++..............++..|...+.+. ++.++..+ T Consensus 922 ~~~~~~~l-~~l~~~L~~~L~~------~~~~vR~~A~~~L~~l~~~~~~~~~~~~~~~l~~~L~~~L~d~-~~~vr~~a 993 (1304) T 5IFE_C 922 GKRVKPYL-PQICGTVLWRLNN------KSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEE-YPEVLGSI 993 (1304) T ss_pred HHHhHHHH-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhccCcCHHHHHHHHHHHHHHHhCCC-CHHHHHHH Confidence 1 1 1111 2355556666655 3678888999999998764222111111123456666666654 56777778 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.+|..++.. T Consensus 994 l~aL~~l~~~ 1003 (1304) T 5IFE_C 994 LGALKAIVNV 1003 (1304) T ss_pred HHHHHHHHHh Confidence 7777776644 No 328 >6AHD_1 Pre-mRNA-processing-splicing factor 8, Thioredoxin-like protein; Spliceosome, SPLICING; HET: IHP, GTP; 3.8A {Homo sapiens} Probab=87.43 E-value=0.036 Score=65.15 Aligned_cols=154 Identities=8% Similarity=0.029 Sum_probs=84.9 Template_Neff=9.800 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .++..++..+. +.+..++..++.+|..++..... .. .... ....+++.+...+... ...+..++.+|..++... T Consensus 848 ~il~~l~~~l~-d~~~~~r~~a~~~L~~l~~~~~~--~~-~~~~-~~~~li~~ll~~l~~~-~~~r~~al~~L~~l~~~~ 921 (1304) T 6AHD_1 848 EIISRIVDDLK-DEAEQYRKMVMETIEKIMGNLGA--AD-IDHK-LEEQLIDGILYAFQEQ-TTEDSVMLNGFGTVVNAL 921 (1304) T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhcCh--hh-hHHH-HHHHHHHHHHHHhcCC-HHHHHHHHHHHHHHHHhC Confidence 34556666666 35556777788888777653211 00 0001 1123444455444432 356677788887777652 Q NP_000290.2 627 L-L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 627 e-~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . . ..++ ..++..+...+.+ .+..++..++.+|..++..............++..|...+.+. ++.++..+ T Consensus 922 ~~~~~~~l-~~l~~~L~~~L~~------~~~~vR~~A~~~L~~l~~~~~~~~~~~~~~~l~~~L~~~L~d~-~~~vr~~a 993 (1304) T 6AHD_1 922 GKRVKPYL-PQICGTVLWRLNN------KSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEE-YPEVLGSI 993 (1304) T ss_pred HHHhHHHH-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhccCcCHHHHHHHHHHHHHHHhCCC-CHHHHHHH Confidence 1 1 1111 2355556666655 3678888999999998764222111111123456666666654 56777778 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.+|..++.. T Consensus 994 l~aL~~l~~~ 1003 (1304) T 6AHD_1 994 LGALKAIVNV 1003 (1304) T ss_pred HHHHHHHHHh Confidence 7777776644 No 329 >5MU7_A Coatomer subunit beta, Coatomer subunit; coatomer, COPI, beta COP, delta; 2.57A {Chaetomium thermophilum var. thermophilum DSM 1495} Probab=87.43 E-value=0.031 Score=52.40 Aligned_cols=141 Identities=16% Similarity=0.154 Sum_probs=92.9 Template_Neff=12.800 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL 628 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~ 628 (747) ++.++..+. +.++.++..++.+|..+....+. .....++.+...+.+.+..++..++.+|..+...... T Consensus 190 ~~~l~~~l~-~~~~~~~~~a~~~l~~~~~~~~~----------~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~~ 258 (373) T 5MU7_A 190 LGTVFEGIP-NAEELLQLVEIEFIRKDALHNPQ----------NKPRYLRLIFDLLEANTSTVVYEAASSLTALTNNPVA 258 (373) T ss_dssp HHHTGGGGG-GSCHHHHHHHHHHHHHHHHHCGG----------GHHHHHHHHHHHTTCSSHHHHHHHHHHHHHHCCCHHH T ss_pred HHHHHhcCC-ChhHHHHHHHHHHHHHHhccCcc----------cHHHHHHHHHHHHhcCCHHHHHHHHHHHHHcCCCHHH Confidence 455566666 35667777888888887653221 1234566777777777788888888888887743211 Q NP_000290.2 629 HRVMGNQVFPEVTRLLT-SHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 629 ~~ll~~giI~~Ll~LL~-s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . ..+++.+...+. + .++.++..++.+|..+....+.. + ...++.+...+.+. ++.++..++.+ T Consensus 259 ---~-~~~~~~l~~~l~~~------~~~~vr~~a~~~l~~l~~~~~~~----~-~~~~~~l~~~l~~~-~~~vr~~a~~~ 322 (373) T 5MU7_A 259 ---V-KAAAGKFIELAIKE------ADNNVKLIVLDRVDQLRQKNEGI----L-DDLIMEILRVLSSP-DIDVRRKALEI 322 (373) T ss_dssp ---H-HHHHHHHHHHHHHC------CCHHHHHHHHHHHHHHHHHTTTT----T-GGGHHHHHHGGGSS-CHHHHHHHHHH T ss_pred ---H-HHHHHHHHHHHhhC------CChhHHHHHHHHHHHHHHhCHHH----H-HHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 1 134556666665 4 36788889999999887643211 1 13566677777665 77889999999 Q NP_000290.2 708 LSDMWSSKE 716 (747) Q Consensus 708 LsnL~~~~~ 716 (747) |..+..... T Consensus 323 l~~~~~~~~ 331 (373) T 5MU7_A 323 ALEMVSSKN 331 (373) T ss_dssp HHTTCCTTT T ss_pred HHHHhcCCC Confidence 998876544 No 330 >5VE8_B Kap123, Histone H3; Bidding yeast karyopherin, 23 HEAT; HET: MSE; 2.7A {Kluyveromyces lactis} Probab=87.41 E-value=0.031 Score=61.14 Aligned_cols=154 Identities=11% Similarity=0.104 Sum_probs=81.3 Template_Neff=12.900 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL-QSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL-~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) ++.+...+. ..++.++..++.++..++..... ... ....+++.++..+ .+.++.++..++.++..++.. + T Consensus 868 ~~~l~~~~~-~~~~~~r~~~~~~l~~l~~~~~~------~~~-~~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~~~~~ 939 (1116) T 5VE8_B 868 KPVILQLCQ-SKSKNKRSFAVGALSEIALGMRD------ENP-FIQELLEALIISLTNDKSLEVRCNASYGVGLLIEYSS 939 (1116) T ss_dssp HHHHHHHTT-CSCHHHHHHHHHHHHHHHHHHGG------GCT-THHHHHHHHHHHHHHCSCHHHHHHHHHHHHHHHHHCC T ss_pred HHHHHHHcC-CCCHHHHHHHHHHHHHHHHhCCC------Cch-hHHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHHhCC Confidence 333444443 24556677777777777653221 111 1134555555553 345678889999999888865 2 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGN----------TSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSS 695 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~----------~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~ 695 (747) .. ...+ ..+++.|...+...... ......++..++.+|+.+....+... ....+++.++..+... T Consensus 940 ~~~~~~~-~~il~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~---~~~~~l~~~~~~l~~~ 1015 (1116) T 5VE8_B 940 FDVSAIY-SPVLKSLYEILSVADEKNLATEDDEATKEIVDRTFSNVCGCVARMILKHQNLV---PLEHTIPALLSHLPFN 1015 (1116) T ss_dssp SCCHHHH-HHHHHHHHHHHHHHHHHC-----CHHHHHHHHHHHHHHHHHHHHHHHHCGGGS---CHHHHHHHHHTTCSCS T ss_pred cchhhhH-HHHHHHHHHHhcchhHhccCCCCchhhHHHHHHHHHHHHHHHHHHHHHCcccC---CHHHHHHHHHhcCCCC Confidence 11 1111 23555566555431000 00245667788888888876533211 1123455555555322 Q NP_000290.2 696 ASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 696 ~d~eVr~aAL~aLsnL~~~ 714 (747) .+...+..++.+|..+... T Consensus 1016 ~~~~~~~~~~~~l~~l~~~ 1034 (1116) T 5VE8_B 1016 TAFEEYDPIFKLFLKLFQE 1034 (1116) T ss_dssp SCGGGHHHHHHHHHHHHHT T ss_pred CchhhhHHHHHHHHHHHHh Confidence 1455666677777766543 No 331 >2IX8_A ELONGATION FACTOR 3A; NUCLEOTIDE-BINDING, PROTEIN BIOSYNTHESIS, PHOSPHORYLATION, ELONGATION; 6.0A {SACCHAROMYCES CEREVISIAE} Probab=87.28 E-value=0.034 Score=61.28 Aligned_cols=150 Identities=9% Similarity=0.007 Sum_probs=99.4 Template_Neff=11.800 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.|...+. +.++.++..++.+|..+...... .... ....+++.|...+.+.++.++..|+.+|..++... T Consensus 48 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~ 120 (976) T 2IX8_A 48 HFFGELAKGIK-DKKTAANAMQAVAHIANQSNLSP-----SVEP-YIVQLVPAICTNAGNKDKEIQSVASETLISIVNAV 120 (976) T ss_dssp HHHHHHHHHHT-STTTHHHHHHHHHHHSCTTTCCT-----TTHH-HHHTTHHHHHHHTTCSSHHHHHHHHHHHHHHHHHS T ss_pred HHHHHHHHHcc-CHHHHHHHHHHHHHHHHHhccCc-----ccHH-HHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHhc Confidence 45677777777 46677888888888888753221 0111 12356777777888888889999999999887652 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLL-TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL-~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .... ...+++.|...+ .+ .++.++..++.+|..++...+....... ..+++.+..++.+. +..++..++ T Consensus 121 ~~~~--~~~~l~~l~~~l~~~------~~~~vr~~al~~L~~l~~~~~~~~~~~~-~~~~~~l~~~l~d~-~~~vr~~a~ 190 (976) T 2IX8_A 121 NPVA--IKALLPHLTNAIVET------NKWQEKIAILAAFSAMVDAAKDQVALRM-PELIPVLSETMWDT-KKEVKAAAT 190 (976) T ss_dssp CGGG--HHHHHHHHHHHHHHC------CCHHHHHHHHHHHHHHHHHSHHHHHHHH-HHHHHHHHHHTTCS-CHHHHHHHH T ss_pred CHHH--HHHHHHHHHHHHhhc------CCHHHHHHHHHHHHHHHHHHHHhHHhhc-hhHHHHHHHhhcCC-CHHHHHHHH Confidence 1111 123556666666 33 3567888899999988864322211111 24677777777766 788899999 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .+|..+.. T Consensus 191 ~~l~~l~~ 198 (976) T 2IX8_A 191 AAMTKATE 198 (976) T ss_dssp HHHHHHST T ss_pred HHHHHHHH Confidence 99888876 No 332 >3WOY_A CLIP-associating protein 2; HEAT Repeat, Microtubule binding, Tubulin; 2.1A {Homo sapiens} Probab=87.26 E-value=0.034 Score=50.12 Aligned_cols=147 Identities=14% Similarity=0.116 Sum_probs=92.3 Template_Neff=11.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.+..++..++.++..++..... ....+ -..+++.+...+.+....++..+..++..++.... T Consensus 78 l~~~l~~~l~-d~~~~v~~~a~~~l~~l~~~~~~-----~~~~~-~~~l~~~l~~~l~~~~~~vr~~a~~~l~~i~~~~~ 150 (251) T 3WOY_A 78 LDGALKLSAK-DLRSQVVREACITVAHLSTVLGN-----KFDHG-AEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTH 150 (251) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHHCc-----ccHHH-HHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHcCC Confidence 4555666666 46678888899999888764321 01111 13456667777766677788888888888875421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL-AKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~-~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) . ..+++.+...+.+ .++.++..++.++..++...... .... -..+++.+...+.+. +..++..++. T Consensus 151 ~-----~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~-~~~i~~~l~~~l~d~-~~~vr~~a~~ 217 (251) T 3WOY_A 151 V-----PRLIPLITSNCTS------KSVPVRRRSFEFLDLLLQEWQTHSLERH-AAVLVETIKKGIHDA-DAEARVEARK 217 (251) T ss_pred H-----hhHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHHCHHhhHHh-HHHHHHHHHHHhcCC-CHHHHHHHHH Confidence 1 1244455555554 35677888888888887542211 1111 123566677777766 7889999999 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) ++..+... T Consensus 218 ~l~~l~~~ 225 (251) T 3WOY_A 218 TYMGLRNH 225 (251) T ss_pred HHHHHHHH Confidence 88887754 No 333 >5DN7_A Protein FAM179B; TOG domain, STRUCTURAL PROTEIN; 2.2A {Mus musculus} Probab=87.22 E-value=0.035 Score=51.97 Aligned_cols=146 Identities=10% Similarity=0.046 Sum_probs=94.2 Template_Neff=11.400 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.+|..++..... .... .-..+++.|...+.+.+..++..++.+|..+..... T Consensus 67 l~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~-----~~~~-~~~~l~~~l~~~l~d~~~~vr~~a~~~l~~l~~~~~ 139 (293) T 5DN7_A 67 FISLLYNLLD-DSNFKVVHGTLQVLHLLVIRLGE-----QVQQ-FLGPVIAASVKVLADNKLVIKQEYMKIFLKLMKEVG 139 (293) T ss_dssp HHHHHHHHTT-CSSHHHHHHHHHHHHHHHHHHGG-----GGGG-GHHHHHHHHHHGGGCCCHHHHHHHHHHHHHHHHHHC T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHHHH-----HHHH-HHHHHHHHHHHHhcCCcHHHHHHHHHHHHHHHHHHC Confidence 4555666666 46778888889888888764221 0111 113467777777777778888889998888875311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . ..+++.+...+.+ .++.++..++.++..+........ ..-..+++.+...+.+. +..++..++.+ T Consensus 140 ~-----~~~~~~l~~~l~~------~~~~vr~~al~~l~~l~~~~~~~~--~~~~~~~~~l~~~l~d~-~~~vr~~a~~~ 205 (293) T 5DN7_A 140 P-----QRVLSLLLENLKH------KHSRVREEVVNICICSLLTYPSED--FDLPKLSFDLAPALVDS-KRRVRQAALEA 205 (293) T ss_dssp H-----HHHHHHHHGGGGC------SCHHHHHHHHHHHHHHHHHSCGGG--SCHHHHHHHHGGGGGCS-SHHHHHHHHHH T ss_pred H-----HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhCCccc--CCHHHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 1 1244555555554 367788888888888876432211 11124566677777766 78888889888 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) +..+... T Consensus 206 l~~l~~~ 212 (293) T 5DN7_A 206 FAVLASS 212 (293) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 8887653 No 334 >4HM9_A Beta-catenin-like protein 1; all alpha-helical, armadillo repeats, PROTEIN; 3.1001A {Homo sapiens} Probab=87.21 E-value=0.04 Score=59.57 Aligned_cols=135 Identities=14% Similarity=0.062 Sum_probs=91.1 Template_Neff=8.100 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDE---------SAKQQVYQLGGICKLVDLLRS------PNQNVQQAAAGA 310 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~---------~~~~~li~~~IL~~Ll~lL~s------~d~eVr~~AL~a 310 (747) .++.|+.++.+.+..+...++.+|..+..... .....+...++++.|+..+.. .+...+..++.+ T Consensus 147 ~i~~Lv~LL~~~n~di~~~a~~~L~~Lt~~~~~~~~~~~~~~l~~~l~e~g~l~~Lv~~L~~l~e~~~~d~~~~~~al~i 226 (568) T 4HM9_A 147 AVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDALVDGQVVALLVQNLERLDESVKEEADGVHNTLAI 226 (568) T ss_dssp HHHHHHHGGGCSSHHHHHHHHHHHHHHTCHHHHTTCHHHHHHHHHHHHHTTHHHHHHHHHTTCCTTSHHHHHHHHHHHHH T ss_pred hHHHHHHHhCCCCHHHHHHHHHHHHHHhCCccccCChhhHHHHHHHHHhCCHHHHHHHHHhcccccccchHHHHHHHHHH Confidence 45566677776667788888888888875432 112333445677777777765 455677888999 Q NP_000290.2 311 LRNLVFRSTTNKLETRRQNGIREAVSLLRRTG--NAEIQKQLTGLLWNLSST-DELKEELIA-DALPVLADRVII 381 (747) Q Consensus 311 Ls~La~~~~~~~~~ll~~~IL~~Ll~lL~ss~--d~eVr~~AL~aLsnLas~-~~~~~~Lve-giLe~Lv~LL~~ 381 (747) |.+++...+.....+...+++..|+.++. .. ....+..+..+|..|+.. ......+.. ++++.|+.+|.. T Consensus 227 L~nL~~~~~~~~~~i~~~g~l~~Ll~lL~-~~~~~~~~k~~AaeiL~~L~~~~~~~r~~l~~~g~I~~LL~lL~~ 300 (568) T 4HM9_A 227 VENMAEFRPEMCTEGAQQGLLQWLLKRLK-AKMPFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSV 300 (568) T ss_dssp HHHHHHHCGGGHHHHCCCCCHHHHHHHHH-SSCCCCHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHHGG T ss_pred HHHHhccCHHHHHHHHHCCHHHHHHHHHH-cCCCCHHHHHHHHHHHHHHHcCCHHHHHHHHhCchHHHHHHHHHh Confidence 99888653332223344567888888886 33 456788899999999875 344444444 888989988864 No 335 >6S47_Bi 60S ribosomal protein L2-A, 60S; New1, ABCF, Ribosomal Protein, Recycling; HET: ATP; 3.28A {Saccharomyces cerevisiae} Probab=87.16 E-value=0.035 Score=61.24 Aligned_cols=155 Identities=12% Similarity=0.055 Sum_probs=101.1 Template_Neff=11.700 Q NP_000290.2 546 SDAIRTYLNLMGKS-KKDATLEACAGALQNLTASK-GLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 546 ~G~I~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s-~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) .++++.|..++. + .++.++..++.+|..++... .. . ....+. ..+++.|...+.+.++.++..++.+|..++ T Consensus 42 ~~il~~l~~~l~-~~~~~~vr~~a~~~L~~l~~~~~~~---~-~~~~~~-~~~~~~l~~~l~~~~~~vr~~a~~~L~~l~ 115 (972) T 6S47_Bi 42 WKIVDVLSKFIK-PKNPSLVRESAMLIISNIAQFFSGK---P-PQEAYL-LPFFNVALDCISDKENTVKRAAQHAIDSLL 115 (972) T ss_pred ccHHHHHHHHcC-CCCCHHHHHHHHHHHHHHHhcCCCh---h-hcHHHH-HHHHHHHHHHhCCCCHHHHHHHHHHHHHHH Confidence 346777777777 4 56778888999998887643 10 0 001111 236777778888778889999999999887 Q NP_000290.2 624 RHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 624 ~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) ..... ......+++.|..++.+. .++.++..++.+|+.++..............+++.|+..+.+. ++.++.. T Consensus 116 ~~~~~-~~~~~~~~~~l~~~l~~~-----~~~~vr~~a~~~l~~i~~~~~~~~~~~~~~~~~~~l~~~l~d~-~~~vr~~ 188 (972) T 6S47_Bi 116 NCFPM-EALTCFVLPTILDYLSSG-----AKWQAKMAALSVVDRIREDSANDLLELTFKDAVPVLTDVATDF-KPELAKQ 188 (972) T ss_pred hcCCH-HhhHhchHHHHHHHcCCC-----CCHHHHHHHHHHHHHHHhhCCHHHHHHHHHHHHHHHHHHhcCC-CHHHHHH Confidence 65111 111113566677776652 1278889999999998554322211112234677777788766 7889999 Q NP_000290.2 704 ARLLLSDMWS 713 (747) Q Consensus 704 AL~aLsnL~~ 713 (747) ++.+|..+.. T Consensus 189 a~~~L~~l~~ 198 (972) T 6S47_Bi 189 GYKTLLDYVS 198 (972) T ss_pred HHHHHHHHHH Confidence 9999988775 No 336 >6QH5_B AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=87.12 E-value=0.034 Score=55.81 Aligned_cols=142 Identities=13% Similarity=0.105 Sum_probs=94.9 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+. ++++.++..++.+|..+....+. . ...+++.+...+.+.++.++..++.+|..+..... T Consensus 50 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 118 (592) T 6QH5_B 50 LFPDVVNCMQ-TDNLELKKLVYLYLMNYAKSQPD--------M--AIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKI 118 (592) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCHH--------H--HHHHHHHHHHHccCCCHHHHHHHHHHHHHHcchhh Confidence 4555666666 46677888888888887654221 1 13456667777778888899999999888765311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...+++.+...+.+ .++.++..++.+|..+....+.. ......++.+...+.+. ++.++..++.+ T Consensus 119 -----~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~---~~~~~~~~~l~~~l~d~-~~~vr~~a~~~ 183 (592) T 6QH5_B 119 -----TEYLCEPLRKCLKD------EDPYVRKTAAVCVAKLHDINAQM---VEDQGFLDSLRDLIADS-NPMVVANAVAA 183 (592) T ss_pred -----HHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCchh---hcCccHHHHHHHHhCCC-CHHHHHHHHHH Confidence 12345556666655 36788899999999887643221 12234567777777765 77888889888 Q NP_000290.2 708 LSDMWSSK 715 (747) Q Consensus 708 LsnL~~~~ 715 (747) |..+.... T Consensus 184 l~~~~~~~ 191 (592) T 6QH5_B 184 LSEISESH 191 (592) T ss_pred HHHHHhcC Confidence 88887654 No 337 >5A1V_G ADP-RIBOSYLATION FACTOR 1, COATOMER SUBUNIT; TRANSPORT PROTEIN, COPI, COATOMER, COATED; 21.0A {SACCHAROMYCES CEREVISIAE} Probab=87.07 E-value=0.037 Score=61.89 Aligned_cols=105 Identities=19% Similarity=0.265 Sum_probs=67.3 Template_Neff=10.900 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL-QSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL-~s~d~eVr~~AL~aLsnLa~~ 625 (747) ..++.|..++. +.++.++..|+.+|..+..... . ....+..++..+ .+.+..++..++.+|..+... T Consensus 259 ~~~~~L~~~l~-~~~~~vr~~a~~~L~~l~~~~~---------~--~~~~~~~l~~~l~~~~~~~vr~~al~~L~~l~~~ 326 (968) T 5A1V_G 259 RFIRCIYNLLQ-SSSPAVKYEAAGTLVTLSSAPT---------A--IKAAAQCYIDLIIKESDNNVKLIVLDRLVELKEH 326 (968) T ss_dssp HHHHHHHHSCC-SSSCSSCCTTHHHHTGGGCSTH---------H--HHHHHHHHHHHHHCCCCCCTTCCCCSCSSSSCSC T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHhCCCHH---------H--HHHHHHHHHHHHHhcCChHHHHHHHHHHHHHhhC Confidence 35666777777 4667788888888887765311 0 123455566666 566778888999999988753 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) +.....+ ..+++.+...+.+ .+..++..++.+|..+.. T Consensus 327 ~~~~~~~-~~~~~~l~~~l~~------~~~~vr~~al~~L~~l~~ 364 (968) T 5A1V_G 327 PAHERVL-QDLVMDILRVLST------PDLEVRKKTLQLALDLVS 364 (968) T ss_dssp CSSCSSC-SHHHHHHTSCSSS------SCHHHHHHHHHHHHHHSS T ss_pred cchHHHH-HHHHHHHHHHhCC------CCHHHHHHHHHHHHHHcC Confidence 2211111 2345556666655 356788888888888765 No 338 >3TJZ_B ADP-ribosylation factor 1, Coatomer subunit; protein trafficking, Golgi membrane, protein; HET: GNP; 2.9A {Saccharomyces cerevisiae} Probab=86.96 E-value=0.036 Score=52.53 Aligned_cols=16 Identities=25% Similarity=-0.029 Sum_probs=8.2 Template_Neff=12.100 Q NP_000290.2 697 SPKAAEAARLLLSDMW 712 (747) Q Consensus 697 d~eVr~aAL~aLsnL~ 712 (747) ++.++..++.+|..+. T Consensus 225 ~~~~~~~~~~~l~~~~ 240 (355) T 3TJZ_B 225 SPFAYCMMIRVASRQL 240 (355) T ss_pred CHHHHHHHHHHHHHhC Confidence 4445555555555544 No 339 >2IW3_B ELONGATION FACTOR 3A; ACETYLATION, ATP-BINDING, ELONGATION FACTOR, PROTEIN; HET: MSE, ADP, SO4; 2.4A {SACCHAROMYCES CEREVISIAE} Probab=86.93 E-value=0.037 Score=61.15 Aligned_cols=151 Identities=9% Similarity=0.010 Sum_probs=98.6 Template_Neff=11.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.|+..+. +.++.++..++.++..+...... .... ....+++.+...+.+.++.++..++.+|..++... T Consensus 54 ~~~~~l~~~l~-~~~~~~~~~~~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~d~~~~vr~~a~~~L~~l~~~~ 126 (986) T 2IW3_B 54 HFFGELAKGIK-DKKTAANAMQAVAHIANQSNLSP-----SVEP-YIVQLVPAICTNAGNKDKEIQSVASETLISIVNAV 126 (986) T ss_dssp HHHHHHHHHHT-STTTHHHHHHHHHHHSCTTTCCT-----TTHH-HHHTTHHHHHHHTTCSSHHHHHHHHHHHHHHHHHS T ss_pred HHHHHHHHhhc-CHHHHHHHHHHHHHHHHhccCCc-----chHH-HHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHhc Confidence 35666777776 35566676777777766643221 1111 12356777788888788889999999999887652 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLL-TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL-~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .... ...+++.+...+ .+ .++.++..++.+|..++...+....... ..+++.|..++.+. +..++..|+ T Consensus 127 ~~~~--~~~~l~~l~~~l~~~------~~~~vr~~al~~l~~l~~~~~~~~~~~~-~~i~~~l~~~l~d~-~~~vr~~a~ 196 (986) T 2IW3_B 127 NPVA--IKALLPHLTNAIVET------NKWQEKIAILAAFSAMVDAAKDQVALRM-PELIPVLSETMWDT-KKEVKAAAT 196 (986) T ss_dssp CGGG--HHHHHHHHHHHHHHC------CCHHHHHHHHHHHHHHHHHSHHHHHHHH-HHHHHHHHHHTTCS-CHHHHHHHH T ss_pred CHHH--HHHHHHHHHHHHhhc------CCHHHHHHHHHHHHHHHHHCHHHHHhhH-HHHHHHHHHhcCcC-CHHHHHHHH Confidence 2111 224566677777 44 3678889999999988865332221111 34677788888766 778999999 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..++.. T Consensus 197 ~~l~~l~~~ 205 (986) T 2IW3_B 197 AAMTKATET 205 (986) T ss_dssp HHHHHHGGG T ss_pred HHHHHHHHh Confidence 999888764 No 340 >5NZR_B Coatomer subunit alpha, Coatomer subunit; COPI, coatomer, coated vesicles, Transport; 9.2A {Mus musculus} Probab=86.79 E-value=0.04 Score=61.63 Aligned_cols=105 Identities=19% Similarity=0.265 Sum_probs=67.8 Template_Neff=10.900 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL-QSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL-~s~d~eVr~~AL~aLsnLa~~ 625 (747) ..++.|..++. +.++.++..|+.+|..+..... . ....+..++..+ .+.+..++..++.+|..+... T Consensus 259 ~~~~~L~~~l~-~~~~~vr~~a~~~L~~l~~~~~---------~--~~~~~~~l~~~l~~~~~~~vr~~al~~L~~l~~~ 326 (968) T 5NZR_B 259 RFIRCIYNLLQ-SSSPAVKYEAAGTLVTLSSAPT---------A--IKAAAQCYIDLIIKESDNNVKLIVLDRLVELKEH 326 (968) T ss_dssp HHHHHHHHHTS-CCSHHHHHHHHHHHHHHCCCHH---------H--HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHTCC T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHhCCCHH---------H--HHHHHHHHHHHHHhcCChHHHHHHHHHHHHHhhC Confidence 35667777777 4667788888888887765311 0 123455566666 566788899999999988753 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) ......+ ..+++.+...+.+ .+..++..++.+|..+.. T Consensus 327 ~~~~~~~-~~~~~~l~~~l~~------~~~~vr~~al~~L~~l~~ 364 (968) T 5NZR_B 327 PAHERVL-QDLVMDILRVLST------PDLEVRKKTLQLALDLVS 364 (968) T ss_dssp TTCCHHH-HHHHHHHHHGGGS------CCHHHHHHHHHHHHTTCS T ss_pred cchHHHH-HHHHHHHHHHhCC------CCHHHHHHHHHHHHHHcC Confidence 2211111 2345556666655 356788888888888765 No 341 >4P6Z_B BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=86.78 E-value=0.037 Score=55.91 Aligned_cols=142 Identities=14% Similarity=0.108 Sum_probs=93.4 Template_Neff=12.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+. +.++.++..++.+|..+....+. . ...+++.+...+.+.++.++..|+.+|..+..... T Consensus 66 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 134 (600) T 4P6Z_B 66 LFPDVVNCMQ-TDNLELKKLVYLYLMNYAKSQPD--------M--AIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKI 134 (600) T ss_pred hHHHHHHhcc-CCCHHHHHHHHHHHHHhccCCHh--------H--HHHHHHHHHHHccCCCHHHHHHHHHHHhcCCchHH Confidence 4455666666 46677888888888877653221 1 12355666667777788888889888888764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...+++.+...+.+ .++.++..++.+|..+....+.. +....+++.+...+.+. ++.++..++.+ T Consensus 135 -----~~~~~~~l~~~l~~------~~~~vr~~a~~~L~~l~~~~~~~---~~~~~~~~~l~~~l~~~-~~~vr~~a~~~ 199 (600) T 4P6Z_B 135 -----TEYLCEPLRKCLKD------EDPYVRKTAAVCVAKLHDINAQL---VEDQGFLDTLKDLISDS-NPMVVANAVAA 199 (600) T ss_pred -----HHHHHHHHHHhcCC------CCHHHHHHHHHHHHHHHhhChHH---hhccChHHHHHHHhcCC-CHHHHHHHHHH Confidence 12345556666655 36788899999999887643221 11234567777777766 77888999998 Q NP_000290.2 708 LSDMWSSK 715 (747) Q Consensus 708 LsnL~~~~ 715 (747) |..+.... T Consensus 200 l~~l~~~~ 207 (600) T 4P6Z_B 200 LSEIAESH 207 (600) T ss_pred HHHHHhhC Confidence 88887653 No 342 >5VCH_A Kap123; Bidding yeast karyopherin, 23 HEAT; HET: MSE; 2.35A {Kluyveromyces lactis} Probab=86.69 E-value=0.038 Score=60.48 Aligned_cols=153 Identities=11% Similarity=0.110 Sum_probs=80.3 Template_Neff=12.900 Q NP_000290.2 550 RTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLL-QSGNSDVVRSGASLLSNMSRH-PL 627 (747) Q Consensus 550 ~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL-~s~d~eVr~~AL~aLsnLa~~-~e 627 (747) +.+...+. +.++.++..++.++..++..... ... ....+++.++..+ .+.++.++..++.++..+... +. T Consensus 869 ~~l~~~~~-~~~~~~r~~~~~~l~~l~~~~~~------~~~-~~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~~~~~~ 940 (1116) T 5VCH_A 869 PVILQLCQ-SKSKNKRSFAVGALSEIALGMRD------ENP-FIQELLEALIISLTNDKSLEVRCNASYGVGLLIEYSSF 940 (1116) T ss_dssp HHHHHHTT-CSCHHHHHHHHHHHHHHHHHHGG------GCT-THHHHHHHHHHHHHHCSCHHHHHHHHHHHHHHHHHCCS T ss_pred HHHHHHcC-CCCHHHHHHHHHHHHHHHHhCCC------Cch-hHHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHHhCCc Confidence 33444443 24456677777777777653221 111 1134555555553 345678888999999888765 21 Q NP_000290.2 628 L-HRVMGNQVFPEVTRLLTSHTGN----------TSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA 696 (747) Q Consensus 628 ~-~~ll~~giI~~Ll~LL~s~s~~----------~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~ 696 (747) . ...+ ..+++.+...+...... ......++..++.+|+.+....+... .-..+++.++..+.... T Consensus 941 ~~~~~~-~~il~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~---~~~~~l~~~~~~l~~~~ 1016 (1116) T 5VCH_A 941 DVSAIY-SPVLKSLYEILSVADEKNLATEDDEATKEIVDRTFSNVCGCVARMILKHQNLV---PLEHTIPALLSHLPFNT 1016 (1116) T ss_dssp CCHHHH-HHHHHHHHHHHHHHHHHHHSCSSCHHHHHHHHHHHHHHHHHHHHHHHHCGGGS---CHHHHHHHHHTTCSCSS T ss_pred chhhhH-HHHHHHHHHHhcchhHhccCCCCchhhHHHHHHHHHHHHHHHHHHHHHCcccC---CHHHHHHHHHhcCCCCC Confidence 1 1111 23555565555421000 00245667788888888876533211 11234555555553221 Q NP_000290.2 697 SPKAAEAARLLLSDMWSS 714 (747) Q Consensus 697 d~eVr~aAL~aLsnL~~~ 714 (747) +...+..++.+|..+... T Consensus 1017 ~~~~~~~~~~~l~~l~~~ 1034 (1116) T 5VCH_A 1017 AFEEYDPIFKLFLKLFQE 1034 (1116) T ss_dssp CGGGHHHHHHHHHHHHHT T ss_pred chhhhHHHHHHHHHHHHh Confidence 455666677777666653 No 343 >6BCU_A mTOR, Target of rapamycin complex; PIKK, TRANSFERASE; HET: ATP, GTP; 3.43A {Homo sapiens} Probab=86.66 E-value=0.04 Score=67.95 Aligned_cols=131 Identities=8% Similarity=0.114 Sum_probs=72.7 Template_Neff=11.600 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-L 627 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e 627 (747) ++.|...+.+.....++..++.+|..++..... ....+ -..+++.+...+.+.++.++..++.+|+.++... . T Consensus 952 ~~~l~~~l~~~~~~~~~~~a~~~l~~i~~~~~~-----~~~~~-l~~l~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~ 1025 (2549) T 6BCU_A 952 MVALMRIFRDQSLSHHHTMVVQAITFIFKSLGL-----KCVQF-LPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKS 1025 (2549) T ss_dssp HHHHHHHCSSTTHHHHHHHHHHHHHHHHHHHTT-----GGGGG-HHHHHHHHHHHHHHSCHHHHHHHHHHHHHHHHHHGG T ss_pred HHHHHHHHcCCChHHHHHHHHHHHHHHHHHcCc-----chHHh-HHHHHHHHHHHHhcCCHHHHHHHHHHHHHHHHHHHH Confidence 555666665222345777888888888764321 11111 2456777778887777788888999998887541 1 Q NP_000290.2 628 L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRS 694 (747) Q Consensus 628 ~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s 694 (747) . ..+. ..+++.+..++.. ...++..++.+|..++........... ..+++.++..+.+ T Consensus 1026 ~~~~~~-~~i~~~l~~~~~~-------~~~v~~~~~~~l~~l~~~~~~~~~~~~-~~l~~~l~~~l~~ 1084 (2549) T 6BCU_A 1026 HIRPYM-DEIVTLMREFWVM-------NTSIQSTIILLIEQIVVALGGEFKLYL-PQLIPHMLRVFMH 1084 (2549) T ss_dssp GGGGGH-HHHHHHHHHTCCS-------CHHHHHHHHHHHHHHHHHHGGGGGGTH-HHHHHHHHHHHHS T ss_pred hcHHhH-HHHHHHHHHHHhc-------CHHHHHHHHHHHHHHHHHhcHhhHhHH-HHHHHHHHHHHhc Confidence 1 1111 2234444444433 244677788888887654222111111 2345555555543 No 344 >6BCX_B mTOR, Target of rapamycin complex; PIKK, TRANSFERASE; HET: ATP; 3.0A {Homo sapiens} Probab=86.66 E-value=0.04 Score=67.95 Aligned_cols=131 Identities=8% Similarity=0.114 Sum_probs=72.7 Template_Neff=11.600 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP-L 627 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~-e 627 (747) ++.|...+.+.....++..++.+|..++..... ....+ -..+++.+...+.+.++.++..++.+|+.++... . T Consensus 952 ~~~l~~~l~~~~~~~~~~~a~~~l~~i~~~~~~-----~~~~~-l~~l~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~ 1025 (2549) T 6BCX_B 952 MVALMRIFRDQSLSHHHTMVVQAITFIFKSLGL-----KCVQF-LPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKS 1025 (2549) T ss_pred HHHHHHHHcCCChHHHHHHHHHHHHHHHHHcCc-----chHHh-HHHHHHHHHHHHhcCCHHHHHHHHHHHHHHHHHHHH Confidence 555666665222345777888888888764321 11111 2456777778887777788888999998887541 1 Q NP_000290.2 628 L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRS 694 (747) Q Consensus 628 ~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s 694 (747) . ..+. ..+++.+..++.. ...++..++.+|..++........... ..+++.++..+.+ T Consensus 1026 ~~~~~~-~~i~~~l~~~~~~-------~~~v~~~~~~~l~~l~~~~~~~~~~~~-~~l~~~l~~~l~~ 1084 (2549) T 6BCX_B 1026 HIRPYM-DEIVTLMREFWVM-------NTSIQSTIILLIEQIVVALGGEFKLYL-PQLIPHMLRVFMH 1084 (2549) T ss_pred hcHHhH-HHHHHHHHHHHhc-------CHHHHHHHHHHHHHHHHHhcHhhHhHH-HHHHHHHHHHHhc Confidence 1 1111 2234444444433 244677788888887654222111111 2345555555543 No 345 >5IFE_C Splicing factor 3B subunit 5; pre-mRNA splicing, U2 snRNP, essential; 3.1A {Homo sapiens} Probab=86.43 E-value=0.045 Score=64.20 Aligned_cols=110 Identities=15% Similarity=0.148 Sum_probs=59.4 Template_Neff=9.800 Q NP_000290.2 249 KAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ 328 (747) Q Consensus 249 ~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~ 328 (747) .+...+.+.+..++..++.+|..++..........+...++..+...+.+.+..++..++.+|..++............. T Consensus 935 ~L~~~L~~~~~~vR~~A~~~L~~l~~~~~~~~~~~~~~~l~~~L~~~L~d~~~~vr~~al~aL~~l~~~~~~~~l~~~l~ 1014 (1304) T 5IFE_C 935 TVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIK 1014 (1304) T ss_pred HHHHHhcCCCHHHHHHHHHHHHHHHHhccCcCHHHHHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhhChHHhcccHH Confidence 33344445566777778888877765322111111112345556666665566777777777777764432111001112 Q NP_000290.2 329 NGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 329 ~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) .+++.+...+. ..+..++..++.++..++. T Consensus 1015 ~ll~~L~~~L~-~~~~~Vr~~ai~~L~~i~~ 1044 (1304) T 5IFE_C 1015 DLLPRLTPILK-NRHEKVQENCIDLVGRIAD 1044 (1304) T ss_pred hHHHHHHHHhC-CCCHHHHHHHHHHHHHHHh Confidence 35555666665 4455667777777776665 No 346 >6AHD_1 Pre-mRNA-processing-splicing factor 8, Thioredoxin-like protein; Spliceosome, SPLICING; HET: IHP, GTP; 3.8A {Homo sapiens} Probab=86.43 E-value=0.045 Score=64.20 Aligned_cols=110 Identities=15% Similarity=0.148 Sum_probs=59.4 Template_Neff=9.800 Q NP_000290.2 249 KAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ 328 (747) Q Consensus 249 ~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll~~ 328 (747) .+...+.+.+..++..++.+|..++..........+...++..+...+.+.+..++..++.+|..++............. T Consensus 935 ~L~~~L~~~~~~vR~~A~~~L~~l~~~~~~~~~~~~~~~l~~~L~~~L~d~~~~vr~~al~aL~~l~~~~~~~~l~~~l~ 1014 (1304) T 6AHD_1 935 TVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIK 1014 (1304) T ss_pred HHHHHhcCCCHHHHHHHHHHHHHHHHhccCcCHHHHHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhhChHHhcccHH Confidence 33344445566777778888877765322111111112345556666665566777777777777764432111001112 Q NP_000290.2 329 NGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 329 ~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) .+++.+...+. ..+..++..++.++..++. T Consensus 1015 ~ll~~L~~~L~-~~~~~Vr~~ai~~L~~i~~ 1044 (1304) T 6AHD_1 1015 DLLPRLTPILK-NRHEKVQENCIDLVGRIAD 1044 (1304) T ss_pred hHHHHHHHHhC-CCCHHHHHHHHHHHHHHHh Confidence 35555666665 4455667777777776665 No 347 >6LTJ_L Histone H3.2, Histone H4, Histone; Chromatin remodeler, Complex, GENE REGULATION; 3.7A {Xenopus laevis} Probab=86.40 E-value=0.056 Score=63.52 Aligned_cols=152 Identities=14% Similarity=0.061 Sum_probs=89.3 Template_Neff=5.100 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-----NSD----------VVRSGASLLSNMSRHPL 627 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-----d~e----------Vr~~AL~aLsnLa~~~e 627 (747) .+++.++.+|.+|+....- .. ....+ ...++..|+.++... ++. .+..|+.+|+.|+..+. T Consensus 1065 ~LRenaLviLaNIAg~LdL--s~-~~e~I-~~~ild~LLhwlv~~sa~a~Dp~~~~~~~~~lSp~~lALEaLsKLsv~d~ 1140 (1295) T 6LTJ_L 1065 MLRENTLVTLANISGQLDL--SP-YPESI-CLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDN 1140 (1295) T ss_dssp HHHHHHHHHHHHHGGGCCC--SS-SCHHH-HHHHHHHHHHHHHCCSSSSSSCCTTSCTTCCCCHHHHHHHHHHHHHTSHH T ss_pred HHHHHHHHHHHHHHcccCC--CC-CChHh-HHHHHHHHHHHHcCcChhcCChhhccCCCCCCCHHHHHHHHHHHHhCCCc Confidence 4566788888888764220 00 01111 112455555554321 111 12348899999987643 Q NP_000290.2 628 LH-RVMG-------NQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK-QYFSSSMLNNIINLCRSSA-- 696 (747) Q Consensus 628 ~~-~ll~-------~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~-~Lve~giL~~Ll~LL~s~~-- 696 (747) +. .++. ..++..|+.+|... .+..+++.++.+|.+|+........ ...+.+.+..|+.+|+... T Consensus 1141 N~dlLlat~p~srle~Ll~~LV~lL~~~-----ed~~lrE~AL~lL~~Ls~~~~~~ar~ia~~~g~I~~LV~fLE~~~~~ 1215 (1295) T 6LTJ_L 1141 NVDLILATPPFSRLEKLYSTMVRFLSDR-----KNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAA 1215 (1295) T ss_dssp HHHHHHTSSCHHHHHHHHHHHHHHHHHC-----SSHHHHHHHHHHHHHHHHHCHHHHHHHHTSTTHHHHHHHHHHHHHHH T ss_pred hHHHHHhCCCHHHHHHHHHHHHHHhcCC-----CCHHHHHHHHHHHHHHHcCCHHHHHHHHHhcCHHHHHHHHHHHHHHH Confidence 32 2222 23566677777652 2456788999999999875433322 3334567888888876430 Q NP_000290.2 697 ---------------------SPKAAEAARLLLSDMWSSKELQGVLRQ 723 (747) Q Consensus 697 ---------------------d~eVr~aAL~aLsnL~~~~~~~~~~~~ 723 (747) ...+++.|+.+|..|+...+-...+.+ T Consensus 1216 ~~~~~~~~~~~~~~npe~~gtS~~m~rRAA~aL~~La~vp~NR~~F~~ 1263 (1295) T 6LTJ_L 1216 TQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENHSEFTL 1263 (1295) T ss_dssp HHHCC--------------CCCSHHHHHHHHHHHHHHTTSSSHHHHTT T ss_pred HHHHHHHHHHHHhhCCCCCCCCHHHHHHHHHHHHHHhcChhhHHHHHH Confidence 134567788899999887777776665 No 348 >6CRI_R Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=86.18 E-value=0.043 Score=55.49 Aligned_cols=139 Identities=17% Similarity=0.118 Sum_probs=92.2 Template_Neff=12.500 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .+..++..+. +.+..++..++.+|..+....+. . ...+++.+...+.+.++.++..++.+|..+..... T Consensus 63 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 131 (585) T 6CRI_R 63 GQLECLKLIA-SQKFTDKRIGYLGAMLLLDERQD--------V--HLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEM 131 (585) T ss_pred HHHHHHHHHh-CCCchHHHHHHHHHHHhCCCChH--------H--HHHHHHHHHHHhcCCCHHHHHHHHHHHHhhCCHHH Confidence 3455666776 46777888888888887754221 1 12345666777777778888888888887764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...+++.+...+.+ .++.++..++.+|..+....+... ...++.+...+.+. ++.++..++.+ T Consensus 132 -----~~~~~~~l~~~l~~------~~~~vr~~a~~~L~~~~~~~~~~~-----~~~~~~l~~~l~~~-~~~vr~~a~~~ 194 (585) T 6CRI_R 132 -----CRDLAGEVEKLLKT------SNSYLRKKAALCAVHVIRKVPELM-----EMFLPATKNLLNEK-NHGVLHTSVVL 194 (585) T ss_pred -----HHHHHHHHHHHHhC------CChHHHHHHHHHHHHHHHHCHHHH-----HHHHHHHHHHHcCC-CHHHHHHHHHH Confidence 11345556666665 367888899999998876432221 24566777777665 77888888888 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) |..+... T Consensus 195 l~~l~~~ 201 (585) T 6CRI_R 195 LTEMCER 201 (585) T ss_pred HHHHHHh Confidence 8887643 No 349 >5DFZ_B Vacuolar protein sorting-associated protein 38; Vps34, Vps15, Vps30, Vps38, Autophagy; 4.4A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=85.86 E-value=0.051 Score=64.44 Aligned_cols=292 Identities=12% Similarity=0.004 Sum_probs=157.7 Template_Neff=9.900 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQ-AIGAYYIQHTCFQDESA--KQQVYQLGGICKLVDLL---RSPNQNVQQAAAGALRNLVFRS 318 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr-~sAL~aLsnLs~~~~~~--~~~li~~~IL~~Ll~lL---~s~d~eVr~~AL~aLs~La~~~ 318 (747) .+++.|+..+.+.+..++ ..++..|..+....... ........+++.|+.++ .+.++.++..+..+|..+.... T Consensus 464 ~~i~~L~~~l~d~~~~vR~~~a~~~L~~l~~~~~~~~~~~~~~~~~~lp~Li~~L~~~~d~~~~vr~~aa~~l~~~~~~~ 543 (1460) T 5DFZ_B 464 RVVPYFVCCFEDSDQDVQALSLLTLIQVLTSVRKLNQLNENIFVDYLLPRLKRLLISNRQNTNYLRIVFANCLSDLAIII 543 (1460) T ss_pred cchHHHHHHhcCCCHHHHHHHHHHHHHHhcCCCCccCCccccCcCChHHHHHHHHHhccCCCHHHHHHHHHHHHHHHHHc Confidence 455667777777788889 89999998886543211 11223345678888888 7777888888888887774321 Q NP_000290.2 319 TTN------------KLETRRQNGIREAVSL----LRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIP 382 (747) Q Consensus 319 ~~~------------~~~ll~~~IL~~Ll~l----L~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL~~~ 382 (747) ... .........++.+..+ +. +.++.++..++.+|..+........ ....+++.|+.+|..+ T Consensus 544 ~~~~l~~l~~~~~~~~~~~l~~~~~~~l~~ll~~~l~-d~~~~VR~~A~~aL~~l~~~~~~~~-~~~~~l~~Li~ll~d~ 621 (1460) T 5DFZ_B 544 NRFQEFTFAQHCNDNSSTKYSAKLIQSVEDLTVSFLT-DNDTYVKMALLQNILPLCKFFGRER-TNDIILSHLITYLNDK 621 (1460) T ss_pred CHHHHHHHHHhcccChhHHHHcChHHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHhccccccc-cHHhHHHHHHHHhcCC Confidence 100 0001111223333333 33 4567889999999988876422111 1135666677766321 Q NP_000290.2 383 FSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCV 462 (747) Q Consensus 383 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 462 (747) +++|-.+|..+|.+--. .++ ....+ ..++..|...+. T Consensus 622 ----------------~~~VR~~a~~aL~~i~~------~~~---------------~~~~~---~~~i~~L~~~l~--- 658 (1460) T 5DFZ_B 622 ----------------DPALRVSLIQTISGISI------LLG---------------TVTLE---QYILPLLIQTIT--- 658 (1460) T ss_pred ----------------CHHHHHHHHHHHHHHHh------hcC---------------chhhc---hhHHHHHHHHhc--- Confidence 35555566666543110 000 00000 011222222111 Q NP_000290.2 463 AASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGW 542 (747) Q Consensus 463 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ni~~~~~ 542 (747) |.. .+| | .+|-.+. +.+.. ..+.. . T Consensus 659 ------d~~----------------~~v--R-----~~a~~aL------~~~~~-----------------~~~~~--~- 683 (1460) T 5DFZ_B 659 ------DSE----------------ELV--V-----ISVLQSL------KSLFK-----------------TGLIR--K- 683 (1460) T ss_pred ------CCC----------------HHH--H-----HHHHHHH------HHhcC-----------------Ccchh--h- Confidence 110 000 0 0111111 00000 00000 0 Q NP_000290.2 543 LYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNM 622 (747) Q Consensus 543 lve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnL 622 (747) ....++++.|..++. +.++.++..|+.+|..+...... . . ....+++.|+.+|.++++.++..|+.+|..+ T Consensus 684 ~~~~~~i~~l~~~l~-d~~~~VR~~A~~al~~l~~~~~~------~-~-~~~~~l~~L~~~l~d~~~~vr~~a~~aL~~~ 754 (1460) T 5DFZ_B 684 KYYIDISKTTSPLLL-HPNNWIRQFTLMIIIEIINKLSK------A-E-VYCILYPIIRPFFEFDVEFNFKSMISCCKQP 754 (1460) T ss_pred cccchhHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHhCC------H-H-HHHHHHHHHHHHhcCCCHHHHHHHHHHhCCC Confidence 001246778888888 57889999999999988764221 1 1 1246788899999999999999999999998 Q NP_000290.2 623 SRHPLLH----RVMGNQVFPEVTRLLT 645 (747) Q Consensus 623 a~~~e~~----~ll~~giI~~Ll~LL~ 645 (747) ....... ..+..+.+..+..++. T Consensus 755 ~~~~~~~~~~~~~~~~~~~~~~~~~~~ 781 (1460) T 5DFZ_B 755 VSRSVYNLLCSWSVRASKSLFWKKIIT 781 (1460) T ss_pred CCHHHHHHHHHHHHHhchhHHHHHHHH Confidence 7763331 2244455555555554 No 350 >2QNA_A Importin subunit beta-1, Snurportin-1; Nuclear transport, import of spliceosomal; HET: SO4; 2.84A {Homo sapiens} Probab=85.76 E-value=0.046 Score=56.33 Aligned_cols=154 Identities=11% Similarity=0.064 Sum_probs=95.8 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQS--GNSDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s--~d~eVr~~AL~aLsnLa 623 (747) .++.|+..+. +.+ ..++..++.+|..++...+. . .... ....+++.+...+.+ .++.++..++.+|..++ T Consensus 4 l~~~l~~~l~-~~~~~~~~~~~a~~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~~~vr~~a~~~l~~l~ 77 (762) T 2QNA_A 4 LIPQLVANVT-NPNSTEHMKESTLEAIGYICQDIDP---E-QLQD-KSNEILTAIIQGMRKEEPSNNVKLAATNALLNSL 77 (762) T ss_pred hHHHHHHHhc-CCCCCHHHHHHHHHHHHHHHHhCCH---h-hcHH-HHHhHHHHHHHHhcCCCCCHHHHHHHHHHHHHHH Confidence 4566777776 344 67888899999888764221 0 0111 113456677777764 35788999999999988 Q NP_000290.2 624 RHP-LL-H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 624 ~~~-e~-~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) ... .. . ......+++.+...+.+ .++.++..++.+|..++..............+++.+...+.+. ++.+ T Consensus 78 ~~~~~~~~~~~~~~~i~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~l~~~l~~~~~~~-~~~v 150 (762) T 2QNA_A 78 EFTKANFDKESERHFIMQVVCEATQC------PDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSD-IDEV 150 (762) T ss_pred hcCCccCCcchhHHhHHHHHHHHhCC------CCHHHHHHHHHHHHHHHHhCchhhHHhhHHhHHHHHHHHcCCC-CHHH Confidence 652 11 1 01122345555566654 3678888999999988764332222222223566666677655 7788 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..+... T Consensus 151 ~~~a~~~l~~l~~~ 164 (762) T 2QNA_A 151 ALQGIEFWSNVCDE 164 (762) T ss_pred HHHHHHHHHHHHhc Confidence 88888888887754 No 351 >3WOZ_C CLIP-associating protein 2; HEAT Repeat, Microtubule binding, Tubulin; HET: MSE; 2.2A {Mus musculus} Probab=85.74 E-value=0.049 Score=48.60 Aligned_cols=154 Identities=11% Similarity=0.036 Sum_probs=91.0 Template_Neff=11.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) ..++.++..+. +.++..|..++..|..++..... . .... -..++..+...+.+.+..++..++.++..++.. T Consensus 5 ~~~~~~~~~l~-~~~w~~R~~al~~l~~~~~~~~~---~-~~~~--~~~i~~~l~~~l~d~~~~v~~~al~~l~~l~~~~ 77 (232) T 3WOZ_C 5 EDVAEVLNRCA-SSNWSERKEGLLGLQNLLKNQRT---L-SRIE--LKRLCEIFTRMFADPHGKVFSMFLETLVDFIQVH 77 (232) T ss_dssp CCHHHHHHHHT-CSSHHHHHHHHHHHHHHHHTTCC---C-CHHH--HHHHHHHHHHHTTCCCHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHh-CCCHHHHHHHHHHHHHHHhcCcc---c-CHHH--HHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHc Confidence 45666777777 47888899999999888864221 0 0111 135666777777777888999999999988865 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ..........+++.++..+.+. ....++..+..+|..+....+. ..++ ..+++.+...+.+. ++.++..++ T Consensus 78 ~~~~~~~~~~ll~~ll~~l~d~-----~~~~vr~~a~~~l~~i~~~~~~--~~~~-~~l~~~l~~~~~~~-~~~~r~~~l 148 (232) T 3WOZ_C 78 KDDLQDWLFVLLTQLLKKMGAD-----LLGSVQAKVQKALDITRESFPN--DLQF-NILMRFTVDQTQTP-SLKVKVAIL 148 (232) T ss_dssp GGGCTTTHHHHHHHHHHHTTTT-----CCHHHHHHHHHHHHHHHHHSCH--HHHH-HHHHHHHTCTTCCC-CHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHhccc-----cCHHHHHHHHHHHHHHHHHCCc--chHH-HHHHHHhhccccCC-CHHHHHHHH Confidence 2111111123555566555441 1456788888888887543211 1111 12233333344433 567777777 Q NP_000290.2 706 LLLSDMWSSKE 716 (747) Q Consensus 706 ~aLsnL~~~~~ 716 (747) .++..++...+ T Consensus 149 ~~l~~l~~~~~ 159 (232) T 3WOZ_C 149 KYIETLAKQMD 159 (232) T ss_dssp HHHHHHHTTSC T ss_pred HHHHHHHHhcC Confidence 77777665533 No 352 >3WOZ_D CLIP-associating protein 2; HEAT Repeat, Microtubule binding, Tubulin; HET: MSE; 2.2A {Mus musculus} Probab=85.74 E-value=0.049 Score=48.60 Aligned_cols=154 Identities=11% Similarity=0.036 Sum_probs=91.0 Template_Neff=11.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) ..++.++..+. +.++..|..++..|..++..... . .... -..++..+...+.+.+..++..++.++..++.. T Consensus 5 ~~~~~~~~~l~-~~~w~~R~~al~~l~~~~~~~~~---~-~~~~--~~~i~~~l~~~l~d~~~~v~~~al~~l~~l~~~~ 77 (232) T 3WOZ_D 5 EDVAEVLNRCA-SSNWSERKEGLLGLQNLLKNQRT---L-SRIE--LKRLCEIFTRMFADPHGKVFSMFLETLVDFIQVH 77 (232) T ss_dssp CCHHHHHHHHH-CSCHHHHHHHHHHHHHHHHTTCC---C-CHHH--HHHHHHHHHHHTTCCCHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHh-CCCHHHHHHHHHHHHHHHhcCcc---c-CHHH--HHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHc Confidence 45666777777 47888899999999888864221 0 0111 135666777777777888999999999988865 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ..........+++.++..+.+. ....++..+..+|..+....+. ..++ ..+++.+...+.+. ++.++..++ T Consensus 78 ~~~~~~~~~~ll~~ll~~l~d~-----~~~~vr~~a~~~l~~i~~~~~~--~~~~-~~l~~~l~~~~~~~-~~~~r~~~l 148 (232) T 3WOZ_D 78 KDDLQDWLFVLLTQLLKKMGAD-----LLGSVQAKVQKALDITRESFPN--DLQF-NILMRFTVDQTQTP-SLKVKVAIL 148 (232) T ss_dssp GGGCGGGHHHHHHHHHHHTTSC-----CCHHHHHHHHHHHHHHHHHSCH--HHHH-HHHHHHHTCSSCCC-CHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHhccc-----cCHHHHHHHHHHHHHHHHHCCc--chHH-HHHHHHhhccccCC-CHHHHHHHH Confidence 2111111123555566555441 1456788888888887543211 1111 12233333344433 567777777 Q NP_000290.2 706 LLLSDMWSSKE 716 (747) Q Consensus 706 ~aLsnL~~~~~ 716 (747) .++..++...+ T Consensus 149 ~~l~~l~~~~~ 159 (232) T 3WOZ_D 149 KYIETLAKQMD 159 (232) T ss_dssp HHHHHHHTTCC T ss_pred HHHHHHHHhcC Confidence 77777665533 No 353 >5DCQ_C artificial repeat proteins (alphaREP3), Fibronectin-binding; adhesin, artificial repeat proteins, complex; HET: FMT; 1.83A {synthetic construct} Probab=85.49 E-value=0.051 Score=45.36 Aligned_cols=47 Identities=15% Similarity=0.166 Sum_probs=25.2 Template_Neff=12.100 Q NP_000290.2 654 SEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMW 712 (747) Q Consensus 654 d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~ 712 (747) ++.++..++.+|..+... ..++.+..++.+. +..++..++.++..+. T Consensus 120 ~~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~ 166 (170) T 5DCQ_C 120 DSDVRRTAAYALGEIGGE-----------RVRAAMEKLAETG-TGFARKVAVNYLETHK 166 (170) T ss_dssp SHHHHHHHHHHHHHHCHH-----------HHHHHHHHHHHHC-CHHHHHHHHHHHHTC- T ss_pred CHHHHHHHHHHHHHhchH-----------HHHHHHHHHHHcC-ChHHHHHHHHHHHhcc Confidence 455666666666555431 1344444555544 5566666766666543 No 354 >4L7M_A Putative uncharacterized protein; HEAT-repeats, Hypothetical, UNKNOWN FUNCTION; HET: MSE, GOL; 2.002A {Thermococcus onnurineus} Probab=85.26 E-value=0.051 Score=48.13 Aligned_cols=143 Identities=17% Similarity=0.105 Sum_probs=85.7 Template_Neff=12.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..+... . .....++.+..++.+.++.++..++.++..++.... T Consensus 120 ~~~~l~~~l~-~~~~~~~~~a~~~l~~~~~~--~----------~~~~~~~~l~~~l~~~~~~~r~~~~~~l~~l~~~~~ 186 (269) T 4L7M_A 120 AAKTLVSLLE-SPDDMMRIETIDVLSKLQPL--E----------DSKLVRTYINELVVSPDLYTKVAGFCLFLNMLNSSA 186 (269) T ss_dssp HHHHHHHHTT-SCCHHHHHHHHHHHTTCCBS--C----------CCHHHHHHHHHHHHCSSHHHHHHHHHHHHHHGGGCS T ss_pred HHHHHHHHcC-CCCHHHHHHHHHHHHhcCCh--h----------HhhchHHHHHHHhcCCCHHHHHHHHHHHHHHHcCCC Confidence 4556666666 35666777777777665321 0 123566777777877778889999999998875311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP-QLAKQYFSSSMLNNIINLCRS--SASPKAAEAA 704 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~-e~~~~Lve~giL~~Ll~LL~s--~~d~eVr~aA 704 (747) ..... ..+++.+...+.+ .++.++..++.+|..+..... ....... +.+..++..+.+ . ++.++..+ T Consensus 187 ~~~~~-~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~~--~~~~~l~~~l~~~~~-~~~vr~~a 256 (269) T 4L7M_A 187 DSGHL-TLILDEIPSLLQN------DNEFIVELALDVLEKALSFPLLENVKIEL--LKISRIVDGLVYREG-APIIRLKA 256 (269) T ss_dssp SCCCG-GGTTTTHHHHHTC------SCHHHHHHHHHHHHHHTTSCCCSCCHHHH--HHHHHHHHHHTTCSS-CHHHHHHH T ss_pred CcchH-HHHHHHHHHHHcC------CCHHHHHHHHHHHHHHcCCccHHHHHHHH--HHHHHHHhhccCCCC-CHHHHHHH Confidence 11111 1245556666665 367888899999988875411 1111111 233344444443 3 67788888 Q NP_000290.2 705 RLLLSDMWS 713 (747) Q Consensus 705 L~aLsnL~~ 713 (747) +.+|..+.. T Consensus 257 ~~~l~~l~~ 265 (269) T 4L7M_A 257 KKVSDLIDS 265 (269) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHH Confidence 888877653 No 355 >4P6Z_B BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=85.10 E-value=0.053 Score=54.64 Aligned_cols=109 Identities=13% Similarity=0.033 Sum_probs=65.8 Template_Neff=12.700 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+....+..........+++.+...+.+.+..++..++.++..+....... T Consensus 176 ~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~l~~~~~~~~~~--- 252 (600) T 4P6Z_B 176 GFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDRE--- 252 (600) T ss_pred ChHHHHHHHhcCCCHHHHHHHHHHHHHHHhhCCCcchhccCHHHHHHHHHHhhcCCHHHHHHHHHHHHHhCCCCHHH--- Confidence 35566666676777788888888888887643321111112245555666666556667777777777766432211 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ...++..+...+. +.++.++..++.++..+.. T Consensus 253 --~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~ 284 (600) T 4P6Z_B 253 --AQSICERVTPRLS-HANSAVVLSAVKVLMKFME 284 (600) T ss_pred --HHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHH Confidence 1234555555565 4566777788888777765 No 356 >5MU7_A Coatomer subunit beta, Coatomer subunit; coatomer, COPI, beta COP, delta; 2.57A {Chaetomium thermophilum var. thermophilum DSM 1495} Probab=85.09 E-value=0.053 Score=50.69 Aligned_cols=101 Identities=9% Similarity=0.074 Sum_probs=54.4 Template_Neff=12.800 Q NP_000290.2 598 PQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK 677 (747) Q Consensus 598 ~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~ 677 (747) +.+...+.+.++.++..++.+|..+...... ....+++.+...+.+ .+..++..++.+|..+... .. T Consensus 191 ~~l~~~l~~~~~~~~~~a~~~l~~~~~~~~~---~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~-~~--- 257 (373) T 5MU7_A 191 GTVFEGIPNAEELLQLVEIEFIRKDALHNPQ---NKPRYLRLIFDLLEA------NTSTVVYEAASSLTALTNN-PV--- 257 (373) T ss_dssp HHTGGGGGGSCHHHHHHHHHHHHHHHHHCGG---GHHHHHHHHHHHTTC------SSHHHHHHHHHHHHHHCCC-HH--- T ss_pred HHHHhcCCChhHHHHHHHHHHHHHHhccCcc---cHHHHHHHHHHHHhc------CCHHHHHHHHHHHHHcCCC-HH--- Confidence 3344444444444444455444444332100 012344555555544 2556677777777776542 11 Q NP_000290.2 678 QYFSSSMLNNIINLCR-SSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 678 ~Lve~giL~~Ll~LL~-s~~d~eVr~aAL~aLsnL~~~ 714 (747) .. ...++.+...+. +. ++.++..++.+|..+... T Consensus 258 -~~-~~~~~~l~~~l~~~~-~~~vr~~a~~~l~~l~~~ 292 (373) T 5MU7_A 258 -AV-KAAAGKFIELAIKEA-DNNVKLIVLDRVDQLRQK 292 (373) T ss_dssp -HH-HHHHHHHHHHHHHCC-CHHHHHHHHHHHHHHHHH T ss_pred -HH-HHHHHHHHHHHhhCC-ChhHHHHHHHHHHHHHHh Confidence 11 135666777776 44 778888888888888865 No 357 >4UQI_B AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ENDOCYTOSIS, PROTEIN TRANSPORT, LIPID BINDING; HET: IHP; 2.79A {RATTUS NORVEGICUS} Probab=84.97 E-value=0.056 Score=55.88 Aligned_cols=142 Identities=13% Similarity=0.105 Sum_probs=95.5 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+. ++++.++..++.++..+....+. . ...+++.+...+.+.++.++..++.+++.+..... T Consensus 50 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 118 (657) T 4UQI_B 50 LFPDVVNCMQ-TDNLELKKLVYLYLMNYAKSQPD--------M--AIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKI 118 (657) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCHh--------H--HHHHHHHHHHHhcCCCHHHHHHHHHHHhhcCCchh Confidence 4555666676 46677888888888887764221 1 13456667777777788889999999988864311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...+++.+...+.+ .++.++..++.+|..+....+.. +....+++.+..++.+. ++.++..++.+ T Consensus 119 -----~~~l~~~l~~~l~~------~~~~vr~~a~~~L~~l~~~~~~~---~~~~~~~~~l~~~l~d~-~~~vr~~a~~~ 183 (657) T 4UQI_B 119 -----TEYLCEPLRKCLKD------EDPYVRKTAAVCVAKLHDINAQM---VEDQGFLDSLRDLIADS-NPMVVANAVAA 183 (657) T ss_pred -----HHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCHHH---hcCcchHHHHHHHhcCC-CHHHHHHHHHH Confidence 12345556666655 36788899999999887643221 12234567777777766 77889999999 Q NP_000290.2 708 LSDMWSSK 715 (747) Q Consensus 708 LsnL~~~~ 715 (747) |..+.... T Consensus 184 l~~l~~~~ 191 (657) T 4UQI_B 184 LSEISESH 191 (657) T ss_pred HHHHHhcC Confidence 88887654 No 358 >6MZE_Z Tubulin alpha-1A chain, Tubulin beta; Microtubule, Tubulin, Tubulin polymerization, Heat; HET: MG, GTP, GDP; 3.6A {Sus scrofa} Probab=84.94 E-value=0.055 Score=53.37 Aligned_cols=149 Identities=8% Similarity=0.061 Sum_probs=96.3 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLM-GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 548 ~I~~LL~LL-~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) +++.+...+ . +.++.++..++.++..++..... . .... ....+++.+...+.+.+..++..++.+|..++... T Consensus 340 ~~~~l~~~l~~-d~~~~v~~~a~~~l~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~ 413 (536) T 6MZE_Z 340 YLRVLANVIQK-DANVQAVTIAANSVQLLCNSLRS---N-FTRS-YGAIVLVPLLERTKEKKPSVNEAICSALDAVATYC 413 (536) T ss_dssp THHHHHHHHHH-CSCHHHHHHHHHHHHHHHHHTTT---C-CSSH-HHHHHHHHHHHHTTCCCHHHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHHhc-CchHHHHHHHHHHHHHHHHHccc---c-ccHH-HHHHHHHHHHHHhhccCHHHHHHHHHHHHHHHHhc Confidence 556666776 5 46778888999999988764221 0 0101 12356677777777777788888988888887542 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA-------KQYFSSSMLNNIINLCRSSASPK 699 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~-------~~Lve~giL~~Ll~LL~s~~d~e 699 (747) .. ..+++.+...+.+ .++.++..++.+|..+........ ... ...+++.+...+.+. +.. T Consensus 414 ~~-----~~~~~~l~~~l~~------~~~~vr~~~l~~l~~~~~~~~~~~~~~~~~~~~~-~~~i~~~l~~~l~~~-~~~ 480 (536) T 6MZE_Z 414 GF-----DDCLEETLNYMKH------KTPQVRIECTKFLTRMLQGWKSDGPLQNQLLFKL-LPEVTTAVLKIVNDT-QPT 480 (536) T ss_dssp TT-----SSHHHHHHHHHTC------SSHHHHHHHHHHHHHHHHTCCCCSSSCCHHHHTC-CCCCCHHHHHHHTCS-SHH T ss_pred CH-----HHHHHHHHHHHcc------CCHHHHHHHHHHHHHHHhcCCCCCchhhHHHHHH-HHHHHHHHHHHHcCC-CHH Confidence 11 1244555555554 367788889999888876432210 011 123566677777765 778 Q NP_000290.2 700 AAEAARLLLSDMWSSK 715 (747) Q Consensus 700 Vr~aAL~aLsnL~~~~ 715 (747) ++..++.++..+.... T Consensus 481 vr~~a~~~l~~l~~~~ 496 (536) T 6MZE_Z 481 TRNTGFECFATLMKLV 496 (536) T ss_dssp HHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHH Confidence 9999999999888654 No 359 >4MFU_A Beta-catenin-like protein 1; ARM repeats, GENE REGULATION; 2.744A {Homo sapiens} Probab=84.81 E-value=0.067 Score=56.37 Aligned_cols=117 Identities=12% Similarity=0.116 Sum_probs=82.7 Template_Neff=8.700 Q NP_000290.2 610 DVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP---------QLAKQY 679 (747) Q Consensus 610 eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~---------e~~~~L 679 (747) .....++.+|.+|+..+.. ..++..++++.|+.+|.+ .+..+...++.+|.+|+.... .....+ T Consensus 42 ~~L~~ai~~L~~La~~p~~~~~lv~~g~i~~Lv~LL~~------~n~~i~~~a~~~L~~Lt~~~~~~~~~~~~~~~~~~l 115 (490) T 4MFU_A 42 LDLNDIIQEMHVVATMPDLYHLLVELNAVQSLLGLLGH------DNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDAL 115 (490) T ss_dssp HHHHHHHHHHHTTTTSCCCTHHHHHTTHHHHHHHHTSC------SSHHHHHHHHHHHHHHHHGGGSSCCCHHHHHHHHHH T ss_pred HHHHHHHHHHHHHhcCHHHHHHHHHCChHHHHHHHhCC------CCHHHHHHHHHHHHHHcCcccccCChhhHHHHHHHH Confidence 3445678888888876544 455667889999999976 356788899999999987532 235566 Q NP_000290.2 680 FSSSMLNNIINLCRS------SASPKAAEAARLLLSDMWSSK-ELQGVLRQQGFDRNMLGT 733 (747) Q Consensus 680 ve~giL~~Ll~LL~s------~~d~eVr~aAL~aLsnL~~~~-~~~~~~~~~~~~~~~~~~ 733 (747) .+.++++.|+.+|.. . +...+..++.+|.+|+... +....+.+.|+-..++.. T Consensus 116 ~~~g~l~~Lv~~L~~~~e~~~~-d~~~~~~al~~L~nL~~~~~~~~~~i~~~~~l~~Ll~~ 175 (490) T 4MFU_A 116 VDGQVVALLVQNLERLDESVKE-EADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKR 175 (490) T ss_dssp HHTTHHHHHHHHHHHCCTTCHH-HHHHHHHHHHHHHHHHHHSTTHHHHHCCCCCHHHHHHH T ss_pred HhCCHHHHHHHHHHhccccccc-hHHHHHHHHHHHHHHhccCHHHHHHHHHCCHHHHHHHH Confidence 677888889888875 3 5677889999999998754 444445555554444433 No 360 >5N3U_B Phycocyanobilin lyase subunit alpha (E.C.4.-.-.-); phycobilisome, chromophorylation, phycocyanin, lyase; 1.89A {Nostoc sp. PCC 7120} Probab=84.57 E-value=0.06 Score=46.12 Aligned_cols=135 Identities=14% Similarity=0.143 Sum_probs=82.4 Template_Neff=12.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) +.++.|...+. +.++.++..++.+|..+.. ..++.+...+.+.++.++..++.+|..+... T Consensus 32 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~-----------------~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~- 92 (208) T 5N3U_B 32 AAIPTLIAVFG-YNNPTAAAIASTALVQLGE-----------------VAVPQLLTQIDDYNYGARAYSIRTLAAIADP- 92 (208) T ss_dssp GGHHHHHHHTT-SCCHHHHHHHHHHHHHHGG-----------------GGHHHHHHCCCTTCHHHHHHHHHHHHHHCCG- T ss_pred hhHHHHHHHhC-CCCHHHHHHHHHHHHHhCc-----------------chHHHHHHHhhCCCHHHHHHHHHHHHHhcCc- Confidence 45666777776 3566677777776655432 1334455666667778888888888776522 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLA-KQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~-~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ..++.+...+... .++.++..++.+|..+........ ........++.+..++.+. ++.++..++ T Consensus 93 --------~~~~~l~~~l~~~-----~~~~vr~~a~~~l~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~vr~~a~ 158 (208) T 5N3U_B 93 --------RALDVLIDAAATD-----FAPSVRRAAAKGLGNLHWHKLEFPDNQTAPKKALETLLFISQDA-EWSIRYAAI 158 (208) T ss_dssp --------GGHHHHHHHHHHC-----CCHHHHHHHHHHHTTSCGGGSCTTHHHHHHHHHHHHHHHHTTCS-SHHHHHHHH T ss_pred --------chHHHHHHHHccC-----CCHHHHHHHHHHHHhhhccCCCCCCCccCChHHHHHHHHHhcCC-CHHHHHHHH Confidence 2344555555431 256788888888888864221111 1111123566666777665 677888888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..+... T Consensus 159 ~~l~~~~~~ 167 (208) T 5N3U_B 159 VGLQGLVNI 167 (208) T ss_dssp HHHHHGGGC T ss_pred HHHHHHcCC Confidence 888887764 No 361 >6QH5_B AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=84.43 E-value=0.06 Score=53.82 Aligned_cols=145 Identities=12% Similarity=0.031 Sum_probs=94.1 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.+|..+....+. ......+++.+...+.+.++.++..++.+|..+..... T Consensus 122 ~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~--------~~~~~~~~~~l~~~l~d~~~~vr~~a~~~l~~~~~~~~ 192 (592) T 6QH5_B 122 LCEPLRKCLK-DEDPYVRKTAAVCVAKLHDINAQ--------MVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHP 192 (592) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCch--------hhcCccHHHHHHHHhCCCCHHHHHHHHHHHHHHHhcCC Confidence 4566667776 46788889999999988764221 11224677788888888888899999999998886521 Q NP_000290.2 628 --LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 --~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ........+++.+...+.+ .++.++..++.+|..+....+.. ....++.+...+.+. ++.++..++ T Consensus 193 ~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~~~~~~~~~-----~~~~~~~l~~~l~~~-~~~vr~~a~ 260 (592) T 6QH5_B 193 NSNLLDLNPQNINKLLTALNE------CTEWGQIFILDCLSNYNPKDDRE-----AQSICERVTPRLSHA-NSAVVLSAV 260 (592) T ss_pred hhhhHhHHhhHHHHHHHHhcC------CCHHHHHHHHHHHHHHhcCCHHH-----HHHHHHHHHHHhcCC-CHHHHHHHH Confidence 1111122355566666654 25677778888888877542221 112455555666655 677888888 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .++..+.. T Consensus 261 ~~l~~l~~ 268 (592) T 6QH5_B 261 KVLMKFLE 268 (592) T ss_pred HHHHHHHh Confidence 88877763 No 362 >2DB0_A 253aa long hypothetical protein; HEAT repeats, helical structure, Structural; 2.2A {Pyrococcus horikoshii} Probab=84.35 E-value=0.062 Score=47.21 Aligned_cols=104 Identities=10% Similarity=0.179 Sum_probs=59.0 Template_Neff=12.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRH 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~ 625 (747) ..++.|+..+. +.++.++..++.+|..+...... . ...+++.+...+.+. ++.++..++.+|..+... T Consensus 32 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~~~~~ 100 (253) T 2DB0_A 32 SVLKKLIELLD-DDLWTVVKNAISIIMVIAKTRED--------L--YEPMLKKLFSLLKKSEAIPLTQEIAKAFGQMAKE 100 (253) T ss_dssp HHHHHHHHHTT-CSCHHHHHHHHHHHHHHHTTCGG--------G--HHHHHHHHHHHHHHCCSHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHcc-CCCHHHHHHHHHHHHHHHhhCHH--------H--HHHHHHHHHHHHhcCCChhHHHHHHHHHHHHHHh Confidence 45666777776 46677888888888777643110 0 122445566666666 677888888888777643 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) ... .+ ...++.+...+.+ .++.++..++.++..+.. T Consensus 101 ~~~--~~-~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~ 136 (253) T 2DB0_A 101 KPE--LV-KSMIPVLFANYRI------GDEKTKINVSYALEEIAK 136 (253) T ss_dssp CHH--HH-HHHHHHHHHHSCC------CSHHHHHHHHHHHHHHHH T ss_pred CHH--HH-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHH Confidence 110 00 1133444444444 245556666666665544 No 363 >2DB0_B 253aa long hypothetical protein; HEAT repeats, helical structure, Structural; 2.2A {Pyrococcus horikoshii} Probab=84.35 E-value=0.062 Score=47.21 Aligned_cols=104 Identities=10% Similarity=0.179 Sum_probs=59.0 Template_Neff=12.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRH 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~ 625 (747) ..++.|+..+. +.++.++..++.+|..+...... . ...+++.+...+.+. ++.++..++.+|..+... T Consensus 32 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~~~~~ 100 (253) T 2DB0_B 32 SVLKKLIELLD-DDLWTVVKNAISIIMVIAKTRED--------L--YEPMLKKLFSLLKKSEAIPLTQEIAKAFGQMAKE 100 (253) T ss_dssp HHHHHHHHHTT-CSSHHHHHHHHHHHHHHGGGCGG--------G--HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHcc-CCCHHHHHHHHHHHHHHHhhCHH--------H--HHHHHHHHHHHHhcCCChhHHHHHHHHHHHHHHh Confidence 45666777776 46677888888888777643110 0 122445566666666 677888888888777643 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) ... .+ ...++.+...+.+ .++.++..++.++..+.. T Consensus 101 ~~~--~~-~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~ 136 (253) T 2DB0_B 101 KPE--LV-KSMIPVLFANYRI------GDEKTKINVSYALEEIAK 136 (253) T ss_dssp CHH--HH-HHHHHHHTTTCCC------CSHHHHHHHHHHHHHHHH T ss_pred CHH--HH-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHH Confidence 110 00 1133444444444 245556666666665544 No 364 >2JKT_A AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ALTERNATIVE SPLICING, PHOSPHOPROTEIN, PHOSPHORYLATION, PROTEIN; HET: SEP, SO4; 3.4A {MUS MUSCULUS} Probab=84.21 E-value=0.064 Score=54.84 Aligned_cols=140 Identities=15% Similarity=0.148 Sum_probs=93.7 Template_Neff=12.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++.++. ++++.++..++.++..+...... . ...+++.+...+.+.++.++..++.+|..+..... T Consensus 75 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~al~~l~~~~~~~~ 143 (623) T 2JKT_A 75 GHMEAVNLLS-SNRYTEKQIGYLFISVLVNSNSE--------L--IRLINNAIKNDLASRNPTFMGLALHCIANVGSREM 143 (623) T ss_dssp CHHHHHHHTT-CSCHHHHHHHHHHHHHSCCCCHH--------H--HHHHHHHHHHHHHTTCHHHHHHHHHHHHHHCCHHH T ss_pred HHHHHHHHHc-CCCccHHHHHHHHHHHhcCCCHH--------H--HHHHHHHHHHHHhCCCHHHHHHHHHHHHhhCCHHH Confidence 4566777777 46778888888888887653221 1 12355667777777788899999999988764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+...+ .+ .++.++..++.+|..+....+.. +.....++.+..++.+. ++.++..++ T Consensus 144 -----~~~l~~~l~~~l~~~~------~~~~vr~~a~~~L~~~~~~~~~~---~~~~~~~~~l~~~l~~~-~~~vr~~a~ 208 (623) T 2JKT_A 144 -----AEAFAGEIPKILVAGD------TMDSVKQSAALCLLRLYRTSPDL---VPMGDWTSRVVHLLNDQ-HLGVVTAAT 208 (623) T ss_dssp -----HHHHTTHHHHHHHCTT------SCHHHHHHHHHHHHHHHHHCTTT---CCCCTHHHHHHGGGGCS-SHHHHHHHH T ss_pred -----HHHHHHhHHHHHHcCC------CCHHHHHHHHHHHHHHHHHChhh---cCccchHHHHHHHhcCC-CHHHHHHHH Confidence 112445556666 44 36788999999999887642221 11234567777777766 778888888 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .+|..+.. T Consensus 209 ~~l~~l~~ 216 (623) T 2JKT_A 209 SLITTLAQ 216 (623) T ss_dssp HHHHHHHT T ss_pred HHHHHHHH Confidence 88888775 No 365 >3LTJ_A AlphaRep-4; protein engineering, HEAT-like repeat, PROTEIN; 1.8A {synthetic} Probab=84.11 E-value=0.065 Score=45.71 Aligned_cols=28 Identities=11% Similarity=0.126 Sum_probs=18.0 Template_Neff=12.300 Q NP_000290.2 685 LNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 685 L~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) ++.+...+.+. +..++..++.++..+.. T Consensus 140 ~~~l~~~l~~~-~~~v~~~a~~~l~~~~~ 167 (201) T 3LTJ_A 140 VEPLIKALKDE-DGWVRQSAADALGEIGG 167 (201) T ss_dssp HHHHHHHTTCS-SHHHHHHHHHHHHHHCS T ss_pred HHHHHHHHhCC-ChHHHHHHHHHHHHhCc Confidence 44455555544 56777778888777664 No 366 >4P6Z_B BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=84.10 E-value=0.065 Score=53.98 Aligned_cols=145 Identities=12% Similarity=0.047 Sum_probs=94.3 Template_Neff=12.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) .++.+...+. +.++.++..++.+|..+....+. .+....+++.+...+.+.++.++..++.+|..+.... T Consensus 138 ~~~~l~~~l~-~~~~~vr~~a~~~L~~l~~~~~~--------~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 208 (600) T 4P6Z_B 138 LCEPLRKCLK-DEDPYVRKTAAVCVAKLHDINAQ--------LVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHP 208 (600) T ss_pred HHHHHHHhcC-CCCHHHHHHHHHHHHHHHhhChH--------HhhccChHHHHHHHhcCCCHHHHHHHHHHHHHHHhhCC Confidence 4566677776 46778888999999988764321 1112457778888888888899999999999888652 Q NP_000290.2 627 L-LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e-~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) . ........+++.+...+.+ .+..++..++.+|..+....+.. ....++.+...+.+. +..++..++ T Consensus 209 ~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~~~~~~~~~-----~~~~~~~l~~~l~~~-~~~vr~~a~ 276 (600) T 4P6Z_B 209 SSNLLDLNPQSINKLLTALNE------CTEWGQIFILDCLANYMPKDDRE-----AQSICERVTPRLSHA-NSAVVLSAV 276 (600) T ss_pred CcchhccCHHHHHHHHHHhhc------CCHHHHHHHHHHHHHhCCCCHHH-----HHHHHHHHHHHhcCC-CHHHHHHHH Confidence 1 1111122355556666654 25677778888888876542221 123455566666655 677788888 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .++..+.. T Consensus 277 ~~l~~l~~ 284 (600) T 4P6Z_B 277 KVLMKFME 284 (600) T ss_pred HHHHHHHH Confidence 88777764 No 367 >6QH7_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: SEP; 3.4A {Rattus norvegicus} Probab=84.02 E-value=0.067 Score=54.81 Aligned_cols=140 Identities=15% Similarity=0.148 Sum_probs=93.1 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++.++. ++++.++..++.++..+...... . ...+++.+...+.+.++.++..++.+|..+..... T Consensus 75 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~al~~l~~~~~~~~ 143 (621) T 6QH7_A 75 GHMEAVNLLS-SNRYTEKQIGYLFISVLVNSNSE--------L--IRLINNAIKNDLASRNPTFMGLALHCIANVGSREM 143 (621) T ss_dssp CHHHHHHHTT-CSSHHHHHHHHHHHHHSCCCCHH--------H--HHHHHHHHHHHHHSCCHHHHHHHHHHHHHHCCHHH T ss_pred HHHHHHHHHc-CCCccHHHHHHHHHHHHcCCCHH--------H--HHHHHHHHHHHHhcCCHHHHHHHHHHHHhhCCHHH Confidence 4556667776 46777888888888887754221 1 12345666677777788899999999988764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+...+ .+ .++.++..++.+|..+....+.. +.....++.+..++.+. ++.++..++ T Consensus 144 -----~~~l~~~l~~~l~~~~------~~~~vr~~a~~~L~~~~~~~~~~---~~~~~~~~~l~~~l~~~-~~~vr~~a~ 208 (621) T 6QH7_A 144 -----AEAFAGEIPKILVAGD------TMDSVKQSAALCLLRLYRTSPDL---VPMGDWTSRVVHLLNDQ-HLGVVTAAT 208 (621) T ss_dssp -----HHHHTTHHHHHHTTSC------CCHHHHHHHHHHHHHHHHHCGGG---CCCCTTHHHHHHGGGCS-SHHHHHHHH T ss_pred -----HHHHHhhHHHHHHcCC------CCHHHHHHHHHHHHHHHHHChhh---cCccchHHHHHHHhcCC-CHHHHHHHH Confidence 112445556666 44 36788999999999887643221 11234567777777765 778888888 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .+|..+.. T Consensus 209 ~~l~~l~~ 216 (621) T 6QH7_A 209 SLITTLAQ 216 (621) T ss_dssp HHHHHHHT T ss_pred HHHHHHHH Confidence 88888775 No 368 >6CRI_R Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=83.93 E-value=0.067 Score=53.93 Aligned_cols=67 Identities=18% Similarity=0.165 Sum_probs=49.2 Template_Neff=12.500 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) +++.+...+. +.++.++..++.+|..+....+. . ...+++.|...+.+.++.++..++.+|..+... T Consensus 135 ~~~~l~~~l~-~~~~~vr~~a~~~L~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 201 (585) T 6CRI_R 135 LAGEVEKLLK-TSNSYLRKKAALCAVHVIRKVPE--------L--MEMFLPATKNLLNEKNHGVLHTSVVLLTEMCER 201 (585) T ss_pred HHHHHHHHHh-CCChHHHHHHHHHHHHHHHHCHH--------H--HHHHHHHHHHHHcCCCHHHHHHHHHHHHHHHHh Confidence 4566777777 46778888999999888764221 1 135677788888878888999999999888754 No 369 >4UQI_B AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ENDOCYTOSIS, PROTEIN TRANSPORT, LIPID BINDING; HET: IHP; 2.79A {RATTUS NORVEGICUS} Probab=83.87 E-value=0.069 Score=55.16 Aligned_cols=145 Identities=12% Similarity=0.031 Sum_probs=94.3 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.+|..+....+. .+....+++.+..++.+.++.++..++.+|..+..... T Consensus 122 l~~~l~~~l~-~~~~~vr~~a~~~L~~l~~~~~~--------~~~~~~~~~~l~~~l~d~~~~vr~~a~~~l~~l~~~~~ 192 (657) T 4UQI_B 122 LCEPLRKCLK-DEDPYVRKTAAVCVAKLHDINAQ--------MVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHP 192 (657) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCHH--------HhcCcchHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCC Confidence 4566667776 46778888999999988764321 11224677788888888888899999999999887521 Q NP_000290.2 628 --LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 --~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ........+++.+...+.+ .++.++..++.+|..+....... ...+++.+...+.+. +..++..++ T Consensus 193 ~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~L~~l~~~~~~~-----~~~~~~~l~~~l~~~-~~~vr~~a~ 260 (657) T 4UQI_B 193 NSNLLDLNPQNINKLLTALNE------CTEWGQIFILDCLSNYNPKDDRE-----AQSICERVTPRLSHA-NSAVVLSAV 260 (657) T ss_pred hhhhhhhhhcHHHHHHHHhcC------CCHHHHHHHHHHHHhhCCCCHHH-----HHHHHHHHHHHhcCC-CHHHHHHHH Confidence 1111123355666666655 35677888888888887542221 112455566666555 667777777 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .++..+.. T Consensus 261 ~~l~~l~~ 268 (657) T 4UQI_B 261 KVLMKFLE 268 (657) T ss_pred HHHHHHHh Confidence 77777663 No 370 >5XAH_A Importin-4; Histone, Chromatin, Assembly, PROTEIN TRANSPORT; HET: MSE; 3.004A {Homo sapiens} Probab=83.55 E-value=0.071 Score=50.49 Aligned_cols=142 Identities=14% Similarity=0.108 Sum_probs=83.6 Template_Neff=12.900 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRHP-LLHRVMGNQVFP 638 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~~-e~~~ll~~giI~ 638 (747) ++.++..++.++..++..... . ....+ -..+++.+...+.+. +..++..++.++..++... .........+++ T Consensus 163 ~~~v~~~a~~~l~~l~~~~~~---~-~~~~~-~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~ 237 (416) T 5XAH_A 163 DAMLLEHAGEAIPALAAAAGG---D-SFAPF-FAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLP 237 (416) T ss_dssp HHHHHHHHHHHHHHHHHHHTS---T-TTHHH-HHHHHHHHHHTTSSSSCHHHHHHHHHHHHHHHHHHGGGGGGGHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHhCc---c-chHHH-HHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHH Confidence 455667778888777654210 0 01111 133556666666543 3567778888888877541 111111123566 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR-SSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~-s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .+...+.+ .++.++..++.+|..++...+......+ ..+++.+...+. +. ++.++..++.++..++... T Consensus 238 ~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~-~~i~~~l~~~l~~~~-~~~v~~~a~~~l~~l~~~~ 307 (416) T 5XAH_A 238 VLLSTAQE------ADPEVRSNAIFGMGVLAEHGGHPAQEHF-PKLLGLLFPLLARER-HDRVRDNICGALARLLMAS 307 (416) T ss_dssp HHHHHTSC------SSHHHHHHHHHHHHHHHHHHHHHHHTTH-HHHHHHHTTHHHHCC-CHHHHHHHHHHHHHHHHHC T ss_pred HHHHHhhc------CCHHHHHHHHHHHHHHHHhcCchHHhhH-HHHHHHHHHHhccCC-CHHHHHHHHHHHHHHHHhC Confidence 66666655 3678889999999998865332222222 235666777776 44 6778888888888877543 No 371 >5XAH_C Importin-4; Histone, Chromatin, Assembly, PROTEIN TRANSPORT; HET: MSE; 3.004A {Homo sapiens} Probab=83.55 E-value=0.071 Score=50.49 Aligned_cols=142 Identities=14% Similarity=0.108 Sum_probs=83.6 Template_Neff=12.900 Q NP_000290.2 561 KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG-NSDVVRSGASLLSNMSRHP-LLHRVMGNQVFP 638 (747) Q Consensus 561 d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~-d~eVr~~AL~aLsnLa~~~-e~~~ll~~giI~ 638 (747) ++.++..++.++..++..... . ....+ -..+++.+...+.+. +..++..++.++..++... .........+++ T Consensus 163 ~~~v~~~a~~~l~~l~~~~~~---~-~~~~~-~~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~ 237 (416) T 5XAH_C 163 DAMLLEHAGEAIPALAAAAGG---D-SFAPF-FAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLP 237 (416) T ss_dssp HHHHHHHHHTHHHHHHHHHTS---T-TTHHH-HHHHHHHHHHTTSTTSCHHHHHHHHHHHHHHHHHHGGGGGGGHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHhCc---c-chHHH-HHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHH Confidence 455667778888777654210 0 01111 133556666666543 3567778888888877541 111111123566 Q NP_000290.2 639 EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR-SSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 639 ~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~-s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .+...+.+ .++.++..++.+|..++...+......+ ..+++.+...+. +. ++.++..++.++..++... T Consensus 238 ~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~-~~i~~~l~~~l~~~~-~~~v~~~a~~~l~~l~~~~ 307 (416) T 5XAH_C 238 VLLSTAQE------ADPEVRSNAIFGMGVLAEHGGHPAQEHF-PKLLGLLFPLLARER-HDRVRDNICGALARLLMAS 307 (416) T ss_dssp HHHHHTTC------SSHHHHHHHHHHHHHHHHHSHHHHHTTH-HHHHHHHTHHHHHCC-CHHHHHHHHHHHHHHHHTS T ss_pred HHHHHhhc------CCHHHHHHHHHHHHHHHHhcCchHHhhH-HHHHHHHHHHhccCC-CHHHHHHHHHHHHHHHHhC Confidence 66666655 3678889999999998865332222222 235666777776 44 6778888888888877543 No 372 >5FRS_A SISTER CHROMATID COHESION PROTEIN PDS5; COHESIN, DNA REPLICATION, SISTER CHROMATID; 4.073A {SACCHAROMYCES CEREVISIAE} Probab=83.54 E-value=0.08 Score=57.55 Aligned_cols=149 Identities=7% Similarity=0.080 Sum_probs=99.5 Template_Neff=9.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) +++.|...+. +.++.++..|+.+|..+....+. . .... ....+++.++..+.+.++.++..++.++..+... + T Consensus 282 vl~~L~~~l~-~~~~~vR~~A~~~L~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~d~~~~vR~~a~~~l~~~~~~~~ 355 (703) T 5FRS_A 282 VIGFIYHELS-SENELFRKEATKLIGQILTSYSD---L-NFVS-THSDTFKAWISKIADISPDVRVEWTESIPQIIATRE 355 (703) T ss_pred hHHHHHHHhc-CCCHHHHHHHHHHHHHHhCCCCc---c-cHHH-HchhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHhCH Confidence 5666666676 46778899999999988764221 0 0011 1245667777777778889999999999988764 2 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .. ...+++.+...+.+ .++.++..|+.+|+.+..... .........++.+...+.+. +..++..|+. T Consensus 356 ~~----~~~i~~~l~~~l~D------~d~~VR~~A~~~L~~~~~~~~--~~~~~~~~~l~~l~~~l~d~-~~~VR~~A~~ 422 (703) T 5FRS_A 356 DI----SKELNQALAKTFID------SDPRVRRTSVMIFNKVPVTEI--WKNITNKAIYTSLLHLAREK-HKEVRELCIN 422 (703) T ss_pred HH----HHHHHHHHHHHhcC------CCHHHHHHHHHHHHhhcccCc--cccCCCcccHHHHHHHhcCC-CHHHHHHHHH Confidence 11 22356666666666 478999999999998865321 00111234567777777766 7789999999 Q NP_000290.2 707 LLSDMWSSK 715 (747) Q Consensus 707 aLsnL~~~~ 715 (747) +|..+.... T Consensus 423 ~L~~l~~~~ 431 (703) T 5FRS_A 423 TMAKFYSNS 431 (703) T ss_pred HHHHHHHhC Confidence 888777543 No 373 >4HM9_A Beta-catenin-like protein 1; all alpha-helical, armadillo repeats, PROTEIN; 3.1001A {Homo sapiens} Probab=83.50 E-value=0.087 Score=56.79 Aligned_cols=136 Identities=13% Similarity=0.067 Sum_probs=87.4 Template_Neff=8.100 Q NP_000290.2 246 TIPKAVQYLSS------QDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP--NQNVQQAAAGALRNLVFR 317 (747) Q Consensus 246 iL~~Ll~lL~s------sd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~--d~eVr~~AL~aLs~La~~ 317 (747) +++.|+..+.. .+...+..++.+|.+++...+.....+...++++.|+.++... ....+..+..+|..++.. T Consensus 198 ~l~~Lv~~L~~l~e~~~~d~~~~~~al~iL~nL~~~~~~~~~~i~~~g~l~~Ll~lL~~~~~~~~~k~~AaeiL~~L~~~ 277 (568) T 4HM9_A 198 VVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKMPFDANKLYCSEVLAILLQD 277 (568) T ss_dssp HHHHHHHHHTTCCTTSHHHHHHHHHHHHHHHHHHHHCGGGHHHHCCCCCHHHHHHHHHSSCCCCHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHHhcccccccchHHHHHHHHHHHHHHhccCHHHHHHHHHCCHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcC Confidence 44555555554 4556778888999988865433333344456788888888764 466788889999988865 Q NP_000290.2 318 STTNKLETRRQNGIREAVSLLRR-----TG---NAEIQKQLTGLLWNLSSTDELKEELIA-DALPVLADRVII 381 (747) Q Consensus 318 ~~~~~~~ll~~~IL~~Ll~lL~s-----s~---d~eVr~~AL~aLsnLas~~~~~~~Lve-giLe~Lv~LL~~ 381 (747) .......+...+.++.|+.++.. .. .......++.+|..++........++. ++++.|+.+|+. T Consensus 278 ~~~~r~~l~~~g~I~~LL~lL~~y~~~d~~~~~e~e~~en~~~aL~~L~~~~~~r~~f~~~~gv~lLv~lL~~ 350 (568) T 4HM9_A 278 NDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLRE 350 (568) T ss_dssp CHHHHHHHHHTTHHHHHHHHHGGGTTSCCSSSHHHHHHHHHHHHHHHHTTSTHHHHHHHHTTHHHHHHHHHHH T ss_pred CHHHHHHHHhCchHHHHHHHHHhhhccCCCCHHHHHHHHHHHHHHHHHhCCHHHHHHHHHCChHHHHHHHHhC Confidence 44444444445677777777731 11 123444557788887766555555555 778888888875 No 374 >5FRP_A SISTER CHROMATID COHESION PROTEIN PDS5; CELL CYCLE, CELL DIVISION, COHESIN; 2.895A {SACCHAROMYCES CEREVISIAE} Probab=83.43 E-value=0.082 Score=57.48 Aligned_cols=149 Identities=7% Similarity=0.080 Sum_probs=99.6 Template_Neff=9.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) +++.|...+. +.++.++..|+.+|..+....+. . .... ....+++.++..+.+.++.++..++.++..+... + T Consensus 282 vl~~L~~~l~-~~~~~vR~~A~~~L~~l~~~~~~---~-~~~~-~~~~~~~~l~~~l~d~~~~vR~~a~~~l~~~~~~~~ 355 (703) T 5FRP_A 282 VIGFIYHELS-SENELFRKEATKLIGQILTSYSD---L-NFVS-THSDTFKAWISKIADISPDVRVEWTESIPQIIATRE 355 (703) T ss_dssp THHHHHHHHT-CSSHHHHHHHHHHHHHHTTSCCS---S-CHHH-HTHHHHHHHHGGGGCSSHHHHHHHHHTHHHHHHHCC T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCCC---c-CHHH-HCHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHcCH Confidence 5666666676 46778899999999988764221 0 0011 1245667777777778889999999999988764 2 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .. ...+++.+...+.+ .++.++..|+.+|+.+..... .........++.+...+.+. +..++..|+. T Consensus 356 ~~----~~~i~~~l~~~l~D------~d~~VR~~A~~~L~~~~~~~~--~~~~~~~~~l~~l~~~l~d~-~~~VR~~A~~ 422 (703) T 5FRP_A 356 DI----SKELNQALAKTFID------SDPRVRRTSVMIFNKVPVTEI--WKNITNKAIYTSLLHLAREK-HKEVRELCIN 422 (703) T ss_dssp SC----SSHHHHHHHHHTTC------SSHHHHHHHHHHHHHSCHHHH--HHHCCCHHHHHHHHHGGGBS-CHHHHHHHHH T ss_pred HH----HHHHHHHHHHHhcC------CCHHHHHHHHHHHhhcChhHH--hhcCCchHHHHHHHHHHhcC-CHHHHHHHHH Confidence 11 22356666677666 478999999999998865311 00111234567777777766 7789999999 Q NP_000290.2 707 LLSDMWSSK 715 (747) Q Consensus 707 aLsnL~~~~ 715 (747) +|..+.... T Consensus 423 ~L~~l~~~~ 431 (703) T 5FRP_A 423 TMAKFYSNS 431 (703) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHH Confidence 888777543 No 375 >5GM6_G Prp8, Brr2, Snu114, Rse1, Cus1; spliceosome, RNA splicing, Bact, Catalytically; HET: GTP, ADP, ZN; 3.5A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=83.42 E-value=0.077 Score=58.66 Aligned_cols=69 Identities=9% Similarity=-0.111 Sum_probs=31.7 Template_Neff=11.400 Q NP_000290.2 248 PKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVF 316 (747) Q Consensus 248 ~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~ 316 (747) +.+...+.+.++.++..++.++..+...............+++.+...+.+.+..++..++.++..++. T Consensus 603 ~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~l~~~l~~~l~~~~~~v~~~a~~~l~~l~~ 671 (971) T 5GM6_G 603 STILNHLKHKTPLVRQHAADLCAILIPVIKNCHEFEMLNKLNIILYESLGEVYPEVLGSIINAMYCITS 671 (971) T ss_pred HHHHHHhcCCCHHHHHHHHHHHHHHHHHHhhcchHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHh Confidence 333344444455566666665555543211111100111234444444444445566666666666554 No 376 >5ZWM_1 Pre-mRNA-splicing factor 8, U4/U6 small; spliceosome, assembly, pre-B complex, U1; HET: GTP; 3.4A {Saccharomyces cerevisiae S288c} Probab=83.42 E-value=0.077 Score=58.66 Aligned_cols=69 Identities=9% Similarity=-0.111 Sum_probs=31.7 Template_Neff=11.400 Q NP_000290.2 248 PKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVF 316 (747) Q Consensus 248 ~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~ 316 (747) +.+...+.+.++.++..++.++..+...............+++.+...+.+.+..++..++.++..++. T Consensus 603 ~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~l~~~l~~~l~~~~~~v~~~a~~~l~~l~~ 671 (971) T 5ZWM_1 603 STILNHLKHKTPLVRQHAADLCAILIPVIKNCHEFEMLNKLNIILYESLGEVYPEVLGSIINAMYCITS 671 (971) T ss_dssp HHHHHHTTCSSHHHHHHHHHHHHHHHHHHHHTTCHHHHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHHH T ss_pred HHHHHHhcCCCHHHHHHHHHHHHHHHHHHhhcchHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHh Confidence 333344444455566666665555543211111100111234444444444445566666666666554 No 377 >3TJZ_B ADP-ribosylation factor 1, Coatomer subunit; protein trafficking, Golgi membrane, protein; HET: GNP; 2.9A {Saccharomyces cerevisiae} Probab=83.38 E-value=0.075 Score=50.15 Aligned_cols=102 Identities=16% Similarity=0.082 Sum_probs=56.5 Template_Neff=12.100 Q NP_000290.2 596 GLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL 675 (747) Q Consensus 596 iI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~ 675 (747) .++.+..++.+.+..++..++.+|..+...... ....+++.+..++.+ .++.++..++.+|..+....+.. T Consensus 251 ~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~---~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~ 321 (355) T 3TJZ_B 251 LFDFIESCLRNKHEMVVYEAASAIVNLPGCSAK---ELAPAVSVLQLFCSS------PKAALRYAAVRTLNKVAMKHPSA 321 (355) T ss_pred HHHHHHHHhCCCCHHHHHHHHHHHHHHccCCHH---HHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHcCHHH Confidence 445555556555666666666666666543100 001233444444444 25667777778877776532211 Q NP_000290.2 676 AKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMW 712 (747) Q Consensus 676 ~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~ 712 (747) . ...++.+..++.+. +..++..|+.+|..+. T Consensus 322 ~-----~~~~~~l~~~l~~~-~~~vr~~a~~~L~~l~ 352 (355) T 3TJZ_B 322 V-----TACNLDLENLVTDA-NRSIATLAITTLLKTG 352 (355) T ss_pred H-----HHHHHHHHHHhcCC-CHHHHHHHHHHHHHhh Confidence 1 12335566666655 6677888888777764 No 378 >6CRI_R Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=83.30 E-value=0.075 Score=53.54 Aligned_cols=101 Identities=12% Similarity=0.040 Sum_probs=51.9 Template_Neff=12.500 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.++.++..++..+..+.... ....+++.+...+.+.++.++..++.++..+....+... T Consensus 100 ~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~-------~~~~~~~~l~~~l~~~~~~vr~~a~~~L~~~~~~~~~~~--- 169 (585) T 6CRI_R 100 MTNCIKNDLNHSTQFVQGLALCTLGCMGSSE-------MCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELM--- 169 (585) T ss_pred HHHHHHHHhcCCCHHHHHHHHHHHHhhCCHH-------HHHHHHHHHHHHHhCCChHHHHHHHHHHHHHHHHCHHHH--- Confidence 4444444555555566666666665554211 011234445555555556666666666666654322111 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ..+++.+...+. +.++.++..++.++..+.. T Consensus 170 --~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~ 200 (585) T 6CRI_R 170 --EMFLPATKNLLN-EKNHGVLHTSVVLLTEMCE 200 (585) T ss_pred --HHHHHHHHHHHc-CCCHHHHHHHHHHHHHHHH Confidence 234445555554 4455666666666666654 No 379 >6U62_A Regulatory-associated protein of mTOR, Ras-related; signaling complex, GTPase, lysosome, SIGNALING; HET: GDP, GTP;{Homo sapiens} Probab=83.02 E-value=0.095 Score=62.46 Aligned_cols=159 Identities=10% Similarity=0.013 Sum_probs=98.7 Template_Neff=8.000 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSN 621 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsn 621 (747) ...|+++.++++|++ ...+.+...+.+...++.-+.. ....+++.+....++.+|.... +..+..++.+|+. T Consensus 468 l~~gifp~~~~ll~~-~~~~~~~~l~~iw~kil~~d~~-----~~~~l~~~~~~~~f~~~l~~~~~~~~~~~~~afiLa~ 541 (1392) T 6U62_A 468 LSVGIFPYVLKLLQS-SARELRPLLVFIWAKILAVDSS-----CQADLVKDNGHKYFLSVLADPYMPAEHRTMTAFILAV 541 (1392) T ss_dssp HHHTCHHHHHHGGGC-CCSTTHHHHHHHHHHHHTTCGG-----GHHHHHHTTTHHHHHHHHHSTTSCSSSHHHHHHHHHH T ss_pred HHcCcHHHHHHHHHc-cchhhHHHHHHHHHHHHhhCch-----hHHHHHhccchHHHHHhhcCCCCChhHHHHHHHHHHH Confidence 466778888888873 4445554445555555443221 1222234444555666665432 2244566667777 Q NP_000290.2 622 MSRH-PLLH-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPK 699 (747) Q Consensus 622 La~~-~e~~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~e 699 (747) ++.. .... .....+++..+...|.. .++.++..++-+|+.|....+..+...+..+....|..++.+. .++ T Consensus 542 ~~~~~~~~q~~~~~~~~~~~~~~~l~~------~~~~~r~W~~l~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~d~-~pe 614 (1392) T 6U62_A 542 IVNSYHTGQEACLQGNLIAICLEQLND------PHPLLRQWVAICLGRIWQNFDSARWCGVRDSAHEKLYSLLSDP-IPE 614 (1392) T ss_dssp HSTTCHHHHHHHHHTTHHHHHHTSTTC------SCHHHHHHHHHHHHHHSSSCHHHHHHHHTTTHHHHSGGGGGCS-STT T ss_pred HHhhCcchHHHHHhchHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCHHHHHHhhcccHHHHHHHHhcCC-CHH Confidence 7754 2222 22233455666666654 3688899999999999876555555555555667788888877 899 Q NP_000290.2 700 AAEAARLLLSDMWSSK 715 (747) Q Consensus 700 Vr~aAL~aLsnL~~~~ 715 (747) ||.+|+.+|+.++... T Consensus 615 VRaaav~aL~~~i~~~ 630 (1392) T 6U62_A 615 VRCAAVFALGTFVGNS 630 (1392) T ss_dssp HHHHHHHHHHHHSCCT T ss_pred HHHHHHHHHHHhhCCC Confidence 9999999998887553 No 380 >6BCX_W mTOR, Target of rapamycin complex; PIKK, TRANSFERASE; HET: ATP; 3.0A {Homo sapiens} Probab=82.82 E-value=0.098 Score=62.11 Aligned_cols=159 Identities=10% Similarity=0.013 Sum_probs=98.0 Template_Neff=7.900 Q NP_000290.2 544 YHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSN 621 (747) Q Consensus 544 ve~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsn 621 (747) ...|+++.++++|++ ...+.+...+.+...++.-+.. ....+++.+....++.+|.... +..+..++.+|+. T Consensus 476 l~~gifp~~~~ll~~-~~~~~~~~l~~iw~kil~~d~~-----~~~~l~~~~~~~~f~~~l~~~~~~~~~~~~~a~iLa~ 549 (1343) T 6BCX_W 476 LSVGIFPYVLKLLQS-SARELRPLLVFIWAKILAVDSS-----CQADLVKDNGHKYFLSVLADPYMPAEHRTMTAFILAV 549 (1343) T ss_dssp HHHTCHHHHHHGGGC-CCGGGHHHHHHHHHHHHHHCGG-----GHHHHHHTTHHHHHHHHHTCTTSCHHHHHHHHHHHHH T ss_pred HHcCcHHHHHHHHHc-cchhhHHHHHHHHHHHHhhCcc-----hHHHHHhccchhHHHHhhcCCCCChhHHHHHHHHHHH Confidence 356778888888873 4444544444455555443221 1222234444555666665432 2234566667777 Q NP_000290.2 622 MSRH-PLLH-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPK 699 (747) Q Consensus 622 La~~-~e~~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~e 699 (747) ++.. .... .....+++..+...|.. .++.++..++-+|+.|....+..+...+..+....+..++.+. .++ T Consensus 550 ~~~~~~~~q~~~~~~~~~~~~~~~l~~------~~~~~r~W~~l~l~~l~~~~~~~~~~~~~~~~~~~~~~~l~d~-~pe 622 (1343) T 6BCX_W 550 IVNSYHTGQEACLQGNLIAICLEQLND------PHPLLRQWVAICLGRIWQNFDSARWCGVRDSAHEKLYSLLSDP-IPE 622 (1343) T ss_dssp HSTTCHHHHHHHHHTTHHHHHHHTTTC------SCHHHHHHHHHHHHHHTTTCHHHHHHHHHHTHHHHHGGGGGCS-SHH T ss_pred HHhhCchhHHHHHhchHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCHHHHHHhhcccHHHHHHHHhcCC-CHH Confidence 7654 2222 22333456666666654 3688899999999999876555555555555667788888877 899 Q NP_000290.2 700 AAEAARLLLSDMWSSK 715 (747) Q Consensus 700 Vr~aAL~aLsnL~~~~ 715 (747) ||.+++.+|+.++... T Consensus 623 vRaa~v~aL~~~i~~~ 638 (1343) T 6BCX_W 623 VRCAAVFALGTFVGNS 638 (1343) T ss_dssp HHHHHHHHHHHHHTTC T ss_pred HHHHHHHHHHHhhCCC Confidence 9999999998887653 No 381 >4QMH_A LP04448p; PROTEIN BINDING, TOG DOMAIN; 1.652A {Drosophila melanogaster} Probab=82.76 E-value=0.081 Score=45.96 Aligned_cols=114 Identities=8% Similarity=0.065 Sum_probs=67.9 Template_Neff=12.700 Q NP_000290.2 595 KGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ 674 (747) Q Consensus 595 giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e 674 (747) .+++.+...+.+.++.++..++.+|..+.............+++.+...+.+ .++.++..++.++..++..... T Consensus 17 ~l~~~l~~~l~~~~~~~r~~a~~~l~~~~~~~~~~~~~~~~~~~~l~~~l~d------~~~~v~~~a~~~l~~l~~~~~~ 90 (241) T 4QMH_A 17 QITEALLKEMSDKDWKTRNEGLTKLQAIISEARLIKPSIGDLAPALAHRLVD------SNAKIAQTTLAICEQLATAMGA 90 (241) T ss_dssp GSCHHHHHHHTCSSHHHHHHHHHHHHHHHHHHCSBCSCCTTHHHHHHHHHTC------SSHHHHHHHHHHHHHHHHHHGG T ss_pred HhhHHHHHhcCCccHHHHHHHHHHHHHHHHhCCcCcccHHHHHHHHHHHHcC------CCHHHHHHHHHHHHHHHHHhcH Confidence 3455566666677778888888888888764211110112345555666655 3678888888888888764322 Q NP_000290.2 675 LAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 675 ~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) ...... ..+++.+...+.+. +..++..++.+|..+..... T Consensus 91 ~~~~~~-~~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~~~~~ 130 (241) T 4QMH_A 91 GCRNHV-RNLFPGFLHALGDN-KSFVRAAALNCINSFGEKGG 130 (241) T ss_dssp GGGGGH-HHHHHHHHHHTTCS-SHHHHHHHHHHHHHHHHHHC T ss_pred HHHHHH-HHHHHHHHHHhcCC-cHHHHHHHHHHHHHHHHhcC Confidence 111111 23455666666554 55677777777777665443 No 382 >6QH5_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=82.76 E-value=0.083 Score=54.05 Aligned_cols=140 Identities=15% Similarity=0.148 Sum_probs=92.9 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.++..+. +.+..++..++.++..+...... . ...+++.+...+.+.++.++..++.+|..+..... T Consensus 75 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~al~~l~~~~~~~~ 143 (621) T 6QH5_A 75 GHMEAVNLLS-SNRYTEKQIGYLFISVLVNSNSE--------L--IRLINNAIKNDLASRNPTFMGLALHCIANVGSREM 143 (621) T ss_pred hHHHHHHHhc-CCCHHHHHHHHHHHHHHhhcCHH--------H--HHHHHHHHHHHhcCCCHHHHHHHHHHHHHhcCHHH Confidence 4556667776 46677888888888887653221 1 12355666777777788899999999888764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+...+ .+ .++.++..++.+|..+....+.. +.....++.+..++.+. ++.++..++ T Consensus 144 -----~~~l~~~l~~~l~~~~------~~~~vr~~a~~~L~~l~~~~~~~---~~~~~~~~~l~~~l~~~-~~~vr~~a~ 208 (621) T 6QH5_A 144 -----AEAFAGEIPKILVAGD------TMDSVKQSAALCLLRLYRTSPDL---VPMGDWTSRVVHLLNDQ-HLGVVTAAT 208 (621) T ss_pred -----HHHHHHHHHHHhcCCC------CCHHHHHHHHHHHHHHHHhChHH---ccHHHHHHHHHHHhcCC-CHHHHHHHH Confidence 112445555666 44 36788999999999887642221 11234567777777766 778888888 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .+|..+.. T Consensus 209 ~~L~~l~~ 216 (621) T 6QH5_A 209 SLITTLAQ 216 (621) T ss_pred HHHHHHHH Confidence 88888775 No 383 >6EMK_C Serine/threonine-protein kinase TOR2 (E.C.2.7.1.67,2.7.11.1), Target; target of rapamycin, torc2, FRB; 8.0A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=82.75 E-value=0.086 Score=64.86 Aligned_cols=71 Identities=13% Similarity=0.124 Sum_probs=44.6 Template_Neff=11.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLE-ACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~-~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) +++.|+..+. +.+..++. .++.+|..++..... ....+ -..+++.+...+.+.+..++..++.+|..++.. T Consensus 922 ~~~~L~~~l~-d~~~~v~~~~a~~~L~~i~~~~~~-----~~~~~-l~~l~~~l~~~l~~~~~~vr~~~~~~L~~l~~~ 993 (2474) T 6EMK_C 922 VIHNLMKILN-DPSLSIHHTAAIQAIMHIFQNLGL-----RCVSF-LDQIIPGIILVMRSCPPSQLDFYFQQLGSLISI 993 (2474) T ss_dssp TTCCCCCCTT-CCCCCCCCCCCTTTCCCCCCCCCC-----CCCCC-SSTTCCCCCCCCCCCCHHHHCCCCCCTTTCCCC T ss_pred HHHHHHHHHc-CCchHHHHHHHHHHHHHHHHHcch-----hhHHh-HhhHHHHHHHHHhhCCHHHHHHHHHHHHHHHHH Confidence 4566667776 34555555 778888887764221 01111 134566677777666677888888888888764 No 384 >5MU7_A Coatomer subunit beta, Coatomer subunit; coatomer, COPI, beta COP, delta; 2.57A {Chaetomium thermophilum var. thermophilum DSM 1495} Probab=82.68 E-value=0.082 Score=49.28 Aligned_cols=71 Identities=11% Similarity=-0.055 Sum_probs=38.3 Template_Neff=12.800 Q NP_000290.2 548 AIRTYLNLM-GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 548 ~I~~LL~LL-~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) .++.++..+ . ++++.++..++.+|..+...... . .... .....++.+...+.+.++.++..++.+|..+.. T Consensus 39 ~~~~l~~~l~~-~~~~~~r~~a~~~l~~~~~~~~~---~-~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~ 110 (373) T 5MU7_A 39 LLMHIIRFVMP-SKSKPLKKLLYFYYEICPKLDSQ---G-KLKQ-EFILVCNGIRNDLQHPNEYIRGNTLRFLCKLRE 110 (373) T ss_dssp GHHHHHHHTTT-CCCHHHHHHHHHHHHHSCCBCTT---S-CBCT-HHHHHHHHHHHHTTCSSHHHHHHHHHHHTTCCC T ss_pred HHHHHHHHHcC-CCChhhHHHHHHHHHhccccCCc---c-hHHH-HHHHHHHHHHHHccCCCHHHHHHHHHHHHhccC Confidence 345555553 4 35666777777777776542111 0 0000 012345556666666666777777777766543 No 385 >6CRI_I Bone marrow stromal antigen 2,Nef; AP, HIV, Nef, trafficking, VIRAL; HET: GTP;{Homo sapiens} Probab=82.65 E-value=0.081 Score=52.06 Aligned_cols=145 Identities=12% Similarity=0.047 Sum_probs=93.3 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) .++.+...+. +.++.++..++.+|..+...... .....++++.+...+.+.++.++..++.+|..+.... T Consensus 109 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~--------~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~ 179 (570) T 6CRI_I 109 LCEPLRKCLK-DEDPYVRKTAAVCVAKLHDINAQ--------LVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHP 179 (570) T ss_dssp SHHHHHHHHT-CSSHHHHHHHHHHHHHHHHHCHH--------HHHHHTHHHHHHHHHTSSSHHHHHHHHHHHHHHHHHTT T ss_pred HHHHHHHhcC-CCCHHHHHHHHHHHHHHHHhChh--------hhhccchHHHHHHHhcCCCHHHHHHHHHHHHHHHhhCC Confidence 4556667776 46778888999999988764321 1112456778888888888899999999999888652 Q NP_000290.2 627 L-LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e-~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) . ........+++.+...+.+ .++.++..++.+|..+....... ....++.+...+.+. ++.++..++ T Consensus 180 ~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~~~~~~~~~-----~~~~~~~l~~~l~~~-~~~vr~~a~ 247 (570) T 6CRI_I 180 SSNLLDLNPQSINKLLTALNE------CTEWGQIFILDCLANYMPKDDRE-----AQSICERVTPRLSHA-NSAVVLSAV 247 (570) T ss_dssp STTCCCCCHHHHHHHHHHHTT------SCHHHHHHHHHHTTTCCCSSHHH-----HHHHHHHHGGGGGBS-CHHHHHHHH T ss_pred CcchhccCHHHHHHHHHHhhc------CCHHHHHHHHHHHHHhCCCCHHH-----HHHHHHHHHHHhcCC-CHHHHHHHH Confidence 1 1111112355555555554 25677778888888877542211 112455556666655 677788888 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .++..+.. T Consensus 248 ~~l~~l~~ 255 (570) T 6CRI_I 248 KVLMKFME 255 (570) T ss_dssp HHHHHHTT T ss_pred HHHHHHHH Confidence 87777764 No 386 >4QMI_B Cytoskeleton-associated protein 5; PROTEIN BINDING, TOG domain; 1.9A {Homo sapiens} Probab=82.55 E-value=0.084 Score=45.96 Aligned_cols=112 Identities=11% Similarity=0.091 Sum_probs=68.9 Template_Neff=12.600 Q NP_000290.2 595 KGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP 673 (747) Q Consensus 595 giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~ 673 (747) .+++.+...+.+.++.++..++.++..+...... ...+ ..+++.+...+.+ .++.++..++.++..++...+ T Consensus 19 ~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~~~~~~~~~~-~~~~~~l~~~l~d------~~~~vr~~a~~~l~~l~~~~~ 91 (240) T 4QMI_B 19 KITSELVSKIGDKNWKIRKEGLDEVAGIINDAKFIQPNI-GELPTALKGRLND------SNKILVQQTLNILQQLAVAMG 91 (240) T ss_dssp GSCHHHHHHHTCSSHHHHHHHHHHHHHHHHHHCSBCSCC-TTHHHHHHHHTTC------SSHHHHHHHHHHHHHHHHHHG T ss_pred hccHHHHHHhcCCCHHHHHHHHHHHHHHHcCchHhccch-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhc Confidence 3455666667777788888888888888765211 1111 2345556666655 367888888888888876532 Q NP_000290.2 674 QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 674 e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ....... ...++.++..+.+. +..++..++.++..+.... T Consensus 92 ~~~~~~~-~~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~~~~ 131 (240) T 4QMI_B 92 PNIKQHV-KNLGIPIITVLGDS-KNNVRAAALATVNAWAEQT 131 (240) T ss_dssp GGGGGGC-CCCCHHHHHHTTCS-SHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHH-HHHHHHHHHHhhcC-CHHHHHHHHHHHHHHHHHh Confidence 2111111 23456666666655 5667777777777776553 No 387 >4QMJ_A Cytoskeleton-associated protein 5; PROTEIN BINDING, TOG DOMAIN; 2.498A {Homo sapiens} Probab=82.55 E-value=0.084 Score=45.96 Aligned_cols=112 Identities=11% Similarity=0.091 Sum_probs=68.9 Template_Neff=12.600 Q NP_000290.2 595 KGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP 673 (747) Q Consensus 595 giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~ 673 (747) .+++.+...+.+.++.++..++.++..+...... ...+ ..+++.+...+.+ .++.++..++.++..++...+ T Consensus 19 ~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~~~~~~~~~~-~~~~~~l~~~l~d------~~~~vr~~a~~~l~~l~~~~~ 91 (240) T 4QMJ_A 19 KITSELVSKIGDKNWKIRKEGLDEVAGIINDAKFIQPNI-GELPTALKGRLND------SNKILVQQTLNILQQLAVAMG 91 (240) T ss_dssp TSCHHHHHHHTCSSHHHHHHHHHHHHHHHHHHSSBCSCC-TTHHHHHHHHTTC------SSHHHHHHHHHHHHHHHHHHG T ss_pred hccHHHHHHhcCCCHHHHHHHHHHHHHHHcCchHhccch-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhc Confidence 3455666667777788888888888888765211 1111 2345556666655 367888888888888876532 Q NP_000290.2 674 QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 674 e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) ....... ...++.++..+.+. +..++..++.++..+.... T Consensus 92 ~~~~~~~-~~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~~~~ 131 (240) T 4QMJ_A 92 PNIKQHV-KNLGIPIITVLGDS-KNNVRAAALATVNAWAEQT 131 (240) T ss_dssp GGGGGGC-CCCCHHHHHGGGCS-SHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHH-HHHHHHHHHHhhcC-CHHHHHHHHHHHHHHHHHh Confidence 2111111 23456666666655 5667777777777776553 No 388 >6MZG_E Tubulin alpha-1A chain, Tubulin beta; Microtubule, Tubulin, Tubulin polymerization, Heat; HET: GTP, GDP; 3.208A {Sus scrofa} Probab=82.53 E-value=0.084 Score=52.43 Aligned_cols=147 Identities=12% Similarity=0.077 Sum_probs=92.8 Template_Neff=12.700 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQ--LIGLKEKGLPQIARLL-QSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~--~llie~giI~~Ll~LL-~s~d~eVr~~AL~aLsnLa~~ 625 (747) ++.+...+. +.++.++..++..|..++..... . .. .. .-..+++.+...+ .+.++.++..++.++..++.. T Consensus 315 ~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~---~-~~~~~~-~~~~i~~~l~~~l~~d~~~~v~~~a~~~l~~l~~~ 388 (554) T 6MZG_E 315 PADFQTRIS-STKWKDRVEALEEIHNNVLKPVK---K-LAHKNQ-DYSDYLRVLANVIQKDANVQAVTIAANSVQLLCNS 388 (554) T ss_dssp CSTTTTTTT-CSCHHHHHHHHHHCCCCCCTTCS---C-BCCSSC-CTHHHHHHHHHHHHHCSCHHHHHHHHHHHHHHHHH T ss_pred CHHHHHHhc-CCCHHHHHHHHHHHHHhhhcchh---H-HhccCC-cHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHH Confidence 344666666 46677888899999888764221 0 00 01 1135677777777 777888999999999988865 Q NP_000290.2 626 P-LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 626 ~-e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) . .. .......+++.+...+.+ .+..++..++.+|..++.... ...+++.+...+.+. ++.++.. T Consensus 389 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~l~~~~~-------~~~~~~~l~~~l~~~-~~~vr~~ 454 (554) T 6MZG_E 389 LRSNFTRSYGAIVLVPLLERTKE------KKPSVNEAICSALDAVATYCG-------FDDCLEETLNYMKHK-TPQVRIE 454 (554) T ss_dssp STTCCSSHHHHHHHHHHHHGGGC------CCHHHHHHHHHHHHHHHTTSS-------SSSHHHHHHHHHTCS-CHHHHHH T ss_pred hhccccHHHHHhhHHHHHHHhhh------ccHHHHHHHHHHHHHHHHHcC-------HHHHHHHHHHHhcCC-CHHHHHH Confidence 1 11 101112356666666655 256788888888888876421 123455666666554 6778888 Q NP_000290.2 704 ARLLLSDMWSSK 715 (747) Q Consensus 704 AL~aLsnL~~~~ 715 (747) ++.+|..++... T Consensus 455 ~~~~l~~l~~~~ 466 (554) T 6MZG_E 455 CTKFLTRMLQGW 466 (554) T ss_dssp HHHHHHHHHHTC T ss_pred HHHHHHHHHccC Confidence 888888776543 No 389 >1B3U_A PROTEIN PHOSPHATASE PP2A, 65 KD; SCAFFOLD PROTEIN, PP2A, PHOSPHORYLATION, HEAT; 2.3A {Homo sapiens} SCOP: a.118.1.2 Probab=82.32 E-value=0.085 Score=51.84 Aligned_cols=147 Identities=13% Similarity=0.119 Sum_probs=94.4 Template_Neff=13.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.+...+. +.++.++..++.+|..+...... .. ....+++.+...+.+.++.++..++.++..+.... T Consensus 164 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-------~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~ 234 (588) T 1B3U_A 164 ELRQYFRNLCS-DDTPMVRRAAASKLGEFAKVLEL-------DN-VKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLL 234 (588) T ss_dssp HHHHHHHHHHT-CSCHHHHHHHHHHHHHHHHTSCH-------HH-CCCCCHHHHHHHHTCSCHHHHTTHHHHHHHHHHHS T ss_pred HHHHHHHHHcc-CCCHHHHHHHHHHHHHHHHHcCh-------hh-hhhhhHHHHHHHhcCCCHHHHHHHHHHHHHHHHhC Confidence 35566667776 46778888898888888763221 11 12456677777777778888999999888887641 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) ... .....+++.+..++.+ .++.++..++.++..+....+. .......++.+...+.+. ++.++..++. T Consensus 235 ~~~-~~~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~~~~~~~~---~~~~~~~~~~l~~~l~~~-~~~~r~~a~~ 303 (588) T 1B3U_A 235 PQE-DLEALVMPTLRQAAED------KSWRVRYMVADKFTELQKAVGP---EITKTDLVPAFQNLMKDC-EAEVRAAASH 303 (588) T ss_dssp CHH-HHHHHTHHHHHHHHTC------SSHHHHHHHHHTHHHHHHHHCH---HHCCCCCHHHHHHHHTCS-SHHHHHHHHH T ss_pred CHH-HHHHHHHHHHHHHHhC------CCHHHHHHHHhhHHHHHHHHCC---CCCHHhHHHHHHHHhccC-HHHHHHHHHH Confidence 111 1112345556666655 3677888888888888754221 111224566666666655 6778888888 Q NP_000290.2 707 LLSDMWS 713 (747) Q Consensus 707 aLsnL~~ 713 (747) ++..+.. T Consensus 304 ~l~~l~~ 310 (588) T 1B3U_A 304 KVKEFCE 310 (588) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 8877765 No 390 >2OF3_A ZYG-9; Multifunctional macromolecule, Kinetochore, microtubule, XMAP215; 1.9A {Caenorhabditis elegans} Probab=81.96 E-value=0.098 Score=48.11 Aligned_cols=150 Identities=9% Similarity=-0.036 Sum_probs=91.9 Template_Neff=11.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... .........-..+++.++..+.+.+..++..+..+|..+..... T Consensus 88 l~~~l~~~l~-d~~~~v~~~a~~~l~~l~~~~~~--~~~~~~~~~~~~ll~~l~~~l~d~~~~vr~~a~~~l~~l~~~~~ 164 (266) T 2OF3_A 88 LLKWCTLRFF-ETNPAALIKVLELCKVIVELIRD--TETPMSQEEVSAFVPYLLLKTGEAKDNMRTSVRDIVNVLSDVVG 164 (266) T ss_dssp HHHHHHHHTT-SCCHHHHHHHHHHHHHHHHHHHH--TTCCCCHHHHHHHHHHHHHGGGCSSHHHHHHHHHHHHHHHHHHC T ss_pred HHHHHHHHHh-CCCHHHHHHHHHHHHHHHHHHHh--CCCCCCHHHHHhHHHHHHHHhCCCcHHHHHHHHHHHHHHHHhhC Confidence 3455555666 46677888888888888764221 00000000013456677777777777788888888887765421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) . ..+++.+...+.+ .++.++..++.+|..+........... ..+++.+...+.+. ++.++..++.+ T Consensus 165 ~-----~~~~~~l~~~l~~------~~~~~r~~~l~~l~~~~~~~~~~~~~~--~~ii~~l~~~l~d~-~~~VR~~a~~~ 230 (266) T 2OF3_A 165 P-----LKMTPMLLDALKS------KNARQRSECLLVIEYYITNAGISPLKS--LSVEKTVAPFVGDK-DVNVRNAAINV 230 (266) T ss_dssp H-----HHHHHHHHHGGGC------SCHHHHHHHHHHHHHHHHHHCSGGGGG--GCHHHHHGGGGGCS-SHHHHHHHHHH T ss_pred H-----HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhCCccccc--ChHHHHHHHHHcCC-CHHHHHHHHHH Confidence 1 1234445555544 357778888888888775432211111 34667777777766 78899999999 Q NP_000290.2 708 LSDMWSS 714 (747) Q Consensus 708 LsnL~~~ 714 (747) +..+... T Consensus 231 l~~l~~~ 237 (266) T 2OF3_A 231 LVACFKF 237 (266) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 8888754 No 391 >4I5L_D PP2A A alpha subunit (9-589); EF Hand, Phosphatase, CDC6 (Substrate); HET: FGA, ACB, DAL, MLI, PEG, 1ZN, MAA; 2.43A {Microcystis aeruginosa} Probab=81.77 E-value=0.092 Score=51.50 Aligned_cols=147 Identities=13% Similarity=0.130 Sum_probs=94.5 Template_Neff=13.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.+...+. +.++.++..++.+|..+...... . . ....+++.+...+.+.++.++..++.++..+.... T Consensus 160 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~------~-~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~ 230 (584) T 4I5L_D 160 ELRQYFRNLCS-DDTPMVRRAAASKLGEFAKVLEL------D-N-VKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLL 230 (584) T ss_dssp HHHHHHHHHHT-CSSHHHHHHHHHHHHHHHTTSCH------H-H-CCCCCHHHHHHHTTCSCHHHHTTHHHHHHHHHHHS T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHcCh------h-h-hhcchHHHHHHHhCCCCHHHHHHHHHHHHHHHHhC Confidence 34566667776 46778888899888888764221 1 1 12456677777787778888999999988887641 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) ... .....+++.+..++.+ .++.++..++.++..+....+. .......++.+...+.+. ++.++..++. T Consensus 231 ~~~-~~~~~~~~~l~~~l~~------~~~~vr~~~~~~l~~l~~~~~~---~~~~~~~~~~l~~~l~~~-~~~vr~~a~~ 299 (584) T 4I5L_D 231 PQE-DLEALVMPTLRQAAED------KSWRVRYMVADKFTELQKAVGP---EITKTDLVPAFQNLMKDC-EAEVRAAASH 299 (584) T ss_dssp CTT-THHHHTHHHHHHHHTC------SSHHHHHHHHHTHHHHHHHHHH---HHCCCCCHHHHHHHHTCS-SHHHHHHHHT T ss_pred CHH-HHHHHHHHHHHHHhhC------CCHHHHHHHHHHHHHHHHHHCC---CCChhhHHHHHHHHhcCC-cHHHHHHHHH Confidence 111 1112345556666655 3677888888888888754221 111224566666666655 6778888888 Q NP_000290.2 707 LLSDMWS 713 (747) Q Consensus 707 aLsnL~~ 713 (747) ++..+.. T Consensus 300 ~l~~l~~ 306 (584) T 4I5L_D 300 KVKEFCE 306 (584) T ss_dssp THHHHHH T ss_pred HHHHHHH Confidence 8887765 No 392 >4Y5J_A Mini spindles TOG3; XMAP215, TOG, microtubule polymerization; 2.303A {Drosophila melanogaster} Probab=81.72 E-value=0.097 Score=46.19 Aligned_cols=71 Identities=13% Similarity=0.043 Sum_probs=45.8 Template_Neff=12.300 Q NP_000290.2 548 AIRT-YLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIA---RLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~-LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll---~LL~s~d~eVr~~AL~aLsnLa 623 (747) .++. ++..+. +.++.++..++..|..++..... .... ....+++.+. ..+.+.++.++..++.++..++ T Consensus 15 ~l~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~~~~-----~~~~-~~~~l~~~l~~l~~~l~d~~~~v~~~a~~~l~~l~ 87 (248) T 4Y5J_A 15 ILPAEILNGLV-DSNWKNRLAAVEQLLGEISGFDA-----KQAG-ISQILIRTISGRKPGLKEMNFQVLKFKLDIIRSVA 87 (248) T ss_dssp CCCHHHHHHHH-CSSHHHHHHHHHHHHHHGGGSCT-----TSTT-HHHHHHHHHHSSSSGGGCSSHHHHHHHHHHHHHHH T ss_pred hcCHHHHHhhc-CcCHHHHHHHHHHHHHHHccCch-----hccc-hHHHHHHHHhcCCCchhhccHHHHHHHHHHHHHHH Confidence 4555 777776 46778888899999888764221 0111 1123444444 5666667788888888888887 Q NP_000290.2 624 RH 625 (747) Q Consensus 624 ~~ 625 (747) .. T Consensus 88 ~~ 89 (248) T 4Y5J_A 88 EN 89 (248) T ss_dssp HH T ss_pred Hh Confidence 54 No 393 >4P6Z_G BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=81.57 E-value=0.1 Score=53.70 Aligned_cols=137 Identities=17% Similarity=0.119 Sum_probs=87.9 Template_Neff=12.000 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL 628 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~ 628 (747) +..++.++. +.+..++..++.+|..+....+. . ...+++.+...+.+.++.++..++.+|..+..... T Consensus 81 ~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~- 148 (627) T 4P6Z_G 81 QLECLKLIA-SQKFTDKRIGYLGAMLLLDERQD--------V--HLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEM- 148 (627) T ss_dssp HHHHHHHHT-SSSHHHHHHHHHHHHHHCCTTSC--------C--HHHHHHHHHHHHTCSSHHHHHHHHHHHHHHCCHHH- T ss_pred HHHHHHHHc-CCCCchhHHHHHHHHHHCCCChH--------H--HHHHHHHHHHHhhCCCHHHHHHHHHHHHhcCCHHH- Confidence 344556666 46677777888888777653221 1 12345566666777778888888888887764211 Q NP_000290.2 629 HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLL 708 (747) Q Consensus 629 ~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aL 708 (747) ...+++.+..++.+ .++.++..++.+|..+....+... ..+++.|...+.+. ++.++..++.++ T Consensus 149 ----~~~~~~~l~~~l~~------~~~~vr~~a~~~L~~l~~~~~~~~-----~~~~~~l~~~l~~~-~~~vr~~a~~~l 212 (627) T 4P6Z_G 149 ----CRDLAGEVEKLLKT------SNSYLRKKAALCAVHVIRKVPELM-----EMFLPATKNLLNEK-NHGVLHTSVVLL 212 (627) T ss_dssp ----HHHHHHHHHHHHTC------SCHHHHHHHHHHHHHHHHHCSGGG-----GGGHHHHTTCTTCC-CHHHHHHHHHHH T ss_pred ----HHHHHHHHHHHhhC------CCHHHHHHHHHHHHHHHHHCHHHH-----HHHHHHHHHHHhCC-CHHHHHHHHHHH Confidence 12345666666665 367888889999988876433221 24566677777655 677888888888 Q NP_000290.2 709 SDMWS 713 (747) Q Consensus 709 snL~~ 713 (747) ..+.. T Consensus 213 ~~~~~ 217 (627) T 4P6Z_G 213 TEMCE 217 (627) T ss_dssp HHHHH T ss_pred HHHHH Confidence 77754 No 394 >5KC2_B Phosphatidylinositol 3-kinase VPS34 (E.C.2.7.1.137), Serine/threonine-protein; autophagy, phosphatidylinositol 3-kinase (PtdIns3K), endocytosis; 28.0A {Saccharomyces cerevisiae} Probab=81.46 E-value=0.11 Score=61.49 Aligned_cols=126 Identities=13% Similarity=0.064 Sum_probs=72.5 Template_Neff=9.500 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETR 326 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll 326 (747) ++.|..++.+.++.++..++.+|..+.... ....+.. ..++.|+.++.+.++.++..++.+|..+..........+. T Consensus 621 l~~L~~~l~d~~~~vR~~a~~al~~l~~~~--~~~~~~~-~~lp~L~~lL~d~~~~vr~~al~aL~~L~~~~~~~~~~~~ 697 (1454) T 5KC2_B 621 LSHLITYLNDKDPALRVSLIQTISGISILL--GTVTLEQ-YILPLLIQTITDSEELVVISVLQSLKSLFKTGLIRKKYYI 697 (1454) T ss_pred HHHHHHHccCCCHHHHHHHHHHHHHHHHhh--HHHHHHH-cCHHHHHHHhcCCCHHHHHHHHHHHHHHhhCCHHHHHHHH Confidence 444555555566667777777776666432 1112222 2266777777776777788888888877653322222221 Q NP_000290.2 327 RQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRV 379 (747) Q Consensus 327 ~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~~~~~~~LvegiLe~Lv~LL 379 (747) ..++.+..++. +.++.++..+..+|..|+...... .....+++.|+.+| T Consensus 698 --~~l~~l~~~l~-~~~~~vr~~a~~~L~~l~~~~~~~-~~~~~~~~~L~~~L 746 (1454) T 5KC2_B 698 --DISKTTSPLLL-HPNNWIRQFTLMIIIEIINKLSKA-EVYCILYPIIRPFF 746 (1454) T ss_pred --HHHHHHHHHHC-CCCHHHHHHHHHHHHHHhcCCCCH-HHHcChHHHHHHHh Confidence 25556666665 457778888888888877643221 11134555555555 No 395 >6MZG_E Tubulin alpha-1A chain, Tubulin beta; Microtubule, Tubulin, Tubulin polymerization, Heat; HET: GTP, GDP; 3.208A {Sus scrofa} Probab=81.15 E-value=0.1 Score=51.71 Aligned_cols=151 Identities=11% Similarity=0.102 Sum_probs=93.6 Template_Neff=12.700 Q NP_000290.2 550 RTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIAR-LLQSGNSDVVRSGASLLSNMSRHPLL 628 (747) Q Consensus 550 ~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~-LL~s~d~eVr~~AL~aLsnLa~~~e~ 628 (747) +.+...+. +.++.++..++.+|..++..... ........ ....+++.++. ++.+.++.++..++.+|..++..... T Consensus 57 ~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~-~~~~~~~~-~~~~~l~~l~~~~~~~~~~~vr~~a~~~L~~l~~~~~~ 133 (554) T 6MZG_E 57 ELFASYIV-DSNVVAQENAIIALHTLLEYISQ-VPNVSTSK-LRLQWIPPLVEKGLSSSRAATKAKATDCIMLLTQSDTS 133 (554) T ss_dssp HHHHHHTT-CSSHHHHHHHHHHHHHHHHHTCS-SSCCTHHH-HHHHHHHHHCCCCCSCSCHHHHHHHHHHHHHHHHTSSS T ss_pred HHHHHhcC-CccHHHHHHHHHHHHHHHHHHhc-CCCCCcHH-HHHhcHHHHHHHhccCCcHHHHHHHHHHHHHHHhcccc Confidence 55666776 47788899999999988764221 00000001 11345666666 45666788889999999888754111 Q NP_000290.2 629 HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK---QYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 629 ~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~---~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+...+.+ .++.++..++.+|..++........ ......+++.+...+.+. ++.++..++ T Consensus 134 ----~~~~~~~l~~~l~~------~~~~vr~~~~~~l~~l~~~~~~~~~~~~~~~~~~i~~~l~~~l~~~-~~~vr~~a~ 202 (554) T 6MZG_E 134 ----IQQTVNLMLPSLSN------KLPRLVSSCVKCLATIIEEFGFINVSDINILLSEILEPLPKLSSHA-DRNVRSETM 202 (554) T ss_dssp ----SHHHHHHHSGGGGC------SCHHHHHHHHHHHHHHHHHTCSCSCSCHHHHHHHHHSSHHHHTTCS-SHHHHHHHH T ss_pred ----HHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhCCCccccccccHHHHHHHHHHHhhcC-CHHHHHHHH Confidence 11244555555554 3677888899999888764221110 001234567777777766 788999999 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..+... T Consensus 203 ~~l~~l~~~ 211 (554) T 6MZG_E 203 NLILQIYKW 211 (554) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHH Confidence 998888754 No 396 >6MZE_Z Tubulin alpha-1A chain, Tubulin beta; Microtubule, Tubulin, Tubulin polymerization, Heat; HET: MG, GTP, GDP; 3.6A {Sus scrofa} Probab=81.14 E-value=0.1 Score=51.20 Aligned_cols=108 Identities=11% Similarity=0.069 Sum_probs=63.0 Template_Neff=12.900 Q NP_000290.2 600 IARLLQSGNSDVVRSGASLLSNMSRHPL-LHR---VMGNQVFPEVTRLL-TSHTGNTSNSEDILSSACYTVRNLMASQPQ 674 (747) Q Consensus 600 Ll~LL~s~d~eVr~~AL~aLsnLa~~~e-~~~---ll~~giI~~Ll~LL-~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e 674 (747) +...+.+.+..++..++.+|..++.... ... .....+++.+...+ .+ .++.++..++.++..++..... T Consensus 300 l~~~l~~~~~~~r~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~d------~~~~v~~~a~~~l~~l~~~~~~ 373 (536) T 6MZE_Z 300 FQTRISSTKWKDRVEALEEIHNNVLKPVKKLAHKNQDYSDYLRVLANVIQKD------ANVQAVTIAANSVQLLCNSLRS 373 (536) T ss_dssp GHHHHSCSSHHHHHHHHHHCCCCCCSSCSCBCCTTCCCTTTHHHHHHHHHHC------SCHHHHHHHHHHHHHHHHHTTT T ss_pred HHHHhhcCCHHHHHHHHHHHHHHhhccchhhccCCCCHHHHHHHHHHHHhcC------chHHHHHHHHHHHHHHHHHccc Confidence 4455555667778888888888775411 100 11123556666666 54 3678888899999888764322 Q NP_000290.2 675 LAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 675 ~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) .........+++.++..+.+. +..++..++.+|..++.. T Consensus 374 ~~~~~~~~~~~~~l~~~l~~~-~~~vr~~a~~~l~~l~~~ 412 (536) T 6MZE_Z 374 NFTRSYGAIVLVPLLERTKEK-KPSVNEAICSALDAVATY 412 (536) T ss_dssp CCSSHHHHHHHHHHHHHTTCC-CHHHHHHHHHHHHHHHHT T ss_pred cccHHHHHHHHHHHHHHhhcc-CHHHHHHHHHHHHHHHHh Confidence 111011123455666666554 566777777777776654 No 397 >6RXU_UJ Periodic tryptophan protein 2-like protein; ribosome, ribosome biogenesis, rRNA; HET: GTP; 3.5A {Chaetomium thermophilum} Probab=80.93 E-value=0.12 Score=62.49 Aligned_cols=152 Identities=9% Similarity=0.051 Sum_probs=85.8 Template_Neff=9.700 Q NP_000290.2 548 AIRTYLNLMGKS-----KKDATLEACAGALQNLTASKGLMSSGMSQ--LIGLKEKGLPQIARLLQSG--------NSDVV 612 (747) Q Consensus 548 ~I~~LL~LL~ss-----~d~eVr~~AL~aL~nLs~~s~~~s~~~~~--~llie~giI~~Ll~LL~s~--------d~eVr 612 (747) +++.++..+... .+..++..++.+|..++..... .... .. -..+++.|...+... ...++ T Consensus 1625 il~~ll~~L~~~~~~~~~~~~v~~~~l~~L~~l~~~~~~---~~~~~~~~--~~~ll~~L~~~L~~~~~~~~~~~~~~v~ 1699 (1802) T 6RXU_UJ 1625 IVDASVKALKAVDFAVPEERNLWKRVLCTLAKCFEHDQD---GFWQAPAH--FGAVAPVLVEQFLRAEGQVTATNVNDVI 1699 (1802) T ss_pred HHHHHHHHHhcCCCCCCCCHHHHHHHHHHHHHHHHHhCh---hhhcChhH--HHHHHHHHHHHHhCCCCCCCccccHHHH Confidence 345555555521 2456777788888877764221 0000 11 134556666666532 23567 Q NP_000290.2 613 RSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLC 692 (747) Q Consensus 613 ~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL 692 (747) ..++.+++.++.......+. ..+++.++..+.+ .++.++..++.++..++.........+. ..+++.+...+ T Consensus 1700 ~~ai~~L~~l~~~~~~~~~~-~~l~~~ll~~l~~------~~~~vR~~al~~L~~l~~~~g~~~~~~l-~~ii~~L~elL 1771 (1802) T 6RXU_UJ 1700 QDVVPAVVELAAAVESQEHY-KEINTALLKHLRN------GSPGVRLAVVKCQQAITAKLGEDWLHLL-PEMLPYISELQ 1771 (1802) T ss_pred HHHHHHHHHHHHHhCCchHH-HhHHHHHHHHcCC------CCHHHHHHHHHHHHHHHHHHcHhhHHhH-HHHHHHHHHHh Confidence 77888888877531111111 1234445555544 3567888999999988765332222222 24567777777 Q NP_000290.2 693 RSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 693 ~s~~d~eVr~aAL~aLsnL~~ 713 (747) ++. ++.++..+..++..+.. T Consensus 1772 eD~-d~~V~~~a~~~l~~l~~ 1791 (1802) T 6RXU_UJ 1772 DDD-DEVVERENRRWIVGIEE 1791 (1802) T ss_pred cCC-CHHHHHHHHHHHHHHHH Confidence 766 77788888777776654 No 398 >5FVM_B SERINE/THREONINE-PROTEIN KINASE TOR2, TARGET OF; TRANSFERASE, CRYO-EM, TOR, LST8, MTOR; 6.7A {KLUYVEROMYCES MARXIANUS} Probab=80.75 E-value=0.12 Score=63.47 Aligned_cols=147 Identities=12% Similarity=0.092 Sum_probs=75.7 Template_Neff=11.500 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.+...+. + ..++..++.++..++..... ....+ -..+++.++..+.+.+..++..++.++..+..... T Consensus 1008 i~~~l~~~l~-~--~~vr~~a~~~l~~l~~~~~~-----~~~~~-~~~ll~~l~~~l~~~~~~~r~~a~~~l~~l~~~~~ 1078 (2471) T 5FVM_B 1008 IVDVISEFFP-V--LKLQLTIISVIESLSRALEG-----EFNPH-LPTILSLFLDVLEKDQSNKKVVSVRILKSLVVFGP 1078 (2471) T ss_dssp HHHTTC------------CTHHHHHHHHHTTSSC-----CHHHH-HHHHHHHHHHHHC----CCHHHHHHHHHHHHHHCS T ss_pred HHHHHHHHcc-c--hhHHHHHHHHHHHHHHHccc-----ChHHH-HHHHHHHHHHHHccCCCCcHHHHHHHHHHHHHHhh Confidence 3444555444 1 45666778888877754221 01111 23566777777776666677777777776654321 Q NP_000290.2 628 L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 628 ~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) . ...+ ..+++.+...+.+ .++.++..++.+|..++..... .. ....++..++..+.+. ++.++..++. T Consensus 1079 ~~~~~l-~~il~~l~~~l~~------~~~~vr~~al~~l~~l~~~~~~--~~-~~~~i~~~l~~~l~~~-~~~vr~~a~~ 1147 (2471) T 5FVM_B 1079 HLEEYV-HLVLPTIIKLSEF------SSGNLKKAAIITIGRLSKNVNA--LE-MSSRIVQALVRVLNTS-ETEYVKATMN 1147 (2471) T ss_dssp SCCCHH-HHHHHHHHTTC---------CCHHHHHHHHHHHHHHHC-CC--HH-HHHHHHHHHHHHCC---CTHHHHHHHH T ss_pred hHHHHH-HHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhhCCh--HH-HHHHHHHHHHHHHcCC-ChHHHHHHHH Confidence 1 1111 2355666666655 2567888888888888754221 11 1124566666777655 6677888888 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) +|..++.. T Consensus 1148 ~l~~l~~~ 1155 (2471) T 5FVM_B 1148 TLSLLLLQ 1155 (2471) T ss_dssp HHHHHHHC T ss_pred HHHHHHHH Confidence 88777643 No 399 >6GWC_C Tubulin alpha chain, Tubulin beta; microtubule, ARTIFICIAL PROTEIN, ALPHAREP, cytoskeleton; HET: GTP, MES, PGE; 2.6A {Ovis aries} Probab=80.69 E-value=0.11 Score=45.32 Aligned_cols=49 Identities=8% Similarity=0.093 Sum_probs=29.6 Template_Neff=12.200 Q NP_000290.2 654 SEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 654 d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++.++..++.+|..+... ..++.+..++.+. ++.++..++.++..+... T Consensus 120 ~~~~r~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~~~ 168 (232) T 6GWC_C 120 DTTVRRIAATALGKIGDE-----------RAVEPLIKALKDE-DAAVRLTAARALGEIGDE 168 (232) T ss_pred CHHHHHHHHHHHHHhccc-----------chHHHHHHHhcCC-CHHHHHHHHHHHHHhCCh Confidence 455556666666555321 2344455566655 677888888888877653 No 400 >1OYZ_A X-RAY STRUCTURE OF YB61_HAEIN NORTHEAST; STRUCTURAL GENOMICS, PSI, Protein Structure; 2.1A {Escherichia coli} SCOP: a.118.1.16 Probab=80.56 E-value=0.11 Score=46.13 Aligned_cols=64 Identities=13% Similarity=0.063 Sum_probs=32.1 Template_Neff=12.700 Q NP_000290.2 549 IRTYLN-LMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 549 I~~LL~-LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) ++.+.. ++. +.++.++..++.+|..+....+. .....++.+...+.+.++.++..++.+|..+. T Consensus 92 ~~~l~~~~l~-~~~~~vr~~a~~~l~~~~~~~~~----------~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~~~ 156 (280) T 1OYZ_A 92 FNILNNMALN-DKSACVRATAIESTAQRCKKNPI----------YSPKIVEQSQITAFDKSTNVRRATAFAISVIN 156 (280) T ss_dssp HHHHHHHHHH-CSCHHHHHHHHHHHHHHHHHCGG----------GHHHHHHHHHHHTTCSCHHHHHHHHHHHHTC- T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhcCcc----------cChhHHHHHHHHhcCCCHHHHHHHHHHHHhhc Confidence 344444 444 34556666666666665532110 11233445555555555666666666665544 No 401 >6GX7_F Tubulin alpha chain, Tubulin beta; microtubule, ALPHAREP, CELL CYCLE, COPN; HET: MES, PGE, SO4, GOL, GTP; 3.19A {Ovis aries} Probab=80.46 E-value=0.12 Score=44.09 Aligned_cols=122 Identities=14% Similarity=0.214 Sum_probs=55.9 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++..+..+.. ...++.+..++.+.++.++..++.++..+... T Consensus 46 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~----------------~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~-- 106 (201) T 6GX7_F 46 AVEPLIKALK-DEDPWVRREAAGALGQIGD----------------ERAVEPLIKALKDEDRYVRRIAARALGKIGDE-- 106 (201) T ss_dssp GHHHHHHHTT-CSSHHHHHHHHHHHHHHTC----------------GGGHHHHHHHTTCSSHHHHHHHHHHHHHHTCG-- T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHCC----------------HHHHHHHHHHhcCCCHHHHHHHHHHHhhcCCh-- Confidence 3444555554 2445555555555544321 11233344445555555666666666555421 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ..++.+...+.+ .++.++..++.++..+... ..++.+..++.+. +..++..++.+ T Consensus 107 -------~~~~~l~~~l~~------~~~~v~~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~vr~~a~~~ 161 (201) T 6GX7_F 107 -------RAVEPLIKALKD------EDWQVREDAAKALGQIGDE-----------RAVEPLIKALKDE-DTTVRLEAALA 161 (201) T ss_dssp -------GGHHHHHHHTTC------SSHHHHHHHHHHHHHHTCG-----------GGHHHHHHHTTCS-SHHHHHHHHHH T ss_pred -------hhHHHHHHHhhc------CCHHHHHHHHHHHHHhCCH-----------HHHHHHHHHHhCC-CHHHHHHHHHH Confidence 122333333433 2345555555555554321 1233333444433 45555566666 Q NP_000290.2 708 LSDMWS 713 (747) Q Consensus 708 LsnL~~ 713 (747) +..+.. T Consensus 162 l~~~~~ 167 (201) T 6GX7_F 162 LGKIGG 167 (201) T ss_dssp HHHHCS T ss_pred HHhhcc Confidence 555543 No 402 >2NYL_A Protein phosphatase 2, regulatory subunit; HEAT repeat, HYDROLASE-HYDROLASE INHIBITOR COMPLEX; HET: DAL, MSE, ACB, 1ZN, DAM, FGA; 3.8A {Homo sapiens} SCOP: a.118.1.2 Probab=80.40 E-value=0.11 Score=50.67 Aligned_cols=147 Identities=13% Similarity=0.119 Sum_probs=93.6 Template_Neff=13.500 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.+..++. +.++.++..++.++..+...... .. ....+++.+...+.+.++.++..++.++..+.... T Consensus 158 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-------~~-~~~~~~~~l~~~~~~~~~~~r~~a~~~l~~l~~~~ 228 (582) T 2NYL_A 158 ELRQYFRNLCS-DDTPMVRRAAASKLGEFAKVLEL-------DN-VKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLL 228 (582) T ss_dssp HHHHHHHHHHS-CSCHHHHHHHHHHHHHHHTTSCH-------HH-CCCCCHHHHHHHTSCSCHHHHHHHHHHHHHHHHHS T ss_pred HHHHHHHHHcc-CCCHHHHHHHHHHHHHHHHHcCh-------hh-hHhhHHHHHHHHhhCCCHHHHHHHHHHHHHHHHHC Confidence 35566667776 46778888899988888763221 11 12456677777777777888888988888887641 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) ... .....+++.+...+.+ .++.++..++.++..+....+. .......++.+...+.+. ++.++..++. T Consensus 229 ~~~-~~~~~~~~~l~~~l~~------~~~~vr~~~~~~l~~~~~~~~~---~~~~~~~~~~l~~~l~~~-~~~v~~~a~~ 297 (582) T 2NYL_A 229 PQE-DLEALVMPTLRQAAED------KSWRVRYMVADKFTELQKAVGP---EITKTDLVPAFQNLMKDC-EAEVRAAASH 297 (582) T ss_dssp CHH-HHTTTTHHHHHHHHHC------SSHHHHHHHHHTHHHHHHHHCS---HHCCCCCHHHHHHHHTCS-SHHHHHHHHT T ss_pred CHH-HHHHHHHHHHHHHhcC------CCHHHHHHHHHhHHHHHHHHCC---CCCHhhhHHHHHHHhcCC-hHHHHHHHHH Confidence 111 1112345556666655 3677888888888888754221 111223566666666655 6778888888 Q NP_000290.2 707 LLSDMWS 713 (747) Q Consensus 707 aLsnL~~ 713 (747) ++..+.. T Consensus 298 ~l~~~~~ 304 (582) T 2NYL_A 298 KVKEFCE 304 (582) T ss_dssp THHHHHH T ss_pred HHHHHHH Confidence 8877765 No 403 >5VJC_B Protein mini spindles; TOG, HEAT Repeat, Tubulin, CELL; 2.0A {Drosophila melanogaster} Probab=80.32 E-value=0.12 Score=47.18 Aligned_cols=72 Identities=13% Similarity=0.027 Sum_probs=44.4 Template_Neff=11.500 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .+.+.+...+. +.++.++..++..|..++..... ...... ..++..+...+.+.++.++..++.++..++.. T Consensus 50 ~~~~~l~~~l~-~~~~~~r~~a~~~L~~~~~~~~~-----~~~~~~-~~l~~~l~~~l~d~~~~vr~~a~~~l~~l~~~ 121 (271) T 5VJC_B 50 NVNKALIANMF-HDDFRYHLKVIEQLSEDLAGNSK-----ALVCNL-DLILKWLTLRFYDTNPSVLIKGLEYLVQVFQV 121 (271) T ss_dssp TCCHHHHHHHT-CSCHHHHHHHHHHHHHHTTTCHH-----HHHHTH-HHHHHHHHHHTTSSCHHHHHHHHHHHHHHHHH T ss_pred cCCHHHHHhcc-CCCHHHHHHHHHHHHHHHhcCHH-----HHHHHH-HHHHHHHHHHHhCCCHHHHHHHHHHHHHHHHH Confidence 34566777776 46777888888888888764321 011111 23344455555566777888888888877654 No 404 >6RXV_UJ Periodic tryptophan protein 2-like protein; ribosome, ribosome biogenesis, rRNA; HET: GTP; 4.0A {Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)} Probab=80.28 E-value=0.13 Score=62.13 Aligned_cols=152 Identities=9% Similarity=0.051 Sum_probs=86.0 Template_Neff=9.700 Q NP_000290.2 548 AIRTYLNLMGKS-----KKDATLEACAGALQNLTASKGLMSSGMSQ--LIGLKEKGLPQIARLLQSG--------NSDVV 612 (747) Q Consensus 548 ~I~~LL~LL~ss-----~d~eVr~~AL~aL~nLs~~s~~~s~~~~~--~llie~giI~~Ll~LL~s~--------d~eVr 612 (747) +++.++..+... .+..++..++.+|..++..... .... .. -..+++.|...+... ...++ T Consensus 1625 il~~ll~~L~~~~~~~~~~~~v~~~al~~L~~l~~~~~~---~~~~~~~~--~~~il~~L~~~L~~~~~~~~~~~~~~v~ 1699 (1802) T 6RXV_UJ 1625 IVDASVKALKAVDFAVPEERNLWKRVLCTLAKCFEHDQD---GFWQAPAH--FGAVAPVLVEQFLRAEGQVTATNVNDVI 1699 (1802) T ss_pred HHHHHHHHHHhcCCCChHHHHHHHHHHHHHHHHHhcCCC---CcccChhH--HHhHHHHHHHHHHhhcCCCCCccHHHHH Confidence 345555555521 2456777788888877764221 0000 11 134556666666532 23567 Q NP_000290.2 613 RSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLC 692 (747) Q Consensus 613 ~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL 692 (747) ..++.+++.++.......+. ..+++.++..+.+ .++.++..++.++..++.........+. ..+++.+...+ T Consensus 1700 ~~ai~~L~~l~~~~~~~~~~-~~l~~~ll~~l~~------~~~~vR~~al~~L~~l~~~~g~~~~~~l-~eii~~L~elL 1771 (1802) T 6RXV_UJ 1700 QDVVPAVVELAAAVESQEHY-KEINTALLKHLRN------GSPGVRLAVVKCQQAITAKLGEDWLHLL-PEMLPYISELQ 1771 (1802) T ss_pred HHHHHHHHHHHHHcCCHHHH-HHHHHHHHHHccC------CCHHHHHHHHHHHHHHHHHHCHhHHhhh-hHHHHHHHHHh Confidence 77888888877531111111 1234445555544 3567888999999988765332222222 24567777777 Q NP_000290.2 693 RSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 693 ~s~~d~eVr~aAL~aLsnL~~ 713 (747) ++. ++.++..+..++..+.. T Consensus 1772 eD~-d~~V~~~a~~~l~~l~~ 1791 (1802) T 6RXV_UJ 1772 DDD-DEVVERENRRWIVGIEE 1791 (1802) T ss_pred cCC-CHHHHHHHHHHHHHHHH Confidence 766 77788888777776654 No 405 >4I5L_D PP2A A alpha subunit (9-589); EF Hand, Phosphatase, CDC6 (Substrate); HET: FGA, ACB, DAL, MLI, PEG, 1ZN, MAA; 2.43A {Microcystis aeruginosa} Probab=80.24 E-value=0.11 Score=50.76 Aligned_cols=109 Identities=15% Similarity=0.189 Sum_probs=68.2 Template_Neff=13.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) ..++.+...+. +.++.++..++.++..+...... .. ....+++.+...+.+.++.++..++.++..+... T Consensus 238 ~~~~~l~~~l~-~~~~~vr~~~~~~l~~l~~~~~~-------~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~ 308 (584) T 4I5L_D 238 LVMPTLRQAAE-DKSWRVRYMVADKFTELQKAVGP-------EI-TKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENL 308 (584) T ss_dssp HTHHHHHHHHT-CSSHHHHHHHHHTHHHHHHHHHH-------HH-CCCCCHHHHHHHHTCSSHHHHHHHHTTHHHHHHTS T ss_pred HHHHHHHHHhh-CCCHHHHHHHHHHHHHHHHHHCC-------CC-ChhhHHHHHHHHhcCCcHHHHHHHHHHHHHHHHhc Confidence 35566666776 46778888888888887754221 11 1245667777778777788899999999888764 Q NP_000290.2 626 PLL-H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 626 ~e~-~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) ... . ......+++.+...+.+ .+..++..++.++..+.. T Consensus 309 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~~~~~l~~l~~ 349 (584) T 4I5L_D 309 SADCRENVIMSQILPCIKELVSD------ANQHVKSALASVIMGLSP 349 (584) T ss_dssp CTTTHHHHCCCCCHHHHHHHHTC------SCHHHHHHHHTTGGGGHH T ss_pred CccchhhHHHHhHHHHHHHHccC------CCHHHHHHHHHHHHHHHH Confidence 111 1 11123355555555554 245666777777766654 No 406 >1IBR_B RAN IMPORTIN BETA SUBUNIT; SMALL GTPASE NUCLEAR TRANSPORT; HET: GNP; 2.3A {Homo sapiens} SCOP: a.118.1.1 Probab=80.23 E-value=0.12 Score=49.62 Aligned_cols=156 Identities=10% Similarity=0.042 Sum_probs=86.8 Template_Neff=12.900 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLM------------SSGMSQ----LIGLKEKGLPQIARLLQSG----- 607 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~------------s~~~~~----~llie~giI~~Ll~LL~s~----- 607 (747) ++.+...+. +.++.++..++.++..++...... ...... .. .-..+++.+...+.+. T Consensus 261 ~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~l~~~l~~~l~~~~~~~~ 338 (462) T 1IBR_B 261 FAITIEAMK-SDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKG-ALQYLVPILTQTLTKQDENDD 338 (462) T ss_dssp HHHHHHHHH-CSSHHHHHHHHHHHHHHHHHHHHHHHHHCCTTCSSSCSSCCCCCHHHH-HHHHHHHHHHHHTTCCCSSCC T ss_pred HHHHHHHHh-cCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCcchhhHHhHHH-HHHHHHHHHHHhcccCCCCCC Confidence 555666666 356777778888888776531000 000000 00 0123344444444433 Q NP_000290.2 608 --NSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSM 684 (747) Q Consensus 608 --d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~gi 684 (747) +..++..+..++..++..... .....+++.+...+.+ .++.++..++.++..++...+. ...... ..+ T Consensus 339 ~~~~~~r~~a~~~l~~l~~~~~~--~~~~~~~~~l~~~l~~------~~~~~r~~al~~l~~l~~~~~~~~~~~~~-~~~ 409 (462) T 1IBR_B 339 DDDWNPCKAAGVCLMLLATCCED--DIVPHVLPFIKEHIKN------PDWRYRDAAVMAFGCILEGPEPSQLKPLV-IQA 409 (462) T ss_dssp TTCCSHHHHHHHHHHHHHHHTTT--THHHHHHHHHHHHTTC------SSHHHHHHHHHHHHHTSSSSCTTTTCTTT-TTH T ss_pred CCCCCHHHHHHHHHHHHHHhccC--ccHHhHHHHHHHhccC------CCHHHHHHHHHHHHHHHhCCCHHHHHHHH-HHH Confidence 445667777777777654111 0111234444455544 3677888999999988764332 111111 235 Q NP_000290.2 685 LNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 685 L~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) ++.+...+.+. ++.++..++.++..++.... T Consensus 410 ~~~l~~~l~d~-~~~vr~~a~~~l~~l~~~~~ 440 (462) T 1IBR_B 410 MPTLIELMKDP-SVVVRDTAAWTVGRICELLP 440 (462) T ss_dssp HHHHHHGGGCS-CHHHHHHHHHHHHHHHHHGG T ss_pred HHHHHHHcCCC-CHHHHHHHHHHHHHHHHhCh Confidence 66677777665 78899999999998876443 No 407 >1B3U_A PROTEIN PHOSPHATASE PP2A, 65 KD; SCAFFOLD PROTEIN, PP2A, PHOSPHORYLATION, HEAT; 2.3A {Homo sapiens} SCOP: a.118.1.2 Probab=80.14 E-value=0.12 Score=50.76 Aligned_cols=109 Identities=15% Similarity=0.181 Sum_probs=67.7 Template_Neff=13.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.+..++. +.++.++..++.++..+...... .. ....+++.+...+.+.++.++..++.++..+.... T Consensus 242 ~~~~~l~~~l~-~~~~~~r~~~~~~l~~~~~~~~~-------~~-~~~~~~~~l~~~l~~~~~~~r~~a~~~l~~l~~~~ 312 (588) T 1B3U_A 242 LVMPTLRQAAE-DKSWRVRYMVADKFTELQKAVGP-------EI-TKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENL 312 (588) T ss_dssp HTHHHHHHHHT-CSSHHHHHHHHHTHHHHHHHHCH-------HH-CCCCCHHHHHHHHTCSSHHHHHHHHHHHHHHHHTS T ss_pred HHHHHHHHHHh-CCCHHHHHHHHhhHHHHHHHHCC-------CC-CHHhHHHHHHHHhccCHHHHHHHHHHHHHHHHHhC Confidence 35566666776 46777888888888888754221 11 12456677777777777888889999988887641 Q NP_000290.2 627 -LL-H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 627 -e~-~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) .. . ......+++.+...+.+ .+..++..++.++..+.. T Consensus 313 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~~~~~l~~l~~ 353 (588) T 1B3U_A 313 SADCRENVIMSQILPCIKELVSD------ANQHVKSALASVIMGLSP 353 (588) T ss_dssp CTTTHHHHCCCCCHHHHHHHHTC------SCHHHHHHHHTTGGGGHH T ss_pred CcchhhhhhHHhHHHHHHHHhcC------CCHHHHHHHHHHHHHHHH Confidence 11 1 11113345555555554 245666667777666654 No 408 >4P6Z_G BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=80.03 E-value=0.13 Score=52.92 Aligned_cols=67 Identities=18% Similarity=0.165 Sum_probs=48.8 Template_Neff=12.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) +++.+..++. +.++.++..++.+|..+....+. . ...+++.|...+.+.++.++..++.++..++.. T Consensus 152 ~~~~l~~~l~-~~~~~vr~~a~~~L~~l~~~~~~--------~--~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~ 218 (627) T 4P6Z_G 152 LAGEVEKLLK-TSNSYLRKKAALCAVHVIRKVPE--------L--MEMFLPATKNLLNEKNHGVLHTSVVLLTEMCER 218 (627) T ss_dssp HHHHHHHHHT-CSCHHHHHHHHHHHHHHHHHCSG--------G--GGGGHHHHTTCTTCCCHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHhh-CCCHHHHHHHHHHHHHHHHHCHH--------H--HHHHHHHHHHHHhCCCHHHHHHHHHHHHHHHHh Confidence 4666777777 46778888899999888764221 1 135677777888777888888898888888654 No 409 >5NR4_A CLIP-associating protein 2; Microtubules, TOG domain, Tubulin, Structural; 1.198A {Homo sapiens} Probab=79.96 E-value=0.12 Score=44.07 Aligned_cols=109 Identities=12% Similarity=0.062 Sum_probs=69.2 Template_Neff=12.900 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.++.++..++.++..+........... ...+++.+...+.+.+..++..++.++..+...... T Consensus 51 ~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~~--- 126 (230) T 5NR4_A 51 GKTVDALTGWVGSSNYRVSLMGLEILSAFVDRLSTRFKSY-VAMVIVALIDRMGDAKDKVRDEAQTLILKLMDQVAP--- 126 (230) T ss_dssp HHHHHHHHHHHHCSSHHHHHHHHHHHHHHHHHHGGGGGGG-HHHHHHHHHHHTTCSSHHHHHHHHHHHHHHHHHTSC--- T ss_pred HHHHHHHHHHHcCCCHHHHHHHHHHHHHHHHHhhHHHHHH-HHHHHHHHHHHhccCCHHHHHHHHHHHHHHHHcCCC--- Confidence 3455666666666778888889999888876543221111 134566666666666677788888888777653210 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...+++.+...+. +.++.++..++.++..++.. T Consensus 127 ---~~~~~~~l~~~l~-~~~~~~r~~~~~~l~~l~~~ 159 (230) T 5NR4_A 127 ---PMYIWEQLASGFK-HKNFRSREGVCLCLIETLNI 159 (230) T ss_dssp ---HHHHHHHHGGGGG-CSCHHHHHHHHHHHHHHHHH T ss_pred ---HHHHHHHHHhcCC-CCCHHHHHHHHHHHHHHHHH Confidence 1234555555665 45667888888888877753 No 410 >2P8Q_A Importin beta-1 subunit, Snurportin-1; HEAT repeat, IBB-domain, Importin, Karyopherin; 2.35A {Homo sapiens} SCOP: a.118.1.1 Probab=79.89 E-value=0.12 Score=54.05 Aligned_cols=154 Identities=11% Similarity=0.064 Sum_probs=92.1 Template_Neff=13.100 Q NP_000290.2 548 AIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsnLa 623 (747) .++.|...+. +.+ +.++..++.+|..++..... . .... ....+++.+...+.+.+ +.++..++.++..++ T Consensus 129 l~~~l~~~l~-~~~~~~~~~~~~~~~l~~l~~~~~~---~-~~~~-~~~~l~~~l~~~l~~~~~~~~vr~~a~~~l~~l~ 202 (876) T 2P8Q_A 129 LIPQLVANVT-NPNSTEHMKESTLEAIGYICQDIDP---E-QLQD-KSNEILTAIIQGMRKEEPSNNVKLAATNALLNSL 202 (876) T ss_dssp HHHHHHHHHH-CTTCCHHHHHHHHHHHHHHHHHSCT---T-SSST-THHHHHHHHHHHHCTTCSCHHHHHHHHHHHHHHG T ss_pred HHHHHHHHhh-CCCCCHHHHHHHHHHHHHHHHhcCH---H-HHHH-HHHHHHHHHHHHHhCCCCCHHHHHHHHHHHHHHH Confidence 4566666666 344 56777888888877754221 0 0011 12456677777777665 788888999998887 Q NP_000290.2 624 RH-PLL-H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 624 ~~-~e~-~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) .. ... . ......+++.+...+.+ .++.++..++.+|..+...............+++.+...+.+. ++.+ T Consensus 203 ~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~~~~~~~~~~~~~l~~~l~~~l~~~-~~~v 275 (876) T 2P8Q_A 203 EFTKANFDKESERHFIMQVVCEATQC------PDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSD-IDEV 275 (876) T ss_dssp GGCHHHHTCHHHHHHHHHHHHHHTTC------SSHHHHHHHHHHHHHHHHHCGGGTHHHCCCCCHHHHHHHHTCS-SHHH T ss_pred HHchhhccCHHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhcHHHHHHhhhHHHHHHHHHHhcCC-hHHH Confidence 64 111 1 11122344455555544 3567888899999888764332222112223566666667655 6778 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..+... T Consensus 276 ~~~a~~~l~~l~~~ 289 (876) T 2P8Q_A 276 ALQGIEFWSNVCDE 289 (876) T ss_dssp HHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH Confidence 88888888777653 No 411 >4I5L_D PP2A A alpha subunit (9-589); EF Hand, Phosphatase, CDC6 (Substrate); HET: FGA, ACB, DAL, MLI, PEG, 1ZN, MAA; 2.43A {Microcystis aeruginosa} Probab=79.88 E-value=0.12 Score=50.59 Aligned_cols=147 Identities=14% Similarity=0.094 Sum_probs=80.2 Template_Neff=13.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.+...+. +.++.++..++.++..+...... .. .....++.+...+.+.++.++..++.++..+.... T Consensus 320 ~~~~~l~~~l~-~~~~~vr~~~~~~l~~l~~~~~~------~~--~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~ 390 (584) T 4I5L_D 320 QILPCIKELVS-DANQHVKSALASVIMGLSPILGK------DN--TIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVI 390 (584) T ss_dssp CCHHHHHHHHT-CSCHHHHHHHHTTGGGGHHHHHH------HH--CCCCCHHHHHHHHTCSCHHHHHHHHTCCHHHHHHS T ss_pred hHHHHHHHHcc-CCCHHHHHHHHHHHHHHHHHhCC------cc--hHHHHHHHHHHHhcCCCHHHHHHHHHcHHHHHHHc Confidence 45666666776 35667777888888777653211 11 12345666677777777778888888887776541 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .... ....+++.+...+.+ .+..++..++.++..+....+. ......+++.+..++.+. ++.++..++. T Consensus 391 ~~~~-~~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~---~~~~~~~~~~l~~~l~~~-~~~vr~~a~~ 459 (584) T 4I5L_D 391 GIRQ-LSQSLLPAIVELAED------AKWRVRLAIIEYMPLLAGQLGV---EFFDEKLNSLCMAWLVDH-VYAIREAATS 459 (584) T ss_dssp CHHH-HHHHHHHHHHHHHTC------SSHHHHHHHHHHHHHHHHHHCH---HHCCCCCHHHHHHHTTCS-SHHHHHHHHH T ss_pred ChHH-HHHhHHHHHHHHHHh------CCHHHHHHHHHHHHHHHHhcCh---HHhHHHHHHHHHHHHcCC-HHHHHHHHHH Confidence 1111 112244445555544 2456666677777666543111 111112344444555444 5556666666 Q NP_000290.2 707 LLSDMWS 713 (747) Q Consensus 707 aLsnL~~ 713 (747) +|..+.. T Consensus 460 ~l~~l~~ 466 (584) T 4I5L_D 460 NLKKLVE 466 (584) T ss_dssp HHHHHHH T ss_pred HHHHHHH Confidence 6666554 No 412 >1QGR_A IMPORTIN BETA SUBUNIT, IMPORTIN ALPHA-2; TRANSPORT RECEPTOR, NUCLEAR IMPORT, HEAT; 2.3A {Homo sapiens} SCOP: a.118.1.1 Probab=79.85 E-value=0.12 Score=54.15 Aligned_cols=154 Identities=11% Similarity=0.065 Sum_probs=92.3 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsnLa 623 (747) .++.|...+. +.+ +.++..++.+|..++..... . .... ....+++.+...+.+.+ +.++..++.+|..++ T Consensus 129 ~~~~l~~~l~-~~~~~~~~~~~~l~~l~~l~~~~~~---~-~~~~-~~~~l~~~l~~~l~~~~~~~~vr~~a~~~l~~l~ 202 (876) T 1QGR_A 129 LIPQLVANVT-NPNSTEHMKESTLEAIGYICQDIDP---E-QLQD-KSNEILTAIIQGMRKEEPSNNVKLAATNALLNSL 202 (876) T ss_pred HHHHHHHHHc-CCCCCHHHHHHHHHHHHHHHhhCCH---H-HHHH-HHHHHHHHHHHHhcCCCCCHHHHHHHHHHHHHHH Confidence 4556666666 344 56777888888877754221 0 0111 12356677777777655 788888999998887 Q NP_000290.2 624 RHP-LL-H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 624 ~~~-e~-~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) ... .. . ......+++.+...+.+ .++.++..++.+|..++..............+++.+...+.+. ++.+ T Consensus 203 ~~~~~~~~~~~~~~~i~~~l~~~~~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~l~~~l~~~l~~~-~~~v 275 (876) T 1QGR_A 203 EFTKANFDKESERHFIMQVVCEATQC------PDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSD-IDEV 275 (876) T ss_pred hhCCcccCChHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHhCHHHhhHhhHHhHHHHHHHHhCCC-CHHH Confidence 652 11 1 11122344455555544 3577888899999888765332222111223566666667655 6778 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..++.. T Consensus 276 ~~~a~~~l~~l~~~ 289 (876) T 1QGR_A 276 ALQGIEFWSNVCDE 289 (876) T ss_pred HHHHHHHHHHHHHH Confidence 88888888777654 No 413 >1B3U_A PROTEIN PHOSPHATASE PP2A, 65 KD; SCAFFOLD PROTEIN, PP2A, PHOSPHORYLATION, HEAT; 2.3A {Homo sapiens} SCOP: a.118.1.2 Probab=79.78 E-value=0.12 Score=50.60 Aligned_cols=146 Identities=14% Similarity=0.095 Sum_probs=76.6 Template_Neff=13.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.+...+. +.++.++..++.++..+...... . . .....++.+...+.+.++.++..++.++..+.... T Consensus 324 ~~~~~l~~~l~-~~~~~vr~~~~~~l~~l~~~~~~------~-~-~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~~ 394 (588) T 1B3U_A 324 QILPCIKELVS-DANQHVKSALASVIMGLSPILGK------D-N-TIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVI 394 (588) T ss_dssp CCHHHHHHHHT-CSCHHHHHHHHTTGGGGHHHHCH------H-H-CCCCCHHHHHHHHTCSCHHHHHHHHTTCHHHHHHS T ss_pred hHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHHCc------c-c-hHHhHHHHHHHHhcCCCHHHHHHHHhchHHHHHhc Confidence 45566666676 35667777888888777653211 1 1 11345666677777777778888888887776541 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .... ....+++.+...+.+ .+..++..++.++..+....+. ......+++.+..++.+. +..++..++. T Consensus 395 ~~~~-~~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~---~~~~~~~~~~l~~~l~~~-~~~vr~~a~~ 463 (588) T 1B3U_A 395 GIRQ-LSQSLLPAIVELAED------AKWRVRLAIIEYMPLLAGQLGV---EFFDEKLNSLCMAWLVDH-VYAIREAATS 463 (588) T ss_dssp CHHH-HHHHHHHHHHHHHTC------SSHHHHHHHHHHHHHHHHHHCG---GGCCHHHHHHHHHGGGCS-SHHHHHHHHH T ss_pred CHHH-HHHHHHHHHHHHHhc------CCHHHHHHHHHHHHHHHHhcCh---HHhHHHHHHHHHHHhcCC-hHHHHHHHHH Confidence 1111 111234444444444 2455666666666666542111 111112333444444433 4455555555 Q NP_000290.2 707 LLSDMW 712 (747) Q Consensus 707 aLsnL~ 712 (747) +|..+. T Consensus 464 ~l~~l~ 469 (588) T 1B3U_A 464 NLKKLV 469 (588) T ss_dssp HHHHHH T ss_pred HHHHHH Confidence 555544 No 414 >6MZE_Z Tubulin alpha-1A chain, Tubulin beta; Microtubule, Tubulin, Tubulin polymerization, Heat; HET: MG, GTP, GDP; 3.6A {Sus scrofa} Probab=79.70 E-value=0.13 Score=50.52 Aligned_cols=152 Identities=11% Similarity=0.094 Sum_probs=94.5 Template_Neff=12.900 Q NP_000290.2 550 RTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIAR-LLQSGNSDVVRSGASLLSNMSRHPLL 628 (747) Q Consensus 550 ~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~-LL~s~d~eVr~~AL~aLsnLa~~~e~ 628 (747) +.+...+. +.++.++..++.+|..++..... ........ ....+++.|+. ++.+.++.++..++.+|..+...... T Consensus 57 ~~l~~~l~-d~~~~vr~~a~~~l~~l~~~~~~-~~~~~~~~-~~~~~l~~l~~~~~~~~~~~vr~~a~~~l~~l~~~~~~ 133 (536) T 6MZE_Z 57 ELFASYIV-DSNVVAQENAIIALHTLLEYISQ-VPNVSTSK-LRLQWIPPLVEKGLSSSRAATKAKATDCIMLLTQSDTS 133 (536) T ss_dssp HHHHHHHS-CSSHHHHHHHHHHHHHHHHHTSS-SCCTTHHH-HHHHHHHHHCCCCCSCSCHHHHHHHHHHHHHHHHHSSS T ss_pred HHHHHHhc-CchHHHHHHHHHHHHHHHHHhcc-CCCCCcHH-HHHhhHHHHHHhhccCCCHHHHHHHHHHHHHHhccCcc Confidence 55666676 47788899999999888754211 00000011 12345666776 56667788899999999888764111 Q NP_000290.2 629 HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAK---QYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 629 ~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~---~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+...+.+ .++.++..++.+|..++........ ......+++.+...+.+. ++.++..++ T Consensus 134 ----~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~vr~~a~ 202 (536) T 6MZE_Z 134 ----IQQTVNLMLPSLSN------KLPRLVSSCVKCLATIIEEFGFINVSDINILLSEILEPLPKLSSHA-DRNVRSETM 202 (536) T ss_dssp ----SHHHHHHHSGGGGC------SCHHHHHHHHHHHHHHHHTTCSCSCTTHHHHHHHHHTTHHHHHTCS-SHHHHHHHH T ss_pred ----HHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHHHhCCCcccccccchHHHHHHHHHHhcCC-CHHHHHHHH Confidence 11244555555554 3678888899999888764222110 001234567777777766 788999999 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .++..+.... T Consensus 203 ~~l~~l~~~~ 212 (536) T 6MZE_Z 203 NLILQIYKWF 212 (536) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 9988887543 No 415 >5F0N_A cohesin subunit Pds5, KLTH0D07062p; heat repeat cohesin subunit, cell; 3.2A {Lachancea thermotolerans} Probab=79.14 E-value=0.17 Score=59.20 Aligned_cols=150 Identities=8% Similarity=0.095 Sum_probs=100.7 Template_Neff=8.200 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.|...|. +++..+|..|+.+|+.+....+. .. ... .....++.++..+.+.++.++..++.++..+.... T Consensus 271 ~vlp~L~~~L~-~~d~~vR~~Av~~Lg~l~~~~~~--~~-l~~--~~~~l~~~ll~rl~D~~~~VR~~av~~L~~i~~~~ 344 (1175) T 5F0N_A 271 SVTGLLYQLLC-SDNELFRESATKCVSKMLGTHSL--IN-FAV--AHSDTYKIWLSKMADISPHVRQAWVSEIPSILMSR 344 (1175) T ss_dssp GGHHHHHHHTT-CSSHHHHHHHHHHHHHHHTSCCS--SC-HHH--HTHHHHHHHHGGGSCSCHHHHHHHHTTHHHHHHHC T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHHHccccc--cc-HHH--HcHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHcC Confidence 36777888887 47788999999999988753210 00 011 12346667777788888999999999999887641 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .. ....+++.|...+.+ .++.++..++.+|..+..... .........++.|...+.+. ++.+|..|+. T Consensus 345 ~~---l~~~ii~~L~~~L~D------~d~~VR~~av~~L~~l~~~~~--~~~~~~~~ll~~L~~~l~D~-~~~VR~~A~~ 412 (1175) T 5F0N_A 345 SD---LSDDISKGLAKALID------SDHTVRLSAIQTFHEVPVKRL--WECLPNAAVFAGLVHLTRET-RRDLRDECID 412 (1175) T ss_dssp SS---CHHHHHHHHHHHHTC------SSHHHHHHHHGGGTSSCHHHH--HHHCCCHHHHHHHHTTTTCC-SHHHHHHHHH T ss_pred hh---hHHHHHHHHHHHhCC------CCHHHHHHHHHHHHhhhhhhh--hhcCCchHHHHHHHHHHhcC-CHHHHHHHHH Confidence 11 112355666666766 378899999999988764311 01111134567777777776 7889999999 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) +|+.+... T Consensus 413 aL~~l~~~ 420 (1175) T 5F0N_A 413 AVARIYTE 420 (1175) T ss_dssp HHHHHHHH T ss_pred HHHHHHHH Confidence 98887754 No 416 >4NEE_G AP-2 complex subunit sigma, AP-2; clathrin Adaptor AP-2, HIV-1 Nef; 2.8841A {Rattus norvegicus} Probab=78.80 E-value=0.15 Score=48.94 Aligned_cols=115 Identities=12% Similarity=0.097 Sum_probs=71.6 Template_Neff=12.000 Q NP_000290.2 548 AIRTYLNLM--GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL--~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+..++ . +.++.++..++.+|..+....+. .+....+++.|...+.+.++.++..++.+|..+... T Consensus 149 ~~~~l~~~l~~~-~~~~~vr~~a~~~L~~l~~~~~~--------~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 219 (398) T 4NEE_G 149 FAGEIPKILVAG-DTMDSVKQSAALCLLRLYRTSPD--------LVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQK 219 (398) T ss_dssp HTTHHHHHHHCS-SSCHHHHHHHHHHHHHHHHHCGG--------GSCCSSHHHHHHGGGGCSCHHHHHHHHHHHHHHHHH T ss_pred HHHhHHHHHhcC-CCCHHHHHHHHHHHHHHHHHChh--------hccccchHHHHHHHhcCCCHHHHHHHHHHHHHHHHh Confidence 455666777 6 46778888999999988764221 111245677788888777888999999999988865 Q NP_000290.2 626 PL-LHRVMGNQVFPEVTRLLTSHTG-------NTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 626 ~e-~~~ll~~giI~~Ll~LL~s~s~-------~~~~d~eVr~~Al~aLsnLa~~ 671 (747) .. ........+++.+..++.+... ....++.++..++.+|..+... T Consensus 220 ~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~~~~~ 273 (398) T 4NEE_G 220 NPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPP 273 (398) T ss_dssp CGGGGTHHHHHHHHHHHHHHHCCTTTTGGGEETTEESHHHHHHHHHHHTTSCSC T ss_pred CHHHHHHHHHHHHHHHHHHHhcCCcCcccccccCCCCHHHHHHHHHHHHhCCCC Confidence 21 1111112345555555543000 0001456777888888887754 No 417 >3W3U_A Importin subunit beta-3; HEAT repeat, nuclear import, PROTEIN; 2.6A {Saccharomyces cerevisiae} Probab=78.75 E-value=0.14 Score=55.16 Aligned_cols=158 Identities=8% Similarity=0.034 Sum_probs=93.7 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..++..... ..... ...+++.|...+.+.++.++..++.+|+.++.... T Consensus 849 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 921 (1078) T 3W3U_A 849 IWPMINTFLL-DNEPILVIFALVVIGDLIQYGGE-----QTASM-KNAFIPKVTECLISPDARIRQAASYIIGVCAQYAP 921 (1078) T ss_dssp GHHHHHHHHT-SSCHHHHHHHHHHHHHHHHHHGG-----GCHHH-HHHHHHHHHHHHTCSCHHHHHHHHHHHHHHHHHSC T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhcch-----hhHHH-HHhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHCc Confidence 3444555555 35667777888888887754221 01111 23567777888888888999999999999887621 Q NP_000290.2 628 -LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 628 -~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) ........+++.|...+.........+..++..++.+|..+....+.... ....+++.++..+....++.++..++. T Consensus 922 ~~~~~~~~~~l~~l~~~l~~~~~~~~~~~~vr~~a~~~l~~l~~~~~~~~~--~~~~~~~~l~~~l~~~~~~~~~~~~~~ 999 (1078) T 3W3U_A 922 STYADVCIPTLDTLVQIVDFPGSKLEENRSSTENASAAIAKILYAYNSNIP--NVDTYTANWFKTLPTITDKEAASFNYQ 999 (1078) T ss_dssp TTTHHHHHHHHHHHHHHTC-CCTTSHHHHHHHHHHHHHHHHHHHHC--------CCHHHHHHHTTCCCCSCHHHHHHHHH T ss_pred cccHHhHHHHHHHHHHHHhCCCcccccccchHHHHHHHHHHHHHHcccCCC--ChhHHHHHHHHhCCcCCCHHHHHHHHH Confidence 11111134566666666510000003678899999999998875332211 122456666666632226677888888 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) +|..++.. T Consensus 1000 ~l~~l~~~ 1007 (1078) T 3W3U_A 1000 FLSQLIEN 1007 (1078) T ss_dssp HHHHHHHT T ss_pred HHHHHHHc Confidence 88877754 No 418 >4NEE_B AP-2 complex subunit sigma, AP-2; clathrin Adaptor AP-2, HIV-1 Nef; 2.8841A {Rattus norvegicus} Probab=78.75 E-value=0.15 Score=49.03 Aligned_cols=115 Identities=12% Similarity=0.097 Sum_probs=71.5 Template_Neff=11.900 Q NP_000290.2 548 AIRTYLNLM--GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL--~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+..++ . +.++.++..++.+|..+....+. .+....+++.|...+.+.++.++..++.+|..+... T Consensus 149 ~~~~l~~~l~~~-~~~~~vr~~a~~~L~~l~~~~~~--------~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 219 (398) T 4NEE_B 149 FAGEIPKILVAG-DTMDSVKQSAALCLLRLYRTSPD--------LVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQK 219 (398) T ss_pred HHHHHHHHHcCC-CCCHHHHHHHHHHHHHHHHHChh--------HhcHhhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHh Confidence 455666777 6 46778888999999988764221 111245677788888777888999999999988865 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTG-------NTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~-------~~~~d~eVr~~Al~aLsnLa~~ 671 (747) ... .......+++.+..++.+... ....++.++..++.+|..+... T Consensus 220 ~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~a~~~l~~~~~~ 273 (398) T 4NEE_B 220 NPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPP 273 (398) T ss_pred CHHHhHHHHHHHHHHHHHHHcCCCCCCccccccCCCCHHHHHHHHHHHHhhccC Confidence 211 111112345555555543000 0001456777888888887754 No 419 >3DAD_A FH1/FH2 domain-containing protein 1; Formin, FHOD1, GTPase-binding domain, ubiquitin-superfold; 2.3A {Homo sapiens} Probab=78.49 E-value=0.18 Score=50.49 Aligned_cols=154 Identities=13% Similarity=0.081 Sum_probs=94.1 Template_Neff=8.200 Q NP_000290.2 565 LEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVM-GNQVFPEVTR 642 (747) Q Consensus 565 r~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll-~~giI~~Ll~ 642 (747) ...++..|..++..... ....|++.+++..|+.++...+......++.+|..|...... ..++ ....+..|.. T Consensus 135 l~~~L~~L~~~l~~d~~-----wv~eFi~~~Gl~~L~~~l~~~~~~~~~~~L~cl~~Lm~~~~G~~~v~~~~~~i~~l~~ 209 (339) T 3DAD_A 135 LRRSLFSLKQIFQEDKD-----LVPEFVHSEGLSCLIRVGAAADHNYQSYILRALGQLMLFVDGMLGVVAHSDTIQWLYT 209 (339) T ss_dssp HHHHHHHHHHHHHTCTT-----HHHHHHHTTHHHHHHHHHTTSCHHHHHHHHHHHHHHTTSHHHHHHHHHCHHHHHHHHH T ss_pred HHHHHHHHHHHHhCCcc-----HHHHHHHCCHHHHHHHHHHHccHHHHHHHHHHHHHHHhCHHHHHHHHhCHHHHHHHHH Confidence 34566666666521121 345557788999999999876666777888888888776222 2222 2346677777 Q NP_000290.2 643 LLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFS----------SSMLNNIINLCRSS--ASPKAAEAARLLLSD 710 (747) Q Consensus 643 LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve----------~giL~~Ll~LL~s~--~d~eVr~aAL~aLsn 710 (747) .+.+ ....++..++.+|..++...+.....+.+ ...+..++..+... .+.+++..++.++.. T Consensus 210 ~l~s------~~~~v~~~al~iL~~l~~~~~~g~~~Vl~al~~~~~~~~~~~f~~lv~~L~~~~~~d~e~~~~~L~LINa 283 (339) T 3DAD_A 210 LCAS------LSRLVVKTALKLLLVFVEYSENNAPLFIRAVNSVASTTGAPPWANLVSILEEKNGADPELLVYTVTLINK 283 (339) T ss_dssp GGGC------SCHHHHHHHHHHHHHHHHHCGGGHHHHHHHHHHHHHHHCCCTTHHHHHHHTTTTSCCHHHHHHHHHHHHH T ss_pred HhcC------CCHHHHHHHHHHHHHHHhcCCCcHHHHHHHHHhHHHhhCCCCHHHHHHHHHhhCCCCHHHHHHHHHHHHH Confidence 7765 35678888888888887654333222222 23466677777642 156677777777777 Q NP_000290.2 711 MWSSKE-------LQGVLRQQGFDRN 729 (747) Q Consensus 711 L~~~~~-------~~~~~~~~~~~~~ 729 (747) |+.... +..-|.+.|+..- T Consensus 284 Ll~~~~d~~~R~~lr~~L~~~Gi~~i 309 (339) T 3DAD_A 284 TLAALPDQDSFYDVTDALEQQGMEAL 309 (339) T ss_dssp HHHHCSSHHHHHHHHHHHHHTTHHHH T ss_pred HHHcCCCHHHHHHHHHHHHHCChHHH Confidence 664433 3344555665443 No 420 >5VJC_A Protein mini spindles; TOG, HEAT Repeat, Tubulin, CELL; 2.0A {Drosophila melanogaster} Probab=78.36 E-value=0.16 Score=46.47 Aligned_cols=73 Identities=11% Similarity=0.004 Sum_probs=44.8 Template_Neff=11.400 Q NP_000290.2 546 SDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) ....+.+...+. +.++.++..++..|..++..... ..... -..++..+...+.+.++.++..++.++..++.. T Consensus 49 ~~~~~~l~~~l~-~~~~~~r~~a~~~L~~~~~~~~~-----~~~~~-~~~l~~~l~~~l~d~~~~v~~~a~~~l~~l~~~ 121 (271) T 5VJC_A 49 ANVNKALIANMF-HDDFRYHLKVIEQLSEDLAGNSK-----ALVCN-LDLILKWLTLRFYDTNPSVLIKGLEYLVQVFQV 121 (271) T ss_dssp TTCCHHHHHHHT-CSSHHHHHHHHHHHHHHTTTCHH-----HHHHT-HHHHHHHHHHHTSSCCHHHHHHHHHHHHHHHHH T ss_pred hcCCHHHHHhcc-CCCHHHHHHHHHHHHHHHhcChH-----HHHHH-HHHHHHHHHHHHhCCCHHHHHHHHHHHHHHHHH Confidence 334566777776 46778888888888888764321 01111 123344444555566777888888888877654 No 421 >5WBJ_A Regulatory-associated protein of TOR 1,Eukaryotic; Raptor, TOS, PROTEIN BINDING; 3.0A {Arabidopsis thaliana} Probab=78.29 E-value=0.18 Score=59.27 Aligned_cols=156 Identities=10% Similarity=0.095 Sum_probs=112.5 Template_Neff=8.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) .++.+++.|.+ +..+..|+..|..++..... ....+...++++.++.+|.+..++++..++.++++++.. + T Consensus 467 qLp~~lq~L~s---~~~r~rAL~~L~~~ld~~~~-----~~~~~~~~gi~p~ll~lL~s~~~~lr~~a~~i~a~i~~~d~ 538 (1287) T 5WBJ_A 467 QLPIVLQVLLS---QCHRFRALVLLGRFLDMGSW-----AVDLALSVGIFPYVLKLLQTTTNELRQILVFIWTKILALDK 538 (1287) T ss_dssp CHHHHHHHTTS---STTHHHHHHHHHHHHTTCHH-----HHHHHHHHTCHHHHHHGGGCCCHHHHHHHHHHHHHHHHHCG T ss_pred HHHHHHHHHcC---HHHHHHHHHHHHHHHhcCHH-----HHHHHHHCCcHHHHHHHHcCCCHHHHHHHHHHHHHHHccCH Confidence 46666777752 23677899999998874332 234445679999999999988889999999999999876 3 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR-------SSASP 698 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~-------s~~d~ 698 (747) .. ..++..+.+..|+.+|.... ..+.++..++.+|+.++...+.....+...+++..+...+. +. ++ T Consensus 539 ~~q~~l~~~~~l~~ll~~L~~~~----~~~~~r~~a~~~Ls~l~~~~~~~~~~~~~~~~l~~l~~~L~~~~~~~~~~-~~ 613 (1287) T 5WBJ_A 539 SCQIDLVKDGGHTYFIRFLDSSG----AFPEQRAMAAFVLAVIVDGHRRGQEACLEANLIGVCLGHLEASRPSDPQP-EP 613 (1287) T ss_dssp GGHHHHHHTTCHHHHHHHHHCSS----CCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHCC----------CH T ss_pred HHHHHHHHcCCeeeEEEeecCCC----CCHHHHHHHHHHHHHHHcCCHhHHHHHHHCcHHHHHHHHHHhcCCCCCCC-CH Confidence 33 34455667888888886420 23556778899999998765555555555577788877776 34 67 Q NP_000290.2 699 KAAEAARLLLSDMWSSKE 716 (747) Q Consensus 699 eVr~aAL~aLsnL~~~~~ 716 (747) .++..++.+|..|+...+ T Consensus 614 ~lr~~a~~~L~~L~~~~~ 631 (1287) T 5WBJ_A 614 LFLQWLCLCLGKLWEDFM 631 (1287) T ss_dssp HHHHHHHHHHHHHHTTCH T ss_pred HHHHHHHHHHHHHHhccH Confidence 889999999999986654 No 422 >5WBK_A Regulatory-associated protein of TOR 1,Ribosomal; Raptor, TOS, PROTEIN BINDING; 3.11A {Arabidopsis thaliana} Probab=78.26 E-value=0.18 Score=59.26 Aligned_cols=156 Identities=10% Similarity=0.095 Sum_probs=112.8 Template_Neff=8.700 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) .++.+++.|.+ +..+..|+..|..++..... ....+...++++.|+.+|.+..++++..++.++++++.. + T Consensus 467 ~Lp~~lq~L~s---~~~r~rAL~~L~~~ld~~~~-----a~~~~l~~Gi~p~ll~lL~s~~~~lr~~a~~i~a~i~~~d~ 538 (1287) T 5WBK_A 467 QLPIVLQVLLS---QCHRFRALVLLGRFLDMGSW-----AVDLALSVGIFPYVLKLLQTTTNELRQILVFIWTKILALDK 538 (1287) T ss_dssp SHHHHHHHHTS---GGGHHHHHHHHHHHHTTCHH-----HHHHHHHHTCHHHHHHGGGCCCHHHHHHHHHHHHHHHHHCG T ss_pred HHHHHHHHHcC---HHHHHHHHHHHHHHHhcCHH-----HHHHHHHCCcHHHHHHHHcCCCHHHHHHHHHHHHHHHccCH Confidence 46666777752 23677899999998874332 233445679999999999988889999999999999876 3 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCR-------SSASP 698 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~-------s~~d~ 698 (747) .. ..++..+.+..|+.+|.... ..+.++..++.+|+.++...+.....+.+.+++..+...|. +. ++ T Consensus 539 ~~q~~l~~~~~l~~ll~~L~~~~----~~~~~r~~a~~~Ls~l~~~~~~~~~~~~~~~~l~~l~~~L~~~~~~~~~~-~~ 613 (1287) T 5WBK_A 539 SCQIDLVKDGGHTYFIRFLDSSG----AFPEQRAMAAFVLAVIVDGHRRGQEACLEANLIGVCLGHLEASRPSDPQP-EP 613 (1287) T ss_dssp GGHHHHHHTTTHHHHHHHHHSSC----CCHHHHHHHHHHHHHHHTTCHHHHHHHHHTTHHHHHHHHCC----------CH T ss_pred HHHHHHHHcCCeeeEEEeecCCC----CCHHHHHHHHHHHHHHHcCCHhHHHHHHHCcHHHHHHHHHHhcCCCCCCC-CH Confidence 33 34455667788888886420 23556778889999998765555555555577888877776 34 68 Q NP_000290.2 699 KAAEAARLLLSDMWSSKE 716 (747) Q Consensus 699 eVr~aAL~aLsnL~~~~~ 716 (747) .++..++.+|..|+.... T Consensus 614 ~lr~~a~~~L~~L~~~~~ 631 (1287) T 5WBK_A 614 LFLQWLCLCLGKLWEDFM 631 (1287) T ss_dssp HHHHHHHHHHHHHHTTCH T ss_pred HHHHHHHHHHHHHHcccH Confidence 889999999999986654 No 423 >6EN4_C Splicing factor 3B subunit 3; Protein complex, splicing modulator, SPLICING; HET: BGZ; 3.08A {Homo sapiens} Probab=78.21 E-value=0.15 Score=53.32 Aligned_cols=154 Identities=10% Similarity=0.027 Sum_probs=92.8 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKK-DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d-~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .++.+...+.+ .+ +.++..++.+|..+....+. .... .-..+++.+...+.+.++.++..++.++..+.... T Consensus 192 ~~~~l~~~l~~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~i~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~ 264 (852) T 6EN4_C 192 LLPFLKAVCKS-KKSWQARHTGIKIVQQIAILMGC-----AILP-HLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAA 264 (852) T ss_pred HHHHHHHHHcC-CCCHHHHHHHHHHHHHHHhhCch-----hhcc-cHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHcC Confidence 34445555552 33 67888888888888754321 1111 12345677777777778889999999998887652 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. .......+++.+...+.+ ....++..++.+|..++...+..........+++.+...+.+. ++.++..++ T Consensus 265 ~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~vr~~a~ 337 (852) T 6EN4_C 265 TPYGIESFDSVLKPLWKGIRQ------HRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSP-DEEMKKIVL 337 (852) T ss_pred CHHHHHHHHHHHHHHHHHHhc------CCHHHHHHHHHHHHHHHhcCCHHHhHHHHHHHHHHHHHHhcCC-CHHHHHHHH Confidence 11 111112345666666654 2456777888888887764222111111124566666666655 677888888 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .++..++... T Consensus 338 ~~l~~l~~~~ 347 (852) T 6EN4_C 338 KVVKQCCGTD 347 (852) T ss_pred HHHHHHhhcC Confidence 8888877543 No 424 >5F0O_A cohesin subunit Pds5, KLTH0D07062p, KLTH0G16610p; heat repeat cohesin subunit, cell; 3.5A {Lachancea thermotolerans} Probab=78.20 E-value=0.18 Score=58.49 Aligned_cols=150 Identities=8% Similarity=0.096 Sum_probs=99.5 Template_Neff=8.400 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .+++.|...|. +.++.+|..|+.+|+.+...... .. .... ....++.++..+.+.++.++..++.++..+.... T Consensus 280 ~vlp~L~~~L~-~~d~~vR~~Av~~Lg~l~~~~~~--~~-l~~~--~~~l~~~ll~rl~D~~~~VR~~av~~l~~i~~~~ 353 (1133) T 5F0O_A 280 SVTGLLYQLLC-SDNELFRESATKCVSKMLGTHSL--IN-FAVA--HSDTYKIWLSKMADISPHVRQAWVSEIPSILMSR 353 (1133) T ss_dssp TSTTTTTTTTS-CSSHHHHHHHHHHHHHHHHSCCS--ST-TTTT--THHHHHHHHHTTSCSCHHHHHHHTTSHHHHHTTC T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHHHccccc--cc-HHHH--cHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHhcC Confidence 35677778887 47788899999999998653210 00 0111 1345666777778888999999999998887641 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) .. ....+++.|...+.+ .++.++..++.+|+.+..... .........++.|...+.+. ++.+|..|+. T Consensus 354 ~~---l~~~ii~~L~~~L~D------~d~~VR~~av~~L~~l~~~~~--~~~~~~~~ll~~L~~~l~D~-~~~VR~~A~~ 421 (1133) T 5F0O_A 354 SD---LSDDISKGLAKALID------SDHTVRLSAIQTFHEVPVKRL--WECLPNAAVFAGLVHLTRET-RRDLRDECID 421 (1133) T ss_dssp ST---THHHHHHHHHHTTSC------SSHHHHHHHHTHHHHSCHHHH--HHHCCCHHHHHHHHHGGGBS-SHHHHHHHHH T ss_pred hh---HHHHHHHHHHHHhCC------CCHHHHHHHHHHHhhcchhcH--hhcCCchHHHHHHHHHHhcC-CHHHHHHHHH Confidence 11 112355666666766 478899999999988764311 01111134567777777766 7888999999 Q NP_000290.2 707 LLSDMWSS 714 (747) Q Consensus 707 aLsnL~~~ 714 (747) +|+.+... T Consensus 422 aL~~l~~~ 429 (1133) T 5F0O_A 422 AVARIYTE 429 (1133) T ss_dssp HHHHHHHH T ss_pred HHHHHHHH Confidence 88887754 No 425 >2NYL_A Protein phosphatase 2, regulatory subunit; HEAT repeat, HYDROLASE-HYDROLASE INHIBITOR COMPLEX; HET: DAL, MSE, ACB, 1ZN, DAM, FGA; 3.8A {Homo sapiens} SCOP: a.118.1.2 Probab=77.79 E-value=0.16 Score=49.54 Aligned_cols=109 Identities=15% Similarity=0.189 Sum_probs=67.0 Template_Neff=13.500 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) ..++.+...+. +.++.++..++.++..+...... .. ....+++.+...+.+.++.++..++.++..+... T Consensus 236 ~~~~~l~~~l~-~~~~~vr~~~~~~l~~~~~~~~~-------~~-~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~~~~~~ 306 (582) T 2NYL_A 236 LVMPTLRQAAE-DKSWRVRYMVADKFTELQKAVGP-------EI-TKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENL 306 (582) T ss_dssp TTHHHHHHHHH-CSSHHHHHHHHHTHHHHHHHHCS-------HH-CCCCCHHHHHHHHTCSSHHHHHHHHTTHHHHHHTS T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHhHHHHHHHHCC-------CC-CHhhhHHHHHHHhcCChHHHHHHHHHHHHHHHHhC Confidence 35566666676 46777888888888887754221 11 1245667777777777788888999998888764 Q NP_000290.2 626 PLL-H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 626 ~e~-~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) ... . ......+++.+...+.+ .++.++..++.++..+.. T Consensus 307 ~~~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~~~~~l~~l~~ 347 (582) T 2NYL_A 307 SADCRENVIMSQILPCIKELVSD------ANQHVKSALASVIMGLSP 347 (582) T ss_dssp CTTTHHHHCCCCCHHHHHHHHTC------SCHHHHHHHHHHGGGGHH T ss_pred CCcchHHHHHHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHH Confidence 111 1 11112345555555554 245666667777666654 No 426 >3W3W_A Importin subunit beta-3, Protein STE12; HEAT repeat, nuclear import, PROTEIN; 2.2A {Saccharomyces cerevisiae} Probab=77.60 E-value=0.16 Score=54.65 Aligned_cols=157 Identities=9% Similarity=0.079 Sum_probs=90.3 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) +++.+...+. +.++.++..++.+|..++...+. .... ....+++.|...+.+.++.++..++.+|+.++.. + T Consensus 849 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 921 (1078) T 3W3W_A 849 IWPMINTFLL-DNEPILVIFALVVIGDLIQYGGE-----QTAS-MKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAP 921 (1078) T ss_dssp GHHHHHHHHC---CHHHHHHHHHHHHHHHTC--C-----CCHH-HHHHHHHHHHHHHTCSCHHHHHHHHHHHHHHHHHSS T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhcch-----hhHH-HHHhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHCc Confidence 3445555555 35667777888888888764221 1111 1245677778888888889999999999999876 2 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. ...+ ..+++.+...+.........+..++..++.+|..+....+.... ....+++.++..+....+..++..++ T Consensus 922 ~~~~~~~-~~~l~~l~~~l~~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~--~~~~~~~~l~~~l~~~~~~~~~~~~~ 998 (1078) T 3W3W_A 922 STYADVC-IPTLDTLVQIVDFPGSKLEENRSSTENASAAIAKILYAYNSNIP--NVDTYTANWFKTLPTITDKEAASFNY 998 (1078) T ss_dssp TTTHHHH-HHHHHHHHHHTC--CCSSGGGHHHHHHHHHHHHHHHHHTTTSCC----CHHHHHHHTTCCCCSCHHHHHHHH T ss_pred cchHhhH-HHHHHHHHHHHhCCCCcchhchhhHHHHHHHHHHHHHHcccCCC--chhHHHHHHHHhCCccCCHHHHHHHH Confidence 21 1112 34666677766521000003567888899999988765332111 12235566666664222567788888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..+... T Consensus 999 ~~l~~l~~~ 1007 (1078) T 3W3W_A 999 QFLSQLIEN 1007 (1078) T ss_dssp HHHHC---- T ss_pred HHHHHHHHc Confidence 888777654 No 427 >4LAC_A Serine/threonine-protein phosphatase 2A activator (E.C.5.2.1.8); PP2A, PTPA, protein phosphatase, signaling; HET: AGS, MES; 2.82A {Homo sapiens} Probab=77.52 E-value=0.17 Score=44.16 Aligned_cols=115 Identities=13% Similarity=-0.025 Sum_probs=73.8 Template_Neff=12.800 Q NP_000290.2 239 DIECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRS 318 (747) Q Consensus 239 ~~~~~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~ 318 (747) ........++.+...+.+.++.++..++..+..+....... .....+++.+...+.+.++.++..++.++..+.... T Consensus 27 ~~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~---~~~~~~~~~l~~~l~~~~~~vr~~~~~~l~~~~~~~ 103 (258) T 4LAC_A 27 CESMSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVE---RTRSELLPFIVELAEDAKWRVRLAIIEYMPLLAGQL 103 (258) T ss_pred CCCccccHHHHHHHHhcCCCHHHHHHHHHHHHHHHHccCHH---HHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHhC Confidence 33334456666777777777888888888888877543211 112345566666676777788888888888776543 Q NP_000290.2 319 TTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 319 ~~~~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) .. ......+++.+...+. +.++.++..++.++..+... T Consensus 104 ~~---~~~~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~ 141 (258) T 4LAC_A 104 GV---EYFDEKLNSLCMAWLV-DHVYAIREAATSNLKKLVEK 141 (258) T ss_pred CC---hHHHHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHc Confidence 22 1112245556666665 55677888888888887754 No 428 >6FT5_A A3_A3; alphaRep, artificial protein, chimera, bidomain; HET: GOL, SO4; 1.94A {synthetic construct} Probab=77.46 E-value=0.17 Score=47.66 Aligned_cols=60 Identities=17% Similarity=0.244 Sum_probs=30.0 Template_Neff=12.800 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) ..++.+...+. +.++.++..++.+|..+... ..++.+...+.+.++.++..++.++..+. T Consensus 54 ~~~~~l~~~l~-~~~~~vr~~a~~~L~~~~~~----------------~~~~~l~~~l~~~~~~vr~~a~~~l~~~~ 113 (409) T 6FT5_A 54 RAVEPLIKALK-DEDAWVRRAAADALGQIGDE----------------RAVEPLIKALKDEDGWVRQSAAVALGQIG 113 (409) T ss_pred chHHHHHHHhc-CCCHHHHHHHHHHHHHHcCc----------------hhHHHHHHHhcCCCHHHHHHHHHHHHhhC Confidence 34455555555 34555555666655554321 12233444444555556666666555544 No 429 >1F59_B IMPORTIN BETA-1/FXFG NUCLEOPORIN; Protein-protein complex, TRANSPORT PROTEIN RECEPTOR; 2.8A {Homo sapiens} SCOP: a.118.1.1 Probab=77.42 E-value=0.17 Score=48.11 Aligned_cols=158 Identities=12% Similarity=0.047 Sum_probs=88.7 Template_Neff=12.900 Q NP_000290.2 547 DAIRTYLNLMGKS-KKDATLEACAGALQNLTASKGLMSS-------GMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASL 618 (747) Q Consensus 547 G~I~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s~~~s~-------~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~a 618 (747) +.+..++.++.+. .++.++..|+.+|.++...... .. ......-....+++.|+..+.+.... +..++.+ T Consensus 35 ~~~~~l~~~l~~~~~~~~~r~~a~~~l~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~l~~~l~~~l~~~~~~-r~~~~~~ 112 (442) T 1F59_B 35 TFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDP-DIKAQYQQRWLAIDANARREVKNYVLHTLGTETYR-PSSASQC 112 (442) T ss_dssp HHHHHHHHHTTCTTSCHHHHHHHHHHHHTTTCCSSH-HHHHHHHHHHHTSCHHHHHHHHHHHHHHTTCCSSS-SCHHHHH T ss_pred HHHHHHHHHHhCCCCCHHHHHHHHHHHHHHhhcCCH-HHHHHHHHHHhhCCHHHHHHHHHHHHHHHCCCCCc-hhHHHHH Confidence 4556667776521 3566777788888887643110 00 00000001234555566666544333 7778888 Q NP_000290.2 619 LSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNS--EDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA 696 (747) Q Consensus 619 LsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d--~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~ 696 (747) ++.++...... .....+++.+...+.+ .+ +.++..++.+|..+...............+++.+..++.+. T Consensus 113 l~~l~~~~~~~-~~~~~~~~~l~~~l~~------~~~~~~~~~~~l~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~- 184 (442) T 1F59_B 113 VAGIACAEIPV-NQWPELIPQLVANVTN------PNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKE- 184 (442) T ss_dssp HHHHHHHHGGG-TCCTTHHHHHHHHHHC------TTCCHHHHHHHHHHHHHHHHHSCGGGGGGGHHHHHHHHHHTTSTT- T ss_pred HHHHHHhcCCc-chhchHHHHHHHHhhC------CCCcHHHHHHHHHHHHHHHhhCCHHHhHHHHHHHHHHHHHHHhcC- Confidence 88777541110 0112356666666665 23 67888888998888764221111111124566777777655 Q NP_000290.2 697 S--PKAAEAARLLLSDMWSS 714 (747) Q Consensus 697 d--~eVr~aAL~aLsnL~~~ 714 (747) + ..++..++.++..++.. T Consensus 185 ~~~~~vr~~a~~~l~~l~~~ 204 (442) T 1F59_B 185 EPSNNVKLAATNALLNSLEF 204 (442) T ss_dssp CCCHHHHHHHHHHHHHHSTT T ss_pred CCCHHHHHHHHHHHHHHHHH Confidence 4 78889999988888654 No 430 >2NYL_A Protein phosphatase 2, regulatory subunit; HEAT repeat, HYDROLASE-HYDROLASE INHIBITOR COMPLEX; HET: DAL, MSE, ACB, 1ZN, DAM, FGA; 3.8A {Homo sapiens} SCOP: a.118.1.2 Probab=77.33 E-value=0.16 Score=49.36 Aligned_cols=70 Identities=17% Similarity=0.113 Sum_probs=41.5 Template_Neff=13.500 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) ..++.+...+. +.++.++..++.++..+...... . . .....++.+...+.+.++.++..++.++..+... T Consensus 318 ~~~~~l~~~l~-~~~~~vr~~~~~~l~~l~~~~~~------~-~-~~~~~~~~l~~~l~~~~~~v~~~a~~~l~~l~~~ 387 (582) T 2NYL_A 318 QILPCIKELVS-DANQHVKSALASVIMGLSPILGK------D-N-TIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEV 387 (582) T ss_dssp CCHHHHHHHHT-CSCHHHHHHHHHHGGGGHHHHHH------H-H-CCCCCHHHHHHHHHCSSHHHHHHHHTTHHHHTTT T ss_pred HHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHHhCC------c-c-chhhHHHHHHHHhcCCCHHHHHHHHHhHHHHHHh Confidence 34556666666 35666777777777776653211 1 1 1134556666666666667777777777766643 No 431 >5FVM_B SERINE/THREONINE-PROTEIN KINASE TOR2, TARGET OF; TRANSFERASE, CRYO-EM, TOR, LST8, MTOR; 6.7A {KLUYVEROMYCES MARXIANUS} Probab=77.24 E-value=0.18 Score=61.64 Aligned_cols=71 Identities=11% Similarity=0.111 Sum_probs=39.6 Template_Neff=11.500 Q NP_000290.2 548 AIRTYLNLMGKSKKD-ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~-eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) ++..+..++.. ... .++..++.++..++..... ....+ -..+++.+...+.+.++.++..++.+|..++.. T Consensus 925 ~~~~l~~~l~~-~~~~~~~~~~~~~l~~i~~~~~~-----~~~~~-l~~l~~~l~~~l~~~~~~vr~~a~~~L~~l~~~ 996 (2471) T 5FVM_B 925 VIGVLMKILKD-PSLSIHHSTVIQAIMHIFQTMGL-----RCVIF-LKQIIPGFILVMHTCPPSLLELYFQQLSVLISI 996 (2471) T ss_dssp HHHHHHHHHHC----CCHHHHHHHHHHHHHHHC-----------C-HHHHHHHHHHHHC--CHHHHHHHHHHHHHHTTS T ss_pred HHHHHHHHHcC-ccchHHHHHHHHHHHHHHHHccc-----hhHHH-HhHHHHHHHHHHhhCCHHHHHHHHHHHHHHHHH Confidence 34556666652 322 2666777788777653221 01111 134566677777766778888888888888764 No 432 >3LTJ_A AlphaRep-4; protein engineering, HEAT-like repeat, PROTEIN; 1.8A {synthetic} Probab=77.21 E-value=0.18 Score=42.73 Aligned_cols=121 Identities=12% Similarity=0.121 Sum_probs=68.3 Template_Neff=12.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..+... ..++.+...+.+.++.++..++.++..+... T Consensus 77 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~----------------~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~-- 137 (201) T 3LTJ_A 77 AVEPLIKALK-DEDGWVRQSAAVALGQIGDE----------------RAVEPLIKALKDEDWFVRIAAAFALGEIGDE-- 137 (201) T ss_dssp GHHHHHHHTT-CSSHHHHHHHHHHHHHHCCG----------------GGHHHHHHHTTCSSHHHHHHHHHHHHHHTCG-- T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHhCCH----------------HHHHHHHHHHhCCCHHHHHHHHHHHHHHCCH-- Confidence 3445555565 35566666666666655421 1233444555566667777777776665431 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ..++.+...+.+ .++.++..++.++..+... .....+..++.+. ++.++..++.+ T Consensus 138 -------~~~~~l~~~l~~------~~~~v~~~a~~~l~~~~~~-----------~~~~~l~~~~~~~-~~~vr~~a~~~ 192 (201) T 3LTJ_A 138 -------RAVEPLIKALKD------EDGWVRQSAADALGEIGGE-----------RVRAAMEKLAETG-TGFARKVAVNY 192 (201) T ss_dssp -------GGHHHHHHHTTC------SSHHHHHHHHHHHHHHCSH-----------HHHHHHHHHHHHC-CHHHHHHHHHH T ss_pred -------HHHHHHHHHHhC------CChHHHHHHHHHHHHhCcH-----------HHHHHHHHHHHcC-CHHHHHHHHHH Confidence 133444455544 2456677777777665431 2334455555555 67778888877 Q NP_000290.2 708 LSDMW 712 (747) Q Consensus 708 LsnL~ 712 (747) |.++. T Consensus 193 l~~~~ 197 (201) T 3LTJ_A 193 LETHK 197 (201) T ss_dssp HHHCC T ss_pred HHhhh Confidence 77654 No 433 >5JO8_A CEP104; centriolar protein, TOG domain, CEP104; 1.4A {Gallus gallus} Probab=77.19 E-value=0.18 Score=46.55 Aligned_cols=155 Identities=14% Similarity=0.100 Sum_probs=90.5 Template_Neff=11.100 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLM---SSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~---s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) .++.+...+. +.++.++..++.++..++...... ... .... .-..+++.|+..+.+.+..++..+..+|..++. T Consensus 87 l~~~l~~~l~-d~~~~v~~~a~~~l~~l~~~~~~~~~~~~~-~~~~-~~~~~l~~ll~~l~d~~~~vr~~a~~~l~~l~~ 163 (279) T 5JO8_A 87 AIFLVRRAIK-DIVSSVFQASLKLLKMIITQYVPKHKLGKL-ETSH-CVEKTLPGLLSRTGDSSSRLRIVAAKFIQEMAL 163 (279) T ss_dssp HHHHHHHHTT-CSSHHHHHHHHHHHHHCCCCCHHHHTCCHH-HHHH-HHHHHHHHHHHHTTCSSHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHcC-CCHHHHHHHHHHHHHHHHHHhcccccCChH-HHHH-HHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHc Confidence 3445555666 466778888888888877542000 000 0111 113466777777777778888999999888875 Q NP_000290.2 625 HPLLHRVMGNQVFP-EVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 625 ~~e~~~ll~~giI~-~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) ..... ...++. .+...+... .++.++..++.+|..++..............+++.+...+.+. ++.++.. T Consensus 164 ~~~~~---~~~~~~~~l~~~l~~~-----~~~~~r~~~l~~l~~l~~~~~~~~~~~~~~~i~~~l~~~l~d~-~~~VR~~ 234 (279) T 5JO8_A 164 WSEVK---PLQIVPVHLVQLLKPN-----SPTHLAMSRVELVECLLKEMGTENSGFTISNVMKFATGALEHR-VYEVRDV 234 (279) T ss_dssp STTTG---GGCCHHHHHTSCCCTT-----SCHHHHHHHHHHHHHHHHHHCSSSSSCCHHHHHHHHHHHTTCS-CHHHHHH T ss_pred CCCCC---hhHhHHHHHhhcCCCC-----CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHhcCC-CHHHHHH Confidence 42110 011222 222333331 1566777888888887764322211111224567777777766 8899999 Q NP_000290.2 704 ARLLLSDMWSS 714 (747) Q Consensus 704 AL~aLsnL~~~ 714 (747) +..++..+... T Consensus 235 a~~~l~~l~~~ 245 (279) T 5JO8_A 235 ALRIIFGMYRK 245 (279) T ss_dssp HHHHHHHHHHH T ss_pred HHHHHHHHHHH Confidence 99988887643 No 434 >4P6Z_G BST2/tetherin, HIV-1 Vpu, Clathrin adaptor; BST2, tetherin, Vpu, HIV, clathrin; 3.0A {Mus musculus} Probab=77.19 E-value=0.18 Score=51.67 Aligned_cols=101 Identities=12% Similarity=0.040 Sum_probs=52.0 Template_Neff=12.000 Q NP_000290.2 246 TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLET 325 (747) Q Consensus 246 iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~l 325 (747) +++.+...+.+.+..++..++..+..+.... ....+++.+...+.+.++.++..++.++..+....+... T Consensus 117 ~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~-------~~~~~~~~l~~~l~~~~~~vr~~a~~~L~~l~~~~~~~~--- 186 (627) T 4P6Z_G 117 MTNCIKNDLNHSTQFVQGLALCTLGCMGSSE-------MCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELM--- 186 (627) T ss_dssp HHHHHHHHHTCSSHHHHHHHHHHHHHHCCHH-------HHHHHHHHHHHHHTCSCHHHHHHHHHHHHHHHHHCSGGG--- T ss_pred HHHHHHHHhhCCCHHHHHHHHHHHHhcCCHH-------HHHHHHHHHHHHhhCCCHHHHHHHHHHHHHHHHHCHHHH--- Confidence 3444444444555556666666665554211 011334455555555566666666666666654322111 Q NP_000290.2 326 RRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 326 l~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas 359 (747) ..+++.+...+. +.++.++..++.++..+.. T Consensus 187 --~~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~ 217 (627) T 4P6Z_G 187 --EMFLPATKNLLN-EKNHGVLHTSVVLLTEMCE 217 (627) T ss_dssp --GGGHHHHTTCTT-CCCHHHHHHHHHHHHHHHH T ss_pred --HHHHHHHHHHHh-CCCHHHHHHHHHHHHHHHH Confidence 234445555554 4455666666666666654 No 435 >1GCJ_B IMPORTIN-BETA; HEAT REPEAT MOTIF, NUCLEAR PORE-TARGETING; HET: MSE; 2.6A {Mus musculus} SCOP: a.118.1.1 Probab=77.16 E-value=0.17 Score=48.43 Aligned_cols=154 Identities=10% Similarity=0.066 Sum_probs=84.6 Template_Neff=12.800 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLM--------S----SGMSQ----LIGLKEKGLPQIARLLQSG----- 607 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~--------s----~~~~~----~llie~giI~~Ll~LL~s~----- 607 (747) ++.+..++. +.++.++..++.++..++...... . ..... .. .-..+++.+...+... T Consensus 267 ~~~l~~~l~-~~~~~v~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~l~~~l~~~l~~~~~~~~ 344 (460) T 1GCJ_B 267 FAITIEAMK-SDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKG-ALQYLVPILTQTLTKQDENDD 344 (460) T ss_dssp HHHHHHHHT-CSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSCCSSCCCCHHHH-HHHHHHHHHHHHGGGCCSSSC T ss_pred HHHHHHHhh-CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCcchhhhhhHhH-HHHHHHHHHHHHHhcCCCCCC Confidence 555666666 356777778888888776531000 0 00000 00 0122344444444322 Q NP_000290.2 608 --NSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQL-AKQYFSSSM 684 (747) Q Consensus 608 --d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~-~~~Lve~gi 684 (747) +..++..+..++..++..... ..+ ..+++.+...+.+ .++.++..++.+|..+....... ....+ ..+ T Consensus 345 ~~~~~~~~~a~~~l~~l~~~~~~-~~~-~~~~~~l~~~l~~------~~~~~r~~a~~~l~~l~~~~~~~~~~~~~-~~~ 415 (460) T 1GCJ_B 345 DDDWNPCKAAGVCLMLLSTCCED-DIV-PHVLPFIKEHIKN------PDWRYRDAAVMAFGSILEGPEPNQLKPLV-IQA 415 (460) T ss_dssp TTSCCHHHHHHHHHHHHHHHHGG-GHH-HHHHHHHHHHTTC------SSHHHHHHHHHHHHHTSSSSCHHHHHHHH-HHH T ss_pred CCCCcHHHHHHHHHHHHHhhCcc-ccH-HHHHHHHHHHhcC------CChHHHHHHHHHHHHHHcCCChhhHHHHH-HHH Confidence 345666677777776654110 111 1234444444444 36778889999999988653321 11111 245 Q NP_000290.2 685 LNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 685 L~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++.+...+.+. ++.++..++++|..++.. T Consensus 416 ~~~l~~~l~~~-~~~vr~~a~~~l~~l~~~ 444 (460) T 1GCJ_B 416 MPTLIELMKDP-SVVVRDTTAWTVGRICEL 444 (460) T ss_dssp HHHHHHHTTCS-CHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHhCCC-CHHHHHHHHHHHHHHHHh Confidence 66667777666 788999999999988754 No 436 >6GWC_C Tubulin alpha chain, Tubulin beta; microtubule, ARTIFICIAL PROTEIN, ALPHAREP, cytoskeleton; HET: GTP, MES, PGE; 2.6A {Ovis aries} Probab=76.89 E-value=0.18 Score=43.85 Aligned_cols=121 Identities=12% Similarity=0.169 Sum_probs=73.3 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+..++. +.++.++..++.+|..+... ..++.+..++.+.++.++..++.++..+... T Consensus 108 ~~~~l~~~l~-~~~~~~r~~a~~~l~~~~~~----------------~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~-- 168 (232) T 6GWC_C 108 AVEPLIKALK-DEDTTVRRIAATALGKIGDE----------------RAVEPLIKALKDEDAAVRLTAARALGEIGDE-- 168 (232) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHhccc----------------chHHHHHHHhcCCCHHHHHHHHHHHHHhCCh-- Confidence 3455666665 35667777777777665431 1233455566666777888888777766431 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ..++.+...+.+ .++.++..++.+|..+... ..+..+..++.+. ++.++..++.+ T Consensus 169 -------~~~~~l~~~l~~------~~~~v~~~a~~~l~~~~~~-----------~~~~~l~~~~~~~-~~~v~~~a~~~ 223 (232) T 6GWC_C 169 -------RAVEPLIKALKD------EDAYVRRAAAQALGKIGGE-----------RVRAAMEKLAETG-TGFARKVAVNY 223 (232) T ss_pred -------hHHHHHHHHhcC------CCHHHHHHHHHHHHHhCcC-----------chHHHHHHHHhCC-CHHHHHHHHHH Confidence 234445555554 2567777788887776542 2344455555554 66777778777 Q NP_000290.2 708 LSDMW 712 (747) Q Consensus 708 LsnL~ 712 (747) |..+. T Consensus 224 l~~~~ 228 (232) T 6GWC_C 224 LETHK 228 (232) T ss_pred HHHHH Confidence 77654 No 437 >3QML_D 78 kDa glucose-regulated protein homolog; Armadillo like repeats, CHAPERONE-PROTEIN TRANSPORT; HET: PO4; 2.31A {Saccharomyces cerevisiae} Probab=76.82 E-value=0.22 Score=49.40 Aligned_cols=104 Identities=8% Similarity=0.064 Sum_probs=73.8 Template_Neff=7.900 Q NP_000290.2 609 SDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSS--ML 685 (747) Q Consensus 609 ~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~g--iL 685 (747) ...+..++.-|..++..-++ ..+...+ +..|+.++... .....++..|+++|+..+.+++.....+.+.+ ++ T Consensus 42 ~~~~~~aLd~L~dl~hdid~a~~~~~~g-~~~L~~~l~~~----~~~~~ir~~Aa~iigsa~qNNP~aq~~~~~~~~~~l 116 (315) T 3QML_D 42 IARLEDSFDRIMEFAHDYKHGYKIITHE-FALLANLSLNE----NLPLTLRELSTRVITSCLRNNPPVVEFINESFPNFK 116 (315) T ss_dssp HHHHHHHHHHHHHHHTSHHHHHHHHHHH-HHHHHHHHHCT----TSCHHHHHHHHHHHHHHHTTCTTHHHHHHHHCTTHH T ss_pred HHHHHHHHHHHHHHHccHHHHHHHHHch-HHHHHHHHhCC----CCCHHHHHHHHHHHHHHHhhCHHHHHHHHHHCccHH Confidence 34455566666666655333 3455566 77777776541 02578999999999999999988888888766 67 Q NP_000290.2 686 NNII---NLCRS---SASPKAAEAARLLLSDMWSSKEL 717 (747) Q Consensus 686 ~~Ll---~LL~s---~~d~eVr~aAL~aLsnL~~~~~~ 717 (747) +.|+ ..+.. ..++.++..++.+|+.++.+.+. T Consensus 117 ~~Ll~~~~~L~~~~~~~~~~v~~k~L~aLS~Lir~~~~ 154 (315) T 3QML_D 117 SKIMAALSNLNDSNHRSSNILIKRYLSILNELPVTSED 154 (315) T ss_dssp HHHHHHHHHHHCC---CTHHHHHHHHHHHHHSCCCGGG T ss_pred HHHHHHHHhhccCCCcCCHHHHHHHHHHHHhhcCCCcc Confidence 7777 44443 22678889999999999988765 No 438 >4G3A_B CLIP-associating protein; TOG domain, HEAT repeat, MAP; HET: GOL; 1.994A {Drosophila melanogaster} Probab=76.80 E-value=0.18 Score=43.50 Aligned_cols=113 Identities=13% Similarity=0.037 Sum_probs=64.2 Template_Neff=12.600 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.+...+.+.++.++..++..+..++..............+++.+...+.+.++.++..++.++..++........ T Consensus 6 ~~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~d~~~~v~~~a~~~l~~l~~~~~~~~~ 85 (237) T 4G3A_B 6 PSDLDGFIQQMPKADMRVKVQLAEDLVTFLSDDTNSIVCTDMGFLIDGLMPWLTGSHFKIAQKSLEAFSELIKRLGSDFN 85 (237) T ss_dssp CSSHHHHHHHSTTCCHHHHHHHHHHHHHHHHCTTSCCCCSCHHHHHHHHGGGGSSSCHHHHHHHHHHHHHHHHHHGGGGG T ss_pred cchHHHHHHhcCcCCHHHHHHHHHHHHHHhhCCCCCcccccHHHHHHHHHHHhcCCcHHHHHHHHHHHHHHHHHhhhhHH Confidence 34455566666677778888888888887764321111111123556666667667778888888888887754332111 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) .. ...+++.+...+. +.+..++..++.++..+. T Consensus 86 ~~-~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~ 118 (237) T 4G3A_B 86 AY-TATVLPHVIDRLG-DSRDTVREKAQLLLRDLM 118 (237) T ss_dssp GT-HHHHHHHHHHHHT-CSCHHHHHHHHHHHHHHH T ss_pred HH-HHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHH Confidence 11 1234455555554 334445555555555544 No 439 >6IDX_A Engulfment and cell motility protein; Adhesion GPCRs, CELL ADHESION; 1.699A {Homo sapiens} Probab=76.77 E-value=0.22 Score=52.79 Aligned_cols=157 Identities=13% Similarity=0.168 Sum_probs=98.0 Template_Neff=8.400 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG------NSDVVRSGASLLSNMSRHP-LL-HRVMGN 634 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~------d~eVr~~AL~aLsnLa~~~-e~-~~ll~~ 634 (747) ..+..++.-|..++.. .. ....|++.+++..|+.++... +......++.+|..+.... .. ..+. . T Consensus 102 ~~~~~~L~~L~~~~~d-~~-----f~~EFi~~~Gl~~L~~~l~~~~~~~~~~~~~l~~~L~al~~lM~~~~~g~~~l~-~ 174 (524) T 6IDX_A 102 ETRLDAMKELAKLSAD-VT-----FATEFINMDGIIVLTRLVESGTKLLSHYSEMLAFTLTAFLELMDHGIVSWDMVS-I 174 (524) T ss_pred HHHHHHHHHHHHHhcC-hh-----HHHHHHHcChHHHHHHHHHhCCCCCCCChhHHHHHHHHHHHHHhcCcccHhhch-H Confidence 3444566666666653 22 345557788999999988863 4466777888888888764 32 2222 3 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ..+..|..++... ..+..+...++.+|..++...+.....+.....+..|+..|... +..++..++.++..|... T Consensus 175 ~~i~~l~~~l~~~----~~~~~v~~~aL~iL~~l~~~~~~~~~~v~~~~~f~~Lv~~L~~~-d~~~q~~~L~LINaLl~~ 249 (524) T 6IDX_A 175 TFIKQIAGYVSQP----MVDVSILQRSLAILESMVLNSQSLYQKIAEEITVGQLISHLQVS-NQEIQTYAIALINALFLK 249 (524) T ss_pred HHHHHHHHHhCCC----CCChhHHHHHHHHHHHHHhcCHHHHHHHHcCCCHHHHHHHHccC-CHHHHHHHHHHHHHHHhc Confidence 4667777777542 00237888899999888775433333222222377788888765 677778887777777654 Q NP_000290.2 715 K------ELQGVLRQQGFDRNML 731 (747) Q Consensus 715 ~------~~~~~~~~~~~~~~~~ 731 (747) . ++..-|...|+..-.. T Consensus 250 ~~~~~~~~i~~~L~~~gi~~~i~ 272 (524) T 6IDX_A 250 APEDKRQDMANAFAQKHLRSIIL 272 (524) T ss_pred CCcccHHHHHHHHHHcCHHHHHH Confidence 4 3444555666655433 No 440 >6IE1_A Engulfment and cell motility protein; Adhesion GPCR, BAI1-ELMO2 Complex, cell; HET: GOL; 2.48A {Homo sapiens} Probab=76.77 E-value=0.22 Score=52.79 Aligned_cols=157 Identities=13% Similarity=0.168 Sum_probs=98.0 Template_Neff=8.400 Q NP_000290.2 563 ATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSG------NSDVVRSGASLLSNMSRHP-LL-HRVMGN 634 (747) Q Consensus 563 eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~------d~eVr~~AL~aLsnLa~~~-e~-~~ll~~ 634 (747) ..+..++.-|..++.. .. ....|++.+++..|+.++... +......++.+|..+.... .. ..+. . T Consensus 102 ~~~~~~L~~L~~~~~d-~~-----f~~EFi~~~Gl~~L~~~l~~~~~~~~~~~~~l~~~L~al~~lM~~~~~g~~~l~-~ 174 (524) T 6IE1_A 102 ETRLDAMKELAKLSAD-VT-----FATEFINMDGIIVLTRLVESGTKLLSHYSEMLAFTLTAFLELMDHGIVSWDMVS-I 174 (524) T ss_pred HHHHHHHHHHHHHhcC-hh-----HHHHHHHcChHHHHHHHHHhCCCCCCCChhHHHHHHHHHHHHHhcCcccHhhch-H Confidence 3444566666666653 22 345557788999999988863 4466777888888888764 32 2222 3 Q NP_000290.2 635 QVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 635 giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ..+..|..++... ..+..+...++.+|..++...+.....+.....+..|+..|... +..++..++.++..|... T Consensus 175 ~~i~~l~~~l~~~----~~~~~v~~~aL~iL~~l~~~~~~~~~~v~~~~~f~~Lv~~L~~~-d~~~q~~~L~LINaLl~~ 249 (524) T 6IE1_A 175 TFIKQIAGYVSQP----MVDVSILQRSLAILESMVLNSQSLYQKIAEEITVGQLISHLQVS-NQEIQTYAIALINALFLK 249 (524) T ss_pred HHHHHHHHHhCCC----CCChhHHHHHHHHHHHHHhcCHHHHHHHHcCCCHHHHHHHHccC-CHHHHHHHHHHHHHHHhc Confidence 4667777777542 00237888899999888775433333222222377788888765 677778887777777654 Q NP_000290.2 715 K------ELQGVLRQQGFDRNML 731 (747) Q Consensus 715 ~------~~~~~~~~~~~~~~~~ 731 (747) . ++..-|...|+..-.. T Consensus 250 ~~~~~~~~i~~~L~~~gi~~~i~ 272 (524) T 6IE1_A 250 APEDKRQDMANAFAQKHLRSIIL 272 (524) T ss_pred CCcccHHHHHHHHHHcCHHHHHH Confidence 4 3444555666655433 No 441 >5H2V_A Importin subunit beta-3, Ubiquitin-like-specific protease; nuclear import, PROTEIN TRANSPORT-HYDROLASE complex; 2.8A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=76.57 E-value=0.18 Score=54.22 Aligned_cols=157 Identities=9% Similarity=0.079 Sum_probs=92.1 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) +++.+...+. +.++.++..++.++..++..... .... ....+++.|...+.+.++.++..++.+|+.++.. + T Consensus 849 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 921 (1078) T 5H2V_A 849 IWPMINTFLL-DNEPILVIFALVVIGDLIQYGGE-----QTAS-MKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAP 921 (1078) T ss_dssp GHHHHHHHHH-SSSHHHHHHHHHHHHHHHHHHTT-----TTTT-THHHHHHHHHHHHTCSCHHHHHHHHHHHHHHHHHCT T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHhcch-----hhHH-HHHhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHCc Confidence 3445555555 35667777888888887754221 1111 1245677778888888889999999999999876 2 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. ...+ ..+++.+...+.........+..++..++.+|..+....+.... ....+++.++..+....+..++..++ T Consensus 922 ~~~~~~~-~~~l~~l~~~l~~~~~~~~~~~~~~~~a~~~l~~l~~~~~~~~~--~~~~~~~~l~~~l~~~~~~~~~~~~~ 998 (1078) T 5H2V_A 922 STYADVC-IPTLDTLVQIVDFPGSKLEENRSSTENASAAIAKILYAYNSNIP--NVDTYTANWFKTLPTITDKEAASFNY 998 (1078) T ss_dssp TTTHHHH-TTTHHHHHHHTC--CCSSTTTHHHHHHHHHHHHHHHHHC---------CHHHHHHHTTCCCCSCHHHHHHHH T ss_pred cchHHhH-HHHHHHHHHHHhCCCCccccccchHHHHHHHHHHHHHHcccCCC--ChhHHHHHHHHhCCccCCHHHHHHHH Confidence 21 1111 34666677766521000003567888899999888764322111 11234556666664222567777888 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..+... T Consensus 999 ~~l~~l~~~ 1007 (1078) T 5H2V_A 999 QFLSQLIEN 1007 (1078) T ss_dssp HHHHHHHC- T ss_pred HHHHHHHHc Confidence 888777654 No 442 >1TE4_A conserved protein MTH187; MTH187, Methanobacterium thermoautotrophicum, structural proteomics; NMR {Methanothermobacter thermautotrophicus} SCOP: a.118.1.16 Probab=76.51 E-value=0.19 Score=39.52 Aligned_cols=118 Identities=13% Similarity=0.147 Sum_probs=65.1 Template_Neff=12.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) ..+.+...+. +.++.++..++..|..+.. ..++.+...+.+.++.++..++.++..+... T Consensus 13 ~~~~~~~~l~-~~~~~~r~~a~~~l~~~~~-----------------~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~~-- 72 (131) T 1TE4_A 13 GLVPRGSHMA-DENKWVRRDVSTALSRMGD-----------------EAFEPLLESLSNEDWRIRGAAAWIIGNFQDE-- 72 (131) T ss_dssp --------CC-SSCCCSSSSCCSSTTSCSS-----------------TTHHHHHHGGGCSCHHHHHHHHHHHGGGCSH-- T ss_pred CccccHHHhc-CCCHHHHHHHHHHHHHhcH-----------------HHHHHHHHHhcCCCHHHHHHHHHHHHcCCCh-- Confidence 3455666666 4666777777766654421 1234455556666777888888888776532 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ..++.|...+.+ .++.++..++.+|..+... ..++.+...+.+. +..++..++.+ T Consensus 73 -------~~~~~l~~~l~~------~~~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~vr~~a~~~ 127 (131) T 1TE4_A 73 -------RAVEPLIKLLED------DSGFVRSGAARSLEQIGGE-----------RVRAAMEKLAETG-TGFARKVAVNY 127 (131) T ss_dssp -------HHHHHHHHHHHH------CCTHHHHHHHHHHHHHCSH-----------HHHHHHHHHTTSC-CTHHHHHHHHH T ss_pred -------hhHHHHHHHhcC------CCHHHHHHHHHHHHHhCCH-----------HHHHHHHHHHcCC-CHHHHHHHHHH Confidence 133444455544 2567777788888776531 1344455555544 56677766666 Q NP_000290.2 708 LSD 710 (747) Q Consensus 708 Lsn 710 (747) +.. T Consensus 128 l~~ 130 (131) T 1TE4_A 128 LET 130 (131) T ss_dssp GGG T ss_pred Hhc Confidence 543 No 443 >6S47_Bi 60S ribosomal protein L2-A, 60S; New1, ABCF, Ribosomal Protein, Recycling; HET: ATP; 3.28A {Saccharomyces cerevisiae} Probab=76.45 E-value=0.2 Score=54.82 Aligned_cols=155 Identities=15% Similarity=0.167 Sum_probs=91.4 Template_Neff=11.700 Q NP_000290.2 548 AIRTYLNLMGKSKK-DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH- 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d-~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~- 625 (747) +++.|..++.. .+ +.++..++.+|..++..... .........+++.|+.++.+.++.++..|+.+|..++.. T Consensus 127 ~~~~l~~~l~~-~~~~~vr~~a~~~l~~i~~~~~~-----~~~~~~~~~~~~~l~~~l~d~~~~vr~~a~~~L~~l~~~~ 200 (972) T 6S47_Bi 127 VLPTILDYLSS-GAKWQAKMAALSVVDRIREDSAN-----DLLELTFKDAVPVLTDVATDFKPELAKQGYKTLLDYVSIL 200 (972) T ss_pred hHHHHHHHcCC-CCCHHHHHHHHHHHHHHHhhCCH-----HHHHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHh Confidence 46667777763 44 67888889998888543221 111112345777788888888888899999988888753 Q NP_000290.2 626 PL-L-H----RV---MG--------------------------NQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMA 670 (747) Q Consensus 626 ~e-~-~----~l---l~--------------------------~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~ 670 (747) .. . . .+ +. ..+++.+...+.+. ..+..++..++++|..++. T Consensus 201 ~~~~~~~~~~~l~~~l~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~----~~~~~vr~~a~~~l~~l~~ 276 (972) T 6S47_Bi 201 DNLDLSPRYKLIVDTLQDPSKVPESVKSLSSVTFVAEVTEPSLSLLVPILNRSLNLS----SSSQEQLRQTVIVVENLTR 276 (972) T ss_pred CcHHHHHHHHHHHHHcCChHHHHHHHHHHHHhhCCCCCCcccHHHHHHHHHHHHhCC----CCCHHHHHHHHHHHHHHHH Confidence 10 0 0 00 00 00223333333220 0245677788888888875 Q NP_000290.2 671 --SQPQLAKQYFSSSMLNNIINLC-RSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 671 --~s~e~~~~Lve~giL~~Ll~LL-~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ........+ ...+++.|+..+ .+. +..++..|+.+|..++.. T Consensus 277 ~~~~~~~~~~~-~~~i~~~L~~~l~~d~-~~~vr~~a~~~l~~l~~~ 321 (972) T 6S47_Bi 277 LVNNRNEIESF-IPLLLPGIQKVVDTAS-LPEVRELAEKALNVLKED 321 (972) T ss_pred hcCChhHcHhh-HHHHHHHHHHHHhcCC-CHHHHHHHHHHHHHHhhh Confidence 211111111 124566777777 555 778899999999998876 No 444 >1OYZ_A X-RAY STRUCTURE OF YB61_HAEIN NORTHEAST; STRUCTURAL GENOMICS, PSI, Protein Structure; 2.1A {Escherichia coli} SCOP: a.118.1.16 Probab=76.37 E-value=0.19 Score=44.51 Aligned_cols=96 Identities=7% Similarity=0.086 Sum_probs=47.9 Template_Neff=12.700 Q NP_000290.2 596 GLPQIAR-LLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ 674 (747) Q Consensus 596 iI~~Ll~-LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e 674 (747) .++.+.. ++.+.++.++..++.+|..+...... .....++.+...+.+ .++.++..++.+|..+.. T Consensus 91 ~~~~l~~~~l~~~~~~vr~~a~~~l~~~~~~~~~---~~~~~~~~l~~~l~~------~~~~v~~~a~~~l~~~~~---- 157 (280) T 1OYZ_A 91 VFNILNNMALNDKSACVRATAIESTAQRCKKNPI---YSPKIVEQSQITAFD------KSTNVRRATAFAISVIND---- 157 (280) T ss_dssp HHHHHHHHHHHCSCHHHHHHHHHHHHHHHHHCGG---GHHHHHHHHHHHTTC------SCHHHHHHHHHHHHTC------ T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHHhcCcc---cChhHHHHHHHHhcC------CCHHHHHHHHHHHHhhcc---- Confidence 3444444 44444555555555555554432100 112244455555544 245566666666655442 Q NP_000290.2 675 LAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMW 712 (747) Q Consensus 675 ~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~ 712 (747) ...++.+..++.+. ++.++..++.++..+. T Consensus 158 -------~~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~ 187 (280) T 1OYZ_A 158 -------KATIPLLINLLKDP-NGDVRNWAAFAININK 187 (280) T ss_dssp --------CCHHHHHHHHTCS-SHHHHHHHHHHHHHHT T ss_pred -------hhhHHHHHHHHcCC-CHHHHHHHHHHHHhhc Confidence 12345555666655 6677777777777543 No 445 >5NR4_A CLIP-associating protein 2; Microtubules, TOG domain, Tubulin, Structural; 1.198A {Homo sapiens} Probab=76.18 E-value=0.19 Score=42.69 Aligned_cols=111 Identities=10% Similarity=0.045 Sum_probs=61.9 Template_Neff=12.900 Q NP_000290.2 595 KGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HR---V--MGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNL 668 (747) Q Consensus 595 giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~---l--l~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnL 668 (747) ..++.+...+.+.+..++..++..|..+...... .. . ....+++.+...+.+ .++.++..++.++..+ T Consensus 6 ~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l 79 (230) T 5NR4_A 6 RSMEYFCAQVQQKDVGGRLQVGQELLLYLGAPGAISDLEEDLGRLGKTVDALTGWVGS------SNYRVSLMGLEILSAF 79 (230) T ss_dssp CCHHHHHHHTTCSCGGGHHHHHHHHHHHHHC-----CTTSCHHHHHHHHHHHHHHHHC------SSHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHhCCChhHHHHHHHHHHHHhcCCcccCchHHHHHHHHHHHHHHHHHHcC------CCHHHHHHHHHHHHHH Confidence 3455566666667778888888888888765211 10 0 012345555666654 3677888888888888 Q NP_000290.2 669 MASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 669 a~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) +...+....... ..+++.++..+.+. +..++..++.++..++. T Consensus 80 ~~~~~~~~~~~~-~~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~~ 122 (230) T 5NR4_A 80 VDRLSTRFKSYV-AMVIVALIDRMGDA-KDKVRDEAQTLILKLMD 122 (230) T ss_dssp HHHHGGGGGGGH-HHHHHHHHHHTTCS-SHHHHHHHHHHHHHHHH T ss_pred HHHhhHHHHHHH-HHHHHHHHHHhccC-CHHHHHHHHHHHHHHHH Confidence 764322111111 23445555555544 45566666666665553 No 446 >5A1V_E ADP-RIBOSYLATION FACTOR 1, COATOMER SUBUNIT; TRANSPORT PROTEIN, COPI, COATOMER, COATED; 21.0A {SACCHAROMYCES CEREVISIAE} Probab=75.90 E-value=0.22 Score=54.55 Aligned_cols=137 Identities=11% Similarity=0.073 Sum_probs=78.0 Template_Neff=10.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.|+.++. +.+..++..++.++..+....+. . ..+++.|...+.+.++.++..++.+|..+..... T Consensus 69 l~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~----------~-~~i~~~l~~~L~~~~~~vr~~al~~L~~~~~~~~ 136 (874) T 5A1V_E 69 AFFAMTKLFQ-SNDPTLRRMCYLTIKEMSCIAED----------V-IIVTSSLTKDMTGKEDNYRGPAVRALCQITDSTM 136 (874) T ss_dssp HHHHHHHGGG-SCCHHHHHHHHHHHHHHHTSCSC----------G-GGHHHHHHHHHHSSSHHHHHHHHHHHHHHCCHHH T ss_pred HHHHHHHHHc-CCCHHHHHHHHHHHHHhcccCch----------H-hHHHHHHHHhcCCCChhhHHHHHHHHhhcCCHHH Confidence 4555666666 36667777777777776653211 1 2345566666666677777777777776643210 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...+++.+...+.+ .++.++..++.++..+....+... ...++.+...+.+. ++.++..++.+ T Consensus 137 -----~~~l~~~l~~~l~d------~~~~Vr~~a~~~l~~l~~~~~~~~-----~~~~~~l~~~l~~~-~~~vr~~a~~~ 199 (874) T 5A1V_E 137 -----LQAVERYMKQAIVD------KVPSVSSSALVSSLHLLKCSFDVV-----KRWVNEAQEAASSD-NIMVQYHALGL 199 (874) T ss_dssp -----HHHHHHHHHHHHTC------SSHHHHHHHHHHHHHHHHHCHHHH-----HHTHHHHHHHHTCC-SHHHHHHHHHH T ss_pred -----HHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCHHHH-----HHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 01234444455544 256677777777777765322111 13445555555544 56667777766 Q NP_000290.2 708 LSDMWS 713 (747) Q Consensus 708 LsnL~~ 713 (747) |..+.. T Consensus 200 L~~l~~ 205 (874) T 5A1V_E 200 LYHVRK 205 (874) T ss_dssp HHHHHC T ss_pred HHHHHh Confidence 666654 No 447 >5NZR_G Coatomer subunit alpha, Coatomer subunit; COPI, coatomer, coated vesicles, Transport; 9.2A {Mus musculus} Probab=75.90 E-value=0.22 Score=54.55 Aligned_cols=137 Identities=11% Similarity=0.073 Sum_probs=78.0 Template_Neff=10.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.|+.++. +.+..++..++.++..+....+. . ..+++.|...+.+.++.++..++.+|..+..... T Consensus 69 l~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~----------~-~~i~~~l~~~L~~~~~~vr~~al~~L~~~~~~~~ 136 (874) T 5NZR_G 69 AFFAMTKLFQ-SNDPTLRRMCYLTIKEMSCIAED----------V-IIVTSSLTKDMTGKEDNYRGPAVRALCQITDSTM 136 (874) T ss_pred HHHHHHHHHc-CCCHHHHHHHHHHHHHhcccCch----------H-hHHHHHHHHhcCCCChhhHHHHHHHHhhcCCHHH Confidence 4555666666 36667777777777776653211 1 2345566666666677777777777776643210 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ...+++.+...+.+ .++.++..++.++..+....+... ...++.+...+.+. ++.++..++.+ T Consensus 137 -----~~~l~~~l~~~l~d------~~~~Vr~~a~~~l~~l~~~~~~~~-----~~~~~~l~~~l~~~-~~~vr~~a~~~ 199 (874) T 5NZR_G 137 -----LQAVERYMKQAIVD------KVPSVSSSALVSSLHLLKCSFDVV-----KRWVNEAQEAASSD-NIMVQYHALGL 199 (874) T ss_pred -----HHHHHHHHHHHhcC------CCHHHHHHHHHHHHHHHhcCHHHH-----HHHHHHHHHHhcCC-CHHHHHHHHHH Confidence 01234444455544 256677777777777765322111 13445555555544 56667777766 Q NP_000290.2 708 LSDMWS 713 (747) Q Consensus 708 LsnL~~ 713 (747) |..+.. T Consensus 200 L~~l~~ 205 (874) T 5NZR_G 200 LYHVRK 205 (874) T ss_pred HHHHHh Confidence 666654 No 448 >6HWP_A A3_bGFPD; alphaRep, artificial protein, chimera, bidomain; 2.547A {synthetic construct} Probab=75.54 E-value=0.21 Score=46.83 Aligned_cols=49 Identities=8% Similarity=0.078 Sum_probs=32.0 Template_Neff=12.900 Q NP_000290.2 654 SEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 654 d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++.++..++.++..+.. ...++.+..++.+. ++.++..++.++..+... T Consensus 129 ~~~vr~~~~~~l~~~~~-----------~~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~~~ 177 (409) T 6HWP_A 129 DWFVRIAAAFALGEIGD-----------ERAVEPLIKALKDE-DGWVRQSAADALGEIGGE 177 (409) T ss_dssp SHHHHHHHHHHHHHHTC-----------GGGHHHHHHGGGCS-SHHHHHHHHHHHHHHCCH T ss_pred CHHHHHHHHHHHHHhCC-----------hhhHHHHHHHhcCC-CHHHHHHHHHHHHHhcch Confidence 45666666666666543 12345566666655 678888888888887754 No 449 >3W3U_A Importin subunit beta-3; HEAT repeat, nuclear import, PROTEIN; 2.6A {Saccharomyces cerevisiae} Probab=75.50 E-value=0.21 Score=53.79 Aligned_cols=152 Identities=16% Similarity=0.150 Sum_probs=91.0 Template_Neff=13.000 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-PL 627 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~e 627 (747) ++.+...+. +.++.++..++.+|..++..... .... .-..+++.+...+.+.++.++..++.++..++.. .. T Consensus 358 ~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~ 430 (1078) T 3W3U_A 358 FQYLQQMIT-STEWRERFAAMMALSSAAAGCAD-----VLIG-EIPKILDMVIPLINDPHPRVQYGCCKVLGQISTAFSP 430 (1078) T ss_dssp HHHHHHHTT-CSSHHHHHHHHHHHHHHTTTTHH-----HHTT-SHHHHHHHHGGGGGCSSHHHHHHHHHHHHHHHHHTTT T ss_pred HHHHHHHhc-CCCHHHHHHHHHHHHHHHHccHH-----HHHh-hHHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHHccH Confidence 344445554 35677888888888888764321 0111 1135666677777777888999999999998865 11 Q NP_000290.2 628 L-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) . .......+++.+...+... .+..++..++.+|..++..... ..... -..++..+...+.+. ++.++..++ T Consensus 431 ~~~~~~~~~~~~~l~~~l~~~-----~~~~vr~~a~~~l~~l~~~~~~~~~~~~-~~~~~~~l~~~l~~~-~~~~~~~~~ 503 (1078) T 3W3U_A 431 FIQRTAHDRILPALISKLTSE-----CTSRVQTHAAAALVAFSEFASKDILEPY-LDSLLTNLLVLLQSN-KLYVQEQAL 503 (1078) T ss_dssp HHHHHHHHHHHHHHHHHSSTT-----SCHHHHHHHHHHHHHHHTTCCHHHHGGG-HHHHHHHHHHHHTCS-SHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHcCCC-----CCHHHHHHHHHHHHHHHHhCChhhhHHH-HHHHHHHHHHHhcCC-CHHHHHHHH Confidence 1 1111123555566655521 2567788888888888764221 11111 123556666666655 667777788 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .+|..++.. T Consensus 504 ~~l~~l~~~ 512 (1078) T 3W3U_A 504 TTIAFIAEA 512 (1078) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHH Confidence 887776643 No 450 >4QMI_B Cytoskeleton-associated protein 5; PROTEIN BINDING, TOG domain; 1.9A {Homo sapiens} Probab=75.47 E-value=0.21 Score=43.16 Aligned_cols=107 Identities=13% Similarity=0.065 Sum_probs=67.9 Template_Neff=12.600 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+........... ...+++.+...+.+.+..++..++.++..+..... T Consensus 59 ~~~~~l~~~l~d~~~~vr~~a~~~l~~l~~~~~~~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~----- 132 (240) T 4QMI_B 59 ELPTALKGRLNDSNKILVQQTLNILQQLAVAMGPNIKQH-VKNLGIPIITVLGDSKNNVRAAALATVNAWAEQTG----- 132 (240) T ss_dssp THHHHHHHHTTCSSHHHHHHHHHHHHHHHHHHGGGGGGG-CCCCCHHHHHHTTCSSHHHHHHHHHHHHHHHHHHC----- T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHhcHHHHHH-HHHHHHHHHHHhhcCCHHHHHHHHHHHHHHHHHhC----- Confidence 344555556666777888888888888876533221111 12355666666666667788888888877765422 Q NP_000290.2 325 TRRQNGI--REAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL--~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++ +.+...+. +.++.++..++.++..++.. T Consensus 133 --~~~~~~~~~l~~~l~-~~~~~~r~~~~~~l~~l~~~ 167 (240) T 4QMI_B 133 --MKEWLEGEDLSEELK-KENPFLRQELLGWLAEKLPT 167 (240) T ss_dssp --SHHHHSSSHHHHHHT-SCCHHHHHHHHHHHHHHGGG T ss_pred --hhHhccHHHHHHHHh-cCCHHHHHHHHHHHHHHHHh Confidence 11244 55566665 55677888888888877653 No 451 >4QMJ_A Cytoskeleton-associated protein 5; PROTEIN BINDING, TOG DOMAIN; 2.498A {Homo sapiens} Probab=75.47 E-value=0.21 Score=43.16 Aligned_cols=107 Identities=13% Similarity=0.065 Sum_probs=67.9 Template_Neff=12.600 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+........... ...+++.+...+.+.+..++..++.++..+..... T Consensus 59 ~~~~~l~~~l~d~~~~vr~~a~~~l~~l~~~~~~~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~----- 132 (240) T 4QMJ_A 59 ELPTALKGRLNDSNKILVQQTLNILQQLAVAMGPNIKQH-VKNLGIPIITVLGDSKNNVRAAALATVNAWAEQTG----- 132 (240) T ss_dssp THHHHHHHHTTCSSHHHHHHHHHHHHHHHHHHGGGGGGG-CCCCCHHHHHGGGCSSHHHHHHHHHHHHHHHHHHC----- T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHhcHHHHHH-HHHHHHHHHHHhhcCCHHHHHHHHHHHHHHHHHhC----- Confidence 344555556666777888888888888876533221111 12355666666666667788888888877765422 Q NP_000290.2 325 TRRQNGI--REAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL--~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...++ +.+...+. +.++.++..++.++..++.. T Consensus 133 --~~~~~~~~~l~~~l~-~~~~~~r~~~~~~l~~l~~~ 167 (240) T 4QMJ_A 133 --MKEWLEGEDLSEELK-KENPFLRQELLGWLAEKLPT 167 (240) T ss_dssp --SHHHHSSSHHHHHHH-SSCHHHHHHHHHHHHHHGGG T ss_pred --hhHhccHHHHHHHHh-cCCHHHHHHHHHHHHHHHHh Confidence 11244 55566665 55677888888888877653 No 452 >2IX8_A ELONGATION FACTOR 3A; NUCLEOTIDE-BINDING, PROTEIN BIOSYNTHESIS, PHOSPHORYLATION, ELONGATION; 6.0A {SACCHAROMYCES CEREVISIAE} Probab=75.43 E-value=0.22 Score=54.34 Aligned_cols=153 Identities=11% Similarity=0.112 Sum_probs=91.2 Template_Neff=11.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) .++.|+..+..+.++.++..++.+|..++..... .... .-..+++.|..++.+.+..++..|+.+|..++... T Consensus 128 ~l~~l~~~l~~~~~~~vr~~al~~L~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~d~~~~vr~~a~~~l~~l~~~~~ 201 (976) T 2IX8_A 128 LLPHLTNAIVETNKWQEKIAILAAFSAMVDAAKD-----QVAL-RMPELIPVLSETMWDTKKEVKAAATAAMTKATETVD 201 (976) T ss_dssp HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHSHH-----HHHH-HHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHSTTCC T ss_pred HHHHHHHHHhhcCCHHHHHHHHHHHHHHHHHHHH-----hHHh-hchhHHHHHHHhhcCCCHHHHHHHHHHHHHHHHhcC Confidence 4556666662135667778888888888754221 1111 12356777778887778888888888888877531 Q NP_000290.2 627 -LL-H----RVMG-----------------------------NQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 627 -e~-~----~ll~-----------------------------~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~ 671 (747) .. . .++. ..+++.+...+.+ .++.++..++.+|..++.. T Consensus 202 ~~~~~~~~~~l~~~l~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~l~~l~~~l~~------~~~~vr~~a~~~L~~l~~~ 275 (976) T 2IX8_A 202 NKDIERFIPSLIQCIADPTEVPETVHLLGATTFVAEVTPATLSIMVPLLSRGLNE------RETGIKRKSAVIIDNMCKL 275 (976) T ss_dssp SSTTCCCHHHHHHHHHCGGGHHHHHHHCSCTTCCSCCCHHHHHHHHHHHHHHHTS------SSHHHHHHHHHHHHHHHTT T ss_pred cHHHHHHHHHHHHHhcCCCCchHHHHHHHHhhhhccCCchhHHHHHHHHHccCCC------CChhHHHHHHHHHHHHHHH Confidence 00 0 0000 0233344444443 3567888888888888764 Q NP_000290.2 672 QPQLAK-QYFSSSMLNNIINLCRSSAS-PKAAEAARLLLSDMWS 713 (747) Q Consensus 672 s~e~~~-~Lve~giL~~Ll~LL~s~~d-~eVr~aAL~aLsnL~~ 713 (747) .+.... .-....+++.|...+.+. + +.++..++.+|..++. T Consensus 276 ~~~~~~~~~~~~~~~~~l~~~l~d~-~~~~vr~~a~~~l~~l~~ 318 (976) T 2IX8_A 276 VEDPQVIAPFLGKLLPGLKSNFATI-ADPEAREVTLRALKTLRR 318 (976) T ss_dssp CCCHHHHHHHHTTTHHHHHHHHHHC-CCHHHHHHHHHHHHHHHH T ss_pred cCCHHHHHHHHHHHHHHHHHhcCCC-CCHHHHHHHHHHHHHHHH Confidence 211110 001123566677777665 5 7888899999988865 No 453 >5XAH_A Importin-4; Histone, Chromatin, Assembly, PROTEIN TRANSPORT; HET: MSE; 3.004A {Homo sapiens} Probab=75.38 E-value=0.21 Score=46.90 Aligned_cols=162 Identities=12% Similarity=0.072 Sum_probs=86.9 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSG--------MSQLIGLKEKGLPQIARLLQS-GNSDVVRSGASL 618 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~--------~~~~llie~giI~~Ll~LL~s-~d~eVr~~AL~a 618 (747) +++.++..+. +.++.++..++.+|..++..... ... ..... .-..+++.+...+.+ .++.++..++.+ T Consensus 33 i~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-~~~~~~~~~~~~~~~~-~~~~~~~~l~~~l~~~~~~~~~~~~~~~ 109 (416) T 5XAH_A 33 VFEEVFKLLE-CPHLNVRKAAHEALGQFCCALHK-ACQSCPSEPNTAALQA-ALARVVPSYMQAVNRERERQVVMAVLEA 109 (416) T ss_dssp HHHHHHGGGS-CSCHHHHHHHHHHHHHHHHHHHH-HHTTSCCHHHHHHHHH-HHHHHHHHHHHHHTTCCCHHHHHHHHHH T ss_pred HHHHHHHHcC-CCCHHHHHHHHHHHHHHHHHHHH-HhccCCCCCCcHHHHH-HHHHHHHHHHHHHhhccHHHHHHHHHHH Confidence 4566667776 46778888999999888764211 000 00000 112455666666655 567788889999 Q NP_000290.2 619 LSNMSRHPLLH-R---VMGNQVFPEVTRLLTSHTG--------------NTSNSEDILSSACYTVRNLMASQ-PQLAKQY 679 (747) Q Consensus 619 LsnLa~~~e~~-~---ll~~giI~~Ll~LL~s~s~--------------~~~~d~eVr~~Al~aLsnLa~~s-~e~~~~L 679 (747) |..++...... . .....+++.+...+..... ....++.++..++.++..++... +.....+ T Consensus 110 l~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~ 189 (416) T 5XAH_A 110 LTGVLRSCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIPALAAAAGGDSFAPF 189 (416) T ss_dssp HHHHHHHTTHHHHCSTTHHHHHHHHHHHHHTTCSTTC-------------CHHHHHHHHHHHHHHHHHHHHHTSTTTHHH T ss_pred HHHHHHHhcccccCCccHHHHHHHHHHHHHhccchhcCCCcccccccccHHHHHHHHHHHHHHHHHHHHHHhCccchHHH Confidence 98887652111 0 1112345555555543100 00004567778888888887642 1111111 Q NP_000290.2 680 FSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 680 ve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) + ..+++.+...+....+..++..++.++..++. T Consensus 190 ~-~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~ 222 (416) T 5XAH_A 190 F-AGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQ 222 (416) T ss_dssp H-HHHHHHHHHTTSSSSCHHHHHHHHHHHHHHHH T ss_pred H-HHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHH Confidence 1 13455555555433135666777777776664 No 454 >5XAH_C Importin-4; Histone, Chromatin, Assembly, PROTEIN TRANSPORT; HET: MSE; 3.004A {Homo sapiens} Probab=75.38 E-value=0.21 Score=46.90 Aligned_cols=162 Identities=12% Similarity=0.072 Sum_probs=86.9 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSG--------MSQLIGLKEKGLPQIARLLQS-GNSDVVRSGASL 618 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~--------~~~~llie~giI~~Ll~LL~s-~d~eVr~~AL~a 618 (747) +++.++..+. +.++.++..++.+|..++..... ... ..... .-..+++.+...+.+ .++.++..++.+ T Consensus 33 i~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~~~~-~~~~~~~~~~~~~~~~-~~~~~~~~l~~~l~~~~~~~~~~~~~~~ 109 (416) T 5XAH_C 33 VFEEVFKLLE-CPHLNVRKAAHEALGQFCCALHK-ACQSCPSEPNTAALQA-ALARVVPSYMQAVNRERERQVVMAVLEA 109 (416) T ss_dssp HHHHHHHGGG-SSCHHHHHHHHHHHHHHHHHHHH-HHHHSCCHHHHHHHHH-HHHHHHHHHHHHHHHCCCHHHHHHHHHH T ss_pred HHHHHHHHcC-CCCHHHHHHHHHHHHHHHHHHHH-HhccCCCCCCcHHHHH-HHHHHHHHHHHHHhhccHHHHHHHHHHH Confidence 4566667776 46778888999999888764211 000 00000 112455666666655 567788889999 Q NP_000290.2 619 LSNMSRHPLLH-R---VMGNQVFPEVTRLLTSHTG--------------NTSNSEDILSSACYTVRNLMASQ-PQLAKQY 679 (747) Q Consensus 619 LsnLa~~~e~~-~---ll~~giI~~Ll~LL~s~s~--------------~~~~d~eVr~~Al~aLsnLa~~s-~e~~~~L 679 (747) |..++...... . .....+++.+...+..... ....++.++..++.++..++... +.....+ T Consensus 110 l~~l~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~a~~~l~~l~~~~~~~~~~~~ 189 (416) T 5XAH_C 110 LTGVLRSCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIPALAAAAGGDSFAPF 189 (416) T ss_dssp HHHHHHHHGGGGSCSTTHHHHHHHHHHHHHHTCSTTTC-----------CTTHHHHHHHHHHTHHHHHHHHHTSTTTHHH T ss_pred HHHHHHHhcccccCCccHHHHHHHHHHHHHhccchhcCCCcccccccccHHHHHHHHHHHHHHHHHHHHHHhCccchHHH Confidence 98887652111 0 1112345555555543100 00004567778888888887642 1111111 Q NP_000290.2 680 FSSSMLNNIINLCRSSASPKAAEAARLLLSDMWS 713 (747) Q Consensus 680 ve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~ 713 (747) + ..+++.+...+....+..++..++.++..++. T Consensus 190 ~-~~~~~~l~~~l~~~~~~~~~~~~~~~l~~l~~ 222 (416) T 5XAH_C 190 F-AGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQ 222 (416) T ss_dssp H-HHHHHHHHHTTSTTSCHHHHHHHHHHHHHHHH T ss_pred H-HHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHH Confidence 1 13455555555433135666777777776664 No 455 >5H2V_A Importin subunit beta-3, Ubiquitin-like-specific protease; nuclear import, PROTEIN TRANSPORT-HYDROLASE complex; 2.8A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=75.07 E-value=0.22 Score=53.62 Aligned_cols=154 Identities=16% Similarity=0.115 Sum_probs=91.6 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) .++.+...+. +.++.++..++.+|..++..... .... .-..+++.+...+.+.++.++..++.++..++... T Consensus 357 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 429 (1078) T 5H2V_A 357 LFQYLQQMIT-STEWRERFAAMMALSSAAEGCAD-----VLIG-EIPKILDMVIPLINDPHPRVQYGCCNVLGQISTDFS 429 (1078) T ss_dssp HHHHHHHHTT-CSCHHHHHHHHHHHHHHTTTTHH-----HHTT-SHHHHHHHHGGGGGCSSHHHHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhccHH-----HHHh-hHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHhhcc Confidence 4555555565 35677888888888888764321 1111 11356666777777777889999999999988652 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. .......+++.+...+.+. .++.++..++.+|..++...........-..++..+...+.+. ++.++..++ T Consensus 430 ~~~~~~~~~~~~~~l~~~l~~~-----~~~~~~~~a~~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~-~~~~~~~~~ 503 (1078) T 5H2V_A 430 PFIQRTAHDRILPALISKLTSE-----CTSRVQTHAAAALVNFSEFASKDILEPYLDSLLTNLLVLLQSN-KLYVQEQAL 503 (1078) T ss_dssp THHHHHHHHHHHHHHHHTTSTT-----SCHHHHHHHHHHHHHHHTTCCHHHHGGGHHHHHHHHHHHTTCS-SHHHHHHHH T ss_pred HHHHHHHHHhHHHHHHHHcccC-----CCHHHHHHHHHHHHHHHhcCChhhHHHHHHHHHHHHHHHHhCC-CHHHHHHHH Confidence 11 1111123555555555431 2567788888888888764321110011123455666666554 567777777 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .++..++.. T Consensus 504 ~~l~~l~~~ 512 (1078) T 5H2V_A 504 TTIAFIAEA 512 (1078) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHH Confidence 777776653 No 456 >6OWT_A AP-2 complex subunit alpha, AP-2; AP, HIV, Nef, trafficking, Protein;{Rattus norvegicus} Probab=74.95 E-value=0.24 Score=54.59 Aligned_cols=140 Identities=16% Similarity=0.153 Sum_probs=90.7 Template_Neff=11.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) +++.++.++. +.+...+..+..++..+...... ....++..|...+.+.++.++..|+.+|+++..... T Consensus 75 ~~~~l~~ll~-s~~~~~r~~~~~~l~~l~~~~~~----------~~~~ii~~l~~~l~~~~~~vr~~Al~~l~~~~~~~~ 143 (939) T 6OWT_A 75 GHMEAVNLLS-SNRYTEKQIGYLFISVLVNSNSE----------LIRLINNAIKNDLASRNPTFMGLALHCIANVGSREM 143 (939) T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHccCChH----------HHHHHHHHHHHHhcCCCHHHHHHHHHHHHHhcCHHH Confidence 3455666776 46667777777777777653221 112456667777777888899999999888764311 Q NP_000290.2 628 LHRVMGNQVFPEVTRLL--TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL--~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ...+++.+..++ .+ .++.++..++.+|..+....+... .....++.|..++.+. +..++..++ T Consensus 144 -----~~~l~~~l~~~l~~~~------~~~~vR~~a~~~L~~l~~~~~~~~---~~~~~~~~l~~lL~d~-~~~vr~~a~ 208 (939) T 6OWT_A 144 -----AEAFAGEIPKILVAGD------TMDSVKQSAALCLLRLYRTSPDLV---PMGDWTSRVVHLLNDQ-HLGVVTAAT 208 (939) T ss_pred -----HHHHHHHHHHHHcCCC------CCHHHHHHHHHHHHHHHHHCchhc---ChhhHHHHHHHHhcCC-CHHHHHHHH Confidence 112444555555 33 367889999999999876433221 1234567777777765 677888888 Q NP_000290.2 706 LLLSDMWS 713 (747) Q Consensus 706 ~aLsnL~~ 713 (747) .+|..+.. T Consensus 209 ~~L~~l~~ 216 (939) T 6OWT_A 209 SLITTLAQ 216 (939) T ss_pred HHHHHHHH Confidence 88877765 No 457 >4G3A_B CLIP-associating protein; TOG domain, HEAT repeat, MAP; HET: GOL; 1.994A {Drosophila melanogaster} Probab=74.93 E-value=0.22 Score=42.89 Aligned_cols=107 Identities=15% Similarity=0.166 Sum_probs=71.3 Template_Neff=12.600 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIA-RLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll-~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) .++.++..+. +.+..++..++.+|..+...... ....+++.+. .++.+.++.++..++.++..++... T Consensus 91 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~~~----------~~~~~~~~l~~~~l~~~~~~~r~~a~~~l~~l~~~~ 159 (237) T 4G3A_B 91 VLPHVIDRLG-DSRDTVREKAQLLLRDLMEHRVL----------PPQALIDKLATSCFKHKNAKVREEFLQTIVNALHEY 159 (237) T ss_dssp HHHHHHHHHT-CSCHHHHHHHHHHHHHHHHTTSS----------CHHHHHHHHHHHHTTCSCHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHHcCCC----------CHHHHHHHHHHHHhhCCCHHHHHHHHHHHHHHHHHh Confidence 5666777776 35667788888888888753111 0123556666 6777777888999999998887652 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMAS 671 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~ 671 (747) .........+++.+...+.+ .++.++..++.++..+... T Consensus 160 ~~~~~~~~~~~~~l~~~l~~------~~~~vr~~a~~~l~~l~~~ 198 (237) T 4G3A_B 160 GTQQLSVRVYIPPVCALLGD------PTVNVREAAIQTLVEIYKH 198 (237) T ss_dssp HHHHCCCGGGHHHHHHHTTC------SSHHHHHHHHHHHHHHHHH T ss_pred CCccccHHHHHHHHHHHHCC------CCHHHHHHHHHHHHHHHHH Confidence 11111113456667777765 3678899999999988764 No 458 >4XL5_C Green fluorescent protein, bGFP-A; AlphaRep Scaffold, Complex, EGFP, PROTEIN; HET: CRO; 2.0A {Aequorea victoria} Probab=74.58 E-value=0.23 Score=43.80 Aligned_cols=121 Identities=12% Similarity=0.165 Sum_probs=73.5 Template_Neff=12.400 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.++..+... ..++.+...+.+.++.++..++.+|..+... T Consensus 139 ~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~----------------~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~~-- 199 (263) T 4XL5_C 139 AVEPLIKALK-DEDPWVRLTAARALGQIGDE----------------RAVEPLIKALKDEDASVRKAAAVALGQIGDE-- 199 (263) T ss_dssp GHHHHHHHTT-CSSHHHHHHHHHHHHHHCCG----------------GGHHHHHHHTTCSSHHHHHHHHHHHHHHCCG-- T ss_pred hHHHHHHHhh-CCCHHHHHHHHHHHHhhCCH----------------HHHHHHHHHhcCCCHHHHHHHHHHHHHhCCh-- Confidence 4455666666 35667777777777655431 2234455566666677788888877766431 Q NP_000290.2 628 LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLL 707 (747) Q Consensus 628 ~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~a 707 (747) ..++.+..++.+ .+..++..++.+|..+... ...+.+..++.+. ++.++..++.+ T Consensus 200 -------~~~~~l~~~l~~------~~~~~~~~a~~~l~~~~~~-----------~~~~~l~~~~~~~-~~~vr~~a~~~ 254 (263) T 4XL5_C 200 -------RAVEPLIKALKD------EDEYVRQRAASALGKIGGE-----------RVRAAMEKLAEPA-PGFARKVAVNY 254 (263) T ss_dssp -------GGHHHHHHHTTC------SSHHHHHHHHHHHHHHCHH-----------HHHHHHHHHTTTC-CHHHHHHHHHH T ss_pred -------hhHHHHHHHhcC------CCHHHHHHHHHHHHhhCcH-----------HHHHHHHHHhcCC-CcHHHHHHHHH Confidence 234455555554 2566777888888776542 2334444555544 66788888888 Q NP_000290.2 708 LSDMW 712 (747) Q Consensus 708 LsnL~ 712 (747) |..+. T Consensus 255 l~~~~ 259 (263) T 4XL5_C 255 LETHK 259 (263) T ss_dssp HHHCC T ss_pred HHHHH Confidence 77654 No 459 >4FDD_A Transportin-1, RNA-binding protein FUS; HEAT repeats, Karyopherin, nuclear import; 2.3A {Homo sapiens} Probab=74.48 E-value=0.23 Score=51.35 Aligned_cols=155 Identities=9% Similarity=0.106 Sum_probs=92.6 Template_Neff=13.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIG--LKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~ll--ie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+...+. +.++.++..++.+|..+...... ......+ .-..+++.+...+.+.++.++..++.+|..++.. T Consensus 129 ~~~~l~~~l~-~~~~~~~~~al~~l~~l~~~~~~---~~~~~~~~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 204 (852) T 4FDD_A 129 LLPKLCSLLD-SEDYNTCEGAFGALQKICEDSAE---ILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIIS 204 (852) T ss_dssp HHHHHHHHHS-CSSHHHHHHHHHHHHHHHHHHTT---HHHHCSSSSCHHHHHHHHTTTTTCSSHHHHHHHHHHHHTTTTT T ss_pred HHHHHHHHHc-CCCHHHHHHHHHHHHHHHHHHHh---hcchhhccHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHH Confidence 3455555565 35667777888888877753210 0000000 1134566677777777788899999999888765 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) ... .......+++.+...+.+ .++.++..++.++..+....+....... ..+++.+...+.+. ++.++..+ T Consensus 205 ~~~~~~~~~~~~~~~l~~~l~~------~~~~~r~~~~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~-~~~v~~~a 276 (852) T 4FDD_A 205 RTQALMLHIDSFIENLFALAGD------EEPEVRKNVCRALVMLLEVRMDRLLPHM-HNIVEYMLQRTQDQ-DENVALEA 276 (852) T ss_dssp TCHHHHTSHHHHHHHHHHHHTC------CCHHHHHHHHHHHHHHHHHCHHHHGGGH-HHHHHHHHHHHTCS-SHHHHHHH T ss_pred hHHHHHHhHHHHHHHHHHHcCC------CCHHHHHHHHHHHHHHHHHcHHHHHHhH-HHHHHHHHHhcCCC-CHHHHHHH Confidence 211 111112355556666654 3567888899999888765332211111 23456666666655 67788888 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.+|..++.. T Consensus 277 ~~~l~~l~~~ 286 (852) T 4FDD_A 277 CEFWLTLAEQ 286 (852) T ss_dssp HHHHHHHTTS T ss_pred HHHHHHHhcC Confidence 8888887754 No 460 >4D4Z_A DEOXYHYPUSINE HYDROXYLASE (E.C.1.14.99.29); OXIDOREDUCTASE, EIF-5A, HYPUSINE; HET: B3P, GOL; 1.7A {HOMO SAPIENS} Probab=74.40 E-value=0.23 Score=44.22 Aligned_cols=124 Identities=11% Similarity=0.101 Sum_probs=69.5 Template_Neff=12.700 Q NP_000290.2 546 SDAIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) ...++.|...+. +.+ +.++..++.+|..+.. ...++.+...+.+.++.++..++.+|..+. T Consensus 9 ~~~~~~l~~~l~-~~~~~~~~r~~a~~~l~~~~~----------------~~~~~~l~~~l~~~~~~~r~~a~~~l~~~~ 71 (294) T 4D4Z_A 9 EQEVDAIGQTLV-DPKQPLQARFRALFTLRGLGG----------------PGAIAWISQAFDDDSALLKHELAYCLGQMQ 71 (294) T ss_dssp HHHHHHHHHHHH-CTTSCHHHHHHHHHHHHHHCS----------------HHHHHHHHHGGGCSCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHHc-CCCCCHHHHHHHHHHHHhhcC----------------hhHHHHHHHHhCCCCHHHHHHHHHHHHhcC Confidence 345666777776 344 4577777777766532 123445556666667777888877777664 Q NP_000290.2 624 RHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 624 ~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) .. ..++.+..++.+. ..++.++..++.+|..+... ..++.+...+.+. ++.++.. T Consensus 72 ~~---------~~~~~l~~~l~~~----~~~~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~v~~~ 126 (294) T 4D4Z_A 72 DA---------RAIPMLVDVLQDT----RQEPMVRHEAGEALGAIGDP-----------EVLEILKQYSSDP-VIEVAET 126 (294) T ss_dssp CG---------GGHHHHHHHHHCT----TSCHHHHHHHHHHHHHHCCG-----------GGHHHHHHHTTCS-SHHHHHH T ss_pred Cc---------chHHHHHHHhhCC----CCCHHHHHHHHHHHHHhCCH-----------HHHHHHHHHccCC-CchHHHH Confidence 31 2334455555441 01456777777777766431 1233444445444 5556666 Q NP_000290.2 704 ARLLLSDM 711 (747) Q Consensus 704 AL~aLsnL 711 (747) ++.++..+ T Consensus 127 a~~~l~~~ 134 (294) T 4D4Z_A 127 CQLAVRRL 134 (294) T ss_dssp HHHHHHHH T ss_pred HHHHHHHH Confidence 65555544 No 461 >4D50_A DEOXYHYPUSINE HYDROXYLASE (E.C.1.14.99.29); OXIDOREDUCTASE; HET: GAI; 1.7A {HOMO SAPIENS} Probab=74.40 E-value=0.23 Score=44.22 Aligned_cols=124 Identities=11% Similarity=0.101 Sum_probs=69.5 Template_Neff=12.700 Q NP_000290.2 546 SDAIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 546 ~G~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) ...++.|...+. +.+ +.++..++.+|..+.. ...++.+...+.+.++.++..++.+|..+. T Consensus 9 ~~~~~~l~~~l~-~~~~~~~~r~~a~~~l~~~~~----------------~~~~~~l~~~l~~~~~~~r~~a~~~l~~~~ 71 (294) T 4D50_A 9 EQEVDAIGQTLV-DPKQPLQARFRALFTLRGLGG----------------PGAIAWISQAFDDDSALLKHELAYCLGQMQ 71 (294) T ss_dssp HHHHHHHHHHHH-CTTSCHHHHHHHHHHHHHHCS----------------HHHHHHHHHGGGSSCHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHHc-CCCCCHHHHHHHHHHHHhhcC----------------hhHHHHHHHHhCCCCHHHHHHHHHHHHhcC Confidence 345666777776 344 4577777777766532 123445556666667777888877777664 Q NP_000290.2 624 RHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEA 703 (747) Q Consensus 624 ~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~a 703 (747) .. ..++.+..++.+. ..++.++..++.+|..+... ..++.+...+.+. ++.++.. T Consensus 72 ~~---------~~~~~l~~~l~~~----~~~~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~v~~~ 126 (294) T 4D50_A 72 DA---------RAIPMLVDVLQDT----RQEPMVRHEAGEALGAIGDP-----------EVLEILKQYSSDP-VIEVAET 126 (294) T ss_dssp CG---------GGHHHHHHHHHCT----TSCHHHHHHHHHHHHHHCCG-----------GGHHHHHHHTTCS-SHHHHHH T ss_pred Cc---------chHHHHHHHhhCC----CCCHHHHHHHHHHHHHhCCH-----------HHHHHHHHHccCC-CchHHHH Confidence 31 2334455555441 01456777777777766431 1233444445444 5556666 Q NP_000290.2 704 ARLLLSDM 711 (747) Q Consensus 704 AL~aLsnL 711 (747) ++.++..+ T Consensus 127 a~~~l~~~ 134 (294) T 4D50_A 127 CQLAVRRL 134 (294) T ss_dssp HHHHHHHH T ss_pred HHHHHHHH Confidence 65555544 No 462 >6QH5_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=74.19 E-value=0.24 Score=50.25 Aligned_cols=69 Identities=16% Similarity=0.194 Sum_probs=49.1 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLM--GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL--~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+...+ . +.++.++..++.+|..+....+. .......++.+..++.+.++.++..++.+|..+... T Consensus 147 l~~~l~~~l~~~-~~~~~vr~~a~~~L~~l~~~~~~--------~~~~~~~~~~l~~~l~~~~~~vr~~a~~~L~~l~~~ 217 (621) T 6QH5_A 147 FAGEIPKILVAG-DTMDSVKQSAALCLLRLYRTSPD--------LVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQK 217 (621) T ss_pred HHHHHHHHhcCC-CCCHHHHHHHHHHHHHHHHhChH--------HccHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHh Confidence 355566666 5 46778888999999988764221 111245677788888888888999999999888764 No 463 >5LPH_B Centrosomal protein of 104 kDa; TOG domain, HEAT repeat, Tubulin; HET: MSE; 2.25A {Homo sapiens} Probab=74.03 E-value=0.26 Score=45.88 Aligned_cols=155 Identities=10% Similarity=0.057 Sum_probs=88.9 Template_Neff=10.900 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLM---SSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~---s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) ++.+...+. +.+..++..++.++..++...... ... .... .-..+++.|+..+.+.++.++..+..+|..++.. T Consensus 94 ~~~l~~~l~-d~~~~v~~~a~~~l~~l~~~~~~~~~~~~~-~~~~-~l~~ll~~ll~~l~d~~~~vr~~a~~~l~~l~~~ 170 (288) T 5LPH_B 94 VFLVRRAIK-DIVTSVFQASLKLLKMIITQYIPKHKLSKL-ETAH-CVERTIPVLLTRTGDSSARLRVTAANFIQEMALF 170 (288) T ss_pred HHHHHHHhC-CCCHHHHHHHHHHHHHHHHHHcccCCCCHH-HHHH-HHHHHHHHHHHHhCCCcHHHHHHHHHHHHHHHcC Confidence 444555565 466778888888888776532000 000 0011 1234667777777777788888899888888765 Q NP_000290.2 626 PLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 626 ~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) ..... ...++..+...+... .++.++..++.+|..++...........-..+++.+...+.+. +..+|..+. T Consensus 171 ~~~~~--~~~v~~~l~~~l~~~-----~~~~~~~~~l~~l~~l~~~~~~~~~~~~~~~i~~~l~~~l~~~-~~~VR~~a~ 242 (288) T 5LPH_B 171 KEVKS--LQIIPSYLVQPLKAN-----SSVHLAMSQMGLLARLLKDLGTGSSGFTIDNVMKFSVSALEHR-VYEVRETAV 242 (288) T ss_pred CCCCc--hhhHHHHHhhccccC-----CCHHHHHHHHHHHHHHHHHHCCCCCCccHHHHHHHHHHHhCCC-CHHHHHHHH Confidence 21100 011223332333321 2466777788888877654322111111224567777777766 789999999 Q NP_000290.2 706 LLLSDMWSS 714 (747) Q Consensus 706 ~aLsnL~~~ 714 (747) .++..+... T Consensus 243 ~~l~~l~~~ 251 (288) T 5LPH_B 243 RIILDMYRQ 251 (288) T ss_pred HHHHHHHHH Confidence 998887653 No 464 >1QBK_B STRUCTURE OF THE KARYOPHERIN BETA2-RAN; HEAT REPEATS, NUCLEAR TRANSPORT PROTEIN; HET: GNP; 3.0A {Homo sapiens} SCOP: a.118.1.1 Probab=73.90 E-value=0.24 Score=51.58 Aligned_cols=156 Identities=9% Similarity=0.104 Sum_probs=93.2 Template_Neff=13.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLI--GLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~l--lie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+...+. +.++.++..++.+|..++..... ...... -.-..+++.+...+.+.++.++..++.+|..+... T Consensus 129 ~~~~l~~~l~-~~~~~~~~~al~~l~~l~~~~~~---~~~~~~~~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 204 (890) T 1QBK_B 129 LLPKLCSLLD-SEDYNTCEGAFGALQKICEDSAE---ILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIIS 204 (890) T ss_pred HHHHHHHHhc-CCChhHHHHHHHHHHHHHHHHHH---hcchhhccHhHHhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHH Confidence 4555666665 35667777888888887754221 000000 01134566677777777788899999999988765 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) ... .......+++.+...+.+ .+..++..++.+|..++...+....... ..+++.+...+.+. ++.++..+ T Consensus 205 ~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~-~~~v~~~a 276 (890) T 1QBK_B 205 RTQALMLHIDSFTENLFALAGD------EEPEVRKNVCRALVMLLEVRMDRLLPHM-HNIVEYMLQRTQDQ-DENVALEA 276 (890) T ss_pred hcHHHHHcHHHHHHHHHHHcCC------CCHHHHHHHHHHHHHHHHhCHHHHHHhH-HHHHHHHHHHhcCC-CHHHHHHH Confidence 211 111112345555555554 2567788888888888765332221111 23456666666655 67788888 Q NP_000290.2 705 RLLLSDMWSSK 715 (747) Q Consensus 705 L~aLsnL~~~~ 715 (747) +.++..+.... T Consensus 277 ~~~l~~l~~~~ 287 (890) T 1QBK_B 277 CEFWLTLAEQP 287 (890) T ss_pred HHHHHHHhcCh Confidence 88888887653 No 465 >3W3W_A Importin subunit beta-3, Protein STE12; HEAT repeat, nuclear import, PROTEIN; 2.2A {Saccharomyces cerevisiae} Probab=73.86 E-value=0.24 Score=53.17 Aligned_cols=153 Identities=16% Similarity=0.154 Sum_probs=90.7 Template_Neff=13.000 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH-P 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~-~ 626 (747) .++.+...+. +.++.++..++.+|..++..... .... .-..+++.+...+.+.++.++..++.++..++.. . T Consensus 357 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~-~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 429 (1078) T 3W3W_A 357 LFQYLQQMIT-STEWRERFAAMMALSSAAEGCAD-----VLIG-EIPKILDMVIPLINDPHPRVQYGCCNVLGQISTDFS 429 (1078) T ss_dssp HHHHHHHHHT-CSCHHHHHHHHHHHHHHTTTTHH-----HHTT-CHHHHHHHHGGGGGCSSHHHHHHHHHHHHHHHHHTT T ss_pred HHHHHHHHhc-CCCHHHHHHHHHHHHHHHhccHH-----HHHh-hHHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHhcc Confidence 4455555555 35677888888888888764221 1111 1135666677777777788999999999998865 1 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) .. .......+++.+...+.+. .+..++..++.+|..++..... ..... -..++..+...+.+. +..++..+ T Consensus 430 ~~~~~~~~~~~~~~l~~~l~~~-----~~~~~r~~a~~~l~~l~~~~~~~~~~~~-~~~i~~~l~~~l~~~-~~~~~~~~ 502 (1078) T 3W3W_A 430 PFIQRTAHDRILPALISKLTSE-----CTSRVQTHAAAALVNFSEFASKDILEPY-LDSLLTNLLVLLQSN-KLYVQEQA 502 (1078) T ss_dssp THHHHHHHHHHHHHHHHHTSTT-----SCHHHHHHHHHHHHHHHHTCCHHHHGGG-HHHHHHHHHHHHTCS-SHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHcccC-----CCHHHHHHHHHHHHHHHhcCChhhHHHH-HHHHHHHHHHHHhcC-CHHHHHHH Confidence 11 1011123555555555431 2567788888888888764321 11111 123455666666544 56677777 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.++..++.. T Consensus 503 ~~~l~~l~~~ 512 (1078) T 3W3W_A 503 LTTIAFIAEA 512 (1078) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 7777776643 No 466 >1IBR_B RAN IMPORTIN BETA SUBUNIT; SMALL GTPASE NUCLEAR TRANSPORT; HET: GNP; 2.3A {Homo sapiens} SCOP: a.118.1.1 Probab=73.63 E-value=0.25 Score=47.09 Aligned_cols=158 Identities=12% Similarity=0.052 Sum_probs=89.8 Template_Neff=12.900 Q NP_000290.2 547 DAIRTYLNLMGKS-KKDATLEACAGALQNLTASKGLMSS------G-MSQLIGLKEKGLPQIARLLQSGNSDVVRSGASL 618 (747) Q Consensus 547 G~I~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s~~~s~------~-~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~a 618 (747) +.++.++.++.+. .++.++..|+.+|.++...... .. . .....-....+.+.++..+.+. +.++..++.+ T Consensus 35 ~~~~~l~~~l~~~~~~~~vr~~a~~~l~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~i~~~l~~~l~~~-~~~~~~~~~~ 112 (462) T 1IBR_B 35 TFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDP-DIKAQYQQRWLAIDANARREVKNYVLQTLGTE-TYRPSSASQC 112 (462) T ss_dssp HHHHHHHHHHHCTTSCHHHHHHHHHHHHHHHCCSSH-HHHHHHHHHHHTSCHHHHHHHHHHHHHHTTCC-CSSSCSHHHH T ss_pred HHHHHHHHHHhCCCCCHHHHHHHHHHHHHHhhcCCH-HHHHHHHHhHhcCCHHHHHHHHHHHHHHHCCC-CCChhHHHHH Confidence 4566677777621 3567888888888887653210 00 0 0000001123445555555442 3457777788 Q NP_000290.2 619 LSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNS--EDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA 696 (747) Q Consensus 619 LsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d--~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~ 696 (747) ++.++...... .....+++.+...+.+ .+ +.++..++.+|..+...............+++.+...+.+. T Consensus 113 l~~l~~~~~~~-~~~~~~~~~l~~~l~~------~~~~~~~~~~~l~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~- 184 (462) T 1IBR_B 113 VAGIACAEIPV-NQWPELIPQLVANVTN------PNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKE- 184 (462) T ss_dssp HHHHHHHHGGG-TCCTTHHHHHHHHHHC------TTCCHHHHHHHHHHHHHHHHHSCGGGTGGGHHHHHHHHHHHHSTT- T ss_pred HHHHHhhcCCh-hhcccHHHHHHHHhhC------CCCchHHHHHHHHHHHHHhhcCCHHHHHHHHHHHHHHHHHHHhCC- Confidence 88777541110 0112356666666665 23 67888899999888764322111111224567777777765 Q NP_000290.2 697 S--PKAAEAARLLLSDMWSS 714 (747) Q Consensus 697 d--~eVr~aAL~aLsnL~~~ 714 (747) + ..++..++.++..++.. T Consensus 185 ~~~~~vr~~a~~~l~~l~~~ 204 (462) T 1IBR_B 185 EPSNNVKLAATNALLNSLEF 204 (462) T ss_dssp CCCHHHHHHHHHHHHHHTTT T ss_pred CCCHHHHHHHHHHHHHHHHH Confidence 4 78889999999888654 No 467 >5VCH_A Kap123; Bidding yeast karyopherin, 23 HEAT; HET: MSE; 2.35A {Kluyveromyces lactis} Probab=73.42 E-value=0.26 Score=53.37 Aligned_cols=153 Identities=15% Similarity=0.124 Sum_probs=92.7 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) .++.+...+. +.++.++..++.+|..++..... ..... -..+++.+...+.+.++.++..++.++..++... T Consensus 361 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 433 (1116) T 5VCH_A 361 IIEHLPTMLS-SSNPFERRSILLAISVLVTGSPD-----YTLSQ-FDKIIPATVTGLKDSEAVVQLAALKCIVQLSTNLQ 433 (1116) T ss_dssp HHHHHHHHHH-CSCHHHHHHHHHHHHHHTTTCHH-----HHHHT-HHHHHHHHHHHHTCSSHHHHHHHHHHHHHHHHHSH T ss_pred HHHHHHHHhh-CCCHHHHHHHHHHHHHHHhcCHH-----HHHHh-HHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHhcH Confidence 4555566665 35677788888888888764321 11111 1356677777777777889999999999888652 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSMLNNIINLCRS-SASPKAAEAA 704 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~giL~~Ll~LL~s-~~d~eVr~aA 704 (747) .........+++.+...+... .+..++..++.+|..++..... ...... ..+++.+...+.+ . ++.++..+ T Consensus 434 ~~~~~~~~~~~~~l~~~l~~~-----~~~~v~~~a~~~l~~l~~~~~~~~~~~~~-~~~~~~l~~~l~~~~-~~~~~~~~ 506 (1116) T 5VCH_A 434 DEVARYHEQYLPLVIDIIDSA-----KHVVIYKYATLALDGLLEFIAHNDIIKYL-DPLMNKLFQMLETQQ-SPKLRAAI 506 (1116) T ss_dssp HHHHTTHHHHHHHHHHHHHTC-----CSHHHHHHHHHHHHHHHHTSCHHHHHHHH-HHHHHHHHHHHHHCC-CHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHhccC-----CCHHHHHHHHHHHHHHHhhCCHhhHHHHH-HHHHHHHHHHHhcCC-CHHHHHHH Confidence 111111123555566665541 2567788888888888764222 111111 2356666666665 3 56777778 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.++..++.. T Consensus 507 ~~~l~~l~~~ 516 (1116) T 5VCH_A 507 VSAIGSCAFA 516 (1116) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 8888777653 No 468 >6QH7_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: SEP; 3.4A {Rattus norvegicus} Probab=73.36 E-value=0.26 Score=49.97 Aligned_cols=69 Identities=16% Similarity=0.194 Sum_probs=49.2 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLM--GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL--~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+...+ . +.++.++..++.+|..+....+. .......++.|..++.+.++.++..++.+|..+... T Consensus 147 l~~~l~~~l~~~-~~~~~vr~~a~~~L~~~~~~~~~--------~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 217 (621) T 6QH7_A 147 FAGEIPKILVAG-DTMDSVKQSAALCLLRLYRTSPD--------LVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQK 217 (621) T ss_dssp HTTHHHHHHTTS-CCCHHHHHHHHHHHHHHHHHCGG--------GCCCCTTHHHHHHGGGCSSHHHHHHHHHHHHHHHTT T ss_pred HHhhHHHHHHcC-CCCHHHHHHHHHHHHHHHHHChh--------hcCccchHHHHHHHhcCCCHHHHHHHHHHHHHHHHh Confidence 455566666 5 46778888999999988764221 111245677788888888888999999999888764 No 469 >2JKT_A AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ALTERNATIVE SPLICING, PHOSPHOPROTEIN, PHOSPHORYLATION, PROTEIN; HET: SEP, SO4; 3.4A {MUS MUSCULUS} Probab=73.28 E-value=0.27 Score=49.85 Aligned_cols=69 Identities=16% Similarity=0.194 Sum_probs=49.0 Template_Neff=12.300 Q NP_000290.2 548 AIRTYLNLM--GKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL--~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+...+ . +.++.++..++.+|..+....+. .......++.|..++.+.++.++..++.+|..+... T Consensus 147 l~~~l~~~l~~~-~~~~~vr~~a~~~L~~~~~~~~~--------~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 217 (623) T 2JKT_A 147 FAGEIPKILVAG-DTMDSVKQSAALCLLRLYRTSPD--------LVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQK 217 (623) T ss_dssp HTTHHHHHHHCT-TSCHHHHHHHHHHHHHHHHHCTT--------TCCCCTHHHHHHGGGGCSSHHHHHHHHHHHHHHHTT T ss_pred HHHhHHHHHHcC-CCCHHHHHHHHHHHHHHHHHChh--------hcCccchHHHHHHHhcCCCHHHHHHHHHHHHHHHHH Confidence 345566666 5 46778888999999888764221 111245677888888888888999999999888764 No 470 >1GCJ_B IMPORTIN-BETA; HEAT REPEAT MOTIF, NUCLEAR PORE-TARGETING; HET: MSE; 2.6A {Mus musculus} SCOP: a.118.1.1 Probab=73.02 E-value=0.27 Score=46.99 Aligned_cols=158 Identities=12% Similarity=0.055 Sum_probs=87.6 Template_Neff=12.800 Q NP_000290.2 547 DAIRTYLNLMGKS-KKDATLEACAGALQNLTASKGLMSS------G-MSQLIGLKEKGLPQIARLLQSGNSDVVRSGASL 618 (747) Q Consensus 547 G~I~~LL~LL~ss-~d~eVr~~AL~aL~nLs~~s~~~s~------~-~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~a 618 (747) +.+..++..+.++ .+..++..|+.+|.++...... .. . .....-....+.+.|+..+.+. ..++..++.+ T Consensus 41 ~~~~~l~~~l~~~~~~~~~r~~a~~~l~~~~~~~~~-~~~~~~~~~~~~l~~~~~~~l~~~l~~~l~~~-~~~r~~~~~~ 118 (460) T 1GCJ_B 41 TFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDP-DIKAQYQQRWLAIDANARREVKNYVLQTLGTE-TYRPSSASQC 118 (460) T ss_dssp HHHHHHHHHHSCTTSCHHHHHHHHHHHHTTTCCSSH-HHHHHHHHHHHHSCHHHHHHHHHHHHHHTTCC-CSSSCHHHHH T ss_pred HHHHHHHHHHhCCCCCHHHHHHHHHHHHHhccCCCH-HHHHHHHHHHHhCCHHHHHHHHHHHHHHHcCC-CCChhHHHHH Confidence 3455666666521 2456777777888876643110 00 0 0000001233455566666543 3477778888 Q NP_000290.2 619 LSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNS--EDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSA 696 (747) Q Consensus 619 LsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d--~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~ 696 (747) +..++...... .....+++.+...+.+ .+ +.++..++.+|..+...............+++.+...+.+. T Consensus 119 l~~l~~~~~~~-~~~~~~~~~l~~~l~~------~~~~~~~~~~~l~~l~~l~~~~~~~~~~~~~~~~~~~l~~~l~~~- 190 (460) T 1GCJ_B 119 VAGIACAEIPV-SQWPELIPQLVANVTN------PNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKE- 190 (460) T ss_dssp HHHHHHHHGGG-TCCTTHHHHHHHHHHC------TTCCHHHHHHHHHHHHHHHHHSCHHHHGGGHHHHHHHHHHHHCTT- T ss_pred HHHHHHHhCCc-cccchHHHHHHHHhhC------CCCcHHHHHHHHHHHHHHhhhCCHHHhHHHHHHHHHHHHHHHhCC- Confidence 88777541111 0112356666666665 23 67888899999888764221111111224566777777655 Q NP_000290.2 697 S--PKAAEAARLLLSDMWSS 714 (747) Q Consensus 697 d--~eVr~aAL~aLsnL~~~ 714 (747) + ..++..++.++..+... T Consensus 191 ~~~~~vr~~a~~~l~~~~~~ 210 (460) T 1GCJ_B 191 EPSNNVKLAATNALLNSLEF 210 (460) T ss_dssp CSCHHHHHHHHHHHHHHTTT T ss_pred CCCHHHHHHHHHHHHHHHHH Confidence 4 78888888888887653 No 471 >1OYZ_A X-RAY STRUCTURE OF YB61_HAEIN NORTHEAST; STRUCTURAL GENOMICS, PSI, Protein Structure; 2.1A {Escherichia coli} SCOP: a.118.1.16 Probab=72.96 E-value=0.27 Score=43.42 Aligned_cols=121 Identities=14% Similarity=0.056 Sum_probs=74.4 Template_Neff=12.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP 626 (747) Q Consensus 547 G~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~ 626 (747) ..++.+...+. +.++.++..++.++..+.... ...++.+...+.+.++.++..++.+|..+... T Consensus 159 ~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~~~~--------------~~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~~- 222 (280) T 1OYZ_A 159 ATIPLLINLLK-DPNGDVRNWAAFAININKYDN--------------SDIRDCFVEMLQDKNEEVRIEAIIGLSYRKDK- 222 (280) T ss_dssp CCHHHHHHHHT-CSSHHHHHHHHHHHHHHTCCC--------------HHHHHHHHHHTTCSCHHHHHHHHHHHHHTTCG- T ss_pred hhHHHHHHHHc-CCCHHHHHHHHHHHHhhcCCC--------------hHHHHHHHHHhcCCCHHHHHHHHHHHhccCCh- Confidence 34566677776 356677777777776553321 13455566667777778888888888776532 Q NP_000290.2 627 LLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARL 706 (747) Q Consensus 627 e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~ 706 (747) ..++.+...+.+ +.++..++.+|..+... ..++.|...+.+..++.++..++. T Consensus 223 --------~~~~~l~~~l~~--------~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~~~~~vr~~a~~ 275 (280) T 1OYZ_A 223 --------RVLSVLCDELKK--------NTVYDDIIEAAGELGDK-----------TLLPVLDTMLYKFDDNEIITSAID 275 (280) T ss_dssp --------GGHHHHHHHHTS--------SSCCHHHHHHHHHHCCG-----------GGHHHHHHHHTTSSCCHHHHHHHH T ss_pred --------hHHHHHHHHhCC--------ccHHHHHHHHHHHhcch-----------hHHHHHHHHHhcCCCHHHHHHHHH Confidence 234444455543 25677777777776531 245566666665226677888877 Q NP_000290.2 707 LLSD 710 (747) Q Consensus 707 aLsn 710 (747) +|.. T Consensus 276 ~l~~ 279 (280) T 1OYZ_A 276 KLKR 279 (280) T ss_dssp HHTC T ss_pred HHhc Confidence 7764 No 472 >2JKT_A AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2; ALTERNATIVE SPLICING, PHOSPHOPROTEIN, PHOSPHORYLATION, PROTEIN; HET: SEP, SO4; 3.4A {MUS MUSCULUS} Probab=72.80 E-value=0.28 Score=49.69 Aligned_cols=67 Identities=12% Similarity=0.101 Sum_probs=35.9 Template_Neff=12.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-s~d~eVr~~AL~aLsnLa 623 (747) .++.+..++. +.+..++..++.+|..+...... ... -...++.++..+. +.++.++..++.+|..+. T Consensus 330 ~~~~l~~~l~-~~~~~vr~~a~~~L~~l~~~~~~------~~~--~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~ 397 (623) T 2JKT_A 330 ACNQLGQFLQ-HRETNLRYLALESMCTLASSEFS------HEA--VKTHIETVINALKTERDVSVRQRAVDLLYAMC 397 (623) T ss_dssp HHHHHHHHHH-SSCSHHHHHHHHHHHHHTTCSSS------CSG--GGGGHHHHHHHHHHCCSHHHHHHHHHHHHTTC T ss_pred HHHHHHHHhh-CCCchHHHHHHHHHHHHHcCcCC------HHH--HHHHHHHHHHHHhcCCCHHHHHHHHHHHHHhc Confidence 3455556665 35566677777777766643210 011 1123445555555 555666666666666653 No 473 >5VE8_B Kap123, Histone H3; Bidding yeast karyopherin, 23 HEAT; HET: MSE; 2.7A {Kluyveromyces lactis} Probab=72.66 E-value=0.27 Score=53.10 Aligned_cols=153 Identities=15% Similarity=0.129 Sum_probs=92.5 Template_Neff=12.900 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPL 627 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e 627 (747) .++.+...+. +.++.++..++.+|..++..... ..... -..+++.+...+.+.++.++..++.++..++.... T Consensus 361 ~~~~l~~~l~-~~~~~~r~~a~~~l~~l~~~~~~-----~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~ 433 (1116) T 5VE8_B 361 IIEHLPTMLS-SSNPFERRSILLAISVLVTGSPD-----YTLSQ-FDKIIPATVTGLKDSEAVVQLAALKCIVQLSTNLQ 433 (1116) T ss_dssp HHHTHHHHHH-CSCHHHHHHHHHHHHHHHHHCHH-----HHHHT-HHHHHHHHHHHHTCSSHHHHHHHHHHHHHHHHHHT T ss_pred HHHHHHHHhh-CCCHHHHHHHHHHHHHHHhCCHH-----HHHHh-HHHHHHHHHHHccCCCHHHHHHHHHHHHHHHHhcH Confidence 4555555665 35677788888888888764321 11111 13566777777777788899999999999886521 Q NP_000290.2 628 -LHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQ-LAKQYFSSSMLNNIINLCRS-SASPKAAEAA 704 (747) Q Consensus 628 -~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e-~~~~Lve~giL~~Ll~LL~s-~~d~eVr~aA 704 (747) ........+++.+...+... .+..++..++.+|..++...+. ...... ..+++.+...+.+ . ++.++..+ T Consensus 434 ~~~~~~~~~~~~~l~~~l~~~-----~~~~v~~~a~~~l~~l~~~~~~~~~~~~~-~~~~~~l~~~l~~~~-~~~~~~~~ 506 (1116) T 5VE8_B 434 DEVARYHEQYLPLVIDIIDSA-----KHVVIYKYATLALDGLLEFIAHNDIIKYL-DPLMNKLFQMLETQQ-SPKLRAAI 506 (1116) T ss_dssp HHHHTTHHHHHHHHHHHHHTC-----CSHHHHHHHHHHHHHHHHTSCHHHHHHHH-HHHHHHHHHHHHHCC-CHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHhccC-----CCHHHHHHHHHHHHHHHhhcCHhhHHHHH-HHHHHHHHHHHhcCC-CHHHHHHH Confidence 11111123555666665541 2567788888888888764222 111111 2356666666665 3 56777778 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.++..++.. T Consensus 507 ~~~l~~l~~~ 516 (1116) T 5VE8_B 507 VSAIGSCAFA 516 (1116) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 8888777653 No 474 >4ZV6_A AlphaRep-7, Octarellin V.1; synthetic gene, artificial protein, Rossmann-like; 2.22A {synthetic construct} Probab=71.73 E-value=0.3 Score=43.65 Aligned_cols=29 Identities=17% Similarity=0.240 Sum_probs=18.6 Template_Neff=12.500 Q NP_000290.2 685 LNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 685 L~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++.+...+.+. ++.++..++.++..+... T Consensus 140 ~~~l~~~l~~~-~~~~r~~a~~~l~~~~~~ 168 (294) T 4ZV6_A 140 VEPLIKALKDE-DPYVRMAAAYALGKIGDE 168 (294) T ss_pred HHHHHHHhCCC-CHHHHHHHHHHHhhhCCH Confidence 34455555554 667788888888776543 No 475 >6BZX_A alpha-Rep, Octarellin V.1; protein design, artificial protein, DE; 3.107A {synthetic construct} Probab=71.39 E-value=0.31 Score=43.56 Aligned_cols=29 Identities=17% Similarity=0.240 Sum_probs=18.5 Template_Neff=12.500 Q NP_000290.2 685 LNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 685 L~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++.+...+.+. ++.++..++.++..+... T Consensus 140 ~~~l~~~l~~~-~~~~r~~a~~~l~~~~~~ 168 (294) T 6BZX_A 140 VEPLIKALKDE-DPYVRMAAAYALGKIGDE 168 (294) T ss_dssp HHHHHHHTTCS-SHHHHHHHHHHHHHHTCG T ss_pred HHHHHHHhcCC-CHHHHHHHHHHHHHHcch Confidence 34455555554 667788888887776543 No 476 >5IFE_C Splicing factor 3B subunit 5; pre-mRNA splicing, U2 snRNP, essential; 3.1A {Homo sapiens} Probab=70.42 E-value=0.38 Score=55.84 Aligned_cols=154 Identities=9% Similarity=0.047 Sum_probs=91.7 Template_Neff=9.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) +++.|...+.+..++.++..++.+|..++..... .... .-..+++.|...+.+.+..++..++.+|..++... T Consensus 644 ll~~L~~~l~s~~~~~~r~~al~~L~~l~~~~~~-----~~~~-~l~~ll~~L~~~L~d~~~~VR~~a~~~L~~l~~~~~ 717 (1304) T 5IFE_C 644 LLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGC-----AILP-HLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAAT 717 (1304) T ss_pred HHHHHHHHHcCCCCHHHHHHHHHHHHHHHHHhhh-----hchh-hHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhCC Confidence 4455555555222367788888888888753221 0111 11345666777777777889999999999988652 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. ...+ ..+++.|+..+.+ ....++..++.+|..++..............++..|...+.+. +..++..++ T Consensus 718 ~~~~~~~-~~ll~~Ll~~l~~------~~~~v~~~~l~aL~~l~~~~~~~~~~~~~~~ll~~L~~~l~~~-~~~vr~~al 789 (1304) T 5IFE_C 718 PYGIESF-DSVLKPLWKGIRQ------HRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSP-DEEMKKIVL 789 (1304) T ss_pred HHHHHHH-HHHHHHHHHHHhc------CCHHHHHHHHHHHHHHHHhcCHHHhhhHHHHHHHHHHHHhCCC-CHHHHHHHH Confidence 11 1111 2345666666654 2456677788888877653221111111124566666777655 677888888 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .+|..++... T Consensus 790 ~~L~~l~~~~ 799 (1304) T 5IFE_C 790 KVVKQCCGTD 799 (1304) T ss_pred HHHHHHHhcc Confidence 8888877543 No 477 >6AHD_1 Pre-mRNA-processing-splicing factor 8, Thioredoxin-like protein; Spliceosome, SPLICING; HET: IHP, GTP; 3.8A {Homo sapiens} Probab=70.42 E-value=0.38 Score=55.84 Aligned_cols=154 Identities=9% Similarity=0.047 Sum_probs=91.7 Template_Neff=9.800 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHP- 626 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~- 626 (747) +++.|...+.+..++.++..++.+|..++..... .... .-..+++.|...+.+.+..++..++.+|..++... T Consensus 644 ll~~L~~~l~s~~~~~~r~~al~~L~~l~~~~~~-----~~~~-~l~~ll~~L~~~L~d~~~~VR~~a~~~L~~l~~~~~ 717 (1304) T 6AHD_1 644 LLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGC-----AILP-HLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAAT 717 (1304) T ss_pred HHHHHHHHHcCCCCHHHHHHHHHHHHHHHHHhhh-----hchh-hHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhCC Confidence 4455555555222367788888888888753221 0111 11345666777777777889999999999988652 Q NP_000290.2 627 LL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAAR 705 (747) Q Consensus 627 e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL 705 (747) .. ...+ ..+++.|+..+.+ ....++..++.+|..++..............++..|...+.+. +..++..++ T Consensus 718 ~~~~~~~-~~ll~~Ll~~l~~------~~~~v~~~~l~aL~~l~~~~~~~~~~~~~~~ll~~L~~~l~~~-~~~vr~~al 789 (1304) T 6AHD_1 718 PYGIESF-DSVLKPLWKGIRQ------HRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSP-DEEMKKIVL 789 (1304) T ss_pred HHHHHHH-HHHHHHHHHHHhc------CCHHHHHHHHHHHHHHHHhcCHHHhhhHHHHHHHHHHHHhCCC-CHHHHHHHH Confidence 11 1111 2345666666654 2456677788888877653221111111124566666777655 677888888 Q NP_000290.2 706 LLLSDMWSSK 715 (747) Q Consensus 706 ~aLsnL~~~~ 715 (747) .+|..++... T Consensus 790 ~~L~~l~~~~ 799 (1304) T 6AHD_1 790 KVVKQCCGTD 799 (1304) T ss_pred HHHHHHHhcc Confidence 8888877543 No 478 >2QK2_A LP04448p; Mini spindles, Msps, XMAP215, Dis1; 2.1A {Drosophila melanogaster} Probab=70.35 E-value=0.34 Score=41.59 Aligned_cols=113 Identities=7% Similarity=-0.008 Sum_probs=66.2 Template_Neff=12.700 Q NP_000290.2 243 SGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLL-RSPNQNVQQAAAGALRNLVFRSTTN 321 (747) Q Consensus 243 ~~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL-~s~d~eVr~~AL~aLs~La~~~~~~ 321 (747) ...+++.+...+.+.++.++..++..+..+....+....... ..+++.+...+ .+.++.++..++.++..+....... T Consensus 13 ~~~l~~~l~~~l~~~~~~~r~~a~~~l~~~~~~~~~~~~~~~-~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~~~~~~~ 91 (242) T 2QK2_A 13 LSKMPKDFYDKLEEKKWTLRKESLEVLEKLLTDHPKLENGEY-GALVSALKKVITKDSNVVLVAMAGKCLALLAKGLAKR 91 (242) T ss_dssp GGGSCTTHHHHHTCSSHHHHHHHHHHHHHHHHHCSSBCCCCC-HHHHHHHHHHHHHCSCHHHHHHHHHHHHHHHHHHGGG T ss_pred hhhCCHHHHHHHhccchHHHHHHHHHHHHHHhhCcccccchH-HHHHHHHHHHHccCcHHHHHHHHHHHHHHHHHHhhHh Confidence 344555666667777788888999988888764332111111 23566666667 6667788888888888877543322 Q NP_000290.2 322 KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLS 358 (747) Q Consensus 322 ~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLa 358 (747) .... ...+++.+...+. +.+..++..+..++..+. T Consensus 92 ~~~~-~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~~~ 126 (242) T 2QK2_A 92 FSNY-ASACVPSLLEKFK-EKKPNVVTALREAIDAIY 126 (242) T ss_dssp GHHH-HHHHHHHHHHGGG-CCCHHHHHHHHHHHHHHH T ss_pred HHHH-HHhHHHHHHHHHh-cCCHHHHHHHHHHHHHHH Confidence 1111 1234555555554 334455555555555544 No 479 >6MZG_E Tubulin alpha-1A chain, Tubulin beta; Microtubule, Tubulin, Tubulin polymerization, Heat; HET: GTP, GDP; 3.208A {Sus scrofa} Probab=70.02 E-value=0.35 Score=47.53 Aligned_cols=71 Identities=15% Similarity=0.238 Sum_probs=44.3 Template_Neff=12.700 Q NP_000290.2 549 IRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQ---LIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 549 I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~---~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) ++.++..+. +.++.++..++.+|..++..... . .. .. ....+++.+..++.+.++.++..++.+|..+... T Consensus 138 ~~~l~~~l~-~~~~~vr~~~~~~l~~l~~~~~~---~-~~~~~~~-~~~~i~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 211 (554) T 6MZG_E 138 VNLMLPSLS-NKLPRLVSSCVKCLATIIEEFGF---I-NVSDINI-LLSEILEPLPKLSSHADRNVRSETMNLILQIYKW 211 (554) T ss_dssp HHHHSGGGG-CSCHHHHHHHHHHHHHHHHHTCS---C-SCSCHHH-HHHHHHSSHHHHTTCSSHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHhc-CCCHHHHHHHHHHHHHHHHHhCC---C-ccccccc-cHHHHHHHHHHHhhcCCHHHHHHHHHHHHHHHHH Confidence 444555555 35667777888888877653221 0 00 00 1235667777777777788888888888877654 No 480 >6QH7_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: SEP; 3.4A {Rattus norvegicus} Probab=69.91 E-value=0.36 Score=48.86 Aligned_cols=100 Identities=18% Similarity=0.054 Sum_probs=56.7 Template_Neff=12.200 Q NP_000290.2 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETR 326 (747) Q Consensus 247 L~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ll 326 (747) ++.+...+.+.++.++..++.++..+........ ..++..+...+.+.++.++..++.++..+.... . T Consensus 76 ~~~l~~~l~~~~~~~r~~a~~~l~~~~~~~~~~~-----~~~~~~l~~~l~~~~~~vr~~al~~l~~~~~~~-------~ 143 (621) T 6QH7_A 76 HMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELI-----RLINNAIKNDLASRNPTFMGLALHCIANVGSRE-------M 143 (621) T ss_dssp HHHHHHHTTCSSHHHHHHHHHHHHHSCCCCHHHH-----HHHHHHHHHHHHSCCHHHHHHHHHHHHHHCCHH-------H T ss_pred HHHHHHHHcCCCccHHHHHHHHHHHHcCCCHHHH-----HHHHHHHHHHHhcCCHHHHHHHHHHHHhhCCHH-------H Confidence 3344455555666677777777776654322111 123444555555666777777777777665321 0 Q NP_000290.2 327 RQNGIREAVSLL--RRTGNAEIQKQLTGLLWNLSS 359 (747) Q Consensus 327 ~~~IL~~Ll~lL--~ss~d~eVr~~AL~aLsnLas 359 (747) ...++..+...+ . +.++.++..++.++..+.. T Consensus 144 ~~~l~~~l~~~l~~~-~~~~~vr~~a~~~L~~~~~ 177 (621) T 6QH7_A 144 AEAFAGEIPKILVAG-DTMDSVKQSAALCLLRLYR 177 (621) T ss_dssp HHHHTTHHHHHHTTS-CCCHHHHHHHHHHHHHHHH T ss_pred HHHHHhhHHHHHHcC-CCCHHHHHHHHHHHHHHHH Confidence 113444455555 4 4566777788888777765 No 481 >1UKL_A Importin beta-1 subunit/Sterol regulatory element; Transcription factor, Nuclear transport factor; HET: MSE; 3.0A {Mus musculus} SCOP: a.118.1.1 Probab=69.90 E-value=0.35 Score=50.26 Aligned_cols=154 Identities=11% Similarity=0.064 Sum_probs=87.3 Template_Neff=13.100 Q NP_000290.2 548 AIRTYLNLMGKSKK--DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGN--SDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d--~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d--~eVr~~AL~aLsnLa 623 (747) .++.+...+. +.+ +.++..++.+|..+...... . .... ....+++.+...+.+.+ +.++..++.++..+. T Consensus 129 l~~~l~~~l~-~~~~~~~~~~~al~~l~~l~~~~~~---~-~~~~-~~~~l~~~l~~~l~~~~~~~~vr~~a~~~l~~~~ 202 (876) T 1UKL_A 129 LIPQLVANVT-NPNSTEHMKESTLEAIGYICQDIDP---E-QLQD-KSNEILTAIIQGMRKEEPSNNVKLAATNALLNSL 202 (876) T ss_dssp SHHHHHHHHH-STTCCHHHHHHHHHHHHHHHHHSCS---T-TTSS-SCHHHHHHHHHTTSTTCSCHHHHHHHHHHHHHHG T ss_pred HHHHHHHHhh-CCCCCHHHHHHHHHHHHHHhccCCH---H-HHHH-HHHHHHHHHHHHHhCCCCCHHHHHHHHHHHHHHH Confidence 3455555565 233 56777788888777653221 0 0001 12346666777776655 778888888888876 Q NP_000290.2 624 RH-PLL-H-RVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKA 700 (747) Q Consensus 624 ~~-~e~-~-~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eV 700 (747) .. ... . ......++..+..++.+ .++.++..++.+|..+....+..........+++.+...+.+. ++.+ T Consensus 203 ~~~~~~~~~~~~~~~~~~~l~~~~~~------~~~~~r~~a~~~l~~l~~~~~~~~~~~~~~~l~~~l~~~l~~~-~~~v 275 (876) T 1UKL_A 203 EFTKANFDKESERHFIMQVVCEATQC------PDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSD-IDEV 275 (876) T ss_dssp GGCHHHHHSHHHHHHHHHHHHHHTTS------SCHHHHHHHHHHHHHHHTTCGGGGHHHCCCCCHHHHHHHHHCS-CHHH T ss_pred HHhHHhcCCHHHHHHHHHHHHHHhCC------CCHHHHHHHHHHHHHHHHHHHHHhHHhchHHHHHHHHHHhhCC-CHHH Confidence 54 111 0 01112233334444443 3577888899999888765333222122223456666666655 6778 Q NP_000290.2 701 AEAARLLLSDMWSS 714 (747) Q Consensus 701 r~aAL~aLsnL~~~ 714 (747) +..++.++..+... T Consensus 276 ~~~a~~~l~~l~~~ 289 (876) T 1UKL_A 276 ALQGIEFWSNVCDE 289 (876) T ss_dssp HHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH Confidence 88888888777653 No 482 >6EMK_C Serine/threonine-protein kinase TOR2 (E.C.2.7.1.67,2.7.11.1), Target; target of rapamycin, torc2, FRB; 8.0A {Saccharomyces cerevisiae (strain ATCC 204508 / S288c)} Probab=69.88 E-value=0.38 Score=58.82 Aligned_cols=136 Identities=10% Similarity=0.088 Sum_probs=72.9 Template_Neff=11.300 Q NP_000290.2 562 DATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLL-HRVMGNQVFPEV 640 (747) Q Consensus 562 ~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~-~~ll~~giI~~L 640 (747) +.++..++.+|..++..... . .... -..+++.|...+.+....++..+..++..+...... ...+ ..+++.+ T Consensus 1016 ~~vr~~a~~~l~~l~~~~~~---~-~~~~--~~~ll~~l~~~l~~~~~~~~~~~~~~l~~l~~~~~~~~~~l-~~i~~~l 1088 (2474) T 6EMK_C 1016 IKLQITIISVIESISKALEG---E-FKRF--VPETLTFFLDILENDQSNKRIVPIRILKSLVTFGPNLEDYS-HLIMPIV 1088 (2474) T ss_dssp CCCCCCCSSCCCCCCSSCSC---C-SCCC--CCCCCTTHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCC-CCCTTHH T ss_pred hHHHHHHHHHHHHHHHHhhH---h-HHHH--HHHHHHHHHHHHhcCCCCCcchHHHHHHHHHHhhhhHHHHH-HHHHHHH Confidence 34555666666666543221 0 0111 134556666666655445555555565555533111 1111 2244555 Q NP_000290.2 641 TRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 641 l~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) +..+.. .++.++..++.+|..++..... .. ....++..+...+.+. ++.++..++.+|..++.. T Consensus 1089 ~~~l~~------~~~~vr~~a~~~l~~l~~~~~~--~~-~~~~i~~~l~~~l~~~-~~~vr~~a~~~l~~l~~~ 1152 (2474) T 6EMK_C 1089 VRMTEY------SAGSLKKISIITLGRLAKNINL--SE-MSSRIVQALVRILNNG-DRELTKATMNTLSLLLLQ 1152 (2474) T ss_dssp HHCCCC------CCCCCTTTTTCCCCCCCCCCCC--CC-CCCCCCCCCCSCCCCC-CCCSSHHHHTTTCCGGGC T ss_pred HHHhcC------CCccHHHHHHHHHHHHHHhCCh--HH-HHHHHHHHHHHHHhcC-CHHHHHHHHHHHHHHHHH Confidence 555554 2567888888888888754221 11 1123566666666654 667788888888777653 No 483 >4XL5_C Green fluorescent protein, bGFP-A; AlphaRep Scaffold, Complex, EGFP, PROTEIN; HET: CRO; 2.0A {Aequorea victoria} Probab=69.87 E-value=0.36 Score=42.43 Aligned_cols=49 Identities=10% Similarity=0.082 Sum_probs=29.3 Template_Neff=12.400 Q NP_000290.2 654 SEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 654 d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ++.++..++.++..+.. ...++.+..++.+. ++.++..++.++..+... T Consensus 120 ~~~~~~~a~~~l~~~~~-----------~~~~~~l~~~l~~~-~~~vr~~a~~~l~~~~~~ 168 (263) T 4XL5_C 120 DPWVRLTAARALGEIGD-----------ERAVEPLIKALKDE-DPWVRLTAARALGQIGDE 168 (263) T ss_dssp SHHHHHHHHHHHHHHCC-----------GGGHHHHHHHTTCS-SHHHHHHHHHHHHHHCCG T ss_pred CHHHHHHHHHHHHHHCC-----------hhhHHHHHHHhhCC-CHHHHHHHHHHHHhhCCH Confidence 34455555555554432 12345555666655 678888888888877653 No 484 >4D4Z_A DEOXYHYPUSINE HYDROXYLASE (E.C.1.14.99.29); OXIDOREDUCTASE, EIF-5A, HYPUSINE; HET: B3P, GOL; 1.7A {HOMO SAPIENS} Probab=69.81 E-value=0.36 Score=42.88 Aligned_cols=127 Identities=10% Similarity=0.093 Sum_probs=78.7 Template_Neff=12.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDA--TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 547 G~I~~LL~LL~ss~d~e--Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++.|...+. +.+.. ++..++.+|..+.. ...++.+...+.+.++.++..++.+|..+.. T Consensus 161 ~~~~~l~~~l~-~~~~~~~~r~~a~~~l~~~~~----------------~~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~ 223 (294) T 4D4Z_A 161 RDVGRLREALL-DESRPLFERYRAMFALRNAGG----------------EEAALALAEGLHCGSALFRHEVGYVLGQLQH 223 (294) T ss_dssp CCHHHHHHHHH-CTTSCHHHHHHHHHHHHHHCH----------------HHHHHHHHHGGGSSCHHHHHHHHHHHHHHCC T ss_pred HHHHHHHHHHH-hCCCCHHHHHHHHHHHHHcCC----------------HHHHHHHHHHhcCCCHHHHHHHHHHHHhcCC Confidence 34566667776 34433 66677777665532 1234455666667777888888888877653 Q NP_000290.2 625 HPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 625 ~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . ..++.+...+.+. ..++.++..++.+|+.+... ..++.|..++.+. ++.++..+ T Consensus 224 ~---------~~~~~l~~~l~~~----~~~~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~vr~~a 278 (294) T 4D4Z_A 224 E---------AAVPQLAAALARC----TENPMVRHECAEALGAIARP-----------ACLAALQAHADDP-ERVVRESC 278 (294) T ss_dssp G---------GGHHHHHHHHHCT----TSCHHHHHHHHHHHHHHCCH-----------HHHHHHHHHTTCS-SHHHHHHH T ss_pred h---------hHHHHHHHHHHhC----CCCHHHHHHHHHHHHHhccH-----------HHHHHHHHHhcCC-ChHHHHHH Confidence 2 2344455555520 02567888888888876531 2455666667655 67788888 Q NP_000290.2 705 RLLLSDMWSSK 715 (747) Q Consensus 705 L~aLsnL~~~~ 715 (747) +.+|..+.... T Consensus 279 ~~~l~~~~~~~ 289 (294) T 4D4Z_A 279 EVALDMYEHET 289 (294) T ss_dssp HHHHHHHHHC- T ss_pred HHHHHHHHhhc Confidence 88888776443 No 485 >4D50_A DEOXYHYPUSINE HYDROXYLASE (E.C.1.14.99.29); OXIDOREDUCTASE; HET: GAI; 1.7A {HOMO SAPIENS} Probab=69.81 E-value=0.36 Score=42.88 Aligned_cols=127 Identities=10% Similarity=0.093 Sum_probs=79.0 Template_Neff=12.700 Q NP_000290.2 547 DAIRTYLNLMGKSKKDA--TLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 624 (747) Q Consensus 547 G~I~~LL~LL~ss~d~e--Vr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~ 624 (747) ..++.|...+. +.+.. ++..++.+|..+.. ...++.+...+.+.++.++..++.+|..+.. T Consensus 161 ~~~~~l~~~l~-~~~~~~~~r~~a~~~l~~~~~----------------~~~~~~l~~~l~~~~~~~r~~a~~~l~~~~~ 223 (294) T 4D50_A 161 RDVGRLREALL-DESRPLFERYRAMFALRNAGG----------------EEAALALAEGLHCGSALFRHEVGYVLGQLQH 223 (294) T ss_dssp CCHHHHHHHHH-CTTSCHHHHHHHHHHHHHHCS----------------HHHHHHHHHGGGSSCHHHHHHHHHHHHHHCC T ss_pred HHHHHHHHHHH-hCCCCHHHHHHHHHHHHHcCC----------------HHHHHHHHHHhcCCCHHHHHHHHHHHHhcCC Confidence 34566667776 34433 66677777665532 1234455666667777888888888877653 Q NP_000290.2 625 HPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 625 ~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) . ..++.+...+.+. ..++.++..++.+|+.+... ..++.|..++.+. ++.++..+ T Consensus 224 ~---------~~~~~l~~~l~~~----~~~~~vr~~a~~~l~~~~~~-----------~~~~~l~~~l~~~-~~~vr~~a 278 (294) T 4D50_A 224 E---------AAVPQLAAALARC----TENPMVRHECAEALGAIARP-----------ACLAALQAHADDP-ERVVRESC 278 (294) T ss_dssp G---------GGHHHHHHHHHCT----TSCHHHHHHHHHHHHHHCCH-----------HHHHHHHHTTTCS-CHHHHHHH T ss_pred h---------hHHHHHHHHHHhC----CCCHHHHHHHHHHHHHhccH-----------HHHHHHHHHhcCC-ChHHHHHH Confidence 2 2344455555520 02567888888888876531 2455666667655 67788888 Q NP_000290.2 705 RLLLSDMWSSK 715 (747) Q Consensus 705 L~aLsnL~~~~ 715 (747) +.+|..+.... T Consensus 279 ~~~l~~~~~~~ 289 (294) T 4D50_A 279 EVALDMYEHET 289 (294) T ss_dssp HHHHHHHHHHH T ss_pred HHHHHHHHhhc Confidence 88888776443 No 486 >6QH5_A AP-2 complex subunit alpha, AP-2; ENDOCYTOSIS, PHOSPHORYLATION, CELL MEMBRANE, PROTEIN; HET: IHP; 2.56A {Rattus norvegicus} Probab=69.69 E-value=0.37 Score=48.79 Aligned_cols=67 Identities=12% Similarity=0.101 Sum_probs=37.3 Template_Neff=12.200 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQ-SGNSDVVRSGASLLSNMS 623 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~-s~d~eVr~~AL~aLsnLa 623 (747) .++.+..++. +.++.++..++.+|..+...... ... -...++.+...+. +.++.++..++.+|..+. T Consensus 330 ~~~~l~~~l~-~~~~~vr~~a~~~L~~l~~~~~~------~~~--~~~~~~~l~~~l~~~~~~~vr~~a~~~l~~l~ 397 (621) T 6QH5_A 330 ACNQLGQFLQ-HRETNLRYLALESMCTLASSEFS------HEA--VKTHIETVINALKTERDVSVRQRAVDLLYAMC 397 (621) T ss_pred HHHHHHHHHh-CCCHHHHHHHHHHHHHHHhcCCC------hhH--HHHHHHHHHHHHhcCCCHHHHHHHHHHHHHhc Confidence 4555666665 35666777777777777653110 111 1224445555555 555666666666666653 No 487 >4XL5_C Green fluorescent protein, bGFP-A; AlphaRep Scaffold, Complex, EGFP, PROTEIN; HET: CRO; 2.0A {Aequorea victoria} Probab=69.51 E-value=0.37 Score=42.33 Aligned_cols=88 Identities=10% Similarity=0.162 Sum_probs=47.9 Template_Neff=12.400 Q NP_000290.2 600 IARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQY 679 (747) Q Consensus 600 Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~L 679 (747) +..++.+.++.++..++.++..+.. ...++.+...+.+ .++.++..++.+|..+.. T Consensus 143 l~~~l~~~~~~vr~~a~~~l~~~~~---------~~~~~~l~~~l~~------~~~~~r~~a~~~l~~~~~--------- 198 (263) T 4XL5_C 143 LIKALKDEDPWVRLTAARALGQIGD---------ERAVEPLIKALKD------EDASVRKAAAVALGQIGD--------- 198 (263) T ss_dssp HHHHTTCSSHHHHHHHHHHHHHHCC---------GGGHHHHHHHTTC------SSHHHHHHHHHHHHHHCC--------- T ss_pred HHHHhhCCCHHHHHHHHHHHHhhCC---------HHHHHHHHHHhcC------CCHHHHHHHHHHHHHhCC--------- Confidence 3344444444555555555444432 1223344444444 245566667666666542 Q NP_000290.2 680 FSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSS 714 (747) Q Consensus 680 ve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~ 714 (747) ...++.+..++.+. +..++..++.++..+... T Consensus 199 --~~~~~~l~~~l~~~-~~~~~~~a~~~l~~~~~~ 230 (263) T 4XL5_C 199 --ERAVEPLIKALKDE-DEYVRQRAASALGKIGGE 230 (263) T ss_dssp --GGGHHHHHHHTTCS-SHHHHHHHHHHHHHHCHH T ss_pred --hhhHHHHHHHhcCC-CHHHHHHHHHHHHhhCcH Confidence 12345566666655 677888888888887753 No 488 >6LTJ_L Histone H3.2, Histone H4, Histone; Chromatin remodeler, Complex, GENE REGULATION; 3.7A {Xenopus laevis} Probab=69.20 E-value=0.52 Score=55.12 Aligned_cols=106 Identities=11% Similarity=0.124 Sum_probs=60.8 Template_Neff=5.100 Q NP_000290.2 609 SDVVRSGASLLSNMSRHPLL---HRVMGNQVFPEVTRLLTSHTGNTSNSE----------DILSSACYTVRNLMASQPQL 675 (747) Q Consensus 609 ~eVr~~AL~aLsnLa~~~e~---~~ll~~giI~~Ll~LL~s~s~~~~~d~----------eVr~~Al~aLsnLa~~s~e~ 675 (747) ..+++.++.+|.||+...+. ...+...++..|+.++...... ..++ ..+..|+.+|+.|+.. +.+ T Consensus 1064 ~~LRenaLviLaNIAg~LdLs~~~e~I~~~ild~LLhwlv~~sa~-a~Dp~~~~~~~~~lSp~~lALEaLsKLsv~-d~N 1141 (1295) T 6LTJ_L 1064 EMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAE-AQDPFSTLGPNAVLSPQRLVLETLSKLSIQ-DNN 1141 (1295) T ss_dssp HHHHHHHHHHHHHHGGGCCCSSSCHHHHHHHHHHHHHHHHCCSSS-SSSCCTTSCTTCCCCHHHHHHHHHHHHHTS-HHH T ss_pred HHHHHHHHHHHHHHHcccCCCCCChHhHHHHHHHHHHHHcCcChh-cCChhhccCCCCCCCHHHHHHHHHHHHhCC-Cch Confidence 35667788889998876221 1111112455555544321000 0011 1234589999999874 555 Q NP_000290.2 676 AKQYFSSS-------MLNNIINLCRSSASPKAAEAARLLLSDMWSSKE 716 (747) Q Consensus 676 ~~~Lve~g-------iL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~~ 716 (747) ...++... ++..|+.+|....+..+++.++.+|.+|+...+ T Consensus 1142 ~dlLlat~p~srle~Ll~~LV~lL~~~ed~~lrE~AL~lL~~Ls~~~~ 1189 (1295) T 6LTJ_L 1142 VDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDS 1189 (1295) T ss_dssp HHHHHTSSCHHHHHHHHHHHHHHHHHCSSHHHHHHHHHHHHHHHHHCH T ss_pred HHHHHhCCCHHHHHHHHHHHHHHhcCCCCHHHHHHHHHHHHHHHcCCH Confidence 55555433 566667777644245678899999999987543 No 489 >5WLC_LM rpS18_uS13, rpS4_eS4, rpS5_uS7, rpS6_eS6, rpS7_eS7; Ribosome assembly, RIBOSOME; 3.8A {Saccharomyces cerevisiae BY4741} Probab=69.09 E-value=0.44 Score=57.42 Aligned_cols=153 Identities=6% Similarity=-0.058 Sum_probs=85.4 Template_Neff=9.300 Q NP_000290.2 548 AIRTYLNLMGKS-----KKDATLEACAGALQNLTASKGLMSSGMSQL-IGLKEKGLPQIARLLQSGNSDVVRSGASLLSN 621 (747) Q Consensus 548 ~I~~LL~LL~ss-----~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~-llie~giI~~Ll~LL~s~d~eVr~~AL~aLsn 621 (747) +++.++..+... .+..++..++.+|..++..... ..... .. -..+++.|...+......++..++.++.. T Consensus 1597 ll~~l~~~L~~~~~~~~~~~~v~~~al~~L~~l~~~~~~---~~~~~~~~-~~~il~~L~~~L~~~~~~v~~~al~~L~~ 1672 (1769) T 5WLC_LM 1597 LLEPVDMLLKRFISKDMENVNLRRLVINSLTSSLKFDRD---EYWKSTSR-FELISVSLVNQLSNIENSIGKYLVKAIGA 1672 (1769) T ss_pred HHHHHHHHHHHhcCCchhcHHHHHHHHHHHHHHHhhCCc---ccccCHhH-HHHHHHHHHHHHHccchHHHHHHHHHHHH Confidence 455555555421 1356677888888887764221 00000 11 13456666666666556677778888888 Q NP_000290.2 622 MSRH-PLLHRVMGNQVFPEVTRLLTSHTGNTSN-SEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPK 699 (747) Q Consensus 622 La~~-~e~~~ll~~giI~~Ll~LL~s~s~~~~~-d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~e 699 (747) ++.. ....... ..+.+.++..+.+ . +..++..++.++..+..........+. ..+++.+.+.+.+. ++. T Consensus 1673 L~~~~~~~~~~~-~~l~~~ll~~l~~------~~~~~vR~~al~~L~~l~~~~g~~~~~~l-~~il~~L~e~Led~-~~~ 1743 (1769) T 5WLC_LM 1673 LASNNSGVDEHN-QILNKLIVEHMKA------SCSSNEKLWAIRAMKLIYSKIGESWLVLL-PQLVPVIAELLEDD-DEE 1743 (1769) T ss_pred HHHhccCChHHH-HHHHHHHHHHhcC------CCCHHHHHHHHHHHHHHHHHHChhHHHhH-hHHHHHHHHHccCC-CHH Confidence 7653 1111111 1133344444433 2 567788888898888765332211111 24567777777765 677 Q NP_000290.2 700 AAEAA-RLLLSDMWS 713 (747) Q Consensus 700 Vr~aA-L~aLsnL~~ 713 (747) ++..+ ..++..+.. T Consensus 1744 Vr~~a~~~~l~~L~~ 1758 (1769) T 5WLC_LM 1744 IEREVRTGLVKVVEN 1758 (1769) T ss_pred HHHHHHHHHHHHHHH Confidence 88888 777776654 No 490 >5YVI_A Transportin-1, RNA-binding protein FUS; Importin family, PROTEIN TRANSPORT, PROTEIN; 2.9A {Homo sapiens} Probab=69.07 E-value=0.37 Score=49.71 Aligned_cols=155 Identities=9% Similarity=0.106 Sum_probs=91.1 Template_Neff=13.300 Q NP_000290.2 548 AIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIG--LKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 625 (747) Q Consensus 548 ~I~~LL~LL~ss~d~eVr~~AL~aL~nLs~~s~~~s~~~~~~ll--ie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~ 625 (747) .++.+...+. +.++.++..++.+|..++..... ......+ .-..+++.+...+.+.++.++..++.+|..++.. T Consensus 131 ~~~~l~~~l~-~~~~~~~~~~l~~l~~l~~~~~~---~~~~~~~~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~ 206 (868) T 5YVI_A 131 LLPKLCSLLD-SEDYNTCEGAFGALQKICEDSAE---ILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIIS 206 (868) T ss_dssp HHHHHHHHHT-CSSHHHHHHHHHHHHHHHHHHTT---CSCC--CCSTHHHHHHHHGGGGGCSSHHHHHHHHHHHHTTTTT T ss_pred HHHHHHHHhc-CCChHHHHHHHHHHHHHHHHHhh---hcchhhccHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHh Confidence 4555666665 35667777888888887754211 0000000 0134566677777777788888999999888765 Q NP_000290.2 626 PLL-HRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAA 704 (747) Q Consensus 626 ~e~-~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aA 704 (747) ... .......+++.+...+.+ .+..++..++.+|..++........... ..+++.+...+.+. ++.++..+ T Consensus 207 ~~~~~~~~~~~~~~~l~~~l~~------~~~~~~~~~~~~l~~l~~~~~~~~~~~~-~~~~~~l~~~l~~~-~~~v~~~~ 278 (868) T 5YVI_A 207 RTQALMLHIDSFIENLFALAGD------EEPEVRKNVCRALVMLLEVRMDRLLPHM-HNIVEYMLQRTQDQ-DENVALEA 278 (868) T ss_dssp TCHHHHTTHHHHHHHHHHTTTC------SSHHHHHHHHHHHHHHHHHCHHHHGGGH-HHHHHHHHHHHTCS-SHHHHHHH T ss_pred chHHHHHhHHHHHHHHHHHcCC------CCHHHHHHHHHHHHHHHHHcHHHHHHhH-HHHHHHHHHHccCC-CHHHHHHH Confidence 211 111112345555555544 2567788888888888764322111111 23456666666655 67788888 Q NP_000290.2 705 RLLLSDMWSS 714 (747) Q Consensus 705 L~aLsnL~~~ 714 (747) +.++..++.. T Consensus 279 ~~~l~~l~~~ 288 (868) T 5YVI_A 279 CEFWLTLAEQ 288 (868) T ss_dssp HHHHHHHHHS T ss_pred HHHHHHHhcC Confidence 8888887764 No 491 >3VWA_A Cytoplasmic export protein 1; tRNA, nuclear export, HEAT repeat; 2.2A {Saccharomyces cerevisiae} Probab=68.93 E-value=0.42 Score=49.31 Aligned_cols=111 Identities=9% Similarity=0.051 Sum_probs=80.6 Template_Neff=10.600 Q NP_000290.2 594 EKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP 673 (747) Q Consensus 594 ~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~ 673 (747) ..+++.+..++.+.++.++..++..|..++.... .......+++.+...+.+ .+..++..++.+|..++...+ T Consensus 340 ~~~~~~l~~ll~~~~~~vR~~~~~~l~~~~~~~~-~~~~~~~~~~~l~~~l~d------~~~~vr~~a~~~l~~l~~~~~ 412 (560) T 3VWA_A 340 VGFNDLITQSFKLPDRQVRFLLLIYLPKLIGPLS-KSEISSRIYPHFIQGLTD------SDATLRLQTLKTIPCIVSCLT 412 (560) T ss_dssp TTHHHHHHHHHHCCCHHHHHHHHHHHHHHBTTBC-HHHCCCCCHHHHHHGGGC------SSHHHHHHHHHHHHHHGGGCC T ss_pred cchHHHHHHHcCCCCHHHHHHHHHhHHHHhccCC-HHHHHhchHHHHHHHhcC------CCHHHHHHHHHHHHHHHhhCC Confidence 4577888888888888999999999888876411 112234567777777766 367889999999999886432 Q NP_000290.2 674 QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 674 e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) .. .....+++.+..++.+. ++.++..++.+|..++... T Consensus 413 ~~---~~~~~ll~~l~~~l~d~-~~~vR~~a~~~l~~i~~~~ 450 (560) T 3VWA_A 413 ER---QLNNELLRFLAKTQVDS-DVEIRTWTVIIISKISTIL 450 (560) T ss_dssp HH---CCCCCCHHHHHHHTTCS-SHHHHHHHHHHHHHHGGGS T ss_pred HH---HHHHHHHHHHHHHcCCC-CHHHHHHHHHHHHHHHHHh Confidence 11 22345677888888766 7899999999999887544 No 492 >3VWA_B Cytoplasmic export protein 1; tRNA, nuclear export, HEAT repeat; HET: MSE; 2.2A {Saccharomyces cerevisiae} Probab=68.86 E-value=0.42 Score=49.21 Aligned_cols=111 Identities=9% Similarity=0.062 Sum_probs=80.6 Template_Neff=10.700 Q NP_000290.2 594 EKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQP 673 (747) Q Consensus 594 ~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa~~~e~~~ll~~giI~~Ll~LL~s~s~~~~~d~eVr~~Al~aLsnLa~~s~ 673 (747) ..+++.+..++.+.++.++..++..|..++.... .......+++.++..+.+ .++.++..++.+|..++...+ T Consensus 340 ~~~~~~l~~l~~~~~~~vr~~~~~~l~~~~~~~~-~~~~~~~~l~~l~~~l~d------~~~~vr~~a~~~l~~l~~~~~ 412 (560) T 3VWA_B 340 VGFNDLITQSFKLPDRQVRFLLLIYLPKLIGPLS-KSEISSRIYPHFIQGLTD------SDATLRLQTLKTIPCIVSCLT 412 (560) T ss_dssp TTHHHHHHHHHHCCCHHHHHHHHHHHHHHBTTBC-HHHCCCCCHHHHHHGGGC------SCHHHHHHHHHHHHHHGGGSC T ss_pred cchHHHHHHHcCCCcHHHHHHHHHhHHHHhhhCC-HHHHhhchHHHHHHHhcC------CCHHHHHHHHHHHHHHHhhCC Confidence 4577888888888888899999998888876421 112234567777777776 368899999999999886422 Q NP_000290.2 674 QLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSK 715 (747) Q Consensus 674 e~~~~Lve~giL~~Ll~LL~s~~d~eVr~aAL~aLsnL~~~~ 715 (747) . ......+++.|..++.+. ++.++..++.+|..++... T Consensus 413 ~---~~~~~~ll~~l~~~l~d~-~~~vR~~a~~~l~~i~~~~ 450 (560) T 3VWA_B 413 E---RQLNNELLRFLAKTQVDS-DVEIRTWTVIIISKISTIL 450 (560) T ss_dssp H---HCCCCCHHHHHHHHTTCS-SHHHHHHHHHHHHHHHTTS T ss_pred H---HHHHHHHHHHHHHHcCCC-CHHHHHHHHHHHHHHHHHh Confidence 1 122335678888888776 7899999999999887643 No 493 >3C5W_A PP2A A subunit, PP2A C; methylesterase, phosphatase, PP2A, HYDROLASE; 2.8A {Homo sapiens} Probab=68.82 E-value=0.38 Score=40.27 Aligned_cols=109 Identities=12% Similarity=0.007 Sum_probs=69.9 Template_Neff=13.200 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) ..++.+...+.+.++.++..++..+..+....... .....+++.+...+.+.++.++..++.++..+....... T Consensus 7 ~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~~~---~~~~~~~~~l~~~l~~~~~~vr~~~~~~l~~l~~~~~~~--- 80 (232) T 3C5W_A 7 YPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVE---RLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVE--- 80 (232) T ss_dssp SHHHHHHHHHTCSSHHHHHHHHTTHHHHHHHHCSS---HCCCCCHHHHHHHTTCSSHHHHHHHHTTHHHHHHHHCGG--- T ss_pred cHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHhChH---HHHHhHHHHHHHHHhCCCHHHHHHHHHHHHHHHHhhCHH--- Confidence 44556666777777888888888888876543211 112345666666677777788888888888776543211 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) .....+++.+...+. +.++.++..++.++..+... T Consensus 81 ~~~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~ 115 (232) T 3C5W_A 81 FFDEKLNSLCMAWLV-DHVYAIREAATSNLKKLVEK 115 (232) T ss_dssp GTTTTHHHHHHHHTT-CSSHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHh-CCCHHHHHHHHHHHHHHHHH Confidence 112235555666665 45677888888888877754 No 494 >4K92_B CLIP-associating protein 1; HEAT-Repeat TOG domain, Regulator of; HET: MSE; 2.005A {Homo sapiens} Probab=68.63 E-value=0.41 Score=43.13 Aligned_cols=109 Identities=12% Similarity=0.075 Sum_probs=66.8 Template_Neff=11.700 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.++..+.+.+..++..++.++..+..... ...+++.+...+.+.++.++..++.++..++........ T Consensus 129 ~~~l~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~-------~~~~~~~l~~~l~~~~~~~r~~~~~~l~~l~~~~~~~~~ 201 (273) T 4K92_B 129 EAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTH-------IPRLIPVITSNCTSKSVAVRRRCFEFLDLLLQEWQTHSL 201 (273) T ss_dssp HHHHHHHHTTTTCSSHHHHHHHHHHHHHHHHHCC-------CTTHHHHHHGGGGCSCHHHHHHHHHHHHHHHHHSCHHHH T ss_pred HHHHHHHHHHCccccHHHHHHHHHHHHHHHHhCC-------CchHHHHHHHHcCCCCHHHHHHHHHHHHHHHHHcCchhH Confidence 3445555555555566677777777777765321 123455555666666677888888888877754322100 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ......+++.+...+. +.+..++..++.++..+... T Consensus 202 ~~~~~~i~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~ 237 (273) T 4K92_B 202 ERHISVLAETIKKGIH-DADSEARIEARKCYWGFHSH 237 (273) T ss_dssp TTCHHHHHHHHHHHHT-CSSHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHH Confidence 1112345566666665 55778888888888888764 No 495 >6MQ7_B CLIP-associating protein 1; microtubule binding protein, STRUCTURAL PROTEIN; 1.78A {Homo sapiens} Probab=68.63 E-value=0.41 Score=43.13 Aligned_cols=109 Identities=12% Similarity=0.075 Sum_probs=66.8 Template_Neff=11.700 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) ..+++.++..+.+.+..++..++.++..+..... ...+++.+...+.+.++.++..++.++..++........ T Consensus 129 ~~~l~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~-------~~~~~~~l~~~l~~~~~~~r~~~~~~l~~l~~~~~~~~~ 201 (273) T 6MQ7_B 129 EAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTH-------IPRLIPVITSNCTSKSVAVRRRCFEFLDLLLQEWQTHSL 201 (273) T ss_dssp HHHHHHHHTTTTCSSHHHHHHHHHHHHHHHHHCC-------CGGGHHHHHHGGGCSCHHHHHHHHHHHHHHHHHSCGGGT T ss_pred HHHHHHHHHHCccccHHHHHHHHHHHHHHHHhCC-------CchHHHHHHHHcCCCCHHHHHHHHHHHHHHHHHcCchhH Confidence 3445555555555566677777777777765321 123455555666666677888888888877754322100 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ......+++.+...+. +.+..++..++.++..+... T Consensus 202 ~~~~~~i~~~l~~~l~-d~~~~vr~~a~~~l~~l~~~ 237 (273) T 6MQ7_B 202 ERHISVLAETIKKGIH-DADSEARIEARKCYWGFHSH 237 (273) T ss_dssp TTCHHHHHHHHHHHHT-CSSHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHH Confidence 1112345566666665 55778888888888888764 No 496 >4LAC_A Serine/threonine-protein phosphatase 2A activator (E.C.5.2.1.8); PP2A, PTPA, protein phosphatase, signaling; HET: AGS, MES; 2.82A {Homo sapiens} Probab=68.25 E-value=0.41 Score=41.40 Aligned_cols=109 Identities=7% Similarity=-0.006 Sum_probs=68.9 Template_Neff=12.800 Q NP_000290.2 245 LTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLE 324 (747) Q Consensus 245 ~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~~ 324 (747) .+++.+...+.+.++.++..++.++..+...... ......+++.+...+.+.+..++..++.++..+....... T Consensus 111 ~~~~~l~~~l~~~~~~vr~~a~~~l~~~~~~~~~---~~~~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~~--- 184 (258) T 4LAC_A 111 KLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGK---EWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQD--- 184 (258) T ss_pred HHHHHHHHHhcCCCHHHHHHHHHHHHHHHHcCCh---hHHHHhHHHHHHHHcCCCCHHHHHHHHHHHHHHHHcCCCC--- Confidence 3455556666666778888888888887654322 1112345566666666667778888888888776543221 Q NP_000290.2 325 TRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 325 ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) .....+++.+...+. +.++.++..++.++..+... T Consensus 185 ~~~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~ 219 (258) T 4LAC_A 185 ITTKHMLPTVLRMAG-DPVANVRFNVAKSLQKIGPI 219 (258) T ss_pred ccHhhHHHHHHHHhc-CCCHHHHHHHHHHHHHHHHH Confidence 112345566666665 55677888888888887653 No 497 >6MQ5_A CLIP-associating protein 1; Microtubule Plus End Binding, STRUCTURAL; HET: MSE; 2.146A {Homo sapiens} Probab=68.04 E-value=0.43 Score=42.33 Aligned_cols=108 Identities=10% Similarity=0.048 Sum_probs=65.9 Template_Neff=11.900 Q NP_000290.2 245 LTIPKAV-QYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKL 323 (747) Q Consensus 245 ~iL~~Ll-~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~~~ 323 (747) .++..+. .++.+.++.++..++.++..+........... ...+++.+...+.+.+..++..+..++..+...... T Consensus 49 ~~~~~l~~~~l~d~~~~vr~~a~~~l~~l~~~~~~~~~~~-~~~~~~~l~~~l~~~~~~vr~~a~~~l~~l~~~~~~--- 124 (257) T 6MQ5_A 49 KLVDGLATSWVNSSNYKVVLLGMDILSALVTRLQDRFKAQ-IGTVLPSLIDRLGDAKDSVREQDQTLLLKIMDQAAN--- 124 (257) T ss_dssp HHHHHCCCCCTTCSSHHHHHHHHHHHHHHHHHHGGGGHHH-HHHHHHHHHHHTTCSCHHHHHHHHHHHHHHHHHTSC--- T ss_pred HHHHHHHHHHhcCCcHHHHHHHHHHHHHHHHHhHHHHHHH-HHhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHccC--- Confidence 3444444 44556677788888888888876433221111 134566666666666677788888888777643211 Q NP_000290.2 324 ETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 324 ~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ...+++.+...+. ..++.++..++.++..+... T Consensus 125 ---~~~~~~~l~~~l~-~~~~~~r~~~l~~l~~l~~~ 157 (257) T 6MQ5_A 125 ---PQYVWDRMLGGFK-HKNFRTREGICLCLIATLNA 157 (257) T ss_dssp ---HHHHHHTTGGGGG-BSSHHHHHHHHHHHHHHHHH T ss_pred ---hHHHHHHHhhhcC-CCCHHHHHHHHHHHHHHHHH Confidence 1234555555564 45677888888888877653 No 498 >2QK1_A Protein STU2; stu2, Stu2p, XMAP215, Dis1, TOG; 1.7A {Saccharomyces cerevisiae} Probab=67.88 E-value=0.42 Score=40.93 Aligned_cols=116 Identities=3% Similarity=-0.016 Sum_probs=68.4 Template_Neff=12.900 Q NP_000290.2 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTN-- 321 (747) Q Consensus 244 ~~iL~~Ll~lL~ssd~eVr~sAL~aLsnLs~~~~~~~~~li~~~IL~~Ll~lL~s~d~eVr~~AL~aLs~La~~~~~~-- 321 (747) ..+++.+...+.+.+..++..++.++..+...............+++.+...+.+.++.++..++.++..++...... T Consensus 103 ~~~~~~l~~~l~~~~~~v~~~a~~~l~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~vr~~~~~~l~~~~~~~~~~~~ 182 (249) T 2QK1_A 103 SLVFTPLLDRTKEKKPSVIEAIRKALLTICKYYDPLASSGRNEDMLKDILEHMKHKTPQIRMECTQLFNASMKEEKDGYS 182 (249) T ss_dssp HHHHHHHHHGGGCCCHHHHHHHHHHHHHHHHHSCTTCTTCTTHHHHHHHHHHTTCSSHHHHHHHHHHHHHHHHHCCSCSH T ss_pred HHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHhChhcccCCHHHHHHHHHHHhCCCCHHHHHHHHHHHHHHHHhccccch Confidence 345556666666666777888888888776543210000111245566666666667778888888888776543310 Q NP_000290.2 322 -KLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST 360 (747) Q Consensus 322 -~~~ll~~~IL~~Ll~lL~ss~d~eVr~~AL~aLsnLas~ 360 (747) ........+++.+...+. +.++.++..++.++..+... T Consensus 183 ~~~~~~~~~~~~~l~~~l~-~~~~~vr~~a~~~l~~l~~~ 221 (249) T 2QK1_A 183 TLQRYLKDEVVPIVIQIVN-DTQPAIRTIGFESFAILIKI 221 (249) T ss_dssp HHHHHCCCCCHHHHHHHHT-CSSHHHHHHHHHHHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHc-CCCHHHHHHHHHHHHHHHHH Confidence 000111235555666665 55677888888888877653 No 499 >4D4Z_A DEOXYHYPUSINE HYDROXYLASE (E.C.1.14.99.29); OXIDOREDUCTASE, EIF-5A, HYPUSINE; HET: B3P, GOL; 1.7A {HOMO SAPIENS} Probab=67.63 E-value=0.43 Score=42.31 Aligned_cols=60 Identities=10% Similarity=0.123 Sum_probs=34.5 Template_Neff=12.700 Q NP_000290.2 547 DAIRTYLNLMGKSK--KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 547 G~I~~LL~LL~ss~--d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) ..++.|...+. +. ++.++..++.+|..+... ..++.+...+.+.++.++..++.+|..+. T Consensus 74 ~~~~~l~~~l~-~~~~~~~vr~~a~~~l~~~~~~----------------~~~~~l~~~l~~~~~~v~~~a~~~l~~~~ 135 (294) T 4D4Z_A 74 RAIPMLVDVLQ-DTRQEPMVRHEAGEALGAIGDP----------------EVLEILKQYSSDPVIEVAETCQLAVRRLE 135 (294) T ss_dssp GGHHHHHHHHH-CTTSCHHHHHHHHHHHHHHCCG----------------GGHHHHHHHTTCSSHHHHHHHHHHHHHHH T ss_pred chHHHHHHHhh-CCCCCHHHHHHHHHHHHHhCCH----------------HHHHHHHHHccCCCchHHHHHHHHHHHHH Confidence 34556666666 34 566777777776655421 12334455555556666666666666553 No 500 >4D50_A DEOXYHYPUSINE HYDROXYLASE (E.C.1.14.99.29); OXIDOREDUCTASE; HET: GAI; 1.7A {HOMO SAPIENS} Probab=67.63 E-value=0.43 Score=42.31 Aligned_cols=60 Identities=10% Similarity=0.123 Sum_probs=34.5 Template_Neff=12.700 Q NP_000290.2 547 DAIRTYLNLMGKSK--KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMS 623 (747) Q Consensus 547 G~I~~LL~LL~ss~--d~eVr~~AL~aL~nLs~~s~~~s~~~~~~llie~giI~~Ll~LL~s~d~eVr~~AL~aLsnLa 623 (747) ..++.|...+. +. ++.++..++.+|..+... ..++.+...+.+.++.++..++.+|..+. T Consensus 74 ~~~~~l~~~l~-~~~~~~~vr~~a~~~l~~~~~~----------------~~~~~l~~~l~~~~~~v~~~a~~~l~~~~ 135 (294) T 4D50_A 74 RAIPMLVDVLQ-DTRQEPMVRHEAGEALGAIGDP----------------EVLEILKQYSSDPVIEVAETCQLAVRRLE 135 (294) T ss_dssp GGHHHHHHHHH-CTTSCHHHHHHHHHHHHHHCCG----------------GGHHHHHHHTTCSSHHHHHHHHHHHHHHH T ss_pred chHHHHHHHhh-CCCCCHHHHHHHHHHHHHhCCH----------------HHHHHHHHHccCCCchHHHHHHHHHHHHH Confidence 34556666666 34 566777777776655421 12334455555556666666666666553 Query NP_000548.2 Match_columns 501 No_of_seqs 1691 out of 7065 Neff 7.55495 Searched_HMMs 400 Date Sat Jul 25 00:10:29 2020 Command /home/guerler/hh-suite/build/bin/hhblits -i /home/guerler/human/fasta/NP_00/NP_000548.2.fasta -d /home/guerler/pdb70/pdb70 -o /home/guerler/human/hhr/NP_00/NP_000548.2.hhr No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 5FFO_H Integrin alpha-V, Integ 100.0 2.3E-42 2.1E-46 353.3 0.0 315 143-501 24-363 (363) 2 3RJR_C Transforming growth fac 100.0 3.4E-42 3.1E-46 351.8 0.0 315 143-501 24-363 (363) 3 5VQF_C Transforming growth fac 100.0 3.4E-42 3.2E-46 351.8 0.0 315 143-501 24-363 (363) 4 5NTU_A Growth/differentiation 100.0 9.5E-42 8.8E-46 343.8 0.0 309 142-501 17-335 (335) 5 5HLY_A Inhibin beta A chain; G 100.0 3E-39 2.7E-43 332.7 0.0 307 142-501 40-383 (383) 6 6SF3_B Serine/threonine-protei 99.8 1.5E-26 1.3E-30 194.7 0.0 105 397-501 4-108 (108) 7 4MPL_A Growth/differentiation 99.8 2.3E-26 2E-30 196.3 0.0 106 396-501 10-116 (116) 8 6Z3J_B Growth/differentiation 99.8 2.6E-26 2.3E-30 196.2 0.0 107 395-501 11-117 (117) 9 5I05_A Growth/differentiation 99.8 4E-26 3.5E-30 192.9 0.0 106 396-501 4-110 (110) 10 4N1D_A Bone morphogenetic prot 99.8 4.5E-26 3.9E-30 194.5 0.0 106 396-501 11-116 (116) 11 2QCQ_B Bone morphogenetic prot 99.8 5.7E-26 5E-30 191.9 0.0 105 397-501 5-110 (110) 12 1LXI_A BONE MORPHOGENETIC PROT 99.8 9E-26 7.8E-30 198.7 0.0 111 391-501 29-139 (139) 13 6OMN_G Bone morphogenetic prot 99.8 9.8E-26 8.7E-30 189.8 0.0 105 396-501 4-108 (108) 14 2R53_A Bone morphogenetic prot 99.8 9.9E-26 8.7E-30 192.3 0.0 106 396-501 11-116 (116) 15 2R53_B Bone morphogenetic prot 99.8 9.9E-26 8.7E-30 192.3 0.0 106 396-501 11-116 (116) 16 1REU_A bone morphogenetic prot 99.8 1.1E-25 1E-29 187.7 0.0 102 399-501 2-103 (103) 17 1M4U_L Bone Morphogenetic Prot 99.8 1.2E-25 1.1E-29 197.8 0.0 111 391-501 29-139 (139) 18 2H62_B Bone morphogenetic prot 99.8 2.1E-25 1.9E-29 189.6 0.0 105 396-501 10-114 (114) 19 6Q2J_B Growth/differentiation 99.8 3.8E-25 3.2E-29 193.7 0.0 102 396-501 34-135 (135) 20 1KTZ_A TRANSFORMING GROWTH FAC 99.8 7.5E-25 6.6E-29 185.6 0.0 102 395-501 10-112 (112) 21 5TY4_B TGF-beta receptor type- 99.8 9.9E-25 8.8E-29 179.9 0.0 96 400-500 1-97 (97) 22 5VT2_B Growth/differentiation 99.8 1.1E-24 9.5E-29 184.6 0.0 102 396-501 11-112 (112) 23 5VZ3_A Growth/differentiation 99.8 1.1E-24 9.5E-29 184.6 0.0 102 396-501 11-112 (112) 24 2ARP_A Inhibin beta A chain, F 99.8 1.3E-24 1.2E-28 184.9 0.0 105 397-501 8-116 (116) 25 2ARV_A Inhibin beta A chain; h 99.8 1.3E-24 1.2E-28 184.9 0.0 105 397-501 8-116 (116) 26 2P6A_B Activin A, Follistatin 99.8 1.3E-24 1.2E-28 184.9 0.0 105 397-501 8-116 (116) 27 2TGI_A TRANSFORMING GROWTH FAC 99.8 1.5E-24 1.3E-28 183.7 0.0 101 396-501 11-112 (112) 28 3HH2_B Growth/differentiation 99.8 2.4E-24 2.1E-28 181.5 0.0 99 396-501 11-109 (109) 29 5F3B_C RK35 Chimeric antibody 99.8 2.4E-24 2.1E-28 181.5 0.0 99 396-501 11-109 (109) 30 3KFD_D Transforming growth fac 99.8 3.7E-24 3.2E-28 181.3 0.0 102 395-501 10-112 (112) 31 5E4G_A Growth/differentiation 99.8 1.2E-23 1.1E-27 177.0 0.0 99 396-501 11-109 (109) 32 5NMZ_B Neurturin; cystine knot 99.7 2.2E-22 1.9E-26 167.0 0.0 93 397-501 4-101 (101) 33 5NMZ_C Neurturin; cystine knot 99.7 2.2E-22 1.9E-26 167.0 0.0 93 397-501 4-101 (101) 34 2GH0_C artemin, GDNF family re 99.7 2.9E-22 2.6E-26 166.0 0.0 95 398-501 2-100 (101) 35 5MR4_B Neurturin, GDNF family 99.7 4.4E-22 3.9E-26 165.4 0.0 94 396-501 4-102 (102) 36 2V5E_B GDNF FAMILY RECEPTOR AL 99.7 7.4E-22 6.6E-26 163.6 0.0 93 397-501 5-101 (101) 37 2ASK_B artemin; Glial cell der 99.7 9.1E-22 8E-26 166.6 0.0 94 396-501 12-112 (113) 38 3FUB_D GDNF family receptor al 99.7 9.6E-22 8.1E-26 171.2 0.0 96 394-501 35-134 (134) 39 1AGQ_C GLIAL CELL-DERIVED NEUR 99.7 2.2E-21 1.8E-25 169.0 0.0 95 395-501 37-135 (135) 40 5TX2_A Transforming growth fac 99.7 2.9E-21 2.5E-25 157.7 0.0 81 396-501 12-93 (93) 41 5TX4_B TGF-beta receptor type- 99.7 3E-21 2.6E-25 157.3 0.0 81 396-501 11-92 (92) 42 2GYZ_A neurotrophic factor art 99.6 1.4E-19 1.2E-23 150.9 0.0 89 399-497 1-97 (105) 43 6Q2S_B Ubiquitin-like protein 99.5 2.9E-18 2.5E-22 163.2 0.0 93 397-501 135-234 (235) 44 6GFF_E Transforming growth fac 98.9 1.1E-13 1E-17 131.1 0.0 158 143-316 22-193 (249) 45 6GFF_G Transforming growth fac 98.9 1.1E-13 1E-17 131.2 0.0 158 143-316 22-193 (249) 46 5HLZ_E Inhibin beta A chain; G 98.7 1.8E-12 1.6E-16 124.5 0.0 155 143-317 41-227 (270) 47 4YCG_B pro-BMP9 prodomain, hum 98.7 3.5E-12 3.2E-16 124.4 0.0 152 143-316 41-208 (296) 48 4YCI_B mouse pro-BMP9 prodomai 98.7 3.5E-12 3.2E-16 124.4 0.0 152 143-316 41-208 (296) 49 4NT5_A von Willebrand factor; 75.7 0.27 2.4E-05 38.0 0.0 65 422-501 37-101 (107) 50 2KD3_A Sclerostin; Protein, an 73.5 0.35 3E-05 38.0 0.0 73 419-501 39-112 (113) 51 4YU8_A Neuroblastoma suppresso 70.0 0.48 4.1E-05 38.5 0.0 88 398-501 32-120 (139) 52 2K8P_A Sclerostin; WNT SIGNALL 66.7 0.66 5.3E-05 39.9 0.0 74 419-501 71-144 (189) 53 4JPH_D Gremlin-2; Cystine knot 65.1 0.72 6E-05 37.9 0.0 88 398-501 51-138 (148) 54 4X1J_B Neuroblastoma suppresso 64.2 0.74 6.5E-05 35.8 0.0 88 398-501 17-105 (116) 55 5AEJ_A GREMLIN-1; SIGNALING PR 62.6 0.87 7.2E-05 37.6 0.0 87 397-501 59-147 (152) 56 5HK5_G Gremlin-2, Growth/diffe 61.9 0.91 7.6E-05 37.2 0.0 86 398-501 50-137 (147) 57 5BPU_A Frizzled-4; Wnt signall 57.8 1.2 0.0001 35.0 0.0 72 422-501 37-108 (122) 58 5BQ8_C Norrin; Wnt signalling 54.0 1.5 0.00013 34.3 0.0 93 398-501 16-108 (122) 59 5BQE_A Frizzled-4; Wnt signall 54.0 1.5 0.00013 34.3 0.0 93 398-501 16-108 (122) No 1 >5FFO_H Integrin alpha-V, Integrin beta-6, Transforming; Integrin, TGF-beta, CELL ADHESION; HET: MAN, NAG, BMA; 3.49A {Homo sapiens} Probab=100.00 E-value=2.3e-42 Score=353.27 Aligned_cols=315 Identities=24% Similarity=0.379 Sum_probs=194.7 Template_Neff=9.300 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG----N--SSVKLEAGLANTITSFIDKGQDDRG-P 215 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~----~--~~~~~~~~~~n~Vrsf~~~~~~~~~-~ 215 (501) .+||++|||+++|+.+.. .+.+++++|++||+.+........ . ..+.+.....++++++......... . T Consensus 24 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~s~~~~~~~~~~~~ 99 (363) T 5FFO_H 24 GQILSKLRLASPPSQGEV----PPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQ 99 (363) T ss_dssp HHHHHHTTCSSCCCSSSS----CSSCCCHHHHHHHHHHSCCCCC--------CCSSSSCEEEEEEECBCTTSSSTTTTCC T ss_pred HHHHHHcCCCCCCCCCCC----CCCCCCHHHHHHHHHHHhhccCCCCCCCCCCcccceeeeEEEEEEeecCccccccccc Confidence 689999999999987642 223568999999998765431100 0 0011222234556666533221100 1 Q NP_000548.2 216 VVRKQRYVFDISA----LEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG 290 (501) Q Consensus 216 ~~~~~~l~FnlSs----i~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g 290 (501) ......++|++++ ++. +.|.+|+||||+..... ...|.||..... ....+++++.+.....++ T Consensus 100 ~~~~~~~~F~is~~~~~~~~~~~v~~AeLrl~~~~~~~-----------~~~v~iy~~~~~-~~~~~~~~~~~~~~~~~~ 167 (363) T 5FFO_H 100 STHSIYMFFQTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSQ-NSWRYLSNRLLAPSDSPE 167 (363) T ss_dssp BTTEEEEEECSTTHHHHSCSGGGEEEEEEECCBCCCCS-----------CCEEEEEEEETT-TEEEEEEEEECCCCSSCC T ss_pred ccceEEEEEechhccccCCCchhhcHhhhHhhcCccCc-----------cEEEEEEEecCc-ccceeeEeEEeCCCCCCC Confidence 2345678999997 433 57999999999887532 345677765421 111233333221234579 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA--QLCLELEAWERG----RAVDLRGLGFDR------AARQVHEKALFLVFGRTKKRDLFFNEI 358 (501) Q Consensus 291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~~~~----~~~~v~~~~~~~------~~~~~~~~ppLLv~~~~~~~~~~~~~~ 358 (501) |+.||||.+|+.|+.++ ++||.|.+.... ....+...++.. .......+|+|++++.+.... T Consensus 168 W~~fdVt~~v~~W~~~~~~n~gl~v~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~P~Lv~~~~~~~~~------ 241 (363) T 5FFO_H 168 WLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERA------ 241 (363) T ss_dssp CCEEECHHHHHHHHHSCCSCEEEEEEECCBTTTTBCCCCCCBSCCTTTCCSSGGGGGGTTCCEEEEEECCTTTC------ T ss_pred eEEEEcHHHHHHHHHcCCccccEEEEEEecCCCCCCceeeeeccccCCcccchhhccccCCcEEEEEeCchHHH------ Confidence 99999999999999997 788886554311 111110101100 011124566666666432210 Q NP_000548.2 359 KARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPL 437 (501) Q Consensus 359 ~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~ 437 (501) . ..+.+++ ||+. + ...+.......||+++++|+|+ ||||+ |||+|++|+||||.|.|+++. T Consensus 242 ----~--------~~~~~r~-rr~~---~-~~~~~~~~~~~Cc~~~l~V~F~~~lgw~-~iiaP~~~~a~~C~G~C~~~~ 303 (363) T 5FFO_H 242 ----Q--------HLQSSRH-RRAL---D-TNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIW 303 (363) T ss_dssp ----C-------------------------------CCSSSSEEECCCBCHHHHTCCC-SEEECCCBCCCEEECCCCCSC T ss_pred ----H--------hhhHHhh-Hhhc---c-cCCCCCCCcccceeeEEEEEccHHhCCc-eeeCCCeEEeeeccCCCCCcc Confidence 0 0000111 1110 1 1122233467899999999996 99998 999999999999999999997 Q NP_000548.2 438 RSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 438 ~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) .. +++|+.++++++...+..++.|||+|++|++|+|||+|++ .++++.++||+|++|||+ T Consensus 304 ~~---~t~ha~i~~~~~~~~~~~~~~~CC~P~~~~~l~ily~d~~-~~~~~~~~~m~v~~CgC~ 363 (363) T 5FFO_H 304 SL---DTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGR-KPKVEQLSNMIVRSCKCS 363 (363) T ss_dssp SC---C-----CCSSCTTTCSSCCSSCCEEECCEEEEEEEECC-C-CCEEEEEEEEEECCEEEC T ss_pred cc---cccHHHHHHHHHhhCCCCCCCCCcccceeceeeEEEEeCC-eeEEEEecCcEEeccCCC Confidence 63 5688988888776555568999999999999999999987 588999999999999995 No 2 >3RJR_C Transforming growth factor beta-1; TGF beta, activation, integrin, Cytokine; HET: NAG; 3.05A {Sus scrofa} Probab=100.00 E-value=3.4e-42 Score=351.82 Aligned_cols=315 Identities=24% Similarity=0.389 Sum_probs=198.8 Template_Neff=9.400 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG----NS--SVKLEAGLANTITSFIDKGQDDRG-P 215 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~----~~--~~~~~~~~~n~Vrsf~~~~~~~~~-~ 215 (501) .+||++|||+++|+.... .+.+++++|++||+.+........ .. .+.+......+++++......... . T Consensus 24 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 99 (363) T 3RJR_C 24 GQILSKLRLASPPSQGDV----PPGPLPEAVLALYNSTRDRVAGESVEPEPEPEADYYAKEVTRVLMVESGNQIYDKFKG 99 (363) T ss_pred HHHHHHcCCCCCCCCCCC----CCCCCCHHHHHHHHhhcccccCCcCCCCCCCcccccchhccceEeecCCcccccccCC Confidence 689999999999987641 223568999999997654321100 00 001111122333333221110000 1 Q NP_000548.2 216 VVRKQRYVFDISAL----EK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG 290 (501) Q Consensus 216 ~~~~~~l~FnlSsi----~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g 290 (501) ......+.|+++++ +. +.|.+|+||||+..... ...+.||..... ....++.++.+.....++ T Consensus 100 ~~~~~~~~F~~s~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~-~~~~~~~~~~~~~~~~~g 167 (363) T 3RJR_C 100 TPHSLYMLFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSQ-DSWRYLSNRLLAPSDSPE 167 (363) T ss_pred CccEEEEEEEcccCCCCCCcchhceEEEEEEEeCCCCC-----------CceEEEEEecCh-hheeEEEEEEeccCCCCc Confidence 13466899999974 22 47999999999887542 235667754321 111233333221234579 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA--QLCLELEAWER--G--RAVDLRGLGFDR------AARQVHEKALFLVFGRTKKRDLFFNEI 358 (501) Q Consensus 291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~~~--~--~~~~v~~~~~~~------~~~~~~~~ppLLv~~~~~~~~~~~~~~ 358 (501) |+.|||+.+|+.|+.++ ++||.|.+... . ..+.+...++.. .......+|+|++++.+.... T Consensus 168 W~~fdVt~~v~~W~~~~~~n~gl~l~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~P~Lv~~~~~~~~~------ 241 (363) T 3RJR_C 168 WLSFDVTGVVRQWLTRREAIEGFRLSAHCSCDSKDNTLHVEINGFNSGRRGDLATIHGMNRPFLLLMATPLERA------ 241 (363) T ss_pred EEEEECHHHHHHHHhCCcccCcEEEEEEEccCCCCceeeEEEccccCCCcCCcccccccCCCEEEEEEcCCccc------ Confidence 99999999999999997 78888655321 1 111111001100 001124566666666432210 Q NP_000548.2 359 KARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPL 437 (501) Q Consensus 359 ~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~ 437 (501) ...+.++ +||+. + ...+.......||+++++|+|+ ||||+ |||+|++|+||||.|.|+++. T Consensus 242 ------------~~~~~~r-~rr~~---~-~~~~~~~~~~~Ccr~~l~V~F~~~lgW~-wIiaP~~y~a~~C~G~C~~~~ 303 (363) T 3RJR_C 242 ------------QHLHSSR-HRRAL---D-TNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIW 303 (363) T ss_pred ------------ccccccc-ccccC---C-CCCCCCCCCCcccceeEEEecchhhCCc-eEecCCeEEeeeecccCCCCC Confidence 0000011 11110 1 1122223467899999999997 99997 999999999999999999997 Q NP_000548.2 438 RSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 438 ~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) .. .++|+.++++++...+..++.|||+|++|++|+|||+|++ ++++++++||+|++|||+ T Consensus 304 ~~---~t~ha~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~-~~~~~~~~~mvv~~CgC~ 363 (363) T 3RJR_C 304 SL---DTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGR-KPKVEQLSNMIVRSCKCS 363 (363) T ss_pred CC---cCcHHHHHHHHHhcCCCCCCCCcccccccCceEEEEEcCC-cEEEEEeCCeEEeeccCC Confidence 63 5689999988876555578999999999999999999987 588999999999999995 No 3 >5VQF_C Transforming growth factor beta-1; pro-complex, latency, homodimer, PROTEIN BINDING; HET: NAG, BMA; 2.9A {Sus scrofa} Probab=100.00 E-value=3.4e-42 Score=351.78 Aligned_cols=315 Identities=24% Similarity=0.389 Sum_probs=197.2 Template_Neff=9.400 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG----NS--SVKLEAGLANTITSFIDKGQDDRG-P 215 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~----~~--~~~~~~~~~n~Vrsf~~~~~~~~~-~ 215 (501) .+||++|||+++|++... .+.+++++|++||+.+........ .. .+.+.....++++++......... . T Consensus 24 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 99 (363) T 5VQF_C 24 GQILSKLRLASPPSQGDV----PPGPLPEAVLALYNSTRDRVAGESVEPEPEPEADYYAKEVTRVLMVESGNQIYDKFKG 99 (363) T ss_dssp HHHHHHTTCSSCCCCTTC----CCSCCCHHHHHHHHHHHCCCBCC-------CCCCSSCEEEEEEECCCSSSSTTTSSTT T ss_pred HHHHHHcCCCCCCCCCCC----CCCCCCHHHHHHHHHHhhhcCCCCCCCCCCChhhheeeEEEEEEEeecCCceecccCC Confidence 689999999999987641 223568999999997655421100 00 001111122333333221110000 1 Q NP_000548.2 216 VVRKQRYVFDISAL----EK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG 290 (501) Q Consensus 216 ~~~~~~l~FnlSsi----~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g 290 (501) ......+.|+++++ +. +.|.+|+||||+..... ...+.||..... ....++.++.+.....++ T Consensus 100 ~~~~~~l~F~~s~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~-~~~~~~~~~~~~~~~~~g 167 (363) T 5VQF_C 100 TPHSLYMLFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSQ-DSWRYLSNRLLAPSDSPE 167 (363) T ss_dssp CTTEEEEEEEHHHHHHHCSSGGGEEEEEEEEEECCCSS-----------CEEEEEEEECSS-SCEEEEEEEEECCCSSCE T ss_pred CCCeEEEEEEhhhccccCCCccceeeeEEEEEEcCCcc-----------ceEEEEEEecCc-ccceeEEeEEeCCCCCCC Confidence 13466899999974 22 47999999999887542 245667754321 111233333221234579 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA--QLCLELEAWER--G--RAVDLRGLGFDR------AARQVHEKALFLVFGRTKKRDLFFNEI 358 (501) Q Consensus 291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~~~--~--~~~~v~~~~~~~------~~~~~~~~ppLLv~~~~~~~~~~~~~~ 358 (501) |+.|||+.+|+.|+.++ +++|.|.+... . ..+.+...++.. .......+|+|++++.+.... T Consensus 168 W~~fdvt~~v~~W~~~~~~n~gl~l~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~P~Lvi~~~~~~~~------ 241 (363) T 5VQF_C 168 WLSFDVTGVVRQWLTRREAIEGFRLSAHCSCDSKDNTLHVEINGFNSGRRGDLATIHGMNRPFLLLMATPLERA------ 241 (363) T ss_dssp EEEEECHHHHHHHHHCCCSEEEEEEEECEEEEEETTEEEEEEC------CCCSBCCSSTTCCEEEEEECCSTTT------ T ss_pred eEEEEcHHHHHHHHhhchhcCCEEEEEEeecCCCCCceeeEEccccCCCccchhhccccCCcEEEEEEChhHHh------ Confidence 99999999999999997 78888655321 1 111111001100 001124566666666432110 Q NP_000548.2 359 KARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPL 437 (501) Q Consensus 359 ~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~ 437 (501) ...+.++ +||+. . ...+.......||+++++|+|+ ||||| |||+|++|+||||.|.|+++. T Consensus 242 ------------~~~~~~r-~rr~~---~-~~~~~~~~~~~Ccr~~l~V~F~~~lgWd-wIiaP~~y~a~~C~G~C~~~~ 303 (363) T 5VQF_C 242 ------------QHLHSSR-HRRAL---D-TNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIW 303 (363) T ss_dssp ------------CC---------CE---E-HHHHTTSCCSSSEEECCEEETTTTTCCC-CEEECSEEECCEEECCCCCTT T ss_pred ------------hccchhh-hhhcc---C-cCccCCCCCccceeeEEEEEcchhhCCc-eeeCCCeEEeEeecCCCCCcC Confidence 0000011 11110 1 1122223467899999999997 99997 999999999999999999997 Q NP_000548.2 438 RSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 438 ~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) .. .++|+.++++++...+..++.|||+|++|++|+|||+|++ +++++.++||+|++|||+ T Consensus 304 ~~---~t~ha~v~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~-~~~~~~~~~miv~~CgC~ 363 (363) T 5VQF_C 304 SL---DTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGR-KPKVEQLSNMIVRSCKCS 363 (363) T ss_dssp TS---CSCCHHHHTGGGGCCGGGSSSCCEEESSEEEEEEEEEETT-EEEEEEEEEEEECEEEEC T ss_pred Cc---cccHHHHHHHHHhcCCCCCCCCCccCcccceeeEEEEECC-eeEEEEecCcEEeccCCC Confidence 63 5689999988876555578999999999999999999987 588999999999999995 No 4 >5NTU_A Growth/differentiation factor 8; growth factor, signalling protein, TGFbeta; HET: EDO; 2.58A {Homo sapiens} Probab=100.00 E-value=9.5e-42 Score=343.78 Aligned_cols=309 Identities=22% Similarity=0.402 Sum_probs=196.1 Template_Neff=9.900 Q NP_000548.2 142 SSFLLKKAREPGPPREPKEPFR-P-PPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRK 219 (501) Q Consensus 142 ~~qIL~kLGL~~~P~~~~~~~~-~-~~~~~p~~MldLY~~~~~~~~~~~~~~~~~~~~~~n~Vrsf~~~~~~~~~~~~~~ 219 (501) -.+||++|||+++|++....++ . +..+++++|+++|+.+....... ...++++...+++|++|.............. T Consensus 17 k~~IL~~LgL~~~P~~~~~~~~~~~~~~~~~~~l~~~y~~~~~~~~~~-~~~~~~~~~~~~~v~~f~~~~~~~~~~~~~~ 95 (335) T 5NTU_A 17 KIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDG-SLEDDDYHATTETIITMPTESDFLMQVDGKP 95 (335) T ss_pred HHHHHHHcCCCCCCCCCCCCCcccCCCCCchHHHHHHHhhccCCCCCC-CCcccchhcccceEEEeccCCCcccCCCCCC Confidence 4689999999999998763110 0 11225799999999765432110 0011223345567888865432210001245 Q NP_000548.2 220 QRYVFDISALEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGR---QPAALLDVRSVP-GLDGSGWEVF 294 (501) Q Consensus 220 ~~l~FnlSsi~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~---~~~~ll~s~~v~-~~~~~gWv~f 294 (501) ..++|+++++.. +.|.+|+||||+...... ....+.||...... .....+....+. ....++|++| T Consensus 96 ~~~~F~ls~~~~~~~v~~AeL~l~~~~~~~~---------~~~~v~vy~v~~~~~~~~~~~~~~~~~~~~~~~~~gW~~f 166 (335) T 5NTU_A 96 KCCFFKFSSKIQYNKVVKAQLWIYLRPVETP---------TTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSI 166 (335) T ss_pred eEEEEECCCCCCCcceeEEEEEEEECCCCCC---------CeEEEEEEEEEccCcCCceeeeeeEEEEEccCCCCcEEEE Confidence 678999997654 589999999999875431 13456666543210 000011111111 1234699999 Q NP_000548.2 295 DIWKLFRNFKNSA--QLCLELEAWERG-RAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYE 371 (501) Q Consensus 295 DVT~aV~~Wl~~~--nlgL~V~~~~~~-~~~~v~~~~~~~~~~~~~~~ppLLv~~~~~~~~~~~~~~~~~~~~~~~~~~~ 371 (501) |||.+|++|+.++ ++||.|.+...+ ....+ .+.... ....+|+|++++.+.. T Consensus 167 dVt~~v~~W~~~~~~n~gl~v~~~~~~~~~~~~---~~~~~~-~~~~~P~Lvi~~~~~~--------------------- 221 (335) T 5NTU_A 167 DVKTVLQNWLAAPASNLGIEIKALDENGHDLAV---TFPGPG-EDGLNPFLEVKVTDTP--------------------- 221 (335) T ss_pred EcHHHHHHHHHCCccCceEEEEEEeCCCCeEee---ecCCCC-CcccCcEEEEEecCCC--------------------- Confidence 9999999999986 789988775432 11111 111111 1234555555542110 Q NP_000548.2 372 YLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQT 451 (501) Q Consensus 372 ~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~ 451 (501) .++ +|. ....|........||+++++|+|+||||+ |||+|++|+||||.|.|+++.... ++|+. T Consensus 222 ----~~~-~r~----~~~~~~~~~~~~~Ccr~~l~V~F~~igW~-wIiaP~~y~a~~C~G~C~~~~~~~---~~~~~--- 285 (335) T 5NTU_A 222 ----KRS-RRD----FGLDCDEHSTESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLAA---YPHTH--- 285 (335) T ss_pred ----ccc-ccc----CCCCCCCCCCCCCceeeEEEEEHHHcCCc-eeecCCeEEeEeeCccCCCCcccc---CCCch--- Confidence 111 111 10123233357899999999999999998 999999999999999999998642 24442 Q NP_000548.2 452 LMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 452 ~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +++...+...+.|||+|++|++|+|||+|++++++++.++||+|++|||+ T Consensus 286 ~~~~~~~~~~~~pCC~P~~~~~l~ily~~~~~~i~~~~~~~mvv~~CgC~ 335 (335) T 5NTU_A 286 LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS 335 (335) T ss_pred hHhccCCCCCCCCcccceeccceEEEEECCCCCEEEEEeCCceeeccccC Confidence 23333333578999999999999999999887889999999999999995 No 5 >5HLY_A Inhibin beta A chain; Growth factor, Precursor, Signalling, Signaling; HET: MSE; 2.302A {Homo sapiens} Probab=100.00 E-value=3e-39 Score=332.69 Aligned_cols=307 Identities=21% Similarity=0.407 Sum_probs=167.2 Template_Neff=8.800 Q NP_000548.2 142 SSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKG------GN----SSVKLEAGLANTITSFIDKGQD 211 (501) Q Consensus 142 ~~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~------~~----~~~~~~~~~~n~Vrsf~~~~~~ 211 (501) =.+||++|||+++|+++.. . +.+..+..+|+.+....... .+ .+.+.+...++.|+.|.... T Consensus 40 K~~IL~kLgL~~~P~~~~~----~--p~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~t~~ii~f~~~~-- 111 (383) T 5HLY_A 40 KKHILNMLHLKKRPDVTQP----V--PKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESG-- 111 (383) T ss_dssp HHHHHHHTTCSSCCCCCCC----S--CHHHHHHHHHHTTSEEECGGGCEEETTCHHHHHHHHHHHHTEEEEEEECEEC-- T ss_pred HHHHHHHcCCCCCCCCCCC----C--CCHHHHHHHHHhhcCCCCCCCcccccCCCCCCCCccccccceeEEEEECcCC-- Confidence 3689999999999998752 1 11222234565443211000 00 00112223456666665432 Q NP_000548.2 212 DRGPVVRKQRYVFDISALE-K-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGR----------------- 272 (501) Q Consensus 212 ~~~~~~~~~~l~FnlSsi~-~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~----------------- 272 (501) .....++|++++.+ . +.|.+||||||+....... ......|.||...... T Consensus 112 -----~~~~~l~F~iS~~~~~~~~V~~AeL~l~~~~~~~~~------~~~~~~V~vy~~~~~~~~~~~~~~~~~~~~~~~ 180 (383) T 5HLY_A 112 -----TARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANR------TRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKG 180 (383) T ss_dssp -----SSTTEEEEHCCE-------EEEEEEEEEEECS----------------------------------SC----CEC T ss_pred -----CCeEEEEEEcCCCCCCcceeEEEEEEEEecCCCCCC------CCceEEEEEEEEecCCCCCCCCcchhHhhcCCc Confidence 13567899999754 2 4699999999998764320 1124567777543210 Q NP_000548.2 273 -QPAALLDVRSVPGLDGSGWEVFDIWKLFRNFKNSA--QLCLELEAWERGR-AVDLRGLGFDRAARQVHEKALFLVFGRT 348 (501) Q Consensus 273 -~~~~ll~s~~v~~~~~~gWv~fDVT~aV~~Wl~~~--nlgL~V~~~~~~~-~~~v~~~~~~~~~~~~~~~ppLLv~~~~ 348 (501) ....++.++.+ ....++|++||||.+|+.|+.++ +++|.|.+..... ...+ ...........+|+|++++.+ T Consensus 181 ~~~~~l~~s~~i-~~~~~gWi~fdVt~~V~~Wl~~~~~n~gl~v~~~~~~~~~~~l---~~~~~~~~~~~~P~Lvi~~~~ 256 (383) T 5HLY_A 181 ERSELLLSEKVV-DARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASL---VLLGEEKEQSHRPFLMLQARQ 256 (383) T ss_dssp CEEEEEEEEEEE-ECSSCEEEEEECHHHHHHHHHTTCCEEEEEEECTTTTTTTCEE---ECSCCGGGGGGCCEEEEEEEC T ss_pred ccceEEEEEEEE-eCCCCcEEEEEcHHHHHHHHhCCccCcceEEEEEcCCCCCceE---EEecCCCccccccEEEEEEcC Confidence 00112333333 23457999999999999999987 7888877653221 1101 000011112356666666532 Q NP_000548.2 349 KKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFH 428 (501) Q Consensus 349 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~y 428 (501) ... . +++++++ . ..| ......||+++++|+|+||||++|||+|++|+|+| T Consensus 257 ~~~----------------------~-~~rr~~~----~-~~~--~~~~~~Cc~~~~~V~F~~lgw~~wIiaP~~y~a~~ 306 (383) T 5HLY_A 257 SED----------------------H-PHRRRRR----G-LEC--DGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANY 306 (383) T ss_dssp C-------------------------------------C-CBC--SSCSSBCEEECCEEETTTTTCTTTEEECSEEECCE T ss_pred ccc----------------------c-ccccccc----C-CCC--CCCCcccccceeeecHHHhCCcceeecCCEEEcee Confidence 110 0 0111111 0 112 12468999999999999999988999999999999 Q NP_000548.2 429 CEGLCEFPLRSHLE--PTNHAVIQTLMNS--MDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 429 C~G~C~~~~~~~~~--~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |.|.|+.+.....+ .++|+.+...+.. ..+...+.|||+|++|++++|||+|++++++++.++||+|++|||+ T Consensus 307 C~G~C~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~pCC~P~~~~~l~ily~~~~~~i~~~~~~~mvv~~CgC~ 383 (383) T 5HLY_A 307 CEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 383 (383) T ss_dssp EESBCC---------C---SCCC---------------CCCEEEEEEEEEEEEEES-SSCEEEEEEEEEEEEEEEEC T ss_pred ecccCCCCCCCCCCCcccHHHHHHHHHHhcCCCCCcCCCCcccccccCceEEEEEcCCCcEEEEEeCCcEEeecccC Confidence 99999998653211 1235433332211 1123568999999999999999999987889999999999999995 No 6 >6SF3_B Serine/threonine-protein kinase receptor R3 (E.C.2.7.11.30); BMP10, ALK1, complex, signalling, TGFbeta; 2.3000067422A {Homo sapiens} Probab=99.85 E-value=1.5e-26 Score=194.74 Aligned_cols=105 Identities=48% Similarity=1.049 Sum_probs=89.1 Template_Neff=8.600 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISI 476 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~i 476 (501) ...||+++++|+|+||||++|||+|++|+++||.|.|..+....++.++|+.++.+++...+.....|||+|++|++++| T Consensus 4 ~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l~i 83 (108) T 6SF3_B 4 GNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISI 83 (108) T ss_dssp -CBSEEECCEEETTTTTGGGTEEECSEEECCEEESBBCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCBCEEEEEEEEEEE T ss_pred CCcceEEEeEeeHHHhCCCceeeCCCceeceeeccccCCCCCCCCCCCchHHHHHHHHhhCccccCCCcccceecCceEE Confidence 56899999999999999988999999999999999999987643334578877776654434467899999999999999 Q NP_000548.2 477 LFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 477 ly~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ||+++++.++.+.++||+|++|||+ T Consensus 84 l~~~~~~~~~~~~~~~~~v~~C~C~ 108 (108) T 6SF3_B 84 LYLDKGVVTYKFKYEGMAVSECGCR 108 (108) T ss_dssp EEEETTEEEEEEEEEEEEEEEEEEC T ss_pred EEEECCeeEEEEEECCeEEeecccC Confidence 9999875555678999999999995 No 7 >4MPL_A Growth/differentiation factor 2; growth factor/cytokine, CYTOKINE; 1.9A {Homo sapiens} Probab=99.84 E-value=2.3e-26 Score=196.32 Aligned_cols=106 Identities=50% Similarity=1.028 Sum_probs=90.4 Template_Neff=7.900 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|++++.+++...+.....|||+|++|++++ T Consensus 10 ~~~~C~~~~l~V~F~dlgw~~~Ii~P~~~~~~yC~G~C~~~~~~~~~~t~ha~i~~~~~~~~~~~~~~~CC~P~~~~~l~ 89 (116) T 4MPL_A 10 AGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPIS 89 (116) T ss_dssp CCCCCEEECCEEETTTTTCTTTEEECSEEECCEEESCCCSSCCTTCCCCHHHHHHHHHHHHSTTTSCCCCEEEEEEEEEE T ss_pred CCCCCEEEEEEEeHHHhCCCCCeeCCCeeEeEEEcccCCCCCCCCCCCCchHHHHHHHhhcCCccCCCCceeeeEecCeE Confidence 35789999999999999998899999999999999999998765333457787777665443446789999999999999 Q NP_000548.2 476 ILFIDSANNVVYK-QYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~-~~~~mvv~~CgC~ 501 (501) |||+++++.++++ .++||+|++|+|+ T Consensus 90 ily~~~~~~~~~~~~~~~mvv~~CgC~ 116 (116) T 4MPL_A 90 VLYKDDMGVPTLKYHYEGMSVAECGCR 116 (116) T ss_dssp EEEECSSSCEEEEEEEEEEEEEEEEEC T ss_pred EEEECCCCcEEEEEEECCeEEeccccC Confidence 9999988666666 8999999999995 No 8 >6Z3J_B Growth/differentiation factor 5, RGM domain; Repulsive Guidance Molecule, RGM, Bone; HET: SO4, GOL, NAG, EDO; 1.65A {Homo sapiens} Probab=99.84 E-value=2.6e-26 Score=196.21 Aligned_cols=107 Identities=98% Similarity=1.618 Sum_probs=92.0 Template_Neff=8.300 Q NP_000548.2 395 NLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI 474 (501) Q Consensus 395 ~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l 474 (501) .....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++...+.....|||+|++|+++ T Consensus 11 ~~~~~Cc~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~i~~~~~~~~~~~~~~~cC~P~~~~~l 90 (117) T 6Z3J_B 11 NLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI 90 (117) T ss_dssp -CCCBSEEECCEEETTTTTGGGTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEE T ss_pred CCCCcceeEEEEEeHHHcCCCccEEcCCeeeceeeeecCCCCccccCCCChHHHHHHHHHhcCCCCCCCCcccceeecce Confidence 34789999999999999999889999999999999999999876433345788777766544445678999999999999 Q NP_000548.2 475 SILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 475 ~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +|+|+++++.++++.++||+|++|||+ T Consensus 91 ~ily~~~~~~~~~~~~~~~~v~~CgC~ 117 (117) T 6Z3J_B 91 SILFIDSANNVVKKDYEDMVVESCGCR 117 (117) T ss_dssp EEEEECTTSCEEEEEEEEEEEEEEEEC T ss_pred EEEEEcCCCcEEEEEECCeEEeeccCC Confidence 999999877788999999999999995 No 9 >5I05_A Growth/differentiation factor 2; GROWTH DIFFERENTIATION FACTOR 2, CELL; HET: GOL; 1.87A {Homo sapiens} Probab=99.84 E-value=4e-26 Score=192.88 Aligned_cols=106 Identities=50% Similarity=1.028 Sum_probs=90.1 Template_Neff=8.400 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|+||||++|||+|++|+++||.|.|..+....++.++|+.++.+++...+.....|||+|++|++++ T Consensus 4 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~ 83 (110) T 5I05_A 4 AGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPIS 83 (110) T ss_dssp CCCBSEEECCEEETTTTTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE T ss_pred CCCcceeEEEEEeHHHhCCCCcEeCCCccccEeecCCCCCCCCCCCCCChhHHHHHHHhhcCCCCCCCcccceeeecceE Confidence 35789999999999999998899999999999999999998764333457777776655443456789999999999999 Q NP_000548.2 476 ILFIDSANNVVYK-QYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~-~~~~mvv~~CgC~ 501 (501) |||+|++++++++ .++||+|++|||+ T Consensus 84 il~~~~~~~~~~~~~~~dm~v~~CgC~ 110 (110) T 5I05_A 84 VLYKDDMGVPTLKYHYEGMSVAECGCR 110 (110) T ss_dssp EEEECTTSCEEEEEEEEEEEEEEEEEC T ss_pred EEEECCCCcEEEEEEeCCeEEeecccC Confidence 9999998766666 8999999999995 No 10 >4N1D_A Bone morphogenetic protein 2; Cytokine, Signaling Protein; 1.912A {Homo sapiens} Probab=99.84 E-value=4.5e-26 Score=194.45 Aligned_cols=106 Identities=52% Similarity=1.077 Sum_probs=90.5 Template_Neff=8.300 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++...+.....|||+|++|++++ T Consensus 11 ~~~~Cc~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 90 (116) T 4N1D_A 11 LKSSCKRHPLYVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCVPTELSAIS 90 (116) T ss_dssp -C-BSEEECCEEETTTTTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE T ss_pred CCCcceeEEEEEEHHHhCCCCCEeCCCeeeceeeeEeCCCCCccCCCCChhHHHHHHHHhcCCCCCCCCceecceecceE Confidence 46789999999999999998899999999999999999988764333457887777765444446789999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|+++++.++++.++||+|.+|||+ T Consensus 91 il~~~~~~~~~~~~~~~~~v~~C~C~ 116 (116) T 4N1D_A 91 MLYLDENEKVVLKNYQDMVVEGCGCR 116 (116) T ss_dssp EEEECTTCCEEEEEEEEEEEEEEEEC T ss_pred EEEECCCCcEEEEEeCCeEEeccccC Confidence 99999877788999999999999995 No 11 >2QCQ_B Bone morphogenetic protein 3; BMP, TGF-beta, SIGNALING PROTEIN; 2.21A {Homo sapiens} Probab=99.83 E-value=5.7e-26 Score=191.87 Aligned_cols=105 Identities=46% Similarity=1.054 Sum_probs=89.3 Template_Neff=8.500 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMD-PESTPPTCCVPTRLSPIS 475 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~-~~~~~~pCC~P~~~~~l~ 475 (501) ...||+++++|+|+||||++|||+|++|+++||.|+|..+.....+.++|+.++.+++... ......|||+|++|++++ T Consensus 5 ~~~Cc~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~~~CC~P~~~~~l~ 84 (110) T 2QCQ_B 5 PRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLS 84 (110) T ss_dssp CSBSEEECCEEEGGGTTCTTTEEECSEEECCEEECBCCSSCCGGGCCCHHHHHHHHHHHSSCSTTCCCCCEEESSEEEEE T ss_pred CCcceeeEEEEeHHHhCCCcceeCCCeecceeeceeCCCCCCccCCCCcHHHHHHHHHHhCCCCCCCCCceeeEEeCceE Confidence 4689999999999999998899999999999999999998754333457777777655332 134679999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |||++++++++++.++||+|++|||+ T Consensus 85 il~~~~~~~~~~~~l~~~~v~~CgC~ 110 (110) T 2QCQ_B 85 ILFFDENKNVVLKVYPNMTVESCACR 110 (110) T ss_dssp EEEECTTCCEEEEEEEEEEECCEEEC T ss_pred EEEEcCCCcEEEEEECCeEEeccccC Confidence 99999887788899999999999995 No 12 >1LXI_A BONE MORPHOGENETIC PROTEIN 7; Cystine-knot growth factor, HORMONE-GROWTH FACTOR; HET: NAG; 2.0A {Homo sapiens} SCOP: g.17.1.2 Probab=99.83 E-value=9e-26 Score=198.70 Aligned_cols=111 Identities=48% Similarity=1.063 Sum_probs=90.2 Template_Neff=7.500 Q NP_000548.2 391 RPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTR 470 (501) Q Consensus 391 ~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~ 470 (501) +........||+++++|+|++|||++|||+|++|+++||.|.|..+.....+.++|++++.+++...+.....|||+|++ T Consensus 29 ~~~~~~~~~C~~~~~~V~f~~igw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~i~~l~~~~~~~~~~~~CC~P~~ 108 (139) T 1LXI_A 29 NSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQ 108 (139) T ss_dssp -------CBSEEECCEEEHHHHTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTCCCCCEEEEE T ss_pred cCCccccccceeeeeeccHHHhCCCCceecCCceeeeEecccCCCCcccccCCCHHHHHHHHHHhhCCCCCCCCceeeee Confidence 33445678999999999999999988999999999999999999887543234577777776654434467899999999 Q NP_000548.2 471 LSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 471 ~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |++++|||+++++.++++.++||+|++|||+ T Consensus 109 ~~~l~ily~d~~~~i~~~~l~~mvv~~CgC~ 139 (139) T 1LXI_A 109 LNAISVLYFDDSSNVILKKYRNMVVRACGCH 139 (139) T ss_dssp EEEEEEEEECTTSCEEEEEEEEEEEEEEEEC T ss_pred eCceEEEEECCCCCEEEEEEcCeEEecccCC Confidence 9999999999877788999999999999995 No 13 >6OMN_G Bone morphogenetic protein 2; BMP, Bone Mophogenetic Protein, CYTOKINE; HET: BMA, MAN, NAG; 2.68A {Homo sapiens} Probab=99.83 E-value=9.8e-26 Score=189.80 Aligned_cols=105 Identities=57% Similarity=1.165 Sum_probs=89.4 Template_Neff=8.400 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++... ...+.|||+|++|++++ T Consensus 4 ~~~~Cc~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~~~~~~~~~~-~~~~~~CC~P~~~~~l~ 82 (108) T 6OMN_G 4 LKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTELSAIS 82 (108) T ss_pred CCCCcEEEEeEEehHHcCCCccEECCCeeeeEEEcccCCCCCccccCCCchHHHHHHHhcCC-CCCCCCceeEEeeCceE Confidence 35789999999999999998899999999999999999988654333456777776654432 35689999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |||+++++.++++.++||+|++|||+ T Consensus 83 ily~~~~~~~~~~~~~~m~v~~CgC~ 108 (108) T 6OMN_G 83 MLYLDENEKVVLKNYQDMVVEGCGCR 108 (108) T ss_pred EEEECCCCcEEEEEeCCeEEeccccC Confidence 99999877788999999999999995 No 14 >2R53_A Bone morphogenetic protein 6; BMP6, Vgr, TGF-beta ligand, Chondrogenesis; HET: MPD; 2.1A {Homo sapiens} Probab=99.83 E-value=9.9e-26 Score=192.30 Aligned_cols=106 Identities=49% Similarity=1.068 Sum_probs=89.6 Template_Neff=8.200 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++.........|||+|++|++++ T Consensus 11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l~ 90 (116) T 2R53_A 11 RLKACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAIS 90 (116) T ss_dssp CSSBSEEECCEEEGGGTTCTTTEEECSEEECCEEECBCCSSCCTTTTSCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE T ss_pred ccCceEEEEEEEeHHHhCCCCcEecCCeEEeEEeceeCCCCCccccCCChHHHHHHHHHhcCCccCCCCeeeeeecCCeE Confidence 36799999999999999998799999999999999999998654323456777666554433345789999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|+++++.+++++++||+|++|||. T Consensus 91 il~~~~~~~~~~~~l~~~~v~~C~C~ 116 (116) T 2R53_A 91 VLYFDDNSNVILKKYRNMVVRACGCH 116 (116) T ss_dssp EEEECTTCCEEEEEEEEEEEEEEEEC T ss_pred EEEECCCCcEEEEEEcCeEEecccCC Confidence 99999877788899999999999995 No 15 >2R53_B Bone morphogenetic protein 6; BMP6, Vgr, TGF-beta ligand, Chondrogenesis; HET: MPD; 2.1A {Homo sapiens} Probab=99.83 E-value=9.9e-26 Score=192.30 Aligned_cols=106 Identities=49% Similarity=1.068 Sum_probs=89.6 Template_Neff=8.200 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++.........|||+|++|++++ T Consensus 11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l~ 90 (116) T 2R53_B 11 RLKACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAIS 90 (116) T ss_dssp CSSBSEEECCEEEHHHHTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE T ss_pred ccCceEEEEEEEeHHHhCCCCcEecCCeEEeEEeceeCCCCCccccCCChHHHHHHHHHhcCCccCCCCeeeeeecCCeE Confidence 36799999999999999998799999999999999999998654323456777666554433345789999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|+++++.+++++++||+|++|||. T Consensus 91 il~~~~~~~~~~~~l~~~~v~~C~C~ 116 (116) T 2R53_B 91 VLYFDDNSNVILKKYRNMVVRACGCH 116 (116) T ss_dssp EEEECTTSCEEEEEEEEEEEEEEEEC T ss_pred EEEECCCCcEEEEEEcCeEEecccCC Confidence 99999877788899999999999995 No 16 >1REU_A bone morphogenetic protein 2; TGF-beta fold, HORMONE-GROWTH FACTOR COMPLEX; HET: MPD; 2.65A {Homo sapiens} SCOP: g.17.1.2 Probab=99.83 E-value=1.1e-25 Score=187.67 Aligned_cols=102 Identities=56% Similarity=1.151 Sum_probs=87.5 Template_Neff=8.600 Q NP_000548.2 399 RCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILF 478 (501) Q Consensus 399 ~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily 478 (501) .||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++... ...+.|||+|++|++++||| T Consensus 2 ~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~~i~~~~~~~~-~~~~~~cC~P~~~~~l~ily 80 (103) T 1REU_A 2 SCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPPADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTELSAISMLY 80 (103) T ss_dssp BSEEECCEEETTTTTCTTTCCBCSEEECCEEECBCCSSCCSSSCBCHHHHHHHHHHHHC-SSSCCCCEEEEEEEEEEEEE T ss_pred CceEEEeEecHHHcCCCCcEeCCCeecceEEeeeCCCCCcccCCCChhHHHHHHHhhcC-CCCCCccceeeEeCceEEEE Confidence 69999999999999998899999999999999999998754333456777776654332 35689999999999999999 Q NP_000548.2 479 IDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 479 ~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ++++++++++.++||+|++|||+ T Consensus 81 ~~~~~~~~~~~~~~~~v~~CgC~ 103 (103) T 1REU_A 81 LDENEKVVLKNYQDMVVEGCGCR 103 (103) T ss_dssp ECTTCCEEEEEEEEEEEEEEEEC T ss_pred EcCCCcEEEEEeCCeEEeccccC Confidence 99877788999999999999995 No 17 >1M4U_L Bone Morphogenetic Protein-7/Noggin; NOGGIN, BMP ANTAGONIST, BMP-7, BONE; HET: NAG; 2.42A {Homo sapiens} SCOP: g.17.1.2 Probab=99.82 E-value=1.2e-25 Score=197.81 Aligned_cols=111 Identities=48% Similarity=1.063 Sum_probs=88.2 Template_Neff=7.500 Q NP_000548.2 391 RPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTR 470 (501) Q Consensus 391 ~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~ 470 (501) +........||+++++|+|++|||++|||+|++|+++||.|.|..+.....+.++|++++.+++...+.....|||+|++ T Consensus 29 ~~~~~~~~~C~~~~~~V~f~~igw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~l~~l~~~~~~~~~~~pCC~P~~ 108 (139) T 1M4U_L 29 NSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQ 108 (139) T ss_dssp ---------SEEECCEEESGGGTCTTTEEECSEEECCEEECBCCSSEEGGGCCCHHHHHHHHHHHHCTTSSCCCCEEEEE T ss_pred ccCCCCCCcccceecccCHHHhCCCCceecCCeecceeecccCCCCCccccCCCHHHHHHHHHHhcCCCCCCCCceeeee Confidence 33445678999999999999999988999999999999999999887533234577777776654434467899999999 Q NP_000548.2 471 LSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 471 ~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |++++|||+++++.++++.++||+|++|||+ T Consensus 109 ~~~l~ily~d~~~~i~~~~l~~mvv~~CgC~ 139 (139) T 1M4U_L 109 LNAISVLYFDDSSNVILKKYRNMVVRACGCH 139 (139) T ss_dssp EEEEEEEEECTTSCEEEEEEEEEEEEEEEES T ss_pred cCCeEEEEECCCCCEEEEEECCeEEeccccC Confidence 9999999999877788999999999999995 No 18 >2H62_B Bone morphogenetic protein 2, Bone; TGF-beta superfamily, ligand-receptor complex, HORMONE-GROWTH; 1.85A {Homo sapiens} SCOP: g.17.1.2 Probab=99.82 E-value=2.1e-25 Score=189.59 Aligned_cols=105 Identities=57% Similarity=1.165 Sum_probs=88.7 Template_Neff=8.300 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|++|||++|||+|++|+++||.|.|..+.....+.++|+.++.+++... .....|||+|++|++++ T Consensus 10 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~~~~~~~~~~-~~~~~~CC~P~~~~~l~ 88 (114) T 2H62_B 10 LKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTELSAIS 88 (114) T ss_dssp --CBSEEECCEEEGGGTTCTTTEEECSEEECCEEECBCCSSCCGGGCCCHHHHHHHHHHHHC-TTSCCCCEEEEEEEEEE T ss_pred ccCcceEEEEEEehHHcCCCCcEeCCCeeeceEEeeeCCCCCccccCCCchHHHHHHHHhcC-CCCCCccceeeEeCceE Confidence 46789999999999999998899999999999999999988754333456777776654332 35689999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|+|++++++++.++||+|++|+|+ T Consensus 89 ily~~~~~~~~~~~~~~~~v~~C~C~ 114 (114) T 2H62_B 89 MLYLDENEKVVLKNYQDMVVEGCGCR 114 (114) T ss_dssp EEEEETTTEEEEEEEEEEEEEEEEEC T ss_pred EEEECCCCcEEEEEeCCeEEeccccC Confidence 99999877788999999999999995 No 19 >6Q2J_B Growth/differentiation factor 15, GDNF family; RET, receptor tyrosine kinase, cryo-EM; HET: NAG; 4.1A {Homo sapiens} Probab=99.81 E-value=3.8e-25 Score=193.68 Aligned_cols=102 Identities=27% Similarity=0.754 Sum_probs=85.9 Template_Neff=7.400 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....|++++++|+|+||||++|||+|++|+++||.|.|..+... .++|+.++.+++...+..+..|||+|++|++++ T Consensus 34 ~~~cC~~~~~~V~F~dlGw~~wIi~P~~~~~~~C~G~C~~~~~~---~t~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 110 (135) T 6Q2J_B 34 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMV 110 (135) T ss_pred CcCcceeEEEEEeHHHcCCCCcEECCCeEEeEEecccCCCCCCC---CChHHHHHHHHHhcCCCCCCCCceeeeeecceE Confidence 34445458999999999997799999999999999999988753 346777777665444456789999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|++++ .++++.++||+|++|||+ T Consensus 111 ily~~~~-~i~~~~l~dmvv~~CgC~ 135 (135) T 6Q2J_B 111 LIQKTDT-GVSLQTYDDLLAKDCHCI 135 (135) T ss_pred EEEECCC-eEEEEEECCeEEeccccC Confidence 9998874 788899999999999995 No 20 >1KTZ_A TRANSFORMING GROWTH FACTOR BETA 3/TGF-beta; CYTOKINE-RECEPTOR COMPLEX, CYTOKINE-CYTOKINE RECEPTOR COMPLEX; 2.15A {Homo sapiens} SCOP: g.17.1.2 Probab=99.80 E-value=7.5e-25 Score=185.60 Aligned_cols=102 Identities=35% Similarity=0.837 Sum_probs=76.2 Template_Neff=8.200 Q NP_000548.2 395 NLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSP 473 (501) Q Consensus 395 ~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~ 473 (501) .....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+... .++|+.++.+++...+...+.|||+|++|++ T Consensus 10 ~~~~~Cc~~~~~V~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~ 85 (112) T 1KTZ_A 10 NLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRSA---DTTHSTVLGLYNTLNPEASASPCCVPQDLEP 85 (112) T ss_dssp ---CCCEEECCEEECCCCCCCC-CEEECSEEECCEEECCCCSSCCC---------------------CCCCCEEECCEEE T ss_pred cccCCcEEEEEEEECchhcCCC-eeeCCCeeeeeeeeecCCCCCCC---CCChHHHHHHHHhcCcccCCCCcccceecCc Confidence 3478999999999999 99998 99999999999999999998753 3578877776654444567899999999999 Q NP_000548.2 474 ISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 474 l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ++|||++++ .++++.++||+|++|||+ T Consensus 86 l~ily~~~~-~~~~~~~~~miv~~CgC~ 112 (112) T 1KTZ_A 86 LTILYYVGR-TPKVEQLSNMVVKSCKCS 112 (112) T ss_dssp EEEEEEETT-EEEEEEEEEEEECCEEEC T ss_pred eEEEEEeCC-eeEEEEecCeEEeeCcCC Confidence 999999987 577899999999999995 No 21 >5TY4_B TGF-beta receptor type-2 (E.C. 2.7.11.30); TRANSFERASE; 2.9A {Homo sapiens} Probab=99.80 E-value=9.9e-25 Score=179.89 Aligned_cols=96 Identities=34% Similarity=0.853 Sum_probs=84.4 Template_Neff=8.500 Q NP_000548.2 400 CSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILF 478 (501) Q Consensus 400 Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily 478 (501) ||+++++|+|+ ++||+ |||+|++|+++||.|.|..+... .++|+.++.+++...+.....|||+|++|++++|+| T Consensus 1 Cc~~~~~v~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~il~ 76 (97) T 5TY4_B 1 CCLRPLYIDFRKDLGWK-WIHEPKGYNANFCAGACPYLWSS---DTQHSRVLSLYNTINPEASASPCCVSQDLEPLTIVY 76 (97) T ss_pred CeEEEEEEECccccCCC-ceeCCCcccCeeeceeCCCCCCC---CccHHHHHHHHHhcCcccCCCCceeceeccceeEEE Confidence 89999999997 99998 99999999999999999988653 457888777765444445789999999999999999 Q NP_000548.2 479 IDSANNVVYKQYEDMVVESCGC 500 (501) Q Consensus 479 ~d~~~~~~~~~~~~mvv~~CgC 500 (501) ++++ +++++.++||+|++||| T Consensus 77 ~~~~-~~~~~~~~~m~v~~CgC 97 (97) T 5TY4_B 77 YVGR-KPKVEQLSNMIVKSCKC 97 (97) T ss_pred EeCC-ceEEEEecCeEEeeCCC Confidence 9987 57889999999999999 No 22 >5VT2_B Growth/differentiation factor 15; TGF-beta family, SIGNALING PROTEIN; HET: EDO; 2.3A {Homo sapiens} Probab=99.80 E-value=1.1e-24 Score=184.58 Aligned_cols=102 Identities=27% Similarity=0.753 Sum_probs=87.2 Template_Neff=8.300 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....|++++++|+|+||||++|||+|++|+++||.|.|..+... .++|+.++.+++...+.....|||+|++|++++ T Consensus 11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~ 87 (112) T 5VT2_B 11 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMV 87 (112) T ss_dssp TTCBSEEEEEEEEHHHHTCTTTEEECSEEEEEEEESBCCTTSSB---CSHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE T ss_pred CCCcceEEEEEEeHHHhCCCccEECCCeeeceeeeeeCCCCCCc---ccchHHHHHHHHhcCCCCCCCCceecceecceE Confidence 34455569999999999998899999999999999999998753 457888877765544556789999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|+++ +.+++++++||+|++|||. T Consensus 88 il~~~~-~~~~~~~~~~m~v~~C~C~ 112 (112) T 5VT2_B 88 LIQKTD-TGVSLQTYDDLLAKDCHCI 112 (112) T ss_dssp EEEECS-SSEEEEEEEEEEEEEEEEC T ss_pred EEEEcC-CeEEEEEeCCeEEecCCcC Confidence 999887 4788999999999999995 No 23 >5VZ3_A Growth/differentiation factor 15; Growth Factor, SIGNALING PROTEIN; 1.97A {Homo sapiens} Probab=99.80 E-value=1.1e-24 Score=184.58 Aligned_cols=102 Identities=27% Similarity=0.753 Sum_probs=87.2 Template_Neff=8.300 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....|++++++|+|+||||++|||+|++|+++||.|.|..+... .++|+.++.+++...+.....|||+|++|++++ T Consensus 11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~ 87 (112) T 5VZ3_A 11 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMV 87 (112) T ss_dssp SSSBSEEEEEEEEHHHHTCTTTEEECSEEEEEEEESBCCTTSSB---CSHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE T ss_pred CCCcceEEEEEEeHHHhCCCccEECCCeeeceeeeeeCCCCCCc---ccchHHHHHHHHhcCCCCCCCCceecceecceE Confidence 34455569999999999998899999999999999999998753 457888877765544556789999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|+++ +.+++++++||+|++|||. T Consensus 88 il~~~~-~~~~~~~~~~m~v~~C~C~ 112 (112) T 5VZ3_A 88 LIQKTD-TGVSLQTYDDLLAKDCHCI 112 (112) T ss_dssp EEEECS-SSEEEEEEEEEEEEEEEEC T ss_pred EEEEcC-CeEEEEEeCCeEEecCCcC Confidence 999887 4788999999999999995 No 24 >2ARP_A Inhibin beta A chain, Follistatin; cystine knot, disulfide rich, egf; HET: GOL, 1PG; 2.0A {Homo sapiens} SCOP: g.17.1.2 Probab=99.79 E-value=1.3e-24 Score=184.92 Aligned_cols=105 Identities=38% Similarity=0.831 Sum_probs=81.5 Template_Neff=8.700 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL--EPTNHAVIQTLMNS--MDPESTPPTCCVPTRLS 472 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~--~~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~ 472 (501) ...||++.++|+|++|||++|||+|++|+++||.|.|..+..... ..++|+.++.++.. ..+.....|||+|++|+ T Consensus 8 ~~~C~~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~~~CC~P~~~~ 87 (116) T 2ARP_A 8 VNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLR 87 (116) T ss_dssp -CCSEEECCEEEHHHHTCTTTEEECSEEECCEEESCCCC-CCHHH----H----HHHHTTSTTCSSCCCCCCCEEEEEEE T ss_pred cccceeEEEEEeHHHcCCccceeCCCceeCceeeeeCCCCcCcCCCCCcchHHHHHHHHHhhCCCCCcCCCCcccccccC Confidence 678999999999999999889999999999999999998865321 12456655554321 12335679999999999 Q NP_000548.2 473 PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +++|+|++++++++++.++||+|++|||+ T Consensus 88 ~l~il~~~~~~~~~~~~~~~m~v~~CgC~ 116 (116) T 2ARP_A 88 PMSMLYYDDGQNIIKKDIQNMIVEECGCS 116 (116) T ss_dssp EEEEEEEC-TTCEEEEEEEEEEEEEEEEC T ss_pred ceEEEEEcCCCcEEEEEeCCeEEeecccC Confidence 99999999877788999999999999995 No 25 >2ARV_A Inhibin beta A chain; homodimer, cystine knot, disulfide linked; HET: 1PG, SO4, GOL; 2.0A {Homo sapiens} SCOP: g.17.1.2 Probab=99.79 E-value=1.3e-24 Score=184.92 Aligned_cols=105 Identities=38% Similarity=0.831 Sum_probs=86.7 Template_Neff=8.700 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL--EPTNHAVIQTLMNS--MDPESTPPTCCVPTRLS 472 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~--~~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~ 472 (501) ...||++.++|+|++|||++|||+|++|+++||.|.|+.+..... +.++|+.++.++.. ..+.....|||+|++|+ T Consensus 8 ~~~C~~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~~~CC~P~~~~ 87 (116) T 2ARV_A 8 VNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLR 87 (116) T ss_dssp CCBSEEECCEEETTTTTCTTTEEECSEEECCEEESBCCGGGTTEETTEECHHHHHHHHHHHTTCTTTTTSCCCEEEEEEE T ss_pred cccceeEEEEEeHHHcCCccceeCCCeEeCeeeEEECCCCCCCCCCCCcchHHHHHHHHHhcCCCCccCCCCccccceec Confidence 678999999999999999889999999999999999998865321 12456655554321 12335679999999999 Q NP_000548.2 473 PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +++|||++++++++++.++||+|++|||+ T Consensus 88 ~l~il~~~~~~~~~~~~~~~m~v~~CgC~ 116 (116) T 2ARV_A 88 PMSMLYYDDGQNIIKKDIQNMIVEECGCS 116 (116) T ss_dssp EEEEEEEETTTEEEEEEEEEEEEEEEEEC T ss_pred cEEEEEEeCCCeEEEEEeCCeEEeeccCC Confidence 99999999877788999999999999995 No 26 >2P6A_B Activin A, Follistatin 315; Follistatin, Activin,Inhibin, TGF-beta, SIGNALING PROTEIN; 3.4A {Homo sapiens} SCOP: g.17.1.2 Probab=99.79 E-value=1.3e-24 Score=184.92 Aligned_cols=105 Identities=38% Similarity=0.831 Sum_probs=86.7 Template_Neff=8.700 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL--EPTNHAVIQTLMNS--MDPESTPPTCCVPTRLS 472 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~--~~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~ 472 (501) ...||++.++|+|++|||++|||+|++|+++||.|.|+.+..... +.++|+.++.++.. ..+.....|||+|++|+ T Consensus 8 ~~~C~~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~~~CC~P~~~~ 87 (116) T 2P6A_B 8 VNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLR 87 (116) T ss_pred cccceeEEEEEeHHHcCCccceeCCCeEeCeeeEEECCCCCCCCCCCCcchHHHHHHHHHhcCCCCccCCCCccccceec Confidence 678999999999999999889999999999999999998865321 12456655554321 12335679999999999 Q NP_000548.2 473 PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +++|||++++++++++.++||+|++|||+ T Consensus 88 ~l~il~~~~~~~~~~~~~~~m~v~~CgC~ 116 (116) T 2P6A_B 88 PMSMLYYDDGQNIIKKDIQNMIVEECGCS 116 (116) T ss_pred cEEEEEEeCCCeEEEEEeCCeEEeeccCC Confidence 99999999877788999999999999995 No 27 >2TGI_A TRANSFORMING GROWTH FACTOR-BETA TWO (TGF-B2); GROWTH FACTOR; 1.8A {Homo sapiens} SCOP: g.17.1.2 Probab=99.79 E-value=1.5e-24 Score=183.69 Aligned_cols=101 Identities=35% Similarity=0.828 Sum_probs=88.1 Template_Neff=8.200 Q NP_000548.2 396 LKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI 474 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l 474 (501) ....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+... .++|+.++.+++...+.....|||+|++|+++ T Consensus 11 ~~~~Cc~~~~~V~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l 86 (112) T 2TGI_A 11 VQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYLWSS---DTQHSRVLSLYNTINPEASASPCCVSQDLEPL 86 (112) T ss_dssp CCSBSEEECCEEECCCCCCCT-TEEECSEEECCEEECBCCTTSSB---CSHHHHHHHHHHHHCGGGCCCCCEEECSEEEE T ss_pred CCCCcEEEEEEEECchhhCCc-eeeCCCeEeceeecccCCCCCCC---cccHHHHHHHHHhcCcccCCCCceeceeecce Confidence 478999999999999 99998 99999999999999999988653 34677777766544444678999999999999 Q NP_000548.2 475 SILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 475 ~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +|||++++ +++++.++||+|++|||+ T Consensus 87 ~il~~~~~-~~~~~~~~~m~v~~CgC~ 112 (112) T 2TGI_A 87 TILYYIGK-TPKIEQLSNMIVKSCKCS 112 (112) T ss_dssp EEEEEETT-EEEEEEEEEEEECCEEEC T ss_pred EEEEEeCC-ceEEEEeCCeEEEeCCCC Confidence 99999986 578899999999999995 No 28 >3HH2_B Growth/differentiation factor 8, Follistatin; protein-protein complex, TB domain, cystine; HET: PO4, CIT; 2.15A {Mus musculus} Probab=99.79 E-value=2.4e-24 Score=181.50 Aligned_cols=99 Identities=39% Similarity=0.949 Sum_probs=82.7 Template_Neff=8.200 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|++|||+ |||+|++|+++||.|.|..+.... .+|+. +++...+.....|||+|++|++++ T Consensus 11 ~~~~C~~~~~~V~f~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~~---~~~~~---l~~~~~~~~~~~~CC~P~~~~~l~ 83 (109) T 3HH2_B 11 TESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQK---YPHTH---LVHQANPRGSAGPCCTPTKMSPIN 83 (109) T ss_dssp CCCBSEEECCEEEHHHHTCT-TEEECSEEECCEEECBCCTTTTBC---CHHHH---HHHHHCCTTCCCCCEEEEEEEEEE T ss_pred CCCceeeeEEEEehHHhCCc-eEECCCeeeceEeceeCCCccccc---CCcce---ehhhcCCCCCCCCCccceeeCCeE Confidence 46799999999999999998 999999999999999999987542 13332 222222235689999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|++++++++++.++||+|++|||+ T Consensus 84 il~~~~~~~~~~~~~~~m~v~~CgC~ 109 (109) T 3HH2_B 84 MLYFNGKEQIIYGKIPAMVVDRCGCS 109 (109) T ss_dssp EEEECTTCCEEEEEEEEEEEEEEEEC T ss_pred EEEEcCCCeEEEEEeCCeEEecccCC Confidence 99999877788999999999999995 No 29 >5F3B_C RK35 Chimeric antibody heavy chain; myostatin, antibody, complex, Signaling Protein-Immune; HET: GOL; 1.76A {Mus musculus} Probab=99.79 E-value=2.4e-24 Score=181.50 Aligned_cols=99 Identities=39% Similarity=0.949 Sum_probs=82.7 Template_Neff=8.200 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|++|||+ |||+|++|+++||.|.|..+.... .+|+. +++...+.....|||+|++|++++ T Consensus 11 ~~~~C~~~~~~V~f~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~~---~~~~~---l~~~~~~~~~~~~CC~P~~~~~l~ 83 (109) T 5F3B_C 11 TESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQK---YPHTH---LVHQANPRGSAGPCCTPTKMSPIN 83 (109) T ss_pred CCCceeeeEEEEehHHhCCc-eEECCCeeeceEeceeCCCccccc---CCcce---ehhhcCCCCCCCCCccceeeCCeE Confidence 46799999999999999998 999999999999999999987542 13332 222222235689999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|++++++++++.++||+|++|||+ T Consensus 84 il~~~~~~~~~~~~~~~m~v~~CgC~ 109 (109) T 5F3B_C 84 MLYFNGKEQIIYGKIPAMVVDRCGCS 109 (109) T ss_pred EEEEcCCCeEEEEEeCCeEEecccCC Confidence 99999877788999999999999995 No 30 >3KFD_D Transforming growth factor beta-1, TGF-beta; TGF-beta, TGF-b1, TGF-beta receptor type-1; 2.995A {Homo sapiens} Probab=99.78 E-value=3.7e-24 Score=181.25 Aligned_cols=102 Identities=30% Similarity=0.731 Sum_probs=87.9 Template_Neff=8.300 Q NP_000548.2 395 NLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSP 473 (501) Q Consensus 395 ~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~ 473 (501) .....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+... .++|+.++.+++...+..+..|||+|++|++ T Consensus 10 ~~~~~C~~~~~~v~f~~~lg~~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~~~~~~~~~~~~~~~~~~~~CC~P~~~~~ 85 (112) T 3KFD_D 10 STEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIWSL---DTQYSKVLALYNQHNPGASAAPCCVPQALEP 85 (112) T ss_pred CCCCCcEEEEEEEECccccCCc-eeeCCCeEEeeeeceeCCCCCCC---cccHHHHHHHHHhhCCCCCCCCccccccccc Confidence 3477899999999998 99998 99999999999999999988653 3467777766654444467899999999999 Q NP_000548.2 474 ISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 474 l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ++|+|++++ +++++.++||+|++|||+ T Consensus 86 l~ily~~~~-~~~~~~~~~m~v~~CgC~ 112 (112) T 3KFD_D 86 LPIVYYVGR-KPKVEQLSNMIVRSCKCS 112 (112) T ss_pred eeEEEEeCC-eEEEEEeCCeEEEecCCC Confidence 999999987 577899999999999995 No 31 >5E4G_A Growth/differentiation factor 11; Bone morphogenetic protein 11, BMP-11; HET: PG4; 1.5A {Homo sapiens} Probab=99.76 E-value=1.2e-23 Score=177.01 Aligned_cols=99 Identities=37% Similarity=0.939 Sum_probs=83.0 Template_Neff=8.400 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|+||||+ |||+|++|+++||.|+|..+.... .+|+.+ +....+..++.|||+|++|++++ T Consensus 11 ~~~~C~~~~~~V~f~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~~---~~~~~l---~~~~~~~~~~~~cC~P~~~~~l~ 83 (109) T 5E4G_A 11 SESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQK---YPHTHL---VQQANPRGSAGPCCTPTKMSPIN 83 (109) T ss_dssp CCCBSEEECCEEETTTTTCT-TEEECSEEECCEEECBCCTTTTCS---STHHHH---HHHHCCTTCCCCCEEEEEEEEEE T ss_pred CcCceEeEEEEEehHHcCCc-eEeCCCeeeceeecccCCcccccc---CCchHH---HHhcCCCCCCCCCccceeeccEE Confidence 47799999999999999998 999999999999999999987532 133322 11122345789999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|++++++++++.++||+|++|||+ T Consensus 84 il~~~~~~~~~~~~~~d~~v~~C~C~ 109 (109) T 5E4G_A 84 MLYFNDKQQIIYGKIPGMVVDRCGCS 109 (109) T ss_dssp EEEECSSSCEEEEEEEEEEEEEEEEC T ss_pred EEEEcCCCeEEEEEeCCeEEeeccCC Confidence 99999887888999999999999995 No 32 >5NMZ_B Neurturin; cystine knot, neurotrophic factor, GFL; HET: GOL; 1.6A {Homo sapiens} Probab=99.71 E-value=2.2e-22 Score=166.98 Aligned_cols=93 Identities=22% Similarity=0.465 Sum_probs=76.9 Template_Neff=8.300 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD---PESTPPTCCVPTRLS 472 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~---~~~~~~pCC~P~~~~ 472 (501) ...||+++++|+|+||||+ | |+|++|+++||.|.|..+.. +| +.++.+++... +.....|||+|++|+ T Consensus 4 ~~~C~~~~~~v~f~dlgw~-~-i~P~~~~~~~C~G~C~~~~~------~~~~~~~~l~~~~~~~~~~~~~~~CC~P~~~~ 75 (101) T 5NMZ_B 4 ARPCGLRELEVRVSELGLG-Y-ASDETVLFRYCAGACEAAAR------VYDLGLRRLRQRRRLRRERVRAQPCCRPTAYE 75 (101) T ss_dssp CCBSEEEEEEEEGGGGTSS-C-CCCCEEEEEEEECBCGGGCC------HHHHHHHHHHTTTCSTTCCBCCSCCEEEEEEC T ss_pred CCCccceEEEEeHHHcCCe-e-ecCCeEECeeeceeCCchhh------chHHHHHHHHHhhhhhccccCCCCceeeeeec Confidence 5689999999999999999 8 89999999999999999864 23 33444433322 246789999999999 Q NP_000548.2 473 -PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 473 -~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +++ |+|++ ++++.++||+|++|||+ T Consensus 76 ~~l~--y~d~~--~~~~~~~~m~v~~CgC~ 101 (101) T 5NMZ_B 76 DEVS--FLDAH--SRYHTVHELSARECACV 101 (101) T ss_dssp SEEE--EECTT--CCEEEEESCSEEEEEEC T ss_pred CceE--eecCC--cEEEEeCCeeeecccCC Confidence 999 77764 78899999999999995 No 33 >5NMZ_C Neurturin; cystine knot, neurotrophic factor, GFL; HET: GOL; 1.6A {Homo sapiens} Probab=99.71 E-value=2.2e-22 Score=166.98 Aligned_cols=93 Identities=22% Similarity=0.465 Sum_probs=76.9 Template_Neff=8.300 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD---PESTPPTCCVPTRLS 472 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~---~~~~~~pCC~P~~~~ 472 (501) ...||+++++|+|+||||+ | |+|++|+++||.|.|..+.. +| +.++.+++... +.....|||+|++|+ T Consensus 4 ~~~C~~~~~~v~f~dlgw~-~-i~P~~~~~~~C~G~C~~~~~------~~~~~~~~l~~~~~~~~~~~~~~~CC~P~~~~ 75 (101) T 5NMZ_C 4 ARPCGLRELEVRVSELGLG-Y-ASDETVLFRYCAGACEAAAR------VYDLGLRRLRQRRRLRRERVRAQPCCRPTAYE 75 (101) T ss_dssp CCBSEEEEEEEEGGGGTSS-S-CCCCEEEEEEEECBCCTTSC------HHHHHHHHHHHTTCSTTCCCCCSCCEEEEEEC T ss_pred CCCccceEEEEeHHHcCCe-e-ecCCeEECeeeceeCCchhh------chHHHHHHHHHhhhhhccccCCCCceeeeeec Confidence 5689999999999999999 8 89999999999999999864 23 33444433322 246789999999999 Q NP_000548.2 473 -PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 473 -~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +++ |+|++ ++++.++||+|++|||+ T Consensus 76 ~~l~--y~d~~--~~~~~~~~m~v~~CgC~ 101 (101) T 5NMZ_C 76 DEVS--FLDAH--SRYHTVHELSARECACV 101 (101) T ss_dssp SCEE--EECTT--SCEEEESSCSEEEEEEC T ss_pred CceE--eecCC--cEEEEeCCeeeecccCC Confidence 999 77764 78899999999999995 No 34 >2GH0_C artemin, GDNF family receptor alpha-3; cystine-knot, helix bundle, HORMONE-GROWTH FACTOR; HET: BMA, NAG, MAN; 1.92A {Homo sapiens} Probab=99.71 E-value=2.9e-22 Score=166.00 Aligned_cols=95 Identities=19% Similarity=0.418 Sum_probs=77.9 Template_Neff=8.600 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMD----PESTPPTCCVPTRLSP 473 (501) Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~----~~~~~~pCC~P~~~~~ 473 (501) ..||+++++|+|+||||++||| ++|+++||.|.|+.+.... .+.|+.++.++ ... ....+.|||+|++|++ T Consensus 2 ~~C~~~~~~V~f~dlgw~~~I~--~~~~~~~C~G~C~~~~~~~--~~~~~~l~~~~-~~~~~~~~~~~~~~CC~P~~~~~ 76 (101) T 2GH0_C 2 PGCRLRSQLVPVRALGLGHRSD--ELVRFRFCSGSCRRARSPH--DLSLASLLGAG-ALRPPPGSRPVSQPCCRPTRYEA 76 (101) T ss_pred CCCcceEEEEeHHHcCCCcccC--cEEecceeeeeCCCCCCCc--cchHHHHHHcc-cCCCCCCCCCCCCCceeeeeecc Confidence 4799999999999999988988 9999999999999987642 23455554443 111 1357899999999999 Q NP_000548.2 474 ISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 474 l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ++|||+++ +++.++||+|++|||+ T Consensus 77 l~il~~~~----~~~~~~~m~v~~CgC~ 100 (101) T 2GH0_C 77 VSFMDVNS----TWRTVDRLSATACGCL 100 (101) T ss_pred eEEEEeCC----eeEEEcceEeeccccc Confidence 99999875 5789999999999995 No 35 >5MR4_B Neurturin, GDNF family receptor alpha-2; Complex, Signalling, Receptor, signaling protein; 2.4A {Homo sapiens} Probab=99.70 E-value=4.4e-22 Score=165.39 Aligned_cols=94 Identities=21% Similarity=0.445 Sum_probs=76.5 Template_Neff=8.200 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD---PESTPPTCCVPTRL 471 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~---~~~~~~pCC~P~~~ 471 (501) ....||+++++|+|+||||+ | |+|++|+++||.|.|+.+.. +| +.++.++.... +.....|||+|++| T Consensus 4 ~~~~C~~~~~~v~f~dlgw~-~-i~P~~~~~~~C~G~C~~~~~------~~~~~~~~~~~~~~~~~~~~~~~~CC~P~~~ 75 (102) T 5MR4_B 4 GARPCGLRELEVRVSELGLG-Y-ASDETVLFRYCAGACEAAAR------VYDLGLRRLRQRRRLRRERVRAQPCCRPTAY 75 (102) T ss_dssp -CCBSEEEEEEEEGGGGSSS-C-CCCCEEEEEEEESBCCSCCC------HHHHHHHHHHHTTCSTTCCCCCSCCEEEEEE T ss_pred CCCCceeeEEEEEHHHcCCc-e-eCCCeEECeeeceeCCchhc------chHHHHHHHHHhhhhhccccCCCCceeeeee Confidence 35789999999999999998 7 89999999999999999864 23 33333333222 24678999999999 Q NP_000548.2 472 S-PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 472 ~-~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) + +++ |+|++ ++++.++||+|++|||+ T Consensus 76 ~~~l~--y~d~~--~~~~~~~~m~v~~CgC~ 102 (102) T 5MR4_B 76 EDEVS--FLDAH--SRYHTVHELSARECACV 102 (102) T ss_dssp CCEEE--EECTT--SCEEEEESCSEEEEEEC T ss_pred cCceE--eecCC--cEEEEECCeeeccccCC Confidence 9 999 77764 78999999999999995 No 36 >2V5E_B GDNF FAMILY RECEPTOR ALPHA-1, GLIAL; RECEPTOR-GLYCOPROTEIN COMPLEX, CELL MEMBRANE, GROWTH; HET: NAG, EDO, SCR; 2.35A {RATTUS NORVEGICUS} Probab=99.69 E-value=7.4e-22 Score=163.65 Aligned_cols=93 Identities=24% Similarity=0.547 Sum_probs=77.2 Template_Neff=8.400 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD--PESTPPTCCVPTRLS- 472 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~--~~~~~~pCC~P~~~~- 472 (501) ...||+++++|+|+||||+ | |+|++|+++||.|.|+.+.. +| +.++.+++... +..+..|||+|++|+ T Consensus 5 ~~~C~~~~~~V~f~~lgw~-~-i~P~~~~~~~C~G~C~~~~~------~h~~~~~~l~~~~~~~~~~~~~~CC~P~~~~~ 76 (101) T 2V5E_B 5 NRGCVLTAIHLNVTDLGLG-Y-ETKEELIFRYCSGSCDAAET------TYDKILKNLSRNRRLVSDKVGQACCRPIAFDD 76 (101) T ss_dssp TTTCEEEEEEEEGGGGCSS-C-CCSCEEEEEEEESCCCSCCS------HHHHHHHHHHHTTSSSSSSTTCCCEEEEEECC T ss_pred CCcceeeEEEEEHHHcCCc-c-cCCCeEECceecEeCCCCCC------cHHHHHHHHHhccCCCcccCCCCeEEeeEecC Confidence 5689999999999999998 7 89999999999999999842 45 44554443321 345789999999999 Q NP_000548.2 473 PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +++ |+|++ ++++.++||+|++|||+ T Consensus 77 ~l~--y~d~~--~~~~~~~~m~v~~CgC~ 101 (101) T 2V5E_B 77 DLS--FLDDN--LVYHILRKHSAKRCGCI 101 (101) T ss_dssp CEE--EECTT--SCEEEECSCSEEEEEEC T ss_pred ceE--EecCC--EEEEEecCcEecccccC Confidence 999 77775 57899999999999995 No 37 >2ASK_B artemin; Glial cell derived family ligand; HET: SO4; 1.55A {Homo sapiens} Probab=99.69 E-value=9.1e-22 Score=166.60 Aligned_cols=94 Identities=20% Similarity=0.467 Sum_probs=77.2 Template_Neff=8.000 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD------PESTPPTCCVP 468 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~------~~~~~~pCC~P 468 (501) ....||+++++|+|+||||+ | |+|++|+++||.|.|..+. ++| +.++.+++... ......|||+| T Consensus 12 ~~~~Cc~~~~~V~F~dlgw~-~-i~P~~~~~~~C~G~C~~~~------~~h~~~~~~l~~~~~~~~~~~~~~~~~~CC~P 83 (113) T 2ASK_B 12 GARGCRLRSQLVPVRALGLG-H-RSDELVRFRFCSGSCRRAR------SPHDLSLASLLGAGALRPPPGSRPVSQPCCRP 83 (113) T ss_dssp -CCBSEEEEEEEEGGGGSSS-C-CBSSEEEEEEEECBCGGGC------CHHHHHHHHHHHTTCSCCCSSSCCCCSCEEEE T ss_pred CCCCceeEEEEEEHHHcCCC-c-cCCCeEECceEeeeCCCCC------CCcHHHHHHHHHccCCCCCCCCCCCCCCceee Confidence 46799999999999999998 6 7999999999999999983 245 45555554332 23578999999 Q NP_000548.2 469 TRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 469 ~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ++|++++ |+|++ +++++++||+|++|||. T Consensus 84 ~~~~~l~--y~d~~--~~~~~l~~miv~~CgC~ 112 (113) T 2ASK_B 84 TRYEAVS--FMDVN--STWRTVDRLSATACGCL 112 (113) T ss_dssp EEEEEEE--EEBTT--SCEEEEEEEEEEEEEEE T ss_pred eEeceee--eecCC--cEEEEECCeEEeccccc Confidence 9999877 77775 67899999999999995 No 38 >3FUB_D GDNF family receptor alpha-1, Glial; GFRALPHA1, ALL ALPHA GDNF, CYSTINE; HET: NAG, EDO; 2.35A {Rattus norvegicus} Probab=99.69 E-value=9.6e-22 Score=171.18 Aligned_cols=96 Identities=24% Similarity=0.517 Sum_probs=80.0 Template_Neff=6.800 Q NP_000548.2 394 KNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSM--DPESTPPTCCVPTR 470 (501) Q Consensus 394 ~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~--~~~~~~~pCC~P~~ 470 (501) ......||++.++|+|+||||+ | |+|++|+++||.|.|.++. ++| ++++.+++.. .+..+..|||+|++ T Consensus 35 ~~~~~~Ccr~~l~V~F~dlGw~-~-iaP~~f~~~~C~G~C~~~~------t~h~~~l~~l~~~~~~~~~~~~~pCCvP~~ 106 (134) T 3FUB_D 35 RGKNRGCVLTAIHLNVTDLGLG-Y-ETKEELIFRYCSGSCDAAE------TTYDKILKNLSRNRRLVSDKVGQACCRPIA 106 (134) T ss_pred CCCCCcceEEEEEEeHHHcCCC-c-cCCCeEEeEEeeCCCCCCc------chHHHHHHHHHHcCCCCCCCCCCCeeeeeE Confidence 3457899999999999999998 6 5999999999999999982 356 5666665543 12357899999999 Q NP_000548.2 471 LS-PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 471 ~~-~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+ +++ |++++ + ++++++||+|++|||. T Consensus 107 ~~~~l~--y~d~~-~-~~~~l~~mvv~~CgC~ 134 (134) T 3FUB_D 107 FDDDLS--FLDDN-L-VYHILRKHSAKRCGCI 134 (134) T ss_pred eCCcee--EECCC-c-eEEEEcCeEEecccCC Confidence 99 988 77776 4 7899999999999995 No 39 >1AGQ_C GLIAL CELL-DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR, NEUROTROPHIC FACTOR, CYSTINE; 1.9A {Rattus norvegicus} SCOP: g.17.1.2 Probab=99.67 E-value=2.2e-21 Score=169.01 Aligned_cols=95 Identities=26% Similarity=0.544 Sum_probs=76.0 Template_Neff=6.700 Q NP_000548.2 395 NLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD--PESTPPTCCVPTRL 471 (501) Q Consensus 395 ~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~--~~~~~~pCC~P~~~ 471 (501) .....||++.++|+|+||||+ | |+|.+|+++||.|.|.++. ++| ++++.+++... +..+..|||+|++| T Consensus 37 ~~~~~Cc~~~l~V~F~dlGW~-i-iaP~~~~~~~C~G~C~~~~------t~h~~~l~~l~~~~~~~~~~~~~pCCvP~~~ 108 (135) T 1AGQ_C 37 GKNRGCVLTAIHLNVTDLGLG-Y-ETKEELIFRYCSGSCEAAE------TMYDKILKNLSRSRRLTSDKVGQACCRPVAF 108 (135) T ss_dssp ----CCEEEEEEEEGGGGCSC-C-CCCCEEEEEEEESCCCCCC------SHHHHHHHHHHHTTCC----CCCCCEEEEEE T ss_pred CCCCCceEEEEEEEHHHcCCC-c-cCCCeEEeEEecCCCCCCc------chHHHHHHHHHhhcCCCCcccCCCeeeeeee Confidence 457899999999999999998 5 8999999999999999972 367 66666655432 33578999999999 Q NP_000548.2 472 S-PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 472 ~-~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) + +++ |++++ +++++++||+|++|||. T Consensus 109 ~~~l~--y~d~~--~~~~~l~dmiv~~CgC~ 135 (135) T 1AGQ_C 109 DDDLS--FLDDS--LVYHILRKHSAKRCGCI 135 (135) T ss_dssp CCCEE--EECSS--SCEEEECSCSEEEEEEC T ss_pred cCCee--eecCC--eEEEEEcCeEEecccCC Confidence 9 999 77765 47899999999999995 No 40 >5TX2_A Transforming growth factor beta-2; Growth factor, CYTOKINE; 1.82A {Mus musculus} Probab=99.66 E-value=2.9e-21 Score=157.69 Aligned_cols=81 Identities=33% Similarity=0.827 Sum_probs=74.0 Template_Neff=7.400 Q NP_000548.2 396 LKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI 474 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l 474 (501) ....||+++++|+|+ ||||+ |||+|++|+++||.|.|..+. .+.+||+|++|+++ T Consensus 12 ~~~~C~~~~~~v~f~~dlgw~-~Ii~P~~~~~~~C~G~C~~~~-----------------------~~~~CC~P~~~~~l 67 (93) T 5TX2_A 12 VQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYRA-----------------------SKSPSCVSQDLEPL 67 (93) T ss_dssp CCSBSEEECCEEEHHHHHCCC-SEEECSEEECCEEECBCCCCS-----------------------SSCCCEEECCEEEE T ss_pred CCCCcEEEEEEEECchhcCCC-cEeCCCeEEcEEecccCCCCC-----------------------CCCCCceeceecce Confidence 478999999999999 99998 999999999999999998751 25799999999999 Q NP_000548.2 475 SILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 475 ~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +|||++++ +++++.++||+|++|||+ T Consensus 68 ~il~~~~~-~~~~~~l~~~~v~~CgC~ 93 (93) T 5TX2_A 68 TILYYIGN-TPKIEQLSNMIVKSCKCS 93 (93) T ss_dssp EEEEEETT-EEEEEEEEEEEECEEEEC T ss_pred EEEEEeCC-eEEEEEEcCcEEecCccC Confidence 99999986 578999999999999995 No 41 >5TX4_B TGF-beta receptor type-2 (E.C.2.7.11.30), Transforming; TGF-beta, TGF-beta type II receptor; 1.876A {Homo sapiens} Probab=99.66 E-value=3e-21 Score=157.29 Aligned_cols=81 Identities=31% Similarity=0.818 Sum_probs=74.3 Template_Neff=7.500 Q NP_000548.2 396 LKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI 474 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l 474 (501) ....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+. .+.|||+|++|+++ T Consensus 11 ~~~~C~~~~~~v~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~-----------------------~~~~CC~P~~~~~~ 66 (92) T 5TX4_B 11 VQDNCCLRPLYIDFRKDLGWK-WIHEPKGYNANFCAGACPYRA-----------------------SKSPSCVSQDLEPL 66 (92) T ss_pred CCCCcEEEEEEEECchhcCCC-ceeCCCeEEcEEeeccCCCCC-----------------------CCCCceeccccCce Confidence 467999999999998 99998 999999999999999998752 25799999999999 Q NP_000548.2 475 SILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 475 ~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +|||++++ +++++.++||+|++|+|+ T Consensus 67 ~il~~~~~-~i~~~~~~~~~v~~C~C~ 92 (92) T 5TX4_B 67 TIVYYVGR-KPKVEQLSNMIVKSCKCS 92 (92) T ss_pred eEEEEeCC-eeEEEEEcCeEEecCCCC Confidence 99999987 678999999999999995 No 42 >2GYZ_A neurotrophic factor artemin isoform 3; neurotrophic factor, cystine-knot, HORMONE-GROWTH FACTOR; 1.76A {Homo sapiens} Probab=99.57 E-value=1.4e-19 Score=150.88 Aligned_cols=89 Identities=18% Similarity=0.342 Sum_probs=71.6 Template_Neff=7.300 Q NP_000548.2 399 RCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD------PESTPPTCCVPTRL 471 (501) Q Consensus 399 ~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~------~~~~~~pCC~P~~~ 471 (501) .||+++++|+|+||||+ ||+|++|+++||.|+|..+.. ++ +.++.++.... +.....|||+|++| T Consensus 1 ~Cc~~~l~V~F~dlGw~--IiaP~~~~a~yC~G~C~~~~~------~~~~~~~~l~~~~~~~~~~~~~~~~~pCC~P~~~ 72 (105) T 2GYZ_A 1 GCRLRSQLVPVRALGLG--HRSDELVRFRFCSGSCRRARS------PHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRY 72 (105) T ss_dssp CCEEEEEEEEGGGGSSS--CCCSSEEEEEEEESCCGGGCC------HHHHHHHHHHHTTCSCCCSSSCCCSSCCCEEEEE T ss_pred CCeeEEEEEeHHHcCCc--cccCCceeceEEeccCCCCCC------chHHHHHHHHHhcCCCCCCCCCCCCCCeeeeeee Confidence 49999999999999998 899999999999999999853 22 23323332221 24578999999999 Q NP_000548.2 472 SPISILFIDSA-NNVVYKQYEDMVVES 497 (501) Q Consensus 472 ~~l~ily~d~~-~~~~~~~~~~mvv~~ 497 (501) ++++ |+|++ +.+++++++||+|.. T Consensus 73 ~~l~--y~d~~~~~i~~~~lp~m~~~~ 97 (105) T 2GYZ_A 73 EAVS--FMDVNSTWRTVDRLSATACGC 97 (105) T ss_dssp EEEE--EECTTSCEEEEEEEEEEEEEC T ss_pred ceee--EEeCCCCeEEEEEeccceeec Confidence 9999 88876 578899999999875 No 43 >6Q2S_B Ubiquitin-like protein SMT3,Artemin, GDNF family; RET, receptor tyrosine kinase, cryo-EM; HET: NAG; 3.8A {Saccharomyces cerevisiae} Probab=99.47 E-value=2.9e-18 Score=163.18 Aligned_cols=93 Identities=20% Similarity=0.483 Sum_probs=77.2 Template_Neff=8.400 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD------PESTPPTCCVPT 469 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~------~~~~~~pCC~P~ 469 (501) ...||++.++|+|++|||+ ||+|.+|+++||.|.|..+. ++| +.++.+++... ......|||+|+ T Consensus 135 ~~~C~~~~~~V~f~~lgw~--ii~P~~~~~~~C~G~C~~~~------~~~~~~~~~l~~~~~~~~~~~~~~~~~~CC~P~ 206 (235) T 6Q2S_B 135 ARGCRLRSQLVPVRALGLG--HRSDELVRFRFCSGSCRRAR------SPHDLSLASLLGAGALRPPPGSRPVSQPCCRPT 206 (235) T ss_pred CceeeeecCccchHHcCCe--eecCCeEECccccCCCCCCC------CCHHHHHHHHHHcCCCCCCCCCCCCCCCccCce Confidence 5789999999999999998 58999999999999999983 255 45555554332 135789999999 Q NP_000548.2 470 RLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 470 ~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +|++++ |++++ +++++++||+|++|||+ T Consensus 207 ~~~~l~--y~~~~--~~~~~~~~m~v~~CgC~ 234 (235) T 6Q2S_B 207 RYEAVS--FMDVN--STWRTVDRLSATACGCL 234 (235) T ss_pred ecCeee--eecCC--eEEEEeCCcEEeccccc Confidence 999988 77764 67899999999999995 No 44 >6GFF_E Transforming growth factor beta-1, Leucine-rich; GARP, TGF-B1, Activation, Treg, IMMUNE; HET: BMA, MAN, NAG; 3.1A {Mus musculus} Probab=98.95 E-value=1.1e-13 Score=131.10 Aligned_cols=158 Identities=22% Similarity=0.234 Sum_probs=101.3 Template_Neff=9.700 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGN------SSVKLEAGLANTITSFIDKGQDDRG-P 215 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~------~~~~~~~~~~n~Vrsf~~~~~~~~~-~ 215 (501) .+||++|||+++|+++.. .+.+++++|++||+.+......... ..+.+....+++|++|......... . T Consensus 22 ~~IL~~Lgl~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~s~~~~~~~~~~~~ 97 (249) T 6GFF_E 22 GQILSKLRLASPPSQGEV----PPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQ 97 (249) T ss_pred HHHHHHcCCCCCCCCCCC----CCCCccHHHHHHHHhhhccccCCCCCcccCCcccchhcccceeeeecCCCCCCCcccC Confidence 689999999999998651 1245689999999987665321100 0111223456788888654332100 1 Q NP_000548.2 216 VVRKQRYVFDISALE----K-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG 290 (501) Q Consensus 216 ~~~~~~l~FnlSsi~----~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g 290 (501) ......+.|++++++ . +.|.+|+||||+..... ...|.||...... ...++..+.+.....++ T Consensus 98 ~~~~~~l~F~ls~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~~-~~~~l~~~~v~~~~~~~ 165 (249) T 6GFF_E 98 STHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSNN-SWRYLSNRLLAPSDSPE 165 (249) T ss_pred CCCcEEEEEecccCCCCCCCccceEEEEEEEEeCCCCC-----------cEEEEEEEecCCC-ceeEEEEEEeecCCCCc Confidence 234677999999742 2 47999999999987642 3566777643210 11123333221234579 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA--QLCLELEAW 316 (501) Q Consensus 291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~ 316 (501) |+.||||.+|+.|+.++ +++|.|.+. T Consensus 166 W~~~dvt~~v~~W~~~~~~n~gl~v~v~ 193 (249) T 6GFF_E 166 WLSFDVTGVVRQWLSRGGEIEGFRLSAH 193 (249) T ss_pred eEEEEcHHHHHHHHhCCcccceEEEEEE Confidence 99999999999999986 788886554 No 45 >6GFF_G Transforming growth factor beta-1, Leucine-rich; GARP, TGF-B1, Activation, Treg, IMMUNE; HET: MAN, NAG, BMA; 3.1A {Mus musculus} Probab=98.95 E-value=1.1e-13 Score=131.18 Aligned_cols=158 Identities=22% Similarity=0.234 Sum_probs=101.5 Template_Neff=9.600 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGN------SSVKLEAGLANTITSFIDKGQDDRG-P 215 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~------~~~~~~~~~~n~Vrsf~~~~~~~~~-~ 215 (501) .+||++|||+++|++... .+.+++++|++||+.+......... ..+.+....+++|++|......... . T Consensus 22 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~s~~~~~~~~~~~~ 97 (249) T 6GFF_G 22 GQILSKLRLASPPSQGEV----PPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQ 97 (249) T ss_dssp HHHHHHTTCSSCCCSTTC----CSSSCCHHHHHHHHHHHSCCCCC-------CGGGTSCEEEEEEECCCCCCCCHHHSCC T ss_pred HHHHHHcCCCCCCCCCCC----CCCCChHHHHHHHHHHHhhccCCCCCCCCCChhhhhhheeEeeEEeeccccccccccc Confidence 689999999999998651 2235689999999987655321100 0111223456788887654332100 1 Q NP_000548.2 216 VVRKQRYVFDISALE----K-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG 290 (501) Q Consensus 216 ~~~~~~l~FnlSsi~----~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g 290 (501) ......+.|++++++ . +.|.+|+||||+..... ...|.||...... ...++..+.+.....++ T Consensus 98 ~~~~~~l~F~ls~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~~-~~~~l~~~~v~~~~~~~ 165 (249) T 6GFF_G 98 STHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSNN-SWRYLSNRLLAPSDSPE 165 (249) T ss_dssp CTTEEEEEEEHHHHHHHSSSGGGEEEEEEEEEECCBSS-----------CEEEEEEECCSSS-CCEEEEEEEECCBSSCE T ss_pred CCCcEEEEeehHHhhccCCCcceEEEEEEEEEEcCCCc-----------eEEEEEEEecCCC-ceeEeEEEEeCCCCCCC Confidence 234677999999752 2 47999999999987642 3567777643210 11123333221234579 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA--QLCLELEAW 316 (501) Q Consensus 291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~ 316 (501) |+.||||.+|+.|+.++ +++|.|.+. T Consensus 166 W~~~dVt~~v~~W~~~~~~n~~l~v~v~ 193 (249) T 6GFF_G 166 WLSFDVTGVVRQWLSRGGEIEGFRLSAH 193 (249) T ss_dssp EEEEECHHHHHHHHHSCCSEEEEEEEEC T ss_pred eEEEEhHHHHHHHHHcCCCccCEEEEEE Confidence 99999999999999987 788886554 No 46 >5HLZ_E Inhibin beta A chain; Growth factor, Precursor, Signalling, Signaling; 2.851A {Homo sapiens} Probab=98.74 E-value=1.8e-12 Score=124.55 Aligned_cols=155 Identities=15% Similarity=0.223 Sum_probs=99.6 Template_Neff=9.000 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG------N----SSVKLEAGLANTITSFIDKGQDD 212 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~------~----~~~~~~~~~~n~Vrsf~~~~~~~ 212 (501) .+||++|||+.+|+++.. .+ .+++|++||+.+........ + ..++.....+++|++|.+.+. T Consensus 41 ~~IL~~LGl~~~P~~~~~----~~--~p~~M~~LY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~I~sf~~~~~-- 112 (270) T 5HLZ_E 41 KHILNMLHLKKRPDVTQP----VP--KAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGT-- 112 (270) T ss_pred HHHHHHcCCCCCCCCCCC----CC--hHHHHHHHHHhhcCcccCCCceeccccccchhhhhhhhcceEEEEEEecCCC-- Confidence 689999999999998651 11 38999999998765442100 0 001123345678888876532 Q NP_000548.2 213 RGPVVRKQRYVFDISA-LEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGR------------------ 272 (501) Q Consensus 213 ~~~~~~~~~l~FnlSs-i~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~------------------ 272 (501) ....+.|+++. .+. +.|.+|+||||+....... ......+.||...... T Consensus 113 -----~~~~l~F~~s~~~~~~~~v~~AeL~l~~~~~~~~~------~~~~~~i~vy~~~~~~~~~~~~~~~~~~~g~~~~ 181 (270) T 5HLZ_E 113 -----ARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANR------TRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGE 181 (270) T ss_pred -----ccEEEEEEecCCCCCceeEEEEEEEEEEeCCCcCC------CcceEEEEEEEEeeCCCCCCCCCchhhhhcCCcc Confidence 34578999987 433 4699999999998764310 1124566777543210 Q NP_000548.2 273 QPAALLDVRSVPGLDGSGWEVFDIWKLFRNFKNSA--QLCLELEAWE 317 (501) Q Consensus 273 ~~~~ll~s~~v~~~~~~gWv~fDVT~aV~~Wl~~~--nlgL~V~~~~ 317 (501) ....++.++.+ .....+|++|||+.+|+.|+..+ +++|.|.+.. T Consensus 182 ~~~~ll~s~~v-~~~~~gW~~fdVt~~v~~W~~~~~~n~gl~v~~~~ 227 (270) T 5HLZ_E 182 RSELLLSEKVV-DARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQ 227 (270) T ss_pred ceEEEEEEEEe-ecCCCceEEEEChHHHHHHHHcCCCCeeEEEEEEe Confidence 01112333333 23457999999999999999986 7898887754 No 47 >4YCG_B pro-BMP9 prodomain, human BMP9 growth; pro-BMP complex, morphogen, transforming growth; HET: NAG, ZN; 3.3A {Mus musculus} Probab=98.69 E-value=3.5e-12 Score=124.35 Aligned_cols=152 Identities=18% Similarity=0.323 Sum_probs=81.5 Template_Neff=8.500 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRG----PVVR 218 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~~~~~~~~~~~n~Vrsf~~~~~~~~~----~~~~ 218 (501) .+||++|||.++|++... ...+++||++||+.+...... ...+++|++|.+....... .... T Consensus 41 ~~IL~~LgL~~~P~~~~~-----~~~~p~yMl~LY~~~~~~~~~---------~~~~ntvRsf~~~~~~~~~~~~~~~~~ 106 (296) T 4YCG_B 41 VDFLRSLNLSGIPSQDKT-----RAEPPQYMIDLYNRYTTDKSS---------TPASNIVRSFSVEDAISTAATEDFPFQ 106 (296) T ss_dssp -------------------------CCCHHHHHHHHHHHHCTTS---------CCSCSEEEEEECCEEEEECCCSSSCSE T ss_pred HHHHHHCCCCCCCCCCCC-----CCCCCHHHHHHHHHhhcCCCC---------CCCccceeeeehhhhcccccCCCCCCC Confidence 589999999999997641 124589999999987655321 1245677777654332110 0124 Q NP_000548.2 219 KQRYVFDISALEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQ-------PAALLDVRSVPGLDGSG 290 (501) Q Consensus 219 ~~~l~FnlSsi~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~-------~~~ll~s~~v~~~~~~g 290 (501) ...+.|+++ ++. +.|..|+||||+........ .......|.||....... ...++... .....+ T Consensus 107 ~~~L~F~lS-~p~~e~v~~AeLrl~~~~~~~~~~----~~~~~~~V~Vy~v~~~~~~~~~~~~~~~lL~~~---~~~~~g 178 (296) T 4YCG_B 107 KHILIFNIS-IPRHEQITRAELRLYVSCQNDVDS----THGLEGSMVVYDVLEDSETWDQATGTKTFLVSQ---DIRDEG 178 (296) T ss_dssp EEEEECCCC-CCTTEEEEEEEEEEEEEECSCTTG----GGCCCEEEEEEEEEECCSSCSSSSSEEEEEEEE---EECSSE T ss_pred cEEEEEEEe-cCchhceEEEEEEEEeecCCCccC----CCCcEEEEEEEEeccccccccccCCcEEEEEEE---EcCCCe Confidence 567899998 653 68999999999887643110 011245677776432100 01112222 234579 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA----QLCLELEAW 316 (501) Q Consensus 291 Wv~fDVT~aV~~Wl~~~----nlgL~V~~~ 316 (501) |+.||||.+|+.|+.++ +++|+|.+. T Consensus 179 W~~fDVT~~V~~W~~~~~~~~~~gL~v~~~ 208 (296) T 4YCG_B 179 WETLEVSSAVKRWVRADSTTNKNKLEVTVQ 208 (296) T ss_dssp EEEEECHHHHHHHHSCCSSSCCSEEEEEEE T ss_pred eEEEEhHHHHHHHHHCCCCCCCceEEEEEE Confidence 99999999999999985 478887664 No 48 >4YCI_B mouse pro-BMP9 prodomain, pro-BMP9 growth; pro-BMP complex, morphogen, transforming growth; HET: ZN, NAG; 3.25A {Mus musculus} Probab=98.69 E-value=3.5e-12 Score=124.35 Aligned_cols=152 Identities=18% Similarity=0.323 Sum_probs=81.5 Template_Neff=8.500 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRG----PVVR 218 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~~~~~~~~~~~n~Vrsf~~~~~~~~~----~~~~ 218 (501) .+||++|||.++|++... ...+++||++||+.+...... ...+++|++|.+....... .... T Consensus 41 ~~IL~~LgL~~~P~~~~~-----~~~~p~yMl~LY~~~~~~~~~---------~~~~ntvRsf~~~~~~~~~~~~~~~~~ 106 (296) T 4YCI_B 41 VDFLRSLNLSGIPSQDKT-----RAEPPQYMIDLYNRYTTDKSS---------TPASNIVRSFSVEDAISTAATEDFPFQ 106 (296) T ss_dssp -------------------------CCCHHHHHHHHHHHHCTTS---------CCSCSEEEEEECCEEEEECCCSSSCSE T ss_pred HHHHHHCCCCCCCCCCCC-----CCCCCHHHHHHHHHhhcCCCC---------CCCccceeeeehhhhcccccCCCCCCC Confidence 589999999999997641 124589999999987655321 1245677777654332110 0124 Q NP_000548.2 219 KQRYVFDISALEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQ-------PAALLDVRSVPGLDGSG 290 (501) Q Consensus 219 ~~~l~FnlSsi~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~-------~~~ll~s~~v~~~~~~g 290 (501) ...+.|+++ ++. +.|..|+||||+........ .......|.||....... ...++... .....+ T Consensus 107 ~~~L~F~lS-~p~~e~v~~AeLrl~~~~~~~~~~----~~~~~~~V~Vy~v~~~~~~~~~~~~~~~lL~~~---~~~~~g 178 (296) T 4YCI_B 107 KHILIFNIS-IPRHEQITRAELRLYVSCQNDVDS----THGLEGSMVVYDVLEDSETWDQATGTKTFLVSQ---DIRDEG 178 (296) T ss_dssp EEEEECCCC-CCTTEEEEEEEEEEEEEECSCTTC----TTCCCEEEEEEEEEECCSSCSTTSSEEEEEEEE---EECSSE T ss_pred cEEEEEEEe-cCchhceEEEEEEEEeecCCCccC----CCCcEEEEEEEEeccccccccccCCcEEEEEEE---EcCCCe Confidence 567899998 653 68999999999887643110 011245677776432100 01112222 234579 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA----QLCLELEAW 316 (501) Q Consensus 291 Wv~fDVT~aV~~Wl~~~----nlgL~V~~~ 316 (501) |+.||||.+|+.|+.++ +++|+|.+. T Consensus 179 W~~fDVT~~V~~W~~~~~~~~~~gL~v~~~ 208 (296) T 4YCI_B 179 WETLEVSSAVKRWVRADSTTNKNKLEVTVQ 208 (296) T ss_dssp EEEEECHHHHHHHHSCTTSSCCSEEEEEEE T ss_pred eEEEEhHHHHHHHHHCCCCCCCceEEEEEE Confidence 99999999999999985 478887664 No 49 >4NT5_A von Willebrand factor; cystine knot, dimerization of VWF; HET: SO4, NAG; 3.281A {Homo sapiens} Probab=75.72 E-value=0.27 Score=37.97 Aligned_cols=65 Identities=22% Similarity=0.456 Sum_probs=39.6 Template_Neff=7.800 Q NP_000548.2 422 LEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 422 ~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ..+..++|.|.|...... +... . .....-.||.|.++....|...=.+|.. ..+.=+++.+|+|. T Consensus 37 ~~v~~~~C~G~C~S~~~~-----~~~~--~------~~~~~c~CC~p~~~~~~~v~L~C~~g~~--~~~~~~~i~~C~C~ 101 (107) T 4NT5_A 37 VEVDIHYCQGKCASKAMY-----SIDI--N------DVQDQCSCCSPTRTEPMQVALHCTNGSV--VYHEVLNAMECKCS 101 (107) T ss_dssp SCEEEEECCCBCCEEEEE-----ETTT--T------EEEEEEEEEEESSEEEEEEEEECTTSCE--EEEEEEEECCEEEE T ss_pred eeeeceEEeEeecCceee-----cCCc--c------ceEeecCcccCeEeEeEEEEEECCCCCE--EEEEEEeeeeceEE Confidence 567889999999875321 1100 0 0123578999999987776444333332 23344678899994 No 50 >2KD3_A Sclerostin; Protein, antagonist of CYTOKINE, PROTEIN; NMR {Mus musculus} Probab=73.48 E-value=0.35 Score=38.01 Aligned_cols=73 Identities=15% Similarity=0.291 Sum_probs=40.9 Template_Neff=6.600 Q NP_000548.2 419 IAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANN-VVYKQYEDMVVES 497 (501) Q Consensus 419 iaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~-~~~~~~~~mvv~~ 497 (501) ++.+.+...+|.|.|....... ...... ... . ......||.|.++....|.+.=.+|. .+ ...-+.|.+ T Consensus 39 ~S~~~v~~~~C~G~C~s~s~~~---~~~~~~-~~~-~---~~~~c~CC~p~~t~~r~V~l~C~dG~~~~--~~~~~~V~~ 108 (113) T 2KD3_A 39 RSAKPVTELVCSGQCGPARLLP---NAIGRV-KWW-R---PNGPDFRCIPDRYRAQRVQLLCPGGAAPR--SRKVRLVAS 108 (113) T ss_dssp EECCCCCBCCCCCCCSCCCCCC---CCTTCC-SSS-C---SSCCCCCCEEEEEEEEEEEEECTTSEE------EEEEEEE T ss_pred eeCCccccceeeeeCCCCccCC---cccCCC-Ccc-c---ccCCCccccCceeEEEEEEEECCCCCeeE--EEEeEEEee Confidence 4456678889999998653210 000000 000 0 12357899999999877655433342 22 334468899 Q NP_000548.2 498 CGCR 501 (501) Q Consensus 498 CgC~ 501 (501) |+|. T Consensus 109 C~C~ 112 (113) T 2KD3_A 109 CKCK 112 (113) T ss_dssp EECC T ss_pred cccC Confidence 9994 No 51 >4YU8_A Neuroblastoma suppressor of tumorigenicity 1; BMP Binding Protein, NBL1 DAN; HET: NAG; 1.8A {Homo sapiens} Probab=70.00 E-value=0.48 Score=38.53 Aligned_cols=88 Identities=13% Similarity=0.121 Sum_probs=41.4 Template_Neff=7.100 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501) Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501) ..|....+...+..=| - . +..+..++|.|.|....... ... ... .....-.||.|.++....|- T Consensus 32 ~~C~~~~~~~~I~~~g---C-~-s~~V~~~~C~G~C~S~s~~~----~~~---~~~----~~~~~CsCC~p~~~~~~~V~ 95 (139) T 4YU8_A 32 AWCEAKNITQIVGHSG---C-E-AKSIQNRACLGQCFSYSVPN----TFP---QST----ESLVHCDSCMPAQSMWEIVT 95 (139) T ss_dssp CEEEEEEEEEEECCTT---S-C-CEEEEEEEEEEECCC------------------------------EEEEEEEEEEEE T ss_pred CccEEEeeEEEEecCC---c-e-eeeeecceeeceecccccCC----CCC---CCc----cceeecCcccCeEEEEEEEE Confidence 3566555444443211 1 2 25678899999998753210 000 000 01123469999999977664 Q NP_000548.2 478 FIDSANNV-VYKQYEDMVVESCGCR 501 (501) Q Consensus 478 y~d~~~~~-~~~~~~~mvv~~CgC~ 501 (501) ..=.++.. ....+.=..+.+|+|. T Consensus 96 L~C~~g~~~~~~~~~~~~v~sC~C~ 120 (139) T 4YU8_A 96 LECPGHEEVPRVDKLVEKILHCSCQ 120 (139) T ss_dssp EECTTCSSSCEEEEEEEEEEEEEEC T ss_pred EeCCCCCCcccEEEEEEeeeecccc Confidence 33233322 0022333478999995 No 52 >2K8P_A Sclerostin; WNT SIGNALLING PATHWAY, BONE FORMATION; NMR {Homo sapiens} Probab=66.67 E-value=0.66 Score=39.89 Aligned_cols=74 Identities=18% Similarity=0.288 Sum_probs=43.0 Template_Neff=5.300 Q NP_000548.2 419 IAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESC 498 (501) Q Consensus 419 iaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~C 498 (501) .+.+.+...+|.|.|...... .+.. -...... ......||+|.+.....|-+.=.+|. ....+.-|+|.+| T Consensus 71 ~S~kpV~~~~C~G~C~~~s~~----~~~~-~~~k~~~---~~~~~~CC~P~rTrtrrV~f~C~DGt-~t~~~~v~~V~sC 141 (189) T 2K8P_A 71 RSAKPVTELVCSGQCGPARLL----PNAI-GRGKWWR---PSGPDFRCIPDRYRAQRVQLLCPGGE-APRARKVRLVASC 141 (189) T ss_dssp EESSCEEEEEECCCCCCCCCC----SSCC-CSSCCCS---CCCCCCCCEECCEEEEEEEEECCTTS-CCEEEEEEEECCE T ss_pred ecCCceeeeEEeeeCCCcccC----CCcc-cCCCccC---CCCCCCCCCCCeeEEEEEEEECCCCC-cceeEEeeEeeeC Confidence 556777889999999864321 0100 0000001 12357899999988766655434342 0123345789999 Q NP_000548.2 499 GCR 501 (501) Q Consensus 499 gC~ 501 (501) +|. T Consensus 142 kCk 144 (189) T 2K8P_A 142 KCK 144 (189) T ss_dssp ECC T ss_pred CCc Confidence 994 No 53 >4JPH_D Gremlin-2; Cystine knot, DAN domain, CAN; HET: GSH, GOL, CIT; 2.25A {Mus musculus} Probab=65.08 E-value=0.72 Score=37.91 Aligned_cols=88 Identities=14% Similarity=0.239 Sum_probs=48.1 Template_Neff=6.700 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501) Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501) ..|....+...+..=|= .+ ..+..++|.|.|....... ....... ....-.||.|.++....|. T Consensus 51 ~~C~~~~~~q~I~~~gC----~s-~~V~~~~C~G~C~S~s~p~----~~~~~~~-------~~~~CsCC~p~~~~~~~V~ 114 (148) T 4JPH_D 51 DWCKTQPLRQTVSEEGC----RS-RTILNRFCYGQCNSFYIPR----HVKKEED-------SFQSCAFCKPQRVTSVIVE 114 (148) T ss_dssp CEEEEEEEEEEECCTTS----CC-EEEEEEEEEEEEEEEEEEC----CCSSSCC-------EEEEEEEEEEEEEEEEEEE T ss_pred CceeeEeceEEEccCCc----ee-eeEEeceeeeecCcccccc----cCCCccc-------cccccCcccCeEEEEEEEE Confidence 45776666555442221 22 4678899999998643210 0000000 1234689999999976664 Q NP_000548.2 478 FIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 478 y~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ..=.++.-......=..|.+|+|. T Consensus 115 L~C~~g~~~~~~~~v~~V~sC~C~ 138 (148) T 4JPH_D 115 LECPGLDPPFRIKKIQKVKHCRCM 138 (148) T ss_dssp ECCTTSSSSCEEEEEEEEEEEEEE T ss_pred EeCCCCCCCceEEEEEeeeeCcee Confidence 332222211122334588999995 No 54 >4X1J_B Neuroblastoma suppressor of tumorigenicity 1; BMP antagonist, DAN family, Cystine-knot; HET: NAG; 2.5A {Homo sapiens} Probab=64.18 E-value=0.74 Score=35.85 Aligned_cols=88 Identities=13% Similarity=0.131 Sum_probs=46.1 Template_Neff=7.700 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501) Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501) ..|....+...+..=|= .+..+..++|.|.|....... ... ... .....-.||.|.++....|. T Consensus 17 ~~C~~~~~~~~i~~~gC-----~s~~i~~~~C~G~C~S~~~~~----~~~---~~~----~~~~~C~CC~p~~~~~~~V~ 80 (116) T 4X1J_B 17 AWCEAKNITQIVGHSGC-----EAKSIQNRACLGQCFSYSVPN----TFP---QST----ESLVHCDSCMPAQSMWEIVT 80 (116) T ss_dssp CEEEEEEEEEEECCTTS-----CCEEEEEEEEEEEEEEEECC------------------CTTEEEEEEEEEEEEEEEEE T ss_pred CccEEEEeEEEEccCCc-----cceeEecceEeeeeeeeeecC----CCC---CCC----cceeecCCccceEEEEEEEE Confidence 35666555444432111 123578899999998643210 000 000 01234579999999987764 Q NP_000548.2 478 FIDSANNV-VYKQYEDMVVESCGCR 501 (501) Q Consensus 478 y~d~~~~~-~~~~~~~mvv~~CgC~ 501 (501) ..=.++.- ......=.++.+|+|. T Consensus 81 L~C~~g~~~~~~~~~~~~v~~C~C~ 105 (116) T 4X1J_B 81 LECPGHEEVPRVDKLVEKILHCSCQ 105 (116) T ss_dssp EECTTCSSSSEEEEEEEEEEEEEEE T ss_pred EECCCCCCCccEEEEEEeeEecccc Confidence 43233322 1122333478999995 No 55 >5AEJ_A GREMLIN-1; SIGNALING PROTEIN, SIGNALING, GREMLIN, GROWTH; HET: SO4; 1.904A {HOMO SAPIENS} Probab=62.64 E-value=0.87 Score=37.64 Aligned_cols=87 Identities=15% Similarity=0.248 Sum_probs=48.6 Template_Neff=6.100 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISI 476 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~i 476 (501) ...|....+...+..=|= . +..+..++|.|.|...... ... . .. . .....-.||.|.++....| T Consensus 59 ~~~C~~~~~~q~I~~~gC----~-S~~V~~~~C~G~C~S~s~p-----s~~-~-~~---~-~~~~~CsCC~p~~s~~~~V 122 (152) T 5AEJ_A 59 RDWCKTQPLKQTIHEEGC----N-SRTIINRFCYGQCNSFYIP-----RHI-R-KE---E-GSFQSCSFCKPKKFTTMMV 122 (152) T ss_dssp CCEEEEEEEEEEECCTTS----C-CEEEEEEEEEEEEEEEEEE-----EEE-T-TE---E-EEEEEEEEEEEEEEEEEEE T ss_pred CCceeeeeceeEEccCCc----e-eceEEeeeceeecccCeec-----ccc-c-cc---C-CceeecCcccceEEEEEEE Confidence 456877766555542221 2 2568899999999864321 100 0 00 0 0122467999999987666 Q NP_000548.2 477 LFIDSANNV--VYKQYEDMVVESCGCR 501 (501) Q Consensus 477 ly~d~~~~~--~~~~~~~mvv~~CgC~ 501 (501) ...=.++.. +.+.+ ..+.+|.|. T Consensus 123 ~L~Cpdg~~~~~~~~v--~~V~sC~C~ 147 (152) T 5AEJ_A 123 TLNCPELQPPTKKKRV--TRVKQCRCI 147 (152) T ss_dssp EEECTTSSSSEEEEEE--EEEEEEEEE T ss_pred EEECCCCCCCceEEEE--EeceeceeE Confidence 333222322 23333 578999995 No 56 >5HK5_G Gremlin-2, Growth/differentiation factor 5; DAN-family, Bone Morphogenetic Proteins, CYTOKINE; 2.9A {Mus musculus} Probab=61.90 E-value=0.91 Score=37.23 Aligned_cols=86 Identities=15% Similarity=0.240 Sum_probs=46.5 Template_Neff=6.600 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501) Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501) ..|....+...+..=|= .+ ..+..++|.|.|....... ....... ....-.||.|.++....|. T Consensus 50 ~~C~~~~~~q~I~~~gC----~s-~~V~~~~C~G~C~S~s~ps----~~~~~~~-------~~~~CsCC~p~~~~~~~V~ 113 (147) T 5HK5_G 50 DWCKTQPLRQTVSEEGC----RS-RTILNRFCYGQCNSFYIPR----HVKKEED-------SFQSCAFCKPQRVTSVIVE 113 (147) T ss_pred CceeeEeceEEEccCCc----ee-eeEEeceeeeecCcccccc----cCCCccc-------cccccCcccCeEEEEEEEE Confidence 35665555544432121 22 4578899999998643210 0000000 1234679999999976663 Q NP_000548.2 478 FIDSANNV--VYKQYEDMVVESCGCR 501 (501) Q Consensus 478 y~d~~~~~--~~~~~~~mvv~~CgC~ 501 (501) ..=.++.. +.+. =.+|.+|+|. T Consensus 114 L~C~dg~~~~~~~~--~~~V~sC~C~ 137 (147) T 5HK5_G 114 LECPGLDPPFRIKK--IQKVKHCRCM 137 (147) T ss_pred EeCCCCCCCceEEE--EEeeeeCcee Confidence 33222221 2333 3578999994 No 57 >5BPU_A Frizzled-4; Wnt signalling pathway, Norrie disease; HET: GGL; 2.4A {Homo sapiens} Probab=57.82 E-value=1.2 Score=34.98 Aligned_cols=72 Identities=21% Similarity=0.280 Sum_probs=38.3 Template_Neff=7.700 Q NP_000548.2 422 LEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 422 ~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ..+..++|.|.|....... ........ ........-.||.|.++....+...=.++..+. ..-.++.+|.|. T Consensus 37 ~~v~~~~C~G~C~S~~~~~----p~~~~~~~--~~~~~~~~C~CC~p~~~~~~~v~l~C~~g~~~~--~~~~~i~~C~C~ 108 (122) T 5BPU_A 37 KMVLLARCEGHCSQASRSE----PLVSFSTV--LKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLT--ATYRYILSCHCE 108 (122) T ss_pred CcEeceeeeccccceeecC----CCcccCCC--CCCcceeeeecCcCeEeEEEEEEEECCCCCeEE--EEEEEEEeceee Confidence 6678899999998753200 00000000 000012345899999988766533323332222 333478899994 No 58 >5BQ8_C Norrin; Wnt signalling pathway, Norrie disease; HET: MLY; 2.0A {Homo sapiens} Probab=53.96 E-value=1.5 Score=34.27 Aligned_cols=93 Identities=19% Similarity=0.268 Sum_probs=46.5 Template_Neff=7.800 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501) Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501) ..|....+...+..=.. .- .. ..+..++|.|.|....... ........ ........-.||.|.++....|. T Consensus 16 ~~C~~~~~~~~i~~~~~-gC-~s-~~v~~~~C~G~C~S~~~~~----p~~~~~~~--~~~~~~~~C~CC~p~~~~~~~V~ 86 (122) T 5BQ8_C 16 RRCMRHHYVDSISHPLY-KC-SS-KMVLLARCEGHCSQASRSE----PLVSFSTV--LKQPFRSSCHCCRPQTSKLKALR 86 (122) T ss_dssp TSSEEEEEEEEECCSSS-CB-CC-EEEEEEEEEECCSSCEEEE----ECCEETTB--CCCSEEEECEEEEEEEEEEEEEE T ss_pred CCeEEEeeEEEEEcCCC-Cc-ee-ceeEeeeEEEecccceecC----CccccCCC--CCCCceeEceecCCeEeEEEEEE Confidence 45666555444432100 11 22 6678899999998753200 00000000 00001234589999998876653 Q NP_000548.2 478 FIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 478 y~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ..=.++..+ ...-+++.+|.|. T Consensus 87 l~C~~g~~~--~~~~~~i~~C~C~ 108 (122) T 5BQ8_C 87 LRCSGGMRL--TATYRYILSCHCE 108 (122) T ss_dssp EEETTTEEE--EEEEEEEEEEEEE T ss_pred EECCCCceE--EEEEEEEEeceee Confidence 332333322 2334578999994 No 59 >5BQE_A Frizzled-4; Wnt signalling pathway, Norrie disease; HET: MLY, NAG, PG0; 2.3A {Homo sapiens} Probab=53.96 E-value=1.5 Score=34.27 Aligned_cols=93 Identities=19% Similarity=0.268 Sum_probs=46.5 Template_Neff=7.800 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501) Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501) ..|....+...+..=.. .- .. ..+..++|.|.|....... ........ ........-.||.|.++....|. T Consensus 16 ~~C~~~~~~~~i~~~~~-gC-~s-~~v~~~~C~G~C~S~~~~~----p~~~~~~~--~~~~~~~~C~CC~p~~~~~~~V~ 86 (122) T 5BQE_A 16 RRCMRHHYVDSISHPLY-KC-SS-KMVLLARCEGHCSQASRSE----PLVSFSTV--LKQPFRSSCHCCRPQTSKLKALR 86 (122) T ss_dssp TSSEEEEEEEEECCSSS-CB-CC-EEEEEEEEEECCSSCEEEE----ECCBCSSS--CSSCEEEECEEEEEEEEEEEEEE T ss_pred CCeEEEeeEEEEEcCCC-Cc-ee-ceeEeeeEEEecccceecC----CccccCCC--CCCCceeEceecCCeEeEEEEEE Confidence 45666555444432100 11 22 6678899999998753200 00000000 00001234589999998876653 Q NP_000548.2 478 FIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 478 y~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ..=.++..+ ...-+++.+|.|. T Consensus 87 l~C~~g~~~--~~~~~~i~~C~C~ 108 (122) T 5BQE_A 87 LRCSGGMRL--TATYRYILSCHCE 108 (122) T ss_dssp EEBSSSCEE--EEEEEEEEEEEEE T ss_pred EECCCCceE--EEEEEEEEeceee Confidence 332333322 2334578999994 Query NP_000836.2 Match_columns 908 No_of_seqs 3628 out of 54127 Neff 10.7604 Searched_HMMs 7012 Date Sun Jul 26 14:02:06 2020 Command /home/guerler/hh-suite/build/bin/hhblits -i /home/guerler/human/fasta/NP_00/NP_000836.2.fasta -d /home/guerler/pdb70/pdb70 -o /home/guerler/human/hhr/NP_00/NP_000836.2.hhr No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 6N4X_A Metabotropic glutamate 100.0 2.5E-77 1.8E-81 724.0 0.0 801 35-855 30-845 (877) 2 6N52_B Metabotropic glutamate 100.0 1.2E-76 8.4E-81 718.1 0.0 803 34-856 29-846 (871) 3 6N51_B Metabotropic glutamate 100.0 6.7E-76 4.8E-80 706.5 0.0 786 37-842 4-804 (804) 4 6W2Y_A Gamma-aminobutyric acid 100.0 3.8E-66 2.8E-70 620.7 0.0 685 36-853 22-734 (829) 5 6W2X_B Gamma-aminobutyric acid 100.0 8.6E-65 6.2E-69 611.4 0.0 678 36-852 13-725 (908) 6 6UO8_A Gamma-aminobutyric acid 100.0 9.3E-65 6.7E-69 605.5 0.0 682 42-856 3-712 (762) 7 6UO8_B Gamma-aminobutyric acid 100.0 2.2E-64 1.6E-68 602.9 0.0 675 39-852 9-718 (779) 8 7C7Q_A Gamma-aminobutyric acid 100.0 3.4E-62 2.5E-66 592.4 0.0 685 40-855 166-876 (879) 9 2E4U_A Metabotropic glutamate 100.0 1.2E-43 8.6E-48 406.8 0.0 535 40-584 9-553 (555) 10 2E4X_B Metabotropic glutamate 100.0 1.2E-43 8.6E-48 406.8 0.0 535 40-584 9-553 (555) 11 6N50_A Metabotropic glutamate 100.0 4.1E-43 3E-47 405.6 0.0 536 36-576 42-589 (596) 12 6N4Y_C Metabotropic glutamate 100.0 4.4E-43 3.2E-47 405.3 0.0 536 36-576 42-589 (596) 13 5K5S_B Extracellular calcium-s 100.0 1.3E-42 9.6E-47 402.9 0.0 534 39-580 25-609 (615) 14 5KZQ_A Metabotropic glutamate 100.0 1.7E-42 1.2E-46 398.2 0.0 529 38-580 24-564 (570) 15 5K5T_A Extracellular calcium-s 100.0 2.4E-42 1.8E-46 400.9 0.0 534 39-580 25-609 (615) 16 6FFH_A Metabotropic glutamate 100.0 9.6E-38 6.9E-42 309.0 0.0 266 573-852 4-431 (444) 17 6FFI_A Metabotropic glutamate 100.0 9.6E-38 6.9E-42 309.0 0.0 266 573-852 4-431 (444) 18 4OR2_B Chimera of Soluble cyto 100.0 1.8E-37 1.3E-41 330.2 0.0 271 570-854 108-380 (389) 19 6BT5_B Metabotropic glutamate 99.9 2.3E-27 1.7E-31 265.1 0.0 468 40-507 4-471 (479) 20 6BSZ_A Metabotropic glutamate 99.9 3.3E-27 2.4E-31 263.8 0.0 468 40-507 4-471 (479) 21 3KS9_B Metabotropic glutamate 99.8 1.4E-26 1E-30 259.8 0.0 465 37-506 9-489 (496) 22 4XAR_A Metabotropic glutamate 99.8 1.6E-26 1.2E-30 260.6 0.0 462 37-506 32-503 (517) 23 6B7H_A Metabotropic glutamate 99.8 1.6E-26 1.2E-30 260.6 0.0 462 37-506 32-503 (517) 24 1EWK_B METABOTROPIC GLUTAMATE 99.8 1.8E-26 1.3E-30 258.4 0.0 464 38-506 5-484 (490) 25 1EWT_A METABOTROPIC GLUTAMATE 99.8 1.8E-26 1.3E-30 258.4 0.0 464 38-506 5-484 (490) 26 5C5C_A Metabotropic glutamate 99.8 2E-26 1.4E-30 257.7 0.0 468 38-505 9-480 (481) 27 3SM9_A Metabotropic glutamate 99.8 2.4E-26 1.7E-30 256.8 0.0 459 40-506 8-476 (479) 28 4XAQ_A Metabotropic glutamate 99.8 9.3E-26 6.8E-30 253.4 0.0 453 40-506 28-491 (503) 29 5CNI_A Metabotropic glutamate 99.8 9.3E-26 6.8E-30 253.4 0.0 453 40-506 28-491 (503) 30 5CNJ_A Metabotropic glutamate 99.8 1.1E-25 7.8E-30 252.8 0.0 454 39-506 27-491 (503) 31 5FBK_A Extracellular calcium-s 99.8 3.8E-25 2.8E-29 252.0 0.0 460 40-507 53-560 (568) 32 5FBK_B Extracellular calcium-s 99.8 4.7E-25 3.4E-29 251.3 0.0 460 40-507 53-560 (568) 33 1DP4_A ATRIAL NATRIURETIC PEPT 99.8 2.8E-24 2E-28 236.6 0.0 369 44-494 1-397 (435) 34 1DP4_C ATRIAL NATRIURETIC PEPT 99.8 2.8E-24 2E-28 236.6 0.0 369 44-494 1-397 (435) 35 5X2M_A Taste receptor, type 1, 99.8 4.3E-24 3.1E-28 237.0 0.0 419 35-494 4-432 (461) 36 5X2N_C Taste receptor, type 1, 99.8 4.3E-24 3.1E-28 237.0 0.0 419 35-494 4-432 (461) 37 5X2M_B Taste receptor, type 1, 99.8 1.5E-23 1.1E-27 233.8 0.0 440 39-512 12-470 (478) 38 5X2N_B Taste receptor, type 1, 99.8 1.5E-23 1.1E-27 233.8 0.0 440 39-512 12-470 (478) 39 5X2N_D Taste receptor, type 1, 99.8 1.5E-23 1.1E-27 233.8 0.0 440 39-512 12-470 (478) 40 1JDN_A ATRIAL NATRIURETIC PEPT 99.8 2E-23 1.4E-27 230.1 0.0 372 41-494 5-395 (441) 41 1JDP_A ATRIAL NATRIURETIC PEPT 99.8 2E-23 1.4E-27 230.1 0.0 372 41-494 5-395 (441) 42 4F11_A Gamma-aminobutyric acid 99.7 2E-22 1.4E-26 221.5 0.0 391 39-506 8-419 (433) 43 4MS4_B Gamma-aminobutyric acid 99.7 2E-22 1.4E-26 221.5 0.0 391 39-506 8-419 (433) 44 4MQE_A Gamma-aminobutyric acid 99.7 2E-21 1.4E-25 212.4 0.0 376 43-494 3-392 (420) 45 4MS4_A Gamma-aminobutyric acid 99.7 2E-21 1.4E-25 212.4 0.0 376 43-494 3-392 (420) 46 3Q41_C Glutamate [NMDA] recept 99.7 4.8E-21 3.4E-25 206.5 0.0 348 42-507 3-364 (384) 47 5KC8_A Glutamate receptor iono 99.6 9.9E-21 7.1E-25 207.4 0.0 378 42-495 3-403 (429) 48 3OM0_A Glutamate receptor, ion 99.6 2.1E-20 1.5E-24 201.9 0.0 370 43-495 2-376 (393) 49 3QLU_B Glutamate receptor, ion 99.6 2.1E-20 1.5E-24 201.9 0.0 370 43-495 2-376 (393) 50 5FWY_B GLUTAMATE RECEPTOR 2, G 99.6 2.4E-20 1.7E-24 201.4 0.0 372 43-505 3-385 (390) 51 6FPJ_A Glutamate receptor 3; l 99.6 2.4E-20 1.7E-24 201.4 0.0 372 43-505 3-385 (390) 52 3H5L_A putative Branched-chain 99.6 2.8E-20 2.1E-24 203.0 0.0 363 40-493 9-385 (419) 53 3H5L_B putative Branched-chain 99.6 2.8E-20 2.1E-24 203.0 0.0 363 40-493 9-385 (419) 54 5KCA_A Cerebellin-1,Cerebellin 99.6 4.6E-20 3.3E-24 221.1 0.0 382 40-496 452-855 (878) 55 4XFK_A BrovA.17370.a; transpor 99.6 5.4E-20 3.9E-24 199.1 0.0 355 43-493 9-374 (399) 56 5KC9_A Glutamate receptor iono 99.6 5.6E-20 4.1E-24 201.2 0.0 372 42-495 3-402 (428) 57 6JFY_A Glutamate receptor iono 99.6 1.1E-19 7.8E-24 216.7 0.0 373 43-494 2-380 (809) 58 4GPA_A Glutamate receptor 4; P 99.6 1.1E-19 7.9E-24 196.1 0.0 361 43-496 3-374 (389) 59 5EWM_A NMDA glutamate receptor 99.6 1.2E-19 8.4E-24 195.9 0.0 351 43-507 2-383 (390) 60 3H6G_A Glutamate receptor, ion 99.6 1.2E-19 8.7E-24 196.1 0.0 373 43-495 2-378 (395) 61 3H6G_B Glutamate receptor, ion 99.6 1.2E-19 8.7E-24 196.1 0.0 373 43-495 2-378 (395) 62 6JFY_B Glutamate receptor iono 99.6 1.2E-19 8.9E-24 216.1 0.0 373 43-494 2-380 (809) 63 5L2E_B Cerebellin-1; Synapse P 99.6 1.3E-19 9.3E-24 211.8 0.0 379 42-495 2-402 (688) 64 3QEK_B NMDA glutamate receptor 99.6 1.3E-19 9.4E-24 195.1 0.0 349 43-505 3-382 (384) 65 6LU9_D Glutamate receptor iono 99.6 1.3E-19 9.6E-24 218.0 0.0 374 44-494 2-399 (877) 66 1USG_A LEUCINE-SPECIFIC BINDIN 99.6 2.1E-19 1.5E-23 190.1 0.0 335 44-477 1-337 (346) 67 3IP6_A ABC transporter, substr 99.6 2.6E-19 1.9E-23 190.4 0.0 349 44-493 1-351 (356) 68 3IPC_A ABC transporter, substr 99.6 2.7E-19 2E-23 190.1 0.0 348 45-493 2-351 (356) 69 4EYG_B Twin-arginine transloca 99.5 3.1E-19 2.3E-23 190.7 0.0 356 42-494 3-360 (368) 70 4EYK_A Twin-arginine transloca 99.5 3.1E-19 2.3E-23 190.7 0.0 356 42-494 3-360 (368) 71 3HUT_A putative branched-chain 99.5 4E-19 2.9E-23 189.0 0.0 350 43-493 2-353 (358) 72 5KUH_C Glutamate receptor iono 99.5 4.1E-19 3E-23 210.0 0.0 372 43-495 2-378 (757) 73 4EVQ_A Putative ABC transporte 99.5 4.1E-19 3E-23 190.4 0.0 352 39-491 10-361 (375) 74 4EVQ_B Putative ABC transporte 99.5 4.1E-19 3E-23 190.4 0.0 352 39-491 10-361 (375) 75 4N0Q_B Leu/Ile/Val-binding pro 99.5 4.2E-19 3E-23 188.6 0.0 336 43-477 8-346 (354) 76 4N0Q_C Leu/Ile/Val-binding pro 99.5 4.2E-19 3E-23 188.6 0.0 336 43-477 8-346 (354) 77 3SAJ_C Glutamate receptor 1; R 99.5 4.5E-19 3.3E-23 190.7 0.0 357 41-495 6-372 (384) 78 6E7R_B Glutamate receptor iono 99.5 6E-19 4.4E-23 188.1 0.0 348 44-505 2-361 (363) 79 6E7S_D Glutamate receptor iono 99.5 6E-19 4.4E-23 188.1 0.0 348 44-505 2-361 (363) 80 3HSY_B Glutamate receptor 2; G 99.5 6.1E-19 4.5E-23 188.9 0.0 357 44-495 1-369 (376) 81 3SAJ_B Glutamate receptor 1; R 99.5 6.5E-19 4.7E-23 189.5 0.0 357 41-495 6-372 (384) 82 3N6V_D Glutamate receptor 2; A 99.5 6.9E-19 5E-23 188.4 0.0 355 46-495 1-367 (374) 83 4GNR_A ABC transporter substra 99.5 7E-19 5.1E-23 186.7 0.0 347 41-492 3-352 (353) 84 3N0X_A Possible substrate bind 99.5 7.4E-19 5.3E-23 188.3 0.0 348 43-494 2-355 (374) 85 6KSP_B Glutamate receptor iono 99.5 7.5E-19 5.4E-23 210.7 0.0 372 44-494 2-398 (856) 86 3N6V_B Glutamate receptor 2; A 99.5 8.3E-19 6E-23 187.8 0.0 355 46-495 1-367 (374) 87 1Z17_A Leu/Ile/Val-binding pro 99.5 8.4E-19 6.1E-23 185.2 0.0 333 45-478 2-336 (344) 88 4RU0_B Putative branched-chain 99.5 1E-18 7.4E-23 192.3 0.0 370 40-494 28-416 (447) 89 5EWM_D NMDA glutamate receptor 99.5 1E-18 7.5E-23 186.3 0.0 349 43-505 2-362 (364) 90 4MLC_A Extracellular ligand-bi 99.5 1.1E-18 7.8E-23 185.4 0.0 346 40-489 5-355 (356) 91 4Q6B_A Extracellular ligand-bi 99.5 1.1E-18 7.8E-23 185.4 0.0 346 40-489 5-355 (356) 92 3TD9_A Branched chain amino ac 99.5 1.1E-18 8.1E-23 186.2 0.0 347 43-494 14-363 (366) 93 3N0W_B ABC branched chain amin 99.5 1.7E-18 1.2E-22 185.8 0.0 350 42-493 3-354 (379) 94 1PEA_A AMIDASE OPERON, ACETAMI 99.5 1.8E-18 1.3E-22 186.1 0.0 354 42-493 4-359 (385) 95 1QO0_B AMIC, AMIR; BINDING PRO 99.5 1.8E-18 1.3E-22 186.1 0.0 354 42-493 4-359 (385) 96 4KV7_A Probable leucine/isoleu 99.5 1.9E-18 1.4E-22 185.5 0.0 349 38-477 10-366 (381) 97 4OBB_B Amino acid/amide ABC tr 99.5 2E-18 1.5E-22 186.4 0.0 362 39-492 27-392 (395) 98 4RV5_B Amino acid/amide ABC tr 99.5 2E-18 1.5E-22 186.4 0.0 362 39-492 27-392 (395) 99 3I45_A Twin-arginine transloca 99.5 2.3E-18 1.6E-22 185.4 0.0 355 43-494 3-360 (387) 100 4F06_A Extracellular ligand-bi 99.5 2.9E-18 2.1E-22 183.2 0.0 356 42-492 2-361 (371) 101 4N03_A ABC-type branched-chain 99.5 4.8E-18 3.5E-22 184.1 0.0 356 40-494 28-392 (405) 102 4M88_A Extracellular ligand-bi 99.5 4.9E-18 3.5E-22 180.4 0.0 343 43-477 2-350 (357) 103 3I09_B Periplasmic branched-ch 99.5 6.2E-18 4.5E-22 181.0 0.0 347 43-492 2-349 (375) 104 5TQ0_B NMDA glutamate receptor 99.4 6.5E-18 4.7E-22 179.7 0.0 343 46-505 1-358 (360) 105 5TPW_B NMDA glutamate receptor 99.4 6.5E-18 4.7E-22 179.7 0.0 343 46-505 1-358 (360) 106 4MAA_A Putative branched-chain 99.4 9.1E-18 6.6E-22 181.7 0.0 352 40-494 29-383 (403) 107 5L1B_D Glutamate receptor 2; T 99.4 1.1E-17 8.2E-22 198.8 0.0 356 44-494 1-368 (803) 108 4TLL_D GluN1/GluN2B; Neurotran 99.4 1.3E-17 9.1E-22 199.0 0.0 340 40-494 5-358 (824) 109 4TLM_D GluN1/GluN2B; neurotran 99.4 1.3E-17 9.1E-22 199.0 0.0 340 40-494 5-358 (824) 110 4EYQ_A Extracellular ligand-bi 99.4 1.8E-17 1.3E-21 176.2 0.0 348 41-477 3-354 (362) 111 3LKB_B Probable branched-chain 99.4 1.9E-17 1.4E-21 178.4 0.0 360 42-494 4-375 (392) 112 4F8J_A Putative branched-chain 99.4 2.8E-17 2E-21 174.7 0.0 348 41-477 3-354 (362) 113 4U4G_D GluA2*; Ionotropic glut 99.4 2.9E-17 2.1E-21 195.8 0.0 356 44-494 1-368 (822) 114 6PEQ_D Glutamate receptor 2, P 99.4 3.4E-17 2.4E-21 196.9 0.0 360 40-494 21-392 (889) 115 3UK0_A Extracellular ligand-bi 99.4 3.5E-17 2.6E-21 173.9 0.0 348 41-477 3-354 (362) 116 4TLL_C GluN1/GluN2B; Neurotran 99.4 3.6E-17 2.6E-21 194.8 0.0 349 43-507 3-363 (823) 117 4TLM_C GluN1/GluN2B; neurotran 99.4 3.6E-17 2.6E-21 194.8 0.0 349 43-507 3-363 (823) 118 4MPT_B Putative leu/ile/val-bi 99.4 3.6E-17 2.6E-21 175.3 0.0 354 42-477 3-367 (380) 119 4ZPJ_A Extracellular ligand-bi 99.4 5.1E-17 3.7E-21 177.0 0.0 346 39-476 48-399 (423) 120 6DLZ_B Glutamate receptor 2,Vo 99.4 5.2E-17 3.7E-21 198.5 0.0 356 44-494 1-368 (1031) 121 3EAF_A ABC transporter, substr 99.4 6.6E-17 4.8E-21 174.0 0.0 362 43-494 2-372 (391) 122 5UOW_C N-methyl-D-aspartate re 99.4 6.8E-17 4.9E-21 192.2 0.0 336 43-494 2-348 (814) 123 3LOP_A Substrate binding perip 99.4 7.1E-17 5.1E-21 171.9 0.0 352 43-492 3-360 (364) 124 5IOV_B GluN1, GLY-GLY-GLU-GLU; 99.4 7.4E-17 5.4E-21 192.2 0.0 341 39-494 23-377 (825) 125 5WEO_A Glutamate receptor 2,Vo 99.3 1.3E-16 9.5E-21 195.0 0.0 356 44-494 1-368 (1034) 126 4DQD_A Extracellular ligand-bi 99.3 1.9E-16 1.4E-20 168.3 0.0 348 43-477 2-355 (363) 127 3SG0_A Extracellular ligand-bi 99.3 3.9E-16 2.8E-20 167.4 0.0 350 41-477 23-378 (386) 128 5ERE_A Extracellular ligand-bi 99.3 4.6E-16 3.3E-20 176.6 0.0 327 45-494 1-327 (568) 129 3CKM_A Uncharacterized protein 99.2 3.7E-15 2.7E-19 155.6 0.0 322 44-493 1-324 (327) 130 5VBG_A Penicillin-binding prot 98.9 1.6E-13 1.2E-17 154.3 0.0 215 40-311 219-434 (543) 131 5KCN_A Penicillin-binding prot 98.9 1.6E-13 1.2E-17 154.2 0.0 215 40-311 219-434 (543) 132 4PYR_A Putative branched-chain 98.9 1.7E-13 1.2E-17 141.2 0.0 204 45-311 1-205 (305) 133 4YLE_A Simple sugar transport 97.8 1.5E-08 1.1E-12 103.5 0.0 224 40-308 27-256 (316) 134 4RK1_B Ribose transcriptional 97.7 2.9E-08 2.1E-12 99.2 0.0 204 42-300 4-209 (280) 135 4RK1_D Ribose transcriptional 97.7 2.9E-08 2.1E-12 99.2 0.0 204 42-300 4-209 (280) 136 3BRQ_A HTH-type transcriptiona 97.6 3.8E-08 2.7E-12 99.3 0.0 208 41-300 15-225 (296) 137 3BRQ_B HTH-type transcriptiona 97.6 3.8E-08 2.7E-12 99.3 0.0 208 41-300 15-225 (296) 138 5DTE_B Monosaccharide-transpor 97.6 5.2E-08 3.8E-12 99.3 0.0 222 41-308 22-249 (311) 139 3KSM_B ABC-type sugar transpor 97.6 5.5E-08 4E-12 96.9 0.0 212 46-308 1-220 (276) 140 3KSM_A ABC-type sugar transpor 97.6 5.5E-08 4E-12 96.9 0.0 212 46-308 1-220 (276) 141 4RSM_A Periplasmic binding pro 97.6 5.6E-08 4.1E-12 99.9 0.0 213 40-308 7-226 (327) 142 6HBD_B ABC transporter peripla 97.6 5.7E-08 4.1E-12 99.4 0.0 211 39-300 11-230 (320) 143 4JOQ_A ABC ribose transporter, 97.6 6.4E-08 4.6E-12 97.7 0.0 218 42-308 4-226 (297) 144 4JOQ_B ABC ribose transporter, 97.6 6.4E-08 4.6E-12 97.7 0.0 218 42-308 4-226 (297) 145 5HSG_A Putative ABC transporte 97.5 7E-08 5.1E-12 98.2 0.0 214 41-308 21-243 (310) 146 2O20_B Catabolite control prot 97.5 8.3E-08 6E-12 98.8 0.0 203 42-300 60-264 (332) 147 2O20_F Catabolite control prot 97.5 8.3E-08 6E-12 98.8 0.0 203 42-300 60-264 (332) 148 4YO7_A Sugar ABC transporter ( 97.5 8.5E-08 6.2E-12 98.4 0.0 216 40-308 40-261 (326) 149 6GQ0_A Putative sugar binding 97.5 9.5E-08 6.9E-12 97.6 0.0 220 35-308 20-246 (318) 150 6GT9_C Putative sugar binding 97.5 9.5E-08 6.9E-12 97.6 0.0 220 35-308 20-246 (318) 151 1GUB_A D-ALLOSE-BINDING PERIPL 97.5 1E-07 7.3E-12 95.6 0.0 218 45-308 1-226 (288) 152 1GUD_B D-ALLOSE-BINDING PERIPL 97.5 1E-07 7.3E-12 95.6 0.0 218 45-308 1-226 (288) 153 1DBQ_B PURINE REPRESSOR; TRANS 97.5 1.1E-07 7.8E-12 95.4 0.0 205 42-300 4-212 (289) 154 4RK0_D LacI family sugar-bindi 97.5 1.2E-07 8.7E-12 94.2 0.0 198 42-300 4-203 (274) 155 3DBI_A SUGAR-BINDING TRANSCRIP 97.4 1.3E-07 9.1E-12 97.6 0.0 207 42-300 58-267 (338) 156 3DBI_C SUGAR-BINDING TRANSCRIP 97.4 1.3E-07 9.1E-12 97.6 0.0 207 42-300 58-267 (338) 157 3EGC_F putative ribose operon 97.4 1.5E-07 1.1E-11 94.6 0.0 205 41-300 4-211 (291) 158 4KZK_A L-arabinose-binding pro 97.4 1.6E-07 1.1E-11 96.8 0.0 218 40-308 31-265 (337) 159 3O1I_C Sensor protein TorS (E. 97.4 1.6E-07 1.1E-11 95.1 0.0 216 43-308 3-226 (304) 160 3O1I_D Sensor protein TorS (E. 97.4 1.6E-07 1.1E-11 95.1 0.0 216 43-308 3-226 (304) 161 3O1J_C Sensor protein TorS (E. 97.4 1.6E-07 1.1E-11 95.1 0.0 216 43-308 3-226 (304) 162 4YHS_A ABC TRANSPORTER SOLUTE 97.4 1.6E-07 1.1E-11 97.7 0.0 215 40-308 53-276 (354) 163 3CLK_B Transcription regulator 97.4 1.6E-07 1.2E-11 94.3 0.0 205 41-300 4-210 (290) 164 2RGY_A Transcriptional regulat 97.4 1.6E-07 1.2E-11 94.2 0.0 208 41-300 4-214 (290) 165 6HB0_A ABC transporter peripla 97.4 1.8E-07 1.3E-11 95.7 0.0 211 39-300 13-232 (322) 166 1SXG_D Glucose-resistance amyl 97.4 1.8E-07 1.3E-11 93.2 0.0 204 42-300 5-212 (280) 167 2NZV_G Catabolite control prot 97.4 1.8E-07 1.3E-11 93.2 0.0 204 42-300 5-212 (280) 168 4RS3_A ABC transporter, carboh 97.4 1.9E-07 1.4E-11 95.7 0.0 213 40-308 7-226 (327) 169 5OCP_A Periplasmic binding pro 97.4 2E-07 1.5E-11 94.3 0.0 203 47-300 2-212 (302) 170 3BIL_A Probable LacI-family tr 97.4 2.1E-07 1.5E-11 96.4 0.0 202 42-300 63-266 (348) 171 3O74_A Fructose transport syst 97.3 2.3E-07 1.6E-11 91.9 0.0 200 45-300 2-205 (272) 172 3O74_B Fructose transport syst 97.3 2.3E-07 1.6E-11 91.9 0.0 200 45-300 2-205 (272) 173 4Z0N_A Periplasmic Solute Bind 97.3 2.3E-07 1.7E-11 95.6 0.0 222 40-309 26-265 (337) 174 4PE6_B solute binding protein; 97.3 2.3E-07 1.7E-11 95.8 0.0 210 40-299 13-228 (341) 175 2X7X_A SENSOR PROTEIN (E.C.2.7 97.3 2.4E-07 1.7E-11 95.0 0.0 213 42-308 3-221 (325) 176 2X7X_B SENSOR PROTEIN (E.C.2.7 97.3 2.4E-07 1.7E-11 95.0 0.0 213 42-308 3-221 (325) 177 4RXM_A Possible sugar ABC supe 97.3 2.4E-07 1.8E-11 92.9 0.0 205 43-300 2-213 (292) 178 2HSG_A Glucose-resistance amyl 97.3 2.5E-07 1.8E-11 95.1 0.0 204 42-300 57-264 (332) 179 1ZHH_A Autoinducer 2-binding p 97.3 2.5E-07 1.8E-11 95.7 0.0 220 42-308 42-268 (344) 180 5ULB_A Putative sugar ABC tran 97.3 2.6E-07 1.9E-11 95.1 0.0 217 38-308 12-237 (337) 181 2FEP_A Catabolite control prot 97.3 2.7E-07 1.9E-11 92.6 0.0 206 40-300 11-220 (289) 182 2IKS_A DNA-binding transcripti 97.3 2.7E-07 2E-11 92.6 0.0 204 41-300 16-222 (293) 183 3D8U_A PurR transcriptional re 97.3 2.7E-07 2E-11 91.5 0.0 202 44-300 2-206 (275) 184 3D8U_B PurR transcriptional re 97.3 2.7E-07 2E-11 91.5 0.0 202 44-300 2-206 (275) 185 1JHZ_B PURINE NUCLEOTIDE SYNTH 97.3 2.7E-07 2E-11 92.4 0.0 206 41-300 3-212 (289) 186 2P9H_A Lactose operon represso 97.3 2.8E-07 2.1E-11 91.0 0.0 199 46-300 1-202 (269) 187 2PAF_B Lactose operon represso 97.3 2.8E-07 2.1E-11 91.0 0.0 199 46-300 1-202 (269) 188 3K4H_A putative transcriptiona 97.3 2.9E-07 2.1E-11 92.4 0.0 210 42-300 5-217 (292) 189 4RXT_A Sugar ABC transporter; 97.3 3E-07 2.1E-11 92.8 0.0 213 43-308 2-226 (299) 190 4ZJP_A solute binding protein; 97.3 3E-07 2.2E-11 92.3 0.0 206 38-299 17-229 (292) 191 2VK2_A ABC TRANSPORTER PERIPLA 97.3 3.2E-07 2.3E-11 92.9 0.0 205 45-300 2-216 (306) 192 1JFT_A PURINE NUCLEOTIDE SYNTH 97.3 3.2E-07 2.3E-11 94.5 0.0 206 41-300 54-263 (340) 193 3BRS_B Periplasmic binding pro 97.3 3.3E-07 2.4E-11 91.8 0.0 215 43-308 3-223 (289) 194 4RK4_A Transcriptional regulat 97.3 3.4E-07 2.4E-11 91.3 0.0 205 41-300 5-216 (283) 195 4RK5_A Transcriptional regulat 97.3 3.4E-07 2.4E-11 91.3 0.0 205 41-300 5-216 (283) 196 2QU7_B Putative transcriptiona 97.3 3.6E-07 2.6E-11 91.5 0.0 200 42-300 5-212 (288) 197 4IRX_B Sugar ABC transporter, 97.3 3.7E-07 2.7E-11 91.8 0.0 208 41-300 4-219 (296) 198 4RY9_A Periplasmic binding pro 97.2 3.9E-07 2.8E-11 91.9 0.0 205 42-300 4-223 (302) 199 3G1W_A Sugar ABC transporter; 97.2 4E-07 2.9E-11 92.1 0.0 213 43-308 2-220 (305) 200 3G1W_B Sugar ABC transporter; 97.2 4E-07 2.9E-11 92.1 0.0 213 43-308 2-220 (305) 201 5XSD_B Periplasmic binding pro 97.2 4.3E-07 3.1E-11 91.9 0.0 217 40-309 13-235 (306) 202 5DKV_A ABC transporter substra 97.2 4.3E-07 3.1E-11 92.8 0.0 219 42-308 24-253 (324) 203 1ZVV_B Glucose-resistance amyl 97.2 4.3E-07 3.2E-11 93.1 0.0 204 42-300 57-264 (332) 204 4KQ9_A Ribose ABC transporter, 97.2 4.6E-07 3.3E-11 91.2 0.0 205 42-299 4-214 (299) 205 5XSS_A Periplasmic binding pro 97.2 4.8E-07 3.5E-11 92.1 0.0 217 39-308 22-244 (316) 206 4YR7_A LuxP; PROTEIN-LIGAND CO 97.2 5.1E-07 3.7E-11 93.2 0.0 222 42-308 43-269 (345) 207 2IOY_A Periplasmic sugar-bindi 97.2 5.3E-07 3.8E-11 90.0 0.0 208 46-308 2-215 (283) 208 1TLF_C TRYPTIC CORE FRAGMENT O 97.2 5.3E-07 3.8E-11 91.0 0.0 200 45-300 2-204 (301) 209 3OQO_C Catabolite control prot 97.2 5.3E-07 3.8E-11 92.8 0.0 204 42-300 57-264 (339) 210 4RK6_A Glucose-resistance amyl 97.2 5.4E-07 3.9E-11 90.0 0.0 205 40-300 5-214 (287) 211 4RK7_B Glucose-resistance amyl 97.2 5.4E-07 3.9E-11 90.0 0.0 205 40-300 5-214 (287) 212 4RWE_A Sugar-binding transport 97.2 6E-07 4.3E-11 90.0 0.0 213 43-308 3-220 (292) 213 3GV0_A Transcriptional regulat 97.2 6.1E-07 4.4E-11 89.8 0.0 207 41-300 4-213 (288) 214 5HKO_A ABC transporter, carboh 97.2 6.3E-07 4.6E-11 92.7 0.0 214 40-309 28-248 (348) 215 4RXU_A Periplasmic sugar-bindi 97.2 6.5E-07 4.7E-11 93.4 0.0 153 39-241 24-182 (367) 216 4KMR_A Transcriptional regulat 97.1 6.7E-07 4.9E-11 88.9 0.0 201 44-300 2-208 (280) 217 3L6U_A ABC-TYPE SUGAR TRANSPOR 97.1 6.8E-07 4.9E-11 89.7 0.0 205 42-300 5-220 (293) 218 2DRI_A D-RIBOSE-BINDING PROTEI 97.1 6.8E-07 4.9E-11 88.2 0.0 207 46-308 2-214 (271) 219 3D02_A Putative LACI-type tran 97.1 6.9E-07 5E-11 90.1 0.0 214 43-308 2-222 (303) 220 4WZZ_A ABC TRANSPORTER SOLUTE 97.1 7.2E-07 5.2E-11 93.2 0.0 215 41-308 50-273 (371) 221 1JX6_A LUXP PROTEIN; PROTEIN-L 97.1 7.2E-07 5.2E-11 91.9 0.0 222 42-308 40-266 (342) 222 4WT7_A ABC TRANSPORTER SOLUTE 97.1 7.7E-07 5.5E-11 90.8 0.0 202 42-299 29-242 (321) 223 2RJO_A Twin-arginine transloca 97.1 8.7E-07 6.3E-11 90.9 0.0 217 43-307 3-229 (332) 224 4Y9T_A ABC TRANSPORTER SOLUTE 97.1 8.9E-07 6.5E-11 91.4 0.0 205 42-300 24-239 (346) 225 4RU1_A Monosaccharide ABC tran 97.1 9.1E-07 6.6E-11 89.3 0.0 206 39-299 14-223 (304) 226 4YV7_A ABC TRANSPORTER SOLUTE 97.1 9.4E-07 6.8E-11 90.2 0.0 215 39-309 34-255 (326) 227 2FN9_B ribose ABC transporter, 97.1 1E-06 7.3E-11 88.2 0.0 202 45-299 2-215 (290) 228 4XXH_B PROTEIN (TREHALOSE OPER 97.1 1E-06 7.4E-11 86.1 0.0 192 45-299 2-196 (255) 229 5IX8_B Putative sugar ABC tran 97.0 1.1E-06 8.2E-11 89.4 0.0 208 40-299 10-224 (321) 230 4WUT_A ABC TRANSPORTER SOLUTE 97.0 1.1E-06 8.2E-11 89.0 0.0 222 39-308 17-244 (313) 231 3HCW_A Maltose operon transcri 97.0 1.2E-06 8.5E-11 88.0 0.0 207 42-299 4-216 (295) 232 1JYE_A Lactose Operon Represso 97.0 1.2E-06 9E-11 90.4 0.0 203 42-300 58-263 (349) 233 2PE5_B Lactose operon represso 97.0 1.3E-06 9.2E-11 89.4 0.0 203 42-300 57-262 (330) 234 3C3K_B Alanine racemase (E.C.5 97.0 1.3E-06 9.5E-11 87.1 0.0 203 41-300 4-209 (285) 235 8ABP_A L-ARABINOSE-BINDING PRO 97.0 1.3E-06 9.6E-11 88.1 0.0 214 45-308 2-231 (306) 236 5ABP_A L-ARABINOSE-BINDING PRO 97.0 1.3E-06 9.7E-11 88.1 0.0 214 45-308 2-231 (306) 237 4KVF_A Rhamnose ABC transporte 97.0 1.5E-06 1.1E-10 89.5 0.0 217 39-307 33-257 (342) 238 3EDC_D Lactose operon represso 97.0 1.5E-06 1.1E-10 90.2 0.0 204 41-300 57-263 (360) 239 3KJX_D Transcriptional regulat 97.0 1.6E-06 1.1E-10 89.4 0.0 204 42-300 65-272 (344) 240 3KJX_C Transcriptional regulat 97.0 1.6E-06 1.1E-10 89.4 0.0 204 42-300 65-272 (344) 241 1GLG_A GALACTOSE/GLUCOSE-BINDI 97.0 1.6E-06 1.1E-10 87.7 0.0 217 45-309 2-236 (309) 242 2FVY_A D-galactose-binding per 97.0 1.6E-06 1.1E-10 87.7 0.0 217 45-309 2-236 (309) 243 3M9W_A D-xylose-binding peripl 97.0 1.6E-06 1.2E-10 87.9 0.0 211 45-308 2-221 (313) 244 3MA0_A D-xylose-binding peripl 97.0 1.6E-06 1.2E-10 87.9 0.0 211 45-308 2-221 (313) 245 3MA0_C D-xylose-binding peripl 97.0 1.6E-06 1.2E-10 87.9 0.0 211 45-308 2-221 (313) 246 5IBQ_A Probable ribose ABC tra 97.0 1.6E-06 1.2E-10 87.8 0.0 217 38-308 17-239 (310) 247 3K9C_B Transcriptional regulat 97.0 1.7E-06 1.2E-10 86.5 0.0 201 41-300 8-210 (289) 248 4RY8_B Periplasmic binding pro 97.0 1.7E-06 1.3E-10 88.4 0.0 215 40-308 10-230 (329) 249 4RY8_C Periplasmic binding pro 97.0 1.7E-06 1.3E-10 88.4 0.0 215 40-308 10-230 (329) 250 3ROT_A ABC sugar transporter, 96.9 1.9E-06 1.4E-10 86.6 0.0 205 44-299 2-212 (297) 251 3ROT_B ABC sugar transporter, 96.9 1.9E-06 1.4E-10 86.6 0.0 205 44-299 2-212 (297) 252 5BRA_A Putative periplasmic bi 96.9 1.9E-06 1.4E-10 89.0 0.0 220 37-308 36-262 (350) 253 2H3H_A Sugar ABC transporter, 96.9 1.9E-06 1.4E-10 87.3 0.0 209 45-308 1-215 (313) 254 2H3H_B Sugar ABC transporter, 96.9 1.9E-06 1.4E-10 87.3 0.0 209 45-308 1-215 (313) 255 3GBV_A Putative LacI-family tr 96.9 1.9E-06 1.4E-10 86.8 0.0 155 42-242 5-168 (304) 256 3HUU_A Transcription regulator 96.9 2.3E-06 1.7E-10 86.2 0.0 205 41-299 18-226 (305) 257 3HUU_C Transcription regulator 96.9 2.3E-06 1.7E-10 86.2 0.0 205 41-299 18-226 (305) 258 3KKE_C LacI family Transcripti 96.9 2.5E-06 1.8E-10 85.9 0.0 205 40-300 10-222 (303) 259 3KKE_B LacI family Transcripti 96.9 2.5E-06 1.8E-10 85.9 0.0 205 40-300 10-222 (303) 260 3BBL_A Regulatory protein of L 96.9 2.6E-06 1.9E-10 84.9 0.0 146 145-300 63-213 (287) 261 4PZ0_A sugar ABC transporter, 96.9 2.8E-06 2E-10 86.6 0.0 213 41-307 6-227 (324) 262 4YS6_A ABC TRANSPORTER SOLUTE 96.8 2.8E-06 2E-10 88.1 0.0 217 40-307 31-270 (360) 263 3L49_C ABC sugar (Ribose) tran 96.8 2.9E-06 2.1E-10 84.7 0.0 203 43-299 3-215 (291) 264 3JY6_A Transcriptional regulat 96.8 3E-06 2.1E-10 84.0 0.0 199 42-300 4-206 (276) 265 3JY6_D Transcriptional regulat 96.8 3E-06 2.1E-10 84.0 0.0 199 42-300 4-206 (276) 266 5HQJ_A Periplasmic binding pro 96.8 3E-06 2.2E-10 85.7 0.0 204 40-297 23-232 (311) 267 3EJW_A SmLsrB; Periplasmic bin 96.8 3.3E-06 2.4E-10 85.6 0.0 211 45-308 1-220 (315) 268 3QK7_C Transcriptional regulat 96.8 3.3E-06 2.4E-10 84.5 0.0 207 42-300 3-212 (294) 269 3E3M_D Transcriptional regulat 96.8 3.3E-06 2.4E-10 87.3 0.0 204 42-300 67-275 (355) 270 2WRZ_A L-ARABINOSE-BINDING PER 96.8 3.5E-06 2.5E-10 84.9 0.0 206 45-300 2-222 (306) 271 5BQ3_A Rhamnose ABC transporte 96.8 3.7E-06 2.7E-10 85.9 0.0 218 39-308 21-248 (332) 272 4RY0_A Probable ribose ABC tra 96.8 3.9E-06 2.8E-10 83.6 0.0 211 44-308 2-218 (289) 273 3TB6_A Arabinose metabolism tr 96.7 4.4E-06 3.2E-10 83.7 0.0 206 41-300 11-226 (298) 274 3GYB_A Transcriptional regulat 96.7 5.4E-06 3.9E-10 82.2 0.0 198 43-300 3-201 (280) 275 3GYB_B Transcriptional regulat 96.7 5.4E-06 3.9E-10 82.2 0.0 198 43-300 3-201 (280) 276 5UFH_A LacI-type transcription 96.7 5.9E-06 4.3E-10 85.0 0.0 202 43-300 63-278 (347) 277 3CTP_A Periplasmic binding pro 96.7 6E-06 4.3E-10 84.3 0.0 198 42-300 57-256 (330) 278 3G85_A Transcriptional regulat 96.7 6E-06 4.3E-10 82.3 0.0 204 41-300 7-213 (289) 279 3H5O_B Transcriptional regulat 96.7 6.1E-06 4.4E-10 84.6 0.0 203 42-300 59-264 (339) 280 5YSZ_A Transcriptional regulat 96.6 7.5E-06 5.4E-10 84.8 0.0 148 145-300 143-293 (360) 281 3MIZ_A Putative transcriptiona 96.6 8.6E-06 6.2E-10 81.7 0.0 206 41-300 9-222 (301) 282 1TJY_A sugar transport protein 96.6 9.4E-06 6.8E-10 82.2 0.0 210 44-308 2-221 (316) 283 4O5A_A LacI family transcripti 96.5 9.7E-06 7E-10 83.2 0.0 207 42-300 65-274 (345) 284 3UUG_B Multiple sugar-binding 96.5 1.2E-05 8.5E-10 82.0 0.0 206 44-300 2-229 (330) 285 3LKV_A uncharacterized CONSERV 96.5 1.3E-05 9.7E-10 80.1 0.0 215 41-308 4-226 (302) 286 4KQC_A Periplasmic binding pro 96.4 1.8E-05 1.3E-09 80.1 0.0 209 43-299 2-229 (319) 287 4WWH_A ABC TRANSPORTER SOLUTE 96.4 1.8E-05 1.3E-09 81.9 0.0 210 40-300 30-261 (362) 288 3CS3_A Sugar-binding transcrip 96.4 1.8E-05 1.3E-09 78.0 0.0 194 42-300 5-202 (277) 289 2H0A_A Transcriptional regulat 96.3 2.4E-05 1.7E-09 77.0 0.0 144 145-300 54-205 (276) 290 3E61_B Putative transcriptiona 96.3 2.5E-05 1.8E-09 77.0 0.0 197 41-300 4-202 (277) 291 3E61_A Putative transcriptiona 96.3 2.5E-05 1.8E-09 77.0 0.0 197 41-300 4-202 (277) 292 6HNI_A ABC-type transport syst 96.2 3.4E-05 2.4E-09 77.9 0.0 218 39-307 17-240 (319) 293 6HNJ_A ABC-type transport syst 96.2 3.4E-05 2.4E-09 77.9 0.0 218 39-307 17-240 (319) 294 3H75_A Periplasmic sugar-bindi 96.2 3.8E-05 2.7E-09 78.9 0.0 212 44-300 2-230 (350) 295 4RKQ_A Transcriptional regulat 96.1 4.6E-05 3.3E-09 75.8 0.0 199 40-300 10-216 (294) 296 4RKQ_B Transcriptional regulat 96.1 4.6E-05 3.3E-09 75.8 0.0 199 40-300 10-216 (294) 297 3LFT_A uncharacterized protein 96.0 5.4E-05 3.9E-09 75.1 0.0 202 45-298 2-209 (295) 298 3LFT_B uncharacterized protein 96.0 5.4E-05 3.9E-09 75.1 0.0 202 45-298 2-209 (295) 299 3HS3_B Ribose operon repressor 95.7 0.00012 8.5E-09 72.0 0.0 195 41-300 6-203 (277) 300 3JVD_A Transcriptional regulat 95.7 0.00012 8.9E-09 74.1 0.0 192 43-299 62-255 (333) 301 3JVD_B Transcriptional regulat 95.7 0.00012 8.9E-09 74.1 0.0 192 43-299 62-255 (333) 302 3S99_A Basic membrane lipoprot 95.7 0.00014 9.8E-09 74.7 0.0 216 27-298 9-229 (356) 303 6DSP_B Autoinducer 2-binding p 95.3 0.00028 2E-08 71.9 0.0 221 38-308 14-250 (347) 304 2FQW_A Membrane lipoprotein tm 95.3 0.0003 2.2E-08 70.6 0.0 146 145-300 61-213 (318) 305 2FQX_A Membrane lipoprotein tm 95.3 0.0003 2.2E-08 70.6 0.0 146 145-300 61-213 (318) 306 2FQY_A Membrane lipoprotein tm 95.3 0.0003 2.2E-08 70.6 0.0 146 145-300 61-213 (318) 307 3H5T_A Transcriptional regulat 95.0 0.00053 3.8E-08 70.4 0.0 146 145-300 127-293 (366) 308 6NDI_A Hypothetical Protein CD 94.9 0.00064 4.6E-08 68.6 0.0 144 145-299 119-269 (334) 309 6NDI_B Hypothetical Protein CD 94.9 0.00064 4.6E-08 68.6 0.0 144 145-299 119-269 (334) 310 4IIL_A Membrane lipoprotein Tp 94.8 0.00072 5.2E-08 68.7 0.0 212 40-299 27-252 (346) 311 6PI6_C Atrazine periplasmic bi 94.8 0.00074 5.3E-08 68.9 0.0 206 38-298 17-227 (355) 312 6PII_A Atrazine periplasmic bi 94.8 0.00074 5.3E-08 68.9 0.0 206 38-298 17-227 (355) 313 6RQG_A 46 kDa surface antigen; 94.7 0.00085 6.1E-08 69.0 0.0 92 145-241 76-195 (387) 314 6RUX_C Surface antigen P46; im 94.7 0.00085 6.1E-08 69.0 0.0 92 145-241 76-195 (387) 315 6S3T_T 46 kDa surface antigen, 94.7 0.00085 6.1E-08 69.0 0.0 92 145-241 76-195 (387) 316 4FE4_A Xylose operon regulator 94.6 0.00092 6.7E-08 69.2 0.0 148 145-300 55-208 (392) 317 4FE7_A Xylose operon regulator 94.4 0.0012 8.7E-08 68.9 0.0 205 38-300 18-228 (412) 318 2HQB_A Transcriptional activat 93.5 0.0031 2.3E-07 62.0 0.0 140 145-298 62-204 (296) 319 6SHU_A Basic membrane protein 93.3 0.0039 2.8E-07 63.5 0.0 205 41-298 43-252 (361) 320 4P98_A Basic membrane lipoprot 91.8 0.01 7.4E-07 58.8 0.0 133 145-283 74-210 (317) 321 4PEV_C solute binding protein; 90.2 0.022 1.6E-06 58.9 0.0 145 145-299 110-271 (422) 322 5ER3_A Sugar ABC transporter, 89.0 0.032 2.3E-06 55.7 0.0 91 145-242 237-332 (341) 323 3QI7_A Putative transcriptiona 87.1 0.055 4E-06 54.7 0.0 152 145-300 86-250 (371) 324 6U1N_R Muscarinic acetylcholin 78.8 0.23 1.6E-05 52.2 0.0 34 644-677 99-133 (509) 325 2Z73_A Rhodopsin; Visual pigme 72.8 0.44 3.2E-05 48.8 0.0 33 645-677 105-138 (448) 326 3AYN_A Rhodopsin; transmembran 72.8 0.44 3.2E-05 48.8 0.0 33 645-677 105-138 (448) 327 6P9X_R Guanine nucleotide-bind 69.6 0.58 4.2E-05 47.7 0.0 27 644-670 177-203 (427) 328 5X33_A LTB4 receptor,Lysozyme, 69.1 0.61 4.4E-05 49.0 0.0 18 644-661 87-104 (523) 329 5XSZ_A Lysophosphatidic acid r 67.4 0.7 5E-05 47.6 0.0 34 644-677 96-130 (477) 330 4PXZ_A P2Y purinoceptor 12, So 67.2 0.71 5.1E-05 47.3 0.0 34 644-677 102-136 (466) 331 6IGK_A Endothelin receptor typ 65.7 0.8 5.8E-05 47.5 0.0 34 644-677 108-142 (498) 332 3ODU_A C-X-C chemokine recepto 65.5 0.8 5.8E-05 47.6 0.0 34 644-677 115-149 (502) 333 5T04_A Neurotensin receptor ty 65.0 0.84 6.1E-05 47.6 0.0 16 645-660 107-122 (513) 334 3ODU_B C-X-C chemokine recepto 65.0 0.84 6.1E-05 47.4 0.0 35 644-678 115-150 (502) 335 3OE0_A C-X-C chemokine recepto 61.9 1 7.6E-05 46.5 0.0 34 644-677 115-149 (499) 336 5T1A_A C-C chemokine receptor 60.9 1.1 8.2E-05 46.5 0.0 34 644-677 119-153 (508) 337 6K41_R Guanine nucleotide-bind 60.4 1.2 8.4E-05 46.6 0.0 34 644-677 280-314 (512) 338 6K42_R Guanine nucleotide-bind 60.4 1.2 8.4E-05 46.6 0.0 34 644-677 280-314 (512) 339 5YC8_A Muscarinic acetylcholin 60.1 1.2 8.6E-05 44.6 0.0 18 644-661 94-111 (421) 340 6N4B_R Guanine nucleotide-bind 59.8 1.2 8.8E-05 46.2 0.0 18 587-604 138-155 (495) 341 3VW7_A Chimera of Proteinase-a 59.5 1.2 9E-05 45.6 0.0 34 644-677 89-123 (484) 342 6GPS_A C-C chemokine receptor 59.5 1.2 9E-05 44.6 0.0 23 644-666 108-130 (429) 343 6ME8_A Soluble cytochrome b562 59.0 1.3 9.3E-05 45.2 0.0 26 644-669 185-210 (460) 344 6ME6_A Soluble cytochrome b562 58.3 1.3 9.7E-05 45.1 0.0 34 644-677 185-219 (460) 345 4GRV_A Neurotensin receptor ty 58.1 1.4 9.8E-05 45.8 0.0 33 645-677 107-140 (510) 346 6WWZ_R Guanine nucleotide-bind 57.9 1.4 0.0001 46.3 0.0 33 644-676 259-292 (529) 347 5ZKC_A Muscarinic acetylcholin 57.5 1.4 0.0001 44.0 0.0 34 644-677 94-128 (421) 348 5IU7_A Adenosine receptor A2a, 57.2 1.4 0.0001 44.2 0.0 17 644-660 82-98 (433) 349 5NM4_A Lysozyme C (E.C.3.2.1.1 57.1 1.4 0.0001 44.2 0.0 17 644-660 82-98 (433) 350 5WIU_A D(4) dopamine receptor, 56.4 1.5 0.00011 43.9 0.0 22 644-665 108-129 (422) 351 5WIV_A D(4) dopamine receptor, 56.4 1.5 0.00011 43.9 0.0 22 644-665 108-129 (422) 352 5NDD_A Lysozyme,Proteinase-act 56.3 1.5 0.00011 46.9 0.0 34 644-677 273-307 (619) 353 4IB4_A Human 5-HT2B receptor_B 56.2 1.5 0.00011 43.9 0.0 34 644-677 99-133 (430) 354 6AK3_A Prostaglandin E2 recept 55.3 1.6 0.00012 43.5 0.0 19 644-662 88-106 (418) 355 6AK3_B Prostaglandin E2 recept 55.3 1.6 0.00012 43.5 0.0 19 644-662 88-106 (418) 356 6M9T_A Prostaglandin E2 recept 54.9 1.7 0.00012 45.6 0.0 17 645-661 139-155 (537) 357 5ZKP_A Platelet-activating fac 54.8 1.7 0.00012 44.2 0.0 34 644-677 88-122 (466) 358 5ZKQ_A Platelet-activating fac 54.6 1.7 0.00012 43.7 0.0 18 644-661 88-105 (438) 359 5W0P_C T4 lysozyme-human rhodo 54.4 1.7 0.00012 49.2 0.0 21 644-664 266-286 (906) 360 5W0P_B T4 lysozyme-human rhodo 54.0 1.8 0.00013 49.1 0.0 23 644-666 266-288 (906) 361 6OSA_R Neurotensin receptor ty 53.5 1.8 0.00013 43.5 0.0 16 645-660 158-173 (435) 362 4U14_A Muscarinic acetylcholin 52.9 1.9 0.00014 43.9 0.0 22 644-665 81-102 (460) 363 5TUD_A Chimera protein of 5-hy 52.5 1.9 0.00014 43.7 0.0 34 644-677 115-149 (457) 364 6C1R_B C5a anaphylatoxin chemo 52.2 2 0.00014 43.1 0.0 34 644-677 191-225 (422) 365 6OL9_A Muscarinic acetylcholin 52.1 2 0.00014 44.0 0.0 16 644-659 81-96 (480) 366 6LI0_A G-protein coupled recep 52.1 2 0.00014 43.8 0.0 34 644-677 95-129 (468) 367 4XES_A neurotensin receptor su 51.2 2.1 0.00015 44.6 0.0 33 645-677 107-140 (541) 368 6C1Q_B C5a anaphylatoxin chemo 51.0 2.1 0.00015 42.9 0.0 34 644-677 191-225 (422) 369 3V2Y_A Sphingosine 1-phosphate 50.5 2.2 0.00016 44.4 0.0 33 645-677 132-165 (520) 370 5UIW_A C-C chemokine receptor 50.3 2.2 0.00016 42.2 0.0 19 644-662 99-117 (411) 371 5OLZ_A Adenosine receptor A2a, 50.0 2.3 0.00016 42.6 0.0 16 645-660 84-99 (434) 372 6P9Y_R Guanine nucleotide-bind 49.7 2.3 0.00017 43.8 0.0 30 645-674 219-248 (483) 373 6MXT_A Fusion protein of Lysoz 49.3 2.4 0.00017 43.4 0.0 34 644-677 237-271 (472) 374 6KUX_A alpha2A adrenergic rece 48.9 2.4 0.00017 41.7 0.0 18 644-661 83-100 (395) 375 4U15_B M3-mT4L, Tiotropium; GP 48.4 2.5 0.00018 42.1 0.0 18 644-661 81-98 (418) 376 3EML_A Human Adenosine A2A rec 48.3 2.5 0.00018 43.3 0.0 15 644-658 88-102 (488) 377 6ORV_RP Guanine nucleotide-bin 48.2 2.5 0.00018 43.6 0.0 34 644-677 231-264 (491) 378 3PBL_A D(3) dopamine receptor; 47.8 2.6 0.00019 43.1 0.0 33 645-677 109-142 (481) 379 6CMO_R Soluble cytochrome b562 47.5 2.6 0.00019 42.9 0.0 34 644-677 246-280 (463) 380 6B3J_R Guanine nucleotide-bind 46.4 2.8 0.0002 43.2 0.0 34 644-677 231-264 (491) 381 4LDE_A Lysozyme, Beta-2 adrene 45.1 3 0.00022 42.4 0.0 33 644-676 251-284 (469) 382 5WF5_A Human A2a adenosine rec 44.9 3.1 0.00022 43.0 0.0 13 645-657 105-117 (504) 383 2R4R_A Beta-2 adrenergic recep 44.8 3.1 0.00022 40.1 0.0 17 644-660 102-118 (365) 384 5TGZ_A Cannabinoid receptor 1, 44.8 3.1 0.00022 42.0 0.0 20 585-604 27-46 (452) 385 3RZE_A Histamine H1 receptor/L 44.7 3.1 0.00022 42.0 0.0 18 644-661 77-94 (452) 386 6MEO_B Envelope glycoprotein g 44.7 3.1 0.00023 39.0 0.0 18 644-661 97-114 (313) 387 4ZUD_A Chimera protein of Solu 44.5 3.1 0.00023 41.1 0.0 22 644-665 192-213 (410) 388 4IAR_A Chimera protein of huma 44.4 3.2 0.00023 40.9 0.0 17 644-660 89-105 (401) 389 6D26_A Prostaglandin D2 recept 44.1 3.2 0.00023 42.0 0.0 33 645-677 102-135 (470) 390 6D27_A Prostaglandin D2 recept 44.1 3.2 0.00023 42.0 0.0 33 645-677 102-135 (470) 391 6A93_A 5-hydroxytryptamine rec 43.8 3.3 0.00024 40.2 0.0 18 644-661 78-95 (376) 392 6A94_A 5-hydroxytryptamine rec 43.8 3.3 0.00024 40.2 0.0 18 644-661 78-95 (376) 393 4IAQ_A 5-hydroxytryptamine rec 43.2 3.4 0.00025 40.6 0.0 18 644-661 89-106 (403) 394 6KPG_R Guanine nucleotide-bind 42.9 3.5 0.00025 41.9 0.0 18 586-603 166-183 (469) 395 4MQS_A Muscarinic acetylcholin 42.4 3.5 0.00026 39.4 0.0 18 644-661 109-126 (351) 396 4DJH_B Kappa-type opioid recep 42.3 3.6 0.00026 41.8 0.0 19 644-662 90-108 (480) 397 6OS0_A Type-1 angiotensin II r 42.3 3.6 0.00026 40.8 0.0 34 644-677 104-138 (425) 398 6OS1_A Type-1 angiotensin II r 42.3 3.6 0.00026 40.8 0.0 34 644-677 104-138 (425) 399 6OS2_A Type-1 angiotensin II r 42.3 3.6 0.00026 40.8 0.0 34 644-677 104-138 (425) 400 4YAY_A human Angiotensin Recep 41.9 3.7 0.00027 40.6 0.0 25 644-668 192-216 (414) 401 4N6H_A Soluble cytochrome b562 41.6 3.7 0.00027 40.6 0.0 34 644-677 193-227 (414) 402 6AKX_B Neuropeptide Y receptor 41.4 3.8 0.00027 39.8 0.0 22 644-665 99-120 (381) 403 6D9H_R Guanine nucleotide-bind 40.8 3.9 0.00028 40.0 0.0 16 645-660 132-147 (389) 404 6RZ4_A Cysteinyl leukotriene r 39.9 4.1 0.0003 40.3 0.0 35 644-678 95-130 (423) 405 6RZ5_B Cysteinyl leukotriene r 39.9 4.1 0.0003 40.3 0.0 35 644-678 95-130 (423) 406 5TVN_A 5-hydroxytryptamine rec 39.9 4.1 0.0003 39.9 0.0 34 644-677 84-118 (402) 407 5UZ7_R Guanine nucleotide-bind 39.5 4.3 0.00031 41.9 0.0 27 645-671 224-250 (501) 408 6I9K_A Kumopsin1; Rhodopsin, G 39.0 4.4 0.00032 39.3 0.0 17 645-661 120-136 (380) 409 4XNV_A P2Y purinoceptor 1, Rub 38.7 4.5 0.00032 40.0 0.0 33 645-677 120-153 (421) 410 4XNW_C P2Y purinoceptor 1, Rub 38.7 4.5 0.00032 40.0 0.0 33 645-677 120-153 (421) 411 5WB1_A Envelope protein US28,n 38.1 4.6 0.00033 40.6 0.0 34 644-677 108-142 (458) 412 6LI1_A G-protein coupled recep 38.1 4.6 0.00033 40.5 0.0 34 644-677 95-129 (449) 413 5UNG_B Soluble cytochrome b562 38.1 4.6 0.00033 39.7 0.0 33 644-676 189-222 (411) 414 5UNF_A Soluble cytochrome b562 37.9 4.7 0.00034 39.7 0.0 25 644-668 189-213 (411) 415 6J21_A Substance-P receptor (E 37.8 4.7 0.00034 40.1 0.0 34 644-677 100-134 (441) 416 5ZHP_A Muscarinic acetylcholin 37.7 4.7 0.00034 39.8 0.0 17 644-660 81-97 (418) 417 5NJ6_A Lysozyme,Proteinase-act 37.6 4.7 0.00034 40.1 0.0 34 644-677 91-125 (437) 418 5DSG_B Muscarinic acetylcholin 37.3 4.8 0.00035 39.8 0.0 17 644-660 82-98 (422) 419 4Z36_A Lysophosphatidic Acid R 37.2 4.9 0.00035 40.6 0.0 34 645-678 136-170 (459) 420 6PT0_R Cannabinoid receptor 2, 37.0 4.9 0.00036 38.7 0.0 12 645-656 103-114 (369) 421 6OIJ_R Guanine nucleotide-bind 36.5 5.1 0.00037 38.4 0.0 34 644-677 103-137 (363) 422 4Z35_A Lysophosphatidic Acid R 36.4 5.1 0.00037 40.5 0.0 14 645-658 136-149 (464) 423 6KR8_A beta 2 adrenergic recep 36.4 5.1 0.00037 37.8 0.0 34 644-677 79-113 (336) 424 6IIU_A Soluble cytochrome b562 36.2 5.2 0.00037 40.6 0.0 24 585-608 136-159 (484) 425 6IIV_A Soluble cytochrome b562 36.2 5.2 0.00037 40.6 0.0 24 585-608 136-159 (484) 426 6E3Y_R Calcitonin gene-related 36.1 5.2 0.00038 41.0 0.0 25 644-668 218-242 (490) 427 6UUN_R Guanine nucleotide-bind 36.1 5.2 0.00038 41.0 0.0 25 644-668 218-242 (490) 428 6M1I_A Ribonuclease 3 (E.C.3.1 35.5 5.4 0.00039 39.5 0.0 28 644-671 184-211 (406) 429 4XT1_A US28, CX3CL1, nanobody 35.4 5.4 0.00039 38.3 0.0 35 644-678 108-143 (362) 430 6LW5_A N-formyl peptide recept 35.2 5.5 0.0004 39.6 0.0 18 645-662 200-217 (427) 431 5VBL_B agonist peptide,Rubredo 34.9 5.6 0.00041 39.0 0.0 34 644-677 116-150 (407) 432 5V54_B OB-1 fused 5-HT1b recep 34.7 5.7 0.00041 38.7 0.0 34 644-677 82-116 (395) 433 5WB2_A Envelope protein US28,n 34.2 5.8 0.00042 39.8 0.0 34 644-677 107-141 (460) 434 6IBB_A Succinate receptor 1, N 33.2 6.2 0.00045 37.3 0.0 34 644-677 94-128 (342) 435 4GBR_A Beta-2 adrenergic recep 33.0 6.3 0.00046 36.4 0.0 17 644-660 74-90 (309) 436 6NBF_R Parathyroid hormone/par 32.2 6.7 0.00048 40.0 0.0 29 646-674 253-281 (478) 437 6NBH_R Parathyroid hormone/par 32.2 6.7 0.00048 40.0 0.0 29 646-674 253-281 (478) 438 6LML_R Guanine nucleotide-bind 31.9 6.8 0.00049 39.1 0.0 34 645-678 195-228 (422) 439 6WHC_R Guanine nucleotide-bind 31.8 6.8 0.00049 39.9 0.0 34 645-678 221-254 (477) 440 6LI2_A G-protein coupled recep 31.7 6.8 0.0005 37.6 0.0 34 644-677 95-129 (372) 441 4L6R_A Soluble cytochrome b562 31.2 7.1 0.00051 39.0 0.0 34 645-678 205-238 (425) 442 6KUW_A Alpha-2C adrenergic rec 31.1 7.1 0.00052 39.7 0.0 17 644-660 92-108 (496) 443 4WW3_A BOG; Animals, Decapodif 30.8 7.2 0.00052 36.9 0.0 17 644-660 96-112 (350) 444 6J20_A Substance-P receptor,En 30.6 7.3 0.00053 38.6 0.0 34 644-677 100-134 (441) 445 5YWY_A Prostaglandin E2 recept 30.6 7.3 0.00053 36.5 0.0 34 644-677 88-122 (332) 446 4JKV_A Soluble cytochrome b562 30.3 7.5 0.00054 39.5 0.0 34 644-677 230-263 (475) 447 4N4W_A Smoothened homolog; Hum 30.3 7.5 0.00054 39.5 0.0 34 644-677 230-263 (475) 448 6FJ3_A Parathyroid hormone/par 30.2 7.5 0.00054 41.0 0.0 33 646-678 214-246 (602) 449 5ZBH_A Neuropeptide Y receptor 29.8 7.7 0.00056 39.8 0.0 17 644-660 118-134 (527) 450 6NIY_R Adenosine receptor A1,S 29.6 7.9 0.00057 39.3 0.0 27 645-671 216-242 (474) 451 5XJM_A Type-2 angiotensin II r 29.0 8.1 0.00059 37.9 0.0 34 644-677 80-114 (422) 452 6VMS_R Guanine nucleotide-bind 28.9 8.2 0.00059 38.6 0.0 16 645-660 245-260 (450) 453 6PS2_A Fusion protein of Beta- 28.3 8.5 0.00062 39.4 0.0 34 644-677 126-160 (506) 454 6PB0_R Corticotropin-releasing 28.3 8.6 0.00062 37.3 0.0 28 644-671 161-188 (375) 455 3PDS_A Fusion protein Beta-2 a 28.1 8.7 0.00063 38.5 0.0 33 645-677 79-112 (458) 456 5UEN_B Adenosine receptor A1,S 27.5 9 0.00065 37.5 0.0 16 645-660 78-93 (416) 457 5ZBQ_A Neuropeptide Y Y1 recep 27.3 9.1 0.00066 39.2 0.0 20 644-663 108-127 (525) 458 6RNK_A Succinate receptor 1, N 27.3 9.1 0.00066 36.0 0.0 34 644-677 94-128 (342) 459 5UEN_A Adenosine receptor A1,S 27.1 9.2 0.00067 37.4 0.0 16 645-660 78-93 (416) 460 6PB1_P Corticotropin-releasing 26.9 9.4 0.00068 37.3 0.0 33 644-676 179-211 (387) 461 6OMM_R N-formyl peptide recept 26.6 9.6 0.0007 36.2 0.0 16 645-660 116-131 (363) 462 5N2S_A Adenosine receptor A2a, 26.3 9.8 0.00071 37.6 0.0 15 645-659 184-198 (436) 463 5LWE_A C-C chemokine receptor 25.1 11 0.00077 35.3 0.0 20 644-663 93-112 (331) 464 5ZTY_A G protein coupled recep 24.4 11 0.00081 38.3 0.0 20 585-604 37-56 (500) 465 2KSA_A Substance-P receptor, S 23.6 12 0.00086 35.5 0.0 16 645-660 102-117 (364) 466 5LWE_B C-C chemokine receptor 23.4 12 0.00087 34.9 0.0 18 644-661 93-110 (331) 467 5DHG_B Nociceptin receptor-Cyt 23.4 12 0.00087 36.7 0.0 34 644-677 193-227 (424) 468 5DHH_B GPCR-BRIL Chimera; Noci 23.4 12 0.00087 36.7 0.0 34 644-677 193-227 (424) 469 4DKL_A Mu-type opioid receptor 20.3 15 0.0011 36.5 0.0 17 644-660 85-101 (464) 470 5NX2_A Glucagon-like peptide 1 20.1 16 0.0011 36.1 0.0 33 645-677 204-236 (422) 471 6LN2_A Glucagon-like peptide 1 20.1 16 0.0011 36.9 0.0 35 644-678 199-233 (469) No 1 >6N4X_A Metabotropic glutamate receptor 5; Cell Surface Receptor, MEMBRANE PROTEIN; HET: NAG; 4.0A {Homo sapiens} Probab=100.00 E-value=2.5e-77 Score=724.04 Aligned_cols=801 Identities=44% Similarity=0.813 Sum_probs=331.4 Template_Neff=10.300 Q NP_000836.2 35 EYAHSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDT 110 (908) Q Consensus 35 ~~~~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~ 110 (908) ........+++++||+++|.++... ....|+......+....+|+++|++++|+++++++|+++++.+.|+++++. T Consensus 30 ~~~~~~~~~~~i~Ig~l~p~~~~~~~~~~~~~~C~~~~~~~g~~~~~a~~~Av~~iN~~~~~lp~~~l~~~i~Dt~~~~~ 109 (877) T 6N4X_A 30 ERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSA 109 (877) T ss_dssp CCCCCEEECCSEEEEEEECCBCCCCSGGGTTTCCCSBCCCCCCCHHHHHHHHHHHHHHCSSSSTTCCEEEEEEECTTSHH T ss_pred CceEEEEeCCCEEEEEEEecccCCCcccccccCccchhhccCHHHHHHHHHHHHHHhcCCCCCCCCeeeeEEecCCCCHH Confidence 3444567889999999999987421 124566444445677899999999999998888889999999999998866 Q NP_000836.2 111 YALEQSLTFVQALIEK---DASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNT 187 (908) Q Consensus 111 ~a~~~~~~~~~~l~~~---~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~ 187 (908) .+.+.+.+++.+.... ......|...++.+....+++++++|+.++..+..++.++...++|++++.++++.++++. T Consensus 110 ~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~aviG~~~s~~~~~~a~~~~~~~ip~is~~~~s~~ls~~~ 189 (877) T 6N4X_A 110 VALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKT 189 (877) T ss_dssp HHHHHHHHHHHHHHHC--------------------CCCEEEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTT T ss_pred HHHHHHHHHHHhhcCCccccccceeccCCCCcccCCCCCeEEEECCCCcHHHHHHHHHHHHhCCCeEeecCCCcccCCcc Confidence 5555544443321000 0000000000000001124788999998888878888899999999999988877776655 Q NP_000836.2 188 RYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIK 267 (908) Q Consensus 188 ~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~ 267 (908) .+++++++.|++..+++++++++++++|++|++++++++++....+.+++.+++. ++++.....+..+....++...++ T Consensus 190 ~~p~~~r~~p~~~~~~~al~~~l~~~~w~~v~ii~~~~~~g~~~~~~~~~~~~~~-gi~i~~~~~~~~~~~~~~~~~~l~ 268 (877) T 6N4X_A 190 LFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKE-GICIAHSYKIYSNAGEQSFDKLLK 268 (877) T ss_dssp TSTTEEESSCCHHHHHHHHHHHHHHTTCCEEEEEECTTTTHHHHHHHHHHHHHHH-TCEEEEEEECCSSCCSSHHHHHHH T ss_pred ccCccccCCCCHHHHHHHHHHHHHHcCCcEEEEEEeCCcchHHHHHHHHHHHHHc-CcEEEEEEEecccCChHHHHHHHH Confidence 6899999999999999999999999999999999987788888888888888775 466543322221112234556666 Q NP_000836.2 268 RLLE-TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFR 346 (908) Q Consensus 268 ~l~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~ 346 (908) ++++ ..++++|++......+..+++++++.|+.+++.|++.+.|...............+.+.+.......+.|..++. T Consensus 269 ~l~~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~f~~~~~ 348 (877) T 6N4X_A 269 KLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYL 348 (877) T ss_dssp HHHTTTTTCCEEEEECCHHHHHHHHHHHHHTTCSSCSEEEECGGGSSCHHHHTTCHHHHTTCEEEEECCCCCHHHHHHHT T ss_pred HHHhcCCCceEEEEECChhhHHHHHHHHHHhCCCCcEEEEEecccccCccccCCcccccccceeeeeeCCCCCcHHHHHH Confidence 6653 126677777766667888999998888754456777665543221100011122333333322222333433332 Q NP_000836.2 347 SRTLANNRRNVWFAEFWEENFGCKLGSHGKR-NSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 347 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) ...+.....+.++.++|++.+++........ ..+...|+....... ......++.++|||++++++|++++....+. T Consensus 349 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~yDAv~~~a~al~~~~~~~~~ 426 (877) T 6N4X_A 349 KLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKT--HHVQDSKMGFVINAIYSMAYGLHNMQMSLCP 426 (877) T ss_dssp TCCTTTCCSSTTHHHHHHHHTTCCCTTSTTCCSSCCSCCCTTCCTTT--TCCCCTTHHHHHHHHHHHHHHHHHHHHHHSS T ss_pred hcCcccCCCChHHHHHHHHHcCCcCCCCCccccCCccccCCcceecc--cccccchHHHHHHHHHHHHHHHHHHHhccCC Confidence 2211112234566777776655432110000 001112322211100 0112346778999999999999998764332 Q NP_000836.2 426 GYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTP-VTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVEDM 502 (908) Q Consensus 426 ~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~-v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~~i 502 (908) .....|......++..+.+.+++.+|+|.+| + ++||++|++...+.+.+++..+ +...++.||.|+... .++ ..+ T Consensus 427 ~~~~~c~~~~~~~~~~l~~~l~~~~f~G~tG-~~v~Fd~~G~~~~~~~I~~~~~~~~~~~~~~~Vg~~~~~~l~~~-~~~ 504 (877) T 6N4X_A 427 GYAGLCDAMKPIDGRKLLESLMKTNFTGVSG-DTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD-DDE 504 (877) T ss_dssp SCSSCCSSSSSCCHHHHHHHHHHCEEECTTS-CEEECCTTSCCCCEEEEEEEEECSSSCEEEEEEEEEETTEEEEC-HHH T ss_pred CCCCCccccCCCCHHHHHHHHhcCeeecCCC-CEEEeCCCCCCCceeEEEEEEEeCCCeEEEEEEEEEeCCceEec-ccc Confidence 2112232212234556778888889999988 6 9999999998889999987532 123578999998652 121 246 Q NP_000836.2 503 QWAHREHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHS 581 (908) Q Consensus 503 ~w~~~~~~~p~s~Cs~~c~~G~~k~~~~~-~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s~ 581 (908) .|.+ +...|.+.|+++|++|+++...++ +.|||.|.+|+.++++++..+|..||.+.||+++++.|...+..+..++. T Consensus 505 ~w~~-~~~~p~s~c~~~C~~G~~~~~~~~~~~cc~~c~~C~~~~~~~~~~~c~~c~~~~~~~~~~~~c~~~~~~~~~~~~ 583 (877) T 6N4X_A 505 VWSK-KSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGD 583 (877) T ss_dssp HSSS-SSSSCCCCSSCCCCSSSCCCCCCSSCSSCCCCCCCCSSSCCCSSSCC---------------------------- T ss_pred cccc-CCCcceeecCCCCCCCeeEeeeCCcceeceeEecCCCCeEeCCCcccccCCCCeeeCCCCCCCeeccceeccCCC Confidence 7865 346689999999999998877666 68999999999999998889999999999999999999887788888999 Q NP_000836.2 582 PWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCF 661 (908) Q Consensus 582 ~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~~~~C~~~~~~~~~gf~l 661 (908) ++.+++.++++++++++++++++++++|+++.+|++++.|+.++|+|++++|++++++++.|+...|.+|.|++++||++ T Consensus 584 ~~~i~~~~~~~~~i~~~~~~~~~~~~~r~~~~ik~~~~~~~~~~l~g~~l~~~~~~~~~~~~~~~~C~~~~~~~~l~f~l 663 (877) T 6N4X_A 584 PEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAM 663 (877) T ss_dssp -------------------------------------------------------------------------------- T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHccCCchhhcCCHHHHHHHHHHHHHHHHHHHHHccCcchhhHHHHHhHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q NP_000836.2 662 SYAALLTKTNRIHRIFEQGKKSV--TAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGV 739 (908) Q Consensus 662 ~~~~l~~K~~ri~~if~~~~~~~--~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~~~~~~~~~~ 739 (908) +||+|++|+||++++|.+++.++ ++.++++++.+++++++++++++++++.|+.++|+........ ..... T Consensus 664 ~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~-------~~~~~ 736 (877) T 6N4X_A 664 SYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPS-------IREVY 736 (877) T ss_dssp -------------------------------------------------------------------------------- T ss_pred HHHHHHHHHHHHHHHHhcCCCCCCCCCCccCCHHHHHHHHHHHHHHHHHHHHHHHhcCCCCcccCCCc-------CceEE Confidence 99999999999999998765421 1123567777888888899999999999999999876543211 12345 Q NP_000836.2 740 LKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLT 819 (908) Q Consensus 740 ~~C~~~~~~~~~~~~~~~~ll~~~~~la~~~R~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 819 (908) ..|.+.+.+++++++|+++|++++++|||++|++|++|||+|+|++++|+++++|++++++++..... +.+.+ T Consensus 737 ~~C~~~~~~~~~~~~y~~~ll~~~~~la~~~R~~~~~~ne~~~i~~~~~~~~~~~~~~~~~~~~~~~~-------~~~~~ 809 (877) T 6N4X_A 737 LICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK-------IITMC 809 (877) T ss_dssp -------------------------------------------------------------------------------- T ss_pred EEccCCCHHhHHHHHHHHHHHHHHHHHHHHhcCCCccccHHHHHHHHHHHHHHHHHHHHHHHHcCCch-------HHHHH Confidence 78998766677899999999999999999999999999999999999999999999999998654322 23666 Q NP_000836.2 820 VSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRS 855 (908) Q Consensus 820 ~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~~ 855 (908) ++++++++++|+++|+||+|.++++|+++.+.+.+. T Consensus 810 ~~~~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~~ 845 (877) T 6N4X_A 810 FSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTT 845 (877) T ss_dssp ------------------------------------ T ss_pred HHHHHHHHHHHHHHHhhhhhHHHhCcccchhhhhee Confidence 788899999999999999999999999988765333 No 2 >6N52_B Metabotropic glutamate receptor 5; Cell Surface Receptor, MEMBRANE PROTEIN; HET: NAG; 4.0A {Homo sapiens} Probab=100.00 E-value=1.2e-76 Score=718.13 Aligned_cols=803 Identities=44% Similarity=0.810 Sum_probs=569.0 Template_Neff=10.400 Q NP_000836.2 34 QEYAHSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD 109 (908) Q Consensus 34 ~~~~~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~ 109 (908) ++.......+++++||+++|.++... ....|+......+.....|+++|++++|+++++++|+++++.+.|+++++ T Consensus 29 ~~~~~~~~~~~~i~Ig~l~p~~~~~~~~~~~~~~C~~~~~~~g~~~~~a~~~Av~~iN~~~~~l~~~~l~~~i~Dt~~~~ 108 (871) T 6N52_B 29 SERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHS 108 (871) T ss_dssp ---CCCEEECCSEEEEEEECCBCCCCGGGTTTTCCCSBCCCCCCHHHHHHHHHHHHHHSCTTSSTTCCEEEEEEECTTSH T ss_pred CCceEEEEeCCCEEEEEEEeeccCCCcccccccccccccccccHHHHHHHHHHHHHHhcCCCCCCCCeeccEEecCCCCH Confidence 34445578899999999999987521 13467654444567788999999999999888888999999999999886 Q NP_000836.2 110 TYALEQSLTFVQALIEK---DASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN 186 (908) Q Consensus 110 ~~a~~~~~~~~~~l~~~---~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~ 186 (908) ..+.+.+.+++.+.... ......|...++.+....+++++++|+.++..+.+++.++...++|++++.++++.++++ T Consensus 109 ~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~aviG~~~s~~~~~~a~~~~~~~ip~is~~~~s~~l~~~ 188 (871) T 6N52_B 109 AVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDK 188 (871) T ss_dssp HHHHHHHHHHHHHHHHHHHC-------------CCCCCCCEEEEECCSCHHHHHHHHHHHGGGTCCEEESSCCCGGGGCT T ss_pred HHHHHHHHHHHHhccCCCcccccceeccCCCcccccCCCCeEEEECCCCcHHHHHHHHHHHHhCCCEEeeccCCcccCCc Confidence 65555544443321000 000000000000000112478899999888877788889999999999998877777665 Q NP_000836.2 187 TRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKII 266 (908) Q Consensus 187 ~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~ 266 (908) ..+++++++.|++..+++++++++++++|+++++++++++++....+.+++.+++. ++++.....+..+.+..++...+ T Consensus 189 ~~~p~~~r~~p~~~~~~~al~~~l~~~~w~~v~ii~~~~~~g~~~~~~~~~~~~~~-gi~i~~~~~~~~~~~~~~~~~~~ 267 (871) T 6N52_B 189 TLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKE-GICIAHSYKIYSNAGEQSFDKLL 267 (871) T ss_dssp TTCTTEEESSCCSHHHHHHHHHHHHHHTCCEEEEEEESSHHHHHHHHHHHHHHTTT-TCEECCCCEECTTCCHHHHHHHH T ss_pred cccCcccCCCCCHHHHHHHHHHHHHHcCCcEEEEEEeCCcchHHHHHHHHHHHHHc-CcEEEEEEEEccCCChHHHHHHH Confidence 56899999999999999999999999999999999987778888888888888775 46654332222111223455666 Q NP_000836.2 267 KRLLE-TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 267 ~~l~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) +++++ ..+.+++++......+..+++++++.|+.+++.|++.+.|...............+.+.+.......+.|..++ T Consensus 268 ~~l~~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~f~~~~ 347 (871) T 6N52_B 268 KKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYY 347 (871) T ss_dssp HHHHTTTTTCCEEEEESCHHHHHHHHHHHHHHTCTTTCEEEECGGGSSCTTTTTTCTTTSTTCEEEEECCCCCHHHHHHH T ss_pred HHHHhcCCCceEEEEECChhhHHHHHHHHHHhCCCCcEEEEEecccccCccccCCchhhcccceeeeecCCCCCcHHHHH Confidence 66652 12667777766666778899999888876445677766554322110001112233333332222233333333 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKR-NSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLC 424 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~ 424 (908) ....+...+.+.++.++|++.+++........ ..+...|+..+.... ......++.++|||++++++|++++....+ T Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~yDAv~~~a~al~~~~~~~~ 425 (871) T 6N52_B 348 LKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKT--HHVQDSKMGFVINAIYSMAYGLHNMQMSLC 425 (871) T ss_dssp HTCCTTTCCSSTTHHHHHHHHSCEECTTSTTCCTTCCEECCTTCCSCT--TCCCCTTHHHHHHHHHHHHHHHHHHHHHHS T ss_pred HhcCcccCCCChHHHHHHHHHcCCCCCCCCcccccCcccCCCcccccc--ccccchhHHHHHHHHHHHHHHHHHHHhhcC Confidence 22211122334566777776655432110000 001122332221110 012234677899999999999999876443 Q NP_000836.2 425 PGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTP-VTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVED 501 (908) Q Consensus 425 ~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~-v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~~ 501 (908) ......|......++..+.+.+++.+|.|.+| + ++||++|++...+.+.+++..+ +...++.||.|+... .++ .. T Consensus 426 ~~~~~~c~~~~~~~~~~l~~~l~~~~f~G~tG-~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~~vg~~~~~~l~~~-~~ 503 (871) T 6N52_B 426 PGYAGLCDAMKPIDGRKLLESLMKTNFTGVSG-DTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD-DD 503 (871) T ss_dssp TTCSSCCGGGSSCCSHHHHHHHHTCEEECTTC-CEEECCTTCBCCCEEEEEEEECCSSSCCEEEEEEEEETTEEEEC-TT T ss_pred CCCCCCCcccCCCCHHHHHHHHhcCceecCCC-CEEEeCCCCCCCcceEEEEEEEeCCCeEEEEEEEEEeCCceEec-cc Confidence 22112232222234556778888889999988 6 9999999998889999887532 123578999998652 122 24 Q NP_000836.2 502 MQWAHREHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWH 580 (908) Q Consensus 502 i~w~~~~~~~p~s~Cs~~c~~G~~k~~~~~-~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s 580 (908) +.|.+ +...|.+.|+.+|++|+++...++ +.|||.|.+|+.++++++..+|..||.+.||+++++.|...+..+..++ T Consensus 504 ~~w~~-~~~~p~s~cs~~C~~G~~~~~~~~~~~cc~~c~~C~~~~~~~~~~~c~~c~~~~~~~~~~~~c~~~~~~~~~~~ 582 (871) T 6N52_B 504 EVWSK-KSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWG 582 (871) T ss_dssp TSSSS-SCCSCCCCSSCCCCTTTEECCBCSSCSSCBCCEECCTTEEECSSSCEEECCTTEECCTTSSSCEECCCCCCCSS T ss_pred hhccc-CCCCceeeecCCCCCCeeEeccCCCCeeccCcccCCCCeEeCCCcccccCCCCeecCCCCCCceecceeeccCC Confidence 67865 346689999999999999887767 6899999999999999988999999999999999999988777888889 Q NP_000836.2 581 SPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC 660 (908) Q Consensus 581 ~~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~~~~C~~~~~~~~~gf~ 660 (908) .++.+++.++++++++++++++++++++|+++++|++++.+++++|+|++++|++++++++.|+...|.+|.|++++||+ T Consensus 583 ~~~~i~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~~~~~~~~~~l~g~~~~~~~~~~~~~~~~~~~C~~~~~~~~~gf~ 662 (871) T 6N52_B 583 DPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPA 662 (871) T ss_dssp CHHHHHHHHHHHHHHHHHHHHTTTTTTTTTCHHHHSSCTTHHHHHHHHHHHHHHHHHHHSSCCCTTHHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHccCCCcccCCCHHHHHHHHHHHHHHHHHHHHHccCcchhHHHHHHhHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q NP_000836.2 661 FSYAALLTKTNRIHRIFEQGKKSV--TAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARG 738 (908) Q Consensus 661 l~~~~l~~K~~ri~~if~~~~~~~--~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~~~~~~~~~ 738 (908) ++||+|++|+||++++|++.+.++ +..++++.+.+++++++++++++++++.|+.++|+........ .... T Consensus 663 l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~i~~~~~~~~p~~~~~~~~~-------~~~~ 735 (871) T 6N52_B 663 MSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPS-------IREV 735 (871) T ss_dssp HHHHHHHHHHHTCC--------------------CCHHHHHHHHHHHHHHHHHHHHHHSCCCEECCCSS-------SSCC T ss_pred HHHHHHHHHHHHHHHHHHcCCCCCCCCCCccCCHHHHHHHHHHHHHHHHHHHHHHHhcCCCCcccCCCC-------CceE Confidence 999999999999999998765421 1123566777888888899999999999999999876533211 1234 Q NP_000836.2 739 VLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTL 818 (908) Q Consensus 739 ~~~C~~~~~~~~~~~~~~~~ll~~~~~la~~~R~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 818 (908) ...|.+.+.+++++++|.++|++++++|||++|++|++|||+|+|++++|+++++|++++++++..... +.+. T Consensus 736 ~~~C~~~~~~~~~~~~~~~~ll~~~~~la~~~R~~~~~~nE~k~i~~~~~~~~~~~~~~~~~~~~~~~~-------~~~~ 808 (871) T 6N52_B 736 YLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK-------IITM 808 (871) T ss_dssp CCEECCCHHHHHHHHHHHHHHHHHHHHHHHHSTTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCT-------THHH T ss_pred EEEccCCcHHhHHHHHHHHHHHHHHHHHHHHhcCCCccccHHHHHHHHHHHHHHHHHHHHHHHhCCCch-------HHHH Confidence 678998766677899999999999999999999999999999999999999999999999998755322 2366 Q NP_000836.2 819 TVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSF 856 (908) Q Consensus 819 ~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~~~ 856 (908) ++.++++++++|+++|+||+|.++++|+++.+++.+.+ T Consensus 809 ~~~~~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~~~ 846 (871) T 6N52_B 809 CFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTS 846 (871) T ss_dssp HHHHHHHHHHHHHTTTTTTSCCCCCSGGGC-------- T ss_pred HHHHHHHHHHHHHHHHhhhhhhhhhCcccchhhhheec Confidence 67888999999999999999999999998887664443 No 3 >6N51_B Metabotropic glutamate receptor 5, Nanobody; Cell Surface Receptor, MEMBRANE PROTEIN; HET: NAG, QUS; 4.0A {Homo sapiens} Probab=100.00 E-value=6.7e-76 Score=706.52 Aligned_cols=786 Identities=44% Similarity=0.821 Sum_probs=571.7 Template_Neff=10.700 Q NP_000836.2 37 AHSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYA 112 (908) Q Consensus 37 ~~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a 112 (908) ......+++++||+++|.|+... ....|+......+.+...|+++|++++|+++++++|+++++++.|+++++..+ T Consensus 4 ~~~~~~~~~i~Ig~l~p~~~~~~~~~~~~~~c~~~~~~~g~~~~~a~~~Av~~iN~~~~~l~~~~l~~~~~Dt~~~~~~a 83 (804) T 6N51_B 4 RVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVA 83 (804) T ss_pred cceeEecCCEEEEeEeeccCCCCCCCCCCCCcccccCcccHHHHHHHHHHHHHHHcCCCCCCCCeeeEEEEeCCCCHHHH Confidence 34467788999999999987532 13467754445667789999999999999888888999999999998876555 Q NP_000836.2 113 LEQSLTFVQALIEK---DASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRY 189 (908) Q Consensus 113 ~~~~~~~~~~l~~~---~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~ 189 (908) .+.+.+++.+.... ......+...++.+...++++++++|+.++..+..++.+++..++|++++.+.++.++++..+ T Consensus 84 ~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~aviG~~~s~~~~~~a~~~~~~~ip~is~~~~~~~l~~~~~~ 163 (804) T 6N51_B 84 LEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLF 163 (804) T ss_pred HHHHHHHHccCCCCCcccCCceecCCCCccccccCCCceEEEcCCChHHHHHHHHHHHHhCCCccccccCCcccCCcccC Confidence 44444443210000 000000000000000112578899999888877788889999999999998877776655568 Q NP_000836.2 190 DFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRL 269 (908) Q Consensus 190 ~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l 269 (908) ++++++.|++..++.++++++++++|+++++++++++++....+.+++.+++. ++++.....+..+.+..++.+.++++ T Consensus 164 ~~~~r~~ps~~~~~~al~~~l~~~~w~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~i~~~~~~~~~~~~~~~~~~~~~l 242 (804) T 6N51_B 164 KYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKE-GICIAHSYKIYSNAGEQSFDKLLKKL 242 (804) T ss_pred CcccccCCCHHHHHHHHHHHHHHhCCcEEEEEEecChhhHHHHHHHHHHHHHc-CcEEEEEEEeCCCCCccchHHHHHHH Confidence 99999999999999999999988999999999988788888888888888775 46654332222111223455666666 Q NP_000836.2 270 LE-TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSR 348 (908) Q Consensus 270 ~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~ 348 (908) ++ ..+.+++++......+..+++++++.|+.+++.|++.+.|...............+.+.+.........|..++... T Consensus 243 ~~~~~~~~vvv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~f~~~~~~~ 322 (804) T 6N51_B 243 TSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKL 322 (804) T ss_pred HhcCCCcEEEEEECCHHHHHHHHHHHHHhCCCCCeEEEEeccccCCCCccccchhhhceEEEEeccCCCCCCHHHHHHhC Confidence 53 12567777666666778899999988876445677665544321110001112223333322222222333332221 Q NP_000836.2 349 TLANNRRNVWFAEFWEENFGCKLGSHGKR-NSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGY 427 (908) Q Consensus 349 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~ 427 (908) .+.....+.++.++|++.+++........ ..+...|+..+.... ......++.++|||++++++|++++..+.+... T Consensus 323 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~yDAv~~~a~al~~~~~~~~~~~ 400 (804) T 6N51_B 323 RPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKT--HHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGY 400 (804) T ss_pred CCCCCCCChHHHHHHHHHcCCCCCCCCCCCCcCCccCCCCccccc--CCCcchhHHHHHHHHHHHHHHHHHHHhccCCCC Confidence 11112234566677766655432110000 001123332221110 012334677899999999999999876443221 Q NP_000836.2 428 IGLCPRMSTIDGKELLGYIRAVNFNGSAGTP-VTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVEDMQW 504 (908) Q Consensus 428 ~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~-v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~~i~w 504 (908) ...|......++..+.+.+++.+|.|.+| . +.||++|++...+.+.+++..+ +...++.||.|+... .++ ..+.| T Consensus 401 ~~~c~~~~~~~~~~l~~~l~~~~f~G~tG-~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~~vg~~~~~~l~~~-~~~~w 478 (804) T 6N51_B 401 AGLCDAMKPIDGRKLLESLMKTNFTGVSG-DTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD-DDEVW 478 (804) T ss_pred CCCCcccCCCCHHHHHHHHhheeeecCCC-CEEEECCCCCcCCeeEEEEEEECCCCcEEEEEEEEEcCCceEEe-ceeec Confidence 12222212234556778888889999988 6 9999999998889999988532 223578999998652 222 24678 Q NP_000836.2 505 AHREHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPW 583 (908) Q Consensus 505 ~~~~~~~p~s~Cs~~c~~G~~k~~~~~-~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s~~~ 583 (908) ..+ ...|.+.|+.+|++|+++...++ +.|||.|.+|+.++++++..+|..||.+++|+++++.|...+..+..+++++ T Consensus 479 ~~~-~~~p~s~cs~~C~~g~~~~~~~~~~~cc~~c~~C~~~~~~~~~~~c~~c~~~~~~~~~~t~c~~~~~~~~~~~~~~ 557 (804) T 6N51_B 479 SKK-SNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPE 557 (804) T ss_pred CCC-CCCCCccccCCCCCCceecCCCCCCccceeeeeCCCCcccCCCcceecCCCCCcCCCCCCceeeccchhcCCCcHH Confidence 652 46689999999999998877666 7899999999999999888999999999999999999988888888999999 Q NP_000836.2 584 AVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSY 663 (908) Q Consensus 584 ~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~~~~C~~~~~~~~~gf~l~~ 663 (908) .+++.++++++++++++++++++++|+++.+|++++.+++++|+|++++|++++++++.|+...|.+|.|++++||+++| T Consensus 558 ~i~~~~~~~~~i~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~l~g~~~~~~~~~~~~~~~~~~~C~~~~~~~~~~~~l~~ 637 (804) T 6N51_B 558 PIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSY 637 (804) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHCCCCcccccCCHHHHHHHHHHHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q NP_000836.2 664 AALLTKTNRIHRIFEQGKKSV--TAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLK 741 (908) Q Consensus 664 ~~l~~K~~ri~~if~~~~~~~--~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~~~~~~~~~~~~ 741 (908) |+|++|+||++++|++++.++ +..++++.+.+++++++++++|+++++.|+.++|+........ ....+.. T Consensus 638 ~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~-------~~~~~~~ 710 (804) T 6N51_B 638 SALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPS-------IREVYLI 710 (804) T ss_pred HHHHHHHHHHHHHHhcCCCCCCCCccccCCHHHHHHHHHHHHHHHHHHHHHHHHhCCCCCCCCCCC-------CCcEEEE Confidence 999999999999998765321 1123456677777888889999999999999999876543211 1234668 Q NP_000836.2 742 CDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVS 821 (908) Q Consensus 742 C~~~~~~~~~~~~~~~~ll~~~~~la~~~R~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 821 (908) |...+.+++++++|.++|++++++|||++|++|++|||+|+|++++|+++++|++++++++..... +.+.+++ T Consensus 711 C~~~~~~~~~~~~~~~~ll~~~~~la~~~r~~~~~~~e~~~i~~~~~~~~~~~~~~~~~~~~~~~~-------~~~~~~~ 783 (804) T 6N51_B 711 CNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK-------IITMCFS 783 (804) T ss_pred cCCCcHHHHHHHHHHHHHHHHHHHHHHHhCCCCccccHHHHHHHHHHHHHHHHHHHHHHHhCCCch-------HHHHHHH Confidence 998766677899999999999999999999999999999999999999999999999998765322 2366788 Q NP_000836.2 822 MSLSASVSLGMLYMPKVYIII 842 (908) Q Consensus 822 i~~~~~~~l~~~f~PK~~~i~ 842 (908) ++++++++|+++|+||+|.|+ T Consensus 784 ~~~~~~~~l~~~f~Pk~~~i~ 804 (804) T 6N51_B 784 VSLSATVALGCMFVPKVYIIL 804 (804) T ss_pred HHHHHHHHHHHHHHhhhhhcC Confidence 899999999999999999874 No 4 >6W2Y_A Gamma-aminobutyric acid type B receptor; Inhibitor, Homodimer, GPCR, SIGNALING PROTEIN; HET: SGG, L9Q, NAG; 3.2A {Homo sapiens} Probab=100.00 E-value=3.8e-66 Score=620.75 Aligned_cols=685 Identities=21% Similarity=0.299 Sum_probs=472.4 Template_Neff=10.100 Q NP_000836.2 36 YAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQ 115 (908) Q Consensus 36 ~~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~ 115 (908) .......+++++||+++|.++.. ..+.....|+++|++++|+++++++|+++++.+.|+++++..+.+. T Consensus 22 ~~~~~~~~~~i~IG~l~p~~~~~-----------~~g~~~~~a~~~Av~~iN~~~~il~g~~l~l~~~Dt~~~~~~a~~~ 90 (829) T 6W2Y_A 22 PPHPSSERRAVYIGALFPMSGGW-----------PGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKY 90 (829) T ss_dssp ------CCEEEEEEEEECSSSSC-----------CCSTTTHHHHHHHHHHHHHCTTTSTTEEEEEEEEECTTCHHHHHHH T ss_pred CCCCCCCCceEEEEEEEecCCCC-----------CCcchHHHHHHHHHHHHHhCCCCCCCcEEEEEEecCCCCHHHHHHH Confidence 34455677899999999998642 1356778999999999999888888999999999998876544433 Q NP_000836.2 116 SLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRV 195 (908) Q Consensus 116 ~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~ 195 (908) +.+++. .+++++++|+.++..+..++.+++.+++|+|+++++++.++++..+++++|+ T Consensus 91 ~~~l~~----------------------~~~v~~viG~~~s~~~~~va~~~~~~~ip~is~~a~s~~ls~~~~~p~~frt 148 (829) T 6W2Y_A 91 LYELLY----------------------NDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRT 148 (829) T ss_dssp HHHTTS----------------------SSSCEEEEEECSHHHHHHHHHTTTTTTCEEEESSCCCGGGGCTTTCTTEEES T ss_pred HHHHHh----------------------cCCcEEEEECCChHHHHHHHHHHHHcCCEEEecccCChhHhccccCCceEEc Confidence 333322 1478899999888888888899999999999999888887776678999999 Q NP_000836.2 196 VPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNA 275 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 275 (908) .|++..++.++++++++++|++|++++++++++....+.+++.+++. ++++.....+. .+....++++++ .++ T Consensus 149 ~ps~~~~~~a~~~ll~~~~w~~vaii~~~~~~~~~~~~~~~~~~~~~-gi~v~~~~~~~-----~d~~~~~~~l~~-~~~ 221 (829) T 6W2Y_A 149 HPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEA-GIEITFRQSFF-----SDPAVPVKNLKR-QDA 221 (829) T ss_dssp SCCSGGGHHHHHHHHHHHCCCEEEEEECCSTTHHHHHHHHHHHHHTT-TCEEEEEEECS-----SCCHHHHHHHHH-TTC T ss_pred CCChhhccHHHHHHHHHhCCeEEEEEEeCCcccchhHHHHHHHHHHc-CCEEEEEEccc-----CCchHHHHHHhh-CCC Confidence 99999999999999999999999999988888888888888888775 47765443332 134455667763 578 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSD----SWGSKIAPV-----YQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~----~~~~~~~~~-----~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) ++|++......+..+++++++.|+.+ ++.|+..+ .|....... .......+|.+....... T Consensus 222 riIv~~~~~~~~~~~l~~a~~~g~~~~~~vwi~~~~~~~~w~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~--------- 292 (829) T 6W2Y_A 222 RIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVML--------- 292 (829) T ss_dssp SEEEEECCHHHHHHHHHHHTTTTCCSTTCEEEEESCSCSSCTTSCCTTCCSCHHHHHTTTTTCEEEEECCS--------- T ss_pred EEEEEeCCHHHHHHHHHHHHHccccCCCeEEEEeccccccchhccCCCCCCCHHHHHHHHcccEEEEEecc--------- Confidence 99988877777888999998888764 56777653 222110000 001112233322211000 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) ... ......+.++.++++++..+ .... + . ......++..+|||++++++|++++....+. T Consensus 293 ~~~-~~~~~~~~~~~~f~~~~~~~-~~~~---~----~-----------~~~~~~~a~~~YDAv~~~a~Al~~~~~~~~~ 352 (829) T 6W2Y_A 293 NPA-NTRSISNMTSQEFVEKLTKR-LKRH---P----E-----------ETGGFQEAPLAYDAIWALALALNKTSGGGGR 352 (829) T ss_dssp CCS-CCCCTTSCCHHHHHHHHHTT-CSSC---T----T-----------TSTTSSSHHHHHHHHHHHHHHHHHHC----- T ss_pred CCC-CCCCcCCCCHHHHHHHHHHH-HhcC---C----c-----------cCCCCccccHHHHHHHHHHHHHHHHhhcCcc Confidence 000 00000122233333322111 1000 0 0 0112345778999999999999998754321 Q NP_000836.2 426 GYIGLCPR----MSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVED 501 (908) Q Consensus 426 ~~~~~~~~----~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~ 501 (908) . +.+.. .....++.+.++|++.+|.|.+| ++.||++|++...+.+.+++ ++.++.||.|+.... . T Consensus 353 ~--~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~tG-~v~fd~~G~r~~~~~i~~~~----~~~~~~vg~~~~~~~----~ 421 (829) T 6W2Y_A 353 S--GVRLEDFNYNNQTITDQIYRAMNSSSFEGVSG-HVVFDASGSRMAWTLIEQLQ----GGSYKKIGYYDSTKD----D 421 (829) T ss_dssp -----CCTTCCTTCTTHHHHHHHHHHTCEEEETTE-EEEBCTTSCBCCEEEEEEES----SSSEEEEEEEETTTC----C T ss_pred C--CCCHHHcCCCChHHHHHHHHHHHcCcccccee-eEEeCCCCCccceEEEEEee----CCeEEEEEEEECCCC----C Confidence 1 10100 01123446778888889999988 89999999998888888887 357899999986531 2 Q NP_000836.2 502 MQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHS 581 (908) Q Consensus 502 i~w~~~~~~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s~ 581 (908) +.|... ..|+.|. +|.| ++.| ...+..++. T Consensus 422 l~~~~~----------~~w~~g~-------------------------------~p~d------~~~~---~~~~~~~s~ 451 (829) T 6W2Y_A 422 LSWSKT----------DKWIGGS-------------------------------PPAD------QTLV---IKTFRFLSQ 451 (829) T ss_dssp CBCCSC----------CCCSSSS-------------------------------CCCS------SCCE---EEEECCCCS T ss_pred ceecCC----------CccCCCC-------------------------------CCCC------Ccee---ceeecccCH Confidence 344221 1222221 2434 4444 334455667 Q NP_000836.2 582 PWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFL------MIAAP-DTIICSFRRVF 654 (908) Q Consensus 582 ~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~------~~~~~-~~~~C~~~~~~ 654 (908) ++.+++.++++++++++++++++++++|+++.+|+++|.+++++|+|++++|+++++ ++..+ +...|.+|.|+ T Consensus 452 ~~~i~~~~~~~~gi~~~~~~~~~~~~~r~~~~ik~s~~~l~~~~l~G~~l~~~~~~~~~~~~~~i~~~~~~~~C~~~~~~ 531 (829) T 6W2Y_A 452 KLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWL 531 (829) T ss_dssp SHHHHHHHHHHHHHHHHHHHHHHHHSCSSSHHHHHSCHHHHHHHHHHHHHHHHTTTTTTCSSSSCCTTTHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHcccChhhhCCCHHHHHHHHHHHHHHHHHHHHhcCCccCCCcccccHHHHHHHHH Confidence 788888999999999999999999999999999999999999999999999999986 34444 68999999999 Q NP_000836.2 655 LGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRT---- 730 (908) Q Consensus 655 ~~~gf~l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~---- 730 (908) +++||+++||+|++|+||++++|++++.++.+++.++++.++.++++++++|++++++|++++|+..........+ T Consensus 532 ~~~gf~l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~l~~~~~~l~~i~~iil~~w~~~~p~~~~~~~~~~~~~~~~ 611 (829) T 6W2Y_A 532 LGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKED 611 (829) T ss_dssp HHHHHHHHHHHHHHHHHHHHHTC---------------CCHHHHHHHHHHHHHHHHHHHHHHSCCCEEEEECCCCCC--- T ss_pred HHHHHHHHHHHhhhhceEEEEEeecccccchhhccCCHHHHHHHHHHHHHHHHHHHHHHHHHCcccceeeecccCCCCcc Confidence 9999999999999999999999997765322245678899999999999999999999999999986543211000 Q NP_000836.2 731 LDPEKARGVLKCDISD--LSLICSLGYSILLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQS 807 (908) Q Consensus 731 ~~~~~~~~~~~C~~~~--~~~~~~~~~~~~ll~~~~~la~~~R~~~-~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~ 807 (908) .+....+..+.|.+.+ .|++++++|+++|+++|++|||++|+++ ++|||+|+|++++|+++++|+++++++++.... T Consensus 612 ~~~~~~~~~~~C~~~~~~~~~~~~~~y~~lll~~~~~la~~tR~~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~ 691 (829) T 6W2Y_A 612 IDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQ 691 (829) T ss_dssp -CCEEEEEEEEECCSSHHHHHHHHHHHHHHHHHHHHHHHHHTCC------CCCSTHHHHHHHHHHHHHHHHHHHHHGGGC T ss_pred CCceeeceEEeecCCCcHHHHHHHHHHHHHHHHHHHHHHHHhcCCCchhhccHHHHHHHHHHHHHHHHHHHHHHHHhcCc Confidence 0000123367999864 7888999999999999999999999999 899999999999999999999999998766543 Q NP_000836.2 808 AEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRK 853 (908) Q Consensus 808 ~~~~~~~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~ 853 (908) + ...+.+.+++++++++++|+++|+||+|.++++++.+.+... T Consensus 692 ~---~~~~~~~~~~i~~~~~~~l~~~f~PK~~~~~~~~~~~~~~~~ 734 (829) T 6W2Y_A 692 Q---DAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQD 734 (829) T ss_dssp T---TTHHHHHHHHHHHHHHHHHHHHTHHHHHHHC----------- T ss_pred h---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccccchhhhh Confidence 2 355678889999999999999999999999998887765543 No 5 >6W2X_B Gamma-aminobutyric acid type B receptor; Inhibitor, Heterodimer, GPCR, SIGNALING PROTEIN; HET: SGG, L9Q, NAG; 3.6A {Homo sapiens} Probab=100.00 E-value=8.6e-65 Score=611.36 Aligned_cols=678 Identities=20% Similarity=0.302 Sum_probs=482.9 Template_Neff=9.500 Q NP_000836.2 36 YAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQ 115 (908) Q Consensus 36 ~~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~ 115 (908) ........++++||+++|.++.... ...+.....|+++|++++|+++ .++|+++++.+.|+++++..+.+. T Consensus 13 ~~~~~~~~~~i~IG~l~p~s~~~~~--------~~~g~~~~~a~~~Av~~IN~~~-~l~~~~l~l~~~Dt~~~~~~a~~~ 83 (908) T 6W2X_B 13 APRPPPSSPPLSIMGLMPLTKEVAK--------GSIGRGVLPAVELAIEQIRNES-LLRPYFLDLRLYDTECDNAKGLKA 83 (908) T ss_dssp -------CCEEEEEEECCCCSSSTT--------THHHHSSHHHHHHHHHHHHHHT-CSSSCEEEEEEECCTTCHHHHHHH T ss_pred CCCCCCCCCCEEEEEEEeCCccccC--------CcccccHHHHHHHHHHHHHhcC-CCCCeEEEEEEecCCCChHHHHHH Confidence 3445567889999999999874310 0246678899999999999875 466899999999998876544443 Q NP_000836.2 116 SLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRV 195 (908) Q Consensus 116 ~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~ 195 (908) +.+++. . .+++++++|+.++..+.+++.+++.+++|+|+++++++.++++..+++++|+ T Consensus 84 ~~~ll~----~-----------------~~~v~aviG~~~S~~~~~va~~~~~~~ip~Is~~ats~~Ls~~~~yp~ffrt 142 (908) T 6W2X_B 84 FYDAIK----Y-----------------GPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRT 142 (908) T ss_dssp HHHHHH----T-----------------SCCCCCEEECCSHHHHHHHTTSCTTTTCCEEESSCCCSGGGCTTTCSSEEES T ss_pred HHHHHH----h-----------------CCCeEEEEecCCHHHHHHHHHHhcccCCEEEEcccCChhHcCcccCCceeec Confidence 333332 1 1368899999988888888999999999999999988888776678999999 Q NP_000836.2 196 VPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNA 275 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 275 (908) .|++..+++++++++++++|++|++++++++++....+.+++.+++. ++++.....+. .+....++++++ .++ T Consensus 143 ~ps~~~~~~al~~ll~~~~W~~Vaii~~d~~~g~~~~~~~~~~~~~~-gi~i~~~~~~~-----~d~~~~l~~lk~-~~a 215 (908) T 6W2X_B 143 VPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGE-DIEISDTESFS-----NDPCTSVKKLKG-NDV 215 (908) T ss_dssp SCCTTSSHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHTTTS-SCEEEEEEEES-----SCCHHHHHHHHH-HTC T ss_pred CCCHHhhcHHHHHHHHHcCCcEEEEEEeccHHHHHHHHHHHHHHhcC-CCEEeeEeeec-----CChhHHHHHHhc-CCc Confidence 99999999999999999999999999988888888888888877775 46765443332 234556677763 578 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVY-------------QQEEIAEGAVTILPKRASIDGF 341 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~-------------~~~~~~~g~~~~~~~~~~~~~~ 341 (908) ++|++......+..+++++.+.|+.+ ++.|+..+ |........ ......+|.+.+.........+ T Consensus 216 riIv~~~~~~~~~~~l~~a~~~g~~~~~~vwI~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~i~~~~~~~~~~~~ 294 (908) T 6W2X_B 216 RIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPG-WYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQI 294 (908) T ss_dssp CEEECCCCHHHHHHHHHHHHHHTCCSTTCEEECCC-CCCTTTTC------------CHHHHHHHSSEEEEEECSSCCCCC T ss_pred EEEEEeCCHHHHHHHHHHHHHcCCCCCCeEEEeec-CCCcchHHhccccccCCcchHHHHHHHHCCceEEEecCCCcCcc Confidence 99888877777888999998888764 57788764 322110000 0111223333222111000000 Q NP_000836.2 342 DRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHK 421 (908) Q Consensus 342 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~ 421 (908) ..+ ......++. +.+.+... ...+..++.++|||++++|+|++++.. T Consensus 295 ~~~----------~~~~~~~~~-~~~~~~~~----------------------~~~~~~~~~~aYDAv~~lA~Al~~~~~ 341 (908) T 6W2X_B 295 KTI----------SGKTPQQYE-REYNNKRS----------------------GVGPSKFHGYAYDGIWVIAKTLQRAME 341 (908) T ss_dssp CCT----------TSCCHHHHH-HHHHHHCS----------------------SSCCCTTHHHHHHHHHHHHHHHHHHHH T ss_pred ccc----------CCCCHHHHH-HHHHhhcC----------------------CCCCccchHHHHHHHHHHHHHHHHHHH Confidence 000 000011111 11211100 012345678899999999999999876 Q NP_000836.2 422 DLCPGY----IGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLH- 496 (908) Q Consensus 422 ~~~~~~----~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~- 496 (908) ..+... ...+.......+..+.++|++.+|.|.+| ++.|| +|++...+.+.+++ ++.++.||.|+.... T Consensus 342 ~~~~~~~~~~l~~~~~~~~~~g~~l~~~l~~~~F~G~tG-~v~Fd-~Gdr~~~~~I~~~~----~~~~~~VG~~~~~~~~ 415 (908) T 6W2X_B 342 TLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTG-QVVFR-NGERMGTIKFTQFQ----DSREVKVGEYNAVADT 415 (908) T ss_dssp HHHTC-----CCSCCTTCHHHHHHHHHHHTSCCCEETTE-ECCBS-SSSBCCEEEEEEEC----SSSEEEEEEEETTTTE T ss_pred HHHhcCCCCcHHhcCCCChHHHHHHHHHHHcCceecCce-eEEEe-CCceeceEEEEEEe----CCeEEEEEEEECCCCe Confidence 432110 00010111224556778888889999988 89999 89998889999988 257899999986421 Q NP_000836.2 497 --LKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPI 574 (908) Q Consensus 497 --~~~~~i~w~~~~~~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~ 574 (908) +....+.|.+ |. +|.+ ++.| .. T Consensus 416 l~~~~~~i~w~g----------------~~-------------------------------~P~d------~~~~---~~ 439 (908) T 6W2X_B 416 LEIINDTIRFQG----------------SE-------------------------------PPKD------KTII---LE 439 (908) T ss_dssp EECCTTTCCCSS----------------SS-------------------------------CCCS------SCCE---EC T ss_pred EEEEccccccCC----------------CC-------------------------------CCCC------ccch---hh Confidence 1111223321 10 2333 3333 23 Q NP_000836.2 575 IKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPD-------TII 647 (908) Q Consensus 575 ~~~~~s~~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~-------~~~ 647 (908) ....++.++.+++.++++++++++++++++++++|+++.+|++++.+++++|+|++++|++++++++.++ ... T Consensus 440 ~~~~~~~~~~~~~~~~~~~gi~~~~~~l~~~~~~r~~~~ik~s~~~l~~~il~G~~l~~~~~~~~~~~~~~~~~~~~~~~ 519 (908) T 6W2X_B 440 QLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETL 519 (908) T ss_dssp CCCCCCSSSHHHHHHHHHHHHHHHHHHHHHHHHTTTSHHHHHSCSSHHHHHHHHHHHHHHHHHHHHCCSSSSCHHHHHHH T ss_pred HHhcCCHHHHHHHHHHHHHHHHHHHHHHHHHHHhhcchhHHhCCHHHHHHHHHHHHHHHHHHHHHhcCCCCCChhHHHHH Confidence 3336677788888899999999999888899999999999999999999999999999999999888776 789 Q NP_000836.2 648 CSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGE 727 (908) Q Consensus 648 C~~~~~~~~~gf~l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~ 727 (908) |.+|.|++++||+++||+|++|+||++++|++++.+ ++.++++.++.+++++++++++++++|++++|+........ T Consensus 520 C~~~~w~~~lgf~l~~g~l~~K~~Ri~~if~~~~~~---~~~~~~~~l~~~~~~~~~i~~~il~~w~~~~p~~~~~~~~~ 596 (908) T 6W2X_B 520 CTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMK---KKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYS 596 (908) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC----------CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC T ss_pred HHHHHHHHHHHHHHHHHHHHHhHHHHHHHHcCcccc---ccccCHHHHHHHHHHHHHHHHHHHHHHHHhCccchhhhccc Confidence 999999999999999999999999999999876543 34678889999999999999999999999999876532110 Q NP_000836.2 728 QRT----LDPEKARGVLKCDIS--DLSLICSLGYSILLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIIWLAFIPI 800 (908) Q Consensus 728 ~~~----~~~~~~~~~~~C~~~--~~~~~~~~~~~~~ll~~~~~la~~~R~~~-~~~nes~~i~~~~~~~~~~~~~~~~~ 800 (908) ... .+.........|.+. ..|++++++|+++|+++|++|||++|++| ++|||+|+|++++|+++++|++++++ T Consensus 597 ~~~~~~~~~~~~~~~~~~C~~~~~~~~~~~~~~y~~llll~~~~la~~tR~v~~~~~nEsk~i~~a~~~~~~~~~~~~~~ 676 (908) T 6W2X_B 597 MEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAV 676 (908) T ss_dssp CBCC-----CEECCEEEEEECSSCHHHHHHHHHHHHHHHHHHHHHHHHTSSCCCSSCCCHHHHHHHHHHHHHHHHHHHHH T ss_pred CCCCCCCCCceeeceEEeecCCccHHHHHHHHHHHHHHHHHHHHHHHHhcCCCchhhccHHHHHHHHHHHHHHHHHHHHH Confidence 000 000012445789885 37888999999999999999999999999 99999999999999999999999999 Q NP_000836.2 801 FFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKR 852 (908) Q Consensus 801 ~~~~~~~~~~~~~~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~ 852 (908) +++....+ .+.+++.+++++++++++|+++|+||+|.++++|+++.... T Consensus 677 ~~~~~~~~---~~~~~~~~~~i~~~~~~~l~~if~PK~~~i~~~~~~~~~~~ 725 (908) T 6W2X_B 677 SFLTRDQP---NVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNR 725 (908) T ss_dssp HHHCSSSH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC-------- T ss_pred HHHhcCCh---hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCcchhcccc Confidence 88765432 35667888999999999999999999999999988765543 No 6 >6UO8_A Gamma-aminobutyric acid type B receptor; G protein-coupled receptor, GABA, GABAB; HET: BMA, QDA, NAG;{Homo sapiens} Probab=100.00 E-value=9.3e-65 Score=605.48 Aligned_cols=682 Identities=21% Similarity=0.300 Sum_probs=482.9 Template_Neff=10.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .+++++||+++|.+++. ..+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+.+++. T Consensus 3 ~~~~i~Ig~l~p~s~~~-----------~~~~~~~~a~~~Av~~iN~~~~il~g~~l~~~~~D~~~~~~~a~~~~~~l~~ 71 (762) T 6UO8_A 3 ERRAVYIGALFPMSGGW-----------PGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLY 71 (762) T ss_dssp CCEEEEEEEEECCSSSC-----------CCHHHHHHHHHHHHHHHTTCTTTCSSEEEEEEEEECTTCHHHHHHHHHHHHT T ss_pred CceeEEEEEEEecCCCC-----------CCcccHHHHHHHHHHHHHcCCCCCCCcEEEEEEccCCCCHHHHHHHHHHHHh Confidence 45789999999998753 1356678999999999999888888999999999998875544333333322 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++++++++|+.++..+..++.+++.+++|++++.++++.++++..+|+++|+.|++.. T Consensus 72 ----------------------~~~v~~viG~~~s~~~~~va~~~~~~~ip~is~~a~s~~ls~~~~~p~~fr~~ps~~~ 129 (762) T 6UO8_A 72 ----------------------NDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATL 129 (762) T ss_dssp ----------------------SSSCEEEEECCSHHHHHHHHHHGGGTTCEEEESSCCCGGGGCTTTCTTEEECSCCGGG T ss_pred ----------------------cCCcEEEEECCCHHHHHHHHHHHHHcCCEEEecccCChhhhccccCCceeecCCChhh Confidence 1478899999888888888889999999999999888877766678999999999999 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) +++++++++++++|++|++++++++++....+.+++.+++. ++++.....+. .+....++++++ .++|+|++. T Consensus 130 ~~~a~~~~l~~~~w~~vaii~~~~~~~~~~~~~~~~~~~~~-gi~v~~~~~~~-----~~~~~~l~~l~~-~~~~vIv~~ 202 (762) T 6UO8_A 130 HNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEA-GIEITFRQSFF-----SDPAVPVKNLKR-QDARIIVGL 202 (762) T ss_dssp SHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHTGGG-SCEEEECCEES-----SCCHHHHHHHHH-HTCSEEEEE T ss_pred ccHHHHHHHHHhCCcEEEEEEeCCccchhHHHHHHHHHHHc-CcEEEEEeccc-----CCchHHHHHHHh-CCCEEEEEe Confidence 99999999999999999999988888888888888887775 46665443332 134445666763 578988888 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSD----SWGSKIAP-----VYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLA 351 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~----~~~~~~~~-----~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~ 351 (908) .....+..+++++++.|+.+ ++.|+..+ .|...... ........+|.+...... .... .. T Consensus 203 ~~~~~~~~~l~~a~~~g~~~~~~v~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~---------~~~~-~~ 272 (762) T 6UO8_A 203 FYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVM---------LNPA-NT 272 (762) T ss_dssp CCSHHHHHHHHHHGGGTCCSSSCEEEEESCSCTTTTSSCCTTCCCCTHHHHTTSCSEEEEEECC---------SCCS-CC T ss_pred CCHHHHHHHHHHHHHcCcCCCCeEEEEEcccccchhhhcCCCCCCCHHHHHHHHCCcEEEEeec---------cCCC-CC Confidence 77777888999998888754 56777653 22211000 000111222322211100 0000 00 Q NP_000836.2 352 NNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLC 431 (908) Q Consensus 352 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~ 431 (908) ....+.++.++++++... .... + . ......++..+|||++++++|+++.....+.. +.+ T Consensus 273 ~~~~~~~~~~f~~~~~~~-~~~~---~----~-----------~~~~~~~~~~~yDav~~~a~al~~~~~~~~~~--~~~ 331 (762) T 6UO8_A 273 RSISNMTSQEFVEKLTKR-LKRH---P----E-----------ETGGFQEAPLAYDAIWALALALNKTSGGGGRS--GVR 331 (762) T ss_dssp CCTTSCCTTHHHHHHHHH-CSSC---T----T-----------TSTTCTTHHHHHHHHHHHHHHHHHHC----------C T ss_pred cCcCCCCHHHHHHHHHHH-HhcC---C----c-----------cCCCCccccHHHHHHHHHHHHHHHHhhcCccC--CCC Confidence 001122333433322111 1000 0 0 01123457789999999999999986543211 000 Q NP_000836.2 432 PR----MSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHR 507 (908) Q Consensus 432 ~~----~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~~ 507 (908) .. .....++.+.+.|++.+|.|.+| ++.||++|++...+.+.+++ ++.++.||.|+.... .+.|... T Consensus 332 ~~~~~~~~~~~~~~l~~~l~~~~f~G~~G-~v~fd~~G~r~~~~~i~~~~----~~~~~~vg~~~~~~~----~~~~~~~ 402 (762) T 6UO8_A 332 LEDFNYNNQTITDQIYRAMNSSSFEGVSG-HVVFDASGSRMAWTLIEQLQ----GGSYKKIGYYDSTKD----DLSWSKT 402 (762) T ss_dssp TTCCCSSCCTTHHHHHHHHHTCCCBCSSS-BCCCSSSSCCCCCEEEEEEE----TTEEEEEEEECSSSC----CCCCCCC T ss_pred HHHcCCCCHHHHHHHHHHHHcCcccccce-eeEeCCCCCccceEEEEEEe----CCeEEEEEEEECCCC----ceeecCC Confidence 00 01123446777888889999988 89999999998888888887 357899999986521 2344211 Q NP_000836.2 508 EHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVP 587 (908) Q Consensus 508 ~~~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s~~~~~~~ 587 (908) ..|+.|. +|.| ++.| +..+..++.++.+++ T Consensus 403 ----------~~~~~g~-------------------------------~p~d------~~~~---~~~~~~~~~~~~~~~ 432 (762) T 6UO8_A 403 ----------DKWIGGS-------------------------------PPAD------QTLV---IKTFRFLSQKLFISV 432 (762) T ss_dssp ----------CCCGGGS-------------------------------CCCC------CCCE---EEECCCCTTHHHHHH T ss_pred ----------CccCCCC-------------------------------CCCC------ccee---hhccchhCHHHHHHH Confidence 1222221 2333 4444 333445567778888 Q NP_000836.2 588 VFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFL------MIAAP-DTIICSFRRVFLGLGMC 660 (908) Q Consensus 588 ~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~------~~~~~-~~~~C~~~~~~~~~gf~ 660 (908) .++++++++++++++++++++|+++.+|+++|.+++++|+|++++|+++++ ++..+ +...|.+|.|++++||+ T Consensus 433 ~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~l~~~~l~g~~l~~~~~~~~~~~~~~i~~~~~~~~C~~~~~~~~~gf~ 512 (762) T 6UO8_A 433 SVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFS 512 (762) T ss_dssp HHHHHHHHHHHHHHHHHHHHSCCSHHHHSSCTHHHHHHHHHHHHHHTTSHHHHCCTTTTTTTCHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHccCChhHhccCHHHHHHHHHHHHHHHHhHHhhCCCCCCCCccchHHHHHHHHHHHHHhHH Confidence 899999999999999999999999999999999999999999999999986 34445 68999999999999999 Q NP_000836.2 661 FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRT----LDPEKA 736 (908) Q Consensus 661 l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~----~~~~~~ 736 (908) ++||++++|+||++++|++++.++..++.++++.++.+++++++++++++++|+.++|+..........+ .+.... T Consensus 513 l~~~~l~~k~~ri~~if~~~~~~~~~~~~~~~~~l~~~~~~~~~i~~~il~~w~~~~p~~~~~~~~~~~~~~~~~~~~~~ 592 (762) T 6UO8_A 513 LGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSIL 592 (762) T ss_dssp HHHHHHHHHHHHHHHTTSCCSSCTTCSSCSSTHHHHHHHHHHHHHHHHHHHHHHHSSCCCCEEEECCCCCCCSSSSCCEE T ss_pred HHHhhhhhcceEEEEEeecccccchhhcccCHHHHHHHHHHHHHHHHHHHHHHHHhCcccceeeecccCCCCccCCceEe Confidence 9999999999999999997654322244678899999999999999999999999999976543211000 000012 Q NP_000836.2 737 RGVLKCDISD--LSLICSLGYSILLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYI 813 (908) Q Consensus 737 ~~~~~C~~~~--~~~~~~~~~~~~ll~~~~~la~~~R~~~-~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 813 (908) .....|.+.+ .|++++++|+++|++++++|||++|++| ++|||+|+|++++|+++++|++++++++.....+ .. T Consensus 593 ~~~~~C~~~~~~~~~~~~~~~~~~ll~~~~~la~~tr~~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~---~~ 669 (762) T 6UO8_A 593 PQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQ---DA 669 (762) T ss_dssp EEEEECCCSCCTTHHHHHHHHHHHHHHHHHHHHHSCCSCCSSCSSHHHHHHHHHHHHHHHHHHHHHHHTTCCCTT---TS T ss_pred ceeeeeecCCchHHHHHHHHHHHHHHHHHHHHHHHhcCCCChhhccHHHHHHHHHHHHHHHHHHHHHHHHhcCCh---hH Confidence 2356999864 7888999999999999999999999999 9999999999999999999999999987665432 35 Q NP_000836.2 814 QTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSF 856 (908) Q Consensus 814 ~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~~~ 856 (908) .+.+.+++++++++++|+++|+||+|.++++++.+......++ T Consensus 670 ~~~~~~~~i~~~~~~~l~~~f~Pk~~~~~~~~~~~~~~~~~~~ 712 (762) T 6UO8_A 670 AFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMK 712 (762) T ss_dssp HHHHHHHHHHHHHHHHHHHHHSHHHHHHHC------------- T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccchhhhhcc Confidence 6678889999999999999999999999999988776554443 No 7 >6UO8_B Gamma-aminobutyric acid type B receptor; G protein-coupled receptor, GABA, GABAB; HET: BMA, QDA, NAG;{Homo sapiens} Probab=100.00 E-value=2.2e-64 Score=602.93 Aligned_cols=675 Identities=21% Similarity=0.307 Sum_probs=484.0 Template_Neff=10.500 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) ....+++++||+++|.++.... ...+.....|+++|++++|+++ .++|+++++.+.|+++++..+.+.+.+ T Consensus 9 ~~~~~~~i~Ig~l~p~~~~~~~--------~~~g~~~~~a~~~Av~~iN~~~-~l~~~~l~~~~~D~~~~~~~a~~~~~~ 79 (779) T 6UO8_B 9 PPPSSPPLSIMGLMPLTKEVAK--------GSIGRGVLPAVELAIEQIRNES-LLRPYFLDLRLYDTECDNAKGLKAFYD 79 (779) T ss_dssp ----CCEEEEEEECCCCSSSSS--------SHHHHHHHHHHHHHHHHHHTTC-SSTTSEEEEEEECCTTCHHHHHHHHHH T ss_pred CCCCCCCeEEEEEEEcCccccC--------CcccccHHHHHHHHHHHHHhcc-CCCCcEEEEEEecCCCChHHHHHHHHH Confidence 4566789999999999875310 0245678899999999999875 456899999999998876544433333 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) ++.. .+++++++|+.++..+.+++.+++.+++|+|+++++++.++++..+++++|+.|+ T Consensus 80 l~~~---------------------~~~v~~viG~~~s~~~~~va~~~~~~~ip~is~~ats~~ls~~~~~p~~~rt~ps 138 (779) T 6UO8_B 80 AIKY---------------------GPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPS 138 (779) T ss_dssp HHHT---------------------SCCEEEEEECCSTTHHHHHHTTCTTTTCCEEESSCCCGGGGCTTSCTTEEESSCC T ss_pred HHHh---------------------CCCEEEEEecCChHHHHHHHHHcCccCCEEEecccCChhHcCcccCCCceecCCC Confidence 3221 1368899999988888888999999999999999988888876678999999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) +..+++++++++++++|++|++++++++++....+.+++.+++. ++++.....++ .+..+.++++++ .++++| T Consensus 139 ~~~~~~a~~~~l~~~~W~~v~ii~~~~~~~~~~~~~~~~~~~~~-gi~v~~~~~~~-----~d~~~~l~~l~~-~~~~iI 211 (779) T 6UO8_B 139 DNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGE-DIEISDTESFS-----NDPCTSVKKLKG-NDVRII 211 (779) T ss_dssp TTSSHHHHHHHHTTTTCCCEEEEECSSSHHHHHHHHHHHHTSSS-SCCEEEEEECS-----SCGGGTHHHHHH-TTCCEE T ss_pred HhhhcHHHHHHHHHcCCCEEEEEEecchhHHHHHHHHHHHHHhC-CcEEEeeeeec-----CChhHHHHHHhh-CCcEEE Confidence 99999999999999999999999988888888888888877765 46665443332 234556777763 588998 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVY-------------QQEEIAEGAVTILPKRASIDGFDRY 344 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~-------------~~~~~~~g~~~~~~~~~~~~~~~~~ 344 (908) ++......+..+++++++.|+.+ +++|+..+ |........ ......+|.+.+.........+..+ T Consensus 212 v~~~~~~~~~~~l~~a~~~g~~~~~~~wi~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~ 290 (779) T 6UO8_B 212 LGQFDQNMAAKVFCCAYEENMYGSKYQWIIPG-WYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTI 290 (779) T ss_dssp EEECCHHHHHHHHHHHHHTTCCSTTCEEEEEC-CCCTTTTTTSCSSSCCTTSCSHHHHTTSCSCEEEEECSSCSSCCCCS T ss_pred EEeCCHHHHHHHHHHHHHcCCCCCcEEEEeec-CCCcchhHhhcccccCCCccHHHHHHHHCCceeeEecCCCCCCcccc Confidence 88877777888999998888754 57788764 322110000 0111223333222111000000000 Q NP_000836.2 345 FRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLC 424 (908) Q Consensus 345 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~ 424 (908) ......+ |.+.+.+... ...+..++.++|||++++++|++++....+ T Consensus 291 ----------~~~~~~~-~~~~~~~~~~----------------------~~~~~~~~~~~yDAv~~~a~al~~~~~~~~ 337 (779) T 6UO8_B 291 ----------SGKTPQQ-YEREYNNKRS----------------------GVGPSKFHGYAYDGIWVIAKTLQRAMETLH 337 (779) T ss_dssp ----------SSSCHHH-HHHHHHHHSS----------------------SCCCCSCSSTTHHHHHHHHHHHHHHHSSSC T ss_pred ----------CCCCHHH-HHHHHHhhcC----------------------CCCccccchHHHHHHHHHHHHHHHHHHHHH Confidence 0000111 1111211000 012345678899999999999999875432 Q NP_000836.2 425 PGY----IGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLH---L 497 (908) Q Consensus 425 ~~~----~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~---~ 497 (908) ... ...+.......+..+.+++++.+|.|.+| ++.|| +|++...+.+.+++ ++.++.||.|+.... + T Consensus 338 ~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~sG-~v~f~-~g~r~~~~~i~~~~----~~~~~~vg~~~~~~~~l~~ 411 (779) T 6UO8_B 338 ASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTG-QVVFR-NGERMGTIKFTQFQ----DSREVKVGEYNAVADTLEI 411 (779) T ss_dssp SHHHHHTTSCCCSCCHHHHHHHHHHHHCCCCBCSSS-BCEEE-TTEEECEEEEEEEC----SSSEEEEEEEESSSCCEEE T ss_pred hcCCCCCHHHcCCCCHHHHHHHHHHHHcCCccccce-eEEEe-CCceecEEEEEEEe----CCeEEEEEEEECCCCeEEE Confidence 110 00010111224556778888889999988 89999 89998889999988 257899999986521 1 Q NP_000836.2 498 KVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKL 577 (908) Q Consensus 498 ~~~~i~w~~~~~~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~ 577 (908) +...+.|.+ |. +|.+ ++.| ..... T Consensus 412 ~~~~~~~~~----------------~~-------------------------------~P~d------~~~~---~~~~~ 435 (779) T 6UO8_B 412 INDTIRFQG----------------SE-------------------------------PPKD------KTII---LEQLR 435 (779) T ss_dssp CTTTCCCSS----------------SS-------------------------------CCCS------SCCE---EEEEC T ss_pred ecccceeCC----------------CC-------------------------------CCCC------Ccee---eeecc Confidence 111223321 10 2333 3333 23333 Q NP_000836.2 578 EWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPD-------TIICSF 650 (908) Q Consensus 578 ~~s~~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~-------~~~C~~ 650 (908) .++.++.+++.+++++|++++++++++++++|+++.+|++++.+++++|+|++++|++++++++.++ ...|.+ T Consensus 436 ~~~~~~~~~~~~~~~~gi~~~~~~~~~~~~~r~~~~ik~s~~~~~~~il~g~~l~~~~~~~~~~~~~~~~~~~~~~~C~~ 515 (779) T 6UO8_B 436 KISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTV 515 (779) T ss_dssp CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTSTTCTTCCHHHHHHHHHHHHHHHHHHHHHCCCTTTTTTTSHHHHHHH T ss_pred cCCHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCChhHhcCCHHHHHHHHHHHHHHHHHHHHhcCCCCCCChhHHHHHHHh Confidence 5677788888899999999999888999999999999999999999999999999999999887775 689999 Q NP_000836.2 651 RRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRT 730 (908) Q Consensus 651 ~~~~~~~gf~l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~ 730 (908) |.|++++||+++||+|++|+||++++|++.+.+ ++.++++.++.+++++++++++++++|++++|+........... T Consensus 516 ~~~~~~~gf~l~~~~l~~K~~ri~~if~~~~~~---~~~~~~~~l~~~~~~~~~i~~~il~~w~~~~p~~~~~~~~~~~~ 592 (779) T 6UO8_B 516 RTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMK---KKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEP 592 (779) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHTSCCC-----CCCSCSSHHHHHHHHHHHHHHHHHHTTTTTCCCCCCCEECCCCC T ss_pred HHHHHHHHHHHHHHHhHHHHHhHHhHhcccccc---CcccCHHHHHHHHHHHHHHHHHHHHHHHHhCcccceeeeeecCC Confidence 999999999999999999999999999876543 34678888999999999999999999999999876532110000 Q NP_000836.2 731 ----LDPEKARGVLKCDIS--DLSLICSLGYSILLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIIWLAFIPIFFG 803 (908) Q Consensus 731 ----~~~~~~~~~~~C~~~--~~~~~~~~~~~~~ll~~~~~la~~~R~~~-~~~nes~~i~~~~~~~~~~~~~~~~~~~~ 803 (908) .+.........|.+. ..|++++++|+++|+++|++|||++|++| ++|||+|+|++++|+++++|+++++++++ T Consensus 593 ~~~~~~~~~~~~~~~C~~~~~~~~~~~~~~y~~~ll~~~~~la~~~r~~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~ 672 (779) T 6UO8_B 593 DPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFL 672 (779) T ss_dssp CCSSCCCEEEEEECCCCCTTTTSSSHHHHHHHHHHHHHHHHHHHHHHTSCCCTTSCSSHHHHHHHHHHHHHHHHHHHHTT T ss_pred CCCCCCceEeeeEeeecCCChHHHHHHHHHHHHHHHHHHHHHHHHhcCCCChhhcchhHHHHHHHHHHHHHHHHHHHHHH Confidence 000012345799885 37888999999999999999999999999 99999999999999999999999999876 Q NP_000836.2 804 TAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKR 852 (908) Q Consensus 804 ~~~~~~~~~~~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~ 852 (908) ....+ ...+.+.+++++++++++|+++|+||+|.++++|+.+...+ T Consensus 673 ~~~~~---~~~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~ 718 (779) T 6UO8_B 673 TRDQP---NVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNR 718 (779) T ss_dssp CCSCT---TTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC-------- T ss_pred hcCCc---hHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccCcchhhhcc Confidence 65432 35567888999999999999999999999999998876644 No 8 >7C7Q_A Gamma-aminobutyric acid type B receptor; GABAB, Cryo-EM, GPCR, active, PAM; HET: FN0, 2C0, NAG;{Homo sapiens} Probab=100.00 E-value=3.4e-62 Score=592.43 Aligned_cols=685 Identities=20% Similarity=0.285 Sum_probs=475.7 Template_Neff=10.600 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.+++. ..+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+.+ T Consensus 166 ~~~~~~i~Ig~l~p~~~~~-----------~~~~~~~~a~~~Av~~iN~~~~il~~~~l~l~~~D~~~~~~~a~~~~~~- 233 (879) T 7C7Q_A 166 HSERRAVYIGALFPMSGGW-----------PGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYE- 233 (879) T ss_dssp --CCEEEEEEEECCCSSSC-----------CTHHHHHHHHHHHHHHHHHCTTTCSSEEEEEEEECCTTCHHHHHHHHHH- T ss_pred CccCCceEEEeEecCCCCC-----------CCccchHHHHHHHHHHHHhCCCCCCCCEEEEEEcCCCCChHHHHHHHHH- Confidence 3456889999999998743 1356678999999999999888888999999999998876544333333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++. ++++++++|+.++..+..++.+++..++|+|++.++++.++++..+++++|+.|++ T Consensus 234 ---l~~------------------~~~v~~viG~~~s~~~~~~a~~~~~~~ip~is~~a~s~~ls~~~~~~~~~r~~ps~ 292 (879) T 7C7Q_A 234 ---LLY------------------NDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSA 292 (879) T ss_dssp ---HHT------------------SSSCEEEEEECSHHHHHHHHHHGGGTTCEEEESSCCCGGGGCTTTSTTEEESSCCG T ss_pred ---HHh------------------CCCeEEEEEcCChHHHHHHHHHHHhcCCEEEecccCChhhhccccCCceEEcCCCh Confidence 322 15788999998888777888899999999999998877777666789999999999 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) ..+++++++++++++|++|++++++++++....+.+++.+++. ++++.....+. .+....++++++ .++|+|+ T Consensus 293 ~~~~~a~~~~l~~~~w~~v~ii~~~~~~g~~~~~~~~~~~~~~-gi~v~~~~~~~-----~~~~~~l~~l~~-~~~~vIv 365 (879) T 7C7Q_A 293 TLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEA-GIEITFRQSFF-----SDPAVPVKNLKR-QDARIIV 365 (879) T ss_dssp GGHHHHHHHHHHHTTCCEEEEEEESCHHHHHHHHHHHHHHHHH-TCEEEEEEEES-----SCCHHHHHHHHH-TTCCEEE T ss_pred hhccHHHHHHHHHhCCCEEEEEEECCCcchHHHHHHHHHHHHc-CcEEEEEeccc-----CCchHHHHHHHh-CCCEEEE Confidence 9999999999989999999999988888888888888888775 46765443332 133455666763 5889998 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQSG-HFLWIGSD----SWGSKIAP-----VYQQEEIAEGAVTILPKRASIDGFDRYFRSRT 349 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~----~~~~~~~~-----~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~ 349 (908) +......+..+++++++.|+.+ ++.|+..+ .|...... ........+|.+....... ... T Consensus 366 ~~~~~~~~~~~l~~a~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~---------~~~- 435 (879) T 7C7Q_A 366 GLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVML---------NPA- 435 (879) T ss_dssp EECCHHHHHHHHHHHHHHTCCSSSCEEEEETTSCTTTTTSCCTTCCSCHHHHHHHSSSCEEEEECCS---------CCS- T ss_pred EecCHHHHHHHHHHHHHcccCCCCEEEEEecccccccccccCCCCCCCHHHHHHHHcCcEEEEeecc---------CCC- Confidence 8877777888999998888754 46777653 22211000 0000112223222111000 000 Q NP_000836.2 350 LANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYI- 428 (908) Q Consensus 350 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~- 428 (908) ......+.++.++++++... .... + . ......++..+|||++++++|++++....+.... T Consensus 436 ~~~~~~~~~~~~f~~~~~~~-~~~~---~----~-----------~~~~~~~~~~~yDAv~~~a~Al~~~~~~~~~~~~~ 496 (879) T 7C7Q_A 436 NTRSISNMTSQEFVEKLTKR-LKRH---P----E-----------ETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVR 496 (879) T ss_dssp CCCCTTSCCHHHHHHHHHHH-SSSC---G----G-----------GSTTTTSHHHHHHHHHHHHHHHHHTC--------C T ss_pred CCcccCCCCHHHHHHHHHHH-HhcC---C----c-----------cCCCCcccchHHHHHHHHHHHHHHHhcccccCCCC Confidence 00000122333333322111 1000 0 0 0112345778999999999999998754321100 Q NP_000836.2 429 GLCPR-MSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHR 507 (908) Q Consensus 429 ~~~~~-~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~~ 507 (908) ..+.. .....++.+.++|++.+|.|.+| ++.||++|++...+.+.+++ ++.++.+|.|+.... .+.|... T Consensus 497 ~~~~~~~~~~~~~~l~~~l~~~~f~G~~G-~v~fd~~G~r~~~~~i~~~~----~~~~~~vg~~~~~~~----~~~~~~~ 567 (879) T 7C7Q_A 497 LEDFNYNNQTITDQIYRAMNSSSFEGVSG-HVVFDASGSRMAWTLIEQLQ----GGSYKKIGYYDSTKD----DLSWSKT 567 (879) T ss_dssp CTTCCTTCCHHHHHHHHHHHTCEEEETTE-EEECCSSCCCCCEEEEEEEC----SSSEEEEEEEETTTT----EEEECSC T ss_pred HHHCCCCCHHHHHHHHHHHHcCcccccee-eEEeCCCCCccceEEEEEEe----CCEEEEEEEEECCCC----ceeeccC Confidence 00000 01123456778888889999988 89999999998888888887 357899999986521 2344211 Q NP_000836.2 508 EHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVP 587 (908) Q Consensus 508 ~~~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s~~~~~~~ 587 (908) ..|+.|. +|.+ .+.| ...+..++..+.+++ T Consensus 568 ----------~~w~~g~-------------------------------~p~~------~~~~---~~~~~~~~~~~~i~~ 597 (879) T 7C7Q_A 568 ----------DKWIGGS-------------------------------PPAD------QTLV---IKTFRFLSQKLFISV 597 (879) T ss_dssp ----------CCCTTSS-------------------------------CCCS------SCCE---EEEECCCCHHHHHHH T ss_pred ----------CccCCCC-------------------------------CCcc------ccee---eeecchhCHHHHHHH Confidence 1222221 2333 3333 233445556777888 Q NP_000836.2 588 VFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFL------MIAAP-DTIICSFRRVFLGLGMC 660 (908) Q Consensus 588 ~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~------~~~~~-~~~~C~~~~~~~~~gf~ 660 (908) .++++++++++++++++++++|+++.+|++++.+++++|+|++++|+++++ ++..| +...|.+|.|++++||+ T Consensus 598 ~~~~~~~i~~~~~~~~~~~~~r~~~~i~~~~~~l~~~il~g~~l~~~~~~~~~~~~~~~~~~~~~~~C~~~~~~~~~~f~ 677 (879) T 7C7Q_A 598 SVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFS 677 (879) T ss_dssp HHHHHHHHHHHHHHHHHHHHTSSSSGGGGSCHHHHHHHHHHHHHHHHTHHHHHCCTTTSCSTTTHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHcccChhHhccCHHHHHHHHHHHHHHHHHHHHhcCCccCCCccchhHHHHHHHHHHHHhHH Confidence 888999998888888889999999999999999999999999999999986 34445 68899999999999999 Q NP_000836.2 661 FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRT----LDPEKA 736 (908) Q Consensus 661 l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~----~~~~~~ 736 (908) ++||+|++|+||++++|++++.++.+++.++++.++.++++++++|++++++|++++|+..........+ .+.... T Consensus 678 l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~il~~w~~~~p~~~~~~~~~~~~~~~~~~~~~~ 757 (879) T 7C7Q_A 678 LGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSIL 757 (879) T ss_dssp HHHSTTTHHHHHHHHHCC-----------CCTTHHHHHHHHHHHHHHHHHHHHHHHSCCEEEEEECCCCCCTTSSSCEEE T ss_pred HHHHHHhccceEEEEEeecccccchhhccCCHHHHHHHHHHHHHHHHHHHHHHHHhCcccceeeecccCCCCcCCCeeEe Confidence 9999999999999999997654322234678888999999999999999999999999976543211000 000012 Q NP_000836.2 737 RGVLKCDISD--LSLICSLGYSILLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYI 813 (908) Q Consensus 737 ~~~~~C~~~~--~~~~~~~~~~~~ll~~~~~la~~~R~~~-~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 813 (908) .....|.+.+ .+++++++|+++|++++++|||++|++| ++|||+|+|++++|+++++|+++++++++..... .. T Consensus 758 ~~~~~C~~~~~~~~~~~~~~~~~~ll~~~~~la~~tR~~~~~~~nesk~i~~~~~~~~~~~~~~~~~~~~~~~~~---~~ 834 (879) T 7C7Q_A 758 PQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQ---DA 834 (879) T ss_dssp EEEEEEECSSCSSHHHHHHHHHHHHHHHHHHHHHHTSSCCCSSSSCHHHHHHHHHHHHHHHHHHHHHHHHSTTCH---HH T ss_pred ceEeEeecCCchHHHHHHHHHHHHHHHHHHHHHHHhcCCCchhhccHHHHHHHHHHHHHHHHHHHHHHHHhcCCh---HH Confidence 2367999864 6778899999999999999999999999 9999999999999999999999999987665432 24 Q NP_000836.2 814 QTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRS 855 (908) Q Consensus 814 ~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~~ 855 (908) .+.+.+++++++++++|+++|+||+|.++++++++..++... T Consensus 835 ~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~~ 876 (879) T 7C7Q_A 835 AFAFASLAIVFSSYITLVVLFVPKMRRLITEVLFQGPHHHHH 876 (879) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC------------ T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccccCCCCCCCC Confidence 566888999999999999999999999999998887665443 No 9 >2E4U_A Metabotropic glutamate receptor 3; G-protein-coupled receptor, neuron, central nerve; HET: GLU, NAG; 2.35A {Rattus norvegicus} Probab=100.00 E-value=1.2e-43 Score=406.76 Aligned_cols=535 Identities=46% Similarity=0.875 Sum_probs=346.7 Template_Neff=11.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...+++++||+++|.++.......|+......+.....|+++|++++|+++++++|+++++.+.|++++...+.+.+.++ T Consensus 9 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~g~~~~~a~~~Av~~iN~~~~~l~~~~l~~~~~D~~~~~~~a~~~~~~~ 88 (555) T 2E4U_A 9 IKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEF 88 (555) T ss_dssp EEECCSEEEEEEECCEEECCTTCSEEEECCCCCCCHHHHHHHHHHHHHHCTTSSTTCCEEEEEEECTTCHHHHHHHHHHH T ss_pred eEecCCEEEEeeecceecCCCCCCccccccccCHHHHHHHHHHHHHHhcCCCCCCCCeeeEEEeeCCCCHHHHHHHHHHH Confidence 45578999999999987543233455333345677889999999999999888889999999999988765544444443 Q NP_000836.2 120 VQALIEK-DASDVKCANGDPPIFTK-PDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 120 ~~~l~~~-~~~~~~~~~~~~~~~~~-~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +...... ......|....+.+... ..+++++||+.++..+..++.++..+++|+|++++.++.++++..+++++++.| T Consensus 89 ~~~~~~~~~~~~~~c~~~~~~~~~~~~~~v~~viG~~~s~~~~~~~~~~~~~~ip~is~~~~~~~l~~~~~~~~~~r~~p 168 (555) T 2E4U_A 89 VRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVP 168 (555) T ss_dssp HHTTC--------------------CCCCEEEEEECSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTTCTTEEESSC T ss_pred HHHhccCcccccccCCCCCcccccCCCCcEEEEEcCCChHHHHHHHHHhHhhCCCEEecCcCCcccCCCCcCCCccccCC Confidence 3210000 00000000000000000 035789999988888888889999999999999887777766556899999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ++..+++++++++++++|++|++|+.+++++....+.+.+.+++. ++++.....++......++...++++++..++++ T Consensus 169 ~~~~~~~~l~~~l~~~~w~~v~~i~~~~~~g~~~~~~~~~~~~~~-~i~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v 247 (555) T 2E4U_A 169 PDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLR-NICIATAEKVGRSNIRKSYDSVIRELLQKPNARV 247 (555) T ss_dssp CHHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHTT-TCEEEEEEEECTTCCHHHHHHHHHHHHTCTTCCE T ss_pred CHHHHHHHHHHHHHHcCCCEEEEEEEcCcchHHHHHHHHHHHHHC-CCEEEEEEEeccccccccHHHHHHHHHhCCCccE Confidence 999999999999999999999999988888888888888887765 4666543333211112345555666632247888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) |++.+....+..+++++.+.|+ ++.|++.+.|...............+.+.+.......++|..|+....+...+.+. T Consensus 248 vv~~~~~~~~~~~~~~~~~~~~--~~~~i~~~~~~~~~~~~~~~~~~~~g~l~~~~~~~~~~~f~~fl~~~~~~~~~~~~ 325 (555) T 2E4U_A 248 VVLFMRSDDSRELIAAANRVNA--SFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNP 325 (555) T ss_dssp EEEECCHHHHHHHHHHHHHTTC--CCEEEECTTTTTCGGGTTTCHHHHTTCEEEEECCCCCHHHHHHHHTCCTTTCTTCT T ss_pred EEEECCHHHHHHHHHHHHHcCC--CeEEEEeCcccccchhhcCCcceeceEEEEEEcCCCCccHHHHHHhCCCCcCCCCH Confidence 8888777778888888887776 36788876665432110001123344444443333334455444332222223455 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTI 437 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~ 437 (908) ++.++|++.++|..... ......|+..+..... ......++.++||||+++|+||+++....+......|...... T Consensus 326 ~~~~~~~~~~~c~~~~~---~~~~~~c~~~~~~~~~-~~~~~~~~~~~ydAv~~~a~aL~~~~~~~~~~~~~~c~~~~~~ 401 (555) T 2E4U_A 326 WFRDFWEQKFQCSLQNK---RNHRQVCDKHLAIDSS-NYEQESKIMFVVNAVYAMAHALHKMQRTLCPQTTKLCDAMKIL 401 (555) T ss_dssp THHHHHHHHTTCCCC---------CCCCTTCCCCTT-TCCCCTTHHHHHHHHHHHHHHHHHHHHHHCTTCSSCCGGGTSC T ss_pred HHHHHHHHHcCCccCCc---cCCCcccCCCcccCCC-CccchhhHHHHHHHHHHHHHHHHHHHhccCCCCCCCchhhccc Confidence 67777777666532110 0011123322111100 0122345678999999999999998764332111122211111 Q NP_000836.2 438 DGKE-LLGYIRAVNFN-------GSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREH 509 (908) Q Consensus 438 ~~~~-l~~~l~~~~f~-------G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~~~~ 509 (908) ++.. +.+.|++..|. |.+| .+.||++|++...|.|++++..++...++.||.|+....++...+.|.++ T Consensus 402 ~~~~~~~~~l~~~~f~~~~~~~~g~~g-~v~fd~~G~~~~~~~i~~~~~~~~~~~~~~vg~~~~~~~~~~~~i~W~~~-- 478 (555) T 2E4U_A 402 DGKKLYKEYLLKIQFTAPFNPNKGADS-IVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRN-- 478 (555) T ss_dssp CHHHHHHHHTTCEEECCSSSCCSSSCC-EEECCTTSCCCCCEEEEEEECTTSSCEEEEEEEESSSEECCGGGCCCTTS-- T ss_pred ChhHHHHHHHHhCcccCCCCCCCCCCC-eeEeCCCCCCCceEEEEEEEeeCCeEEEEEEEEeCCcEEEecccccccCC-- Confidence 2232 44677777773 6677 89999999998889999887432223688999998654344346889753 Q NP_000836.2 510 THPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWA 584 (908) Q Consensus 510 ~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s~~~~ 584 (908) ..|.++|+.+|++|++|...+++.|||+|..|++++++++.++|.+||.++|||.+++.|.+++..|+.|.+++. T Consensus 479 ~~P~s~Cs~~C~~G~~k~~~~~~~Cc~~C~~C~~~~~~~~~~~C~~Cp~~~~~n~~~~~C~~~~~~~L~~~~~~~ 553 (555) T 2E4U_A 479 SVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDALV 553 (555) T ss_dssp SCCCCCSSCCCCTTTEEEECCSSSSCCEEEECCTTEEEEETTEEEECCTTEEECTTSSSEEECCC---------- T ss_pred CCCcceeeCCCCCCceeecCCCCcccceeeecccceeecCceeecCCCCCcccCCCCCCeEeccccccCcccCCC Confidence 568999999999999988766678999999999999998789999999999999999999999999999887653 No 10 >2E4X_B Metabotropic glutamate receptor 3; G-protein-coupled receptor, neuron, central nerve; HET: C5B, NAG; 2.75A {Rattus norvegicus} Probab=100.00 E-value=1.2e-43 Score=406.76 Aligned_cols=535 Identities=46% Similarity=0.875 Sum_probs=347.2 Template_Neff=11.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...+++++||+++|.++.......|+......+.....|+++|++++|+++++++|+++++.+.|++++...+.+.+.++ T Consensus 9 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~g~~~~~a~~~Av~~iN~~~~~l~~~~l~~~~~D~~~~~~~a~~~~~~~ 88 (555) T 2E4X_B 9 IKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEF 88 (555) T ss_dssp EEECCSEEEEEEECCEEECCTTCSEEEECCCCCCCHHHHHHHHHHHHTTCSSSSTTCCEEEEEEECTTCHHHHHHHHHHH T ss_pred eEecCCEEEEeeecceecCCCCCCccccccccCHHHHHHHHHHHHHHhcCCCCCCCCeeeEEEeeCCCCHHHHHHHHHHH Confidence 45578999999999987543233455333345677889999999999999888889999999999988765544444443 Q NP_000836.2 120 VQALIEK-DASDVKCANGDPPIFTK-PDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 120 ~~~l~~~-~~~~~~~~~~~~~~~~~-~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +...... ......|....+.+... ..+++++||+.++..+..++.++..+++|+|++++.++.++++..+++++++.| T Consensus 89 ~~~~~~~~~~~~~~c~~~~~~~~~~~~~~v~~viG~~~s~~~~~~~~~~~~~~ip~is~~~~~~~l~~~~~~~~~~r~~p 168 (555) T 2E4X_B 89 VRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVP 168 (555) T ss_dssp HHHTC--------------------CCCCEEEEEECSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTTCTTEEESSC T ss_pred HHHhccCcccccccCCCCCcccccCCCCcEEEEEcCCChHHHHHHHHHhHhhCCCEEecCcCCcccCCCCcCCCccccCC Confidence 3210000 00000000000000000 035789999988888888889999999999999887777766556899999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ++..+++++++++++++|++|++|+.+++++....+.+.+.+++. ++++.....++......++...++++++..++++ T Consensus 169 ~~~~~~~~l~~~l~~~~w~~v~~i~~~~~~g~~~~~~~~~~~~~~-~i~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v 247 (555) T 2E4X_B 169 PDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLR-NICIATAEKVGRSNIRKSYDSVIRELLQKPNARV 247 (555) T ss_dssp CHHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHT-TCEEEEEEEECTTCCHHHHHHHHHHHHTCTTCCE T ss_pred CHHHHHHHHHHHHHHcCCCEEEEEEEcCcchHHHHHHHHHHHHHC-CCEEEEEEEeccccccccHHHHHHHHHhCCCccE Confidence 999999999999999999999999988888888888888887765 4666543333211112345555666632247888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) |++.+....+..+++++.+.|+ ++.|++.+.|...............+.+.+.......++|..|+....+...+.+. T Consensus 248 vv~~~~~~~~~~~~~~~~~~~~--~~~~i~~~~~~~~~~~~~~~~~~~~g~l~~~~~~~~~~~f~~fl~~~~~~~~~~~~ 325 (555) T 2E4X_B 248 VVLFMRSDDSRELIAAANRVNA--SFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNP 325 (555) T ss_dssp EEEECCHHHHHHHHHHHHHTTC--CCEEEECTTTTTCSTTTTTCTTTSTTCEEEEECCCCCHHHHHHHHTCCTTTCTTCT T ss_pred EEEECCHHHHHHHHHHHHHcCC--CeEEEEeCcccccchhhcCCcceeceEEEEEEcCCCCccHHHHHHhCCCCcCCCCH Confidence 8888777778888888887776 36788876665432110001123344444443333334455444332222223455 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTI 437 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~ 437 (908) ++.++|++.++|..... ......|+..+..... ......++.++||||+++|+||+++....+......|...... T Consensus 326 ~~~~~~~~~~~c~~~~~---~~~~~~c~~~~~~~~~-~~~~~~~~~~~ydAv~~~a~aL~~~~~~~~~~~~~~c~~~~~~ 401 (555) T 2E4X_B 326 WFRDFWEQKFQCSLQNK---RNHRQVCDKHLAIDSS-NYEQESKIMFVVNAVYAMAHALHKMQRTLCPQTTKLCDAMKIL 401 (555) T ss_dssp THHHHHHHHTTCCSSSS---SSCCCCCCTTCCCCTT-TCCCCTTHHHHHHHHHHHHHHHHHHHHHHCCSCSSCCGGGSSC T ss_pred HHHHHHHHHcCCccCCc---cCCCcccCCCcccCCC-CccchhhHHHHHHHHHHHHHHHHHHHhccCCCCCCCchhhccc Confidence 67777777666532110 0011123322111100 0122345678999999999999998764332111122211111 Q NP_000836.2 438 DGKE-LLGYIRAVNFN-------GSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREH 509 (908) Q Consensus 438 ~~~~-l~~~l~~~~f~-------G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~~~~ 509 (908) ++.. +.+.|++..|. |.+| .+.||++|++...|.|++++..++...++.||.|+....++...+.|.++ T Consensus 402 ~~~~~~~~~l~~~~f~~~~~~~~g~~g-~v~fd~~G~~~~~~~i~~~~~~~~~~~~~~vg~~~~~~~~~~~~i~W~~~-- 478 (555) T 2E4X_B 402 DGKKLYKEYLLKIQFTAPFNPNKGADS-IVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRN-- 478 (555) T ss_dssp CHHHHHHHHTTCCEECTTTSCCSSSCC-EECCCSSSCCCCCEEEEEEECTTSSCEEEEEEEESSSEECCGGGCCCGGG-- T ss_pred ChhHHHHHHHHhCcccCCCCCCCCCCC-eeEeCCCCCCCceEEEEEEEeeCCeEEEEEEEEeCCcEEEecccccccCC-- Confidence 2232 44677777773 6677 89999999998889999887432223688999998654344346889753 Q NP_000836.2 510 THPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWA 584 (908) Q Consensus 510 ~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s~~~~ 584 (908) ..|.++|+.+|++|++|...+++.|||+|..|++++++++.++|.+||.++|||.+++.|.+++..|+.|.+++. T Consensus 479 ~~P~s~Cs~~C~~G~~k~~~~~~~Cc~~C~~C~~~~~~~~~~~C~~Cp~~~~~n~~~~~C~~~~~~~L~~~~~~~ 553 (555) T 2E4X_B 479 SVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDALV 553 (555) T ss_dssp SCCCCCSSCCCCSSSCEEECCSSSSCCEEECCCTTEEEEETTEEEECCTTEEECTTSSSEEECCC---------- T ss_pred CCCcceeeCCCCCCceeecCCCCcccceeeecccceeecCceeecCCCCCcccCCCCCCeEeccccccCcccCCC Confidence 568999999999999988766678999999999999998789999999999999999999999999999887653 No 11 >6N50_A Metabotropic glutamate receptor 5, Nanobody; Cell Surface Receptor, SIGNALING PROTEIN; HET: NAG, QUS; 3.751A {Homo sapiens} Probab=100.00 E-value=4.1e-43 Score=405.56 Aligned_cols=536 Identities=41% Similarity=0.786 Sum_probs=353.0 Template_Neff=10.900 Q NP_000836.2 36 YAHSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTY 111 (908) Q Consensus 36 ~~~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~ 111 (908) .......+++++||+++|.++... ....|+......+.....|+++|++++|+++++++|+++++++.|+++++.. T Consensus 42 ~~~~~~~~~~i~Ig~l~p~~~~~~~~~~~~~~cg~~~~~~g~~~~~a~~~Ai~~iN~~~~~l~~~~l~~~i~D~~~~~~~ 121 (596) T 6N50_A 42 RRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAV 121 (596) T ss_pred cceeeEcCCCEEEEEEeecccCCCCCCCCcCCcccccccccHHHHHHHHHHHHHHHcCCCCCCCCeeEEEEEeCCCCHHH Confidence 334456789999999999985311 1234553222356778899999999999998888899999999999887655 Q NP_000836.2 112 ALEQSLTFVQALIEKD---ASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTR 188 (908) Q Consensus 112 a~~~~~~~~~~l~~~~---~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~ 188 (908) +.+.+.+++....... .....|.+.++.+....++++++||+.++..+..++.++...++|+|++++.++.++++.. T Consensus 122 a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~aviG~~~s~~~~~~~~~~~~~~ip~is~~~~~~~ls~~~~ 201 (596) T 6N50_A 122 ALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTL 201 (596) T ss_pred HHHHHHHHHhcCCCCccccccceecCCCCccccccCCCeeEEECCCChHHHHHHHHHHHHhCCCeeeccCCChhhCCCCC Confidence 5444444432100000 0000000000000011257889999988877778888899999999999887777666556 Q NP_000836.2 189 YDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKR 268 (908) Q Consensus 189 ~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~ 268 (908) +++++++.|++..++.++++++++++|++|++|+.+++++....+.+++.+++. ++++.....+.......++...+++ T Consensus 202 ~~~~~r~~p~~~~~~~al~~~l~~~~w~~v~ii~~~~~~g~~~~~~~~~~~~~~-~~~i~~~~~~~~~~~~~~~~~~~~~ 280 (596) T 6N50_A 202 FKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKE-GICIAHSYKIYSNAGEQSFDKLLKK 280 (596) T ss_pred CCcccccCCCHHHHHHHHHHHHHHhCCCEEEEEEecCccchHHHHHHHHHHHHC-CcEEEEEEEeCCCCCccchHHHHHH Confidence 899999999999999999999998999999999988788888888888888775 4666543322211122345566676 Q NP_000836.2 269 LLE-TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRS 347 (908) Q Consensus 269 l~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~ 347 (908) +++ ..+.++|++......+..+++++.+.|+.+++.|++.+.|...............+.+.+.......++|..|+.. T Consensus 281 i~~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~I~~~~~~~~~~~~~~~~~~~~g~l~~~~~~~~~~~f~~f~~~ 360 (596) T 6N50_A 281 LTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLK 360 (596) T ss_pred HHHcCCCcEEEEEECCHHHHHHHHHHHHHcCCCCCEEEEEecCccccccccCCCccccccccccCCCCCCCCCHHHHHHh Confidence 653 1244555655556667788888888887544667777655432211000111233434443333334445555443 Q NP_000836.2 348 RTLANNRRNVWFAEFWEENFGCKLGSHGKR-NSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG 426 (908) Q Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~ 426 (908) ..+...+.+.++.++|++.++|........ ..+...|+....... ......++.++||||+++|+|++++....+.. T Consensus 361 ~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~ydAV~~~a~al~~~~~~~~~~ 438 (596) T 6N50_A 361 LRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKT--HHVQDSKMGFVINAIYSMAYGLHNMQMSLCPG 438 (596) T ss_pred cCCCCCCCCHHHHHHHHHHcCCCCCCCccccccCCCCCCCCccccc--CCCCccchHHHHHHHHHHHHHHHHHHhccCCC Confidence 322223345677788877766532210000 001112332211110 01123456789999999999999987543321 Q NP_000836.2 427 YIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVEDMQW 504 (908) Q Consensus 427 ~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~~i~w 504 (908) ....|......++..+.++|++.+|.|.+|..+.||++|++...|.|++++..+ +...++.||.|+... .++ ..+.| T Consensus 439 ~~~~c~~~~~~~~~~l~~~l~~~~f~g~~G~~v~fd~~G~~~~~y~i~~~~~~~~~~~~~~~VG~~~~~~l~~~-~~i~W 517 (596) T 6N50_A 439 YAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD-DDEVW 517 (596) T ss_pred CCCCCccCCCCCHHHHHHHHhcCceecCCCCeEEeCCCCCCCCCEEEEEEEEcCCCcEEEEEEEEEcCCceEEe-cceec Confidence 111222112235566778899899999888349999999998899999998532 223689999998652 122 13689 Q NP_000836.2 505 AHREHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIK 576 (908) Q Consensus 505 ~~~~~~~p~s~Cs~~c~~G~~k~~~~~-~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~ 576 (908) .++ ...|.++|+++|++|++|...++ +.|||+|.+|++++++++.++|.+||.++|||++++.|.+++... T Consensus 518 ~~~-~~~P~s~Cs~~C~~G~~~~~~~~~~~CC~~C~~C~~~~~s~~~~~C~~Cp~~~~~n~~~t~C~~~~~~~ 589 (596) T 6N50_A 518 SKK-SNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQH 589 (596) T ss_pred CCC-CCCCCceecCCCCCCceeCCCCCCCCCCcceecCCCCceeCCCCceecCCCCcCCCCCCCCEEEccCCc Confidence 753 36699999999999999988777 789999999999999987799999999999999999998776543 No 12 >6N4Y_C Metabotropic glutamate receptor 5, Nanobody; Cell Surface Receptor Nanobody, MEMBRANE; HET: FUC, MAN, NAG, BMA; 3.262A {Homo sapiens} Probab=100.00 E-value=4.4e-43 Score=405.35 Aligned_cols=536 Identities=41% Similarity=0.786 Sum_probs=309.2 Template_Neff=10.900 Q NP_000836.2 36 YAHSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTY 111 (908) Q Consensus 36 ~~~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~ 111 (908) .......+++++||+++|.++... ....|+......+.....|+++|++++|+++++++|+++++++.|++++... T Consensus 42 ~~~~~~~~~~i~Ig~l~p~~~~~~~~~~~~~~cg~~~~~~g~~~~~a~~~Av~~iN~~~~~l~~~~l~~~i~D~~~~~~~ 121 (596) T 6N4Y_C 42 RRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAV 121 (596) T ss_dssp -CCCEEECCSEEEEEEECCBCCCCTTTTTTTCCCSBCCCCCCHHHHHHHHHHHHHHHCSSSSTTCCEEEEEEECTTCHHH T ss_pred CeEEEEecCCEEEEeeeecccCCCccccccCCccccccccCHHHHHHHHHHHHHHhcCCCCCCCCeeeeEEeeCCCCHHH Confidence 334456789999999999985210 1234553222456778899999999999998888899999999999887655 Q NP_000836.2 112 ALEQSLTFVQALIEKD---ASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTR 188 (908) Q Consensus 112 a~~~~~~~~~~l~~~~---~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~ 188 (908) +.+.+.+++....... .....|.+.++.+....++++++||+.++..+..++.++...++|+|++++.++.++++.. T Consensus 122 a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~aviG~~~s~~~~~~~~~~~~~~ip~is~~~~~~~l~~~~~ 201 (596) T 6N4Y_C 122 ALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTL 201 (596) T ss_dssp HHHHHHHHHTGGGC-------------------CCCCCEEEEECCSSHHHHHHHHHHHTTTTCCEEESSCCCGGGGCTTT T ss_pred HHHHHHHHHHHhcCCcccccceeeccCCCcccccCCCCeEEEECCCCcHHHHHHHHHHHHhCCCEEeccCCCcccCCccc Confidence 5444444432100000 0000000000000001257889999988877778888899999999999887777766556 Q NP_000836.2 189 YDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKR 268 (908) Q Consensus 189 ~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~ 268 (908) +++++++.|++..++.++++++++++|++|++|+.++.++....+.+++.+++. ++++.....+.......++...+++ T Consensus 202 ~~~~~r~~p~~~~~~~al~~~l~~~~w~~v~ii~~~~~~g~~~~~~~~~~~~~~-~~~i~~~~~~~~~~~~~~~~~~~~~ 280 (596) T 6N4Y_C 202 FKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKE-GICIAHSYKIYSNAGEQSFDKLLKK 280 (596) T ss_dssp CTTEEESSCCHHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEECTTSHHHHHHHHHHH T ss_pred CCcccccCCCHHHHHHHHHHHHHHcCCCEEEEEEeCCcchHHHHHHHHHHHHHc-CceEEEEEEecccCChHHHHHHHHH Confidence 899999999999999999999988999999999988788888888888888775 4666543322211122345566666 Q NP_000836.2 269 LLE-TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRS 347 (908) Q Consensus 269 l~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~ 347 (908) +++ ..+.++|++......+..+++++.+.|+..++.|++.+.|...............+.+.+.......+.|..|+.. T Consensus 281 i~~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~I~~~~~~~~~~~~~~~~~~~~g~l~~~~~~~~~~~f~~fl~~ 360 (596) T 6N4Y_C 281 LTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLK 360 (596) T ss_dssp HHHHTTTCCEEEEECCHHHHHHHHHHHHHTTCTTSCEEEECGGGSSCHHHHTTCHHHHTTCEEEEECCCCCHHHHHHHTT T ss_pred HHhcCCCeeEEEEECChHHHHHHHHHHHHhCCCCCEEEEEecccccccccccccccccccceeeeccCCCCccHHHHHHh Confidence 653 1244555655556667788998888887544667777655432211000111223334333333333445555433 Q NP_000836.2 348 RTLANNRRNVWFAEFWEENFGCKLGSHGKR-NSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG 426 (908) Q Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~ 426 (908) ..+...+.+.++.++|++.++|........ ......|+....... ......++.++||||+++|+|++++....+.. T Consensus 361 l~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~ydAV~~~a~al~~~~~~~~~~ 438 (596) T 6N4Y_C 361 LRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKT--HHVQDSKMGFVINAIYSMAYGLHNMQMSLCPG 438 (596) T ss_dssp CCTTTCCSCTTHHHHHHHHTTEECTTCTTCCTTCSEECCTTCCTTT--TCCCCTTHHHHHHHHHHHHHHHHHHHHHHSTT T ss_pred cCcccCCCCHHHHHHHHHHcCCCCCCCCcccccccccCCCcceecc--cccccccHHHHHHHHHHHHHHHHHHHhhhCCC Confidence 322223345677788877666532110000 001112332211110 01123456679999999999999987543321 Q NP_000836.2 427 YIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVEDMQW 504 (908) Q Consensus 427 ~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~~i~w 504 (908) ....|......++..+.++|++.+|.|.+|..+.||++|++...|.|.+++..+ +...++.||.|+... .++ ..+.| T Consensus 439 ~~~~c~~~~~~~~~~l~~~l~~~~f~g~~G~~v~fd~~G~~~~~y~i~~~~~~~~~~~~~~~VG~~~~~~l~~~-~~i~W 517 (596) T 6N4Y_C 439 YAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD-DDEVW 517 (596) T ss_dssp CSSCCGGGSSCCHHHHHHHHHTCEEECTTSCEEECCTTSCCCCEEEEEEEEEEETTEEEEEEEEEEETTEEEEC-TTC-- T ss_pred CCCCccccCCCCHHHHHHHHhcCeeecCCCCEEEeCCCCCCCcceEEEEEEEcCCCeeEEEEEEEEeCCceEEc-ccccc Confidence 112222112234566778899899999888349999999998899999998532 223689999998652 122 13689 Q NP_000836.2 505 AHREHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIK 576 (908) Q Consensus 505 ~~~~~~~p~s~Cs~~c~~G~~k~~~~~-~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~ 576 (908) .++ ...|.++|+.+|++|++|...++ +.|||+|.+|++++++++.++|.+||.++|||++++.|.+++... T Consensus 518 ~~~-~~~P~s~Cs~~C~~G~~k~~~~~~~~CC~~C~~C~~~~~s~~~~~C~~Cp~~~~~n~~~t~C~~~~~~~ 589 (596) T 6N4Y_C 518 SKK-SNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQH 589 (596) T ss_dssp -------CCCCSSCCC----CEEECCSSCTTCCEEEC------------------------------------ T ss_pred ccC-CCCcceeecCCCCCCeEEeeeCCCCccccceeecCCCeEecCCceeccCCCCcccCccCCCeEEccCCc Confidence 763 36699999999999999988777 789999999999999987799999999999999999998776543 No 13 >5K5S_B Extracellular calcium-sensing receptor; Venus Flytrap module, cysteine-rich domain; HET: TRP, PO4, NAG; 2.6A {Homo sapiens} Probab=100.00 E-value=1.3e-42 Score=402.94 Aligned_cols=534 Identities=32% Similarity=0.555 Sum_probs=352.3 Template_Neff=10.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGER----------GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSR 108 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~----------~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~ 108 (908) .....++++||+++|.++.... ...|+... ..+.+...|+.+|++++|+++++++|+++++.+.|++++ T Consensus 25 ~~~~~~~i~Ig~l~p~~~~~~~~~~~~~~~~~~~~c~~~~-~~~~~~~~a~~~Av~~iN~~~~~l~~~~l~~~~~D~~~~ 103 (615) T 5K5S_B 25 RAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYN-FRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNT 103 (615) T ss_dssp EEEECCSEEEEEEECSBSCBCCCCCCCSSCCCCCCBCSBC-HHHHHHHHHHHHHHHHHHHCSSSCSSCCEEEEEEECTTC T ss_pred ceEecCCEEEEeeeeceecccCCCCCcccCCCcccceeec-cccHHHHHHHHHHHHHHhcCCCCCCCCceeEEEEcCCCC Confidence 3567789999999999874321 12343211 245678899999999999998888999999999999887 Q NP_000836.2 109 DTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTR 188 (908) Q Consensus 109 ~~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~ 188 (908) ...+.+.+.+++... .....+....+.+....+++.++||+.++..+..++.++...++|+|++.+.++.++++.. T Consensus 104 ~~~a~~~~~~l~~~~----~~~~~~~~~~~~~~~~~~~v~~viG~~~s~~~~~~~~~~~~~~iP~is~~~~~~~l~~~~~ 179 (615) T 5K5S_B 104 VSKALEATLSFVAQN----KIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQ 179 (615) T ss_dssp HHHHHHHHHHHTTTT----GGGC-------------CCEEEEECCSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCTTT T ss_pred HHHHHHHHHHHHhcC----CccCCCccccccCCCCCCCeEEEEcCCChHHHHHHHHHHcccCCCeEeccccCcccCCccc Confidence 655544444443211 0000000000011111135678999988877778889999999999999887777766557 Q NP_000836.2 189 YDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKR 268 (908) Q Consensus 189 ~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~ 268 (908) +++++++.|++..++.++++++++++|++|++|+.++.++....+.+++.+++. ++++.....+....+..+....+++ T Consensus 180 ~~~~~r~~p~~~~~~~al~~~l~~~~w~~v~iv~~~~~~g~~~~~~l~~~~~~~-gi~i~~~~~~~~~~~~~~~~~~~~~ 258 (615) T 5K5S_B 180 FKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEER-DICIDFSELISQYSDEEEIQHVVEV 258 (615) T ss_dssp CTTEEESSCCTHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHT-TCEEEEEEEECTTCCHHHHHHHHHH T ss_pred CCCccccCCChHHHHHHHHHHHHHcCCcEEEEEEEcCccchHHHHHHHHHHHHC-CcEEEEEEeecCCCCHHHHHHHHHH Confidence 899999999999999999999999999999999988788888888888888775 4676543333211122345556666 Q NP_000836.2 269 LLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPV-YQQEEIAEGAVTILPKRASIDGFDRYFRS 347 (908) Q Consensus 269 l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~-~~~~~~~~g~~~~~~~~~~~~~~~~~~~~ 347 (908) ++. .++++|++.+....+..+++++.+.|+.+ ..|+..+.|....... ........|.+.+.......++|..|+.. T Consensus 259 l~~-~~~~vvi~~~~~~~~~~~l~~~~~~~~~~-~~~i~~~~~~~~~~~~~~~~~~~~~g~l~~~~~~~~~~~f~~f~~~ 336 (615) T 5K5S_B 259 IQN-STAKVIVVFSSGPDLEPLIKEIVRRNITG-KIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKK 336 (615) T ss_dssp HHT-CCCCEEEEECCHHHHHHHHHHHHHTTCCC-CEEEECTTTTTCTTTCCGGGHHHHTTCEEEEECCBCCTTHHHHHHT T ss_pred HHh-CCCeEEEEeCCchhHHHHHHHHHHcCCCC-CEEEEehhHhcchhccCccccceeceEEEEEeecccCccHHHHHHH Confidence 653 57899888877777888888888888753 5788776664432100 00112334555555444455566666544 Q NP_000836.2 348 RTLANNRRNVWFAEFWEENFGCKLGSHGKR----------------------NSHIKKCTGLERIARD----SSYEQEGK 401 (908) Q Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------------------~~~~~~c~~~~~~~~~----~~~~~~~~ 401 (908) ..+.....+.++.++|++.+.|........ ..+...|++.+.+... .......+ T Consensus 337 ~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~C~~~~~~~~~~~~~~~~~~~~~ 416 (615) T 5K5S_B 337 VHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSQSSTAFRPLCTGDENINSVETPYIDYTHLRI 416 (615) T ss_dssp CCTTTCSSBTTHHHHHHHHTTCBC-------------------------------CCBCCTTCCSTTSCCTTTCCSCBSH T ss_pred hCcccCCCChHHHHHHHHHhCCcCCCCCCCCCCchhhccCCcccCCcccCCCCCCCCCCCCCCCcccCCCCccccccccc Confidence 332223345567777777666542210000 0011123322211000 00112245 Q NP_000836.2 402 VQFVIDAVYSMAYALHNMHKDLCPGY---IGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQI 478 (908) Q Consensus 402 ~~~~yDAv~~la~Al~~~~~~~~~~~---~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~ 478 (908) +.++||||+++|+||+++..+.+... ...|.......++.+.+.|++.+|.|.+|+.|.||++|++...|.|++++. T Consensus 417 ~~~~ydAV~~~A~aL~~~~~~~~~~~~~~~~~c~~~~~~~~~~l~~~l~~~~f~g~~gg~v~fd~~G~~~~~y~I~~~~~ 496 (615) T 5K5S_B 417 SYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLQFTNNMGEQVTFDECGDLVGNYSIINWHL 496 (615) T ss_dssp HHHHHHHHHHHHHHHHHHHTCCTTSCCBTTTBCCCTTSCCHHHHHHHHHTCEEECTTSCEEECCTTSCCCCCEEEEEEEE T ss_pred hhHHHHHHHHHHHHHHHHHhcCCCCCCCCCCCcccccccChHHHHHHHhcCeeeCCCCCEEEECCCCCCCceEEEEEEEe Confidence 67899999999999999976543210 122221112234457788888899987644899999999988999999874 Q NP_000836.2 479 TN--KSTEYKVIGHWTNQL------HLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQV- 548 (908) Q Consensus 479 ~~--~~~~~~~Vg~~~~~~------~~~~~~i~w~~~~~~~p~s~Cs~~c~~G~~k~~~~~-~~Cc~~c~~C~~~~~~~- 548 (908) .+ +...++.||.|+... .++...+.|.++...+|.++|+.+|++|+++...++ +.|||+|.+|+++++++ T Consensus 497 ~~~~~~~~~~~Vg~~~~~~~~~~~l~~~~~~i~W~~~~~~~P~s~Cs~~C~~G~~~~~~~~~~~CC~~C~~C~~~~~s~~ 576 (615) T 5K5S_B 497 SPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDE 576 (615) T ss_dssp CTTTCSEEEEEEEEECSSSCTTSSEEECGGGCCBTTTBCSCCCCCSSCCCCTTEEEEECSSSCTTCEEEEECCTTEECCS T ss_pred CCCCCCEEEEEEEEEEeecCCCCeEEEehhheecCCCCCCCCeeeecCCCCcCceecccCCCCcccceeeeCCCCcEECC Confidence 31 123588999998532 123335789864456699999999999999877666 68999999999999997 Q NP_000836.2 549 -DELSCELCPLDQRPNMNRTGCQLIPIIKLEWH 580 (908) Q Consensus 549 -~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s 580 (908) +.++|.+||.++|||++++.|.+++..|+.|. T Consensus 577 ~~~~~C~~Cp~~~~~n~~~t~C~~~~~~~l~~~ 609 (615) T 5K5S_B 577 TDASACNKCPDDFWSNENHTSCIAKEIEFLSDY 609 (615) T ss_dssp TTCSSCEECCTTEEECTTSSSEEETC------- T ss_pred CCcccccCCCCCceecCCCCcEEecEEEeeccC Confidence 57999999999999999999999988888776 No 14 >5KZQ_A Metabotropic glutamate receptor 2; mGluR2, antagonist, antidepressent, SIGNALING PROTEIN; HET: NAG, 6YS; 2.8A {Homo sapiens} Probab=100.00 E-value=1.7e-42 Score=398.18 Aligned_cols=529 Identities=44% Similarity=0.837 Sum_probs=347.9 Template_Neff=11.000 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) .....+++++||+++|.+........|+......+.....|+++|++++|+++++++|+++++++.|++++...+.+.+. T Consensus 24 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~Ai~~iN~~~~~l~~~~l~~~~~D~~~~~~~a~~~~~ 103 (570) T 5KZQ_A 24 KVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQAL 103 (570) T ss_pred cceEecCCEEEEEeeehhccCCCccccccccCCccHHHHHHHHHHHHHHhcCCCCCCCCeeEEEEEeCCCCHHHHHHHHH Confidence 34677889999999999832211224443222345678899999999999988888999999999999877554444444 Q NP_000836.2 118 TFVQALIEKD--ASDVKCANGDPPIFTK-PDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSR 194 (908) Q Consensus 118 ~~~~~l~~~~--~~~~~~~~~~~~~~~~-~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~ 194 (908) +++....... .....|...++.+... .++++++||+.++..+..++.++..+++|+|++.+.++.++++..++++++ T Consensus 104 ~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~viG~~~s~~~~~~a~~~~~~~ip~is~~~~~~~ls~~~~~~~~~r 183 (570) T 5KZQ_A 104 DFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFAR 183 (570) T ss_pred HHHhcccCCCCCCCceecCCCCcccCCCCCCCceEEECCCChHHHHHHHHHhhhhCCCeeecCCCChhhCCcccCCccee Confidence 4432100000 0000000000000000 136889999988877778888999999999999887777766556899999 Q NP_000836.2 195 VVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 195 ~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) +.|++..+++++++++++++|++|++|++++.++....+.+++.+++. ++++.....++......++...+++++...+ T Consensus 184 ~~p~~~~~~~al~~~l~~~~w~~v~il~~~~~~g~~~~~~~~~~~~~~-~i~i~~~~~~~~~~~~~~~~~~~~~l~~~~~ 262 (570) T 5KZQ_A 184 TVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARAR-NICVATSEKVGRAMSRAAFEGVVRALLQKPS 262 (570) T ss_pred cCCChHHHHHHHHHHHHHhCCcEEEEEEecChhhHHHHHHHHHHHHHc-CcEEEEEEEcCCCCCCcccHHHHHHHHHhCC Confidence 999999999999999999999999999988788888888888887775 4666543333211122345555666642247 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNR 354 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~ 354 (908) +++|++......+..+++++++.|+ ++.|++.+.|...............|.+.+.......++|..|+....+...+ T Consensus 263 ~~viv~~~~~~~~~~~l~~~~~~g~--~~~~i~~~~~~~~~~~~~~~~~~~~g~l~~~~~~~~~~~f~~~~~~~~~~~~~ 340 (570) T 5KZQ_A 263 ARVAVLFTRSEDARELLAASQRLNA--SFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNS 340 (570) T ss_pred cEEEEEECCHHHHHHHHHHHHHhCC--CeEEEEeCcccCChhHHhcchhHhceEEEEecCCCCCCcHHHHHHhcCCCCCC Confidence 8888887776677888888888776 46788776554322110001123344444433333333444443322222223 Q NP_000836.2 355 RNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM 434 (908) Q Consensus 355 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~ 434 (908) .+.++.++|++.+.|.... ..|+.. ..... ......++.++||||+++++|++++....+......|... T Consensus 341 ~~~~~~~~~~~~~~c~~~~--------~~c~~~-~~~~~-~~~~~~~~~~~ydAv~~~a~al~~~~~~~~~~~~~~c~~~ 410 (570) T 5KZQ_A 341 RNPWFREFWEQRFRCSFRQ--------RDCAAH-SLRAV-PFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAM 410 (570) T ss_pred CCHHHHHHHHHHcCCCCCC--------CCCCCC-CcccC-CCCCCcchHHHHHHHHHHHHHHHHHHhccCCCCCCCcccc Confidence 4556777777666553210 011110 00000 0112345678999999999999998764332211223221 Q NP_000836.2 435 STIDGKEL-LGYIRAVNFNG------SAGTPVTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQLHLKVEDMQWAH 506 (908) Q Consensus 435 ~~~~~~~l-~~~l~~~~f~G------~~G~~v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~~~~~~~i~w~~ 506 (908) ...++.++ .+.+++..|.+ .+| .+.||++|++...|.|++++..+ +...++.||.|+....++...+.|++ T Consensus 411 ~~~~~~~l~~~~l~~~~f~~~~~~~~~~g-~v~fd~~G~~~~~y~i~~~~~~~~~~~~~~~vg~~~~~~~~~~~~i~W~~ 489 (570) T 5KZQ_A 411 RPVNGRRLYKDFVLNVKFDAPFRPADTHN-EVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWAS 489 (570) T ss_pred CcCChhHHHHhhhhceeecCCCCCCCCCC-EEEeCCCCCCCccEEEEEEEEcCCCCeeEEEEEEECCCCccccccccCCC Confidence 11234443 35577777763 566 89999999998889998887432 12368899999865444434678976 Q NP_000836.2 507 RE-HTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWH 580 (908) Q Consensus 507 ~~-~~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s 580 (908) +. .+.|.++|++.|++|+++...+++.|||+|.+|++|+++++.++|.+||.++|||++++.|.+++..|+.+. T Consensus 490 ~~~~~~~~s~C~~~C~~g~~~~~~~~~~CC~~C~~C~~g~~~~~~~~C~~Cp~~~~~n~~~~~C~~~~~~~l~~~ 564 (570) T 5KZQ_A 490 PSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIREG 564 (570) T ss_pred CCCCCCCceeecCCCCCCceeCCCCCCccccccccCCCCeeecCccccccCCCccccCCCCCCeEecceehhccC Confidence 42 345889999999999998766567899999999999999988999999999999999999999888887664 No 15 >5K5T_A Extracellular calcium-sensing receptor; Venus Flytrap module, cysteine rich; HET: NAG, SO4; 3.1A {Homo sapiens} Probab=100.00 E-value=2.4e-42 Score=400.86 Aligned_cols=534 Identities=32% Similarity=0.559 Sum_probs=355.1 Template_Neff=11.000 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGER----------GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSR 108 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~----------~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~ 108 (908) ....+++++||+++|.++.... ...|+.. ...+.....|+++|++++|+++++++|+++++.+.|++++ T Consensus 25 ~~~~~~~i~Ig~l~p~~~~~~~~~~~~~~~~~~~~c~~~-~~~~~~~~~a~~~Av~~iN~~~~llp~~~l~~~~~D~~~~ 103 (615) T 5K5T_A 25 RAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRY-NFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNT 103 (615) T ss_dssp CEEECCSEEEEEEECSBSCBCCCCCCCSSCCCCCCBCSB-CHHHHHHHHHHHHHHHHHHHCSSSSTTCCEEEEEEECTTC T ss_pred ceEecCCEEEEeeeeeeecccCCCCCcccCCCcccceee-ccccHHHHHHHHHHHHHHhcCCCCCCCCceeEEEEcCCCC Confidence 4567789999999999864321 1234321 1245678899999999999998888999999999999887 Q NP_000836.2 109 DTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTR 188 (908) Q Consensus 109 ~~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~ 188 (908) ...+.+.+.+++... .....+....+.+.....++.++||+.++..+..++.++..+++|+|++.+.++.++++.. T Consensus 104 ~~~a~~~~~~l~~~~----~~~~~~~~~~~~~~~~~~~v~~viG~~~s~~~~~~a~~~~~~~ip~is~~~~~~~l~~~~~ 179 (615) T 5K5T_A 104 VSKALEATLSFVAQN----KIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQ 179 (615) T ss_dssp HHHHHHHHHHHHCCC----CCHHHSGGGGCC-----CCEEEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTT T ss_pred HHHHHHHHHHHHhcC----CccCCCccccccCCCCCCCeEEEEcCCChHHHHHHHHHhcccCCCeEeccccCcccCCccc Confidence 655444444443210 0000000000011111135678999988877778888999999999999887777766556 Q NP_000836.2 189 YDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKR 268 (908) Q Consensus 189 ~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~ 268 (908) +++++++.|++..++.++++++++++|++|++++.+++++....+.|++.+++. ++++.....+....+..++...+++ T Consensus 180 ~~~~~~~~p~~~~~~~al~~~l~~~~w~~v~vl~~~~~~g~~~~~~~~~~~~~~-gi~v~~~~~~~~~~~~~~~~~~~~~ 258 (615) T 5K5T_A 180 FKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEER-DICIDFSELISQYSDEEEIQHVVEV 258 (615) T ss_dssp CTTEEESSCCTTHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHT-TCEEEEEEEECTTCCHHHHHHHHHH T ss_pred CCcccccCCChHHHHHHHHHHHHHcCCcEEEEEEecCcccchHHHHHHHHHHHC-CcEEEEEEeecCCCCHHHHHHHHHH Confidence 899999999999999999999999999999999988888888888888888775 4776544333211122345556666 Q NP_000836.2 269 LLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPV-YQQEEIAEGAVTILPKRASIDGFDRYFRS 347 (908) Q Consensus 269 l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~-~~~~~~~~g~~~~~~~~~~~~~~~~~~~~ 347 (908) ++. .++++|++......+..+++++.+.++.+ ..|+..+.|....... ........|.+.+.......++|..|+.. T Consensus 259 i~~-~~~~viv~~~~~~~~~~~l~~~~~~~~~~-~~~i~~~~~~~~~~~~~~~~~~~~~g~l~~~~~~~~~~~f~~f~~~ 336 (615) T 5K5T_A 259 IQN-STAKVIVVFSSGPDLEPLIKEIVRRNITG-KIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKK 336 (615) T ss_dssp HHH-CCCCEEEEECCHHHHHHHHHHHHHHTCCC-CEEEECHHHHTCTTTCCGGGHHHHTTCEEEEECCBCCTTHHHHHHT T ss_pred HHh-CCCeEEEEeCCchhHHHHHHHHHHcCCCC-CEEEEehhHhcchhccCccccceeceEEEEEeccccCccHHHHHHH Confidence 663 57899988877777888888888888753 5788777665432110 00112344555555444445566666544 Q NP_000836.2 348 RTLANNRRNVWFAEFWEENFGCKLGSHGKR----------------------NSHIKKCTGLERIARD----SSYEQEGK 401 (908) Q Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------------------~~~~~~c~~~~~~~~~----~~~~~~~~ 401 (908) ..+.....+.++.++|+..+.|........ ..+...|++.+.+... .......+ T Consensus 337 l~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~C~~~~~~~~~~~~~~~~~~~~~ 416 (615) T 5K5T_A 337 VHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSQSSTAFRPLCTGDENINSVETPYIDYTHLRI 416 (615) T ss_dssp CCTTTCSSBTHHHHHHHHHHTSEECSSCCSCCCSCTTGGGGGSTTCCSSSGGGTCCCEECSCCCTTTSCCTTTCCSCBSH T ss_pred hCcccCCCChHHHHHHHHHhCCcCCCCCCCCCCchhhccCCcccCCcccCCCCCCCCCCCCCCCcccCCCCccccccccc Confidence 332223344566777777666542210000 0011123322211100 00112345 Q NP_000836.2 402 VQFVIDAVYSMAYALHNMHKDLCPG---YIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQI 478 (908) Q Consensus 402 ~~~~yDAv~~la~Al~~~~~~~~~~---~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~ 478 (908) +.++||||+++|+||+++..+.+.. ....|.......++.+.+.|++.+|.|.+|+.|.||++|++...|.|++++. T Consensus 417 ~~~~ydAV~~~A~aL~~~~~~~~~~~~~~~~~c~~~~~~~~~~l~~~l~~~~f~g~~G~~v~fd~~Gd~~~~y~I~~~~~ 496 (615) T 5K5T_A 417 SYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHL 496 (615) T ss_dssp HHHHHHHHHHHHHHHHHHHHCCTTSBTBTTBBCCCSTTCCHHHHHHHHHSCEEECTTSCEEEBCSSSBBCCEEEEEEEEE T ss_pred hhHHHHHHHHHHHHHHHHHhcCCCCCCCCCCCCccccccCHHHHHHHHhhCeEECCCCCEEEeCCCCCCCceEEEEEEEe Confidence 6789999999999999987654321 0122222112334557788888899988776799999999988999999874 Q NP_000836.2 479 TN--KSTEYKVIGHWTNQL------HLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQV- 548 (908) Q Consensus 479 ~~--~~~~~~~Vg~~~~~~------~~~~~~i~w~~~~~~~p~s~Cs~~c~~G~~k~~~~~-~~Cc~~c~~C~~~~~~~- 548 (908) .. +...++.||.|+... .++...+.|.++...+|.++|+.+|++|+++...++ +.|||+|.+|+++++++ T Consensus 497 ~~~~~~~~~~~Vg~~~~~~~~~~~l~~~~~~i~W~~~~~~~P~s~Cs~~C~~G~~~~~~~~~~~Cc~~C~~C~~~~~s~~ 576 (615) T 5K5T_A 497 SPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDE 576 (615) T ss_dssp CTTTCSEEEEEEEEEESSSCTTSSEEECGGGCCBTTTBCSCCCCCSSCCCCTTEEEEECSSSCTTCEEEEECCTTEECCS T ss_pred CCCCCCEEEEEEEEEEeecCCCCeEEEeccceecCCCCCCCCeeeecCCCCcCceecccCCCCcccceeeeCCCCcEECC Confidence 31 123588999998542 123335789764446699999999999999877666 68999999999999997 Q NP_000836.2 549 -DELSCELCPLDQRPNMNRTGCQLIPIIKLEWH 580 (908) Q Consensus 549 -~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s 580 (908) +.++|.+||.++|||++++.|.+++..|+.|+ T Consensus 577 ~~~~~C~~Cp~~~~~n~~~t~C~~~~~~~l~~~ 609 (615) T 5K5T_A 577 TDASACNKCPDDFWSNENHTSCIAKEIEFLSDY 609 (615) T ss_dssp SSCSSCEECCTTEEECTTSSSEEECCC------ T ss_pred CCcccccCCCCCceecCCCCcEEecEEEeecCC Confidence 57999999999999999999999988888776 No 16 >6FFH_A Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate; 7TM, RECEPTOR, GPCR, MEMBRANE-PROTEIN, SIGNALING; HET: D7W, OLC, YCM, MES, OLA; 2.65A {Homo sapiens} Probab=100.00 E-value=9.6e-38 Score=308.98 Aligned_cols=266 Identities=48% Similarity=0.851 Sum_probs=223.2 Template_Neff=4.100 Q NP_000836.2 573 PIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRR 652 (908) Q Consensus 573 ~~~~~~~s~~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~~~~C~~~~ 652 (908) +.++..+++++.+++.+++++|++++++++++++++|+++++|.+++.+++++|+|+.++|+++++++..|+...|.+|. T Consensus 4 PveyLs~S~~~~i~llaLSaIGILitLiiLIIfI~~RsTPvIk~ssp~L~~~iLLG~~l~~~~~~~~~~~p~~~~C~lR~ 83 (444) T 6FFH_A 4 PVQYLRWGDPAPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFXLIAKPKQIYCYLQR 83 (444) T ss_dssp HHHHHHTTCCHHHHHHHHHHHHHHHHHHHHHHHHHTTTSHHHHHSCHHHHHHHHHHHHHHHHTHHHHBSCSCHHHHHHHH T ss_pred cceeccCCCHHHHHHHHHHHHHHHHHHHHHHHHHHcCCCchhhcCCHHHHHHHHHHHHHHHHHHHHhccCCchhHHHHHH Confidence 45677889999999999999999999999999999999999999999999999999999999999999999999999999 Q NP_000836.2 653 VFLGLGMCFSYAALLTKTNRIHRIFEQGKKSV---------TAP------------------------------------ 687 (908) Q Consensus 653 ~~~~~gf~l~~~~l~~K~~ri~~if~~~~~~~---------~~~------------------------------------ 687 (908) |++++||+++||++++|+||++++|..++++. .++ T Consensus 84 ~~l~lgfsl~~~~l~vKt~RI~~if~~~~~~~~~~~~~~~~~~~~~i~d~~l~~~v~~~~l~~~~~~~~~~~~~~d~~~~ 163 (444) T 6FFH_A 84 IGIGLSPAMSYSALVTKTYRAARILAMSKKNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIG 163 (444) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHTCCEEEEEECTTSCEEEETTEEEESSSCHHHHHHHHHHHHS T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHhccccChhhhhhcccccceeeecCcchhhhhhhhHHhcCCcccchhhhhhhhhcc Confidence 99999999999999999999999998664320 000 Q NP_000836.2 688 -------------------------------------------------------------------------------- 687 (908) Q Consensus 688 -------------------------------------------------------------------------------- 687 (908) T Consensus 164 ~~~~~~~~~~~~~~~~~~~~d~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 243 (444) T 6FFH_A 164 RNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAV 243 (444) T ss_dssp SCCTTBCCHHHHHHHHHHHHHHHHHHHHTCTTTHHHHHHSCHHHHHHHHHHHHHHCHHHHTTCHHHHHHHHTTCHHHHHH T ss_pred cCCCCccchhHHHHHhcCchhHHHHHhHhccCCCccccchhHHHHHHHHHhhhccCcccccccchhHHHHHHhchhHHHH Confidence Q NP_000836.2 688 -------------------------------------KFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRT 730 (908) Q Consensus 688 -------------------------------------~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~ 730 (908) ++.+.+.++.++++++.+|+++++.|...+|+........ T Consensus 244 ~~~~~~w~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~iq~~i~~~~~~~~pp~~~~~~~~--- 320 (444) T 6FFH_A 244 NLAKSRWYNQTPNRAKRVITTFRTGTWDAYKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPS--- 320 (444) T ss_dssp HHTTSHHHHHSHHHHHHHHHHHHHSSSTTSCC--------CHHHHHHHHHHHHHHHHHHHHHHHHHSCCCBSSSCC---- T ss_pred hhhhcccccCCCCccceeeeeeecCCccchhhccCCcccCCHHHHHHHHHHHHHHHHHHHHHHHhcCCCCCccCCcc--- Confidence 0112233455566677899999999999998876543211 Q NP_000836.2 731 LDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEK 810 (908) Q Consensus 731 ~~~~~~~~~~~C~~~~~~~~~~~~~~~~ll~~~~~la~~~R~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~ 810 (908) .......|...+.++++.++|+++|+++|+++|+++|++|++|||+|+|++++|+.+++|+++.|+++..... T Consensus 321 ----~~~~~~~C~~~~~~~~~~l~y~~iLll~~~~~A~~tR~vp~~fnEak~I~~~~y~~~ii~~~~~p~~~~~~~~--- 393 (444) T 6FFH_A 321 ----IREVYLICNTTNLGVVAPLGYNGLLILACTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK--- 393 (444) T ss_dssp ------CCBCCBCCCHHHHHHHHHHHHHHHHHHHHHHHHTTTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCSCH--- T ss_pred ----cceEEEeecCCChHHHHHHHHHHHHHHHHHHHHHHhcCCchhhhHHHHHHHHHHHHHHHHHHHHHHHHcCCcH--- Confidence 2345679998777778899999999999999999999999999999999999999999999999998876533 Q NP_000836.2 811 MYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKR 852 (908) Q Consensus 811 ~~~~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~ 852 (908) +.+.++++++++++.++++|+||+|.++++||++.+.. T Consensus 394 ----~~~~~~~i~l~~t~~l~~iF~PK~~~I~~~p~~n~~~~ 431 (444) T 6FFH_A 394 ----IITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSA 431 (444) T ss_dssp ----HHHHHHHHHHHHHHHHHHHTHHHHHHHHHCTTTC---- T ss_pred ----HHHHHHHHHHHHHHHHHHHHHHHHHHHHcCcccchHHH Confidence 23677899999999999999999999999999887653 No 17 >6FFI_A Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate; 7TM, RECEPTOR, GPCR, MEMBRANE-PROTEIN, SIGNALING; HET: YCM, MES, OLA, D8B; 2.2A {Homo sapiens} Probab=100.00 E-value=9.6e-38 Score=308.98 Aligned_cols=266 Identities=48% Similarity=0.851 Sum_probs=222.1 Template_Neff=4.100 Q NP_000836.2 573 PIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRR 652 (908) Q Consensus 573 ~~~~~~~s~~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~~~~C~~~~ 652 (908) +.++..+++++.+++.+++++|++++++++++++++|+++++|.+++.+++++|+|+.++|+++++++..|+...|.+|. T Consensus 4 PveyLs~S~~~~i~llaLSaIGILitLiiLIIfI~~RsTPvIk~ssp~L~~~iLLG~~l~~~~~~~~~~~p~~~~C~lR~ 83 (444) T 6FFI_A 4 PVQYLRWGDPAPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFXLIAKPKQIYCYLQR 83 (444) T ss_dssp HHHHHHTTCCHHHHHHHHHHHHHHHHHHHHHHHHHGGGSHHHHSSCHHHHHHHHHHHHHHHHTHHHHBCCSCHHHHHHHH T ss_pred cceeccCCCHHHHHHHHHHHHHHHHHHHHHHHHHHcCCCchhhcCCHHHHHHHHHHHHHHHHHHHHhccCCchhHHHHHH Confidence 45677889999999999999999999999999999999999999999999999999999999999999999999999999 Q NP_000836.2 653 VFLGLGMCFSYAALLTKTNRIHRIFEQGKKSV---------TAP------------------------------------ 687 (908) Q Consensus 653 ~~~~~gf~l~~~~l~~K~~ri~~if~~~~~~~---------~~~------------------------------------ 687 (908) |++++||+++||++++|+||++++|..++++. .++ T Consensus 84 ~~l~lgfsl~~~~l~vKt~RI~~if~~~~~~~~~~~~~~~~~~~~~i~d~~l~~~v~~~~l~~~~~~~~~~~~~~d~~~~ 163 (444) T 6FFI_A 84 IGIGLSPAMSYSALVTKTYRAARILAMSKKNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIG 163 (444) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCEEEEEECTTCCEEEETTEECCCSSCHHHHHHHHHHHHS T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHhccccChhhhhhcccccceeeecCcchhhhhhhhHHhcCCcccchhhhhhhhhcc Confidence 99999999999999999999999998664320 000 Q NP_000836.2 688 -------------------------------------------------------------------------------- 687 (908) Q Consensus 688 -------------------------------------------------------------------------------- 687 (908) T Consensus 164 ~~~~~~~~~~~~~~~~~~~~d~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 243 (444) T 6FFI_A 164 RNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAV 243 (444) T ss_dssp SCCTTBCCHHHHHHHHHHHHHHHHHHHHTCTTTHHHHHHSCHHHHHHHHHHHHHHHHHHHTTCHHHHHHHHTTCHHHHHH T ss_pred cCCCCccchhHHHHHhcCchhHHHHHhHhccCCCccccchhHHHHHHHHHhhhccCcccccccchhHHHHHHhchhHHHH Confidence Q NP_000836.2 688 -------------------------------------KFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRT 730 (908) Q Consensus 688 -------------------------------------~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~ 730 (908) ++.+.+.++.++++++.+|+++++.|...+|+........ T Consensus 244 ~~~~~~w~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~iq~~i~~~~~~~~pp~~~~~~~~--- 320 (444) T 6FFI_A 244 NLAKSRWYNQTPNRAKRVITTFRTGTWDAYKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPS--- 320 (444) T ss_dssp HHTTSHHHHHSHHHHHHHHHHHHHSSSTTSCC--------CHHHHHHHHHHHHHHHHHHHHHHHHHSCCCBC-------- T ss_pred hhhhcccccCCCCccceeeeeeecCCccchhhccCCcccCCHHHHHHHHHHHHHHHHHHHHHHHhcCCCCCccCCcc--- Confidence 0112233455566677899999999999998876543211 Q NP_000836.2 731 LDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEK 810 (908) Q Consensus 731 ~~~~~~~~~~~C~~~~~~~~~~~~~~~~ll~~~~~la~~~R~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~ 810 (908) .......|...+.++++.++|+++|+++|+++|+++|++|++|||+|+|++++|+.+++|+++.|+++..... T Consensus 321 ----~~~~~~~C~~~~~~~~~~l~y~~iLll~~~~~A~~tR~vp~~fnEak~I~~~~y~~~ii~~~~~p~~~~~~~~--- 393 (444) T 6FFI_A 321 ----IREVYLICNTTNLGVVAPLGYNGLLILACTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK--- 393 (444) T ss_dssp ------CCBCCBCCCHHHHHHHHHHHHHHHHHHHHHHHHTTTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCSCH--- T ss_pred ----cceEEEeecCCChHHHHHHHHHHHHHHHHHHHHHHhcCCchhhhHHHHHHHHHHHHHHHHHHHHHHHHcCCcH--- Confidence 2345679998777778899999999999999999999999999999999999999999999999998876533 Q NP_000836.2 811 MYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKR 852 (908) Q Consensus 811 ~~~~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~ 852 (908) +.+.++++++++++.++++|+||+|.++++||++.+.. T Consensus 394 ----~~~~~~~i~l~~t~~l~~iF~PK~~~I~~~p~~n~~~~ 431 (444) T 6FFI_A 394 ----IITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSA 431 (444) T ss_dssp ----HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCTTTC---- T ss_pred ----HHHHHHHHHHHHHHHHHHHHHHHHHHHHcCcccchHHH Confidence 23677899999999999999999999999999887653 No 18 >4OR2_B Chimera of Soluble cytochrome b562; Human metabotropic glutamate receptor 1; HET: PO4, OLC, OLA, CLR, FM9; 2.8A {Escherichia coli, Homo sapiens} Probab=100.00 E-value=1.8e-37 Score=330.24 Aligned_cols=271 Identities=46% Similarity=0.820 Sum_probs=228.1 Template_Neff=8.400 Q NP_000836.2 570 QLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICS 649 (908) Q Consensus 570 ~~~~~~~~~~s~~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~~~~C~ 649 (908) .+.+..+.+++++..+++.+++++|++++++++++++++|+++.+|+++|.++.++++|++++|++++++..+|++..|. T Consensus 108 ~~~p~~~l~~~~~~~i~~~~l~~lgil~~l~~~~~~~~~R~~~vIk~ss~~l~~liL~G~~l~~~s~~~~~~~ps~~~C~ 187 (389) T 4OR2_B 108 YLIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCY 187 (389) T ss_dssp GTSCCBCCCTTSHHHHHHHHHHHHHHHHHHHHHHHHHHTSSSHHHHTSCHHHHHHHHHHHHHHHHHHHHHHSCCCHHHHH T ss_pred ccCcccccCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHcCCChhhhcCCHHHHHHHHHHHHHHHHHHHHhcCCCchhcHh Confidence 33355677888999999999999999999988999999999999999999999999999999999999999899999999 Q NP_000836.2 650 FRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSV--TAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGE 727 (908) Q Consensus 650 ~~~~~~~~gf~l~~~~l~~K~~ri~~if~~~~~~~--~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~ 727 (908) +|.|++++||+++||++++|+||++++|++++++. +.++..+++.++..++++++++++++++|+..+|+.+...... T Consensus 188 ~r~~~~~lgf~l~~g~l~~Kt~Ri~~iF~~~~~~~~~~~~~~~~~~~~~~~~~~l~~i~~iil~~w~~~~p~~~~~~~~~ 267 (389) T 4OR2_B 188 LQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPS 267 (389) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC-----CCCCCSSCSHHHHHHHHHHHHHHHHHHHHHHHHHSCCCEEEECCS T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCCCcCCCcccCCHHHHHHHHHHHHHHHHHHHHHHHhcCCCCCeecCCC Confidence 99999999999999999999999999998765421 1234566777777788888999999999999999887543211 Q NP_000836.2 728 QRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQS 807 (908) Q Consensus 728 ~~~~~~~~~~~~~~C~~~~~~~~~~~~~~~~ll~~~~~la~~~R~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~ 807 (908) .......|++.+.++.+.++|+++|++++++|||++|++|++|||+|+|++++|+++++|+++.|+++..+. T Consensus 268 -------~~~~~~~C~~~~~~~~~~~~y~~lLl~~~~~LA~~tR~~~~~~nEsk~i~~~iy~~~~~~~i~~p~~~~~~~- 339 (389) T 4OR2_B 268 -------IKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNY- 339 (389) T ss_dssp -------SSCCEEEECCCSHHHHHHHHHHHHHHHHHHHHHHHTTTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSC- T ss_pred -------CceEEEecCCCcHHHHHHHHHHHHHHHHHHHHHHHhcCCCcccCHHHHHHHHHHHHHHHHHHHHHHHhCCCH- Confidence 123456899876667788999999999999999999999999999999999999999999999999875432 Q NP_000836.2 808 AEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKR 854 (908) Q Consensus 808 ~~~~~~~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~ 854 (908) .+.+.+++++++++++++++|+||++.++++|+++.+++.+ T Consensus 340 ------~~~~~~~~il~~~~~~l~~lF~PK~~~i~~~~~~~~~~~~~ 380 (389) T 4OR2_B 340 ------KIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFT 380 (389) T ss_dssp ------HHHHHHHHHHHHHHHHCCCCCHHHHHHHHTCHHHHC----- T ss_pred ------HHHHHHHHHHHHHHHHHHHHHccceeEEeeCcccchhhhhh Confidence 23467788899999999999999999999999998876544 No 19 >6BT5_B Metabotropic glutamate receptor 8; mGluR8, GRM8, L-AP4, GENE ID:; HET: NAG, E7P; 2.92A {Homo sapiens} Probab=99.87 E-value=2.3e-27 Score=265.12 Aligned_cols=468 Identities=100% Similarity=1.505 Sum_probs=271.7 Template_Neff=11.300 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...+++++||+++|+++.......|+......+.....|+++|++++|+++++++|.++++.+.|++.++..+.+.+... T Consensus 4 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~~~~~a~~~iN~~~~~~~~~~l~~~~~d~~~~~~~~~~~~~~~ 83 (479) T 6BT5_B 4 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 83 (479) T ss_dssp EEECCSEEEEEEECCEEECSSSCSEEEECCCCCCCHHHHHHHHHHHHHHCSSTTTTCCEEEEEEECTTCHHHHHHHHGGG T ss_pred eeeCCCEEEEEEEeccccCCCCCCCCcccccccHHHHHHHHHHHHHHhcCCCcCCCCeEeeEEecCCCCHHHHHHHHHHH Confidence 35567899999999987543223454432235677889999999999998887778899999999877643323333444 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++++.+...+..|...........++++++||+.++..+..++.++...++|+|++.+..+.+.+...+++++++.++. T Consensus 84 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~~~~~~ 163 (479) T 6BT5_B 84 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 163 (479) T ss_dssp CC------------------------CEEEEECCSSHHHHHHHHHHHTTTTCCEEESSCCCGGGGCTTTCTTEEESSCCH T ss_pred HHHHHhccccccccCCCCCCccCCCCceEEEEcCCCchHHHHHHHHHHHhCCCEEecCCCCcccCCcccccceeecCCCh Confidence 44433210000000000000000013788999998887777888999999999999887666554433578899999999 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) ...+.++++++.+++|+++++++.++.++....+.+++.+++.+++++.....+.......++...++++++..++++|+ T Consensus 164 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~~~v~~~~~~~~~~~~~~~~~~~~~i~~~~~~~~iv 243 (479) T 6BT5_B 164 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVSIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 243 (479) T ss_dssp HHHHHHHHHHHHHHTCCEEEEEEESSHHHHHHHHHHHHHHHHCSSCEEEEEEEECSSCCTTHHHHHHHHHTTSTTCCEEE T ss_pred HHHHHHHHHHHHHhCCCEEEEEEEcCcchHHHHHHHHHHHHHhCCeEEEEEEecCCCCCcchHHHHHHHHHhCCCCcEEE Confidence 88999999999888999999999777778777888887776642244443222221112234556666665224788888 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) +......+..+++++++.|+..++.|++.+.|...............+.+.+.+.......+..++........+...++ T Consensus 244 ~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~f 323 (479) T 6BT5_B 244 MFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 323 (479) T ss_dssp EECCHHHHHHHHHHHHHTTCTTTCEEEECTTTTTCSTTTTTCTTTTTTCEEEEESCCCCHHHHHHHHTCCTTTCCSCTTH T ss_pred EeCCHHHHHHHHHHHHHhCCCCCeEEEEeccccCCCcchhcccchhceeEEEeccccCCCcHHHHHHcCCcccCCCCHHH Confidence 87777778889999998887534567766544322110000111223333222211111122222111100111223445 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDG 439 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~ 439 (908) .++|++.+++..............|+..+............++..+|||+++++.|++++....+......|......++ T Consensus 324 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDav~~l~~al~~~~~~~~~~~~~~c~~~~~~~~ 403 (479) T 6BT5_B 324 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDG 403 (479) T ss_dssp HHHHHHHHTCCC-----------CCCSCCCBTTTBCCCCCTTHHHHHHHHHHHHHHHHHHHHHHSSSCSSCCGGGSSCCH T ss_pred HHHHHHHhCCcccCCCccccccccccccchhcCCccccccccHHHHHHHHHHHHHHHHHHHHhhCCCCCCCChhhccCCH Confidence 56666555432110000000011222211100000011234677899999999999998865432211122322122345 Q NP_000836.2 440 KELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHR 507 (908) Q Consensus 440 ~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~~ 507 (908) ..+.+.|++..|.|.+|.+++||++|++...+.+++++..+....++.||.|+....+....+.|+++ T Consensus 404 ~~l~~~l~~~~f~G~tG~~~~f~~~g~~~~~~~i~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~~~ 471 (479) T 6BT5_B 404 KELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHR 471 (479) T ss_dssp HHHHHHHHTCEEECTTSSEEECCSSSCCCCEEEEEEEEEETTEEEEEEEEEEESSEEECGGGCCC--- T ss_pred HHHHHHHHhCceecCCCCeeEeCCCCCCCCcEEEEEEEEeCCceeEEEEEEEecceeecHHheeeccc Confidence 56778888889999877469999999988888888887432123578899999765554456788754 No 20 >6BSZ_A Metabotropic glutamate receptor 8; mGluR8, GRM8, glutamate, GENE ID:; HET: GGL, NAG, SO4; 2.65A {Homo sapiens} Probab=99.86 E-value=3.3e-27 Score=263.84 Aligned_cols=468 Identities=100% Similarity=1.503 Sum_probs=273.7 Template_Neff=11.300 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...+++++||+++|.++.......|+......+.....|+++|++++|++++++++.++++.+.|++.+...+.+.+.+. T Consensus 4 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~~~~~a~~~iN~~~~~~~~~~l~~~~~d~~~~~~~~~~~~~~~ 83 (479) T 6BSZ_A 4 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 83 (479) T ss_dssp EEECCSEEEEEEECCEEECSTTCSEEEECCCCCCCHHHHHHHHHHHHHHCSSTTTTCCEEEEEEECTTCHHHHHHHHGGG T ss_pred eeeCCCEEEEEeeeceecCCCCCCCCcccccccHHHHHHHHHHHHHHhcCCCcCCCceEeeEEecCCCCHHHHHHHHHHH Confidence 34567999999999987543223455433335677889999999999998877778899999999877653323333334 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++++.+......|...........++++++||+.++.....++.++...++|+|++.+..+.+.+...+++++++.++. T Consensus 84 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~~~~~~ 163 (479) T 6BSZ_A 84 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 163 (479) T ss_dssp CCC-----------------------CEEEEECCSSHHHHHHHHHHHTTTTCCEEESSCCCGGGGCTTTCTTEEESSCCH T ss_pred HHHHHhccccccccCCCCCCccCCCCceEEEEcCCCchHHHHHHHHHHHhCCCeEecCCCCccccCcccccceeecCCCh Confidence 44333210000000000000000013788999998887777888899999999999887666554434578899999999 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) ...+.++++++++++|+++++++.++.++....+.+.+.+++.+++++.....+....+..++...++++++..++++|+ T Consensus 164 ~~~~~a~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~~~~~v~~~~~~~~~~~~~~~~~~~~~i~~~~~~~~iv 243 (479) T 6BSZ_A 164 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVSIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 243 (479) T ss_dssp HHHHHHHHHHHHHHTCCEEEEEEESSHHHHHHHHHHHHHHHHSSSCEEEEEEEECSSCCTTHHHHHHHHHTTSTTCCEEE T ss_pred HHHHHHHHHHHHHhCCCEEEEEEecCcccHHHHHHHHHHHHHhCCeEEEEEEecCCCCCcchHHHHHHHHHhCCCCcEEE Confidence 98999999999889999999999877778878888887776542244443222211112234556666665224788888 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) +......+..+++++.+.++.+++.|+..+.|...............+.+.+.+.......+..++........+...++ T Consensus 244 ~~~~~~~~~~~l~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 323 (479) T 6BSZ_A 244 MFANEDDIRRILEAAKKLQQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 323 (479) T ss_dssp EECCHHHHHHHHHHHHHTTCTTTCEEEECTTTTTCSTTTTTCTTTTTTCEEEEESCCCCHHHHHHHHTCCTTTCCSCTTH T ss_pred EeCCHHHHHHHHHHHHHhccCCCeEEEEeccccCCccchhcccchheeeEEEeccccCCCcHHHHHHcCCcccCCCCHHH Confidence 87776778888999888876534667766544322110000111223333322221111122211111000011223345 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDG 439 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~ 439 (908) .++|++.+++..............|...+............++..+|||+++++.|+++.....+......|......++ T Consensus 324 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDav~~~~~al~~~~~~~~~~~~~~c~~~~~~~~ 403 (479) T 6BSZ_A 324 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDG 403 (479) T ss_dssp HHHHHHHHTCCC-----------CCCSCCCTTTTSCCCCCTTHHHHHHHHHHHHHHHHHHHHHHSSSCSSCCGGGSSCCH T ss_pred HHHHHHHhCCcccCCCCcccccccccCcccccCCccccccccHHHHHHHHHHHHHHHHHHHHhhCCCCCCCCchhccCCH Confidence 56666554432110000000011122111000000011234677899999999999998865432211122322122345 Q NP_000836.2 440 KELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHR 507 (908) Q Consensus 440 ~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~~ 507 (908) ..+.+.|++.+|.|.+|+.+.||++|++...+.+++++..+....+..||.|+....++...+.|+++ T Consensus 404 ~~l~~~l~~~~f~G~tG~~v~fd~~g~~~~~~~i~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~~~ 471 (479) T 6BSZ_A 404 KELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHR 471 (479) T ss_dssp HHHHHHHHHCCEECTTSCEECCCTTSCCCCEEEEEEEEECSSCEEEEEEEEEESSEEECGGGCCCCCC T ss_pred HHHHHHHHhCceecCCCCceEeCCCCCCCCcEEEEEEEEeCCceeeEEEEEEecceeeeHhhceeccc Confidence 56778888889999877469999999988788888887422123578899999765555556888764 No 21 >3KS9_B Metabotropic glutamate receptor 1; Glutamate Receptors, mGluR1, Dimerization, Glutamic; HET: Z99, NAG; 1.9A {Homo sapiens} Probab=99.85 E-value=1.4e-26 Score=259.76 Aligned_cols=465 Identities=41% Similarity=0.750 Sum_probs=274.0 Template_Neff=11.100 Q NP_000836.2 37 AHSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYA 112 (908) Q Consensus 37 ~~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a 112 (908) ......+++++||+++|.++... ....|+......+.....|+++|++++|+++++++|+++++.+.|+++++..+ T Consensus 9 ~~~~~~~~~~~Ig~l~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~a~~~in~~~~~~~~~~i~~~~~d~~~~~~~~ 88 (496) T 3KS9_B 9 RSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVA 88 (496) T ss_dssp CCCEEECCSEEEEEEECSBCCCCGGGGGGTCCCCBCCCCCCHHHHHHHHHHHHHHHCSSSSTTCCEEEEEEECTTCHHHH T ss_pred cceEEecCCEEEEEEEEeccCCCCCCCCCCCCccccccccHHHHHHHHHHHHHHhcCCCCCCCceEeeEEEeCCCCHHHH Confidence 34456778999999999987531 12356543334567788999999999999877777899999999988876544 Q NP_000836.2 113 LEQSLTFVQALIE----KDASDVKCANGDP--PIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN 186 (908) Q Consensus 113 ~~~~~~~~~~l~~----~~~~~~~~~~~~~--~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~ 186 (908) .+.+.+++..... +......|...+. .....+++++++||+.++.....++.++...++|+|++.+..+.+.+. T Consensus 89 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~ 168 (496) T 3KS9_B 89 LEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDK 168 (496) T ss_dssp HHHHHHHHHTTC--------------------------CCEEEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCT T ss_pred HHHHHHHHHHccccccCCCCcccccCCCCCCCCCCCCCCCeEEEEcCCCcHHHHHHHHHHHHhCCCEEEeccCchhcCCc Confidence 4443333321000 0000000000000 000001578899998887777778888999999999988766655443 Q NP_000836.2 187 TRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKII 266 (908) Q Consensus 187 ~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~ 266 (908) ..+++++++.++....+.++++++++++|+++++++.++.++....+.+++.+++. ++++.....+.......++...+ T Consensus 169 ~~~~~~~~~~~~~~~~~~a~~~~l~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~l 247 (496) T 3KS9_B 169 TLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQE-GLSIAHSDKIYSNAGEKSFDRLL 247 (496) T ss_dssp TTCTTEEESSCCTHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHTTT-TCEEEEEEEECTTCCHHHHHHHH T ss_pred cccCcceecCCCHHHHHHHHHHHHHHcCCCEEEEEEeCCcchhHHHHHHHHHHHHc-CCeEEEEEEecccCChhHHHHHH Confidence 34688999999999999999999988899999999987777877778888877765 35554322121111234556667 Q NP_000836.2 267 KRLLETP--NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRY 344 (908) Q Consensus 267 ~~l~~~~--~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~ 344 (908) ++++. . +.++|++......+..+++++++.|+..++.|++.+.|...............+.+.+.........+..+ T Consensus 248 ~~l~~-~~~~~~~iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~ 326 (496) T 3KS9_B 248 RKLRE-RLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDY 326 (496) T ss_dssp HHHHH-TTTTCCEEEEECCHHHHHHHHHHHHHHTCCSCCEEEECTTTTTCHHHHTTCHHHHTTCEEEEECCCCCHHHHHH T ss_pred HHHHH-hCCCCeEEEEEcCHHHHHHHHHHHHHcCCCCceEEEeeccccCCchhhccccchhcceEEEEecCCCCcCHHHH Confidence 77653 3 55788777666677788888888887544567766544332110000111122333322222222223222 Q NP_000836.2 345 FRSRTLANNRRNVWFAEFWEENFGCKLGSHGK-RNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDL 423 (908) Q Consensus 345 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~ 423 (908) +........+...++.++|++.+.+....... ...+...|.+++.... ......+++++|||++++++|++++.... T Consensus 327 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~ydav~~~a~al~~~~~~~ 404 (496) T 3KS9_B 327 FLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEE--NYVQDSKMGFVINAIYAMAHGLQNMHHAL 404 (496) T ss_dssp HTTCCTTTCCSCTTHHHHHHHHTTCBCC-------CCSSBCCSCCCTTT--TCCCCTTHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHhCCCCCCCCCCcHHHHHHHHcCccCCcccCCCCCcCccCCCCccccc--cccccchHHHHHHHHHHHHHHHHHHHHHh Confidence 21111111122345666666655542110000 0001112322111100 01234567789999999999999887543 Q NP_000836.2 424 CPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTP-VTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVE 500 (908) Q Consensus 424 ~~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~-v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~ 500 (908) +......|......++..+.+.|++..|.|.+| . ++||++|++...+.|++++..+ +...++.||.|+... .++.. T Consensus 405 ~~~~~~~c~~~~~~~~~~l~~~l~~~~f~g~tG-~~v~fd~~G~~~~~~~i~~~~~~~~~~~~~~~vg~~~~~~l~~~~~ 483 (496) T 3KS9_B 405 CPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSG-EEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDY 483 (496) T ss_dssp STTCSSCCGGGSSCCHHHHHHHHHTCEEECTTS-CEEECCTTSCCCCEEEEEEEEECSSSCEEEEEEEEEETTEEEECC- T ss_pred CCCCCCCchhcCCCCHHHHHHHHhcCceecCCC-CEEEeCCCCCCCCeEEEEEEEeCCCCceEEEEEEEEECCEEEEccc Confidence 322112232222245667888898889999988 7 9999999998888888887432 123689999999762 33334 Q NP_000836.2 501 DMQWAH 506 (908) Q Consensus 501 ~i~w~~ 506 (908) .+.|++ T Consensus 484 ~i~w~~ 489 (496) T 3KS9_B 484 KIQMNK 489 (496) T ss_dssp ------ T ss_pred eeeecC Confidence 677865 No 22 >4XAR_A Metabotropic glutamate receptor 3; mGluR2 mGluR3 ECD, SIGNALING PROTEIN; HET: 40F; 2.26A {Homo sapiens} Probab=99.85 E-value=1.6e-26 Score=260.59 Aligned_cols=462 Identities=47% Similarity=0.846 Sum_probs=277.1 Template_Neff=10.800 Q NP_000836.2 37 AHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQS 116 (908) Q Consensus 37 ~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~ 116 (908) ......+++++||+++|.++.......|+......+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+ T Consensus 32 ~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~~~~~A~~~iN~~~~~~~g~~l~l~~~d~~~~~~~a~~~~ 111 (517) T 4XAR_A 32 RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQS 111 (517) T ss_dssp CCCEEECCSEEEEEEECCEEECSTTCSEEEECCCCCCHHHHHHHHHHHHHTTCSSSSTTCCEEEEEEECTTCHHHHHHHH T ss_pred hcceeecCCEEEEEEeeceecCCCCCCCccccccccHHHHHHHHHHHHHHhcCCCCCCCCeEeEEEEeCCCCHHHHHHHH Confidence 34456688999999999987543233454332235677889999999999998888888999999999887755444333 Q NP_000836.2 117 LTFVQALIEK-DASDVKCANGDPPIF-TKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSR 194 (908) Q Consensus 117 ~~~~~~l~~~-~~~~~~~~~~~~~~~-~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~ 194 (908) .+++.+.... +.....|........ ....++++++|+.++.....++.++...++|+|++.+..+.+.+...++++++ T Consensus 112 ~~l~~~~~~~~~~~~~~c~~~~~~~~~~~~~~v~~iig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~ 191 (517) T 4XAR_A 112 LEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFAR 191 (517) T ss_dssp GGGTGGGC----------------------CCCSEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTTCTTEEE T ss_pred HHHHHhcccccchhhhcCCCCChhhhcCCCcceEEEEcCCCcHHHHHHHHHHHHhCCCeeecccCCcccCCccccCceee Confidence 3333210000 000000000000000 00025788999888877778888899999999998876665554445789999 Q NP_000836.2 195 VVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 195 ~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) +.|+....+.++++++.+++|++++++++++.++....+.+++.+++. ++++.....++......++...+++++...+ T Consensus 192 ~~p~~~~~~~al~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~l~~i~~~~~ 270 (517) T 4XAR_A 192 TVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLR-NISIATAEKVGRSNIRKSYDSVIRELLQKPN 270 (517) T ss_dssp SSCCHHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEECSSTTCCCHHHHHHHHHTCTT T ss_pred eCCCcHHHHHHHHHHHHHcCCcEEEEEEecCcchHHHHHHHHHHHHHC-CCEEEEEEecCcccccccHHHHHHHHHcCCC Confidence 999999999999999988999999999987778888888888887765 3555433222211122345556666631247 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNR 354 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~ 354 (908) +|+|++......+..+++++++.|+ ++.|++.+.|...............+.+.+.........+..++....+.... T Consensus 271 ~~~vvl~~~~~~~~~~l~~~~~~g~--~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~ 348 (517) T 4XAR_A 271 ARVVVLFMRSDDSRELIAAASRANA--SFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNH 348 (517) T ss_dssp CCEEEEECCHHHHHHHHHHHHHTTC--CCEEEECTTTTTCHHHHTTCTTTSTTCEEEEECCCCCHHHHHHHHTCCTTTCC T ss_pred ceEEEEECChHHHHHHHHHHHHcCC--CEEEEEecchhccchhhcCCcceecceEEEEEcccCCccHHHHHHhCCCCCCC Confidence 8888887777778889998888876 35677665544321110001122333333322222222333332221111122 Q NP_000836.2 355 RNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM 434 (908) Q Consensus 355 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~ 434 (908) ...++.++|++.+.+..... ......|...+.... .......++.++|||++++++|++++....+......|... T Consensus 349 ~~~~~~~~~~~~~~~~~~~~---~~~~~~~~~~~~~~~-~~~~~~~~~~~~ydav~~~a~al~~~~~~~~~~~~~~c~~~ 424 (517) T 4XAR_A 349 RNPWFRDFWEQKFQCSLQNK---RNHRRVCDKHLAIDS-SNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAM 424 (517) T ss_dssp SCTTHHHHHHHHTTSBC----------CBCCTTCCCCT-TTCCCCTTHHHHHHHHHHHHHHHHHHHHHHCTTCSSCCGGG T ss_pred CChHHHHHHHHHcCCccCCc---ccCCcccccccccCC-CccccccchhHHHHHHHHHHHHHHHHHHhhCCCCCCcchhh Confidence 33456666666554421100 000011211110000 00123456788999999999999998764432211223211 Q NP_000836.2 435 ST-IDGKELLGYIRAVNFNG-------SAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAH 506 (908) Q Consensus 435 ~~-~~~~~l~~~l~~~~f~G-------~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~ 506 (908) .. ..+..+.+.+++..|.| .+| ++.||.+|++...+.|++++..++...++.||.|+....++...+.|++ T Consensus 425 ~~~~~~~~l~~~l~~~~f~g~~~~~~~~tG-~v~fd~~G~r~~~~~i~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~~ 503 (517) T 4XAR_A 425 KILDGKKLYKDYLLKINFTAPFNPNKDADS-IVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSR 503 (517) T ss_dssp SSCCHHHCCCCCCSCEEECCC-----CCCC-EEECCTTSCCCCEEEEEEEEESSSCEEEEEEEEEESSEEECGGGCCCSC T ss_pred cccchHHHHHHHHhcCcccCCCCCCCCCCc-eeEeCCCCCCCCcEEEEEEEEeCCEEEEEEEEEEeeeEEeccccEEecC Confidence 11 12234667788888998 778 8999999999888999998743212368899999976444444677864 No 23 >6B7H_A Metabotropic glutamate receptor 3; mGluR3 Glutamate, MEMBRANE PROTEIN-AGONIST complex; HET: NAG, CWY; 2.82A {Homo sapiens} Probab=99.85 E-value=1.6e-26 Score=260.59 Aligned_cols=462 Identities=47% Similarity=0.846 Sum_probs=275.1 Template_Neff=10.800 Q NP_000836.2 37 AHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQS 116 (908) Q Consensus 37 ~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~ 116 (908) ......+++++||+++|.++.......|+......+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+ T Consensus 32 ~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~~~~~A~~~iN~~~~~~~g~~l~l~~~d~~~~~~~a~~~~ 111 (517) T 6B7H_A 32 RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQS 111 (517) T ss_dssp CCCEEC-CCEEEEEEECCEEC----CCCCEECCCCCCCHHHHHHHHHHHHTTCSSSSTTCCEEEEEEECTTCHHHHHHHH T ss_pred hcceeecCCEEEEEEeeceecCCCCCCCccccccccHHHHHHHHHHHHHHhcCCCCCCCCeEeEEEEeCCCCHHHHHHHH Confidence 34456688999999999987543233454332235677889999999999998888888999999999887755444333 Q NP_000836.2 117 LTFVQALIEK-DASDVKCANGDPPIF-TKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSR 194 (908) Q Consensus 117 ~~~~~~l~~~-~~~~~~~~~~~~~~~-~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~ 194 (908) .+++.+.... +.....|........ ....++++++|+.++.....++.++...++|+|++.+..+.+.+...++++++ T Consensus 112 ~~l~~~~~~~~~~~~~~c~~~~~~~~~~~~~~v~~iig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~ 191 (517) T 6B7H_A 112 LEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFAR 191 (517) T ss_dssp GGGTSTTC---------------------CCCEEEEECCSSHHHHHHHHHHHHTTTCCEEESSCCCGGGGCTTTCTTEEE T ss_pred HHHHHhcccccchhhhcCCCCChhhhcCCCcceEEEEcCCCcHHHHHHHHHHHHhCCCeeecccCCcccCCccccCceee Confidence 3333210000 000000000000000 00025788999888877778888899999999998876665554445789999 Q NP_000836.2 195 VVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 195 ~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) +.|+....+.++++++.+++|++++++++++.++....+.+++.+++. ++++.....++......++...+++++...+ T Consensus 192 ~~p~~~~~~~al~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~l~~i~~~~~ 270 (517) T 6B7H_A 192 TVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLR-NISIATAEKVGRSNIRKSYDSVIRELLQKPN 270 (517) T ss_dssp SSCCHHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHT-TCEEEEEEEESSSTTSCCHHHHHHHHHTCTT T ss_pred eCCCcHHHHHHHHHHHHHcCCcEEEEEEecCcchHHHHHHHHHHHHHC-CCEEEEEEecCcccccccHHHHHHHHHcCCC Confidence 999999999999999988999999999987778888888888887765 3555433222211122345556666631247 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNR 354 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~ 354 (908) +|+|++......+..+++++++.|+ ++.|++.+.|...............+.+.+.........+..++....+.... T Consensus 271 ~~~vvl~~~~~~~~~~l~~~~~~g~--~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~ 348 (517) T 6B7H_A 271 ARVVVLFMRSDDSRELIAAASRANA--SFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNH 348 (517) T ss_dssp CCEEEEECCHHHHHHHHHHHHTTTC--CCEEEECTTTTTCHHHHTTCHHHHTTCEEEEECCCCCHHHHHHHHHCCTTTCC T ss_pred ceEEEEECChHHHHHHHHHHHHcCC--CEEEEEecchhccchhhcCCcceecceEEEEEcccCCccHHHHHHhCCCCCCC Confidence 8888887777778889998888876 35677665544321110001122333333322222222333332221111122 Q NP_000836.2 355 RNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM 434 (908) Q Consensus 355 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~ 434 (908) ...++.++|++.+.+..... ......|...+.... .......++.++|||++++++|++++....+......|... T Consensus 349 ~~~~~~~~~~~~~~~~~~~~---~~~~~~~~~~~~~~~-~~~~~~~~~~~~ydav~~~a~al~~~~~~~~~~~~~~c~~~ 424 (517) T 6B7H_A 349 RNPWFRDFWEQKFQCSLQNK---RNHRRVCDKHLAIDS-SNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAM 424 (517) T ss_dssp SCTTHHHHHHHHTTCBC----------CBCCTTCCCCT-TTCCCCTTHHHHHHHHHHHHHHHHHHHHHHCTTCSSCCGGG T ss_pred CChHHHHHHHHHcCCccCCc---ccCCcccccccccCC-CccccccchhHHHHHHHHHHHHHHHHHHhhCCCCCCcchhh Confidence 33456666666554421100 000011211110000 00123456788999999999999998764432211223211 Q NP_000836.2 435 ST-IDGKELLGYIRAVNFNG-------SAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAH 506 (908) Q Consensus 435 ~~-~~~~~l~~~l~~~~f~G-------~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~ 506 (908) .. ..+..+.+.+++..|.| .+| ++.||.+|++...+.|++++..++...++.||.|+....++...+.|++ T Consensus 425 ~~~~~~~~l~~~l~~~~f~g~~~~~~~~tG-~v~fd~~G~r~~~~~i~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~~ 503 (517) T 6B7H_A 425 KILDGKKLYKDYLLKINFTAPFNPNKDADS-IVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSR 503 (517) T ss_dssp SSCCHHHCCCCCCSCEEECCC-----CCTT-EEECCTTSCCCCCEEEEEEEESSSSEEEEEEEEESSSEEECGGGCCCSC T ss_pred cccchHHHHHHHHhcCcccCCCCCCCCCCc-eeEeCCCCCCCCcEEEEEEEEeCCEEEEEEEEEEeeeEEeccccEEecC Confidence 11 12234667788888998 778 8999999999888999998743212368899999976444444677864 No 24 >1EWK_B METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1; SIGNAL TRANSDUCTION, NEUROTRANSMITTER, CNS, NEURON; HET: EPE, NAG, GLU; 2.2A {Rattus norvegicus} SCOP: c.93.1.1 Probab=99.85 E-value=1.8e-26 Score=258.44 Aligned_cols=464 Identities=42% Similarity=0.763 Sum_probs=275.1 Template_Neff=11.000 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYAL 113 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~ 113 (908) .....+++++||+++|+++... ....|+......+.+...|+++|++++|+++++++++++++.+.|+++++..+. T Consensus 5 ~~~~~~~~~~ig~l~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~a~~~in~~~~~~~~~~i~~~~~d~~~~~~~~~ 84 (490) T 1EWK_B 5 SVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVAL 84 (490) T ss_dssp CCEEECCSEEEEEEECSBCCCCGGGTTTTCCCSBCCCCCCHHHHHHHHHHHHHHTCSSSSTTCCEEEEEEECTTSHHHHH T ss_pred ceeEecCCEEEEEEEEeccCCCCCCCCCCCcccccccccHHHHHHHHHHHHHHhcCCCCCCCceEeeEEEecCCCHHHHH Confidence 3456778999999999987532 134676544445677889999999999998877788999999999988765444 Q NP_000836.2 114 EQSLTFVQALIE----KDASDVKCANGDP--PIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNT 187 (908) Q Consensus 114 ~~~~~~~~~l~~----~~~~~~~~~~~~~--~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~ 187 (908) +.+.+++..... +......|...+. ......+++++++|+.++.....++.++...++|+|++.+..+.+.+.. T Consensus 85 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~ 164 (490) T 1EWK_B 85 EQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKT 164 (490) T ss_dssp HHHHHHHC-----------------------------CCEEEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTT T ss_pred HHHHHHHHHccccccCCcccccccCCCCCCCCCCCCCCCeEEEEcCCCchHHHHHHHHhhhhCCCEEEeccCchhhcCcc Confidence 443333321000 0000000000000 0000015788999988877777778888999999999877665554433 Q NP_000836.2 188 RYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIK 267 (908) Q Consensus 188 ~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~ 267 (908) .+++++++.++....+.++++++++++|++|++++.++.++....+.+++.+++. ++++.....+.......++...++ T Consensus 165 ~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~vl~~~~~~~~~~~~~~~~~~~~~-g~~i~~~~~~~~~~~~~~~~~~~~ 243 (490) T 1EWK_B 165 LYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQE-GLCIAHSDKIYSNAGEKSFDRLLR 243 (490) T ss_dssp TCTTEEESSCCTHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEECTTCCHHHHHHHHH T ss_pred cccceeecCCChHHHHHHHHHHHHHcCCCEEEEEEeCCccchhhHHHHHHHHHHc-CceEEEeeEeccccchHHHHHHHH Confidence 4689999999988889999999988899999999987778887888888877765 355543321211112335566677 Q NP_000836.2 268 RLLETP--NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 268 ~l~~~~--~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) +++. . +.++|++......+..+++++++.|+.+++.|++.+.|...............+.+.+.........+..++ T Consensus 244 ~l~~-~~~~~~~iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 322 (490) T 1EWK_B 244 KLRE-RLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYF 322 (490) T ss_dssp HHHH-TTTTCCEEEEECCHHHHHHHHHHHHHHTCCSCCEEEECTTTTTCHHHHTTCHHHHTTCEEEEECCCCCHHHHHHH T ss_pred HHHH-hCCCCeEEEEEcChHHHHHHHHHHHHcCCCCeeEEEecccccCchhhhhccccccceeEEEEecCCCCCCHHHHH Confidence 7753 3 457787776666778899999888875445677665443321100001111223222221111112222222 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGK-RNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLC 424 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~ 424 (908) ........+...++.++|++.+.+....... .......|++++.... ......+++.+|||++++++|++++....+ T Consensus 323 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~yDav~~~a~al~~~~~~~~ 400 (490) T 1EWK_B 323 LKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEE--NYVQDSKMGFVINAIYAMAHGLQNMHHALC 400 (490) T ss_dssp TTCCTTTCCSCTTHHHHHHHHTTCBCTTCTTCCTTCCSBCCSCCCTTT--TCCCCTTHHHHHHHHHHHHHHHHHHHHHHS T ss_pred HhCCCCCCCCCCcHHHHHHHHcCccCCcccCCCCccCccCCCCccccc--ccccccchHHHHHHHHHHHHHHHHHHHHhC Confidence 1111111123345666666665542210000 0000112322111100 011345677899999999999998865433 Q NP_000836.2 425 PGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTP-VTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVED 501 (908) Q Consensus 425 ~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~-v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~~ 501 (908) ......|......++..+.+.|++..|.|.+| . +.||++|++...+.|.+++..+ +...++.||.|+... .++... T Consensus 401 ~~~~~~c~~~~~~~~~~l~~~l~~~~f~G~tG-~~v~fd~~g~~~~~~~i~~~~~~~~~~~~~~~vg~~~~~~~~~~~~~ 479 (490) T 1EWK_B 401 PGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSG-EEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYK 479 (490) T ss_dssp TTCSSCCGGGSSCCHHHHHHHHHTCCEECTTS-CEECCCTTSCCCCEEEEEEEEECSSSCEEEEEEEEEETTEEEECTTT T ss_pred CCCCCCchhcCCCCHHHHHHHHhcCceecCCC-CeEEECCCCCCCCeEEEEEEEEccCCeeEEEEEEEEECCEEEEccce Confidence 21112232222235667888898889999998 7 9999999988888888887432 223689999999762 233346 Q NP_000836.2 502 MQWAH 506 (908) Q Consensus 502 i~w~~ 506 (908) +.|++ T Consensus 480 ~~w~~ 484 (490) T 1EWK_B 480 IQMNK 484 (490) T ss_dssp C---- T ss_pred eeecC Confidence 78865 No 25 >1EWT_A METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1; SIGNAL TRANSDUCTION, NEUROTRANSMITTER, CNS, NEURON; HET: SO4, NAG; 3.7A {Rattus norvegicus} SCOP: c.93.1.1 Probab=99.85 E-value=1.8e-26 Score=258.44 Aligned_cols=464 Identities=42% Similarity=0.763 Sum_probs=275.4 Template_Neff=11.000 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYAL 113 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~ 113 (908) .....+++++||+++|+++... ....|+......+.+...|+++|++++|+++++++++++++.+.|+++++..+. T Consensus 5 ~~~~~~~~~~ig~l~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~a~~~in~~~~~~~~~~i~~~~~d~~~~~~~~~ 84 (490) T 1EWT_A 5 SVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVAL 84 (490) T ss_dssp CEEEECCSEEEEEEECCBCCCCGGGTTTTCCCSBCCCCCCCHHHHHHHHHHHHHHCSSSSTTCCEEEEEEECTTCHHHHH T ss_pred ceeEecCCEEEEEEEEeccCCCCCCCCCCCcccccccccHHHHHHHHHHHHHHhcCCCCCCCceEeeEEEecCCCHHHHH Confidence 3456778999999999987532 134676544445677889999999999998877788999999999988765444 Q NP_000836.2 114 EQSLTFVQALIE----KDASDVKCANGDP--PIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNT 187 (908) Q Consensus 114 ~~~~~~~~~l~~----~~~~~~~~~~~~~--~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~ 187 (908) +.+.+++..... +......|...+. ......+++++++|+.++.....++.++...++|+|++.+..+.+.+.. T Consensus 85 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~ 164 (490) T 1EWT_A 85 EQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKT 164 (490) T ss_dssp HHHHHHHHHHHHTTC----------------------CCEEEEECCSCHHHHHHHHHHHTTTTCCEEESSCCCGGGGCTT T ss_pred HHHHHHHHHccccccCCcccccccCCCCCCCCCCCCCCCeEEEEcCCCchHHHHHHHHhhhhCCCEEEeccCchhhcCcc Confidence 443333321000 0000000000000 0000015788999988877777778888999999999877665554433 Q NP_000836.2 188 RYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIK 267 (908) Q Consensus 188 ~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~ 267 (908) .+++++++.++....+.++++++++++|++|++++.++.++....+.+++.+++. ++++.....+.......++...++ T Consensus 165 ~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~vl~~~~~~~~~~~~~~~~~~~~~-g~~i~~~~~~~~~~~~~~~~~~~~ 243 (490) T 1EWT_A 165 LYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQE-GLCIAHSDKIYSNAGEKSFDRLLR 243 (490) T ss_dssp TCTTEEESSBCSHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHH-CCEEEEEEEECTTCCHHHHHHHHH T ss_pred cccceeecCCChHHHHHHHHHHHHHcCCCEEEEEEeCCccchhhHHHHHHHHHHc-CceEEEeeEeccccchHHHHHHHH Confidence 4689999999988889999999988899999999987778887888888877765 355543321211112335566677 Q NP_000836.2 268 RLLETP--NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 268 ~l~~~~--~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) +++. . +.++|++......+..+++++++.|+.+++.|++.+.|...............+.+.+.........+..++ T Consensus 244 ~l~~-~~~~~~~iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 322 (490) T 1EWT_A 244 KLRE-RLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYF 322 (490) T ss_dssp HHHH-TTTTTTEEEEECCHHHHHHHHHHHHHTTCCSSCEEEECTTTTTCTTTSSSTTTTTTTCEEEEECCCCCHHHHHHH T ss_pred HHHH-hCCCCeEEEEEcChHHHHHHHHHHHHcCCCCeeEEEecccccCchhhhhccccccceeEEEEecCCCCCCHHHHH Confidence 7753 3 457787776666778899999888875445677665443321100001111223222221111112222222 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGK-RNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLC 424 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~ 424 (908) ........+...++.++|++.+.+....... .......|++++.... ......+++.+|||++++++|++++....+ T Consensus 323 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~yDav~~~a~al~~~~~~~~ 400 (490) T 1EWT_A 323 LKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEE--NYVQDSKMGFVINAIYAMAHGLQNMHHALC 400 (490) T ss_dssp HSCCTTTCCSCTTHHHHHHHHHTCBCSSCSSCCTTCSSBCCSCCCTTT--TCCCCSTHHHHHHHHHHHHHHHHHHHHHHS T ss_pred HhCCCCCCCCCCcHHHHHHHHcCccCCcccCCCCccCccCCCCccccc--ccccccchHHHHHHHHHHHHHHHHHHHHhC Confidence 1111111123345666666665542210000 0000112322111100 011345677899999999999998865433 Q NP_000836.2 425 PGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTP-VTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVED 501 (908) Q Consensus 425 ~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~-v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~~ 501 (908) ......|......++..+.+.|++..|.|.+| . +.||++|++...+.|.+++..+ +...++.||.|+... .++... T Consensus 401 ~~~~~~c~~~~~~~~~~l~~~l~~~~f~G~tG-~~v~fd~~g~~~~~~~i~~~~~~~~~~~~~~~vg~~~~~~~~~~~~~ 479 (490) T 1EWT_A 401 PGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSG-EEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYK 479 (490) T ss_dssp SSCSSCCGGGSSCCHHHHHHHHHTCEEECTTS-CEEECCTTSCBCCEEEEEEEEECSSSCEEEEEEEEEETTEEEECGGG T ss_pred CCCCCCchhcCCCCHHHHHHHHhcCceecCCC-CeEEECCCCCCCCeEEEEEEEEccCCeeEEEEEEEEECCEEEEccce Confidence 21112232222235667888898889999998 7 9999999988888888887432 223689999999762 233346 Q NP_000836.2 502 MQWAH 506 (908) Q Consensus 502 i~w~~ 506 (908) +.|++ T Consensus 480 ~~w~~ 484 (490) T 1EWT_A 480 IQMNK 484 (490) T ss_dssp C---- T ss_pred eeecC Confidence 78865 No 26 >5C5C_A Metabotropic glutamate receptor 7; GLUTAMATE RECEPTORS, GLUTAMIC ACID BINDING; HET: NAG, UNX; 1.862A {Homo sapiens} Probab=99.85 E-value=2e-26 Score=257.70 Aligned_cols=468 Identities=73% Similarity=1.247 Sum_probs=271.6 Template_Neff=11.400 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ......++++||+++|.++.......|+......+.....|+++|++++|+++++++|+++++++.|++++.....+.+. T Consensus 9 ~~~~~~~~i~ig~~~p~~~~~~~~~~~~~~~~~~g~~~~~~~~~A~~~in~~~~~~~g~~i~~~~~d~~~~~~~~~~~~~ 88 (481) T 5C5C_A 9 HSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL 88 (481) T ss_dssp CEEEECCSEEEEEEECCEEECSSSCSEEEECCCCCCCHHHHHHHHHHHHHTCTTSSTTCCEEEEEEECTTCHHHHHHHHG T ss_pred ceeEeCCCEEEEEEeeeeecCCCCCCCCcccccccHHHHHHHHHHHHHHcCCCCCCCCceeeeEEEcCCCCHHHHHHHHH Confidence 34566789999999999875332234543333356778899999999999988887789999999988765333233333 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +.+++++........|...........++++++||+.++.....++.++...++|+|++.+..+.+.+...+++++++.+ T Consensus 89 ~~~~~l~~~~~~~~~c~~~~~~~~~~~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~ 168 (481) T 5C5C_A 89 TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVP 168 (481) T ss_dssp GGGTTTC------------------CCCCEEEEECCSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCTTTCTTEEESSC T ss_pred HHHHHHHccCCCCcccCCCCCCCccccccEEEEEcCCCcHHHHHHHHHHHHhCCCEEecCCCCcccCCCcccccccccCC Confidence 33333321000000000000000001257889999988877777888899999999998876655544335788999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE--PRPGEFEKIIKRLLETPNA 275 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~--~~~~~~~~~~~~l~~~~~~ 275 (908) +...+++++++++++++|+++++++.++.++....+.+++.+++.+++++.....+... ....++...+++++...++ T Consensus 169 ~~~~~~~~l~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~~g~~v~~~~~~~~~~~~~~~~~~~~~~~i~~~~~~ 248 (481) T 5C5C_A 169 PDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLSIAQSVRIPQERKDRTIDFDRIIKQLLDTPNS 248 (481) T ss_dssp CHHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHHSSCEEEEEEEECCCCTTCCCCHHHHHHHHHTSSSC T ss_pred CCHHHHHHHHHHHHHhCCCEEEEEEeCCchhHHHHHHHHHHHHHcCCceEEEEEEcCCccCCchhcHHHHHHHHHcCCCc Confidence 99889999999998899999999998777888888888877765423444433222210 0123455566666521368 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRR 355 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 355 (908) |+|++......+..+++++++.++..++.|++.+.|...............+.+.+.+.......|..++....+..... T Consensus 249 ~~vv~~~~~~~~~~~l~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 328 (481) T 5C5C_A 249 RAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR 328 (481) T ss_dssp CEEEEEECHHHHHHHHHHHHHSSSCCCEEEEESSCC---------CCCCCTTCEEEEECCCCCHHHHHHHHTCCTTTCTT T ss_pred eEEEEEcCHHHHHHHHHHHHHhccCCCEEEEEeccccCCCcccccccceecceEEEEeccccCccHHHHHhcCCCccCCC Confidence 88888777777888999998887653456776654432210000011122333332221111122222211100011123 Q NP_000836.2 356 NVWFAEFWEENFGCKLGSHGKR-NSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM 434 (908) Q Consensus 356 ~~~~~~~~~~~~~~~~~~~~~~-~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~ 434 (908) ..+|.++|++.+++........ ..+...|................+++++|||+++++.++++.....+....+.|... T Consensus 329 ~~~f~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~yDav~~~a~al~~~~~~~~~~~~~~c~~~ 408 (481) T 5C5C_A 329 NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEM 408 (481) T ss_dssp STTHHHHHHHHTTCBC----------CCBCCSCCCTTTTSCCCCCTTHHHHHHHHHHHHHHHHHHHHHHCCSCSSCCHHH T ss_pred ChHHHHHHHHHcCCcCcCCCCCcccCCCCCCCCccccCcccccccccHHHHHHHHHHHHHHHHHHHHhhcCCCCCCChHH Confidence 3455666665554321100000 000111211100000000122346788999999999999998754332111223221 Q NP_000836.2 435 STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 ~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ...++..+.+.|++.+|.|.+|..++||++|++...+.+++++..+ +...++.||.|+....+....+.|. T Consensus 409 ~~~~~~~l~~~l~~~~f~G~tG~~v~fd~~g~~~~~~~i~~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~ 480 (481) T 5C5C_A 409 EQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWG 480 (481) T ss_dssp HHHHHHHHHHHHHTCCEECTTSSEECCCTTSBCCCCEEEEEEECCC---CEEEEEEEESSSEEECGGGSCC- T ss_pred HhhcHHHHHHHHhcCceecCCCCeEEeCCCCCCCCeEEEEEEEecCCCCCceEEeEEEccceeEehhhceec Confidence 1224456778888889999887459999999988788888887432 1245789999997654544467773 No 27 >3SM9_A Metabotropic glutamate receptor 3; Structural Genomics, Structural Genomics Consortium; HET: SO4, Z99; 2.26A {Homo sapiens} Probab=99.84 E-value=2.4e-26 Score=256.80 Aligned_cols=459 Identities=47% Similarity=0.859 Sum_probs=274.8 Template_Neff=11.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...+++++||+++|.++.......|+......+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+.++ T Consensus 8 ~~~~~~i~ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~a~~~iN~~~~~~~g~~l~l~~~D~~~~~~~~~~~~~~l 87 (479) T 3SM9_A 8 IKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEF 87 (479) T ss_dssp EEECCSEEEEEEECCEEECC-CCSEEEECCCCCCCHHHHHHHHHHHHHHCSSSSTTCCEEEEEEECTTCHHHHHHHHHHH T ss_pred eEecCCEEEEeeeeceecCCCCCCCCcccccccHHHHHHHHHHHHHHhcCCCCCCCCeEEEEEeeCCCCHHHHHHHHHHH Confidence 45678999999999987543234565433345677889999999999998888788999999999887655444333333 Q NP_000836.2 120 VQALIEK-DASDVKCANGDPPIF-TKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 120 ~~~l~~~-~~~~~~~~~~~~~~~-~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +.+.... +.....|........ ....++++++|+.++.....++.++...++|+|++....+.+.+...+++++++.+ T Consensus 88 ~~~~~~~~~~~~~~c~~~~~~~~~~~~~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~~~~ 167 (479) T 3SM9_A 88 VRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVP 167 (479) T ss_dssp HHTCC-----------------------CEEEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTTTTTEEESSC T ss_pred HHhcccCccchhhcCCCCChhhhcCCCcceEEEEcCCChHHHHHHHHHHHHhCCCEEecCccChhhcCcccCCceeeeCC Confidence 3210000 000000000000000 00025789999988877778888889999999998776655544335788999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) +....+.++++++.+++|+++++++.++.++....+.+++.+++. ++++.....++......++...++++....++|+ T Consensus 168 ~~~~~~~a~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~i~~~~~~~~ 246 (479) T 3SM9_A 168 PDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLR-NISIATAEKVGRSNIRKSYDSVIRELLQKPNARV 246 (479) T ss_dssp CTHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHTT-TCEEEEEEEECC--CHHHHHHHHHHHHTCTTCCE T ss_pred ChHHHHHHHHHHHHHcCCcEEEEEEecCchhHHHHHHHHHHHHHC-CcEEEEEEEeCcccccccHHHHHHHHHhCCCccE Confidence 998899999999988999999999987778888888888887775 4555443323211112345556666621247888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) |++......+..+++++++.|+ ++.|++.+.|...............|.+.+.........|..++....+...+.++ T Consensus 247 vvl~~~~~~~~~~l~~~~~~g~--~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 324 (479) T 3SM9_A 247 VVLFMRSDDSRELIAAASRANA--SFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNP 324 (479) T ss_dssp EEEECCHHHHHHHHHHHHHTTC--CCEEEECTTTTTCHHHHTTCTTTTTTCEEEEECCCCCHHHHHHHHTCCTTTCTTCT T ss_pred EEEEcChHHHHHHHHHHHHcCC--CEEEEEeCcccccchhHcCCcceeceeEEEEEccccChhHHHHHHhCCCCCCCCCH Confidence 8887777778889999888876 35677665444321110001122334333332222222333333222111223345 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTI 437 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~ 437 (908) ++.++|++.+.+..... ......|...+..... ....+.++.++|||++++++|++++....+......|...... T Consensus 325 ~~~~~~~~~~~~~~~~~---~~~~~~c~~~~~~~~~-~~~~~~~~~~~ydav~~~a~al~~~~~~~~~~~~~~c~~~~~~ 400 (479) T 3SM9_A 325 WFRDFWEQKFQCSLQNK---RNHRRVCDKHLAIDSS-NYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKIL 400 (479) T ss_dssp THHHHHHHHHTCBCCC------CSCBCCTTCCCCTT-TCCCCTTHHHHHHHHHHHHHHHHHHHHHHSTTCSSCCHHHHSC T ss_pred HHHHHHHHHcCCccCCc---cCCCCccCccccccCc-cccccccchHHHHHHHHHHHHHHHHHHhhCCCCCCCchhhccc Confidence 66777776665432110 0001122211111000 0113456778999999999999998764332211223211111 Q NP_000836.2 438 D-GKELLGYIRAVNFNG-------SAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAH 506 (908) Q Consensus 438 ~-~~~l~~~l~~~~f~G-------~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~ 506 (908) + +..+.+.|++..|.| .+| .|.|+++|++...+.+++++..++...++.||.|+....++...+.|++ T Consensus 401 ~~~~~l~~~l~~~~f~g~~~~~~~~~G-~v~f~~~g~r~~~~~i~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~~ 476 (479) T 3SM9_A 401 DGKKLYKDYLLKINFTAPFNPNKDADS-IVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSR 476 (479) T ss_dssp CHHHCCCCCGGGCCEECTTC-----CC-EECCCTTCBCCCCEEEEEEEESSSCEEEEEEEEESSSEEECGGGCCCC- T ss_pred ChHHHHHHHHhcCcccCCCCCCCCCCC-eeEeCCCCCCCCcEEEEEEEEeCCeEEEEEEEEEeeeeEecccceeecc Confidence 1 224667788888988 777 8999999999888899988743212358899999876444434577754 No 28 >4XAQ_A Metabotropic glutamate receptor 2; mGluR2 mGluR3, SIGNALING PROTEIN; HET: 40F, SO4; 2.21A {Homo sapiens} Probab=99.83 E-value=9.3e-26 Score=253.40 Aligned_cols=453 Identities=45% Similarity=0.841 Sum_probs=270.3 Template_Neff=10.900 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.+........|+......+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+.++ T Consensus 28 ~~~~~~i~Ig~~~p~~~~~g~~~~c~~~~~~~~~~~~~~~~~a~~~in~~~~~~~~~~i~~~~~d~~~~~~~~~~~~~~l 107 (503) T 4XAQ_A 28 LTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDF 107 (503) T ss_dssp EEECCSEEEEEEECCEEECCTTCSEEEECCCCCCCHHHHHHHHHHHHHHCTTSSTTCCEEEEEEECTTCHHHHHHHHHHH T ss_pred EEeCCCEEEEEEeeceeCCCCcccCCcccccccHHHHHHHHHHHHHHhcCCCCCCCCeeeEEEEeCCCCHHHHHHHHHHH Confidence 46778999999999972211122354332235667889999999999998777778999999999887655443333333 Q NP_000836.2 120 VQALIEK--DASDVKCANGDPPIFT-KPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 120 ~~~l~~~--~~~~~~~~~~~~~~~~-~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +...... ......|...++.|.. ..+++++++|+.++.....++.+++..++|+|++.+..+.+.++..+++++++. T Consensus 108 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~ 187 (503) T 4XAQ_A 108 VRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTV 187 (503) T ss_dssp HTTTC-----------------------CCCCEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTTCTTEEESS T ss_pred HHHHhccCCCCCceeCCCCccccCCCCCCceEEEEcCCCcHHHHHHHHHHHHhCCCEEecCCCCccccCccccCceeeeC Confidence 3210000 0000000000000000 013688999988887777888889999999999877666555444578899999 Q NP_000836.2 197 PPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNAR 276 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~ 276 (908) ++....+.++++++++++|+++++++.+++++....+.+++.+++. ++++.....++......++...++++....+++ T Consensus 188 ~~~~~~~~~l~~~l~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~i~~~~~~~ 266 (503) T 4XAQ_A 188 PPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARAR-NISVATSEKVGRAMSRAAFEGVVRALLQKPSAR 266 (503) T ss_dssp CCHHHHHHHHHHHHHHHTCCEEEEEEESSTTHHHHHHHHHHHHHHT-TCEEEEEEEECTTCCHHHHHHHHHHHHTCTTCC T ss_pred CChHHHHHHHHHHHHHcCCcEEEEEEeCCcchhHHHHHHHHHHHHC-CcEEEeEEecccccCHHHHHHHHHHHHcCCCce Confidence 9998889999999988999999999987778888888888877765 355543332321012234556666664224788 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) +|++......+..+++++++.|+ ++.|++.+.|...............+.+.+.......+.|..++....+...+.. T Consensus 267 ~iv~~~~~~~~~~~l~~~~~~g~--~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 344 (503) T 4XAQ_A 267 VAVLFTRSEDARELLAASQRLNA--SFTWVASDGWGALEEVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRN 344 (503) T ss_dssp EEEEECCHHHHHHHHHHHHHTTC--CCEEEECTTTTTCHHHHTTCHHHHTTCEEEEESCCCCTTHHHHHHTCCTTTCCSC T ss_pred EEEEEcChHHHHHHHHHHHHhCC--CEEEEEeCCcccchHHHhcCcccccceEEEEeccccCccHHHHHHcCCcCCCCCC Confidence 88887777778888988888877 3567766544332110000112233444333222222233322221111111233 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMST 436 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~ 436 (908) .++.++|++.+.+.... ..|..... .. ....+..++..+|||+++++.|+++.....+......|..... T Consensus 345 ~~~~~~~~~~~~~~~~~--------~~~~~~~~-~~-~~~~~~~~a~~~yDav~~~a~al~~~~~~~~~~~~~~c~~~~~ 414 (503) T 4XAQ_A 345 PWFREFWEQRFRCSFRQ--------RDCAAHSL-RA-VPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRP 414 (503) T ss_dssp TTHHHHHHHHTTCCSSS--------CCCSSCCT-TT-SCCCCCTTHHHHHHHHHHHHHHHHHHHHHHCCSCSSCCGGGSS T ss_pred HHHHHHHHHHhCCccCC--------CCCCCccc-cc-CCcccccchhHHHHHHHHHHHHHHHHHHHHCCCCCCCchhcCC Confidence 45666666655542110 01211100 00 0012334577899999999999999875433221122322112 Q NP_000836.2 437 IDGKE-LLGYIRAVNFN------GSAGTPVTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQLHLKVEDMQWAH 506 (908) Q Consensus 437 ~~~~~-l~~~l~~~~f~------G~~G~~v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~~~~~~~i~w~~ 506 (908) .++.. +.+.|++..|. |.+| .++||++|++...+.+++++..+ +...++.||.|++...++...+.|++ T Consensus 415 ~~~~~~~~~~l~~~~f~~~~~~~G~~G-~v~fd~~g~~~~~~~v~~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~~ 491 (503) T 4XAQ_A 415 VNGRRLYKDFVLNVKFDAPFRPADTHN-EVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWAS 491 (503) T ss_dssp CCHHHCCCCCGGGCCEECTTCCSSCCC-EECCCTTSCCCCCEEEEEEEECTTSCEEEEEEEEESSSEEECGGGSCC-- T ss_pred cCHHHHHHHHHHhCeecCCCCCCCCCC-cEEeCCCCCCCCeEEEEEEEEcCCCceEEEEEEEEcCCcEEccceeeecC Confidence 23334 33567777787 7888 89999999998888888887431 12258899999976544444678865 No 29 >5CNI_A Metabotropic glutamate receptor 2; receptor, glutamate, metabotropic, SIGNALING PROTEIN; HET: GGL, NAG; 2.69A {Homo sapiens} Probab=99.83 E-value=9.3e-26 Score=253.40 Aligned_cols=453 Identities=45% Similarity=0.841 Sum_probs=270.0 Template_Neff=10.900 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.+........|+......+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+.++ T Consensus 28 ~~~~~~i~Ig~~~p~~~~~g~~~~c~~~~~~~~~~~~~~~~~a~~~in~~~~~~~~~~i~~~~~d~~~~~~~~~~~~~~l 107 (503) T 5CNI_A 28 LTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDF 107 (503) T ss_dssp EEECCSEEEEEEECCEEECCSSCSEEEECCCCCCCHHHHHHHHHHHHTTCTTSSTTCCEEEEEEECTTCHHHHHHHHHHH T ss_pred EEeCCCEEEEEEeeceeCCCCcccCCcccccccHHHHHHHHHHHHHHhcCCCCCCCCeeeEEEEeCCCCHHHHHHHHHHH Confidence 46778999999999972211122354332235667889999999999998777778999999999887655443333333 Q NP_000836.2 120 VQALIEK--DASDVKCANGDPPIFT-KPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 120 ~~~l~~~--~~~~~~~~~~~~~~~~-~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +...... ......|...++.|.. ..+++++++|+.++.....++.+++..++|+|++.+..+.+.++..+++++++. T Consensus 108 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~ 187 (503) T 5CNI_A 108 VRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTV 187 (503) T ss_dssp HSCC------------------------CCCCEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTTCTTEEESS T ss_pred HHHHhccCCCCCceeCCCCccccCCCCCCceEEEEcCCCcHHHHHHHHHHHHhCCCEEecCCCCccccCccccCceeeeC Confidence 3210000 0000000000000000 013688999988887777888889999999999877666555444578899999 Q NP_000836.2 197 PPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNAR 276 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~ 276 (908) ++....+.++++++++++|+++++++.+++++....+.+++.+++. ++++.....++......++...++++....+++ T Consensus 188 ~~~~~~~~~l~~~l~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~i~~~~~~~ 266 (503) T 5CNI_A 188 PPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARAR-NISVATSEKVGRAMSRAAFEGVVRALLQKPSAR 266 (503) T ss_dssp CCTHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHTT-TCEEEEEEEECSSCCHHHHHHHHHHHHTCTTCC T ss_pred CChHHHHHHHHHHHHHcCCcEEEEEEeCCcchhHHHHHHHHHHHHC-CcEEEeEEecccccCHHHHHHHHHHHHcCCCce Confidence 9998889999999988999999999987778888888888877765 355543332321012234556666664224788 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) +|++......+..+++++++.|+ ++.|++.+.|...............+.+.+.......+.|..++....+...+.. T Consensus 267 ~iv~~~~~~~~~~~l~~~~~~g~--~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 344 (503) T 5CNI_A 267 VAVLFTRSEDARELLAASQRLNA--SFTWVASDGWGALEEVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRN 344 (503) T ss_dssp EEEEECCHHHHHHHHHHHHHTTC--CCEEEECTTTTTCHHHHTTCHHHHTTCEEEEECCCCCHHHHHHHHTCCTTTCCSC T ss_pred EEEEEcChHHHHHHHHHHHHhCC--CEEEEEeCCcccchHHHhcCcccccceEEEEeccccCccHHHHHHcCCcCCCCCC Confidence 88887777778888988888877 3567766544332110000112233444333222222233322221111111233 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMST 436 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~ 436 (908) .++.++|++.+.+.... ..|..... .. ....+..++..+|||+++++.|+++.....+......|..... T Consensus 345 ~~~~~~~~~~~~~~~~~--------~~~~~~~~-~~-~~~~~~~~a~~~yDav~~~a~al~~~~~~~~~~~~~~c~~~~~ 414 (503) T 5CNI_A 345 PWFREFWEQRFRCSFRQ--------RDCAAHSL-RA-VPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRP 414 (503) T ss_dssp TTHHHHHHHHHTCCCC---------CCSTTCCT-TT-SCCCCCTTHHHHHHHHHHHHHHHHHHHHHHCTTCSSCCGGGSS T ss_pred HHHHHHHHHHhCCccCC--------CCCCCccc-cc-CCcccccchhHHHHHHHHHHHHHHHHHHHHCCCCCCCchhcCC Confidence 45666666655542110 01211100 00 0012334577899999999999999875433221122322112 Q NP_000836.2 437 IDGKE-LLGYIRAVNFN------GSAGTPVTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQLHLKVEDMQWAH 506 (908) Q Consensus 437 ~~~~~-l~~~l~~~~f~------G~~G~~v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~~~~~~~i~w~~ 506 (908) .++.. +.+.|++..|. |.+| .++||++|++...+.+++++..+ +...++.||.|++...++...+.|++ T Consensus 415 ~~~~~~~~~~l~~~~f~~~~~~~G~~G-~v~fd~~g~~~~~~~v~~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~~ 491 (503) T 5CNI_A 415 VNGRRLYKDFVLNVKFDAPFRPADTHN-EVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWAS 491 (503) T ss_dssp CCHHHCCCCCGGGCCEECTTCCTTCCC-EECCCTTSCCCCEEEEEEEEECC--CEEEEEEEEEESSEEECTTSSCC-- T ss_pred cCHHHHHHHHHHhCeecCCCCCCCCCC-cEEeCCCCCCCCeEEEEEEEEcCCCceEEEEEEEEcCCcEEccceeeecC Confidence 23334 33567777787 7888 89999999998888888887431 12258899999976544444678865 No 30 >5CNJ_A Metabotropic glutamate receptor 2; glutamate receptor analog, SIGNALING PROTEIN; HET: 52Q, NAG; 2.65A {Homo sapiens} Probab=99.83 E-value=1.1e-25 Score=252.80 Aligned_cols=454 Identities=45% Similarity=0.841 Sum_probs=271.0 Template_Neff=10.800 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||+++|.+........|+......+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+.+ T Consensus 27 ~~~~~~~i~Ig~~~p~~~~~g~~~~c~~~~~~~~~~~~~~~~~a~~~in~~~~~~~~~~i~~~~~d~~~~~~~~~~~~~~ 106 (503) T 5CNJ_A 27 VLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALD 106 (503) T ss_dssp CEEECCSEEEEEEECCEEECCTTCSEEEECCCCCCCHHHHHHHHHHHHTTCSSSSSSCCEEEEEEECTTCHHHHHHHGGG T ss_pred eEEeCCCEEEEEeeecccCCCCCCCCCCccccccHHHHHHHHHHHHHHhcCCCCCCCCeeeEEEEcCCCCHHHHHHHHHH Confidence 35677899999999997321112235433223456788999999999999877777899999999988775544433333 Q NP_000836.2 119 FVQALIE--KDASDVKCANGDPPIF-TKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRV 195 (908) Q Consensus 119 ~~~~l~~--~~~~~~~~~~~~~~~~-~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~ 195 (908) ++..... .......|...++.+. ...++++++||+.++.....++.++...++|+|++.+..+.+.++..+++++++ T Consensus 107 l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~ 186 (503) T 5CNJ_A 107 FVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFART 186 (503) T ss_dssp GTTTTC----------------------CCCEEEEEECSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCTTTCTTEEES T ss_pred HHHHHhccCCCCCceeCCCCccccCCCCCCceEEEEcCCCcHHHHHHHHHHHHhCCCEEecCcCCccccCCccCCceeee Confidence 3321000 0000000000000000 001468899998887777778888899999999988766655443357889999 Q NP_000836.2 196 VPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNA 275 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 275 (908) .++....+.++++++++++|++|++++.+++++....+.+++.+++. ++++.....++......++...++++.+..++ T Consensus 187 ~p~~~~~~~a~~~~l~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 265 (503) T 5CNJ_A 187 VPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARAR-NISVATSEKVGRAMSRAAFEGVVRALLQKPSA 265 (503) T ss_dssp SCCHHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHT-TCEEEEEEEECSSCCHHHHHHHHHHHHTSSSC T ss_pred CCChHHHHHHHHHHHHHcCCcEEEEEEeCCcchhHHHHHHHHHHHHC-CcEEEEEEecccccCHHHHHHHHHHHHcCCCc Confidence 99998889999999988899999999987778888888888887765 35554332232101223455666666422478 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRR 355 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 355 (908) |+|++......+..+++++++.|+ ++.|++.+.|...............|.+.+.......+.|..++....+...+. T Consensus 266 ~~iv~~~~~~~~~~~l~~~~~~g~--~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 343 (503) T 5CNJ_A 266 RVAVLFTRSEDARELLAASQRLNA--SFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSR 343 (503) T ss_dssp CEEEEECCHHHHHHHHHHHHHTTC--CCEEEECTTTTTCHHHHTTCHHHHTTCEEEEECCCCCHHHHHHHHTCCTTTCTT T ss_pred eEEEEEcChHHHHHHHHHHHHhCC--CEEEEEeCccccchhHHccCcccccceEEEEeccccCccHHHHHhcCCCCCCCC Confidence 888887766677888888888776 356776654433211000011233344433322222222322222111111123 Q NP_000836.2 356 NVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMS 435 (908) Q Consensus 356 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~ 435 (908) ..++.++|++.+.+.... ..|.... ... .......++..+|||++++++|+++.....+......|.... T Consensus 344 ~~~f~~~~~~~~~~~~~~--------~~~~~~~-~~~-~~~~~~~~~~~~yDav~~~a~al~~~~~~~~~~~~~~c~~~~ 413 (503) T 5CNJ_A 344 NPWFREFWEQRFRCSFRQ--------RDCAAHS-LRA-VPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMR 413 (503) T ss_dssp CTTHHHHHHHHTTCCGGG--------TCSTTCC-TTT-SCCCCCTTHHHHHHHHHHHHHHHHHHHHHHCCSCSSCCGGGS T ss_pred CHHHHHHHHHHhCCccCc--------ccCCCcc-ccc-CCccccccchHHHHHHHHHHHHHHHHHHHhCCCCCCcchhcC Confidence 345666666655442110 0111100 000 001123456789999999999999886543221112232211 Q NP_000836.2 436 TIDGKE-LLGYIRAVNFN------GSAGTPVTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQLHLKVEDMQWAH 506 (908) Q Consensus 436 ~~~~~~-l~~~l~~~~f~------G~~G~~v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~~~~~~~i~w~~ 506 (908) ..++.. +.+.|++.+|. |.+| .++||++|++...+.+++++..+ +...+++||.|+....++...+.|++ T Consensus 414 ~~~~~~~l~~~l~~~~f~~~~~~~g~tG-~i~fd~~g~r~~~~~i~~~~~~~~~~~~~~~vg~w~~~~~~~~~~~~w~~ 491 (503) T 5CNJ_A 414 PVNGRRLYKDFVLNVKFDAPFRPADTHN-EVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWAS 491 (503) T ss_dssp SCCHHHCCCCCGGGCEEECTTCCTTCCC-EEECCTTSCCCCEEEEEEEEECTTSCEEEEEEEEEESSEEECGGGSTTC- T ss_pred ccCHHHHHHHHHHhCeecCCCCCCCCCC-cEEeCCCCCCCCeEEEEEEEEcCCCceEEEEEEEEccCcEEccccceecC Confidence 123333 44667777887 5788 89999999998888888887432 12358999999976555445678875 No 31 >5FBK_A Extracellular calcium-sensing receptor; membrane protein, G-protein coupled receptor; HET: NAG, CSO, TCR; 2.1A {Homo sapiens} Probab=99.81 E-value=3.8e-25 Score=252.03 Aligned_cols=460 Identities=32% Similarity=0.552 Sum_probs=275.6 Template_Neff=10.500 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGE----------RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD 109 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~----------~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~ 109 (908) ...+++++||+++|.++... ....|+... ..+.....|++.|++++|+++++++|+++++++.|+++++ T Consensus 53 ~~~~~~i~Ig~l~p~~~~~~~~~~~~~~~~~~~~c~~~~-~~~~~~~~~~~~a~~~in~~~~~~~g~~i~~~~~D~~~~~ 131 (568) T 5FBK_A 53 AQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYN-FRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTV 131 (568) T ss_dssp EEECCSEEEEEEECSEEEECCCCCCCSSCCCCCCEEEEC-HHHHHHHHHHHHHHHHHHTCSSSSSSCCEEEEEEECTTCH T ss_pred eeecCCEEEEEeeeeeecccccCCCccCCCCcccceecc-cccHHHHHHHHHHHHHHhcCCCCCCCCEEeeEEEeCCCCH Confidence 45678999999999986431 123455422 2456788999999999999888888899999999988775 Q NP_000836.2 110 TYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRY 189 (908) Q Consensus 110 ~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~ 189 (908) ..+.+.+.+++.+- ..+.....+.+.+....++++++||+.++..+..++.++...++|+|++.+..+.+.+...+ T Consensus 132 ~~a~~~~~~l~~~~----~~~~~~~~~~~~~~~~~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~ 207 (568) T 5FBK_A 132 SKALEATLSFVAQN----KIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF 207 (568) T ss_dssp HHHHHHHHHHTHHH----HHHHHTHHHHSCCCSCCCCEEEEECCSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCTTTC T ss_pred HHHHHHHHHHHHhc----CcccCCccccccCCCCCCCeEEEEcCCCcHHHHHHHHHHhhhCCcEeccccCCcccCCcccC Confidence 54443333333210 00000000000011111357899998888777788888899999999988766555443357 Q NP_000836.2 190 DFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRL 269 (908) Q Consensus 190 ~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l 269 (908) ++++++.+++...+.++++++++++|++|++++.++.++....+.+++.+++. ++++.....+.......++...++++ T Consensus 208 ~~~~~~~~~~~~~~~a~~~~~~~~~~~~v~vi~~~~~~~~~~~~~~~~~~~~~-gi~v~~~~~~~~~~~~~~~~~~~~~l 286 (568) T 5FBK_A 208 KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEER-DICIDFSELISQYSDEEEIQHVVEVI 286 (568) T ss_dssp TTEEESSCCTHHHHHHHHHHHHHTTCCSEEEEEESSTTHHHHHHHHHHHHHHT-TCCEEEEEEECTTCCHHHHHHHHHHH T ss_pred CceeecCCCchHHHHHHHHHHHHcCCcEEEEEEecCccchhHHHHHHHHHHHC-CeEEEEEEeecCCCCHHHHHHHHHHH Confidence 88999999998889999999988999999999977778888888888888775 46665433222101223455667777 Q NP_000836.2 270 LETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPV-YQQEEIAEGAVTILPKRASIDGFDRYFRSR 348 (908) Q Consensus 270 ~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~-~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~ 348 (908) +. .++|+|++.+....+..+++++++.|+.. ..|++.+.|....... ........+.+.+.........|..|.... T Consensus 287 ~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~i~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~f~~~~~~~ 364 (568) T 5FBK_A 287 QN-STAKVIVVFSSGPDLEPLIKEIVRRNITG-KIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKV 364 (568) T ss_dssp HH-CCCCEEEEECCHHHHHHHHHHHHHTTCCS-CEEEECHHHHTCTTTCCGGGHHHHTTCEEEEECCBCCTTHHHHHHTC T ss_pred Hh-CCCeEEEEEcCchhHHHHHHHHHHcCCCC-CEEEEehhhcccccccCccceeeeceEEEEEeccccCccHHHHHHhc Confidence 63 57899888877777888999988888753 4566665443321100 000111223333332222233333333221 Q NP_000836.2 349 TLANNRRNVWFAEFWEENFGCKLGSHGK----------------------RNSHIKKCTGLERIAR----DSSYEQEGKV 402 (908) Q Consensus 349 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------------------~~~~~~~c~~~~~~~~----~~~~~~~~~~ 402 (908) .+.......++.++|++.+.|....... ...+...|+..+.... ........++ T Consensus 365 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~a 444 (568) T 5FBK_A 365 HPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRIS 444 (568) T ss_dssp CTTTCSSBTTHHHHHHHHHTCBC-------------------------------CCBCCSCCCGGGSCCTTTCCSCBSHH T ss_pred CCccCCCChhHHHHHHHHhCCccCCCCCCCCCchhcccCccccCCccCCCCcCCCCCCCCCCCcccCCCCcccccccchH Confidence 1111112223445555544442210000 0001112322111000 0001123567 Q NP_000836.2 403 QFVIDAVYSMAYALHNMHKDLCPG---YIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQIT 479 (908) Q Consensus 403 ~~~yDAv~~la~Al~~~~~~~~~~---~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~ 479 (908) .++||||+++++|++++....+.. ....|.......+..+.+.|++.+|.|.+|+.|+||++|+|...+.|++++.. T Consensus 445 ~~~yDaV~~~a~al~~~~~~~~~~~~~~~~~c~~~~~~~~~~l~~~l~~~~f~G~tG~~v~fd~~g~r~~~~~I~~~~~~ 524 (568) T 5FBK_A 445 YNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLS 524 (568) T ss_dssp HHHHHHHHHHHHHHHHHHTCCTTSSSSGGGCCCCGGGCCHHHHHHHHHTCEEECTTSCEEECCTTSCCCCCEEEEEEEEC T ss_pred HHHHHHHHHHHHHHHHHHhcCCCCCCCCCCCcccccccCHHHHHHHHhcCeeecCCCCEEEeCCCCCCCccEEEEEEEEc Confidence 899999999999999987543321 01223221122344577888888999988657999999999888999888743 Q NP_000836.2 480 N--KSTEYKVIGHWTNQL------HLKVEDMQWAHR 507 (908) Q Consensus 480 ~--~~~~~~~Vg~~~~~~------~~~~~~i~w~~~ 507 (908) . +...++.||.|+... .++...+.|.++ T Consensus 525 ~~~~~~~~~~vg~~~~~~~~~~~l~~~~~~i~w~~g 560 (568) T 5FBK_A 525 PEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGF 560 (568) T ss_dssp TTTCSEEEEEEEEECTTSCTTSSEEECGGGCCBTTT T ss_pred CCCCcEEEEEEEEEEccccCCCeEEEeccceeecCC Confidence 1 112588999998652 122335777654 No 32 >5FBK_B Extracellular calcium-sensing receptor; membrane protein, G-protein coupled receptor; HET: TCR, NAG, CSO; 2.1A {Homo sapiens} Probab=99.81 E-value=4.7e-25 Score=251.32 Aligned_cols=460 Identities=32% Similarity=0.552 Sum_probs=272.9 Template_Neff=10.500 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGE----------RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD 109 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~----------~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~ 109 (908) ....++++||+++|.++... ....|+... ..+.....|++.|++++|+++++++|+++++++.|+++++ T Consensus 53 ~~~~~~i~Ig~l~p~~~~~~~~~~~~~~~~~~~~c~~~~-~~~~~~~~~~~~a~~~in~~~~~~~g~~i~~~~~D~~~~~ 131 (568) T 5FBK_B 53 AQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYN-FRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTV 131 (568) T ss_dssp EEECCSEEEEEEECSEEEECCCCCCCSSCCCCCCEEEEC-HHHHHHHHHHHHHHHHHHTCSSSSSSCCEEEEEEECTTCH T ss_pred eeecCCEEEEEEeeeeecccccCCCccCCCCcccceecc-cchHHHHHHHHHHHHHHhcCCCCCCCCEEeEEEEeCCCCH Confidence 45678999999999986431 123455422 2456788999999999999888888899999999988775 Q NP_000836.2 110 TYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRY 189 (908) Q Consensus 110 ~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~ 189 (908) ..+.+.+.+++.+- +.+.....+.+.+....++++++||+.++..+..++.++...++|+|++.+..+.+.+...+ T Consensus 132 ~~a~~~~~~l~~~~----~~~~~~~~~~~~~~~~~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~ 207 (568) T 5FBK_B 132 SKALEATLSFVAQN----KIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF 207 (568) T ss_dssp HHHHHHHHHHTHHH----HHCC---------------EEEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTTC T ss_pred HHHHHHHHHHHHhc----CcccCCccccccCCCCCCCeEEEEcCCCcHHHHHHHHHHhhhCCcEeccccCCcccCCcccC Confidence 54443333333210 00000000000011111357899998888777788888999999999988766555443357 Q NP_000836.2 190 DFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRL 269 (908) Q Consensus 190 ~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l 269 (908) ++++++.+++...+.++++++++++|++|++++.++.++....+.+++.+++. ++++.....+.......++...++++ T Consensus 208 ~~~~~~~~~~~~~~~a~~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-gi~v~~~~~~~~~~~~~~~~~~~~~l 286 (568) T 5FBK_B 208 KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEER-DICIDFSELISQYSDEEEIQHVVEVI 286 (568) T ss_dssp TTEEESSCCHHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHT-TCEEEEEEEECTTCCHHHHHHHHHHH T ss_pred CceeecCCCcHHHHHHHHHHHHHcCCeEEEEEEeCCccchhHHHHHHHHHHHC-CeEEEEEEeecCCCCHHHHHHHHHHH Confidence 88999999998889999999988999999999977778888888888888775 46665433222101223455667777 Q NP_000836.2 270 LETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPV-YQQEEIAEGAVTILPKRASIDGFDRYFRSR 348 (908) Q Consensus 270 ~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~-~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~ 348 (908) +. .++|+|++.+....+..+++++++.|+.. ..|+..+.|....... ........+.+.+.........|..|.... T Consensus 287 ~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~i~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~f~~~~~~~ 364 (568) T 5FBK_B 287 QN-STAKVIVVFSSGPDLEPLIKEIVRRNITG-KIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKV 364 (568) T ss_dssp HH-CCCCEEEEECCHHHHHHHHHHHHHTTCCC-CEEEECHHHHTCTTTCCGGGHHHHTTCEEEEECCBCCTTHHHHHHTC T ss_pred Hh-CCCeEEEEecCchhHHHHHHHHHHcCCCC-CEEEEechhcccccccCccceeeeccEEEEEecCCcCchHHHHHHhc Confidence 63 57899888877777888999988888753 4566655443321100 000111223333322222233333332221 Q NP_000836.2 349 TLANNRRNVWFAEFWEENFGCKLGSHGK----------------------RNSHIKKCTGLERIAR----DSSYEQEGKV 402 (908) Q Consensus 349 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------------------~~~~~~~c~~~~~~~~----~~~~~~~~~~ 402 (908) .+.......++.++|++.+.|....... ...+...|+..+.... ........++ T Consensus 365 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~a 444 (568) T 5FBK_B 365 HPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRIS 444 (568) T ss_dssp CTTTCSSBTTHHHHHHHHHTCBCC-----------------------------CCCBCCSCCCGGGSCCTTTCCSCBSHH T ss_pred CCccCCCChhHHHHHHHHhCCccCCCCCCCCCchhcccCCcccCCccCCCCCCCCCCCCCCCCcccCCCCcccccccchH Confidence 1111112223445555544442210000 0001112322111000 0001123567 Q NP_000836.2 403 QFVIDAVYSMAYALHNMHKDLCPG---YIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQIT 479 (908) Q Consensus 403 ~~~yDAv~~la~Al~~~~~~~~~~---~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~ 479 (908) .++||||+++++|++++....+.. ....|.......+..+.+.|++.+|.|.+|+.|+||++|+|...+.|++++.. T Consensus 445 ~~~yDaV~~~a~al~~~~~~~~~~~~~~~~~c~~~~~~~~~~l~~~l~~~~f~G~tG~~v~f~~~G~r~~~~~I~~~~~~ 524 (568) T 5FBK_B 445 YNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLS 524 (568) T ss_dssp HHHHHHHHHHHHHHHHHHTCCTTSSSSGGGCCCCGGGCCHHHHHHHHHTCCEECTTSCEECCCTTSCCCCCEEEEEEEEC T ss_pred HHHHHHHHHHHHHHHHHHhcCCCCCCCCCCCcccccccCHHHHHHHHhhCeeecCCCCEEEeCCCCCCCCcEEEEEEEEc Confidence 899999999999999987543321 01223221122344577888888999988757999999999888999888743 Q NP_000836.2 480 N--KSTEYKVIGHWTNQL------HLKVEDMQWAHR 507 (908) Q Consensus 480 ~--~~~~~~~Vg~~~~~~------~~~~~~i~w~~~ 507 (908) . +...++.||.|+... .++...+.|.++ T Consensus 525 ~~~~~~~~~~vg~~~~~~~~~~~l~~~~~~i~W~~g 560 (568) T 5FBK_B 525 PEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGF 560 (568) T ss_dssp TTTSSEEEEEEEEECTTSCTTSSEEECGGGCCCC-- T ss_pred CCCCcEEEEEEEEEEeeccCCCeEEEeccceeccCC Confidence 1 112588999998652 122335778654 No 33 >1DP4_A ATRIAL NATRIURETIC PEPTIDE RECEPTOR A; periplasmic binding protein fold, dimer; HET: SO4, NAG; 2.0A {Rattus norvegicus} SCOP: c.93.1.1 Probab=99.79 E-value=2.8e-24 Score=236.57 Aligned_cols=369 Identities=15% Similarity=0.224 Sum_probs=238.8 Template_Neff=11.700 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-----SRDTYALEQSLT 118 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-----~~~~~a~~~~~~ 118 (908) ++++||+++|.++... ...+.....|+++|++++|+++++++|+++++++.|+. +++..+.+.+ T Consensus 1 ~~i~ig~~~p~~~~~~---------~~~~~~~~~~~~~A~~~in~~~~~~~~~~i~l~~~d~~~~~~~~~~~~~~~~~-- 69 (435) T 1DP4_A 1 SDLTVAVVLPLTNTSY---------PWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAA-- 69 (435) T ss_dssp CEEEEEEEECSSCCCS---------TTCHHHHHHHHHHHHHHHHTCTTSSTTCEEEEEEEECBCTTSSBCTTHHHHHH-- T ss_pred CCeEEEEEcccCCCCC---------CcchhhhHHHHHHHHHHHHcCCCCCCCcEEEEEEcCCccccccccccchHHHH-- Confidence 3689999999987431 01266788999999999999887777899999988875 4433322222 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++. .++++++||+.++..+..++.++...++|+|++.+.++.+.++..+++++++.|+ T Consensus 70 --~~~~~------------------~~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~~~p~ 129 (435) T 1DP4_A 70 --VDLKW------------------EHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPS 129 (435) T ss_dssp --HHHHH------------------HHCCSEEECCCSHHHHHHHHHHHHHHTCCEEESCCCCGGGGCTTTSTTEEECSCC T ss_pred --HHHHH------------------hcCCCEEECCCCcccchhHHHHHhhcCCCEEecCCchhccCccceeeeeeeeCCC Confidence 22222 1578899999888777888899999999999988877666544457899999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGES-----GVEAFTQISRE-IGGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~-----~~~~~~~~~~~-~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) ....+.++++++++++|+++++|+.++.++.. ..+.+.+.+++ . ++++.....+. .+..++...+++++. T Consensus 130 ~~~~~~a~~~~~~~~~~~~v~ii~~~~~~g~~~~~~~~~~~~~~~~~~~~-~~~v~~~~~~~--~~~~~~~~~~~~~~~- 205 (435) T 1DP4_A 130 HVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERL-NITVNHQEFVE--GDPDHYPKLLRAVRR- 205 (435) T ss_dssp HHHHHHHHHHHHHHHTCCSEEEEEEECCSSSCCHHHHHHHHHHHHHHHHH-CCEEEEEEECT--TCGGGHHHHHHHHHH- T ss_pred HHHHHHHHHHHHHHHCCeEEEEEEEcCCCCCCceehHHHHHHHHHHHHHc-CCeeceeeecC--CCcchHHHHHHHHHh- Confidence 99899999999988999999999876665533 45666666654 3 35554332222 122345566666652 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAP----------V------YQQEEIAEGAVTILPKR 335 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~----------~------~~~~~~~~g~~~~~~~~ 335 (908) ++++|++......+..+++++++.|+.. .+.|+..+.+...... . ........+.+.+.... T Consensus 206 -~~~~iv~~~~~~~~~~~l~~a~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 284 (435) T 1DP4_A 206 -KGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKE 284 (435) T ss_dssp -HCSEEEEESCHHHHHHHHHHHHHTTCCTTTCEEEEECTTCTTSCSSCTTSCBCTTCCSSSCHHHHHHHGGGEEEEEECC T ss_pred -cccEEEEeCCHHHHHHHHHHHHHCCCCCCCEEEEEEEcCCcccccccCCCCCCCCcCCCCCCHHHHHHHHhceecccCC Confidence 5788888877778889999999888853 4677765533221000 0 00000111111110000 Q NP_000836.2 336 ASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYA 415 (908) Q Consensus 336 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~A 415 (908) ...+....|.+.+++.+...+ .|... ...+..++..+|||+++++.| T Consensus 285 ---------------~~~~~~~~f~~~~~~~~~~~~-----------~~~~~-------~~~~~~~~~~~yda~~~~~~a 331 (435) T 1DP4_A 285 ---------------PDNPEYLEFLKQLKLLADKKF-----------NFTVE-------DGLKNIIPASFHDGLLLYVQA 331 (435) T ss_dssp ---------------CCSHHHHHHHHHHHHHHHHHH-----------CCCCC-------CSGGGHHHHHHHHHHHHHHHH T ss_pred ---------------CCCHHHHHHHHHHHHHhhcCC-----------CCCcc-------cccccccHHHHHHHHHHHHHH Confidence 000111112222222111000 01000 012345678899999999999 Q NP_000836.2 416 LHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 416 l~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ++++....+. ..++..+.+.|++..|.|.+| .+.|+++|++...+.+.+++.. .+.++.||.|+.. T Consensus 332 l~~~~~~~~~----------~~~~~~l~~~l~~~~f~g~~G-~~~f~~~g~~~~~~~i~~~~~~--~~~~~~vg~~~~~ 397 (435) T 1DP4_A 332 VTETLAQGGT----------VTDGENITQRMWNRSFQGVTG-YLKIDRNGDRDTDFSLWDMDPE--TGAFRVVLNYNGT 397 (435) T ss_dssp HHHHHHTTCC----------TTCHHHHHHTTTTEEEEETTE-EEEECTTSBBCCCEEEEEECTT--TCCEEEEEEECTT T ss_pred HHHHHHcCCC----------CCCHHHHHHHHhcceEeecCe-eEEECCCCCccccEEEEEEcCC--CCeEEEEEEEecC Confidence 9988643210 124456778888889999999 8999999998877888888742 2468899999865 No 34 >1DP4_C ATRIAL NATRIURETIC PEPTIDE RECEPTOR A; periplasmic binding protein fold, dimer; HET: NAG, SO4; 2.0A {Rattus norvegicus} SCOP: c.93.1.1 Probab=99.79 E-value=2.8e-24 Score=236.57 Aligned_cols=369 Identities=15% Similarity=0.224 Sum_probs=238.8 Template_Neff=11.700 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-----SRDTYALEQSLT 118 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-----~~~~~a~~~~~~ 118 (908) ++++||+++|.++... ...+.....|+++|++++|+++++++|+++++++.|+. +++..+.+.+ T Consensus 1 ~~i~ig~~~p~~~~~~---------~~~~~~~~~~~~~A~~~in~~~~~~~~~~i~l~~~d~~~~~~~~~~~~~~~~~-- 69 (435) T 1DP4_C 1 SDLTVAVVLPLTNTSY---------PWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAA-- 69 (435) T ss_dssp CEEEEEEEECSSCCCS---------TTCHHHHHHHHHHHHHHHHTCTTSSTTCEEEEEEEECBCTTSSBCTTHHHHHH-- T ss_pred CCeEEEEEcccCCCCC---------CcchhhhHHHHHHHHHHHHcCCCCCCCcEEEEEEcCCccccccccccchHHHH-- Confidence 3689999999987431 01266788999999999999887777899999988875 4433322222 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++. .++++++||+.++..+..++.++...++|+|++.+.++.+.++..+++++++.|+ T Consensus 70 --~~~~~------------------~~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~~~p~ 129 (435) T 1DP4_C 70 --VDLKW------------------EHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPS 129 (435) T ss_dssp --HHHHH------------------HHCCSEEECCCSHHHHHHHHHHHHHHTCCEEESCCCCGGGGCTTTSTTEEECSCC T ss_pred --HHHHH------------------hcCCCEEECCCCcccchhHHHHHhhcCCCEEecCCchhccCccceeeeeeeeCCC Confidence 22222 1578899999888777888899999999999988877666544457899999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGES-----GVEAFTQISRE-IGGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~-----~~~~~~~~~~~-~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) ....+.++++++++++|+++++|+.++.++.. ..+.+.+.+++ . ++++.....+. .+..++...+++++. T Consensus 130 ~~~~~~a~~~~~~~~~~~~v~ii~~~~~~g~~~~~~~~~~~~~~~~~~~~-~~~v~~~~~~~--~~~~~~~~~~~~~~~- 205 (435) T 1DP4_C 130 HVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERL-NITVNHQEFVE--GDPDHYPKLLRAVRR- 205 (435) T ss_dssp HHHHHHHHHHHHHHHTCCSEEEEEEECCSSSCCHHHHHHHHHHHHHHHHH-CCEEEEEEECT--TCGGGHHHHHHHHHH- T ss_pred HHHHHHHHHHHHHHHCCeEEEEEEEcCCCCCCceehHHHHHHHHHHHHHc-CCeeceeeecC--CCcchHHHHHHHHHh- Confidence 99899999999988999999999876665533 45666666654 3 35554332222 122345566666652 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAP----------V------YQQEEIAEGAVTILPKR 335 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~----------~------~~~~~~~~g~~~~~~~~ 335 (908) ++++|++......+..+++++++.|+.. .+.|+..+.+...... . ........+.+.+.... T Consensus 206 -~~~~iv~~~~~~~~~~~l~~a~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 284 (435) T 1DP4_C 206 -KGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKE 284 (435) T ss_dssp -HCSEEEEESCHHHHHHHHHHHHHTTCCTTTCEEEEECTTCTTSCSSCTTSCBCTTCCSSSCHHHHHHHGGGEEEEEECC T ss_pred -cccEEEEeCCHHHHHHHHHHHHHCCCCCCCEEEEEEEcCCcccccccCCCCCCCCcCCCCCCHHHHHHHHhceecccCC Confidence 5788888877778889999999888853 4677765533221000 0 00000111111110000 Q NP_000836.2 336 ASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYA 415 (908) Q Consensus 336 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~A 415 (908) ...+....|.+.+++.+...+ .|... ...+..++..+|||+++++.| T Consensus 285 ---------------~~~~~~~~f~~~~~~~~~~~~-----------~~~~~-------~~~~~~~~~~~yda~~~~~~a 331 (435) T 1DP4_C 285 ---------------PDNPEYLEFLKQLKLLADKKF-----------NFTVE-------DGLKNIIPASFHDGLLLYVQA 331 (435) T ss_dssp ---------------CCSHHHHHHHHHHHHHHHHHH-----------CCCCC-------CSGGGHHHHHHHHHHHHHHHH T ss_pred ---------------CCCHHHHHHHHHHHHHhhcCC-----------CCCcc-------cccccccHHHHHHHHHHHHHH Confidence 000111112222222111000 01000 012345678899999999999 Q NP_000836.2 416 LHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 416 l~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ++++....+. ..++..+.+.|++..|.|.+| .+.|+++|++...+.+.+++.. .+.++.||.|+.. T Consensus 332 l~~~~~~~~~----------~~~~~~l~~~l~~~~f~g~~G-~~~f~~~g~~~~~~~i~~~~~~--~~~~~~vg~~~~~ 397 (435) T 1DP4_C 332 VTETLAQGGT----------VTDGENITQRMWNRSFQGVTG-YLKIDRNGDRDTDFSLWDMDPE--TGAFRVVLNYNGT 397 (435) T ss_dssp HHHHHHTTCC----------TTCHHHHHHTTTTEEEEETTE-EEEECTTSBBCCCEEEEEECTT--TCCEEEEEEECTT T ss_pred HHHHHHcCCC----------CCCHHHHHHHHhcceEeecCe-eEEECCCCCccccEEEEEEcCC--CCeEEEEEEEecC Confidence 9988643210 124456778888889999999 8999999998877888888742 2468899999865 No 35 >5X2M_A Taste receptor, type 1, member; receptor, ligand binding, amino acid; HET: GLN, NAG; 2.206A {Oryzias latipes} Probab=99.78 E-value=4.3e-24 Score=237.04 Aligned_cols=419 Identities=24% Similarity=0.397 Sum_probs=256.0 Template_Neff=11.300 Q NP_000836.2 35 EYAHSIRVDGDIILGGLFPVHAKGE------RGVPCGE-LKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCS 107 (908) Q Consensus 35 ~~~~~~~~~~~i~Ig~l~p~~~~~~------~~~~c~~-~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~ 107 (908) ..+.....+++++||+++|+++... ....|+. .....+.....|+++|++++|+++++++|+++++.+.|++. T Consensus 4 ~~~~~~~~~~~i~ig~l~p~~~~~~~~~~~~~~~~c~~~~~~~~g~~~~~a~~~A~~~iN~~~~~~~~~~i~~~~~d~~~ 83 (461) T 5X2M_A 4 DQTSEFHLRGDYLIGGLFNIHYVAAANFQRPQAIDCSSKLFILPNYRRFQMMRFSVEEINNSSSLLPNVSLGYQMFDHCS 83 (461) T ss_dssp --CBTTEECCSEEEEEEECCEECCCCCCSSCBCCCGGGSEECHHHHHHHHHHHHHHHHHHTCSSSSTTCCEEEEEEECSC T ss_pred ccceeeEecCCEEEEeEEEeeecccccCCCCCCcccccceecchhHHHHHHHHHHHHHHHcCCCCCCCCcceEEEEcCCC Confidence 3455678889999999999997632 1234553 11235667889999999999998878788999999999876 Q NP_000836.2 108 RDTYALEQ-SLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN 186 (908) Q Consensus 108 ~~~~a~~~-~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~ 186 (908) +...+... .....++++.. ...+....++++++||+.++.....++.++...++|+|++.+..+.+.+. T Consensus 84 ~~~~~~~~~~~~~~~~l~~~----------~~~~~~~~~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~ 153 (461) T 5X2M_A 84 DIHSFPGIFKLLSVNDLIRP----------WEDASTGLPNAIGVVGPFTSTHALSIAPIFMTNLFPMVSYGCSGSVFSKE 153 (461) T ss_dssp STTCHHHHHHHHCSSSEECT----------TCC----CCSCSEEECCSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCT T ss_pred CcchHHHHHHHHhcCCcCCc----------ccccCCCCCCeeEEECCCCcHHHHHHHHHHhhcCCCeecceecCcccCCc Confidence 54321110 01111222110 00000001478899999888777788888999999999988766555443 Q NP_000836.2 187 TRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKII 266 (908) Q Consensus 187 ~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~ 266 (908) ..+++++++.++....+.++++++++++|+++++++.++.++....+.+++.+++. ++++.....++ . ..++...+ T Consensus 154 ~~~~~~~~~~~~~~~~~~a~~~~l~~~~~~~v~vi~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~-~~~~~~~~ 229 (461) T 5X2M_A 154 NLYPSFLRTVHSNKDVINAIVGIILNFNWRWVAFLYSDDDFGKDGLEQFKNKIEDS-EICLAFYKAIN--V-NTDYLQVF 229 (461) T ss_dssp TTSTTEEESSCCHHHHHHHHHHHHHHSSBCEEEEEEESSHHHHHHHHHHHHHHTTS-SCEEEEEEEEC--T-TCCHHHHH T ss_pred ccCCceeeecCCCHHHHHHHHHHHHHcCCcEEEEEEeCChhhHHHHHHHHHHHHhc-CcEEEEEEeeC--C-CccHHHHH Confidence 35788999999999999999999988999999999987778888888888887775 46665433332 1 23466677 Q NP_000836.2 267 KRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVY-QQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 267 ~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~-~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) ++++. .++++|++......+..+++++++.|+. .+.|+..+.|........ .......+.+.+.......+.+..++ T Consensus 230 ~~i~~-~~~~~iv~~~~~~~~~~~l~~~~~~g~~-~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 307 (461) T 5X2M_A 230 KQIEE-QNIKVIVVFAPKVYAEAVVESAVQLNVT-NKVWIADDGWSLNKKLPSMNGIQNIGTVLGVAQPVVTIPGFTDFI 307 (461) T ss_dssp HHHHH-TTCCEEEEECCHHHHHHHHHHHHHTTCC-SEEEEECTTTTTCSSGGGSTTGGGGEEEEEEECCCCCCTTHHHHH T ss_pred HHHHh-CCCeEEEEECChHHHHHHHHHHHHcCCC-CcEEEEechhhcCCccccCCccceeccEEEEeccceeCCCHHHHH Confidence 77763 5789988887777788999999988875 356666554432211000 00011122222211111111122111 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) ............+..++++..+.|. .... .. .......++..+|||++++++|++++..+.. T Consensus 308 ~~~~~~~~~~~~~~~~~~~~~~~~~---------------~~~~-~~-~~~~~~~~~~~~yDav~~~a~a~~~~~~~~~- 369 (461) T 5X2M_A 308 YSAISQTDGGDTEQKMFCNQKCNCS---------------NLSV-KS-LLNADPSFSFPVYAAVYAIAHALHNTLRCGS- 369 (461) T ss_dssp HHHHTC---------CCTTCCCCCT---------------TCCH-HH-HHTSCCTTHHHHHHHHHHHHHHHHHHHTCCS- T ss_pred HhcccccCCCChhHHHHhcccCCCC---------------cccc-hh-hccCCCccHHHHHHHHHHHHHHHHHHhhcCC- Confidence 1000000000111111111111110 0000 00 0011234678899999999999998864321 Q NP_000836.2 426 GYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 426 ~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ..|......++..+.+.|++..|.|.+| .+.|+++|++. ..+.+++++. ++.++.||.|+.. T Consensus 370 ---~~~~~~~~~~~~~l~~~l~~~~f~g~~G-~i~f~~~g~~~~~~~~i~~~~~---~~~~~~vg~~~~~ 432 (461) T 5X2M_A 370 ---DRCPKNITVHPHMILEELKKSNFTLLNQ-TVQFDENGDPKFGSLSVVFWNS---SGNAEEVGSYHFQ 432 (461) T ss_dssp ---SCCCCSCCCCHHHHHHHHHTCCEEETTE-EECBCTTSCBSCCCEEEEEECT---TSCEEEEEEECSS T ss_pred ---CCCCccCCCCHHHHHHHHhcCcEEeCCc-eEEECCCCCCCCccEEEEEEeC---CCCEEEEEEEEcC Confidence 1121111234556778888889999988 89999999886 6788888873 2478899999865 No 36 >5X2N_C Taste receptor, type 1, member; receptor, ligand binding, amino acid; HET: ALA, NAG; 2.2A {Oryzias latipes} Probab=99.78 E-value=4.3e-24 Score=237.04 Aligned_cols=419 Identities=24% Similarity=0.397 Sum_probs=256.5 Template_Neff=11.300 Q NP_000836.2 35 EYAHSIRVDGDIILGGLFPVHAKGE------RGVPCGE-LKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCS 107 (908) Q Consensus 35 ~~~~~~~~~~~i~Ig~l~p~~~~~~------~~~~c~~-~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~ 107 (908) ..+.....+++++||+++|+++... ....|+. .....+.....|+++|++++|+++++++|+++++.+.|++. T Consensus 4 ~~~~~~~~~~~i~ig~l~p~~~~~~~~~~~~~~~~c~~~~~~~~g~~~~~a~~~A~~~iN~~~~~~~~~~i~~~~~d~~~ 83 (461) T 5X2N_C 4 DQTSEFHLRGDYLIGGLFNIHYVAAANFQRPQAIDCSSKLFILPNYRRFQMMRFSVEEINNSSSLLPNVSLGYQMFDHCS 83 (461) T ss_dssp --CCTTEECCSEEEEEEECCEECCCCCCSSSBCCCGGGSEECHHHHHHHHHHHHHHHHHHHCSSSSTTCCEEEEEEECSC T ss_pred ccceeeEecCCEEEEeEEEeeecccccCCCCCCcccccceecchhHHHHHHHHHHHHHHHcCCCCCCCCcceEEEEcCCC Confidence 3455678889999999999997632 1234553 11235667889999999999998878788999999999876 Q NP_000836.2 108 RDTYALEQ-SLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN 186 (908) Q Consensus 108 ~~~~a~~~-~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~ 186 (908) +...+... .....++++.. ...+....++++++||+.++.....++.++...++|+|++.+..+.+.+. T Consensus 84 ~~~~~~~~~~~~~~~~l~~~----------~~~~~~~~~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~ 153 (461) T 5X2N_C 84 DIHSFPGIFKLLSVNDLIRP----------WEDASTGLPNAIGVVGPFTSTHALSIAPIFMTNLFPMVSYGCSGSVFSKE 153 (461) T ss_dssp GGGCHHHHHHHHCBTTEECT----------TCC-CCCCCSCSEEECCSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCT T ss_pred CcchHHHHHHHHhcCCcCCc----------ccccCCCCCCeeEEECCCCcHHHHHHHHHHhhcCCCeecceecCcccCCc Confidence 54321110 01111222110 00000001478899999888777788888999999999988766555443 Q NP_000836.2 187 TRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKII 266 (908) Q Consensus 187 ~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~ 266 (908) ..+++++++.++....+.++++++++++|+++++++.++.++....+.+++.+++. ++++.....++ . ..++...+ T Consensus 154 ~~~~~~~~~~~~~~~~~~a~~~~l~~~~~~~v~vi~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~-~~~~~~~~ 229 (461) T 5X2N_C 154 NLYPSFLRTVHSNKDVINAIVGIILNFNWRWVAFLYSDDDFGKDGLEQFKNKIEDS-EICLAFYKAIN--V-NTDYLQVF 229 (461) T ss_dssp TTCTTEEESSCCHHHHHHHHHHHHHTSSBCEEEEEEESSHHHHHHHHHHHHHHTTS-SCEEEEEEEEC--T-TCCHHHHH T ss_pred ccCCceeeecCCCHHHHHHHHHHHHHcCCcEEEEEEeCChhhHHHHHHHHHHHHhc-CcEEEEEEeeC--C-CccHHHHH Confidence 35788999999999999999999988999999999987778888888888887775 46665433332 1 23466677 Q NP_000836.2 267 KRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVY-QQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 267 ~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~-~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) ++++. .++++|++......+..+++++++.|+. .+.|+..+.|........ .......+.+.+.......+.+..++ T Consensus 230 ~~i~~-~~~~~iv~~~~~~~~~~~l~~~~~~g~~-~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 307 (461) T 5X2N_C 230 KQIEE-QNIKVIVVFAPKVYAEAVVESAVQLNVT-NKVWIADDGWSLNKKLPSMNGIQNIGTVLGVAQPVVTIPGFTDFI 307 (461) T ss_dssp HHHHH-TTCCEEEEECCHHHHHHHHHHHHHTTCC-SEEEEECTTTTTCSSGGGSTTGGGGEEEEEEECCCCCCTTHHHHH T ss_pred HHHHh-CCCeEEEEECChHHHHHHHHHHHHcCCC-CcEEEEechhhcCCccccCCccceeccEEEEeccceeCCCHHHHH Confidence 77763 5789988887777788999999988875 356666554432211000 00011122222211111111122111 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) ............+..++++..+.|. .... .. .......++..+|||++++++|++++..+.. T Consensus 308 ~~~~~~~~~~~~~~~~~~~~~~~~~---------------~~~~-~~-~~~~~~~~~~~~yDav~~~a~a~~~~~~~~~- 369 (461) T 5X2N_C 308 YSAISQTDGGDTEQKMFCNQKCNCS---------------NLSV-KS-LLNADPSFSFPVYAAVYAIAHALHNTLRCGS- 369 (461) T ss_dssp HHHHCC-------CCCCTTCCCCCC---------------SCCH-HH-HHTSCCTTHHHHHHHHHHHHHHHHHHTTCCS- T ss_pred HhcccccCCCChhHHHHhcccCCCC---------------cccc-hh-hccCCCccHHHHHHHHHHHHHHHHHHhhcCC- Confidence 1000000000111111111111110 0000 00 0011234678899999999999998864321 Q NP_000836.2 426 GYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 426 ~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ..|......++..+.+.|++..|.|.+| .+.|+++|++. ..+.+++++. ++.++.||.|+.. T Consensus 370 ---~~~~~~~~~~~~~l~~~l~~~~f~g~~G-~i~f~~~g~~~~~~~~i~~~~~---~~~~~~vg~~~~~ 432 (461) T 5X2N_C 370 ---DRCPKNITVHPHMILEELKKSNFTLLNQ-TVQFDENGDPKFGSLSVVFWNS---SGNAEEVGSYHFQ 432 (461) T ss_dssp ---SCCCSSCCCCHHHHHHHHHTCCEEETTE-EECBCTTSCBSCCCEEEEEECT---TSCEEEEEEECSS T ss_pred ---CCCCccCCCCHHHHHHHHhcCcEEeCCc-eEEECCCCCCCCccEEEEEEeC---CCCEEEEEEEEcC Confidence 1121111234556778888889999988 89999999886 6788888873 2478899999865 No 37 >5X2M_B Taste receptor, type 1, member; receptor, ligand binding, amino acid; HET: GLN, NAG; 2.206A {Oryzias latipes} Probab=99.76 E-value=1.5e-23 Score=233.83 Aligned_cols=440 Identities=23% Similarity=0.419 Sum_probs=263.9 Template_Neff=11.200 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGE---------RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD 109 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~---------~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~ 109 (908) .....++++||+++|.++... ....|+... ..+.....|+++|++++|+++++++|+++++++.|+++++ T Consensus 12 ~~~~~~~i~ig~l~p~~~~~~~~~~~~~~~~~~~c~~~~-~~~~~~~~a~~~a~~~~n~~~~~~~g~~i~~~~~d~~~~~ 90 (478) T 5X2M_B 12 LFSMPGDIKLGGLFPIKEQSNEVSNDLTKLNSVSCDSLN-KDGLGRALVMKYAVEEINANSQLLPGVKLGYKIYNTCRHS 90 (478) T ss_dssp SSEECCSEEEEEEECCEECC------------CCCCEEC-HHHHHHHHHHHHHHHHHHHCTTTSTTCCEEEEEEECTTCH T ss_pred ccccCCCEEEEEEEeccccCCcccccccccCCCcccccc-chhHHHHHHHHHHHHHHHcCCCCCCCCeeeEEEEccCCCH Confidence 356678999999999987532 123465432 3467788999999999999888877899999999988775 Q NP_000836.2 110 TYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRY 189 (908) Q Consensus 110 ~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~ 189 (908) ..+.+.+.+++.+.... .... .+.....+++++++||+.++.....++.++...++|+|++....+.+.+...+ T Consensus 91 ~~~~~~~~~l~~~~~~~-~~~~-----~~~~~~~~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~ 164 (478) T 5X2M_B 91 AVIVRPALSFLTEKSNG-TLSV-----ECNYTDYETDMVAVIGPQSSEMVTVIGKLLGFFLMPQISFGATSDKFSDSLVY 164 (478) T ss_dssp HHHHHHHHHTTSBTTTS-SEEC-----CSBCTTCCBSCSEEECCSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCTTTS T ss_pred HHHHHHHHHHHhhccCC-cccc-----ccCCCCCCCCeEEEEcCCCHHHHHHHHHHHHhhCCcEeecCCCCcccCCCccc Confidence 54433333333210000 0000 00000001578899998888777778888899999999988766655443357 Q NP_000836.2 190 DFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE-PRPGEFEKIIKR 268 (908) Q Consensus 190 ~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~-~~~~~~~~~~~~ 268 (908) ++++++.++....+.++++++++++|++|++|+.++.++....+.+++.+++. ++++.....+... ....++...+++ T Consensus 165 ~~~~~~~~~~~~~~~al~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~ 243 (478) T 5X2M_B 165 PSFFRTVPSDIRQVDAMVQLIKKFNWNWVAVVGSEEEYGQQGVQQFSKKAEDM-GVCVAYQGLIPIYDDPKPAIQTIINN 243 (478) T ss_dssp TTEEESSCCHHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEECSSSCCHHHHHHHHHH T ss_pred cceeecCCCcHHHHHHHHHHHHHcCCeEEEEEecCCHHHHHHHHHHHHHHHHc-CcEEEEEeeecCCCCChHHHHHHHHH Confidence 89999999998899999999988999999999987778888888888888765 4555433222210 112345566677 Q NP_000836.2 269 LLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQ-QEEIAEGAVTILPKRASIDGFDRYFRS 347 (908) Q Consensus 269 l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~-~~~~~~g~~~~~~~~~~~~~~~~~~~~ 347 (908) ++. .++|+|++......+..+++++++.|+. ..|++.+.|......... ......+.+.+.........+ T Consensus 244 l~~-~~~~~ivl~~~~~~~~~~l~~~~~~g~~--~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~------ 314 (478) T 5X2M_B 244 IQT-TEVKVVVVFSLVSPAVSFFEEVIKKNLT--GVWIASSSWAISDKVYSLPNIDSIGTVIGFIDETETLELL------ 314 (478) T ss_dssp HHH-HTCSEEEEECCHHHHHHHHHHHHHTTCC--EEEEECTTTTTCHHHHTSTTGGGSEEEEEEEECCCCCTTH------ T ss_pred Hhc-CCCeEEEEEccChhHHHHHHHHHHcCCc--eeEEEecchhcccchhcCCCcccccceEEEEecccccccc------ Confidence 763 5788888877677788889999888874 356666544332110000 011112222211110000000 Q NP_000836.2 348 RTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARD-----SSYEQEGKVQFVIDAVYSMAYALHNMHKD 422 (908) Q Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~-----~~~~~~~~~~~~yDAv~~la~Al~~~~~~ 422 (908) .+....|.+.+.+.+...... .....|......... .......++..+|||++++++|+++.... T Consensus 315 -----~~~~~~f~~~~~~~~~~~~~~-----~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ydav~~~a~al~~~~~~ 384 (478) T 5X2M_B 315 -----SPFTEVLFKKIHEASPTEKPE-----DPYNPCPECWSLSPANVSLVKEESVQRTAFSVYAAVYTVAHALHKLLEC 384 (478) T ss_dssp -----HHHHHHHHHHHHHTTTC-----------CCSCGGGGGCCGGGGHHHHSHHHHTTHHHHHHHHHHHHHHHHHHTTC T ss_pred -----cHHHHHHHHHHHHcCCCCCCC-----CCCCCCCCccccCCCCcccccccccchHHHHHHHHHHHHHHHHHHHhcC Confidence 000111111111111100000 000011110000000 00123456778999999999999988753 Q NP_000836.2 423 LCPGYIGLCPRM--STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQL-HLKV 499 (908) Q Consensus 423 ~~~~~~~~~~~~--~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~-~~~~ 499 (908) .+. .|... ...+++.+.+.|++.+|.|.+| .+.||++|++...+.+++++.. ++.++.||.|+... .++. T Consensus 385 ~~~----~c~~~~~~~~~~~~l~~~l~~~~~~g~~G-~v~fd~~g~~~~~~~i~~~~~~--~~~~~~vg~~~~~~l~~~~ 457 (478) T 5X2M_B 385 NSA----ACKWSSSTRLYPWKLLEVLKEFSVNISNT-SLKFDQNGNPNIGYSVIQRIWE--NQSLSSVGSYRSANLSINE 457 (478) T ss_dssp CSS----CCSCCTTCCCCHHHHHHHHTTCEEEETTE-EEEBCTTSCBSCCEEEEEEETT--TTEEEEEEEEETTEEEECG T ss_pred CCC----cCCcccccCCCHHHHHHHHHhCeEecCCC-eEEECCCCCCCCceEEEEEEeC--CCeeEEEEEEecccceEec Confidence 321 12110 1134556778888888999888 8999999998888888887642 25789999998652 3333 Q NP_000836.2 500 EDMQWAHREHTHP 512 (908) Q Consensus 500 ~~i~w~~~~~~~p 512 (908) ..+.|.++...+| T Consensus 458 ~~~~w~~~~~~~p 470 (478) T 5X2M_B 458 TLFKWYTNNSEKP 470 (478) T ss_dssp GGCCCCSTTSSCC T ss_pred cceeeecCCCCCC Confidence 4577875433344 No 38 >5X2N_B Taste receptor, type 1, member; receptor, ligand binding, amino acid; HET: ALA, NAG; 2.2A {Oryzias latipes} Probab=99.76 E-value=1.5e-23 Score=233.83 Aligned_cols=440 Identities=23% Similarity=0.419 Sum_probs=264.3 Template_Neff=11.200 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGE---------RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD 109 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~---------~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~ 109 (908) .....++++||+++|.++... ....|+... ..+.....|+++|++++|+++++++|+++++++.|+++++ T Consensus 12 ~~~~~~~i~ig~l~p~~~~~~~~~~~~~~~~~~~c~~~~-~~~~~~~~a~~~a~~~~n~~~~~~~g~~i~~~~~d~~~~~ 90 (478) T 5X2N_B 12 LFSMPGDIKLGGLFPIKEQSNEVSNDLTKLNSVSCDSLN-KDGLGRALVMKYAVEEINANSQLLPGVKLGYKIYNTCRHS 90 (478) T ss_dssp SSEECCSEEEEEEECCEECCC-----------CCCCEEC-HHHHHHHHHHHHHHHHHHHCTTTSTTCCEEEEEEECTTCH T ss_pred ccccCCCEEEEEEEeccccCCcccccccccCCCcccccc-chhHHHHHHHHHHHHHHHcCCCCCCCCeeeEEEEccCCCH Confidence 356678999999999987532 123465432 3467788999999999999888877899999999988775 Q NP_000836.2 110 TYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRY 189 (908) Q Consensus 110 ~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~ 189 (908) ..+.+.+.+++.+.... .... .+.....+++++++||+.++.....++.++...++|+|++....+.+.+...+ T Consensus 91 ~~~~~~~~~l~~~~~~~-~~~~-----~~~~~~~~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~ 164 (478) T 5X2N_B 91 AVIVRPALSFLTEKSNG-TLSV-----ECNYTDYETDMVAVIGPQSSEMVTVIGKLLGFFLMPQISFGATSDKFSDSLVY 164 (478) T ss_dssp HHHHHHHHHTTSBTTTS-SEEC-----CSBCTTCCBSCSEEECCSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCTTTS T ss_pred HHHHHHHHHHHhhccCC-cccc-----ccCCCCCCCCeEEEEcCCCHHHHHHHHHHHHhhCCcEeecCCCCcccCCCccc Confidence 54433333333210000 0000 00000001578899998888777778888899999999988766655443357 Q NP_000836.2 190 DFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE-PRPGEFEKIIKR 268 (908) Q Consensus 190 ~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~-~~~~~~~~~~~~ 268 (908) ++++++.++....+.++++++++++|++|++|+.++.++....+.+++.+++. ++++.....+... ....++...+++ T Consensus 165 ~~~~~~~~~~~~~~~al~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~ 243 (478) T 5X2N_B 165 PSFFRTVPSDIRQVDAMVQLIKKFNWNWVAVVGSEEEYGQQGVQQFSKKAEDM-GVCVAYQGLIPIYDDPKPAIQTIINN 243 (478) T ss_dssp TTEEESSCCHHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEECSSSCCHHHHHHHHHH T ss_pred cceeecCCCcHHHHHHHHHHHHHcCCeEEEEEecCCHHHHHHHHHHHHHHHHc-CcEEEEEeeecCCCCChHHHHHHHHH Confidence 89999999998899999999988999999999987778888888888888765 4555433222210 112345566677 Q NP_000836.2 269 LLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQ-QEEIAEGAVTILPKRASIDGFDRYFRS 347 (908) Q Consensus 269 l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~-~~~~~~g~~~~~~~~~~~~~~~~~~~~ 347 (908) ++. .++|+|++......+..+++++++.|+. ..|++.+.|......... ......+.+.+.........+ T Consensus 244 l~~-~~~~~ivl~~~~~~~~~~l~~~~~~g~~--~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~------ 314 (478) T 5X2N_B 244 IQT-TEVKVVVVFSLVSPAVSFFEEVIKKNLT--GVWIASSSWAISDKVYSLPNIDSIGTVIGFIDETETLELL------ 314 (478) T ss_dssp HHH-HTCSEEEEECCHHHHHHHHHHHHHTTCC--EEEEECTTTTTCHHHHTSTTGGGSEEEEEEEECCCCCTTH------ T ss_pred Hhc-CCCeEEEEEccChhHHHHHHHHHHcCCc--eeEEEecchhcccchhcCCCcccccceEEEEecccccccc------ Confidence 763 5788888877677788889999888874 356666544332110000 011112222211110000000 Q NP_000836.2 348 RTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARD-----SSYEQEGKVQFVIDAVYSMAYALHNMHKD 422 (908) Q Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~-----~~~~~~~~~~~~yDAv~~la~Al~~~~~~ 422 (908) .+....|.+.+.+.+...... .....|......... .......++..+|||++++++|+++.... T Consensus 315 -----~~~~~~f~~~~~~~~~~~~~~-----~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ydav~~~a~al~~~~~~ 384 (478) T 5X2N_B 315 -----SPFTEVLFKKIHEASPTEKPE-----DPYNPCPECWSLSPANVSLVKEESVQRTAFSVYAAVYTVAHALHKLLEC 384 (478) T ss_dssp -----HHHHHHHHHHHHHHTTSCCC------CTTCSCGGGGGCCGGGTHHHHSHHHHTTHHHHHHHHHHHHHHHHHHTTC T ss_pred -----cHHHHHHHHHHHHcCCCCCCC-----CCCCCCCCccccCCCCcccccccccchHHHHHHHHHHHHHHHHHHHhcC Confidence 000111111111111100000 000011110000000 00123456778999999999999988753 Q NP_000836.2 423 LCPGYIGLCPRM--STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQL-HLKV 499 (908) Q Consensus 423 ~~~~~~~~~~~~--~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~-~~~~ 499 (908) .+. .|... ...+++.+.+.|++.+|.|.+| .+.||++|++...+.+++++.. ++.++.||.|+... .++. T Consensus 385 ~~~----~c~~~~~~~~~~~~l~~~l~~~~~~g~~G-~v~fd~~g~~~~~~~i~~~~~~--~~~~~~vg~~~~~~l~~~~ 457 (478) T 5X2N_B 385 NSA----ACKWSSSTRLYPWKLLEVLKEFSVNISNT-SLKFDQNGNPNIGYSVIQRIWE--NQSLSSVGSYRSANLSINE 457 (478) T ss_dssp CSS----CCSCCTTCCCCHHHHHHHHTTCEEEETTE-EEEBCTTSCBSCCEEEEEEETT--TTEEEEEEEEETTEEEECG T ss_pred CCC----cCCcccccCCCHHHHHHHHHhCeEecCCC-eEEECCCCCCCCceEEEEEEeC--CCeeEEEEEEecccceEec Confidence 321 12110 1134556778888888999888 8999999998888888887642 25789999998652 3333 Q NP_000836.2 500 EDMQWAHREHTHP 512 (908) Q Consensus 500 ~~i~w~~~~~~~p 512 (908) ..+.|.++...+| T Consensus 458 ~~~~w~~~~~~~p 470 (478) T 5X2N_B 458 TLFKWYTNNSEKP 470 (478) T ss_dssp GGCCCCSTTSCCC T ss_pred cceeeecCCCCCC Confidence 4577875433344 No 39 >5X2N_D Taste receptor, type 1, member; receptor, ligand binding, amino acid; HET: NAG, ALA; 2.2A {Oryzias latipes} Probab=99.76 E-value=1.5e-23 Score=233.83 Aligned_cols=440 Identities=23% Similarity=0.419 Sum_probs=260.0 Template_Neff=11.200 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGE---------RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD 109 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~---------~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~ 109 (908) .....++++||+++|.++... ....|+... ..+.....|+++|++++|+++++++|+++++++.|+++++ T Consensus 12 ~~~~~~~i~ig~l~p~~~~~~~~~~~~~~~~~~~c~~~~-~~~~~~~~a~~~a~~~~n~~~~~~~g~~i~~~~~d~~~~~ 90 (478) T 5X2N_D 12 LFSMPGDIKLGGLFPIKEQSNEVSNDLTKLNSVSCDSLN-KDGLGRALVMKYAVEEINANSQLLPGVKLGYKIYNTCRHS 90 (478) T ss_dssp SSEECCSEEEEEEECCEECCC---------CCCCCCEEC-HHHHHHHHHHHHHHHHHHHCTTSSTTCCEEEEEEECTTCH T ss_pred ccccCCCEEEEEEEeccccCCcccccccccCCCcccccc-chhHHHHHHHHHHHHHHHcCCCCCCCCeeeEEEEccCCCH Confidence 356678999999999987532 123465432 3467788999999999999888877899999999988775 Q NP_000836.2 110 TYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRY 189 (908) Q Consensus 110 ~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~ 189 (908) ..+.+.+.+++.+.... .... .+.....+++++++||+.++.....++.++...++|+|++....+.+.+...+ T Consensus 91 ~~~~~~~~~l~~~~~~~-~~~~-----~~~~~~~~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~ 164 (478) T 5X2N_D 91 AVIVRPALSFLTEKSNG-TLSV-----ECNYTDYETDMVAVIGPQSSEMVTVIGKLLGFFLMPQISFGATSDKFSDSLVY 164 (478) T ss_dssp HHHHHHHHHTTSBTTTS-SEEC-----CSBCTTCCBSCSEEECCSCHHHHHHHHHHHHHTTCCEEESSCCCGGGGCTTTS T ss_pred HHHHHHHHHHHhhccCC-cccc-----ccCCCCCCCCeEEEEcCCCHHHHHHHHHHHHhhCCcEeecCCCCcccCCCccc Confidence 54433333333210000 0000 00000001578899998888777778888899999999988766655443357 Q NP_000836.2 190 DFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE-PRPGEFEKIIKR 268 (908) Q Consensus 190 ~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~-~~~~~~~~~~~~ 268 (908) ++++++.++....+.++++++++++|++|++|+.++.++....+.+++.+++. ++++.....+... ....++...+++ T Consensus 165 ~~~~~~~~~~~~~~~al~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~ 243 (478) T 5X2N_D 165 PSFFRTVPSDIRQVDAMVQLIKKFNWNWVAVVGSEEEYGQQGVQQFSKKAEDM-GVCVAYQGLIPIYDDPKPAIQTIINN 243 (478) T ss_dssp TTEEESSCCHHHHHHHHHHHHTTTTCCCEEEEEESSHHHHHHHHHHHHHHTTT-TCCEEEEEEECSSSCCHHHHHHHHHH T ss_pred cceeecCCCcHHHHHHHHHHHHHcCCeEEEEEecCCHHHHHHHHHHHHHHHHc-CcEEEEEeeecCCCCChHHHHHHHHH Confidence 89999999998899999999988999999999987778888888888888765 4555433222210 112345566677 Q NP_000836.2 269 LLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQ-QEEIAEGAVTILPKRASIDGFDRYFRS 347 (908) Q Consensus 269 l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~-~~~~~~g~~~~~~~~~~~~~~~~~~~~ 347 (908) ++. .++|+|++......+..+++++++.|+. ..|++.+.|......... ......+.+.+.........+ T Consensus 244 l~~-~~~~~ivl~~~~~~~~~~l~~~~~~g~~--~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~------ 314 (478) T 5X2N_D 244 IQT-TEVKVVVVFSLVSPAVSFFEEVIKKNLT--GVWIASSSWAISDKVYSLPNIDSIGTVIGFIDETETLELL------ 314 (478) T ss_dssp HHC-----CEEEECCHHHHHHHHHHHHHTTCC--EEEEECHHHHTCHHHHTSTTGGGGEEEEEEEECCCCCTTH------ T ss_pred Hhc-CCCeEEEEEccChhHHHHHHHHHHcCCc--eeEEEecchhcccchhcCCCcccccceEEEEecccccccc------ Confidence 763 5788888877677788889999888874 356666544332110000 011112222211110000000 Q NP_000836.2 348 RTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARD-----SSYEQEGKVQFVIDAVYSMAYALHNMHKD 422 (908) Q Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~-----~~~~~~~~~~~~yDAv~~la~Al~~~~~~ 422 (908) .+....|.+.+.+.+...... .....|......... .......++..+|||++++++|+++.... T Consensus 315 -----~~~~~~f~~~~~~~~~~~~~~-----~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ydav~~~a~al~~~~~~ 384 (478) T 5X2N_D 315 -----SPFTEVLFKKIHEASPTEKPE-----DPYNPCPECWSLSPANVSLVKEESVQRTAFSVYAAVYTVAHALHKLLEC 384 (478) T ss_dssp -----HHHHHHHHHHHHTC------------CTTCSCGGGGGCCGGGTHHHHSHHHHTTHHHHHHHHHHHHHHHHHHTTC T ss_pred -----cHHHHHHHHHHHHcCCCCCCC-----CCCCCCCCccccCCCCcccccccccchHHHHHHHHHHHHHHHHHHHhcC Confidence 000111111111111100000 000011110000000 00123456778999999999999988753 Q NP_000836.2 423 LCPGYIGLCPRM--STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQL-HLKV 499 (908) Q Consensus 423 ~~~~~~~~~~~~--~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~-~~~~ 499 (908) .+. .|... ...+++.+.+.|++.+|.|.+| .+.||++|++...+.+++++.. ++.++.||.|+... .++. T Consensus 385 ~~~----~c~~~~~~~~~~~~l~~~l~~~~~~g~~G-~v~fd~~g~~~~~~~i~~~~~~--~~~~~~vg~~~~~~l~~~~ 457 (478) T 5X2N_D 385 NSA----ACKWSSSTRLYPWKLLEVLKEFSVNISNT-SLKFDQNGNPNIGYSVIQRIWE--NQSLSSVGSYRSANLSINE 457 (478) T ss_dssp CSS----CCSCCTTCCCCHHHHHHHHTTCEEEETTE-EEEBCTTSCBSCCEEEEEEETT--TTEEEEEEEEETTEEEECG T ss_pred CCC----cCCcccccCCCHHHHHHHHHhCeEecCCC-eEEECCCCCCCCceEEEEEEeC--CCeeEEEEEEecccceEec Confidence 321 12110 1134556778888888999888 8999999998888888887642 25789999998652 3333 Q NP_000836.2 500 EDMQWAHREHTHP 512 (908) Q Consensus 500 ~~i~w~~~~~~~p 512 (908) ..+.|.++...+| T Consensus 458 ~~~~w~~~~~~~p 470 (478) T 5X2N_D 458 TLFKWYTNNSEKP 470 (478) T ss_dssp GGCCCTTSCC--- T ss_pred cceeeecCCCCCC Confidence 4577875433344 No 40 >1JDN_A ATRIAL NATRIURETIC PEPTIDE CLEARANCE RECEPTOR; Natriuretic peptide receptor, dimer, allosteric; HET: NDG, BMA, FUC, MAN, NAG; 2.9A {Homo sapiens} SCOP: c.93.1.1 Probab=99.76 E-value=2e-23 Score=230.14 Aligned_cols=372 Identities=17% Similarity=0.238 Sum_probs=238.1 Template_Neff=11.600 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPD----LLSNITLGVRILDTCSRDTYALEQS 116 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~----il~g~~l~~~~~d~~~~~~~a~~~~ 116 (908) ...++++||+++|.++... ..+.....|++.|++++|++++ +++|.++++.+.|+++++.. + T Consensus 5 ~~~~~i~Igv~~p~~~~~~----------~~~~~~~~~~~~a~~~~n~~~g~~~~~~~~~~i~~~~~d~~~~~~~----~ 70 (441) T 1JDN_A 5 LPPQKIEVLVLLPQDDSYL----------FSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRA----L 70 (441) T ss_dssp --CCCEEEEEEECSCTTST----------TCHHHHHHHHHHHHHHHTC-------CCSSCCEEEEEEECTTSHHH----H T ss_pred CCCCeEEEEEEccCCCCCC----------CcHHHHHHHHHHHHHHHhccCCCCcCCCCCCEEEEEEecCCCChHH----H Confidence 4567899999999987531 2456788999999999998764 35688899998888776432 2 Q NP_000836.2 117 LTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN-TRYDFFSRV 195 (908) Q Consensus 117 ~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~-~~~~~~~~~ 195 (908) .+.++++... ..++++++||+.++..+..++.++...++|+|++.+..+.+... ..+++++++ T Consensus 71 ~~~~~~l~~~----------------~~~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~ 134 (441) T 1JDN_A 71 FSLVDRVAAA----------------RGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRV 134 (441) T ss_dssp HHHHHHHHHT----------------TTCCCSEEECCCSHHHHHHHHHHHHHTTCCEEESCCCSGGGGCCSSTTTTEEEC T ss_pred HHHHHHHHHH----------------hCCCCCEEECCCCHHhHHHHHHHHhhcCCcEEEecccchhhccchhhcccceee Confidence 2233322210 01578999998888777788888999999999988766655443 346889999 Q NP_000836.2 196 VPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESG---VEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~---~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) .++....++++++++++++|+++++++.++.++... .+.+++.+++. ++++... .+.. .+..++...+++++. T Consensus 135 ~~~~~~~~~~~~~~l~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~~~~-g~~v~~~-~~~~-~~~~~~~~~~~~i~~- 210 (441) T 1JDN_A 135 APAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEE-GLHTSIY-SFDE-TKDLDLEDIVRNIQA- 210 (441) T ss_dssp SCCTHHHHHHHHHHHHHTTCCEEEEEEECCSSSCHHHHHHHHHHHHHHHH-TCEEEEE-EECT-TSCCCHHHHHHHHHT- T ss_pred ccCHHHHHHHHHHHHHHcCCeEEEEEEeCCcccceeeEEhhHHHHHHHHc-CCeeEEE-eccC-CCCCCHHHHHHHHHh- Confidence 999999999999999888999999999877766655 67777777765 4665532 2211 123456667777763 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSK-----IAPV-----YQQEEIAEGAVTILPKRASIDGF 341 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~-----~~~~-----~~~~~~~~g~~~~~~~~~~~~~~ 341 (908) . +++|++......+..+++++++.|+.. .+.|+..+..... .... ........+.+...... T Consensus 211 ~-~~~vv~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~------ 283 (441) T 1JDN_A 211 S-ERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLR------ 283 (441) T ss_dssp T-CSEEEEECCHHHHHHHHHHHHHTTCTTSSSEEEEECGGGCGGGCCSCCCCSSTTHHHHHHHGGGEEEEEECC------ T ss_pred c-CcEEEEEcCHHHHHHHHHHHHHCCCCCCCEEEEEEeccCccccCCCCccCCCcCcHHHHHHHHHcchhcccC------ Confidence 3 788888777777888899998888754 3667665421110 0000 00000111111111000 Q NP_000836.2 342 DRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHK 421 (908) Q Consensus 342 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~ 421 (908) ...+....|.+.+++.+... . ..| ...+..++..+|||++++++|+++... T Consensus 284 ---------~~~~~~~~f~~~~~~~~~~~-~---------~~~----------~~~~~~~~~~~yDav~~~~~a~~~~~~ 334 (441) T 1JDN_A 284 ---------TVKPEFEKFSMEVKSSVEKQ-G---------LNM----------EDYVNMFVEGFHDAILLYVLALHEVLR 334 (441) T ss_dssp ---------CCCHHHHHHHHHHHHHHHHT-T---------CCC----------SCSCCHHHHHHHHHHHHHHHHHHHHHT T ss_pred ---------CCChhHHHHHHHHHHHHHhc-C---------CCc----------cccchhHHHHHHHHHHHHHHHHHHHHH Confidence 00011111222222111100 0 000 012345678899999999999999865 Q NP_000836.2 422 DLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 422 ~~~~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ..+. ..++..+.+.|++..|.|.+| .+.|+++|++...+.+++++..+ ++.++.||.|+.. T Consensus 335 ~~~~----------~~~~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~i~~~~~~~-~g~~~~vg~~~~~ 395 (441) T 1JDN_A 335 AGYS----------KKDGGKIIQQTWNRTFEGIAG-QVSIDANGDRYGDFSVIAMTDVE-AGTQEVIGDYFGK 395 (441) T ss_dssp TTCC----------TTCHHHHHHHHSSEEEEETTE-EEEECTTSBBCCEEEEEEEEETT-TTEEEEEEEEETT T ss_pred cCCC----------CCCHHHHHHHhhcCeEeecce-eEEECCCCCccceEEEEEeecCC-CCeEEEEEEEECC Confidence 3211 123456777888889999998 89999999887778888876321 3578899999864 No 41 >1JDP_A ATRIAL NATRIURETIC PEPTIDE CLEARANCE RECEPTOR; hormone-receptor complex, natriuretic peptide receptor; HET: NAG, NDG; 2.0A {Homo sapiens} SCOP: c.93.1.1 Probab=99.76 E-value=2e-23 Score=230.14 Aligned_cols=372 Identities=17% Similarity=0.238 Sum_probs=239.1 Template_Neff=11.600 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPD----LLSNITLGVRILDTCSRDTYALEQS 116 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~----il~g~~l~~~~~d~~~~~~~a~~~~ 116 (908) ...++++||+++|.++... ..+.....|++.|++++|++++ +++|.++++.+.|+++++.. + T Consensus 5 ~~~~~i~Igv~~p~~~~~~----------~~~~~~~~~~~~a~~~~n~~~g~~~~~~~~~~i~~~~~d~~~~~~~----~ 70 (441) T 1JDP_A 5 LPPQKIEVLVLLPQDDSYL----------FSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRA----L 70 (441) T ss_dssp CCCCEEEEEEEECSSTTST----------TCHHHHHHHHHHHHHHHCC-----CCSCTTCEEEEEEEECTTSTHH----H T ss_pred CCCCeEEEEEEccCCCCCC----------CcHHHHHHHHHHHHHHHhccCCCCcCCCCCCEEEEEEecCCCChHH----H Confidence 4567899999999987531 2456788999999999998764 35688899998888776432 2 Q NP_000836.2 117 LTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN-TRYDFFSRV 195 (908) Q Consensus 117 ~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~-~~~~~~~~~ 195 (908) .+.++++... ..++++++||+.++..+..++.++...++|+|++.+..+.+... ..+++++++ T Consensus 71 ~~~~~~l~~~----------------~~~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~ 134 (441) T 1JDP_A 71 FSLVDRVAAA----------------RGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRV 134 (441) T ss_dssp HHHHHHHHHT----------------TTCCCSEEECCCSHHHHHHHHHHHHHHTCCEEESCCCSGGGGCTTTTTTTEEEC T ss_pred HHHHHHHHHH----------------hCCCCCEEECCCCHHhHHHHHHHHhhcCCcEEEecccchhhccchhhcccceee Confidence 2233322210 01578999998888777788888999999999988766655443 346889999 Q NP_000836.2 196 VPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESG---VEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~---~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) .++....++++++++++++|+++++++.++.++... .+.+++.+++. ++++... .+.. .+..++...+++++. T Consensus 135 ~~~~~~~~~~~~~~l~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~~~~-g~~v~~~-~~~~-~~~~~~~~~~~~i~~- 210 (441) T 1JDP_A 135 APAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEE-GLHTSIY-SFDE-TKDLDLEDIVRNIQA- 210 (441) T ss_dssp SCCHHHHHHHHHHHHHHHTCCEEEEEEECCSSSCHHHHHHHHHHHHHHHH-TCEEEEE-EECT-TSCCCHHHHHHHHHH- T ss_pred ccCHHHHHHHHHHHHHHcCCeEEEEEEeCCcccceeeEEhhHHHHHHHHc-CCeeEEE-eccC-CCCCCHHHHHHHHHh- Confidence 999999999999999888999999999877766655 67777777765 4665532 2211 123456667777763 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSK-----IAPV-----YQQEEIAEGAVTILPKRASIDGF 341 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~-----~~~~-----~~~~~~~~g~~~~~~~~~~~~~~ 341 (908) . +++|++......+..+++++++.|+.. .+.|+..+..... .... ........+.+...... T Consensus 211 ~-~~~vv~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~------ 283 (441) T 1JDP_A 211 S-ERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLR------ 283 (441) T ss_dssp H-CSEEEEESCHHHHHHHHHHHHHTTCTTTTCEEEEECSSCCCSTTTCTTCCSSTTHHHHHHHGGGEEEEEECC------ T ss_pred c-CcEEEEEcCHHHHHHHHHHHHHCCCCCCCEEEEEEeccCccccCCCCccCCCcCcHHHHHHHHHcchhcccC------ Confidence 3 788888777777888899998888754 3667665421110 0000 00000111111111000 Q NP_000836.2 342 DRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHK 421 (908) Q Consensus 342 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~ 421 (908) ...+....|.+.+++.+... . ..| ...+..++..+|||++++++|+++... T Consensus 284 ---------~~~~~~~~f~~~~~~~~~~~-~---------~~~----------~~~~~~~~~~~yDav~~~~~a~~~~~~ 334 (441) T 1JDP_A 284 ---------TVKPEFEKFSMEVKSSVEKQ-G---------LNM----------EDYVNMFVEGFHDAILLYVLALHEVLR 334 (441) T ss_dssp ---------CCCHHHHHHHHHHHHHHHTT-T---------CCC----------CSSCCHHHHHHHHHHHHHHHHHHHHHH T ss_pred ---------CCChhHHHHHHHHHHHHHhc-C---------CCc----------cccchhHHHHHHHHHHHHHHHHHHHHH Confidence 00011111222222111100 0 000 012345678899999999999999865 Q NP_000836.2 422 DLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 422 ~~~~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ..+. ..++..+.+.|++..|.|.+| .+.|+++|++...+.+++++..+ ++.++.||.|+.. T Consensus 335 ~~~~----------~~~~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~i~~~~~~~-~g~~~~vg~~~~~ 395 (441) T 1JDP_A 335 AGYS----------KKDGGKIIQQTWNRTFEGIAG-QVSIDANGDRYGDFSVIAMTDVE-AGTQEVIGDYFGK 395 (441) T ss_dssp TTCC----------TTCHHHHHHHHSSEEEEETTE-EEEECTTSBBCCEEEEEEEEETT-TTEEEEEEEEETT T ss_pred cCCC----------CCCHHHHHHHhhcCeEeecce-eEEECCCCCccceEEEEEeecCC-CCeEEEEEEEECC Confidence 3211 123456777888889999998 89999999887778888876321 3578899999864 No 42 >4F11_A Gamma-aminobutyric acid type B receptor; Venus flytrap module, G-protein coupled; 2.38A {Homo sapiens} Probab=99.72 E-value=2e-22 Score=221.47 Aligned_cols=391 Identities=19% Similarity=0.262 Sum_probs=245.4 Template_Neff=11.600 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||+++|.++.... ...+.....|++.|++++|+.++ ++|+++++++.|+++++..+.+ T Consensus 8 ~~~~~~~i~ig~~~~~~~~~~~--------~~~~~~~~~~~~~a~~~~n~~~~-~~~~~i~l~~~d~~~~~~~~~~---- 74 (433) T 4F11_A 8 PPPSSPPLSIMGLMPLTKEVAK--------GSIGRGVLPAVELAIEQIRNESL-LRPYFLDLRLYDTECDNAKGLK---- 74 (433) T ss_dssp ---CCCEEEEEEEECCCTTSTT--------HHHHHHHHHHHHHHHHHHHHTTT-TTTCEEEEEEEECTTCHHHHHH---- T ss_pred CCCCCCCeEEEEEEecCCcccC--------CcccccHHHHHHHHHHHHHhccC-CCCceEEEEEEcCCCChhHHHH---- Confidence 3456789999999999864310 02456788999999999998764 5578899999998876544333 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+.+++.. .++++++||+.++..+..++.++...++|+|++.+..+.+.+...+++++++.++ T Consensus 75 ~~~~l~~~-----------------~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 137 (433) T 4F11_A 75 AFYDAIKY-----------------GPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPS 137 (433) T ss_dssp HHHHHHHH-----------------SCCCSEEEECCSHHHHHHHHHTHHHHTCEEEESSCCCGGGGCTTTCTTEEESSCC T ss_pred HHHHHHHh-----------------CCCeEEEEcCCChhHHHHHHHHccccCCeEEEeccCCHHHcCCCCCCceeeeCCC Confidence 33333320 0368899998888777778888889999999988766655443357889999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ...++.++++++++++|+++++++.++.++....+.+++.+++. ++++.....+. .++...+++++. .++++| T Consensus 138 ~~~~~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~-----~~~~~~~~~~~~-~~~~~v 210 (433) T 4F11_A 138 DNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGE-DIEISDTESFS-----NDPCTSVKKLKG-NDVRII 210 (433) T ss_dssp GGGHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHSSSS-SCEEEEEEEES-----SCCHHHHHHHHH-TTCCEE T ss_pred hhhhhHHHHHHHHHcCCCEEEEEEecchhhHHHHHHHHHHHhcC-CeEEEeeeeec-----CChhHHHHHHhc-CCcEEE Confidence 98889999999988899999999987777777778888877765 46654332221 235556667763 578888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVY-------------QQEEIAEGAVTILPKRASIDGFDRY 344 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~-------------~~~~~~~g~~~~~~~~~~~~~~~~~ 344 (908) ++.........+++++++.|+.. ++.|+..+ +........ .......+.+.+.........+..+ T Consensus 211 ~~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~ 289 (433) T 4F11_A 211 LGQFDQNMAAKVFCCAYEENMYGSKYQWIIPG-WYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTI 289 (433) T ss_dssp EEECCHHHHHHHHHHHHHTTCCSTTCEEEEES-CSCTTTTTCC------CCSCHHHHHHHHTTCEEEEECSSCCCCCCCT T ss_pred EEeCCHHHHHHHHHHHHHcCCcCCCeEEEccC-CcCcchhHHhhccccCCCccHHHHHHHHccceeeEeecCCCCCcccc Confidence 77766667788899988888753 45666654 221110000 0011122222221110000000000 Q NP_000836.2 345 FRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLC 424 (908) Q Consensus 345 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~ 424 (908) ......+ +.+.+.+... ...+..++..+|||++++++|++++....+ T Consensus 290 ----------~~~~~~~-~~~~~~~~~~----------------------~~~~~~~~~~~ydav~~~~~al~~~~~~~~ 336 (433) T 4F11_A 290 ----------SGKTPQQ-YEREYNNKRS----------------------GVGPSKFHGYAYDGIWVIAKTLQRAMETLH 336 (433) T ss_dssp ----------TSCCHHH-HHHHHHHHHT----------------------TSCCCTTHHHHHHHHHHHHHHHHHHHHHHH T ss_pred ----------CCCCHHH-HHHHHHHhcc----------------------CCChhhcchHHHHHHHHHHHHHHHHHHHHH Confidence 0000111 1111111000 012345678899999999999999875422 Q NP_000836.2 425 PGY---IGLCP-RMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQL---HL 497 (908) Q Consensus 425 ~~~---~~~~~-~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~---~~ 497 (908) ... ...|. .....++..+.++|++..|.|.+| .+.|+ +|++...+.+++++ ++.++.||.|+... .+ T Consensus 337 ~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~G~~G-~i~f~-~g~~~~~~~i~~~~----~g~~~~v~~~~~~~~~~~~ 410 (433) T 4F11_A 337 ASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTG-QVVFR-NGERMGTIKFTQFQ----DSREVKVGEYNAVADTLEI 410 (433) T ss_dssp HSSSCCCGGGCSSCCHHHHHHHHHHHHTCEEEETTE-EEEEE-TTEEECEEEEEEEE----TTEEEEEEEEETTTTEEEE T ss_pred hcCCCCchhhcCCCChHHHHHHHHHHHcCcEEeece-eEEee-CCceeeEEEEEEEE----CCcEEEEEEEECCCCeEEE Confidence 100 00000 001124556778888889999999 89999 89987788888887 35789999998642 12 Q NP_000836.2 498 KVEDMQWAH 506 (908) Q Consensus 498 ~~~~i~w~~ 506 (908) ....+.|.+ T Consensus 411 ~~~~~~w~g 419 (433) T 4F11_A 411 INDTIRFQG 419 (433) T ss_dssp CTTTCCCSS T ss_pred ecCcccCCC Confidence 223466754 No 43 >4MS4_B Gamma-aminobutyric acid type B receptor; heterodimeric protein complex, Venus Flytrap; HET: NAG, 2C0; 1.9A {Homo sapiens} Probab=99.72 E-value=2e-22 Score=221.47 Aligned_cols=391 Identities=19% Similarity=0.262 Sum_probs=246.4 Template_Neff=11.600 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||+++|.++.... ...+.....|++.|++++|+.++ ++|+++++++.|+++++..+.+ T Consensus 8 ~~~~~~~i~ig~~~~~~~~~~~--------~~~~~~~~~~~~~a~~~~n~~~~-~~~~~i~l~~~d~~~~~~~~~~---- 74 (433) T 4MS4_B 8 PPPSSPPLSIMGLMPLTKEVAK--------GSIGRGVLPAVELAIEQIRNESL-LRPYFLDLRLYDTECDNAKGLK---- 74 (433) T ss_dssp -CTTCCEEEEEEEECCCTTSTT--------HHHHHHHHHHHHHHHHHHHHTTT-TTTCEEEEEEEECTTCHHHHHH---- T ss_pred CCCCCCCeEEEEEEecCCcccC--------CcccccHHHHHHHHHHHHHhccC-CCCceEEEEEEcCCCChhHHHH---- Confidence 3456789999999999864310 02456788999999999998764 5578899999998876544333 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+.+++.. .++++++||+.++..+..++.++...++|+|++.+..+.+.+...+++++++.++ T Consensus 75 ~~~~l~~~-----------------~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 137 (433) T 4MS4_B 75 AFYDAIKY-----------------GPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPS 137 (433) T ss_dssp HHHHHHHH-----------------SCCCSEEEECCSHHHHHHHHHHGGGGTCEEEESSCCCGGGGCTTTCTTEEESSCC T ss_pred HHHHHHHh-----------------CCCeEEEEcCCChhHHHHHHHHccccCCeEEEeccCCHHHcCCCCCCceeeeCCC Confidence 33333320 0368899998888777778888889999999988766655443357889999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ...++.++++++++++|+++++++.++.++....+.+++.+++. ++++.....+. .++...+++++. .++++| T Consensus 138 ~~~~~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~-----~~~~~~~~~~~~-~~~~~v 210 (433) T 4MS4_B 138 DNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGE-DIEISDTESFS-----NDPCTSVKKLKG-NDVRII 210 (433) T ss_dssp GGGHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHTTT-TCEEEEEEEES-----SCTHHHHHHHHH-TTCCEE T ss_pred hhhhhHHHHHHHHHcCCCEEEEEEecchhhHHHHHHHHHHHhcC-CeEEEeeeeec-----CChhHHHHHHhc-CCcEEE Confidence 98889999999988899999999987777777778888877765 46654332221 235556667763 578888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVY-------------QQEEIAEGAVTILPKRASIDGFDRY 344 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~-------------~~~~~~~g~~~~~~~~~~~~~~~~~ 344 (908) ++.........+++++++.|+.. ++.|+..+ +........ .......+.+.+.........+..+ T Consensus 211 ~~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~ 289 (433) T 4MS4_B 211 LGQFDQNMAAKVFCCAYEENMYGSKYQWIIPG-WYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTI 289 (433) T ss_dssp EEECCHHHHHHHHHHHHHTTCCSTTCEEEEES-CSCTTTTC----------CCHHHHHHHHTTCEEEEECSSCCCCCCCT T ss_pred EEeCCHHHHHHHHHHHHHcCCcCCCeEEEccC-CcCcchhHHhhccccCCCccHHHHHHHHccceeeEeecCCCCCcccc Confidence 77766667788899988888753 45666654 221110000 0011122222221110000000000 Q NP_000836.2 345 FRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLC 424 (908) Q Consensus 345 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~ 424 (908) ......+ +.+.+.+... ...+..++..+|||++++++|++++....+ T Consensus 290 ----------~~~~~~~-~~~~~~~~~~----------------------~~~~~~~~~~~ydav~~~~~al~~~~~~~~ 336 (433) T 4MS4_B 290 ----------SGKTPQQ-YEREYNNKRS----------------------GVGPSKFHGYAYDGIWVIAKTLQRAMETLH 336 (433) T ss_dssp ----------TSSCHHH-HHHHHHHHCC----------------------SSCCCTTHHHHHHHHHHHHHHHHHHTCSSC T ss_pred ----------CCCCHHH-HHHHHHHhcc----------------------CCChhhcchHHHHHHHHHHHHHHHHHHHHH Confidence 0000111 1111111000 012345678899999999999999875422 Q NP_000836.2 425 PGY---IGLCP-RMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQL---HL 497 (908) Q Consensus 425 ~~~---~~~~~-~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~---~~ 497 (908) ... ...|. .....++..+.++|++..|.|.+| .+.|+ +|++...+.+++++ ++.++.||.|+... .+ T Consensus 337 ~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~G~~G-~i~f~-~g~~~~~~~i~~~~----~g~~~~v~~~~~~~~~~~~ 410 (433) T 4MS4_B 337 ASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTG-QVVFR-NGERMGTIKFTQFQ----DSREVKVGEYNAVADTLEI 410 (433) T ss_dssp HHHHHHHHHHCCSCCHHHHHHHHHHHHTCEEEETTE-EEEEE-TTEEECEEEEEEEC----SSCEEEEEEEETTTTEEEE T ss_pred hcCCCCchhhcCCCChHHHHHHHHHHHcCcEEeece-eEEee-CCceeeEEEEEEEE----CCcEEEEEEEECCCCeEEE Confidence 100 00000 001124556778888889999999 89999 89987788888887 35789999998642 12 Q NP_000836.2 498 KVEDMQWAH 506 (908) Q Consensus 498 ~~~~i~w~~ 506 (908) ....+.|.+ T Consensus 411 ~~~~~~w~g 419 (433) T 4MS4_B 411 INDTIRFQG 419 (433) T ss_dssp CTTTCCCSS T ss_pred ecCcccCCC Confidence 223466754 No 44 >4MQE_A Gamma-aminobutyric acid type B receptor; heterodimeric protein complex, Venus Flytrap; HET: MAN, NAG, FUC; 2.35A {Homo sapiens} Probab=99.67 E-value=2e-21 Score=212.36 Aligned_cols=376 Identities=21% Similarity=0.283 Sum_probs=233.6 Template_Neff=11.700 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.++.. ..+.....|++.|++++|+.+++++|+++++.+.|+++++..+ .+.+.+ T Consensus 3 ~~~i~Ig~i~p~~~~~-----------~~~~~~~~~~~~a~~~~n~~~~~~~g~~i~~~~~d~~~~~~~~----~~~~~~ 67 (420) T 4MQE_A 3 RRAVYIGALFPMSGGW-----------PGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQA----TKYLYE 67 (420) T ss_dssp CEEEEEEEEECSSSSC-----------CTHHHHHHHHHHHHHHHHHCTTTCSSEEEEEEEEECTTCHHHH----HHHHHH T ss_pred CceeEEEEEEecCCCC-----------CccccHHHHHHHHHHHHHcCCCCCCCcEEEEEEecCCCChHHH----HHHHHH Confidence 4689999999997642 2456788999999999999877666889999999887664432 333333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++++++||+.++.....++..+...++|+|++.+..+.+++...+++++++.++.... T Consensus 68 l~~------------------~~~v~~iig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 129 (420) T 4MQE_A 68 LLY------------------NDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLH 129 (420) T ss_dssp HHS------------------SSSCCSEEECCSHHHHHHHHHHGGGGTCEEEESSCCCGGGCCTTTCTTEEESSCCGGGH T ss_pred HHh------------------CCCeEEEEEcCchHHHHHHHHHHhhcCCEEEechhcChhhcCCCCCCceEecCCChhhc Confidence 332 14788999988777777777888899999999877665554333468899999998888 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) +.++++++++++|++|++++.++.++....+.+++.+++. ++++.....+. .+....+++++. .++|+|++.. T Consensus 130 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~-----~d~~~~~~~~~~-~~~~~ii~~~ 202 (420) T 4MQE_A 130 NPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEA-GIEITFRQSFF-----SDPAVPVKNLKR-QDARIIVGLF 202 (420) T ss_dssp HHHHHHHHHHHTCCEEEEEEESCHHHHHHHHHHHHHHHHT-TCEEEEEEEES-----SCCHHHHHHHHH-TTCCEEEEEC T ss_pred hHHHHHHHHHhCCcEEEEEEeCCcchhhHHHHHHHHHHHC-CcEEEEEeccc-----CCCchHHHHHHh-CCCEEEEEEC Confidence 8889998888899999999977777777778888887765 45554332221 234455666663 5788887776 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSG-HFLWIGSDS----WGSKIAPV-----YQQEEIAEGAVTILPKRASIDGFDRYFRSRTL-- 350 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~-~~~~i~~~~----~~~~~~~~-----~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~-- 350 (908) .......+++++++.|+.. .+.|+..+. |....... ........|.+...... +..... T Consensus 203 ~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~---------~~~~~~~~ 273 (420) T 4MQE_A 203 YETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVM---------LNPANTRS 273 (420) T ss_dssp CHHHHHHHHHHHHHTTCCSTTCEEEEESCSCTTGGGSCCTTCCSCHHHHHHHHTTCEEEEECC---------SCSSCCCC T ss_pred CHHHHHHHHHHHHHcCccCCCeEEEeecccccchhhhcCCCCCCCHHHHHHHHhcceeEEEec---------cCCCCCCc Confidence 6656778888888887643 345665431 11000000 00001122222111000 000000 Q NP_000836.2 351 ANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGY-IG 429 (908) Q Consensus 351 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~-~~ 429 (908) ...+....|.+.+.+.++.. +.......++..+|||++++++|++++........ .. T Consensus 274 ~~~~~~~~f~~~~~~~~~~~----------------------p~~~~~~~~~~~~ydav~~~~~al~~~~~~~~~~~~~~ 331 (420) T 4MQE_A 274 ISNMTSQEFVEKLTKRLKRH----------------------PEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRL 331 (420) T ss_dssp TTSCCHHHHHHHHHHHCSSC----------------------TTTSTTTTTHHHHHHHHHHHHHHHHHHC--------CG T ss_pred ccCCCHHHHHHHHHHHHhcC----------------------CccCCCCcchHHHHHHHHHHHHHHHHHhccCccCCCCH Confidence 00011111222222211100 00001124567899999999999998864321100 00 Q NP_000836.2 430 LCPR-MSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 430 ~~~~-~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .|.. .....+..+.+.+++..|.|.+| .+.||++|++...+.+.+++ ++.++.+|.|+.. T Consensus 332 ~~~~~~~~~~~~~l~~~l~~~~~~G~~G-~~~f~~~g~~~~~~~v~~~~----~~~~~~v~~~~~~ 392 (420) T 4MQE_A 332 EDFNYNNQTITDQIYRAMNSSSFEGVSG-HVVFDASGSRMAWTLIEQLQ----GGSYKKIGYYDST 392 (420) T ss_dssp GGCCTTCHHHHHHHHHHHHTCCEEETTE-EECBCTTSBBCCEEEEEEEC----SSSEEEEEEEETT T ss_pred HHcCCCChHHHHHHHHHHhcCceecccc-eEEEcCCCCcceeEEEEEee----CCceEEEEEEEcC Confidence 0000 00123445667777788999988 89999999987777788876 3578899999865 No 45 >4MS4_A Gamma-aminobutyric acid type B receptor; heterodimeric protein complex, Venus Flytrap; HET: 2C0, NAG; 1.9A {Homo sapiens} Probab=99.67 E-value=2e-21 Score=212.36 Aligned_cols=376 Identities=21% Similarity=0.283 Sum_probs=233.6 Template_Neff=11.700 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.++.. ..+.....|++.|++++|+.+++++|+++++.+.|+++++..+ .+.+.+ T Consensus 3 ~~~i~Ig~i~p~~~~~-----------~~~~~~~~~~~~a~~~~n~~~~~~~g~~i~~~~~d~~~~~~~~----~~~~~~ 67 (420) T 4MS4_A 3 RRAVYIGALFPMSGGW-----------PGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQA----TKYLYE 67 (420) T ss_dssp CEEEEEEEEECSSSSC-----------CTHHHHHHHHHHHHHHHHTCTTTCTTEEEEEEEEECTTCHHHH----HHHHHH T ss_pred CceeEEEEEEecCCCC-----------CccccHHHHHHHHHHHHHcCCCCCCCcEEEEEEecCCCChHHH----HHHHHH Confidence 4689999999997642 2456788999999999999877666889999999887664432 333333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++++++||+.++.....++..+...++|+|++.+..+.+++...+++++++.++.... T Consensus 68 l~~------------------~~~v~~iig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 129 (420) T 4MS4_A 68 LLY------------------NDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLH 129 (420) T ss_dssp HHS------------------SSSCCSEEECCSHHHHHHHHHHGGGGTCEEEESSCCCGGGGCTTTSTTEEESSCCGGGH T ss_pred HHh------------------CCCeEEEEEcCchHHHHHHHHHHhhcCCEEEechhcChhhcCCCCCCceEecCCChhhc Confidence 332 14788999988777777777888899999999877665554333468899999998888 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) +.++++++++++|++|++++.++.++....+.+++.+++. ++++.....+. .+....+++++. .++|+|++.. T Consensus 130 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~-----~d~~~~~~~~~~-~~~~~ii~~~ 202 (420) T 4MS4_A 130 NPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEA-GIEITFRQSFF-----SDPAVPVKNLKR-QDARIIVGLF 202 (420) T ss_dssp HHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEES-----SCCHHHHHHHHH-TTCCEEEEEC T ss_pred hHHHHHHHHHhCCcEEEEEEeCCcchhhHHHHHHHHHHHC-CcEEEEEeccc-----CCCchHHHHHHh-CCCEEEEEEC Confidence 8889998888899999999977777777778888887765 45554332221 234455666663 5788887776 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSG-HFLWIGSDS----WGSKIAPV-----YQQEEIAEGAVTILPKRASIDGFDRYFRSRTL-- 350 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~-~~~~i~~~~----~~~~~~~~-----~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~-- 350 (908) .......+++++++.|+.. .+.|+..+. |....... ........|.+...... +..... T Consensus 203 ~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~---------~~~~~~~~ 273 (420) T 4MS4_A 203 YETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVM---------LNPANTRS 273 (420) T ss_dssp CHHHHHHHHHHHHHHTCCSTTCEEEEETTSCTTGGGSCCTTCCCCHHHHHHHHTTCEEEEECC---------SCSSCCCC T ss_pred CHHHHHHHHHHHHHcCccCCCeEEEeecccccchhhhcCCCCCCCHHHHHHHHhcceeEEEec---------cCCCCCCc Confidence 6656778888888887643 345665431 11000000 00001122222111000 000000 Q NP_000836.2 351 ANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGY-IG 429 (908) Q Consensus 351 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~-~~ 429 (908) ...+....|.+.+.+.++.. +.......++..+|||++++++|++++........ .. T Consensus 274 ~~~~~~~~f~~~~~~~~~~~----------------------p~~~~~~~~~~~~ydav~~~~~al~~~~~~~~~~~~~~ 331 (420) T 4MS4_A 274 ISNMTSQEFVEKLTKRLKRH----------------------PEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRL 331 (420) T ss_dssp TTSCCHHHHHHHHHHHCSSC----------------------GGGSTTTTTHHHHHHHHHHHHHHHHHHC--------CG T ss_pred ccCCCHHHHHHHHHHHHhcC----------------------CccCCCCcchHHHHHHHHHHHHHHHHHhccCccCCCCH Confidence 00011111222222211100 00001124567899999999999998864321100 00 Q NP_000836.2 430 LCPR-MSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 430 ~~~~-~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .|.. .....+..+.+.+++..|.|.+| .+.||++|++...+.+.+++ ++.++.+|.|+.. T Consensus 332 ~~~~~~~~~~~~~l~~~l~~~~~~G~~G-~~~f~~~g~~~~~~~v~~~~----~~~~~~v~~~~~~ 392 (420) T 4MS4_A 332 EDFNYNNQTITDQIYRAMNSSSFEGVSG-HVVFDASGSRMAWTLIEQLQ----GGSYKKIGYYDST 392 (420) T ss_dssp GGCCTTCSHHHHHHHHHHHTCEEEETTE-EEECCTTTCSCCEEEEEEEE----TTEEEEEEEEETT T ss_pred HHcCCCChHHHHHHHHHHhcCceecccc-eEEEcCCCCcceeEEEEEee----CCceEEEEEEEcC Confidence 0000 00123445667777788999988 89999999987777788876 3578899999865 No 46 >3Q41_C Glutamate [NMDA] receptor subunit zeta-1; NTD, NMDA, GluN1, ion channel; HET: NAG; 3.4A {Rattus norvegicus} Probab=99.66 E-value=4.8e-21 Score=206.51 Aligned_cols=348 Identities=19% Similarity=0.271 Sum_probs=226.6 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI--LDTCSRDTYALEQSLTF 119 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~--~d~~~~~~~a~~~~~~~ 119 (908) ..++++||+++|.+ ....|++.|++++|++++ +.++++.. .|++.++.. .+.+. T Consensus 3 ~~~~i~Ig~i~~~~------------------~~~~~~~~a~~~~n~~~~---~~~i~l~~~~~d~~~~~~~---~~~~~ 58 (384) T 3Q41_C 3 DPKIVNIGAVLSTR------------------KHEQMFREAVNQANKRHG---SWKIQLNATSVTHKPNAIQ---MALSV 58 (384) T ss_dssp -CCCBEEEEEESSH------------------HHHHHHHHHHHTTTTTSC---TTTSCBCCEEEECCSSSSH---HHHHC T ss_pred CCceeEEEeeechH------------------HHHHHHHHHHHHHHhcCC---CcceEEEEEEecCCCCHHH---HHHHH Confidence 35789999999874 245789999999998754 34566655 776654322 12222 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAAS-----SVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSR 194 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s-----~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~ 194 (908) .+.+.. +++++++|+..+ .....++.++...++|+|++.+..+.+.+...++++++ T Consensus 59 ~~~l~~-------------------~~v~~vig~~~~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~ 119 (384) T 3Q41_C 59 CEDLIS-------------------SQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLR 119 (384) T ss_dssp CCCCGG-------------------GCEEEEEECCCCSTTTTTTHHHHHHHHHTTTCCEEESSCCCGGGTCTTSCTTEEE T ss_pred HHHHHh-------------------cCceEEEEcCCCCCCCCCChhHHHHHhHhcCCCEEecccCChhHcCCcccccEee Confidence 222221 478899997665 24456677888899999998876665554434688999 Q NP_000836.2 195 VVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 195 ~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) +.++....+.++++++++++|+++++++.++.++....+.+++.+++. ++++.....+. ....+....+++++. .+ T Consensus 120 ~~~~~~~~~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~l~~-~~ 195 (384) T 3Q41_C 120 TVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEER-ESKAEKVLQFD--PGTKNVTALLMEARE-LE 195 (384) T ss_dssp SSCCSGGGHHHHHHHHHTTTCCCCEEEEESSHHHHHHHHHHHHHHHTS-SCCCSEEEEEC--SSCSCCHHHHHHHHT-SS T ss_pred cCCCHHHHHHHHHHHHHHcCCcEEEEEEecCcChhHHHHHHHHHHHhc-CceeEEEEeeC--CCChhHHHHHHHHHh-CC Confidence 999998889999999988899999999987777777777888777765 35554332222 122345566777763 57 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANN 353 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~ 353 (908) +++|++.........+++++++.|+.. ++.|+..+.|..... ......+.+. T Consensus 196 ~~~ii~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~----~~~~~~~~~~----------------------- 248 (384) T 3Q41_C 196 ARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNA----LRYAPDGIIG----------------------- 248 (384) T ss_dssp CCEEEEECCHHHHHHHHHHHHTTTCSSTTCEEEECSSTTSTHH----HHHCCTTCEE----------------------- T ss_pred CeEEEEECCHHHHHHHHHHHHHcCCcCCCeEEEEecccCCcch----HhhCCCcEEE----------------------- Confidence 888888777777788888888888753 456766543321100 0000000000 Q NP_000836.2 354 RRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG-YIGLCP 432 (908) Q Consensus 354 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~-~~~~~~ 432 (908) + . . ..+..++..+|||++++++|++++....+.. ....|. T Consensus 249 -----~----~-~-----------------------------~~~~~~~~~~yDa~~~~~~al~~~~~~~~~~~~~~~c~ 289 (384) T 3Q41_C 249 -----L----Q-L-----------------------------INGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCV 289 (384) T ss_dssp -----E----E-E-----------------------------TTTTCHHHHHHHHHHHHHHHHHHHTTSSSCCCCCSCCT T ss_pred -----E----E-e-----------------------------cCCCcchhHHHHHHHHHHHHHHHHHHccCCCCCCCCcc Confidence 0 0 0 0112456789999999999999887543211 011222 Q NP_000836.2 433 RM--STIDGKELLGYIRA-VNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLH-LKVEDMQWAHR 507 (908) Q Consensus 433 ~~--~~~~~~~l~~~l~~-~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~-~~~~~i~w~~~ 507 (908) .. ....+..+.+.|++ ..|.|.+| .+.||++|++. ..+.+++++ ++.++.||.|+.... +....+.|.++ T Consensus 290 ~~~~~~~~~~~l~~~l~~~~~~~g~~G-~i~fd~~g~~~~~~~~i~~~~----~~~~~~vg~~~~~~~~~~~~~~~w~~~ 364 (384) T 3Q41_C 290 GNTNIWKTGPLFKRVLMSSKYADGVTG-RVEFNEDGDRKFANYSIMNLQ----NRKLVQVGIYNGTHVIPNDRKIIWPGG 364 (384) T ss_dssp TCCCCCTHHHHHHHHHHSCEECSCSSS-CEECCSSSCCCCCCEEEEEEE----TTEEEEEEEEETTEEEECSSCCCBTTT T ss_pred CCCchhccHHHHHHHHhcCCcccCCCc-cEEECCCCCccceEEEEEEee----CCcEEEEEEEeCCCcccCCCCccCCCC Confidence 11 11234456677765 46899988 89999999985 788888887 357899999986531 22235778653 No 47 >5KC8_A Glutamate receptor ionotropic, delta-2; ionotropic glutamate receptor (iGluR), neurotransmission; HET: EDO; 1.751A {Homo sapiens} Probab=99.64 E-value=9.9e-21 Score=207.43 Aligned_cols=378 Identities=16% Similarity=0.219 Sum_probs=229.7 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILD-TCSRDTYALEQSLTFV 120 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d-~~~~~~~a~~~~~~~~ 120 (908) .+++++||+++|.++. ....|+++|++++|+++++++|.++++.+.| +++++..+.+. + T Consensus 3 ~~~~i~Ig~i~p~sg~----------------~~~~a~~~A~~~in~~~~~~~~~~i~~~~~d~~~~~~~~~~~~----~ 62 (429) T 5KC8_A 3 GDSIIHIGAIFDESAK----------------KDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQE----A 62 (429) T ss_dssp -CCCEEEEEEEETTCH----------------HHHHHHHHHHHHHHHCTTSSTTCCEEEEEEEECTTCHHHHHHH----H T ss_pred CCceeeeEEEeeCCCh----------------hHHHHHHHHHHHHHhCCCccCCCeEEEEEEecCCCCHHHHHHH----H Confidence 4578999999998752 4668999999999998777778899999888 66654433332 3 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELS--------DNTRYDFF 192 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~--------~~~~~~~~ 192 (908) .+++. ++++++||+.++..+..++.++...+||+|++.+.++.+. ....++++ T Consensus 63 ~~l~~-------------------~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~ 123 (429) T 5KC8_A 63 CELMN-------------------QGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYT 123 (429) T ss_dssp HHHHH-------------------HCCSCEEEEECHHHHHHHHHHHHHHTCCEEEEECCSTTCCCCCCCCCCCCSSCCCE T ss_pred HHHHh-------------------cCceEEEcCCChHHHHHHHHHHHhcCCCEEEeecCCCCCCCCcCCccccCCCCcce Confidence 33322 4788999998887777788888999999999877654211 11246889 Q NP_000836.2 193 SRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIP------REPRPGEFEKII 266 (908) Q Consensus 193 ~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~------~~~~~~~~~~~~ 266 (908) +++.|+. .+++++++++++++|++|++++.+ +++....+.+.+.+++. ++++......+ ......++...+ T Consensus 124 ~~~~p~~-~~~~a~~~~l~~~~~~~v~ii~~~-~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~~~l 200 (429) T 5KC8_A 124 LSVRPPV-YLHDVILRVVTEYAWQKFIIFYDS-EYDIRGIQEFLDKVSQQ-GMDVALQKVENNINKMITTLFDTMRIEEL 200 (429) T ss_dssp EECSCCC-CHHHHHHHHHHHTTCCEEEEEECT-TCCGGGGHHHHHHHHHT-TCEEEEEECCSCHHHHHHHHHHHCCHHHH T ss_pred eecCCCh-hHHHHHHHHHHHcCCCEEEEEeCC-hHHHHHHHHHHHHHHhc-CceEEEEeecccccccchhhhhhhHHHHH Confidence 9999987 788899999988999999999975 67777777788777665 35554321110 001123455666 Q NP_000836.2 267 KRLLETPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 267 ~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) ++++. .+ +.|++......+..+++++++.|+.. .+.|+..+.+...............+...+.... T Consensus 201 ~~~~~-~~-~~vv~~~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~---------- 268 (429) T 5KC8_A 201 NRYRD-TL-RRAILVMNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTF---------- 268 (429) T ss_dssp HHHHH-HT-TEEEEESCHHHHHHHHHHHHHTTSSCTTCEEEEECSCCCHHHHHHHHHHCCSEEEEEEEEC---------- T ss_pred HHHhh-cC-CEEEEEcCHHHHHHHHHHHHHcCCCcCCeEEEEecCCccccchHHHHHHHhcceEEEEeec---------- Confidence 66653 34 44445555667788999999888764 4567766533221110000000111111111000 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) .. .......+|.+.+++.+.. |...... ...+..++..+|||++++++|++++....+. T Consensus 269 ~~---~~~~~~~~f~~~~~~~~~~--------------~~~~~~~----~~~~~~~~~~~yDav~~~~~al~~~~~~~~~ 327 (429) T 5KC8_A 269 PV---PQNISQRCFRGNHRISSTL--------------CDPKDPF----AQNMEISNLYIYDTVLLLANAFHKKLEDRKW 327 (429) T ss_dssp CC---CCSHHHHSEETTEECCHHH--------------HCTTSHH----HHTCCHHHHHHHHHHHHHHHHHHHHHHTTCC T ss_pred CC---ChhhchhhHhhcccccccC--------------CCCCCcc----ccccChHHHHHHHHHHHHHHHHHHHHHcccc Confidence 00 0000111122222222110 0000000 0123456788999999999999988754321 Q NP_000836.2 426 G--YIGLCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITN-KSTEYKVIGHWTNQL 495 (908) Q Consensus 426 ~--~~~~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~-~~~~~~~Vg~~~~~~ 495 (908) . ....|... ...++..+.+.|++..|.|.+| ++.|+++|++. ..+.|++++... .++.++.||.|+... T Consensus 328 ~~~~~~~c~~~~~~~~~~~~~l~~~l~~~~f~G~~G-~i~f~~~g~~~~~~~~i~~~~~~~~~~~~~~~vg~w~~~~ 403 (429) T 5KC8_A 328 HSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTG-ELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVT 403 (429) T ss_dssp CCCCCCCSSSTTCCCCTTHHHHHHHHHTCEEEETTE-EEECCTTSBCCCCEEEEEEC--------CCEEEEEEETTT T ss_pred cCCCCCccccccCCccccHHHHHHHHHhCceeecce-eEEeCCCCCcCcceEEEEeeecccccCCCeEEEEEEeCCC Confidence 0 01122211 0114556778888889999999 89999999886 577888887310 124689999998753 No 48 >3OM0_A Glutamate receptor, ionotropic kainate 5; Membrane Protein, Ion channel; HET: BMA, GOL, NAG; 1.401A {Rattus norvegicus} Probab=99.62 E-value=2.1e-20 Score=201.91 Aligned_cols=370 Identities=15% Similarity=0.164 Sum_probs=229.1 Template_Neff=12.200 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||+++|.++. .+.....|+++|++++|+++++++|+++++++.|++++... .+.+.+++ T Consensus 2 ~~~i~ig~~~~~~~~-------------~g~~~~~~~~~a~~~~n~~~~~~~~~~l~~~~~d~~~~~~~---~~~~~~~~ 65 (393) T 3OM0_A 2 LSSLRMAAILDDQTV-------------CGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQY---ETTDTMCQ 65 (393) T ss_dssp CCEEEEEEEECCCCS-------------SCCCHHHHHHHHHHHHHHSCCSSCCCEEEEEEEECCSSCHH---HHHHHHHH T ss_pred CccceeeeeecCCCC-------------CcHHHHHHHHHHHHHHHccCCCCCCCEEEEEEEEcCCCChH---HHHHHHHH Confidence 468999999998763 45678899999999999988777788999999887654321 12222333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASS-VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~-~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +.. ++++++||+.++. ....++.++...++|+|++.+.++.+... .+++++++.|++.. T Consensus 66 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~~~ 125 (393) T 3OM0_A 66 ILP-------------------KGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQY-LRFASVSLYPSNED 125 (393) T ss_dssp HGG-------------------GCCSCEECCSSCHHHHHHHHHHHHHHTCCEEECSCCCCC-----CCSCCEESSCCHHH T ss_pred hcc-------------------cCceEEECCCCCHHhHHHHHHHHhhcCCCEEEecCCCCccccc-ceeeEEEcCCCHHH Confidence 322 5789999998875 56777888899999999988765544322 35678899999888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .+.++++++++++|+++++++.+++++....+ +.+.+++. +..+ ....+. ...++...+++++. .++++|++. T Consensus 126 ~~~~l~~~l~~~~~~~v~ii~~~~~~~~~~~~-~~~~~~~~-~~~~-~~~~~~---~~~~~~~~~~~l~~-~~~~~i~~~ 198 (393) T 3OM0_A 126 VSLAVSRILKSFNYPSASLICAKAECLLRLEE-LVRGFLIS-KETL-SVRMLD---DSRDPTPLLKEIRD-DKVSTIIID 198 (393) T ss_dssp HHHHHHHHHHHTTSCCEEEEESSTTHHHHTHH-HHHHHHHS-SSCE-EEEECC----CCCSHHHHHHHHH-HTCSEEEEE T ss_pred HHHHHHHHHHHcCCCeEEEEEechhHHHHHHH-HHHhhccC-CCee-EEEecC---CCCCcHHHHHHHhc-CCCcEEEEE Confidence 89999999988899999999977766654444 44444432 2111 111111 22345566777763 578999888 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ........+++++++.|+.. .+.|+..+........ ........+...+... . ...+....|. T Consensus 199 ~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~----~~~~~~~~f~ 262 (393) T 3OM0_A 199 ANASISHLVLRKASELGMTSAFYKYILTTMDFPILHL-DGIVEDSSNILGFSMF-----------N----TSHPFYPEFV 262 (393) T ss_dssp SCHHHHHHHHHHHHHTTTTSTTCEEEECCTTGGGCCC-TTTCCSSCSEEEEECC-----------C----TTSTTHHHHH T ss_pred CCHHHHHHHHHHHHHcCCCCCCceEEEcCCCcccCCH-HHhcccCceEEEEEEe-----------c----CCCccHHHHH Confidence 77777888999998888753 3456654321111000 0001111111111100 0 0011111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG-YIGLCPRMS-TID 438 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~-~~~~~~~~~-~~~ 438 (908) +.+.+.+.. .|... ....+..++..+|||+++++++++++....+.. ....|.... ..+ T Consensus 263 ~~~~~~~~~-------------~~~~~------~~~~~~~~~~~~yda~~~~~~a~~~~~~~~~~~~~~~~c~~~~~~~~ 323 (393) T 3OM0_A 263 RSLNMSWRE-------------NCEAS------TYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPH 323 (393) T ss_dssp HHHHHHHTT-------------TSCGG------GCCSCCHHHHHHHHHHHHHHHHHHHHTTTSCCCCCCCCTTCCCCCTT T ss_pred HHHHHhchh-------------ccccC------CCCCCChhHHHHHHHHHHHHHHHHHHHHcCCCCCCCCCCCCcccchh Confidence 222222211 01000 001234567789999999999999986532110 112232111 124 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) +..+.+.|++..|.|.+| ++.||++|++.. .+.+++++ .+.+..||.|.... T Consensus 324 ~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~ 376 (393) T 3OM0_A 324 GTSLMNYLRMVEYDGLTG-RVEFNSKGQRTNYTLRILEKS----RQGHREIGVWYSNR 376 (393) T ss_dssp HHHHHHHHTTCCEEETTE-EECBCTTSCBCSCEEEEEEEE----TTEEEEEEEEECC- T ss_pred HHHHHHHHhcCccccccc-eeeeCCCCCcCceEEEEEEec----ccceEEEEEEecCC Confidence 556778888889999988 899999998875 77787776 25688999998764 No 49 >3QLU_B Glutamate receptor, ionotropic kainate 5; Membrane protein, Glycosylation; HET: NAG, GOL; 2.906A {Rattus norvegicus} Probab=99.62 E-value=2.1e-20 Score=201.91 Aligned_cols=370 Identities=15% Similarity=0.164 Sum_probs=231.0 Template_Neff=12.200 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||+++|.++. .+.....|+++|++++|+++++++|+++++++.|++++... .+.+.+++ T Consensus 2 ~~~i~ig~~~~~~~~-------------~g~~~~~~~~~a~~~~n~~~~~~~~~~l~~~~~d~~~~~~~---~~~~~~~~ 65 (393) T 3QLU_B 2 LSSLRMAAILDDQTV-------------CGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQY---ETTDTMCQ 65 (393) T ss_dssp CCCEEEEEEECCCSS-------------SCCSHHHHHHHHHHHHHHSCCSSCCCCEEEEEEECSSSCHH---HHHHHHHH T ss_pred CccceeeeeecCCCC-------------CcHHHHHHHHHHHHHHHccCCCCCCCEEEEEEEEcCCCChH---HHHHHHHH Confidence 468999999998763 45678899999999999988777788999999887654321 12222333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASS-VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~-~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +.. ++++++||+.++. ....++.++...++|+|++.+.++.+... .+++++++.|++.. T Consensus 66 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~~~ 125 (393) T 3QLU_B 66 ILP-------------------KGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQY-LRFASVSLYPSNED 125 (393) T ss_dssp HGG-------------------GCCSCEECCSSCHHHHHHHHHHHHHHTCCEEECSCCSCCCCTT-SCCCEEESSCCHHH T ss_pred hcc-------------------cCceEEECCCCCHHhHHHHHHHHhhcCCCEEEecCCCCccccc-ceeeEEEcCCCHHH Confidence 322 5789999998875 56777888899999999988765544322 35678899999888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .+.++++++++++|+++++++.+++++....+ +.+.+++. +..+ ....+. ...++...+++++. .++++|++. T Consensus 126 ~~~~l~~~l~~~~~~~v~ii~~~~~~~~~~~~-~~~~~~~~-~~~~-~~~~~~---~~~~~~~~~~~l~~-~~~~~i~~~ 198 (393) T 3QLU_B 126 VSLAVSRILKSFNYPSASLICAKAECLLRLEE-LVRGFLIS-KETL-SVRMLD---DSRDPTPLLKEIRD-DKVSTIIID 198 (393) T ss_dssp HHHHHHHHHHHTTSCCEEEEESSTTHHHHTHH-HHTTSCBB-TTTE-EEEECC---SSCCCHHHHHHHHH-TTCCEEEEE T ss_pred HHHHHHHHHHHcCCCeEEEEEechhHHHHHHH-HHHhhccC-CCee-EEEecC---CCCCcHHHHHHHhc-CCCcEEEEE Confidence 89999999988899999999977766654444 44444432 2111 111111 22345566777763 578999888 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ........+++++++.|+.. .+.|+..+........ ........+...+... . ...+....|. T Consensus 199 ~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~----~~~~~~~~f~ 262 (393) T 3QLU_B 199 ANASISHLVLRKASELGMTSAFYKYILTTMDFPILHL-DGIVEDSSNILGFSMF-----------N----TSHPFYPEFV 262 (393) T ss_dssp SCHHHHHHHHHHHHHTTTTSSSCEEEECCSCCTTCCC-TTTCCSSCEEEEEECC-----------C----TTSTTHHHHH T ss_pred CCHHHHHHHHHHHHHcCCCCCCceEEEcCCCcccCCH-HHhcccCceEEEEEEe-----------c----CCCccHHHHH Confidence 77777888999998888753 3456654321111000 0001111111111100 0 0011111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG-YIGLCPRMS-TID 438 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~-~~~~~~~~~-~~~ 438 (908) +.+.+.+.. .|... ....+..++..+|||+++++++++++....+.. ....|.... ..+ T Consensus 263 ~~~~~~~~~-------------~~~~~------~~~~~~~~~~~~yda~~~~~~a~~~~~~~~~~~~~~~~c~~~~~~~~ 323 (393) T 3QLU_B 263 RSLNMSWRE-------------NCEAS------TYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPH 323 (393) T ss_dssp HHHHHHHHH-------------HCSSS------CCCCCCHHHHHHHHHHHHHHHHHHHHHTTSCCCCCCCCTTSCCCCTT T ss_pred HHHHHhchh-------------ccccC------CCCCCChhHHHHHHHHHHHHHHHHHHHHcCCCCCCCCCCCCcccchh Confidence 222222211 01000 001234567789999999999999986532110 112232111 124 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) +..+.+.|++..|.|.+| ++.||++|++.. .+.+++++ .+.+..||.|.... T Consensus 324 ~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~ 376 (393) T 3QLU_B 324 GTSLMNYLRMVEYDGLTG-RVEFNSKGQRTNYTLRILEKS----RQGHREIGVWYSNR 376 (393) T ss_dssp HHHHHHHHHTCCEEETTE-EECBCTTSCBCSCEEEEEECC----SSSCCEEEEEESSS T ss_pred HHHHHHHHhcCccccccc-eeeeCCCCCcCceEEEEEEec----ccceEEEEEEecCC Confidence 556778888889999988 899999998875 77787776 25688999998764 No 50 >5FWY_B GLUTAMATE RECEPTOR 2, GLUTAMATE RECEPTOR; TRANSPORT PROTEIN; HET: SO4, NAG; 2.12A {RATTUS NORVEGICUS} Probab=99.62 E-value=2.4e-20 Score=201.38 Aligned_cols=372 Identities=13% Similarity=0.153 Sum_probs=227.7 Template_Neff=11.900 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDL-LSNITLGVRILD-TCSRDTYALEQSLTFV 120 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~i-l~g~~l~~~~~d-~~~~~~~a~~~~~~~~ 120 (908) +++++||+++|.++. ....|++.|++++|+++++ ++|+++++++.| +.+++.. ..+.+ T Consensus 3 ~~~i~Ig~~~~~~~~----------------~~~~~~~~a~~~~n~~g~~~~~g~~l~~~~~d~~~~~~~~----~~~~~ 62 (390) T 5FWY_B 3 PNTISIGGLFMRNTV----------------QEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFS----VTNAF 62 (390) T ss_dssp CSEEEEEEEECTTCH----------------HHHHHHHHHHHHHHTCCCTTTCSSEEEEEEEECSSCCHHH----HHHHH T ss_pred CceeEEEEeecCCCH----------------HHHHHHHHHHHHHHcCCCCCCCCceEEEEEEecCCCChHH----HHHHH Confidence 568999999998752 4668999999999998765 357888888876 4444332 22233 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) .+++. +++++++|+.++..+..++..+...++|+|++..... ..+++++++.|+ T Consensus 63 ~~l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~p~-- 116 (390) T 5FWY_B 63 CSQFS-------------------RGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTD-----ADVQFVIQMRPA-- 116 (390) T ss_dssp HHHHH-------------------HCCSCEEECCCTTTHHHHHHHHHHHTCCEEECSCCCS-----SCCSSEEECSCC-- T ss_pred HHHhh-------------------CCeeEEEcCCCchhHHHHHHHHHhcCCceeeCCCCCC-----CCCCcEEEeecc-- Confidence 33322 5788999998887777788888999999998775432 246788998887 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) +++++++++++++|+++++++++ .++....+.+++.+++. ++++......+. .+..++...+++++. .++++|++ T Consensus 117 -~~~~~~~~~~~~~~~~v~vl~~~-~~~~~~~~~~~~~~~~~-~~~v~~~~~~~~-~~~~~~~~~~~~l~~-~~~~~vv~ 191 (390) T 5FWY_B 117 -LKGAILSLLSYYKWEKFVYLYDT-ERGFSVLQAIMEAAVQN-NWQVTARSVGNI-KDVQEFRRIIEEMDR-RQEKRYLI 191 (390) T ss_dssp -CHHHHHHHHHHTTCCEEEEEECS-TTCSHHHHHHHHHHHHH-TCEEEEEECTTC-CSHHHHHHHHHHHHH-TTCCEEEE T ss_pred -HHHHHHHHHHHcCCcEEEEEEeC-cccHHHHHHHHHHHHhC-CCeEEEEEeCCC-CCHHHHHHHHHHHhh-cCCcEEEE Confidence 46788888888899999999954 67777777777777664 345433211110 122456667777763 57898888 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) ......+..+++++++.|+.. .+.|+..+.+...... ........+...+.... ...+....| T Consensus 192 ~~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~~---------------~~~~~~~~f 255 (390) T 5FWY_B 192 DCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILL-ERVMHGGANITGFQIVN---------------NENPMVQQF 255 (390) T ss_dssp ESCHHHHHHHHHHHHHTTCCSTTCEEEECCTTGGGSCC-HHHHHHTCEEEEEESCC---------------TTSHHHHHH T ss_pred ECCHHHHHHHHHHHHHhCCccCCeeEEEecCCcchhcH-HHHhcCCccEEEEEEec---------------CCCHHHHHH Confidence 776677788899998888753 3556665433221100 00001111111111000 001111223 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~~~~- 434 (908) .+.+++.+...... .+ ...+..++..+||+++++++|++++...... .....|... T Consensus 256 ~~~~~~~~~~~~~~---------~~----------~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~c~~~~ 316 (390) T 5FWY_B 256 IQRWVRLDEREFPE---------AK----------NAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANP 316 (390) T ss_dssp HHHHTTSCTTTSTT---------CT----------TSCCCHHHHHHHHHHHHHHHHHHHHHHTTCCCCSSSCCSCTTCSS T ss_pred HHHHHhcCcccCCC---------CC----------CCCCChHHHHHHHHHHHHHHHHHHHHHcCCCcccCCCCCcccCCC Confidence 23232222110000 00 0123456778999999999999988653210 001122110 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ...++..+.+.|++..|.|.+| ++.||++|++. ..+.+++++. +.++.+|.|.....++.....|+ T Consensus 317 ~~~~~~~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~~i~~~~~----~~~~~vg~w~~~~~~~~~~~~~~ 385 (390) T 5FWY_B 317 AVPWSQGIDIERALKMVQVQGMTG-NIQFDTYGRRTNYTIDVYEMKV----SGSRKAGYWNEYERFVPFSGTKH 385 (390) T ss_dssp CCCCTTHHHHHHHHHTCCEEETTE-EEEECTTSCEESCCEEEEEEC------CEEEEEEEETTTEEEECCC--- T ss_pred CCcchhHHHHHHHHhcCCccCCCc-eEEECCCCceeeeEEEEEEeee----cCcEEEEEEcCCCccccCCCCCC Confidence 0114556778888889999998 89999988886 4778888762 46889999987654444445564 No 51 >6FPJ_A Glutamate receptor 3; ligand-gated ion channel, membrane protein; HET: DMS, NAG, PO4; 1.96A {Rattus norvegicus} Probab=99.62 E-value=2.4e-20 Score=201.38 Aligned_cols=372 Identities=13% Similarity=0.153 Sum_probs=227.2 Template_Neff=11.900 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDL-LSNITLGVRILD-TCSRDTYALEQSLTFV 120 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~i-l~g~~l~~~~~d-~~~~~~~a~~~~~~~~ 120 (908) +++++||+++|.++. ....|++.|++++|+++++ ++|+++++++.| +.+++.. ..+.+ T Consensus 3 ~~~i~Ig~~~~~~~~----------------~~~~~~~~a~~~~n~~g~~~~~g~~l~~~~~d~~~~~~~~----~~~~~ 62 (390) T 6FPJ_A 3 PNTISIGGLFMRNTV----------------QEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFS----VTNAF 62 (390) T ss_dssp CSEEEEEEEEETTCH----------------HHHHHHHHHHHHHHTCCCTTTCSSEEEEEEEEESCSSHHH----HHHHH T ss_pred CceeEEEEeecCCCH----------------HHHHHHHHHHHHHHcCCCCCCCCceEEEEEEecCCCChHH----HHHHH Confidence 568999999998752 4668999999999998765 357888888876 4444332 22233 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) .+++. +++++++|+.++..+..++..+...++|+|++..... ..+++++++.|+ T Consensus 63 ~~l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~p~-- 116 (390) T 6FPJ_A 63 CSQFS-------------------RGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTD-----ADVQFVIQMRPA-- 116 (390) T ss_dssp HHHHH-------------------HCCSCEEECCCTTTHHHHHHHHHHTTCCEEECSCCCS-----SCCSSEEECSCC-- T ss_pred HHHhh-------------------CCeeEEEcCCCchhHHHHHHHHHhcCCceeeCCCCCC-----CCCCcEEEeecc-- Confidence 33322 5788999998887777788888999999998775432 246788998887 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) +++++++++++++|+++++++++ .++....+.+++.+++. ++++......+. .+..++...+++++. .++++|++ T Consensus 117 -~~~~~~~~~~~~~~~~v~vl~~~-~~~~~~~~~~~~~~~~~-~~~v~~~~~~~~-~~~~~~~~~~~~l~~-~~~~~vv~ 191 (390) T 6FPJ_A 117 -LKGAILSLLSYYKWEKFVYLYDT-ERGFSVLQAIMEAAVQN-NWQVTARSVGNI-KDVQEFRRIIEEMDR-RQEKRYLI 191 (390) T ss_dssp -CHHHHHHHHHHTTCCEEEEEECS-TTCSHHHHHHHHHHHHH-TCEEEEEECTTC-CSHHHHHHHHHHHHH-TTCCEEEE T ss_pred -HHHHHHHHHHHcCCcEEEEEEeC-cccHHHHHHHHHHHHhC-CCeEEEEEeCCC-CCHHHHHHHHHHHhh-cCCcEEEE Confidence 46788888888899999999954 67777777777777664 345433211110 122456667777763 57898888 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) ......+..+++++++.|+.. .+.|+..+.+...... ........+...+.... ...+....| T Consensus 192 ~~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~~---------------~~~~~~~~f 255 (390) T 6FPJ_A 192 DCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILL-ERVMHGGANITGFQIVN---------------NENPMVQQF 255 (390) T ss_dssp ESCHHHHHHHHHHHHHHCSSSTTCEEEECCTTGGGCCC-HHHHHTTCEEEEEESCC---------------TTSHHHHHH T ss_pred ECCHHHHHHHHHHHHHhCCccCCeeEEEecCCcchhcH-HHHhcCCccEEEEEEec---------------CCCHHHHHH Confidence 776677788899998888753 3556665433221100 00001111111111000 001111223 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~~~~- 434 (908) .+.+++.+...... .+ ...+..++..+||+++++++|++++...... .....|... T Consensus 256 ~~~~~~~~~~~~~~---------~~----------~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~c~~~~ 316 (390) T 6FPJ_A 256 IQRWVRLDEREFPE---------AK----------NAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANP 316 (390) T ss_dssp HHHHTTSCTTTSTT---------SS----------SSCCCHHHHHHHHHHHHHHHHHHHHHHTTCCCCCC-----CCC-- T ss_pred HHHHHhcCcccCCC---------CC----------CCCCChHHHHHHHHHHHHHHHHHHHHHcCCCcccCCCCCcccCCC Confidence 23232222110000 00 0123456778999999999999988653210 001122110 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ...++..+.+.|++..|.|.+| ++.||++|++. ..+.+++++. +.++.+|.|.....++.....|+ T Consensus 317 ~~~~~~~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~~i~~~~~----~~~~~vg~w~~~~~~~~~~~~~~ 385 (390) T 6FPJ_A 317 AVPWSQGIDIERALKMVQVQGMTG-NIQFDTYGRRTNYTIDVYEMKV----SGSRKAGYWNEYERFVPFSGTKH 385 (390) T ss_dssp CCCCTTHHHHHHHHHTCCEEETTE-EEEECTTSBEESCCEEEEEEET----TEEEEEEEEETTTEEEECC---- T ss_pred CCcchhHHHHHHHHhcCCccCCCc-eEEECCCCceeeeEEEEEEeee----cCcEEEEEEcCCCccccCCCCCC Confidence 0114556778888889999998 89999988886 4778888762 46889999987654444445564 No 52 >3H5L_A putative Branched-chain amino acid ABC; STRUCTURAL GENOMICS, TRANSPORTER, PSI-2, Protein; 1.7A {Ruegeria pomeroyi} Probab=99.61 E-value=2.8e-20 Score=202.99 Aligned_cols=363 Identities=13% Similarity=0.140 Sum_probs=230.2 Template_Neff=11.400 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD-TYALEQSLT 118 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~-~~a~~~~~~ 118 (908) ....++++||++.|.++... ..+.....|++.|++++|+++++. |+++++.+.|+++++ .. +.+ T Consensus 9 ~~~~~~i~Ig~i~~~~~~~~----------~~~~~~~~~~~~a~~~~n~~g~~~-g~~i~~~~~d~~~~~~~~----~~~ 73 (419) T 3H5L_A 9 AQSSDPVVIGCPAPLTGIVA----------ADGIEFQRGIQMAADEINAVGGIL-GRPIELVFADTQSKGVDV----VIQ 73 (419) T ss_dssp ----CCEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHTTTSBT-TBCEEEEEEECTTCCHHH----HHH T ss_pred cCCCCCEEEEEeecCCCCch----------hccHHHHHHHHHHHHHHHHcCCcC-CcceEEEEEeCCCCCHHH----HHH Confidence 45678999999999876431 245678899999999999987654 788999888877653 22 233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA--PELS--DNTRYDFFSR 194 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~--~~l~--~~~~~~~~~~ 194 (908) .+++++. .++++++||+.++.....++..+.+.++|+|++.... +.+. +...++++++ T Consensus 74 ~~~~l~~------------------~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 135 (419) T 3H5L_A 74 SAQRLID------------------RDNASALIAGYNLENGTALHDVAADAGVIAMHANTVAVHDEMVKSDPDRYWGTFQ 135 (419) T ss_dssp HHHHHHH------------------TTCCSEEECSCCSSCSCHHHHHHHHHTCEEEECCCCHHHHHHHHHCTTTCTTEEE T ss_pred HHHHHHH------------------hcCCCEEEecccccchHHHHHHHHHcCCcEEeCCCchhcHHHHhcCccccCceee Confidence 3343332 1578999999888777788888899999999876422 2222 1123567889 Q NP_000836.2 195 VVPPDSYQAQAMVDIVTA--------LGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKII 266 (908) Q Consensus 195 ~~~~~~~~~~~~~~~l~~--------~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~ 266 (908) +.++....+.++++++.+ .+|+++++++.++.++....+.+++.+++. ++++.....+. ....++...+ T Consensus 136 ~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~ 212 (419) T 3H5L_A 136 YDPPETLYGGGFLKFLKDIEDNGEFSRPNNKIAIITGPGIYSVNIANAIRDGAGEY-GYDVSLFETVA--IPVSDWGPTL 212 (419) T ss_dssp SSCCTHHHHHHHHHHHHHHHHTTSCCCSSSEEEEEECSSHHHHHHHHHHHHHGGGG-TCEEEEEEECC--SSCSCCHHHH T ss_pred cCCChhHhHHHHHHHHHHHHhCCCCCCCCCeEEEEECCCHHHHHHHHHHHHHHHHc-CCEEEEEEeeC--CCCCCcHHHH Confidence 999888888888888866 689999999977777888888888888765 45554332222 2234566677 Q NP_000836.2 267 KRLLETPNARAVIMFA-NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 267 ~~l~~~~~~~viv~~~-~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) ++++. .++++|++.+ .+..+..+++++++.|+.. .|++...+...... ........+.+.... + T Consensus 213 ~~i~~-~~~~vv~~~~~~~~~~~~~~~~~~~~g~~~--~~~~~~~~~~~~~~-~~~~~~~~g~~~~~~-----------~ 277 (419) T 3H5L_A 213 AKLRA-DPPAVIVVTHFYPQDQALFMNQFMTDPTNS--LVYLQYGASLAAFR-DIAGDNSVGVTYATV-----------L 277 (419) T ss_dssp HHHHH-SCCSEEEECCCCHHHHHHHHHHHTTSCCSC--EEEECSGGGSHHHH-HHHGGGGTTCEEEES-----------S T ss_pred HHHHh-CCCCEEEEEeCChHHHHHHHHHHhhCCcCc--EEEEechhhhHHHH-HHHcccceeeEEEec-----------c Confidence 77764 5788888775 4566778889988887742 34443322211100 000111222211110 0 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) . ....+....|.+.+++.++. .....++..+|||+++++.+++....... T Consensus 278 ~---~~~~~~~~~f~~~~~~~~~~--------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~~~- 327 (419) T 3H5L_A 278 G---TLQDEMGDAFAKAYKERYGD--------------------------LSSTASGCQTYSALYAYSIAAALAGGPGA- 327 (419) T ss_dssp C---CCSSHHHHHHHHHHHHHHCT--------------------------TSCHHHHHHHHHHHHHHHHHHHHTTSCCC- T ss_pred C---cCCCHHHHHHHHHHHHHHCC--------------------------CCCCcCcchHHHHHHHHHHHHHHcCCCCC- Confidence 0 00011122233333322211 01123466799999999999876543210 Q NP_000836.2 426 GYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 426 ~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) + ....++..+.++|++..|.|.+| ++.||++|++...+.+..++.. ...+..|+.|.. T Consensus 328 -----~--~~~~~~~~l~~~l~~~~f~g~~G-~v~f~~~g~~~~~~~~~~~~~~--~~~~~~v~q~~~ 385 (419) T 3H5L_A 328 -----P--YDDVQNKAVADRLRSLIFRGPVG-TMRFHADTQSAWSYPTETNDPS--LGMPHIFSQIFD 385 (419) T ss_dssp -----T--TCHHHHHHHHHHHHHCEEEETTE-EEEBCTTTCBBCEETTTCSCTT--SSEECEEEECCC T ss_pred -----C--CCcccHHHHHHHHHhCCcccCCe-eEEeCCCCcccCCCCCcCCCcc--cccceEEEEeec Confidence 0 01234567888899889999999 8999999988777777776632 245778888886 No 53 >3H5L_B putative Branched-chain amino acid ABC; STRUCTURAL GENOMICS, TRANSPORTER, PSI-2, Protein; 1.7A {Ruegeria pomeroyi} Probab=99.61 E-value=2.8e-20 Score=202.99 Aligned_cols=363 Identities=13% Similarity=0.140 Sum_probs=232.5 Template_Neff=11.400 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD-TYALEQSLT 118 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~-~~a~~~~~~ 118 (908) ....++++||++.|.++... ..+.....|++.|++++|+++++. |+++++.+.|+++++ .. +.+ T Consensus 9 ~~~~~~i~Ig~i~~~~~~~~----------~~~~~~~~~~~~a~~~~n~~g~~~-g~~i~~~~~d~~~~~~~~----~~~ 73 (419) T 3H5L_B 9 AQSSDPVVIGCPAPLTGIVA----------ADGIEFQRGIQMAADEINAVGGIL-GRPIELVFADTQSKGVDV----VIQ 73 (419) T ss_dssp CCCSSCEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHHTTTBT-TBCEEEEEEECTTCCHHH----HHH T ss_pred cCCCCCEEEEEeecCCCCch----------hccHHHHHHHHHHHHHHHHcCCcC-CcceEEEEEeCCCCCHHH----HHH Confidence 45678999999999876431 245678899999999999987654 788999888877653 22 233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA--PELS--DNTRYDFFSR 194 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~--~~l~--~~~~~~~~~~ 194 (908) .+++++. .++++++||+.++.....++..+.+.++|+|++.... +.+. +...++++++ T Consensus 74 ~~~~l~~------------------~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 135 (419) T 3H5L_B 74 SAQRLID------------------RDNASALIAGYNLENGTALHDVAADAGVIAMHANTVAVHDEMVKSDPDRYWGTFQ 135 (419) T ss_dssp HHHHHHH------------------TTCCSEEECSCCSSCSCHHHHHHHHHTCEEEECCCCHHHHHHHHHCTTTCTTEEE T ss_pred HHHHHHH------------------hcCCCEEEecccccchHHHHHHHHHcCCcEEeCCCchhcHHHHhcCccccCceee Confidence 3343332 1578999999888777788888899999999876422 2222 1123567889 Q NP_000836.2 195 VVPPDSYQAQAMVDIVTA--------LGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKII 266 (908) Q Consensus 195 ~~~~~~~~~~~~~~~l~~--------~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~ 266 (908) +.++....+.++++++.+ .+|+++++++.++.++....+.+++.+++. ++++.....+. ....++...+ T Consensus 136 ~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~ 212 (419) T 3H5L_B 136 YDPPETLYGGGFLKFLKDIEDNGEFSRPNNKIAIITGPGIYSVNIANAIRDGAGEY-GYDVSLFETVA--IPVSDWGPTL 212 (419) T ss_dssp SSCCTHHHHHHHHHHHHHHHHTTSCCCSSSEEEEEECSSHHHHHHHHHHHHHGGGG-TCEEEEEEECC--SSCSCCHHHH T ss_pred cCCChhHhHHHHHHHHHHHHhCCCCCCCCCeEEEEECCCHHHHHHHHHHHHHHHHc-CCEEEEEEeeC--CCCCCcHHHH Confidence 999888888888888866 689999999977777888888888888765 45554332222 2234566677 Q NP_000836.2 267 KRLLETPNARAVIMFA-NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 267 ~~l~~~~~~~viv~~~-~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) ++++. .++++|++.+ .+..+..+++++++.|+.. .|++...+...... ........+.+.... + T Consensus 213 ~~i~~-~~~~vv~~~~~~~~~~~~~~~~~~~~g~~~--~~~~~~~~~~~~~~-~~~~~~~~g~~~~~~-----------~ 277 (419) T 3H5L_B 213 AKLRA-DPPAVIVVTHFYPQDQALFMNQFMTDPTNS--LVYLQYGASLAAFR-DIAGDNSVGVTYATV-----------L 277 (419) T ss_dssp HHHHH-SCCSEEEECCCCHHHHHHHHHHHTTSCCSC--EEEECSGGGSHHHH-HHHGGGGTTCEEEES-----------S T ss_pred HHHHh-CCCCEEEEEeCChHHHHHHHHHHhhCCcCc--EEEEechhhhHHHH-HHHcccceeeEEEec-----------c Confidence 77764 5788888775 4566778889988887742 34443322211100 000111222211110 0 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) . ....+....|.+.+++.++. .....++..+|||+++++.+++....... T Consensus 278 ~---~~~~~~~~~f~~~~~~~~~~--------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~~~- 327 (419) T 3H5L_B 278 G---TLQDEMGDAFAKAYKERYGD--------------------------LSSTASGCQTYSALYAYSIAAALAGGPGA- 327 (419) T ss_dssp C---CCSSHHHHHHHHHHHHHHCT--------------------------TSCHHHHHHHHHHHHHHHHHHHHTTSCCC- T ss_pred C---cCCCHHHHHHHHHHHHHHCC--------------------------CCCCcCcchHHHHHHHHHHHHHHcCCCCC- Confidence 0 00011122233333322211 01123466799999999999876543210 Q NP_000836.2 426 GYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 426 ~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) + ....++..+.++|++..|.|.+| ++.||++|++...+.+..++.. ...+..|+.|.. T Consensus 328 -----~--~~~~~~~~l~~~l~~~~f~g~~G-~v~f~~~g~~~~~~~~~~~~~~--~~~~~~v~q~~~ 385 (419) T 3H5L_B 328 -----P--YDDVQNKAVADRLRSLIFRGPVG-TMRFHADTQSAWSYPTETNDPS--LGMPHIFSQIFD 385 (419) T ss_dssp -----T--TCHHHHHHHHHHHHHCEEEETTE-EEEBCTTTCBBCEETTTCSCTT--SSEECEEEECSC T ss_pred -----C--CCcccHHHHHHHHHhCCcccCCe-eEEeCCCCcccCCCCCcCCCcc--cccceEEEEeec Confidence 0 01234567888899889999999 8999999988777777776632 245778888886 No 54 >5KCA_A Cerebellin-1,Cerebellin-1,Cerebellin-1,Glutamate receptor ionotropic, delta-2; Cerebellin, ionotropic glutamate receptor (iGluR); 3.1A {Homo sapiens} Probab=99.60 E-value=4.6e-20 Score=221.09 Aligned_cols=382 Identities=16% Similarity=0.223 Sum_probs=236.7 Template_Neff=10.400 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI-LDTCSRDTYALEQSLT 118 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~-~d~~~~~~~a~~~~~~ 118 (908) .....+++||+++|.++ .....|+++|++++|+++++++++++++++ .|++.++..+.+ T Consensus 452 ~~~~~~i~IG~i~~~sg----------------~~~~~a~~~A~~~iN~~~~~~~g~~l~~~~~~D~~~~~~~a~~---- 511 (878) T 5KCA_A 452 GGSDSIIHIGAIFDESA----------------KKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQ---- 511 (878) T ss_pred CCCCCCeEEEEEeCCCh----------------HHHHHHHHHHHHHHHhCCCCCCCCeEEEEEEEeCCCCHHHHHH---- Confidence 34467889999998764 246689999999999987777788899888 888776543333 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAP-------ELSDNTRYDF 191 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~-------~l~~~~~~~~ 191 (908) .+++++. ++++++||+.++.....++.+++..++|+|++....+ .+++...+++ T Consensus 512 ~~~~l~~-------------------~~v~aviG~~~s~~~~~v~~~~~~~~ip~is~~~~~~~~~~~~~~l~~~~~~~~ 572 (878) T 5KCA_A 512 EACELMN-------------------QGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDD 572 (878) T ss_pred HHHHHHH-------------------cCCCEEECCCCChhHHHHHHHHHHhCCCEEccCCCCCCCCCCCcccCCCCCCCc Confidence 3333332 4788999998887777888889999999999876554 3443345788 Q NP_000836.2 192 FSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL- 270 (908) Q Consensus 192 ~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~- 270 (908) +++..+++..+++++++++++++|+++++++ +++++....+.+++.+++. ++++.....++ ....++...+++++ T Consensus 573 ~~~~~~~~~~~~~al~~~l~~~~w~~v~Iv~-d~~~g~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~~~~ 648 (878) T 5KCA_A 573 YTLSVRPPVYLHDVILRVVTEYAWQKFIIFY-DSEYDIRGIQEFLDKVSQQ-GMDVALQKVEN--NINKMITTLFDTMRI 648 (878) T ss_pred eeecCCCHHHHHHHHHHHHHHhCCCEEEEEe-cChhhHHHHHHHHHHHHHc-CCEEEEeeecC--CCCCCChHHHHHHHH Confidence 9999998888899999999889999999777 4567777778888777765 45554332222 11122222222221 Q NP_000836.2 271 ---E--TPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRY 344 (908) Q Consensus 271 ---~--~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~ 344 (908) + ..++++|++......+..+++++++.++.. ++.|+..+.+...............+......... T Consensus 649 ~~l~~~~~~~~vIil~~~~~~~~~~l~~a~~~g~~~~~~~~i~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~-------- 720 (878) T 5KCA_A 649 EELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFP-------- 720 (878) T ss_pred HHHHhhccCCcEEEEeCCHHHHHHHHHHHHHcCCCCCCcEEEEeccccCCcchhHHHHHhccceeeecCCCC-------- Confidence 0 136788888777777888999999888753 46777765443221100000000111111100000 Q NP_000836.2 345 FRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLC 424 (908) Q Consensus 345 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~ 424 (908) .........+.+.+.+.+. .|...... ...+..++..+|||++++++|++++....+ T Consensus 721 -----~~~~~~~~~~~~~~~~~~~--------------~~~~~~~~----~~~~~~~~~~~yDAv~l~a~al~~~~~~~~ 777 (878) T 5KCA_A 721 -----VPQNISQRCFRGNHRISST--------------LCDPKDPF----AQNMEISNLYIYDTVLLLANAFHKKLEDRK 777 (878) T ss_pred -----CCCChhHHhhhhhhccCCC--------------CCCCCCCC----CCCccchHHHHHHHHHHHHHHHHHHHhcCC Confidence 0000001111111111110 11100000 012345677899999999999999875432 Q NP_000836.2 425 PGY--IGLCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITN-KSTEYKVIGHWTNQLH 496 (908) Q Consensus 425 ~~~--~~~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~-~~~~~~~Vg~~~~~~~ 496 (908) ... ...|... ...++..+.+.|++..|.|.+| .+.||++|++. ..+.|++++... +...+++||.|..... T Consensus 778 ~~~~~~~~c~~~~~~~~~~~~~l~~~l~~~~f~G~~G-~i~fd~~g~r~~~~~~I~~~~~~~~~~~~~~~Vg~w~~~~g 855 (878) T 5KCA_A 778 WHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTG-ELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTG 855 (878) T ss_pred CCCCCCCccCCCCCCCCcCHHHHHHHHhcCeeecCCc-cEEecCCCCcCCCeEEEEEEecCCCCCCceEEEEEEeCCCC Confidence 110 1122110 1124556788888889999998 89999999964 578888887411 1257899999997643 No 55 >4XFK_A BrovA.17370.a; transport protein, Structural Genomics, Seattle; 1.3A {Brucella ovis} Probab=99.60 E-value=5.4e-20 Score=199.14 Aligned_cols=355 Identities=14% Similarity=0.144 Sum_probs=229.2 Template_Neff=11.000 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) ...++||++.|++++.. ..+..+..|+++|++++|+.+++. |+++++.+.|+++++..+ .+.+++ T Consensus 9 ~~~~~ig~~~plsG~~~----------~~g~~~~~g~~~a~~~iN~~gg~~-g~~i~~~~~d~~~~~~~~----~~~~~~ 73 (399) T 4XFK_A 9 AEPLKIALVETLSGPQA----------STGLLYRAAVLYQLGKINEAGGFN-GEKIQILEYDNQGGPVGA----ADRVKA 73 (399) T ss_dssp CCCCEEEEEECCSSTTC----------HHHHHHHHHHHHHHHHHHHTTCBT-TBCCEEEEEECCSHHHHH----HHHHHH T ss_pred CCCceEEEEcCCCCCch----------HHHHHHHHHHHHHHHHHHHcCCcC-CeeEEEEEEeCCCChHHH----HHHHHH Confidence 45789999999998642 356788999999999999887653 788999999987764432 233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRL-------FKIPQISYASTAPELSDNTRYDFFSRV 195 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~-------~~iP~Is~~~~~~~l~~~~~~~~~~~~ 195 (908) ++. ++++++||+.++.....++..++. .++|+|++.+..+.+.+...+++++++ T Consensus 74 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~ 134 (399) T 4XFK_A 74 AIA-------------------DGAQIIVQGSSSAVAGQITEDVRKYNLRNKGKEVLYLNLGAEALELTGSKCHFYHFRF 134 (399) T ss_dssp HHH-------------------TTCSEEEECSCHHHHHHHHHHHHHHHHHSTTSCCEEEESSCCCGGGGTTTCCTTEEEC T ss_pred HHH-------------------cCCCEEEEcCChHHHHHHHHHHHHhccccCCCceeEEeccccchHhcCCCCCceEEEc Confidence 332 478899998877766666666665 589999877655544332246788999 Q NP_000836.2 196 VPPDSYQAQAMVDIVTALGW--NYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETP 273 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~~~--~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~ 273 (908) .++....+.++++++.+.+| +++++++.+++++....+.+++.+++. ++++.....+.. ....++...+++++. . T Consensus 135 ~~~~~~~~~~~~~~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~-~~~~~~~~~~~~i~~-~ 211 (399) T 4XFK_A 135 SPNAAIRFKTVAQGMKDKGILGERAYSINQNYSWGVDVENTVVANAKEI-GYEVVDKTLHEV-NKIQDFSPYVAKIQA-A 211 (399) T ss_dssp SCCHHHHHHHHHHHHHHHTCCCSEEEEEEESSHHHHHHHHHHHHHCCCC-CCEEEEEEEECS-SCCSCCHHHHHHHHH-T T ss_pred CCcHHHHHHHHHHHHHHcCCCCceEEEEeeCChhhhhHHHHHHHHHHHc-CCEEeeeeeccc-ccCcccHHHHHHHHH-C Confidence 99988888899999888888 899999977778888888888887765 355543322221 123456667777764 5 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANN 353 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~ 353 (908) ++|+|++...+..+..+++++++.|+.. .|+. . +...............+.+...... .. ... T Consensus 212 ~~~~iv~~~~~~~~~~~~~~~~~~g~~~--~~~~-~-~~~~~~~~~~~~~~~~~~~~~~~~~----------~~---~~~ 274 (399) T 4XFK_A 212 NVDTVFTGNWSNDLLLLMKAASGAGLKA--KFAT-S-FLDQPGNIGNAGAIAEGHIVSTPFN----------PE---ANG 274 (399) T ss_dssp TCSEEEECCCTHHHHHHHHHHHHHTCCS--EEEE-S-STTSTTHHHHHGGGCTTCEEEESCC----------TT---TTH T ss_pred CCCEEEEecCCHHHHHHHHHHHHcCCcc--cccc-c-cccCcchHHhchHhhcCcEEecCCC----------cc---cCC Confidence 8899988877777888999998888753 3443 2 2111100000111122322211100 00 001 Q NP_000836.2 354 RRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPR 433 (908) Q Consensus 354 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~ 433 (908) +....|.+.+.+.++ ..++.++..+|||+++++++++++.... T Consensus 275 ~~~~~f~~~~~~~~~---------------------------~~p~~~~~~~yda~~~l~~al~~~~~~~---------- 317 (399) T 4XFK_A 275 EASMAFAEDYKKVTG---------------------------HYPSYVEPAAVFGLQLFGEALKNVKPGE---------- 317 (399) T ss_dssp HHHHHHHHHHHHHHS---------------------------SCCCTTHHHHHHHHHHHHHHHHHSCCCS---------- T ss_pred HHHHHHHHHHHHHHC---------------------------CCCCchHHHHHHHHHHHHHHHHhcCCCC---------- Confidence 111222222222211 1123467789999999999998875311 Q NP_000836.2 434 MSTIDGKELLGYIRAVNFNGSAGTPVTFNE-NGDAPGRYDIFQYQITNKSTEYKVIG-HWTN 493 (908) Q Consensus 434 ~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~-~G~~~~~~~i~~~~~~~~~~~~~~Vg-~~~~ 493 (908) ...+++.+.++|++..|.|.+| .+.|+. ++++...+.+.+++.. +....+| .|.. T Consensus 318 -~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~i~~~~~~---~~~~~~g~~~~~ 374 (399) T 4XFK_A 318 -GKINTTDIALAIENASVKTPMG-DYSMRSDDHQAKFPMVVQEVSKK---ARIKADGTEYGF 374 (399) T ss_dssp -SCCCHHHHHHHHHHCEEEETTE-EEEECTTTCBEECCEEEEEEETT---CSSBSTTSSCEE T ss_pred -CCCCHHHHHHHHHhCceecCce-eeEeCCCCCeeeecEEEEEEcCc---ccccCCCCccee Confidence 0124567788888888999988 899997 5555567788888732 3455667 6653 No 56 >5KC9_A Glutamate receptor ionotropic, delta-1; ionotropic glutamate receptor (iGluR), neurotransmission; HET: BU1, CL, NAG, EDO, PG4; 2.3A {Mus musculus} Probab=99.60 E-value=5.6e-20 Score=201.24 Aligned_cols=372 Identities=16% Similarity=0.202 Sum_probs=224.4 Template_Neff=11.600 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTFV 120 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~~ 120 (908) .+.+++||+++|.++. ....|+++|++++|+++++++++++++.+.|++ +++..+. +.+ T Consensus 3 ~~~~i~Ig~l~p~~g~----------------~~~~~~~~A~~~in~~~~~~~~~~l~~~~~d~~~~~~~~~~----~~~ 62 (428) T 5KC9_A 3 GDSIIHIGAIFEENAA----------------KDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAV----QEA 62 (428) T ss_dssp --CEEEEEEEEESSCH----------------HHHHHHHHHHHHHHHHCSSSTTCEEEEEEEEECTTCHHHHH----HHH T ss_pred CCceeEEEEeecCCCh----------------HHHHHHHHHHHHHhcCCccCCCceEEEEEEEecCCCHHHHH----HHH Confidence 4578999999998752 466899999999999877766788998888864 4433222 233 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) .+++. ++++++||+.++..+..++.++...++|+|++.. ++.+. ..+++++++.++.. T Consensus 63 ~~l~~-------------------~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~-~~~~~--~~~~~~~~~~~~~~ 120 (428) T 5KC9_A 63 CDLMT-------------------QGILALVTSTGCASANALQSLTDAMHIPHLFVQR-NPGGS--PRTACHLNPSPDGE 120 (428) T ss_dssp HHHHH-------------------TCCSCEEEECCHHHHHHHHHHHHHHTCCEEECCC-CSTTS--CCCCCCCCCCCTTC T ss_pred HHHHh-------------------cCeeEEEcCCChHHHHHHHHHHHhcCCCEeeeec-CCCCC--CCcccceecCCCCC Confidence 33332 5789999998887777888889999999999854 33332 23456666555544 Q NP_000836.2 201 ----------YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFE------- 263 (908) Q Consensus 201 ----------~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~------- 263 (908) ..+.++++++++++|+++++++.+ +++....+.+.+.+++. ++++....... .+..++. T Consensus 121 ~~~~~~~p~~~~~~a~~~~l~~~~~~~v~il~~~-~~g~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~~~ 196 (428) T 5KC9_A 121 AYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDS-EYDIRGLQSFLDQASRL-GLDVSLQKVDK--NISHVFTSLFTTMK 196 (428) T ss_dssp CCEEECSCCCCHHHHHHHHHHHTTCSEEEEEECT-TCCGGGGHHHHHHHHHT-TCEEEEEECCS--CHHHHHHHHHHHSC T ss_pred cceeccCCChhHHHHHHHHHHHcCCcEEEEEEcC-hHHHHHHHHHHHHHHhh-CCcEEEEEcCC--CcccccHHHHHHhh Confidence 578888998888899999999954 46777777777777665 35554322111 1111222 Q NP_000836.2 264 -KIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEG-AVTILPKRASIDG 340 (908) Q Consensus 264 -~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g-~~~~~~~~~~~~~ 340 (908) ..+++++. .+++|++......+..+++++++.|+.. .+.|+..+.+...... ........+ ...+.. T Consensus 197 ~~~l~~l~~--~~~~iv~~~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~------- 266 (428) T 5KC9_A 197 TEELNRYRD--TLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEI-LDLVHSALGRMTVVRQ------- 266 (428) T ss_dssp HHHHHHHHH--HTTEEEEESCHHHHHHHHHHHHHTTCCCTTCEEEEECSCCCHHHH-HHHHHHCSSEEEEEEE------- T ss_pred HHHHHHHhh--cccEEEEECCHHHHHHHHHHHHHcCCCCCCeEEEEecCCcCCccH-HHHHhccCcceEEEEe------- Confidence 44555542 3788877777777888999998888754 3566665432211100 000000111 111100 Q NP_000836.2 341 FDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH 420 (908) Q Consensus 341 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~ 420 (908) + . ...+....|.+.+.+.+.. .|..... ....+..++..+|||++++++|++++. T Consensus 267 ---~-~----~~~~~~~~f~~~~~~~~~~-------------~~~~~~~----~~~~~~~~~~~~yda~~~~~~al~~~~ 321 (428) T 5KC9_A 267 ---I-F----PSAKDNQKCMRNNHRISSL-------------LCDPQEG----YLQMLQISNLYLYDSVLMLANAFHRKL 321 (428) T ss_dssp ---C-C----CCCCCTTTTEETTEECCST-------------TTSCCTT----TGGGSCHHHHHHHHHHHHHHHHHHHHH T ss_pred ---c-C----CCchHHHHHHHHHHHchhh-------------hcCCCCC----cchhcccHHHHHHHHHHHHHHHHHHHH Confidence 0 0 0011112222223222210 0100000 001234567889999999999999886 Q NP_000836.2 421 KDLCPG--YIGLCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITN-KSTEYKVIGHWTN 493 (908) Q Consensus 421 ~~~~~~--~~~~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~-~~~~~~~Vg~~~~ 493 (908) ...+.. ....|... ...++..+.+.|++..|.|.+| .+.|+++|++. ..+.+++++... +...++.||.|+. T Consensus 322 ~~~~~~~~~~~~c~~~~~~~~~~~~~l~~~l~~~~~~g~~G-~v~f~~~g~~~~~~~~i~~~~~~~~~~~~~~~vg~w~~ 400 (428) T 5KC9_A 322 EDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTG-VMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDS 400 (428) T ss_dssp HTTCCCCCCCCCSSSTTCCCCTTHHHHHHHHHTCEEEETTE-EEECCTTSBCCCCEEEEEEEEEETTTEEEEEEEEEEET T ss_pred HcCCCCCcCCCcccCCCCCCCcchHHHHHHHHcCeeecccc-eEEECCCCCCCeEEEEEEeceeeccCCCCeEEEEEEeC Confidence 532110 01122110 1124556778888888999999 89999999886 578888877421 1256899999997 Q NP_000836.2 494 QL 495 (908) Q Consensus 494 ~~ 495 (908) .. T Consensus 401 ~~ 402 (428) T 5KC9_A 401 EK 402 (428) T ss_dssp TT T ss_pred CC Confidence 64 No 57 >6JFY_A Glutamate receptor ionotropic, kainate 3; Glutamate receptor, Kainate, SYM, MEMBRANE; 7.4A {Rattus norvegicus} Probab=99.58 E-value=1.1e-19 Score=216.68 Aligned_cols=373 Identities=15% Similarity=0.201 Sum_probs=238.9 Template_Neff=11.400 Q NP_000836.2 43 DGDIILGGLFPVHAK-GERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTFV 120 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~-~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~~ 120 (908) +++++||+++|.++. .. ..+.....|+++|++++|+.+++++|+++++++.|++ +++..+ .+.+ T Consensus 2 ~~~i~ig~~~~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~~~~~~g~~l~l~~~d~~~~~~~~~----~~~~ 67 (809) T 6JFY_A 2 PHVIRIGGIFEYADGPNA----------QVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEA----TKKA 67 (809) T ss_dssp -CEEECCBCEEESSGGGC----------SSCCHHHHHHHHHHHHHHHCTTSCSSCEEECCCCEEESSCHHHH----HHHH T ss_pred CceeEEEEeeecCCCCcc----------ccccHHHHHHHHHHHHHhcCCccCCCceeEEeeEecCCCChHHH----HHHH Confidence 468999999999864 21 3567889999999999999887777889999999977 453322 2233 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. +++++++|+.++..+.++++.++..++|++++.++++.+.+ ..++++++.|++. T Consensus 68 ~~l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~ 126 (809) T 6JFY_A 68 CDQLA-------------------LGVVAIFGPSQGSTTNAVQSICNALEVPHIQLRWKHHPLDN--KDTFYVNLYPDYA 126 (809) T ss_dssp HHHHH-------------------HCCSCCBCCSCTTTHHHHHHHHHHTTCCCBCCSCCCCCSSC--CCSSCCCCCCCHH T ss_pred HHHHh-------------------cCccEEECCCCchHHHHHHHHHHHhCCCEEEEEecCCCCCC--CCeEEEEeeCCHH Confidence 33322 47899999888877778888889999999998876665443 2577899999999 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ..++++++++++++|+++++++ +++++....+.+++.+++. ++++.... +. .+..++...++++++ .++|+|++ T Consensus 127 ~~~~~~~~~l~~~~~~~v~iv~-~~~~~~~~~~~~~~~~~~~-g~~v~~~~-~~--~~~~~~~~~~~~l~~-~~~~~vv~ 200 (809) T 6JFY_A 127 SLSHAILDLVQSLKWRSATVVY-DDSTGLIRLQELIMAPSRY-NIRLKIRQ-LP--IDSDDSRPLLKEMKR-GREFRIIF 200 (809) T ss_dssp HHHHHHHHHHHHHTCSCCCEEE-CSTHHHHHHHHHHTGGGTS-CCCCCEEE-CC--SSSCCCHHHHHHHHH-TTCCEEEE T ss_pred HHHHHHHHHHHHcCCCEEEEEE-cCCchHHHHHHHhhCcccc-CeeEEEEe-CC--CCCcccHHHHHHHHh-CCceEEEE Confidence 9999999999888999999999 6778888888888888775 46665433 22 223456677777763 57899888 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) .+....+..++++++++|+.. .+.|+..+.+...... ........+...... + . ...+....| T Consensus 201 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~----------~-~----~~~~~~~~f 264 (809) T 6JFY_A 201 DCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDL-EPYRYSGVNLTGFRI----------L-N----VDNPHVSAI 264 (809) T ss_dssp CSCHHHHHHHHHHHHHTTCCCTTCEEECCSSCTTSSCC-HHHHTTCCEEECCBC----------S-C----TTCHHHHHH T ss_pred ECCHHHHHHHHHHHHHccCcCCCeEEEEeeCCcccCCC-cccccCCceeEEEEE----------e-e----CCCchHHHH Confidence 877777888999999888754 3456654432211100 000000011110000 0 0 001111122 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM-STID 438 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~-~~~~ 438 (908) .+.+++.+..... ..|... ....++.++..+|||++++++|++++....+.. ..|... ...+ T Consensus 265 ~~~~~~~~~~~~~---------~~~~~~------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~--~~~~~~~~~~~ 327 (809) T 6JFY_A 265 VEKWSMERLQAAP---------RAESGL------LDGVMMTDAALLYDAVHIVSVTYQRAPQMTVNS--LQCHRHKAWRF 327 (809) T ss_dssp HHHHHHHCCC--------------------------CCCCHHHHHHHHHHHHHHHHHHSSCCCCCCC--CCSSSCCCCHH T ss_pred HHHhhHHHHhhCC---------cccCCc------CCCCcchHHHHHHHHHHHHHHHHHhCcCCCCcc--ccccccccccc Confidence 2222222110000 000000 001234567889999999999999987532111 111111 1124 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDA-P-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~-~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ++.+.++|++..|.|.+| ++.||++|++ . ..+.+.+++ ++.++.+|.|.+. T Consensus 328 ~~~l~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~~i~~~~----~~~~~~v~~~~~~ 380 (809) T 6JFY_A 328 GGRFMNFIKEAQWEGLTG-RIVFNKTSGLRTDFDLDIISLK----EDGLEKVGVWSPA 380 (809) T ss_dssp HHHHHHHHHTCCEEETTE-EECCBTTTTBCCCCCEEEEEEE----TTEEEEEEEEETT T ss_pred hhHHHHHHHHhccCCCcc-cEEEecCCCceeeeEEEEEEec----ccCceEeEEEeCC Confidence 567888888889999988 8999986443 3 266777776 2568888988764 No 58 >4GPA_A Glutamate receptor 4; PBP fold, GLUTAMATE RECEPTOR, LIGAND-GATED; HET: NAG; 2.25A {Rattus norvegicus} Probab=99.58 E-value=1.1e-19 Score=196.06 Aligned_cols=361 Identities=14% Similarity=0.180 Sum_probs=224.0 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLL-SNITLGVRI-LDTCSRDTYALEQSLTFV 120 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il-~g~~l~~~~-~d~~~~~~~a~~~~~~~~ 120 (908) +++++||+++|.++. ....|+++|++++|+++++. +++++++.+ .|+.+++.. ..+.+ T Consensus 3 ~~~i~ig~~~~~~~~----------------~~~~~~~~a~~~~n~~~~~~~~~~~l~~~~~~~~~~~~~~----~~~~~ 62 (389) T 4GPA_A 3 PSSVQIGGLFIRNTD----------------QEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFA----VTNAF 62 (389) T ss_dssp CSEEEEEEEECTTCH----------------HHHHHHHHHHHHHHTCSCTTTCSSEEEEEEEECSSCCHHH----HHHHH T ss_pred CCceeeeeEEecCCH----------------HHHHHHHHHHHHHhcCCCcCCCCceeeeeeeecCCCCHHH----HHHHH Confidence 568999999998752 56789999999999876542 346777664 344444332 22333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) .+++. +++++|||+.++.....++.++...+||+|++.+..+ ..+++++++.++ T Consensus 63 ~~~~~-------------------~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~-- 116 (389) T 4GPA_A 63 CSQYS-------------------RGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTE-----GESQFVLQLRPS-- 116 (389) T ss_dssp HHHHH-------------------TTCSEEEECCCTTTHHHHHHHHHHTTCEEEECSCCCS-----SCCSSEEECSCC-- T ss_pred HHHHh-------------------hCeeEEEeCCCchHHHHHHHHHHHcCCcEEeCCCCCC-----CCcccEEEeecc-- Confidence 33332 4788999988777777788888999999999876543 236788888887 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) .+.++++++++++|+++++++.++ ++....+.+++.+++. ++++....... .+..++...+++++. .++++|++ T Consensus 117 -~~~~~~~~~~~~~~~~v~il~~~~-~~~~~~~~~~~~~~~~-~~~v~~~~~~~--~~~~~~~~~~~~i~~-~~~~~vv~ 190 (389) T 4GPA_A 117 -LRGALLSLLDHYEWNCFVFLYDTD-RGYSILQAIMEKAGQN-GWHVSAICVEN--FNDVSYRQLLEELDR-RQEKKFVI 190 (389) T ss_dssp -CHHHHHHHHHHTTCCEEEEEECST-TCSHHHHHHHHHHHTT-TCEEEEEECTT--CCHHHHHHHHHHHHH-HTCCEEEE T ss_pred -hHHHHHHHHHHcCCcEEEEEEcCh-hHHHHHHHHHHHHhhc-CCeEEEEEeeC--CCCccHHHHHHHHHh-cCCcEEEE Confidence 567788888888999999999655 7777778888877765 35554321111 122345566777763 57898888 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) .+....+..+++++++.|+.. .+.|+..+.+...... ........+...... .. ...+....| T Consensus 191 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~-----------~~----~~~~~~~~f 254 (389) T 4GPA_A 191 DCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISL-ERFIHGGANVTGFQL-----------VD----FNTPMVTKL 254 (389) T ss_dssp ECCHHHHHHHHHHHHHHTCSBTTCEEEECSSBGGGSCC-HHHHHHBCEEEEEEC-----------SC----TTSHHHHHH T ss_pred ECCHHHHHHHHHHHHHcCCCCCCeEEEEEcCCccccCh-HHhccCCeeEEEEEE-----------ec----CCCHHHHHH Confidence 776667788999998888753 3556665432211100 000000111111100 00 001111223 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~~~~- 434 (908) .+.|++.++.. |... ...+..++..+||++++++++++++....+. .....|... T Consensus 255 ~~~~~~~~~~~-------------~~~~-------~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~c~~~~ 314 (389) T 4GPA_A 255 MDRWKKLDQRE-------------YPGS-------ETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANP 314 (389) T ss_dssp HHHHTTSCTTT-------------STTT-------TSCCCHHHHHHHHHHHHHHHHHHHHHHTTCCCCCTTCCCCTTCSS T ss_pred HHHHHHhcccc-------------CCCC-------CCCCCcHHHHHHHHHHHHHHHHHHHHhCCCCcccCCCCCccccCC Confidence 33333322210 0000 0113456778999999999999987643211 001122210 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQLH 496 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~~ 496 (908) ...++..+.+.|++..|.|.+| ++.|+++|++.. .+.+++++ ++.++.||.|+.... T Consensus 315 ~~~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~g 374 (389) T 4GPA_A 315 AAPWGQGIDMERTLKQVRIQGLTG-NVQFDHYGRRVNYTMDVFELK----STGPRKVGYWNDMDK 374 (389) T ss_dssp CCCCTTHHHHHHHHHTCEEEETTE-EEEBCTTSCBCSCEEEEEEEE----TTEEEEEEEEETTTE T ss_pred CCcccchHHHHHHHhcCCcccCCe-eeEECCCCceeeeeEEEEEcc----cCCCEEeEEEeCCcc Confidence 1124556778888888999988 899999898875 78888887 246889999987643 No 59 >5EWM_A NMDA glutamate receptor subunit, Glutamate; Glutamate receptor, allosteric modulator, GluN2B; HET: MAN, 5SM, NAG, BMA; 2.76A {Xenopus laevis} Probab=99.58 E-value=1.2e-19 Score=195.95 Aligned_cols=351 Identities=18% Similarity=0.242 Sum_probs=221.3 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.+ ....|+++|++++|+.++ +.++++++...|+..++..+. +.+.+ T Consensus 2 ~~~i~Ig~~~~~~------------------~~~~~~~~a~~~~n~~~~-~~~~~l~~~~~d~~~~~~~~~----~~~~~ 58 (390) T 5EWM_A 2 PKIVNIGAVLSTK------------------KHEQIFREAVNQANKRHF-TRKIQLQATSVTHRPNAIQMA----LSVCE 58 (390) T ss_dssp CEEEEEEEEESSH------------------HHHHHHHHHHHHHHHHSC-CSSEEEEEEEEECCSSHHHHH----HHCCC T ss_pred CcceEEEEEeCch------------------hHHHHHHHHHHHHhhhcC-CCCceEEEEEecCCCCHHHHH----HHHHH Confidence 4678999999875 245789999999998753 356778877666555433222 22222 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAA-----ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-----~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) ++. .+++++++|+. ++..+..++.++...++|+|++.+..+.+++...+++++++.+ T Consensus 59 ~~~------------------~~~v~~vig~~~~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~ 120 (390) T 5EWM_A 59 DLI------------------SSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVP 120 (390) T ss_dssp CCG------------------GGTEEEEEECCCC-----CCSHHHHHHHHHTTCCEEESSCCCGGGGCTTTSTTEEESSC T ss_pred HHh------------------hcCcEEEEECCCCCCCCCCCchHHHHHHHhcCCCEEEccCCCcccccccccceEEecCC Confidence 221 15788999873 3344455677888899999998887766654445788999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQS-------QKIP------------REPR 258 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~-------~~~~------------~~~~ 258 (908) +...++.++++++++++|+++++++.++.++....+.+++.+++. ++++... ..+. ...+ T Consensus 121 ~~~~~~~~~~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 199 (390) T 5EWM_A 121 PYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEGK-ESKSKKRNYENLDQLSYDNKRGPKADKVLQFEPG 199 (390) T ss_dssp CGGGGHHHHHHHHHHHTCCEEEEEEESSHHHHHHHHHHHHHHCC------------------------CEEEEEEEECTT T ss_pred CHHHHHHHHHHHHHHcCCCEEEEEEecCCcchHHHHHHHHHHhcC-CccccccccccccccccccCCCCCcccceecCCC Confidence 998889999999988999999999987778888888888877765 3443210 0000 0011 Q NP_000836.2 259 PGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRAS 337 (908) Q Consensus 259 ~~~~~~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~ 337 (908) ..++...+++++. .++|+|++.........+++++++.++.. ++.|+..+.+..... ......+.+. T Consensus 200 ~~~~~~~~~~l~~-~~~~~ii~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~~~~~~~~----~~~~~~~~~~------- 267 (390) T 5EWM_A 200 TKNLTALLLEAKE-LEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSA----LRYAPDGIIG------- 267 (390) T ss_dssp CSCCHHHHHHHHH-SSCCEEEEECCHHHHHHHHHHHHHTTCSSTTCEEECCSGGGSHHH----HHHCCTTCEE------- T ss_pred chhHHHHHHHHHh-CCCeEEEEECCHHHHHHHHHHHHHcCCCCCCEEEEEecccCCcch----hhcCCCeEEE------- Confidence 2345556666663 57899888776667778888888877743 456776543321100 0000000000 Q NP_000836.2 338 IDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALH 417 (908) Q Consensus 338 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~ 417 (908) + . . ..+..++..+|||++++++|++ T Consensus 268 ---------------------~-~----~-----------------------------~~~~~~~~~~ydav~~~~~al~ 292 (390) T 5EWM_A 268 ---------------------L-Q----L-----------------------------INGKNESAHISDAVAVVAQAIH 292 (390) T ss_dssp ---------------------E-E----E-----------------------------TTTTCHHHHHHHHHHHHHHHHH T ss_pred ---------------------E-E----E-----------------------------cCCCchHHHHHHHHHHHHHHHH Confidence 0 0 0 0112356789999999999999 Q NP_000836.2 418 NMHKDLCPG-YIGLCPRMS--TIDGKELLGYIRA-VNFNGSAGTPVTFNENGDA-PGRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 418 ~~~~~~~~~-~~~~~~~~~--~~~~~~l~~~l~~-~~f~G~~G~~v~Fd~~G~~-~~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) +.....+.. ....|.... ...+..+.+.+++ ..|.|.+| .+.||++|++ ...+.+++++ .+.++.+|.|+ T Consensus 293 ~~~~~~~~~~~~~~c~~~~~~~~~~~~l~~~l~~~~~~~g~~G-~i~fd~~g~~~~~~~~i~~~~----~~~~~~vg~~~ 367 (390) T 5EWM_A 293 ELFEMENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTG-RIEFNEDGDRKFAQYSIMNLQ----NRKLVQVGIFN 367 (390) T ss_dssp HHTTSSSCCCCCSSSTTCCSCCTTHHHHHHHHHTCCEEEETTE-EEEECTTSCEESCCEEEEEEE----TTEEEEEEEEC T ss_pred HHHhccCCCCCCCccCCCCchhccHHHHHHHHHcCCCCCCCcc-cEEECCCCCcccceEEEEEcC----CCeEEEEEEEe Confidence 987543211 011222110 1134456667765 46888888 8999999998 4788888887 35789999998 Q NP_000836.2 493 NQLH-LKVEDMQWAHR 507 (908) Q Consensus 493 ~~~~-~~~~~i~w~~~ 507 (908) .... .+...+.|+++ T Consensus 368 ~~~~~~~~~~~~w~~~ 383 (390) T 5EWM_A 368 GSYIIQNDRKIIWPGG 383 (390) T ss_dssp SSCEEECSSCCCCSSS T ss_pred CceeeecCCcccCCCC Confidence 6522 22224678653 No 60 >3H6G_A Glutamate receptor, ionotropic kainate 2; MEMBRANE PROTEIN GLYCOPROTEIN, Cell junction; HET: TLA, NAG; 2.697A {Rattus norvegicus} Probab=99.57 E-value=1.2e-19 Score=196.12 Aligned_cols=373 Identities=17% Similarity=0.207 Sum_probs=225.6 Template_Neff=12.000 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCS-RDTYALEQSLTFVQ 121 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~-~~~~a~~~~~~~~~ 121 (908) .++++||+++|.++.. .+.....|+++|++++|+++++++++++++...|+.. +...+ .+.+. T Consensus 2 ~~~i~ig~~~~~~g~~------------~~~~~~~~~~~a~~~~n~~~~~~~~~~l~~~~~d~~~~~~~~~----~~~~~ 65 (395) T 3H6G_A 2 THVLRFGGIFEYVESG------------PMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEA----SKKAC 65 (395) T ss_dssp CEEEEEEEEEEESSSC------------SCCHHHHHHHHHHHHHHHCSSSSSSEEEEEEEEEEETTCHHHH----HHHHH T ss_pred CCeEEEEEEeccCCCC------------CCcHHHHHHHHHHHHHhcCcccCCCCEEEEEEEecCcchhHHH----HHHHH Confidence 4679999999998742 3567889999999999998877767888887777654 32211 11111 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +.. .++++++||+.++.....++.++...++|+|++.+..+.+.. .+++++++.++... T Consensus 66 ~~~-------------------~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~~ 124 (395) T 3H6G_A 66 DQL-------------------SLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDN--KDSFYVSLYPDFSS 124 (395) T ss_dssp HHH-------------------HHCCSCEECCSSHHHHHHHHHHHHHTTCCEEECSCCCCCTTC--CCCSEEEEEECHHH T ss_pred HHH-------------------hcCceEEECCCCHHHHHHHHHHHHHhCCCEEEeecCccccCC--CCceeEEcCCCHHH Confidence 111 147889999988877777888888999999998775544332 35788999999888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++++++++++++|+++++++.+ .++....+.+.+.+++. ++++... .+. ....++...+++++. .+++++++. T Consensus 125 ~~~~~~~~~~~~~~~~v~il~~~-~~~~~~~~~~~~~~~~~-~~~v~~~-~~~--~~~~~~~~~~~~l~~-~~~~~iv~~ 198 (395) T 3H6G_A 125 LSRAILDLVQFFKWKTVTVVYDD-STGLIRLQELIKAPSRY-NLRLKIR-QLP--ADTKDAKPLLKEMKR-GKEFHVIFD 198 (395) T ss_dssp HHHHHHHHHHHTTCSEEEEEESS-THHHHHTHHHHTGGGTS-SCEEEEE-ECC--SSGGGGHHHHHHHHH-TTCCEEEEE T ss_pred HHHHHHHHHHHcCCCEEEEEEeC-CccHHHHHHHHHCcCcc-CceEEEE-ECC--CCCCCcHHHHHHHHh-CCCeEEEEE Confidence 88999999888899999999954 37766677777776664 3554432 222 223355666777753 477888877 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ........+++++++.|+.. .+.|+........... . .....+... ..+..+ . ...+....+. T Consensus 199 ~~~~~~~~~l~~~~~~g~~~~~~~~~~~~~~~~~~~~-~--~~~~~~~~~--------~~~~~~-~----~~~~~~~~~~ 262 (395) T 3H6G_A 199 CSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDV-E--PYRYSGVNM--------TGFRIL-N----TENTQVSSII 262 (395) T ss_dssp SCHHHHHHHHHHHHHTTCCSTTCEEEECCTTGGGBCC-T--TTTTSCCEE--------EEEECS-C----TTSHHHHHHH T ss_pred CCHHHHHHHHHHHHHcCCCcCCeEEEEeeCCcccCcc-h--hhccCCeee--------EEEEEe-c----CCCcchHHHH Confidence 76677788899998888753 2345543211100000 0 000001000 000000 0 0001111222 Q NP_000836.2 361 EFWEENF-GCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM-STID 438 (908) Q Consensus 361 ~~~~~~~-~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~-~~~~ 438 (908) +.|.+.+ .+.. .+... .....+..++..+|||+++++++++++....+.. ..|... ...+ T Consensus 263 ~~~~~~~~~~~~-----------~~~~~-----~~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~--~~~~~~~~~~~ 324 (395) T 3H6G_A 263 EKWSMERLQAPP-----------KPDSG-----LLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSS--LQCNRHKPWRF 324 (395) T ss_dssp HHHHHC-----------------CCSSC-----BCTTCCCHHHHHHHHHHHHHHHHHHTCTTCCCCC--CCTTSCCCCTT T ss_pred HHHHHHhhcCCC-----------CCCCC-----ccCcCCChHHHHHHHHHHHHHHHHHhccccCCCC--CCCCCCCCccc Confidence 2222211 1100 00000 0001134567889999999999999986543211 112111 1123 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) +..+.+.|++..|.|.+| ++.||++|++...+.+..++.. ++.++.||.|.... T Consensus 325 ~~~l~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~~~~~~~--~~~~~~vg~~~~~~ 378 (395) T 3H6G_A 325 GTRFMSLIKEAHWEGLTG-RITFNKTNGLRTDFDLDVISLK--EEGLEKIGTWDPAS 378 (395) T ss_dssp HHHHHHHHHHCEEEETTE-EEECCTTTSEECCCCEEEEEEE--TTEEEEEEEEETTT T ss_pred cHHHHHHHHhccccCCcc-eEEEcCCCCcccceEEEEEEee--ccccEEEEEEeCCC Confidence 456777888888999988 8999987666554444333321 35789999998764 No 61 >3H6G_B Glutamate receptor, ionotropic kainate 2; MEMBRANE PROTEIN GLYCOPROTEIN, Cell junction; HET: NAG, TLA; 2.697A {Rattus norvegicus} Probab=99.57 E-value=1.2e-19 Score=196.12 Aligned_cols=373 Identities=17% Similarity=0.207 Sum_probs=226.1 Template_Neff=12.000 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCS-RDTYALEQSLTFVQ 121 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~-~~~~a~~~~~~~~~ 121 (908) .++++||+++|.++.. .+.....|+++|++++|+++++++++++++...|+.. +...+ .+.+. T Consensus 2 ~~~i~ig~~~~~~g~~------------~~~~~~~~~~~a~~~~n~~~~~~~~~~l~~~~~d~~~~~~~~~----~~~~~ 65 (395) T 3H6G_B 2 THVLRFGGIFEYVESG------------PMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEA----SKKAC 65 (395) T ss_dssp CEEEEEEEEEEESSSC------------SCCHHHHHHHHHHHHHHHCSSSSSSEEEEEEEEEEETTCHHHH----HHHHH T ss_pred CCeEEEEEEeccCCCC------------CCcHHHHHHHHHHHHHhcCcccCCCCEEEEEEEecCcchhHHH----HHHHH Confidence 4679999999998742 3567889999999999998877767888887777654 32211 11111 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +.. .++++++||+.++.....++.++...++|+|++.+..+.+.. .+++++++.++... T Consensus 66 ~~~-------------------~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~~ 124 (395) T 3H6G_B 66 DQL-------------------SLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDN--KDSFYVSLYPDFSS 124 (395) T ss_dssp HHH-------------------HHCCSCEECCSSHHHHHHHHHHHHHTTCCEEECSCCCCCTTC--CCCSEEEEEECHHH T ss_pred HHH-------------------hcCceEEECCCCHHHHHHHHHHHHHhCCCEEEeecCccccCC--CCceeEEcCCCHHH Confidence 111 147889999988877777888888999999998775544332 35788999999888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++++++++++++|+++++++.+ .++....+.+.+.+++. ++++... .+. ....++...+++++. .+++++++. T Consensus 125 ~~~~~~~~~~~~~~~~v~il~~~-~~~~~~~~~~~~~~~~~-~~~v~~~-~~~--~~~~~~~~~~~~l~~-~~~~~iv~~ 198 (395) T 3H6G_B 125 LSRAILDLVQFFKWKTVTVVYDD-STGLIRLQELIKAPSRY-NLRLKIR-QLP--ADTKDAKPLLKEMKR-GKEFHVIFD 198 (395) T ss_dssp HHHHHHHHHHHTTCSEEEEEESS-THHHHHTHHHHTGGGTS-SCEEEEE-ECC--SSGGGCHHHHHHHHH-TTCCEEEEE T ss_pred HHHHHHHHHHHcCCCEEEEEEeC-CccHHHHHHHHHCcCcc-CceEEEE-ECC--CCCCCcHHHHHHHHh-CCCeEEEEE Confidence 88999999888899999999954 37766677777776664 3554432 222 223355666777753 477888877 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ........+++++++.|+.. .+.|+........... . .....+... ..+..+ . ...+....+. T Consensus 199 ~~~~~~~~~l~~~~~~g~~~~~~~~~~~~~~~~~~~~-~--~~~~~~~~~--------~~~~~~-~----~~~~~~~~~~ 262 (395) T 3H6G_B 199 CSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDV-E--PYRYSGVNM--------TGFRIL-N----TENTQVSSII 262 (395) T ss_dssp SCHHHHHHHHHHHHHTTCCSTTCEEEECCTTGGGBCC-T--TTTTSCCEE--------EEEECS-C----TTSHHHHHHH T ss_pred CCHHHHHHHHHHHHHcCCCcCCeEEEEeeCCcccCcc-h--hhccCCeee--------EEEEEe-c----CCCcchHHHH Confidence 76677788899998888753 2345543211100000 0 000001000 000000 0 0001111222 Q NP_000836.2 361 EFWEENF-GCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM-STID 438 (908) Q Consensus 361 ~~~~~~~-~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~-~~~~ 438 (908) +.|.+.+ .+.. .+... .....+..++..+|||+++++++++++....+.. ..|... ...+ T Consensus 263 ~~~~~~~~~~~~-----------~~~~~-----~~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~--~~~~~~~~~~~ 324 (395) T 3H6G_B 263 EKWSMERLQAPP-----------KPDSG-----LLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSS--LQCNRHKPWRF 324 (395) T ss_dssp HHHHHHHTTSCC-----------CSSSC-----BCTTCCCHHHHHHHHHHHHHHHHHHTCTTCCCCC--CCTTSCCCCTT T ss_pred HHHHHHhhcCCC-----------CCCCC-----ccCcCCChHHHHHHHHHHHHHHHHHhccccCCCC--CCCCCCCCccc Confidence 2222211 1100 00000 0001134567889999999999999986543211 112111 1123 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) +..+.+.|++..|.|.+| ++.||++|++...+.+..++.. ++.++.||.|.... T Consensus 325 ~~~l~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~~~~~~~--~~~~~~vg~~~~~~ 378 (395) T 3H6G_B 325 GTRFMSLIKEAHWEGLTG-RITFNKTNGLRTDFDLDVISLK--EEGLEKIGTWDPAS 378 (395) T ss_dssp HHHHHHHHHTCEEEETTE-EEECCTTTSEECCCCEEEEEEE--TTEEEEEEEEETTT T ss_pred cHHHHHHHHhccccCCcc-eEEEcCCCCcccceEEEEEEee--ccccEEEEEEeCCC Confidence 456777888888999988 8999987666554444333321 35789999998764 No 62 >6JFY_B Glutamate receptor ionotropic, kainate 3; Glutamate receptor, Kainate, SYM, MEMBRANE; 7.4A {Rattus norvegicus} Probab=99.57 E-value=1.2e-19 Score=216.12 Aligned_cols=373 Identities=15% Similarity=0.201 Sum_probs=239.8 Template_Neff=11.300 Q NP_000836.2 43 DGDIILGGLFPVHAK-GERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTFV 120 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~-~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~~ 120 (908) +++++||+++|.++. .. ..+.....|+++|++++|+.+++++|+++++++.|++ +++..+ .+.+ T Consensus 2 ~~~i~ig~~~~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~~~~~~g~~l~l~~~d~~~~~~~~~----~~~~ 67 (809) T 6JFY_B 2 PHVIRIGGIFEYADGPNA----------QVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEA----TKKA 67 (809) T ss_pred CCceEEEEEEeCCCCchh----------HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEeCCCCCHHHH----HHHH Confidence 468999999999864 21 3567889999999999999887777889999999977 453332 2233 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. +++++++|+.++..+.+++..++..++|++++.++++.+.+ ..++++++.|++. T Consensus 68 ~~l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~ 126 (809) T 6JFY_B 68 CDQLA-------------------LGVVAIFGPSQGSTTNAVQSICNALEVPHIQLRWKHHPLDN--KDTFYVNLYPDYA 126 (809) T ss_pred HHHHH-------------------cCCCEEEcCCCcHHHHHHHHHHHHHCCCEEeCCCCCcccCC--CCCCeeecCCCHH Confidence 33322 47899999888877778888889999999998876665443 2577999999999 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) .+++++++++++++|+++++++ +++++....+.+++.+++. ++++.... +. .+..++...++++++ .++|+|++ T Consensus 127 ~~~~~~~~~l~~~~~~~v~iv~-~~~~~~~~~~~~~~~~~~~-g~~v~~~~-~~--~~~~~~~~~~~~l~~-~~~~~vv~ 200 (809) T 6JFY_B 127 SLSHAILDLVQSLKWRSATVVY-DDSTGLIRLQELIMAPSRY-NIRLKIRQ-LP--IDSDDSRPLLKEMKR-GREFRIIF 200 (809) T ss_pred HHHHHHHHHHHHhCCCEEEEEE-eChhhHHHHHHHHHHHHHC-CCEEEeee-cC--CCCCCcHHHHHHHHH-hCCCEEEE Confidence 9999999999888999999999 6778888888888888775 46665433 22 223456677777763 57899988 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) .+....+..++++++++|+.. .+.|+..+.+...... ........+...... + . ...+....| T Consensus 201 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~----------~-~----~~~~~~~~f 264 (809) T 6JFY_B 201 DCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDL-EPYRYSGVNLTGFRI----------L-N----VDNPHVSAI 264 (809) T ss_pred eCCHHHHHHHHHHHHHcCCCCCCeeEEEecCCCCCCch-HhhcCCceeEEEEec----------C-C----CCChHHHHH Confidence 877777888999999888754 2456654432211100 000000011110000 0 0 001111122 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM-STID 438 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~-~~~~ 438 (908) .+.+++.+..... ..|... ....++.++..+|||++++++|++++....+.. ..|... ...+ T Consensus 265 ~~~~~~~~~~~~~---------~~~~~~------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~--~~~~~~~~~~~ 327 (809) T 6JFY_B 265 VEKWSMERLQAAP---------RAESGL------LDGVMMTDAALLYDAVHIVSVTYQRAPQMTVNS--LQCHRHKAWRF 327 (809) T ss_pred HHHHHHHHCCCCC---------CCCCCC------CCCCCCHHHHHHHHHHHHHHHHHHHhcCCCCCc--cccccCCCccc Confidence 2222222110000 000000 001234567889999999999999987532111 111111 1124 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDA-P-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~-~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ++.+.++|++..|.|.+| ++.||++|++ . ..+.+.+++ ++.++.+|.|.+. T Consensus 328 ~~~l~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~~i~~~~----~~~~~~v~~~~~~ 380 (809) T 6JFY_B 328 GGRFMNFIKEAQWEGLTG-RIVFNKTSGLRTDFDLDIISLK----EDGLEKVGVWSPA 380 (809) T ss_pred HHHHHHHHHhcCcCCCCC-cEEecCCCCccceeEEEEEecc----CCceEEeEEEeCC Confidence 567788888889999988 8999986443 3 266777776 2568888988764 No 63 >5L2E_B Cerebellin-1; Synapse Protein, Cell Surface Protein; 4.152A {Rattus norvegicus} Probab=99.57 E-value=1.3e-19 Score=211.78 Aligned_cols=379 Identities=16% Similarity=0.219 Sum_probs=233.2 Template_Neff=11.900 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI-LDTCSRDTYALEQSLTFV 120 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~-~d~~~~~~~a~~~~~~~~ 120 (908) .+++++||+++|.++ .....|++.|++++|+++++++|+++++++ .|+++++..+.+.+ T Consensus 2 ~~~~i~Ig~~~~~~~----------------~~~~~~~~~a~~~iN~~~~~~~g~~i~~~~~~d~~~~~~~a~~~~---- 61 (688) T 5L2E_B 2 SDSIIHIGAIFDESA----------------KKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEA---- 61 (688) T ss_dssp -CCCEEEEEEEETTC----------------HHHHHHHHHHHHHHHHCSSSSTTCCEEEEEEEECTTCHHHHHHHH---- T ss_pred CCceeeeEEEecCCC----------------chhHHHHHHHHHHHhcCcccccCcceEEEEEEeCCCCHHHHHHHH---- Confidence 357899999999875 245689999999999988777789999998 88887754433333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAP-------ELSDNTRYDFFS 193 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~-------~l~~~~~~~~~~ 193 (908) .+++. ++++++||+.++..+..++.++...++|+|++.+..+ .+++...+++++ T Consensus 62 ~~l~~-------------------~~v~~viG~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~l~~~~~~~~~~ 122 (688) T 5L2E_B 62 CELMN-------------------QGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYT 122 (688) T ss_dssp HHHHH-------------------HCCSCEEEEECHHHHHHHHHHHHHHTCCEEEEECCGGGCCCCCCCCCCCTTSCCCE T ss_pred HHHHH-------------------cCeeEEEecCCcchHHHHHHHHHHcCCCEEEeecCCCCCCCCCcccccCCCCCceE Confidence 33322 4788999998887777788888999999999876554 333334578899 Q NP_000836.2 194 RVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE------PRPGEFEKIIK 267 (908) Q Consensus 194 ~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~------~~~~~~~~~~~ 267 (908) ++.+++..++.++++++++++|+++++++++ +++....+.+.+.+++. ++++.....++.. ....+....++ T Consensus 123 ~~~~~~~~~~~~l~~~~~~~~~~~v~i~~~~-~~g~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~~~l~ 200 (688) T 5L2E_B 123 LSVRPPVYLNEVILRVVTEYAWQKFIIFYDS-EYDIRGIQEFLDKVSQQ-GMDVALQKVENNINKMITTLFDTMRIEELN 200 (688) T ss_dssp EECSCCCCHHHHHHHHHHHTTCCEEEEEECT-TCCGGGGHHHHHHHHHT-TCEEEEEECCSCHHHHHHHHHHHSCHHHHH T ss_pred EEecCChhHHHHHHHHHHHhCCcEEEEEEcC-ccchHHHHHHHHHHHhc-CcchHHHHhhchhHHhHHhhhccccHHHHH Confidence 9999988889999999988899999988754 47777777888777765 4665443222110 00122334445 Q NP_000836.2 268 RLLETPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFR 346 (908) Q Consensus 268 ~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~ 346 (908) ++. ..+++|++......+..+++++++.|+.. ++.|+..+.+...............+........ . T Consensus 201 ~~~--~~~~~ii~~~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------~ 268 (688) T 5L2E_B 201 RYR--DTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTF----------P 268 (688) T ss_dssp HHH--HHTTEEEEESCHHHHHHHHHHHHHTTSSCTTCEEEEECSCCCHHHHHHHHHHCCSEEEEEEECC----------C T ss_pred HHH--HhccEEEEEcCHHHHHHHHHHHHHccCcCCCeEEEEecCCcccCChHHHHhhccceEEEEEecC----------C Confidence 443 25777777766667788999998888753 4567766543322110000001111111111000 0 Q NP_000836.2 347 SRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG 426 (908) Q Consensus 347 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~ 426 (908) .........+.+.+++.+. .|...... ...+..++..+|||++++++|++++....+.. T Consensus 269 ---~~~~~~~~~~~~~~~~~~~--------------~~~~~~~~----~~~~~~~~~~~ydav~~~~~al~~~~~~~~~~ 327 (688) T 5L2E_B 269 ---VPQNISQRCFRGNHRISST--------------LCDPKDPF----AQNMEISNLYIYDTVLLLANAFHKKLQDRKWH 327 (688) T ss_dssp ---CCCSSGGGSEETTEECCHH--------------HHCTTSHH----HHTCCHHHHHHHHHHHHHHHHHHHHHHTTCCC T ss_pred ---CCchhhhhccccCcccCCC--------------cCCCCCCc----cccccchHHHHHHHHHHHHHHHHHHHHcCCCC Confidence 0000111112222222111 11000000 01234567789999999999999986543210 Q NP_000836.2 427 --YIGLCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDA-PGRYDIFQYQITN-KSTEYKVIGHWTNQL 495 (908) Q Consensus 427 --~~~~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~-~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~ 495 (908) ....|... ...++..+.++|++.+|.|.+| .+.|+++|++ ...+.+++++... +...++.||.|.... T Consensus 328 ~~~~~~c~~~~~~~~~~~~~l~~~l~~~~~~g~~G-~v~f~~~g~~~~~~~~i~~~~~~~~~~~~~~~vg~~~~~~ 402 (688) T 5L2E_B 328 SMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTG-DLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVT 402 (688) T ss_dssp CCCCCCSSSTTCCCCTTHHHHHHHHHTCEEECSSS-EEECCTTSBCCCCCEEEEEC--------CCEEEEEEETTT T ss_pred CCCCcccccCCCCCCccchHHHHHHHhCccccccc-eEEecCCCccceeEEEEEecCCCcccCCcEEEEEEEeCCC Confidence 01122111 0114556778888889999988 8999999985 4678888887421 235789999998764 No 64 >3QEK_B NMDA glutamate receptor subunit; amino terminal domain, ion channel; HET: MSE, NAG, BMA; 2.001A {Xenopus laevis} Probab=99.57 E-value=1.3e-19 Score=195.07 Aligned_cols=349 Identities=18% Similarity=0.255 Sum_probs=220.0 Template_Neff=11.900 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.+ ....|+++|++++|+.+ .++++++++...|+..++..+ .+.+.+ T Consensus 3 ~~~i~Ig~~~~~~------------------~~~~~~~~a~~~~n~~~-~~~~~~l~~~~~~~~~~~~~~----~~~~~~ 59 (384) T 3QEK_B 3 PKIVNIGAVLSTK------------------KHEQIFREAVNQANKRH-FTRKIQLQATSVTHRPNAIQM----ALSVCE 59 (384) T ss_dssp CCEEEEEEEESSH------------------HHHHHHHHHHHHHHHHC-----CEEEEEEEECCSSHHHH----HHHCCC T ss_pred CcceEEEEEechH------------------HHHHHHHHHHHHHhHhh-cCCCeeEEEEEecCCcCHHHH----HHHHHH Confidence 4689999999875 24578999999999864 345777777665544443222 222222 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAA-----ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-----~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) ++. .+++++++|+. ++..+..++.++...++|+|++.+..+.+.+...+++++++.| T Consensus 60 ~~~------------------~~~v~~vig~~~~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~ 121 (384) T 3QEK_B 60 DLI------------------SSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVP 121 (384) T ss_dssp CCG------------------GGTEEEEEECCC-------CCHHHHHHHHTTTCCEEESSCCCGGGGCSSSCTTEEESSC T ss_pred HHH------------------hcCcEEEEECCCCCCCCcCChHHHHHHHHhhCCCEEEccCCCccccCccccceEeecCC Confidence 221 15788999953 3344456677888899999998877666554335688999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQS-------QKIP------------REPR 258 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~-------~~~~------------~~~~ 258 (908) +....+.++++++.+++|+++++++.++.++....+.+++.+++. ++++... ..+. .... T Consensus 122 ~~~~~~~~~~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 200 (384) T 3QEK_B 122 PYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEGK-ESKSKKRNYENLDQLSYDNKRGPKADKVLQFEPG 200 (384) T ss_dssp CGGGGHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHH-HHHHHHHTC-------------CEEEEEEEECTT T ss_pred CHHHHHHHHHHHHHHcCCcEEEEEEecCcchhHHHHHHHHHHhcC-CCccccccccccccccccCCCCCCccceeecCCC Confidence 998889999999988899999999987778887778888777765 3442110 0000 0011 Q NP_000836.2 259 PGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRAS 337 (908) Q Consensus 259 ~~~~~~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~ 337 (908) ..++...+++++. .++|+|++.........+++++++.|+.+ ++.|+..+.+..... ......+. T Consensus 201 ~~~~~~~~~~i~~-~~~~~ii~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~~~~~~~~----~~~~~~~~--------- 266 (384) T 3QEK_B 201 TKNLTALLLEAKE-LEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSA----LRYAPDGI--------- 266 (384) T ss_dssp CCCCHHHHHHHHT-SSCCEEEEECCHHHHHHHHHHHHHTTCSSTTCEEEECSGGGSHHH----HHHCCTTC--------- T ss_pred chhHHHHHHHHHh-CCCeEEEEECCHHHHHHHHHHHHHcCCCCCCEEEEEeccccCCch----hhcCCCcE--------- Confidence 2345566777763 57899888877777788889888887753 456665543221100 00000000 Q NP_000836.2 338 IDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALH 417 (908) Q Consensus 338 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~ 417 (908) +... ...+..++..+|||+++++++++ T Consensus 267 -----------------------------~~~~------------------------~~~~~~~~~~~ydav~~~~~al~ 293 (384) T 3QEK_B 267 -----------------------------IGLQ------------------------LINGKNESAHISDAVAVVAQAIH 293 (384) T ss_dssp -----------------------------EEEE------------------------ETTTTCHHHHHHHHHHHHHHHHH T ss_pred -----------------------------EEEE------------------------ecCCCcchhHHHHHHHHHHHHHH Confidence 0000 00112356789999999999999 Q NP_000836.2 418 NMHKDLCPG-YIGLCPRM--STIDGKELLGYIRA-VNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 418 ~~~~~~~~~-~~~~~~~~--~~~~~~~l~~~l~~-~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) ++....+.. ....|... ....+..+.+.|++ ..|.|.+| ++.||++|++. ..+.+++++ ++.++.+|.|+ T Consensus 294 ~~~~~~~~~~~~~~c~~~~~~~~~~~~l~~~l~~~~~~~g~~G-~i~fd~~g~~~~~~~~i~~~~----~~~~~~vg~~~ 368 (384) T 3QEK_B 294 ELFEMENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTG-RIEFNEDGDRKFAQYSIMNLQ----NRKLVQVGIFN 368 (384) T ss_dssp HHTTSSCCCCCCSCCTTCCCCCTTHHHHHHHHHTCCEEEETTE-EECBCTTSCBCSCCEEEEEEE----TTEEEEEEEEC T ss_pred HHHhcCCCCCCCCCcCCCcchhccHHHHHHHHhcCCCCCCCCC-CEEECCCCCcCceEEEEEEcc----CCeEEEEEEEe Confidence 986532110 01122111 11234556677765 56889888 89999999986 688888887 35799999998 Q NP_000836.2 493 NQL-HLKVEDMQWA 505 (908) Q Consensus 493 ~~~-~~~~~~i~w~ 505 (908) ... .++...+.|+ T Consensus 369 ~~~~~~~~~~~~w~ 382 (384) T 3QEK_B 369 GSYIIQNDRKIIWP 382 (384) T ss_dssp SSSEEECSSCCCCT T ss_pred CCccccCCCcccCC Confidence 652 2233457774 No 65 >6LU9_D Glutamate receptor ionotropic, delta-2; Membrane protein;{Rattus norvegicus} Probab=99.57 E-value=1.3e-19 Score=217.96 Aligned_cols=374 Identities=16% Similarity=0.230 Sum_probs=233.0 Template_Neff=11.400 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI-LDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~-~d~~~~~~~a~~~~~~~~~~ 122 (908) ++++||+++|.++ .....|+++|++++|+++++++|+++++.+ .|+++++..+.+. +.+ T Consensus 2 ~~i~IG~~~p~~g----------------~~~~~~~~~Ai~~in~~~~~~~g~~i~~~~~~d~~~~~~~~~~~----~~~ 61 (877) T 6LU9_D 2 SIIHIGAIFDESA----------------KKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQE----ACE 61 (877) T ss_dssp CSSEEEEEECTTT----------------HHHHHHHHHHHHHHHTCCSSCSSCCCEEEEEECCTTCHHHHHHH----HHH T ss_pred CeEEEEEEeccCc----------------cchHHHHHHHHHHHHccccccccccceeEEEEcCCCCHHHHHHH----HHH Confidence 5789999999864 246789999999999988777789999988 8887765443333 333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAP-------ELSDNTRYDFFSRV 195 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~-------~l~~~~~~~~~~~~ 195 (908) ++. +++++++|+.++..+..++..+...++|++++.++.+ .+++...++++++. T Consensus 62 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~l~~~~~~~~~~~~ 122 (877) T 6LU9_D 62 LMN-------------------QGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLS 122 (877) T ss_dssp HHH-------------------HCCSCEEEEECHHHHHHHHHHHHHHTCCEEEEECCGGGCCCCCCSCCSCTTSCCCEEE T ss_pred HHH-------------------cCeeEEEecCChhhHHHHHHHHHHcCCCEEEeecCCCCCCCCCCCcccCCCCCCeEEE Confidence 332 5789999998887777888889999999999877655 34333456788888 Q NP_000836.2 196 VPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEF--------EKIIK 267 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~--------~~~~~ 267 (908) .+++..+++++++++++++|+++++++ +++++....+.+.+.+++. ++++.....++. +..++ ...++ T Consensus 123 ~~~~~~~~~~l~~~l~~~~~~~v~il~-~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~--~~~~~~~~~~~~~~~~l~ 198 (877) T 6LU9_D 123 VRPPVYLNEVILRVVTEYAWQKFIIFY-DSEYDIRGIQEFLDKVSQQ-GMDVALQKVENN--INKMITTLFDTMRIEELN 198 (877) T ss_dssp CSCCCCHHHHHHHHHHHTTCSEEEEEE-CTTSCGGGSHHHHHHHHHT-TCEEEEEECCSS--HHHHHHHHHHHSCHHHHH T ss_pred ecCChhHHHHHHHHHHHhCCcEEEEEE-cCcccHHHHHHHHHHHHhc-CCceeEeecccc--hhHhHHHHHhhhcHHHHH Confidence 888777888999998888999999999 7778877778888877765 355543322221 11111 12233 Q NP_000836.2 268 RLLETPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFR 346 (908) Q Consensus 268 ~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~ 346 (908) ++. .++|+|++......+..+++++++.|+.. .+.|+..+.+...............+........ . T Consensus 199 ~~~--~~~~~ii~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------~ 266 (877) T 6LU9_D 199 RYR--DTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTF----------P 266 (877) T ss_dssp HHH--HHTTEEEEESCHHHHHHHHHHHHHTTSSCSSCEEEEECSCCCHHHHHHHHHHCSSEEEEEEEEC----------C T ss_pred HhH--HhCCeEEEEcCHHHHHHHHHHHHHcCCccCceEEEEEeCCcccccHHHHhhhhcccEEEEEecc----------C Confidence 332 36788887777777888999999888753 4567766543321110000000111111110000 0 Q NP_000836.2 347 SRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG 426 (908) Q Consensus 347 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~ 426 (908) .........+.+.+++.+. .|...+.. ...+..++..+|||++++++|++++....+.. T Consensus 267 ---~~~~~~~~~f~~~~~~~~~--------------~~~~~~~~----~~~~~~~~~~~ydav~~~~~al~~~~~~~~~~ 325 (877) T 6LU9_D 267 ---VPQNISQRCFRGNHRISST--------------LCDPKDPF----AQNMEISNLYIYDTVLLLANAFHKKLQDRKWH 325 (877) T ss_dssp ---CCSSHHHHHEETTEECCTT--------------TSCTTSHH----HHTCCHHHHHHHHHHHHHHHHHHHHHHTTCCC T ss_pred ---CCcccccccccccccccCC--------------cCCCCCCc----ccccchhHHHHHHHHHHHHHHHHHHHHcCCcc Confidence 0000011112222221111 01000000 01234567889999999999999886532110 Q NP_000836.2 427 --YIGLCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDA-PGRYDIFQYQITN-KSTEYKVIGHWTNQ 494 (908) Q Consensus 427 --~~~~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~-~~~~~i~~~~~~~-~~~~~~~Vg~~~~~ 494 (908) ....|... ...++..+.+++++..|.|.+| .+.||++|++ ...+.+++++..+ ..+.+..||.|... T Consensus 326 ~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~~~~~~~~~~~~v~~~~~~ 399 (877) T 6LU9_D 326 SMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTG-DLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPV 399 (877) T ss_dssp CCCCCCSSSTTCCCCHHHHHHHHHHHTCEEECSSS-EEECCTTSBCCCCEEEEEEEEEEETTEEEEEEEEEEETT T ss_pred ccccccccCCCCCccccchHHHHHHHhcccCceee-eEEcCCCCCcccEEEEEEecccccccCCcEEEEEEEeCC Confidence 00112110 1124566888888889999998 8999999998 4688888887421 12468888988754 No 66 >1USG_A LEUCINE-SPECIFIC BINDING PROTEIN; LEUCINE-BINDING PROTEIN, PROTEIN STRUCTURE, ABC; 1.53A {ESCHERICHIA COLI} SCOP: c.93.1.1 Probab=99.56 E-value=2.1e-19 Score=190.09 Aligned_cols=335 Identities=20% Similarity=0.239 Sum_probs=214.3 Template_Neff=12.300 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ++++||+++|.++... ..+.....+++.|++++|+.+++. |+++++.+.|+.+++.. ..+.++++ T Consensus 1 ~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~~~~~~~-g~~i~~~~~~~~~~~~~----~~~~~~~l 65 (346) T 1USG_A 1 DDIKVAVVGAMSGPIA----------QWGDMEFNGARQAIKDINAKGGIK-GDKLVGVEYDDACDPKQ----AVAVANKI 65 (346) T ss_dssp CCEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHHHHTTTBT-TBCEEEEEEECTTCHHH----HHHHHHHH T ss_pred CCeEEEEEecCCCCch----------hhhHHHHHHHHHHHHHHHHCCCCC-CceEEEEEEcCCCCHHH----HHHHHHHH Confidence 3689999999775321 255678899999999999876543 67788888776655332 23334433 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) +. ++++++|++.++.....+...+...++|+|.+....+.+... .+++++++.+++...+ T Consensus 66 ~~-------------------~~v~~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~~-~~~~~~~~~~~~~~~~ 125 (346) T 1USG_A 66 VN-------------------DGIKYVIGHLCSSSTQPASDIYEDEGILMISPGATNPELTQR-GYQHIMRTAGLDSSQG 125 (346) T ss_dssp HH-------------------TTCCEEECCSSHHHHHHHHHHHHHHTCEEEECCCCCGGGGSS-CCSSEEECSCCGGGHH T ss_pred Hh-------------------CCCCEEEcCCCchhhHHHHHHHHHhCCEEEecCCCCHHHHhc-CCCceEEecCChhhhH Confidence 32 478889988776665566677788899999987665544322 3567888888888888 Q NP_000836.2 204 QAMVDIV-TALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 204 ~~~~~~l-~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) +.+++++ ++.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++|++++.. T Consensus 126 ~~~~~~l~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i~~~~ 201 (346) T 1USG_A 126 PTAAKYILETVKPQRIAIIHDKQQYGEGLARSVQDGLKAA-NANVVFFDGIT--AGEKDFSALIARLKK-ENIDFVYYGG 201 (346) T ss_dssp HHHHHHCCCCCCCSSEEEEECSSHHHHHHHHHHHHHHHHT-TCCEEEEEECC--TTCCCCHHHHHHHHH-TTCCEEEEES T ss_pred HHHHHHHHHhhCCCEEEEEEcCCccchhHHHHHHHHHHHC-CCeEeEEeccC--CCCCChHHHHHHHHH-CCCCEEEEec Confidence 8889887 45689999999976667778888888888775 35554322222 122345556666653 5788888776 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEF 362 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 362 (908) .+..+..+++++++.|+ ++.|++.+.+...... ........+.+...+.. +...+....|.+. T Consensus 202 ~~~~~~~~~~~~~~~g~--~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~--------------~~~~~~~~~f~~~ 264 (346) T 1USG_A 202 YYPEMGQMLRQARSVGL--KTQFMGPEGVGNASLS-NIAGDAAEGMLVTMPKR--------------YDQDPANQGIVDA 264 (346) T ss_dssp CHHHHHHHHHHHHHTTC--CCEEEECGGGCCTTHH-HHHGGGGTTCEEEECCC--------------GGGSGGGHHHHHH T ss_pred ChHHHHHHHHHHHHcCC--CCeEEcCcccccHHHH-HHHchhhcCcEEEcCCC--------------cCCChhHHHHHHH Confidence 55567788888888877 3567766543322110 00011122222111100 0001111222222 Q NP_000836.2 363 WEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKEL 442 (908) Q Consensus 363 ~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~l 442 (908) +++.+. ..+..++..+|||++++++++++.... +++.+ T Consensus 265 ~~~~~~---------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~---------------~~~~i 302 (346) T 1USG_A 265 LKADKK---------------------------DPSGPYVWITYAAVQSLATALERTGSD---------------EPLAL 302 (346) T ss_dssp HHHTTC---------------------------CCCCHHHHHHHHHHHHHHHHHHHHCCC---------------CHHHH T ss_pred HHHhhC---------------------------CCCCHHHHHHHHHHHHHHHHHHHhCCC---------------CHHHH Confidence 222111 112345778999999999999886531 34467 Q NP_000836.2 443 LGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQ 477 (908) Q Consensus 443 ~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~ 477 (908) .+.|++..|.|.+| ++.||++|++. ..+.+++++ T Consensus 303 ~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~ 337 (346) T 1USG_A 303 VKDLKANGANTVIG-PLNWDEKGDLKGFDFGVFQWH 337 (346) T ss_dssp HHHHHHHCEEETTE-EECBCTTSSBSSCCCEEEEEC T ss_pred HHHHHhCCCCccCc-ceeeCCCCCcCcccEEEEEEe Confidence 78888888999999 89999988876 467777776 No 67 >3IP6_A ABC transporter, substrate binding protein; VENUS FLYTRAP DOMAIN, TRANSPORT PROTEIN; 1.4A {Agrobacterium tumefaciens} Probab=99.55 E-value=2.6e-19 Score=190.40 Aligned_cols=349 Identities=15% Similarity=0.188 Sum_probs=218.3 Template_Neff=12.000 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ++++||+++|.++.. ...+.....+++.|++++|+.+++. |+++++.+.|+..++. ...+.++++ T Consensus 1 ~~~~Ig~i~~~~~~~----------~~~~~~~~~g~~~a~~~~n~~~~~~-g~~i~~~~~~~~~~~~----~~~~~~~~l 65 (356) T 3IP6_A 1 MDVVIAVGAPLTGPN----------AAFGAQIQKGAEQAAKDINAAGGIN-GEQIKIVLGDDVSDPK----QGISVANKF 65 (356) T ss_dssp CCEEEEEEECSSSTT----------HHHHHHHHHHHHHHHHHHHHTTCBT-TBCEEEEEEECTTCHH----HHHHHHHHH T ss_pred CcEEEEEEecCCCCC----------hHHHHHHHHHHHHHHHHHHHcCCcC-CceeEEEEecCCCCHH----HHHHHHHHH Confidence 368999999976532 1256678899999999999876543 6778887777655433 223334443 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) +. ++++++|++.++.....+...+...++|+|.+....+.+... ..++++++.++....+ T Consensus 66 ~~-------------------~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~~~~~ 125 (356) T 3IP6_A 66 VA-------------------DGVKFVVGHFNSGVSIPASEVYAENGILEITPAATNPVFTER-GLWNTFRTCGRDDQQG 125 (356) T ss_dssp HH-------------------TTCCEEEECSSHHHHHHHHHHHHTTTCEEEESSCCCGGGGSS-CCTTEEESSCCHHHHH T ss_pred HH-------------------CCCCEEEecCCchhhHHHHHHHHHcCCEEEccCCCChhhhcc-CCcCeEEecCChhHHH Confidence 32 478889987766655566677788899999988765543322 2356788888888888 Q NP_000836.2 204 QAMVDIV-TALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 204 ~~~~~~l-~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) +.+++++ ++++|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....++++++ .+++++++.. T Consensus 126 ~~~~~~l~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i~~~~ 201 (356) T 3IP6_A 126 GIAGKYLADHFKDAKVAIIHDKTPYGQGLADETKKAANAA-GVTEVMYEGVN--VGDKDFSALISKMKE-AGVSIIYWGG 201 (356) T ss_dssp HHHHHHHHHHCTTCCEEEEECSSHHHHHHHHHHHHHHHHT-TCCCSEEEECC--TTCCCCHHHHHHHHH-TTCCEEEEES T ss_pred HHHHHHHHHhcCCCeEEEEeCCChhhHHHHHHHHHHHHHC-CCeeeEeeccC--CCCCChHHHHHHHHH-hCCCEEEEeC Confidence 8888888 45699999999976667777888888888775 35543322222 122344555666653 4778877776 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEF 362 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 362 (908) .+..+..+++++++.|+. ..|++.+.+...... ........+.+..... . +...+....|.+. T Consensus 202 ~~~~~~~~~~~~~~~g~~--~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~---~~~~~~~~~f~~~ 264 (356) T 3IP6_A 202 LHTEAGLIIRQAADQGLK--AKLVSGDGIVSNELA-SIAGDAVEGTLNTFGP-----------D---PTLRPENKELVEK 264 (356) T ss_dssp CHHHHHHHHHHHHHHTCC--CEEEECTTCCSHHHH-HHHGGGGTTCEEEECC-----------C---GGGCGGGHHHHHH T ss_pred chHHHHHHHHHHHHCCCC--CeEEEcccccCHHHH-HHHhHHhcCceeecCC-----------C---cccChhHHHHHHH Confidence 566778888988888774 356665543221110 0001112222211100 0 0001111222222 Q NP_000836.2 363 WEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKEL 442 (908) Q Consensus 363 ~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~l 442 (908) +++ +. ..+..++..+|||++++++++++... .++..+ T Consensus 265 ~~~-~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~---------------~~~~~l 301 (356) T 3IP6_A 265 FKA-AG---------------------------FNPEAYTLYSYAAMQAIAGAAKAAGS---------------VEPEKV 301 (356) T ss_dssp HHH-TT---------------------------CCCCTTHHHHHHHHHHHHHHHHHHTC---------------CCHHHH T ss_pred HHH-hC---------------------------CCCChHHHHHHHHHHHHHHHHHHcCC---------------CCHHHH Confidence 221 10 11234567899999999999987642 134567 Q NP_000836.2 443 LGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 443 ~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) .+.|++..|.|.+| .+.||++|++. ..+.+.+++... ++.|+.++.|.. T Consensus 302 ~~~l~~~~~~g~~g-~i~f~~~g~~~~~~~~i~~~~~~~-~g~~~~~~~~~~ 351 (356) T 3IP6_A 302 AEALKKGSFPTALG-EISFDEKGDPKLPGYVMYEWKKGP-DGKFTYIQQGSH 351 (356) T ss_dssp HHHHTTCCBCCTTS-SBCBCTTSCBCCCCCEEEEEEECT-TSSEEEEEC--- T ss_pred HHHHHcCCCCcCce-eEEECCCCCccCCeEEEEEEEeCC-CCcEEEEecCCC Confidence 78888888999888 89999989875 467787876321 357888887753 No 68 >3IPC_A ABC transporter, substrate binding protein; VENUS FLYTRAP DOMAIN, TRANSPORT PROTEIN; 1.3A {Agrobacterium tumefaciens} Probab=99.55 E-value=2.7e-19 Score=190.15 Aligned_cols=348 Identities=16% Similarity=0.198 Sum_probs=218.0 Template_Neff=12.100 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||+++|.++.. ...+.....+++.|++++|+.+++. |+++++.+.|+..++. ...+.+++++ T Consensus 2 ~~~Ig~~~~~~~~~----------~~~~~~~~~~~~~a~~~~n~~~~~~-g~~i~~~~~~~~~~~~----~~~~~~~~l~ 66 (356) T 3IPC_A 2 DVVIAVGAPLTGPN----------AAFGAQIQKGAEQAAKDINAAGGIN-GEQIKIVLGDDVSDPK----QGISVANKFV 66 (356) T ss_dssp CEEEEEEECCSSTT----------HHHHHHHHHHHHHHHHHHHHTTCBT-TBCEEEEEEECTTCHH----HHHHHHHHHH T ss_pred CeEEEEEeCCCCCc----------hHHHHHHHHHHHHHHHHHHHCCCcC-CceeEEEEecCCCCHH----HHHHHHHHHH Confidence 67899999977532 1356778899999999999876543 6778887777655533 2233344333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . ++++++|++.++.....+...+...++|+|.+.+..+.+... ..++++++.++....++ T Consensus 67 ~-------------------~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~ 126 (356) T 3IPC_A 67 A-------------------DGVKFVVGHANSGVSIPASEVYAENGILEITPAATNPVFTER-GLWNTFRTCGRDDQQGG 126 (356) T ss_dssp H-------------------TTCCEEEECSSHHHHHHHHHHHHTTTCEEEESSCCCGGGGSS-CCTTEEESSCCHHHHHH T ss_pred h-------------------CCCCEEEccCCchhhHHHHHHHHHcCCEEEecCCCChhhhcc-CCCCeEEecCChhHHHH Confidence 2 478899988766655566677788899999987655543321 24567888888888888 Q NP_000836.2 205 AMVDIV-TALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFAN 283 (908) Q Consensus 205 ~~~~~l-~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~~ 283 (908) .+++++ ++++|++|++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .+++++++... T Consensus 127 ~~~~~l~~~~~~~~v~~l~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~~~~ 202 (356) T 3IPC_A 127 IAGKYLADHFKDAKVAIIHDKTPYGQGLADETKKAANAA-GVTEVMYEGVN--VGDKDFSALISKMKE-AGVSIIYWGGL 202 (356) T ss_dssp HHHHHHHHHCTTCCEEEEECSSHHHHHHHHHHHHHHHHT-TCCCSEEEECC--TTCCCCHHHHHHHHH-TTCCEEEEESC T ss_pred HHHHHHHHhcCCCEEEEEECCChhhHhHHHHHHHHHHHC-CCeEeEEEccC--CCCcCHHHHHHHHHH-cCCCEEEEeCc Confidence 888887 45699999999966667777888888887765 35544322222 122344556666653 47888777765 Q NP_000836.2 284 EDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFW 363 (908) Q Consensus 284 ~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 363 (908) +..+..+++++++.|+. ..|++.+.+...... ........+.+..... . +...+....|.+.+ T Consensus 203 ~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~---~~~~~~~~~f~~~~ 265 (356) T 3IPC_A 203 HTEAGLIIRQAADQGLK--AKLVSGDGIVSNELA-SIAGDAVEGTLNTFGP-----------D---PTLRPENKELVEKF 265 (356) T ss_dssp HHHHHHHHHHHHHHTCC--CEEEECGGGCSHHHH-HHHGGGGTTCEEEESC-----------C---GGGCGGGHHHHHHH T ss_pred hHHHHHHHHHHHHCCCC--CeEEechhhcCHHHH-HHhhHHhcCceeecCC-----------C---CCCChhHHHHHHHH Confidence 66677889998888874 356665533221110 0001112222211100 0 00001111122222 Q NP_000836.2 364 EENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELL 443 (908) Q Consensus 364 ~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~l~ 443 (908) ++. . ..+..++..+|||++++++++++... .++..+. T Consensus 266 ~~~-~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~---------------~~~~~l~ 302 (356) T 3IPC_A 266 KAA-G---------------------------FNPEAYTLYSYAAMQAIAGAAKAAGS---------------VEPEKVA 302 (356) T ss_dssp HHT-T---------------------------CCCCTTHHHHHHHHHHHHHHHHHHTC---------------CCHHHHH T ss_pred HHc-C---------------------------CCCchHHHHHHHHHHHHHHHHHHcCC---------------CCHHHHH Confidence 110 0 01234567899999999999987642 1345677 Q NP_000836.2 444 GYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 444 ~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) ++|++..|.|.+| ++.||++|++. ..+.+.+++..+ ++.++.++.|+. T Consensus 303 ~~l~~~~~~g~~G-~i~f~~~g~~~~~~~~i~~~~~~~-~g~~~~~~~~~~ 351 (356) T 3IPC_A 303 EALKKGSFPTALG-EISFDEKGDPKLPGYVMYEWKKGP-DGKFTYIQQGSH 351 (356) T ss_dssp HHHTTCCBCCTTS-SBCBCTTSCBCCCCCEEEEEEECT-TSSEEEEEC--- T ss_pred HHHHcCCCCccce-EEEECCCCCccCCeEEEEEEEECC-CccEEEEecCCC Confidence 8888888999888 89999989875 467787886321 357888887764 No 69 >4EYG_B Twin-arginine translocation pathway signal; PSI-BIOLOGY, MCSG, MIDWEST CENTER FOR; HET: VNL, MSE; 1.86A {Rhodopseudomonas palustris} Probab=99.55 E-value=3.1e-19 Score=190.67 Aligned_cols=356 Identities=16% Similarity=0.187 Sum_probs=222.9 Template_Neff=12.100 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|.++... ..+.....+++.|++++|.. ..|+++++.+.|+.+++. ...+.++ T Consensus 3 ~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~~~---~~g~~v~~~~~d~~~~~~----~~~~~~~ 65 (368) T 4EYG_B 3 AEDTFKVGLIVPMTGGQA----------STGKQIDNAIKLYIKKHGDT---VAGKKIEVILKDDAAIPD----NTKRLAQ 65 (368) T ss_dssp -CCEEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHHCSE---ETTEEEEEEEEECTTCHH----HHHHHHH T ss_pred CCCcEEEEEEEcCCCCCh----------HHHHHHHHHHHHHHHHhCCc---cCCEEEEEEEEcCCCCch----HHHHHHH Confidence 457899999999876421 25567888999999998851 235677877777655533 2233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++++++|++..+.....+...+...++|+|.+....+.+.. .+++++++.+++.. T Consensus 66 ~l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~~ 125 (368) T 4EYG_B 66 ELIV------------------NDKVNVIAGFGITPAALAAAPLATQAKVPEIVMAAGTSIITE--RSPYIVRTSFTLAQ 125 (368) T ss_dssp HHHH------------------TSCCSEEEECSSHHHHHHHHHHHHHHTCCEEESSCCCGGGGG--GCTTEEESSCCHHH T ss_pred HHHh------------------cCCcCEEEecCChHHHHHHHHHHHHcCCCEEEcCCCCccccC--CCCcEEEcCCChhh Confidence 4332 157889998876666566667778899999988765543322 24678888898888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++|++++. T Consensus 126 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i~~~ 201 (368) T 4EYG_B 126 SSIIIGDWAAKNGIKKVATLTSDYAPGNDALAFFKERFTAG-GGEIVEEIKVP--LANPDFAPFLQRMKD-AKPDAMFVF 201 (368) T ss_dssp HHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--SSSCCCHHHHHHHHH-HCCSEEEEE T ss_pred hHHHHHHHHHHCCCCEEEEEecCChhhHHHHHHHHHHHHhC-CCeeceEEecC--CCCCCcHHHHHHHHH-hCCCEEEEE Confidence 88899999877899999999966667777888888888765 35543322222 122344556666653 578888877 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) .....+..+++++++.|+.. ++.|++.+.+...... ........+.+...... . ....+....|. T Consensus 202 ~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~---~~~~~~~~~f~ 267 (368) T 4EYG_B 202 VPAGQGGNFMKQFAERGLDKSGIKVIGPGDVMDDDLL-NSMGDAALGVVTAHMYS----------A---AHPSAMNKEFV 267 (368) T ss_dssp CCTTCHHHHHHHHHHTTGGGTTCEEEEEGGGGCTTTG-GGCCGGGTTCEEEESCC----------T---TCCCHHHHHHH T ss_pred eccchHHHHHHHHHHcCCCcCCCEEEccccccCHHHH-HHchhhhCCcEEEeccc----------C---CCCCHHHHHHH Confidence 65466778888888888753 3566665533221110 00111122222211100 0 00001111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++ ..+..++..+|||++++++++++.... .+++ T Consensus 268 ~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~--------------~~~~ 306 (368) T 4EYG_B 268 AAYKKEFG---------------------------QRPGFMAVGGYDGIHLVFEALKKTGGK--------------ADGD 306 (368) T ss_dssp HHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHTTTC--------------CSHH T ss_pred HHHHHHHC---------------------------CCCChHHHHHHHHHHHHHHHHHHhCCC--------------CCHH Confidence 22222111 112345778999999999999886421 2345 Q NP_000836.2 441 ELLGYIRAVNFNGSAGTPVTFNEN-GDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 441 ~l~~~l~~~~f~G~~G~~v~Fd~~-G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .+.++|++.+|.|.+| ++.|+++ |++...+.+.+++..++...++.+|.|... T Consensus 307 ~v~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~i~~~~~~~g~~~~~~vg~~~~~ 360 (368) T 4EYG_B 307 SLIAAMKGMKWESPRG-PISIDPETRDIVQNIYIRKVEKVDGELYNIEFAKFDAV 360 (368) T ss_dssp HHHHHHTTCEEEETTE-EEEECTTTCCEEEEEEEEEEEEETTEEEEEEEEEEEEE T ss_pred HHHHHHhCCCccCCCc-ceEeCCCCCcccceEEEEEEEeeCCeEEEeEEEEecCC Confidence 6778888778999888 8999975 566667888888732223457888888754 No 70 >4EYK_A Twin-arginine translocation pathway signal; PSI-BIOLOGY, MCSG, MIDWEST CENTER FOR; HET: DHB; 1.9A {Rhodopseudomonas palustris} Probab=99.55 E-value=3.1e-19 Score=190.67 Aligned_cols=356 Identities=16% Similarity=0.187 Sum_probs=222.9 Template_Neff=12.100 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|.++... ..+.....+++.|++++|.. ..|+++++.+.|+.+++. ...+.++ T Consensus 3 ~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~~~---~~g~~v~~~~~d~~~~~~----~~~~~~~ 65 (368) T 4EYK_A 3 AEDTFKVGLIVPMTGGQA----------STGKQIDNAIKLYIKKHGDT---VAGKKIEVILKDDAAIPD----NTKRLAQ 65 (368) T ss_dssp -CCEEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHHCSE---ETTEEEEEEEEECTTCHH----HHHHHHH T ss_pred CCCcEEEEEEEcCCCCCh----------HHHHHHHHHHHHHHHHhCCc---cCCEEEEEEEEcCCCCch----HHHHHHH Confidence 457899999999876421 25567888999999998851 235677877777655533 2233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++++++|++..+.....+...+...++|+|.+....+.+.. .+++++++.+++.. T Consensus 66 ~l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~~ 125 (368) T 4EYK_A 66 ELIV------------------NDKVNVIAGFGITPAALAAAPLATQAKVPEIVMAAGTSIITE--RSPYIVRTSFTLAQ 125 (368) T ss_dssp CCCC------------------CSCCSEEEECCSHHHHHHHHHHHHHHTCCEEESSCCCGGGGG--GCTTEEESSCCHHH T ss_pred HHHh------------------cCCcCEEEecCChHHHHHHHHHHHHcCCCEEEcCCCCccccC--CCCcEEEcCCChhh Confidence 4332 157889998876666566667778899999988765543322 24678888898888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++|++++. T Consensus 126 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i~~~ 201 (368) T 4EYK_A 126 SSIIIGDWAAKNGIKKVATLTSDYAPGNDALAFFKERFTAG-GGEIVEEIKVP--LANPDFAPFLQRMKD-AKPDAMFVF 201 (368) T ss_dssp HHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--SSSCCCHHHHHHHHH-HCCSEEEEE T ss_pred hHHHHHHHHHHCCCCEEEEEecCChhhHHHHHHHHHHHHhC-CCeeceEEecC--CCCCCcHHHHHHHHH-hCCCEEEEE Confidence 88899999877899999999966667777888888888765 35543322222 122344556666653 578888877 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) .....+..+++++++.|+.. ++.|++.+.+...... ........+.+...... . ....+....|. T Consensus 202 ~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~---~~~~~~~~~f~ 267 (368) T 4EYK_A 202 VPAGQGGNFMKQFAERGLDKSGIKVIGPGDVMDDDLL-NSMGDAALGVVTAHMYS----------A---AHPSAMNKEFV 267 (368) T ss_dssp CCTTCHHHHHHHHHHTTGGGTTCEEEEEGGGGCHHHH-TTCCGGGTTCEEEESCC----------T---TCCCHHHHHHH T ss_pred eccchHHHHHHHHHHcCCCcCCCEEEccccccCHHHH-HHchhhhCCcEEEeccc----------C---CCCCHHHHHHH Confidence 65466778888888888753 3566665533221110 00111122222211100 0 00001111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++ ..+..++..+|||++++++++++.... .+++ T Consensus 268 ~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~--------------~~~~ 306 (368) T 4EYK_A 268 AAYKKEFG---------------------------QRPGFMAVGGYDGIHLVFEALKKTGGK--------------ADGD 306 (368) T ss_dssp HHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHTTTC--------------CSHH T ss_pred HHHHHHHC---------------------------CCCChHHHHHHHHHHHHHHHHHHhCCC--------------CCHH Confidence 22222111 112345778999999999999886421 2345 Q NP_000836.2 441 ELLGYIRAVNFNGSAGTPVTFNEN-GDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 441 ~l~~~l~~~~f~G~~G~~v~Fd~~-G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .+.++|++.+|.|.+| ++.|+++ |++...+.+.+++..++...++.+|.|... T Consensus 307 ~v~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~i~~~~~~~g~~~~~~vg~~~~~ 360 (368) T 4EYK_A 307 SLIAAMKGMKWESPRG-PISIDPETRDIVQNIYIRKVEKVDGELYNIEFAKFDAV 360 (368) T ss_dssp HHHHHHTTCEEEETTE-EEEECTTTCCEEEEEEEEEEEEETTEEEEEEEEEEEEE T ss_pred HHHHHHhCCCccCCCc-ceEeCCCCCcccceEEEEEEEeeCCeEEEeEEEEecCC Confidence 6778888778999888 8999975 566667888888732223457888888754 No 71 >3HUT_A putative branched-chain amino acid ABC; Extracellular ligand-binding receptor,Transport protein,Receptor or; 1.93A {Rhodospirillum rubrum ATCC 11170} Probab=99.54 E-value=4e-19 Score=189.00 Aligned_cols=350 Identities=17% Similarity=0.219 Sum_probs=215.6 Template_Neff=12.100 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||++.|.++.. ...+.....+++.|++++|+.+++ .|.++++...|+.+++.. ..+.+++ T Consensus 2 ~~~~~Ig~i~~~~~~~----------~~~~~~~~~~~~~a~~~~n~~~~~-~g~~v~~~~~d~~~~~~~----~~~~~~~ 66 (358) T 3HUT_A 2 SLALLLGYELPLTGAN----------AAYGRVFQEAARLQLDRFNAAGGV-GGRPVDILYADSRDDADQ----ARTIARA 66 (358) T ss_dssp -CCEEEEEEECSSSTT----------HHHHHHHHHHHHHHHHHHHHTTTB-TTBCEEEEEEECTTCHHH----HHHHHHH T ss_pred CcceEEEEEecCCCCc----------HHHHHHHHHHHHHHHHHHHHcCCC-CCeeeEEEEecCCCCHHH----HHHHHHH Confidence 4678999999976532 124567889999999999987654 367788877776555332 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. ..+++++|++.++.....+...+...++|+|.++...+.+. ...++++++.++.... T Consensus 67 ~~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~--~~~~~~~~~~~~~~~~ 126 (358) T 3HUT_A 67 FVD------------------DPRVVGVLGDFSSTVSMAAGSIYGKEGMPQLSPTAAHPDYI--KISPWQFRAITTPAFE 126 (358) T ss_dssp HHH------------------CTTEEEEEECSSHHHHHHHHHHHHHHTCCEEESSCCCGGGT--TSCTTEEESSCCGGGH T ss_pred Hhh------------------CCCEEEEEcCCCcHHHHHHHHHHHHhCCCEEccCCCCcchh--ccCCCeeEecCCccch Confidence 332 14788899887766555666777888999998876554332 1246788999998888 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) ++.+++++.+.+|++|++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .+++++++.. T Consensus 127 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~~~ 202 (358) T 3HUT_A 127 GPNNAAWMIGDGFTSVAVIGVTTDWGLSSAQAFRKAFELR-GGAVVVNEEVP--PGNRRFDDVIDEIED-EAPQAIYLAM 202 (358) T ss_dssp HHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCCCCHHHHHHHHH-HCCSEEEEES T ss_pred HHHHHHHHHhCCCCEEEEEEeCChhhHHHHHHHHHHHHHc-CCeEeeEEEeC--CCCCCHHHHHHHHHh-hCCCEEEEeC Confidence 8899999887899999999976667778888888888775 35543322222 122345556666653 4788887776 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEF 362 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 362 (908) .+..+..+++++++.|+. ..+++.+.+...... ........+.+...... . ....+....|.+. T Consensus 203 ~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~---~~~~~~~~~f~~~ 266 (358) T 3HUT_A 203 AYEDAAPFLRALRARGSA--LPVYGSSALYSPKFI-DLGGPAVEGVRLATAFV----------L---GASDPVVVEFVSA 266 (358) T ss_dssp CHHHHHHHHHHHHHTTCC--CCEEECGGGCSHHHH-HHHGGGGTTCEEEESCC----------T---TCCSHHHHHHHHH T ss_pred CHHHHHHHHHHHHHCCCC--CCEEecchhcCHHHH-HhhcHHhCCeEEEEccc----------C---CCCCHHHHHHHHH Confidence 566677888888887773 345554433221110 00011122222111000 0 0000111122222 Q NP_000836.2 363 WEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKEL 442 (908) Q Consensus 363 ~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~l 442 (908) +++.++ ..++.++..+|||+++++.++++.... .++..+ T Consensus 267 ~~~~~~---------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~--------------~~~~~~ 305 (358) T 3HUT_A 267 YETLYG---------------------------AIPTLFAAHGYDAVGIMLAAVGRAGPE--------------VTRESL 305 (358) T ss_dssp HHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHCTT--------------CCHHHH T ss_pred HHHHHC---------------------------CCCCHHHHHHHHHHHHHHHHHHHhCCC--------------CCHHHH Confidence 221111 112345678999999999999876431 134567 Q NP_000836.2 443 LGYIRAV-NFNGSAGTPVTFNENGDA-PGRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 443 ~~~l~~~-~f~G~~G~~v~Fd~~G~~-~~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) .+.|++. .|.|.+| ++.|++++++ ...+.+++++ +++++.+|.|.. T Consensus 306 ~~~l~~~~~~~g~~G-~~~f~~~~~~~~~~~~~~~~~----~~~~~~~~~~~~ 353 (358) T 3HUT_A 306 RDALAATDRYAGVTG-ITRFDPETRETTKILTRLVVR----EGDFRVIDREGH 353 (358) T ss_dssp HHHHHTCCSEEETTE-EEEECTTTCCEEECCEEEEEE----TTEEEEC----- T ss_pred HHHHHcCCCccCCCe-eEEECCCCCccceeEEEEEEE----CCEEEEecCCCC Confidence 7778765 6899988 8999986543 4566777776 367888888864 No 72 >5KUH_C Glutamate receptor ionotropic, kainate 2; GluK2EM with LY466195, SIGNALING PROTEIN; HET: LY5; 11.6A {Rattus norvegicus} Probab=99.54 E-value=4.1e-19 Score=209.95 Aligned_cols=372 Identities=16% Similarity=0.193 Sum_probs=231.8 Template_Neff=11.700 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCS-RDTYALEQSLTFVQ 121 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~-~~~~a~~~~~~~~~ 121 (908) +++++||+++|.++.. .+.....|+++|++++|++++++++..+.+...|+.+ +...+ .+.+. T Consensus 2 ~~~i~Ig~~~p~sg~~------------~g~~~~~~~~~A~~~in~~~g~~~~~~~~~~~~~~~~~~~~~~----~~~~~ 65 (757) T 5KUH_C 2 THVLRFGGIFEYVESG------------PMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEA----SKKAC 65 (757) T ss_dssp CEEEEEEEEEEESSSC------------SCCHHHHHHHHHHHHHHHCSSSSSSEEEEEEEEEEETTCHHHH----HHHHH T ss_pred CceEEeEEEeecCCCC------------CCcHHHHHHHHHHHHHHcCcccCCCCeeeeeeEecCCCChHHH----HHHHH Confidence 4689999999998742 3567889999999999998877777888887777654 32211 11111 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +.. .++++++||+.++..+..++.+++..++|+|++.+.++.+.+ .+++++++.+++.. T Consensus 66 ~~~-------------------~~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~~ 124 (757) T 5KUH_C 66 DQL-------------------SLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDN--KDSFYVSLYPDFSS 124 (757) T ss_dssp HHH-------------------HHCCSCEECCSSHHHHHHHHHHHHHTTCCEEECSCCCCCTTC--CCCSEEEEEECHHH T ss_pred HHH-------------------HcCccEEEcCCChHHHHHHHHHHHHHCCCEEEeecCCCCCCC--CCceEEEccCCHHH Confidence 111 147899999998888888888999999999998876665443 36889999999988 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .+.++++++.+++|+++++++ ++.++....+.+.+.+.+. ++++... .++ .+..++...+++++. .++++|++. T Consensus 125 ~~~~l~~~~~~~~~~~v~ii~-~~~~~~~~~~~~~~~~~~~-g~~v~~~-~~~--~~~~~~~~~l~~l~~-~~~~~vv~~ 198 (757) T 5KUH_C 125 LSRAILDLVQFFKWKTVTVVY-DDSTGLIRLQELIKAPSRY-NLRLKIR-QLP--ADTKDAKPLLKEMKR-GKEFHVIFD 198 (757) T ss_dssp HHHHHHHHHHHTTCSEEEEEE-SSTHHHHHTHHHHTGGGTS-SCEEEEE-ECC--SSGGGCHHHHHHHHH-TTCCEEEEE T ss_pred HHHHHHHHHHHcCCCEEEEEE-eCchHHHHHHHHHhCcccc-CceEEEE-EcC--CCccccHHHHHHHHh-CCCEEEEEE Confidence 899999999888999999999 5556766677777766664 3555432 232 223456667777763 578999888 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) .....+..+++++++.|+.. .+.|+........... . .....+..... +.. .. ...+....+. T Consensus 199 ~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~-~--~~~~~~~~~~~--------~~~-~~----~~~~~~~~f~ 262 (757) T 5KUH_C 199 CSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDV-E--PYRYSGVNMTG--------FRI-LN----TENTQVSSII 262 (757) T ss_dssp SCHHHHHHHHHHHHHTTCCSTTCEEEECCTTGGGBCC-T--TTTTSCCEEEE--------EEC-SC----TTSHHHHHHH T ss_pred CCHHHHHHHHHHHHHcCCcCCCeEEEEeccCcccCCc-h--hhcccCcceEE--------EEE-ee----CCChHHHHHH Confidence 77777888999998888754 2345543211110000 0 00001100000 000 00 0011122233 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM-STIDG 439 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~-~~~~~ 439 (908) +.|++.+..... .+... .....+..++..+|||++++++|++++....+.. ..|... ...++ T Consensus 263 ~~~~~~~~~~~~----------~~~~~-----~~~~~~~~~~~~~ydav~~~~~al~~~~~~~~~~--~~~~~~~~~~~~ 325 (757) T 5KUH_C 263 EKWSMERLQAPP----------KPDSG-----LLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSS--LQCNRHKPWRFG 325 (757) T ss_dssp HHHHHHHTTSCC----------CSSSC-----BCTTCCCHHHHHHHHHHHHHHHHHHTCTTCCCCC--CCTTSCCCCTTH T ss_pred HHHHHhhcCCCC----------CCCCC-----CCCCCccHHHHHHHHHHHHHHHHHHhccccCCCc--cccCCCCcchhH Confidence 333322210000 00000 0001234567889999999999999876543211 112111 11244 Q NP_000836.2 440 KELLGYIRAVNFNGSAGTPVTFNENGDAPGR--YDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 440 ~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~--~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) ..+.+.|++..|.|.+| ++.||++|++... +.++++. ++.++.||.|.... T Consensus 326 ~~l~~~l~~~~~~g~~G-~i~f~~~~~~~~~~~~~~~~~~----~~~~~~vg~~~~~~ 378 (757) T 5KUH_C 326 TRFMSLIKEAHWEGLTG-RITFNKTNGLRTDFDLDVISLK----EEGLEKIGTWDPAS 378 (757) T ss_dssp HHHHHHHHTCEEEETTE-EEECCTTTSEECCCCEEEEEEE----TTEEEEEEEEETTT T ss_pred HHHHHHHHhcccCCccc-eeEecccCCeeeeeEEEEEEcc----cccceeeEEEECCC Confidence 56778888889999988 8999987777654 4444444 35789999998653 No 73 >4EVQ_A Putative ABC transporter subunit, substrate-binding; Structural Genomics, PSI-Biology, Midwest Center; HET: PHB, MSE, SO4, GOL; 1.4A {Rhodopseudomonas palustris} Probab=99.54 E-value=4.1e-19 Score=190.38 Aligned_cols=352 Identities=16% Similarity=0.137 Sum_probs=219.3 Template_Neff=11.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||+++|..+... ..+.....+++.+++++|. ...|+++++...|+.+++.. ..+ T Consensus 10 ~~~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~~---~~~g~~v~~~~~d~~~~~~~----~~~ 72 (375) T 4EVQ_A 10 SYAQAGALKVGLLLPYSGTYA----------PLGEAITRGLELYVQSQGG---KLGGRSISFVKVDDESAPPK----ATE 72 (375) T ss_dssp -----CCEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHTTT---EETTEEEEEEEEECTTCHHH----HHH T ss_pred cccCCCcEEEEEEeCCCCCch----------hhhHHHHHHHHHHHHhcCC---CcCCEEEEEEEecCCCChHH----HHH Confidence 446678999999999876421 2456788899999998753 22367788777776554322 233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++++. .++++++|++.++.....+...+...++|+|.+....+.+......++++++.++ T Consensus 73 ~~~~l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 134 (375) T 4EVQ_A 73 LTTKLIQ------------------SEKADVLIGTVHSGVAMAMVKIAREDGIPTIVPNAGADIITRAMCAPNVFRTSFA 134 (375) T ss_dssp HHHCCCC------------------CSCCSEEEECSSHHHHHHHHHHHHHHCCCEEESSCCCGGGGTTTCCTTEEESSCC T ss_pred HHHHHHH------------------cCCCCEEEEecCHHHHHHHHHHHHHhCCCEEEcCCCChhhcccccCCCEEEeecC Confidence 3333332 1578999987766655666677788899999887665443322235678888898 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) +...++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. ....+....+++++. .++|++ T Consensus 135 ~~~~~~~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i 210 (375) T 4EVQ_A 135 NGQIGRATGDAMIKAGLKKAVTVTWKYAAGEEMVSGFKKSFTAG-KGEVVKDITIA--FPDVEFQSALAEIAS-LKPDCV 210 (375) T ss_dssp HHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCCCCHHHHHHHHH-HCCSEE T ss_pred hhHHHHHHHHHHHHcCCCeEEEEeeCChHhHHHHHHHHHHHHhC-CCeEeeEEEec--CCCcchHHHHHHHHh-hCCCEE Confidence 88888899999887899999999866667777888888888765 35443322222 122345566677763 478888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW 358 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 358 (908) ++...+..+..+++++++.|+. ..+++.+.|..... ........+.+..... .. ....+.... T Consensus 211 i~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~----------~~---~~~~~~~~~ 273 (375) T 4EVQ_A 211 YAFFSGGGALKFIKDYAAANLG--IPLWGPGFLTDGVE--AAAGPAGDGIKTVLHY----------VS---DLDNAENQA 273 (375) T ss_dssp EEECCTHHHHHHHHHHHHTTCC--CCEEEEGGGTTTTH--HHHGGGGTTCEEEESC----------CT---TCCSHHHHH T ss_pred EEEeecchHHHHHHHHHHCCCC--CCEEeccccchhHH--HHHccccCCcEEEEec----------CC---CCCCHHHHH Confidence 8776566677888988888874 34554432221100 0001112222211110 00 000011112 Q NP_000836.2 359 FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTID 438 (908) Q Consensus 359 ~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~ 438 (908) |.+.+++.++ ..++.++..+||++++++.|++++... ..+ T Consensus 274 f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~~-------------~~~ 313 (375) T 4EVQ_A 274 FVKSFEAAYK---------------------------IPPDVFAVQGWDAGQLLDAGVKAVGGD-------------VAK 313 (375) T ss_dssp HHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHTTTC-------------TTC T ss_pred HHHHHHHHHC---------------------------CCCCHHHHHHHHHHHHHHHHHHHhCCC-------------ccc Confidence 2222222111 112356778999999999999987531 123 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHW 491 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~ 491 (908) ++.+.+.|++..|.|.+| ++.||++|++...+.+.+++ ++.++.+|.+ T Consensus 314 ~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~i~~~~----~~~~~~~~~~ 361 (375) T 4EVQ_A 314 RKELNAAMAAASFASPRG-PFKLSAAHNPVQNFYLRELK----GGKSVNLGLA 361 (375) T ss_dssp HHHHHHHHHTCEEEETTE-EEEBCTTSCBCCCEEEEEEE----TTEEEEEEEE T ss_pred HHHHHHHHHcCCCCCCCc-ceEeCCCCCeeeeEEEEEEE----CCeEEEeEEe Confidence 456778888888999999 89999888877778888887 3567777766 No 74 >4EVQ_B Putative ABC transporter subunit, substrate-binding; Structural Genomics, PSI-Biology, Midwest Center; HET: GOL, PHB, SO4; 1.4A {Rhodopseudomonas palustris} Probab=99.54 E-value=4.1e-19 Score=190.38 Aligned_cols=352 Identities=16% Similarity=0.137 Sum_probs=222.2 Template_Neff=11.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||+++|..+... ..+.....+++.+++++|. ...|+++++...|+.+++.. ..+ T Consensus 10 ~~~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~~---~~~g~~v~~~~~d~~~~~~~----~~~ 72 (375) T 4EVQ_B 10 SYAQAGALKVGLLLPYSGTYA----------PLGEAITRGLELYVQSQGG---KLGGRSISFVKVDDESAPPK----ATE 72 (375) T ss_dssp CHHHHCCEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHTTT---EETTEEEEEEEEECTTCHHH----HHH T ss_pred cccCCCcEEEEEEeCCCCCch----------hhhHHHHHHHHHHHHhcCC---CcCCEEEEEEEecCCCChHH----HHH Confidence 446678999999999876421 2456788899999998753 22367788777776554322 233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++++. .++++++|++.++.....+...+...++|+|.+....+.+......++++++.++ T Consensus 73 ~~~~l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 134 (375) T 4EVQ_B 73 LTTKLIQ------------------SEKADVLIGTVHSGVAMAMVKIAREDGIPTIVPNAGADIITRAMCAPNVFRTSFA 134 (375) T ss_dssp HHHCCCC------------------CSCCSEEEECSSHHHHHHHHHHHHHHCCCEEESSCCCGGGGTTTCCTTEEESSCC T ss_pred HHHHHHH------------------cCCCCEEEEecCHHHHHHHHHHHHHhCCCEEEcCCCChhhcccccCCCEEEeecC Confidence 3333332 1578999987766655666677788899999887665443322235678888898 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) +...++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. ....+....+++++. .++|++ T Consensus 135 ~~~~~~~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i 210 (375) T 4EVQ_B 135 NGQIGRATGDAMIKAGLKKAVTVTWKYAAGEEMVSGFKKSFTAG-KGEVVKDITIA--FPDVEFQSALAEIAS-LKPDCV 210 (375) T ss_dssp HHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCCCCHHHHHHHHH-HCCSEE T ss_pred hhHHHHHHHHHHHHcCCCeEEEEeeCChHhHHHHHHHHHHHHhC-CCeEeeEEEec--CCCcchHHHHHHHHh-hCCCEE Confidence 88888899999887899999999866667777888888888765 35443322222 122345566677763 478888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW 358 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 358 (908) ++...+..+..+++++++.|+. ..+++.+.|..... ........+.+..... .. ....+.... T Consensus 211 i~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~----------~~---~~~~~~~~~ 273 (375) T 4EVQ_B 211 YAFFSGGGALKFIKDYAAANLG--IPLWGPGFLTDGVE--AAAGPAGDGIKTVLHY----------VS---DLDNAENQA 273 (375) T ss_dssp EEECCTHHHHHHHHHHHHTTCC--CCEEEEGGGTTTTH--HHHGGGGTTCEEEESC----------CT---TCCSHHHHH T ss_pred EEEeecchHHHHHHHHHHCCCC--CCEEeccccchhHH--HHHccccCCcEEEEec----------CC---CCCCHHHHH Confidence 8776566677888988888874 34554432221100 0001112222211110 00 000011112 Q NP_000836.2 359 FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTID 438 (908) Q Consensus 359 ~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~ 438 (908) |.+.+++.++ ..++.++..+||++++++.|++++... ..+ T Consensus 274 f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~~-------------~~~ 313 (375) T 4EVQ_B 274 FVKSFEAAYK---------------------------IPPDVFAVQGWDAGQLLDAGVKAVGGD-------------VAK 313 (375) T ss_dssp HHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHTTTC-------------TTC T ss_pred HHHHHHHHHC---------------------------CCCCHHHHHHHHHHHHHHHHHHHhCCC-------------ccc Confidence 2222222111 112356778999999999999987531 123 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHW 491 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~ 491 (908) ++.+.+.|++..|.|.+| ++.||++|++...+.+.+++ ++.++.+|.+ T Consensus 314 ~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~i~~~~----~~~~~~~~~~ 361 (375) T 4EVQ_B 314 RKELNAAMAAASFASPRG-PFKLSAAHNPVQNFYLRELK----GGKSVNLGLA 361 (375) T ss_dssp HHHHHHHHHTCEEEETTE-EEEBCTTSCBCCCEEEEEEE----TTEEEEEEEE T ss_pred HHHHHHHHHcCCCCCCCc-ceEeCCCCCeeeeEEEEEEE----CCeEEEeEEe Confidence 456778888888999999 89999888877778888887 3567777766 No 75 >4N0Q_B Leu/Ile/Val-binding protein homolog 3; structural genomics, NIAID, National Institute; HET: LEU; 2.3A {Brucella melitensis} Probab=99.54 E-value=4.2e-19 Score=188.61 Aligned_cols=336 Identities=17% Similarity=0.229 Sum_probs=214.3 Template_Neff=11.900 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) ..+++||++.|+++... ..+.....+++.|++++|+.+++. |.++++.+.|+.+++.. ..+.+++ T Consensus 8 ~~~~~ig~~~p~sg~~~----------~~~~~~~~g~~~a~~~~n~~~~~~-g~~i~~~~~d~~~~~~~----~~~~~~~ 72 (354) T 4N0Q_B 8 HADITIGVIAPLTGPVA----------AFGDQVKKGAETAVEVINKAGGIK-GEKVVLKFADDAGEPKQ----GVSAANQ 72 (354) T ss_dssp -CCEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHHTTTBT-TBCEEEEEEECTTCHHH----HHHHHHH T ss_pred ccCeEEEEEEcCCCCcH----------HHHHHHHHHHHHHHHHHHHccCCC-CeeEEEEEecCCCCHHH----HHHHHHH Confidence 35789999999987642 366788999999999999876543 67888888887665432 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. ++++++|++.++.....+...+...++|+|.+....+.+... .+++++++.+++... T Consensus 73 l~~-------------------~~v~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~~~~ 132 (354) T 4N0Q_B 73 IVG-------------------DGIKFVVGLVTTGVAVPVSDVLSENGVLMVTPTATGPDLTAR-GLENVFRTCGRDGQQ 132 (354) T ss_dssp HHH-------------------TTCCEEEECCSHHHHHHHHHHHHHTTCEEEESSCCCGGGGSS-CCSSEEESSCCHHHH T ss_pred HHh-------------------CCCCEEEEcCCcccHHHHHHHHHHcCCEEEecccCCcchhhc-CCCceeecCCChHHH Confidence 332 478899987766655566677788899999987655443321 256788999998888 Q NP_000836.2 203 AQAMVDIV-TALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 203 ~~~~~~~l-~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) ++.+++++ ++++|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++|++++. T Consensus 133 ~~~~~~~l~~~~~~~~i~~l~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~vi~~ 208 (354) T 4N0Q_B 133 AEVMADYVLKNMKDKKVAVIHDKGAYGKGLADAFKAAINKG-GITEVHYDSVT--PGDKDFSALVTKLKS-AGAEVVYFG 208 (354) T ss_dssp HHHHHHHHHHHCTTSCEEEEECSSHHHHHHHHHHHHHHHHT-TCCCSEEEECC--TTCCCCHHHHHHHHH-TTCSEEEEE T ss_pred HHHHHHHHHHhcCCCEEEEEECCCHhhHHHHHHHHHHHHhC-CCeeeEEEeeC--CCCCChHHHHHHHHH-CCCCEEEEe Confidence 99999988 45689999999976667777888888888775 45544322222 122344555666653 578888777 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAE 361 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 361 (908) ..+..+..+++++++.|+. +.|++.+.|...... ........+....... . . ...+.+.+ T Consensus 209 ~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~---~---~~~~~~~~ 268 (354) T 4N0Q_B 209 GYHAEGGLLSRQLHDAGMQ--ALVLGGEGLSNTEYW-AIGGTNAQGTLFTNAK-----------D---A---TKNPAAKD 268 (354) T ss_dssp SCHHHHHHHHHHHHHTTCC--CEEEECGGGCSHHHH-HHHGGGGTTCEEEEEC-----------C---G---GGSGGGHH T ss_pred cCchhHHHHHHHHHHcCCC--cEEEeccccCCHHHH-HhhcccccCcEEecCC-----------c---c---CCCHHHHH Confidence 6566677888888888773 466665544322110 0001111222111100 0 0 01111222 Q NP_000836.2 362 FWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKE 441 (908) Q Consensus 362 ~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~ 441 (908) +.++ +.. .. ..++.++..+|||++++++|++++... .+++. T Consensus 269 f~~~-~~~-~~-----------------------~~~~~~~~~~yda~~~~~~a~~~~~~~--------------~~~~~ 309 (354) T 4N0Q_B 269 AIQA-LKA-KN-----------------------IPAEAFTMNAYAAVEVIKAGIERAGST--------------DDSAA 309 (354) T ss_dssp HHHH-HHH-TT-----------------------CCCCHHHHHHHHHHHHHHHHHHHHTCS--------------SCHHH T ss_pred HHHH-HHH-cC-----------------------CCCChHHHHHHHHHHHHHHHHHHhCCC--------------CCHHH Confidence 2221 110 00 112356778999999999999886431 13445 Q NP_000836.2 442 LLGYIRA-VNFNGSAGTPVTFNENGDAP-GRYDIFQYQ 477 (908) Q Consensus 442 l~~~l~~-~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~ 477 (908) +.++|++ ..|.|.+| .+.|+++|++. ..+.+++++ T Consensus 310 ~~~~l~~~~~~~g~~g-~i~f~~~g~~~~~~~~i~~~~ 346 (354) T 4N0Q_B 310 VAKALHDGKPIETAIG-TLTYSETGDLSSPSFDIFKWD 346 (354) T ss_dssp HHHHHTSSCCEEETTE-EECBCTTSCBSSCCEEEEEEE T ss_pred HHHHHhcCCCCcccee-EEEeCCCCCCCCCeeEEEEEE Confidence 7777865 57899988 89999888875 356777776 No 76 >4N0Q_C Leu/Ile/Val-binding protein homolog 3; structural genomics, NIAID, National Institute; HET: LEU; 2.3A {Brucella melitensis} Probab=99.54 E-value=4.2e-19 Score=188.61 Aligned_cols=336 Identities=17% Similarity=0.229 Sum_probs=213.8 Template_Neff=11.900 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) ..+++||++.|+++... ..+.....+++.|++++|+.+++. |.++++.+.|+.+++.. ..+.+++ T Consensus 8 ~~~~~ig~~~p~sg~~~----------~~~~~~~~g~~~a~~~~n~~~~~~-g~~i~~~~~d~~~~~~~----~~~~~~~ 72 (354) T 4N0Q_C 8 HADITIGVIAPLTGPVA----------AFGDQVKKGAETAVEVINKAGGIK-GEKVVLKFADDAGEPKQ----GVSAANQ 72 (354) T ss_dssp --CEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHHTTCSS-SCCEEEEEEECTTCHHH----HHHHHHH T ss_pred ccCeEEEEEEcCCCCcH----------HHHHHHHHHHHHHHHHHHHccCCC-CeeEEEEEecCCCCHHH----HHHHHHH Confidence 35789999999987642 366788999999999999876543 67888888887665432 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. ++++++|++.++.....+...+...++|+|.+....+.+... .+++++++.+++... T Consensus 73 l~~-------------------~~v~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~~~~ 132 (354) T 4N0Q_C 73 IVG-------------------DGIKFVVGLVTTGVAVPVSDVLSENGVLMVTPTATGPDLTAR-GLENVFRTCGRDGQQ 132 (354) T ss_dssp HHH-------------------TTCCEEEECCSHHHHHHHHHHHHHTTCEEEESSCCCGGGSSS-CCSSEEESSCCHHHH T ss_pred HHh-------------------CCCCEEEEcCCcccHHHHHHHHHHcCCEEEecccCCcchhhc-CCCceeecCCChHHH Confidence 332 478899987766655566677788899999987655443321 256788999998888 Q NP_000836.2 203 AQAMVDIV-TALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 203 ~~~~~~~l-~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) ++.+++++ ++++|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++|++++. T Consensus 133 ~~~~~~~l~~~~~~~~i~~l~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~vi~~ 208 (354) T 4N0Q_C 133 AEVMADYVLKNMKDKKVAVIHDKGAYGKGLADAFKAAINKG-GITEVHYDSVT--PGDKDFSALVTKLKS-AGAEVVYFG 208 (354) T ss_dssp HHHHHHHHHHHCTTSCEEEEECSSHHHHHHHHHHHHHHHHH-TCCCSEEEECC--TTCCCCHHHHHHHHH-TTCSEEEEE T ss_pred HHHHHHHHHHhcCCCEEEEEECCCHhhHHHHHHHHHHHHhC-CCeeeEEEeeC--CCCCChHHHHHHHHH-CCCCEEEEe Confidence 99999988 45689999999976667777888888888775 45544322222 122344555666653 578888777 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAE 361 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 361 (908) ..+..+..+++++++.|+. +.|++.+.|...... ........+....... . . ...+.+.+ T Consensus 209 ~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~---~---~~~~~~~~ 268 (354) T 4N0Q_C 209 GYHAEGGLLSRQLHDAGMQ--ALVLGGEGLSNTEYW-AIGGTNAQGTLFTNAK-----------D---A---TKNPAAKD 268 (354) T ss_dssp SCHHHHHHHHHHHHHTTCC--CEEEECGGGCSHHHH-HHHGGGGTTCEEEEEC-----------C---S---TTSGGGHH T ss_pred cCchhHHHHHHHHHHcCCC--cEEEeccccCCHHHH-HhhcccccCcEEecCC-----------c---c---CCCHHHHH Confidence 6566677888888888773 466665544322110 0001111222111100 0 0 01111222 Q NP_000836.2 362 FWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKE 441 (908) Q Consensus 362 ~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~ 441 (908) +.++ +.. .. ..++.++..+|||++++++|++++... .+++. T Consensus 269 f~~~-~~~-~~-----------------------~~~~~~~~~~yda~~~~~~a~~~~~~~--------------~~~~~ 309 (354) T 4N0Q_C 269 AIQA-LKA-KN-----------------------IPAEAFTMNAYAAVEVIKAGIERAGST--------------DDSAA 309 (354) T ss_dssp HHHH-HHH-TT-----------------------CCCCHHHHHHHHHHHHHHHHHHHHTCS--------------SCHHH T ss_pred HHHH-HHH-cC-----------------------CCCChHHHHHHHHHHHHHHHHHHhCCC--------------CCHHH Confidence 2221 110 00 112356778999999999999886431 13445 Q NP_000836.2 442 LLGYIRA-VNFNGSAGTPVTFNENGDAP-GRYDIFQYQ 477 (908) Q Consensus 442 l~~~l~~-~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~ 477 (908) +.++|++ ..|.|.+| .+.|+++|++. ..+.+++++ T Consensus 310 ~~~~l~~~~~~~g~~g-~i~f~~~g~~~~~~~~i~~~~ 346 (354) T 4N0Q_C 310 VAKALHDGKPIETAIG-TLTYSETGDLSSPSFDIFKWD 346 (354) T ss_dssp HHHHHHSCCCEEETTE-EECBCTTSCBSSCCEEEEEEE T ss_pred HHHHHhcCCCCcccee-EEEeCCCCCCCCCeeEEEEEE Confidence 7777865 57899988 89999888875 356777776 No 77 >3SAJ_C Glutamate receptor 1; Rossmann fold, ion channel, membrane; HET: BMA, MAN, NAG; 2.5A {Rattus norvegicus} Probab=99.54 E-value=4.5e-19 Score=190.74 Aligned_cols=357 Identities=17% Similarity=0.268 Sum_probs=218.4 Template_Neff=11.900 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||+++|.++ .....|+++|++++|+++++++++++ +...|+.. ..+.+ T Consensus 6 ~~~~~i~Ig~~~~~~~----------------~~~~~~~~~a~~~~n~~~~~~~~~~~-~~~~d~~~--------~~~~~ 60 (384) T 3SAJ_C 6 AMPNNIQIGGLFPNQQ----------------SQEHAAFRFALSQLTEPPKLLPQIDI-VNISDSFE--------MTYRF 60 (384) T ss_pred cCCCCEEEEEEcCCCc----------------HHHHHHHHHHHHHHHHcCCCCCCEEE-EEEcCcHH--------HHHHH Confidence 4567899999999875 24668999999999987766555555 44444321 11122 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) .+++. ++++++||+.++..+..++..+...++|+|++.+.... ..++++. .+++ T Consensus 61 ~~~~~-------------------~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~-----~~~~~~~-~~~~- 114 (384) T 3SAJ_C 61 CSQFS-------------------KGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDT-----SNQFVLQ-LRPE- 114 (384) T ss_pred HHHHh-------------------cCCCEEECCCCHHHHHHHHHHHHHhCCCEEeCCCCCCC-----CCCccee-cCHH- Confidence 22221 47889999888877777788889999999998754321 1233333 4333 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) .+.++++++++++|++|++++ ++.++....+.+++.+++. ++++.....++ .+..++...+++++. .++|+|++ T Consensus 115 -~~~~~~~~~~~~~~~~v~ii~-~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~ 188 (384) T 3SAJ_C 115 -LQEALISIIDHYKWQTFVYIY-DADRGLSVLQRVLDTAAEK-NWQVTAVNILT--TTEEGYRMLFQDLEK-KKERLVVV 188 (384) T ss_pred -HHHHHHHHHHHhCCCEEEEEe-cChhhHHHHHHHHHHHHHc-CCeEEEEEecC--CCCCCcHHHHHHHHH-hCCCEEEE Confidence 678888888888999999999 6677877788888887775 35554433332 122456666777763 57899988 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSD-SWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW 358 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~-~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 358 (908) .........+++++++.|+.. .+.|+..+ .|..... ........+...... + . ...+.... T Consensus 189 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~~~~~~----------~-~----~~~~~~~~ 251 (384) T 3SAJ_C 189 DCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDL--NKFKESGANVTGFQL----------V-N----YTDTIPAR 251 (384) T ss_pred eCCHHHHHHHHHHHHHCCCCCCCeEEEEeCCCcCCCch--HHhhhcccccceeEe----------e-C----CCCcccHH Confidence 877777788999998888753 46677654 2322110 000000111111000 0 0 00111122 Q NP_000836.2 359 FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG----YIGLCPRM 434 (908) Q Consensus 359 ~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~----~~~~~~~~ 434 (908) +.+.|++.+.. .|.... ...+..++..+|||++++++++++.....+.. ....|... T Consensus 252 f~~~~~~~~~~-------------~~~~~~------~~~~~~~~~~~ydav~~~~~al~~~~~~~~~~~~~~~~~~c~~~ 312 (384) T 3SAJ_C 252 IMQQWRTSDSR-------------DHTRVD------WKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLAN 312 (384) T ss_pred HHHHHHHHHCC-------------CCCCCC------CCCCChHHHHHHHHHHHHHHHHHHHHhcCCCCCCCCCCCccCCC Confidence 33333333221 010000 01234567889999999999999987543210 01122211 Q NP_000836.2 435 ---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 435 ---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) ...++..+.+.|++..|.|.+| ++.||++|++.. .+.+++++ ++.++.||.|+... T Consensus 313 ~~~~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~ 372 (384) T 3SAJ_C 313 PAVPWGQGIDIQRALQQVRFEGLTG-NVQFNEKGRRTNYTLHVIEMK----HDGIRKIGYWNEDD 372 (384) T ss_pred CCCCccCHHHHHHHHhcCCcccCCc-cEEEcCCCCCCCeeEEEEEee----CCcEEEeEEEeCCC Confidence 0114456778888889999998 899999998753 56666665 35789999998653 No 78 >6E7R_B Glutamate receptor ionotropic, NMDA 1; NMDA Receptor, Ion channel, Allosteric; HET: HYS, CL, MAN, NAG, BMA; 2.1A {Xenopus laevis} Probab=99.53 E-value=6e-19 Score=188.06 Aligned_cols=348 Identities=15% Similarity=0.202 Sum_probs=223.3 Template_Neff=12.000 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ++++||+++|.. ....|++.|++++|+.++++ |.++++... +.+++.. ..+.+.++ T Consensus 2 ~~i~ig~~~~~~------------------~~~~~~~~a~~~in~~~~~~-g~~i~l~~~-~~~~~~~----~~~~~~~l 57 (363) T 6E7R_B 2 PSIGIAVILVGT------------------SDEVAIKDAHEKDDFHHLSV-VPRVELVAM-NETDPKS----IITRICDL 57 (363) T ss_dssp CEEEEEEEEESS------------------CCHHHHHHHTTGGGGCCSSS-EEEEEEEEE-CCCSHHH----HHHHHHHH T ss_pred CceeEEEEEeCC------------------chhHHHHHHHHhcCCCCCcc-CCcEEEEEc-CCCCHHH----HHHHHHHH Confidence 578999998621 35678999999999877654 567777666 4444332 22333333 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVI--GAAASSV-SIMVANILRLFKIPQISYASTA-PELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vI--g~~~s~~-~~~va~~~~~~~iP~Is~~~~~-~~l~~~~~~~~~~~~~~~~ 199 (908) +. .++++++| |+.++.. +..+...+...++|+|++.+.. ..+++...+++++++.+++ T Consensus 58 ~~------------------~~~v~~vi~~g~~~s~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~ 119 (363) T 6E7R_B 58 MS------------------DRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSI 119 (363) T ss_dssp HH------------------HSCEEEEEEEESSCCTHHHHHHHHHHHHHTCCEEEEEGGGGSCCCSCCTTCCEEESSCCH T ss_pred Hh------------------hCCceEEEEcCCCCHHHHHHHHHHHHHhhCCCEEEecCCCcccccCCCccceeEEcCCCH Confidence 32 14789999 8877753 6677778888999999887643 2333333578999999999 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPR-PGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~-~~~~~~~~~~l~~~~~~~vi 278 (908) ...++++++++.+++|+++++++.+++++....+.+++.+++. ++++.....++.... ..++...+++++. .++++| T Consensus 120 ~~~~~~~~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~i~~-~~~~~v 197 (363) T 6E7R_B 120 EQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENS-FVGWELEEVLLLDMSLDDGDSKIQNQLKK-LQSPII 197 (363) T ss_dssp HHHHHHHHHHHHHTTCCEEEEEECSSTTHHHHHHHHHHHHHTS-SSCCEEEEEEECCTTSCCTTCHHHHHHTT-CCCSEE T ss_pred HHHHHHHHHHHHHcCCeEEEEEEEcCCChHHHHHHHHHHHhhc-CCCeEEEEEEEecCCCCCchHHHHHHHHh-CCCCEE Confidence 9899999999988899999999987778887888888877765 355543222211011 2245566777763 578988 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) ++......+..+++++++.|+.. ++.|+..+.+...... . ......+.+.+ T Consensus 198 v~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~-~~~~~~g~~~~-------------------------- 249 (363) T 6E7R_B 198 LLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDT-V-PSEFPTGLISV-------------------------- 249 (363) T ss_dssp EEESCHHHHHHHHHHHHHTTCSSTTCEEEECHHHHCSTTC-C-CTTSCTTCEEE-------------------------- T ss_pred EEeCCHHHHHHHHHHHHHcCCCCCCeEEEeecCCCCCCCC-C-CccCCCceEEE-------------------------- Confidence 88877777788899888888753 4567665422211000 0 00000110000 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG--YIGLCPRM- 434 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~--~~~~~~~~- 434 (908) .+ . .+ ...++..+|||++++++|++++....+.. ....|... T Consensus 250 ~~----~-~~------------------------------~~~~~~~~ydav~~~~~al~~~~~~~~~~~~~~~~c~~~~ 294 (363) T 6E7R_B 250 SY----D-EW------------------------------DYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTH 294 (363) T ss_dssp EC----S-SS------------------------------SSCHHHHHHHHHHHHHHHHHHHHHHHSCCCCCCSCSTTTT T ss_pred ee----c-cc------------------------------ccChhHHHHHHHHHHHHHHHHHHhhcCCCCCCCccccCCC Confidence 00 0 00 01235678999999999999987532110 01122211 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ...++..+.++|++..|.| | ++.|+++|++. ..+.|++++. ...++.||.|+... ++...+.|+ T Consensus 295 ~~~~~~~~~l~~~l~~~~~~g--g-~i~f~~~g~~~~~~~~i~~~~~---~~~~~~vg~w~~~~-l~~~~~~w~ 361 (363) T 6E7R_B 295 EKRIYQSNMLNRYLINVTFEG--R-DLSFSEDGYQMHPKLVIILLNK---ERKWERVGKWKDKS-LQMKYYVWP 361 (363) T ss_dssp GGGGGCCCTTHHHHTSCEETT--E-ECCBCTTSBBSSCCEEEEEECT---TSCEEEEEEEETTE-EEESCSSCC T ss_pred cccchhhHHHHHHHcceEecC--e-eeeeCCCCccccceEEEEEeeC---CCceEEEEEEECCe-eEeeceecC Confidence 1124556778888888987 7 89999999875 5788888873 25688999998762 333346663 No 79 >6E7S_D Glutamate receptor ionotropic, NMDA 1; NMDA Receptor, Ion channel, Allosteric; HET: MAN, HZ4, NAG, BMA; 2.72A {Xenopus laevis} Probab=99.53 E-value=6e-19 Score=188.06 Aligned_cols=348 Identities=15% Similarity=0.202 Sum_probs=223.3 Template_Neff=12.000 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ++++||+++|.. ....|++.|++++|+.++++ |.++++... +.+++.. ..+.+.++ T Consensus 2 ~~i~ig~~~~~~------------------~~~~~~~~a~~~in~~~~~~-g~~i~l~~~-~~~~~~~----~~~~~~~l 57 (363) T 6E7S_D 2 PSIGIAVILVGT------------------SDEVAIKDAHEKDDFHHLSV-VPRVELVAM-NETDPKS----IITRICDL 57 (363) T ss_dssp CEEEEEEEEESS------------------CCHHHHHHHHTTTTTCCSSC-EEEEEEEEE-SCCSHHH----HHHHHHHH T ss_pred CceeEEEEEeCC------------------chhHHHHHHHHhcCCCCCcc-CCcEEEEEc-CCCCHHH----HHHHHHHH Confidence 578999998621 35678999999999877654 567777666 4444332 22333333 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVI--GAAASSV-SIMVANILRLFKIPQISYASTA-PELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vI--g~~~s~~-~~~va~~~~~~~iP~Is~~~~~-~~l~~~~~~~~~~~~~~~~ 199 (908) +. .++++++| |+.++.. +..+...+...++|+|++.+.. ..+++...+++++++.+++ T Consensus 58 ~~------------------~~~v~~vi~~g~~~s~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~ 119 (363) T 6E7S_D 58 MS------------------DRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSI 119 (363) T ss_dssp HH------------------HSCEEEEEEECSSCCTHHHHHHHHHHHHHTCCEEEEEGGGGSCCCSCCTTCCEEESSCCH T ss_pred Hh------------------hCCceEEEEcCCCCHHHHHHHHHHHHHhhCCCEEEecCCCcccccCCCccceeEEcCCCH Confidence 32 14789999 8877753 6677778888999999887643 2333333578999999999 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPR-PGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~-~~~~~~~~~~l~~~~~~~vi 278 (908) ...++++++++.+++|+++++++.+++++....+.+++.+++. ++++.....++.... ..++...+++++. .++++| T Consensus 120 ~~~~~~~~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~i~~-~~~~~v 197 (363) T 6E7S_D 120 EQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENS-FVGWELEEVLLLDMSLDDGDSKIQNQLKK-LQSPII 197 (363) T ss_dssp HHHHHHHHHHHHHTTCCEEEEEECSSTTHHHHHHHHHHHHHSC-SSCCEEEEEEECCTTSCCTTCHHHHHHTT-CCCSEE T ss_pred HHHHHHHHHHHHHcCCeEEEEEEEcCCChHHHHHHHHHHHhhc-CCCeEEEEEEEecCCCCCchHHHHHHHHh-CCCCEE Confidence 9899999999988899999999987778887888888877765 355543222211011 2245566777763 578988 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) ++......+..+++++++.|+.. ++.|+..+.+...... . ......+.+.+ T Consensus 198 v~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~-~~~~~~g~~~~-------------------------- 249 (363) T 6E7S_D 198 LLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDT-V-PSEFPTGLISV-------------------------- 249 (363) T ss_dssp EEESCHHHHHHHHHHHHHTTCSSTTCEEEECHHHHCSTTC-C-CTTSCTTCEEE-------------------------- T ss_pred EEeCCHHHHHHHHHHHHHcCCCCCCeEEEeecCCCCCCCC-C-CccCCCceEEE-------------------------- Confidence 88877777788899888888753 4567665422211000 0 00000110000 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG--YIGLCPRM- 434 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~--~~~~~~~~- 434 (908) .+ . .+ ...++..+|||++++++|++++....+.. ....|... T Consensus 250 ~~----~-~~------------------------------~~~~~~~~ydav~~~~~al~~~~~~~~~~~~~~~~c~~~~ 294 (363) T 6E7S_D 250 SY----D-EW------------------------------DYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTH 294 (363) T ss_dssp EC----T-TS------------------------------SSCHHHHHHHHHHHHHHHHHHHHHHHSCCCCCCSCSTTTT T ss_pred ee----c-cc------------------------------ccChhHHHHHHHHHHHHHHHHHHhhcCCCCCCCccccCCC Confidence 00 0 00 01235678999999999999987532110 01122211 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ...++..+.++|++..|.| | ++.|+++|++. ..+.|++++. ...++.||.|+... ++...+.|+ T Consensus 295 ~~~~~~~~~l~~~l~~~~~~g--g-~i~f~~~g~~~~~~~~i~~~~~---~~~~~~vg~w~~~~-l~~~~~~w~ 361 (363) T 6E7S_D 295 EKRIYQSNMLNRYLINVTFEG--R-DLSFSEDGYQMHPKLVIILLNK---ERKWERVGKWKDKS-LQMKYYVWP 361 (363) T ss_dssp TTTTTCCSTTHHHHTSCEETT--E-ECCBCTTSBBSSCCEEEEEECT---TSCEEEEEEEETTE-EEESCSSCC T ss_pred cccchhhHHHHHHHcceEecC--e-eeeeCCCCccccceEEEEEeeC---CCceEEEEEEECCe-eEeeceecC Confidence 1124556778888888987 7 89999999875 5788888873 25688999998762 333346663 No 80 >3HSY_B Glutamate receptor 2; GLUTAMATE RECEPTOR, LIGAND-GATED ION CHANNEL; HET: BMA, NAG, SO4; 1.75A {Rattus norvegicus} Probab=99.53 E-value=6.1e-19 Score=188.94 Aligned_cols=357 Identities=15% Similarity=0.172 Sum_probs=218.5 Template_Neff=12.200 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI-LDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~-~d~~~~~~~a~~~~~~~~~~ 122 (908) ++++||+++|.++. ....|+++|++++|+. |+++++.+ .|+.+++.. +.+.+.+ T Consensus 1 ~~i~Ig~~~~~~~~----------------~~~~~~~~a~~~~n~~-----g~~i~~~~~~~~~~~~~~----~~~~~~~ 55 (376) T 3HSY_B 1 NSIQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFA----VTNAFCS 55 (376) T ss_dssp CEEEEEEEEETTCH----------------HHHHHHHHHHHHHCCS-----SCEEEEEEEEECTTCHHH----HHHHHHH T ss_pred CceeEEEEecCCCh----------------HHHHHHHHHHHHhcCC-----CceeceeEEecCCCChHH----HHHHHHH Confidence 36899999998752 4678999999999975 35677765 344444332 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. ++++++||+.++.....++.+++..++|+|++..... ..+++++++.|+ . T Consensus 56 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~p~---~ 108 (376) T 3HSY_B 56 QFS-------------------RGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPD---L 108 (376) T ss_dssp HHH-------------------HTCSEEEECCCTTTHHHHHHHHHHHTCEEEECSCCCS-----SCCTTEEECSCC---C T ss_pred HHh-------------------cCeeEEEecCChHHHHHHHHHHhhcCCeEEecCCCCC-----CCCCcEEEecCC---H Confidence 332 4788999998887777888889999999998764332 246889999887 3 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE--PRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~--~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ++++++++.+++|+++++++.++ ++....+.+.+.+++. ++++......+.. .+..++...+++++. .++++|++ T Consensus 109 ~~~~~~~l~~~~~~~v~il~~~~-~~~~~~~~~~~~~~~~-~~~v~~~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vv~ 185 (376) T 3HSY_B 109 KGALLSLIEYYQWDKFAYLYDSD-RGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKERRVIL 185 (376) T ss_dssp HHHHHHHHHHTTCCEEEEEECTT-TCSHHHHHHHHHHHHH-TCEEEEEEGGGTTSTTHHHHHHHHHCCCCC-SCCCEEEE T ss_pred HHHHHHHHHHhCCCEEEEEEeCc-chHHHHHHHHHHHhhc-CceEEEEEeecCCCCCCccchHHHHHHccc-cCCcEEEE Confidence 67778888888999999999665 7777777777777664 3555432221100 112345666777763 57899888 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) .+.......+++++++.|+.. .+.|+..+........ ........+...+... . ...+....| T Consensus 186 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~----~~~~~~~~f 249 (376) T 3HSY_B 186 DCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGANVSGFQIV-----------D----YDDSLVSKF 249 (376) T ss_dssp CSCGGGHHHHHHHHHHHSSSGGGCEEEECSSBGGGSCC-CTTTTTTCEEEEEESS-----------C----TTSHHHHHH T ss_pred ECCHHHHHHHHHHHHHhCCCcCCeEEEEecCCCCcccH-HHhccCCeeEEEEEEe-----------c----CCChHHHHH Confidence 877777888999998888753 3456655321111000 0000001111111000 0 001111223 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG----YIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~----~~~~~~~~- 434 (908) .+.+++.+..... .. ....+..++..+|||++++++|++++....+.. ....|... T Consensus 250 ~~~~~~~~~~~~~----------~~---------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~c~~~~ 310 (376) T 3HSY_B 250 IERWSTLEEKEYP----------GA---------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANP 310 (376) T ss_dssp HHHHTTSCTTTST----------TC---------SSSCCCHHHHHHHHHHHHHHHHHTTSCCCCCCCCCCCCTTHHHHSC T ss_pred HHHHHccChhhCC----------CC---------CCCCCChHHHHHHHHHHHHHHHHHHHHhcccccccCCCCCccCCCC Confidence 3333322211000 00 001234567889999999999999876432110 00122110 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) ...++..+.+.|++..|.|.+| ++.|+++|++.. .+.+++++ .+.++.+|.|.... T Consensus 311 ~~~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~ 369 (376) T 3HSY_B 311 AVPWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEVD 369 (376) T ss_dssp CCCHHHHHHHHHHHHTCCEEETTE-EECBCTTSCBCSCEEEEEEEE----TTEEEEEEEEETTT T ss_pred CCCchhhHHHHHHHhcCCcccCCe-eEEECCCCceeeeEEEEEEee----cCCcEEEEEEeCCC Confidence 0124556778888889999988 899999898875 88888887 25688999998653 No 81 >3SAJ_B Glutamate receptor 1; Rossmann fold, ion channel, membrane; HET: MAN, BMA, NAG; 2.5A {Rattus norvegicus} Probab=99.53 E-value=6.5e-19 Score=189.48 Aligned_cols=357 Identities=17% Similarity=0.268 Sum_probs=217.5 Template_Neff=11.900 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||+++|.++ .....|+++|++++|+++++++++++ +...|+.. ..+.+ T Consensus 6 ~~~~~i~ig~~~p~~~----------------~~~~~~~~~a~~~~n~~~~~~~~~~~-~~~~d~~~--------~~~~~ 60 (384) T 3SAJ_B 6 AMPNNIQIGGLFPNQQ----------------SQEHAAFRFALSQLTEPPKLLPQIDI-VNISDSFE--------MTYRF 60 (384) T ss_dssp CCCSEEEEEEEESSSS----------------CHHHHHHHHHHHTCCSSSEEEEEEEE-CCTTCHHH--------HHHHH T ss_pred CCCCceeEEEEeCCCC----------------hHHHHHHHHHHHHccCCCccCCccEE-ecCCcHHH--------HHHHH Confidence 4567899999999875 24668999999999987766655555 44444321 11122 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) .+++. ++++++||+.++..+..++..+...++|+|++.+.... ..++++. .+++ T Consensus 61 ~~~~~-------------------~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~-----~~~~~~~-~~~~- 114 (384) T 3SAJ_B 61 CSQFS-------------------KGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDT-----SNQFVLQ-LRPE- 114 (384) T ss_dssp HHHHH-------------------HTCSCEEECCCTTTHHHHHHHHHHHTCCEEECSCCCSS-----CCTTEEE-CSCC- T ss_pred HHhhh-------------------cCeEEEEecCCHHHHHHHHHHHhhcCCcEEeCCCCCCC-----CCceEEE-echh- Confidence 22221 47889999888877777788889999999998754321 1233333 3333 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) .+.++++++++++|++|++++ ++.++....+.+++.+++. ++++.....++ .+..++...+++++. .++|+|++ T Consensus 115 -~~~~~~~~~~~~~~~~v~vi~-~~~~~~~~~~~~~~~~~~~-~~~v~~~~~~~--~~~~~~~~~~~~~~~-~~~~~iv~ 188 (384) T 3SAJ_B 115 -LQEALISIIDHYKWQTFVYIY-DADRGLSVLQRVLDTAAEK-NWQVTAVNILT--TTEEGYRMLFQDLEK-KKERLVVV 188 (384) T ss_dssp -CHHHHHHHHHHHTCCEEEEEE-CHHHHTTHHHHHHHHHHHH-TCEEEEEETTT--CCHHHHHHHHHHHHH-SSSCEEEE T ss_pred -HHHHHHHHHHHcCCCEEEEEE-cCccchHHHHHHHHHHHhc-CCceEEEEecc--CCccchHHHHHHHhh-cCCcEEEE Confidence 678888888888999999999 6677877788888877765 35554433232 122355666777763 57899888 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSD-SWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW 358 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~-~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 358 (908) .........+++++++.|+.. .+.|+..+ .|..... ........+...... + . ...+.... T Consensus 189 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~~~~~~----------~-~----~~~~~~~~ 251 (384) T 3SAJ_B 189 DCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDL--NKFKESGANVTGFQL----------V-N----YTDTIPAR 251 (384) T ss_dssp ECCHHHHHHHHHHHHHTTCSSTTCEEEEECSBTTSSCC--SSSTTTSCEEEEEEC----------C-C----TTSHHHHH T ss_pred ECCHHHHHHHHHHHHHhccccCCeEEEEeeCCccccCH--HHHhccCCceEEEEE----------E-c----CCCchHHH Confidence 877777788999998888753 46677654 2322110 000000111111000 0 0 00111222 Q NP_000836.2 359 FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG----YIGLCPRM 434 (908) Q Consensus 359 ~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~----~~~~~~~~ 434 (908) +.+.|++.+.. .|.... ...+..++..+|||++++++++++.....+.. ....|... T Consensus 252 f~~~~~~~~~~-------------~~~~~~------~~~~~~~~~~~ydav~~~~~al~~~~~~~~~~~~~~~~~~c~~~ 312 (384) T 3SAJ_B 252 IMQQWRTSDSR-------------DHTRVD------WKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLAN 312 (384) T ss_dssp HHHHHHHHHHH-------------C------------CCCCHHHHHHHHHHHHHHHHHHHHHHHTCCCCCCCSCCCSCCB T ss_pred HHHHHHccCcc-------------CCCCCC------CCCCcchHHHHHHHHHHHHHHHHHHHHCCCCchhcCCCCCcccC Confidence 33333333221 010000 01234567789999999999999887543210 01122211 Q NP_000836.2 435 ---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 435 ---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) ...++..+.+.|++..|.|.+| ++.||++|++.. .+.+++++ ++.++.||.|+... T Consensus 313 ~~~~~~~~~~l~~~l~~~~f~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~ 372 (384) T 3SAJ_B 313 PAVPWGQGIDIQRALQQVRFEGLTG-NVQFNEKGRRTNYTLHVIEMK----HDGIRKIGYWNEDD 372 (384) T ss_dssp SCCCCTTHHHHHHHHHTCEEEETTE-EEEBCTTSBBCSCCEEEEEEE----TTEEEEEEEEETTT T ss_pred CCCCcccHHHHHHHHhcCCccCCcc-eEEECCCCCeeeeEEEEEEee----eCceEEeEEEcCCC Confidence 0114456778888888999988 899999888753 56666665 35789999998653 No 82 >3N6V_D Glutamate receptor 2; AMPA, assembly, NTD, GluR2, GluA2; 3.2A {Rattus norvegicus} Probab=99.52 E-value=6.9e-19 Score=188.37 Aligned_cols=355 Identities=15% Similarity=0.178 Sum_probs=216.7 Template_Neff=12.200 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI-LDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~-~d~~~~~~~a~~~~~~~~~~l~ 124 (908) ++||+++|.++. ....|+++|++++|+. |.++++.+ .|+.+++.. ..+.+++++ T Consensus 1 i~ig~~~~~~g~----------------~~~~~~~~a~~~in~~-----g~~l~~~~~~~~~~~~~~----~~~~~~~l~ 55 (374) T 3N6V_D 1 IQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFA----VTNAFCSQF 55 (374) T ss_dssp CEEEEEEETTCH----------------HHHHHHHHHHHHHCCS-----SCCCEEEEEEECTTCHHH----HHHHHHHHH T ss_pred CceeeeeCCCCH----------------HHHHHHHHHHHHhhCC-----CceeceeEEecCCCChHH----HHHHHHHHH Confidence 578999988752 4678999999999975 35667665 455444332 222333333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . ++++++||+.++.....++.++...+||+|++..... ..+++++++.|+ .+. T Consensus 56 ~-------------------~~v~~iig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~---~~~ 108 (374) T 3N6V_D 56 S-------------------RGVYAIFGFYDKKSVNAITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPD---LKG 108 (374) T ss_dssp H-------------------HTCSEEEECCCTTTHHHHHHHHHHHTCEEEECSCCCS-----SCCSSEEECSCC---HHH T ss_pred h-------------------cCeeEEEecCChHHHHHHHHHHHhcCCceeeCCCCCC-----CCCCcEEEecCC---HHH Confidence 2 4788999998887777778889999999998764321 246889999887 367 Q NP_000836.2 205 AMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE--PRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 205 ~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~--~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) ++++++.+++|+++++++.++ ++....+.+.+.+++. ++++......+.. .+..++...+++++. .++++|++.+ T Consensus 109 ~~~~~~~~~~~~~v~iv~~~~-~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vv~~~ 185 (374) T 3N6V_D 109 ALLSLIEYYQWDKFAYLYDSD-RGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKERRVILDC 185 (374) T ss_dssp HHHHHHHHTTCCEEEEEECGG-GCSHHHHHHHHHHHHT-TCEEEEEECTTCCSTTHHHHHHTTSTTTTT-TTCCEEEEES T ss_pred HHHHHHHHhCCcEEEEEEeCC-cchhhHHHHHHHHHhc-CCeEEEEEeccCCCCCCccchHHHHHHHcc-cCCcEEEEEC Confidence 778888788999999999655 7777777777777664 3555432221100 112356666777763 5789988887 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAE 361 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 361 (908) ....+..+++++++.|+.. .+.|+..+........ ........+...+... . ...+....|.+ T Consensus 186 ~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~----~~~~~~~~f~~ 249 (374) T 3N6V_D 186 ERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGANVSGFQIV-----------D----YDDSLVSKFIE 249 (374) T ss_dssp CHHHHHHHHHHHHHTTCSSTTCEEEECSSBSSSSCC-GGGTTTSCEEEEEESS-----------C----TTSHHHHHHHH T ss_pred CHHHHHHHHHHHHHcCCccCceEEEEecCCCCcccH-hHhhcCCeeEEEEEEE-----------c----CCChHHHHHHH Confidence 7777888999998888753 3456655321111000 0000011111111100 0 00111122333 Q NP_000836.2 362 FWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG----YIGLCPRM--- 434 (908) Q Consensus 362 ~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~----~~~~~~~~--- 434 (908) .|++.+..... .. ....+..++..+||+++++++|++++....+.. ....|... T Consensus 250 ~~~~~~~~~~~-------------~~------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~c~~~~~~ 310 (374) T 3N6V_D 250 RWSTLEEKEYP-------------GA------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAV 310 (374) T ss_dssp HHTTSCTTTST-------------TC------SSSCCCHHHHHHHHHHHHHHHHHHTTTTTTCCCCC----CCTTCSSCC T ss_pred HHHcCChhhCC-------------CC------CCCccchhHHHHHHHHHHHHHHHHHHHhcccccccCCCCCCccCCCCC Confidence 33322211000 00 001234567789999999999999886432110 00122110 Q NP_000836.2 435 STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 435 ~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) ...++..+.+.|++..|.|.+| ++.|+++|++.. .+.+++++ .+.++.+|.|+... T Consensus 311 ~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~ 367 (374) T 3N6V_D 311 PWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEVD 367 (374) T ss_dssp CCTTHHHHHHHHHTCEEEETTE-EEEBCTTSCBCSCEEEEEEEC----SSCEEEEEEEETTT T ss_pred CccchHHHHHHHhcCccccCCe-eEEECCCCCeeeeEEEEEEee----cCCcEEEEEEeCCC Confidence 0124556778888888999988 899999998875 78888887 24788999998653 No 83 >4GNR_A ABC transporter substrate-binding protein-branched chain; amino acid-binding protein, surface-exposed protein; 1.0A {Streptococcus pneumoniae} Probab=99.52 E-value=7e-19 Score=186.67 Aligned_cols=347 Identities=15% Similarity=0.192 Sum_probs=213.1 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||+++|.++... ..+.....+++.|++++|+.+++ .++++++...|+.+++.. ..+.+ T Consensus 3 ~~~~~~~Ig~~~~~~~~~~----------~~~~~~~~~~~~a~~~~n~~~~~-~~~~~~~~~~d~~~~~~~----~~~~~ 67 (353) T 4GNR_A 3 VEEKTIKIGFNFEESGSLA----------AYGTAEQKGAQLAVDEINAAGGI-DGKQIEVVDKDNKSETAE----AASVT 67 (353) T ss_dssp ---CEEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHHTTCB-TTBEEEEEEEECTTCHHH----HHHHH T ss_pred ccCceEEEEEEecCCCCch----------HHcHHHHHHHHHHHHHHHHCCCC-CCcceEEEEecCCCChHH----HHHHH Confidence 3457899999999876421 35667888999999999987654 357788877777655432 33333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .++++++||+.++.....+...+...++|+|.+....+.+.. ..++++++.++.. T Consensus 68 ~~l~~------------------~~~v~~iig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~ 127 (353) T 4GNR_A 68 TNLVT------------------QSKVSAVVGPATSGATAAAVANATKAGVPLISPSATQDGLTK--GQDYLFIGTFQDS 127 (353) T ss_dssp HHHHH------------------TSCCSEEECCCSHHHHHHHHHHHHHTTCCEEESSCCCTTTTT--TCTTEEECSCCHH T ss_pred HHHHh------------------cCCeeEEECCCChHHHHHHHHHHHHhCCCEEecCCCCCcCcC--CCCceeEecCChH Confidence 33332 147899998877766667777888899999998765544332 2467788888888 Q NP_000836.2 201 YQAQAMVDIVT-ALGWNYVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 201 ~~~~~~~~~l~-~~~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ..++++++++. +++|+++++++.+ +.++....+.+.+... ..+.....+. .+..+....++++++ .+++++ T Consensus 128 ~~~~~~~~~l~~~~~~~~v~i~~~~~~~~~~~~~~~~~~~~~----~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i 200 (353) T 4GNR_A 128 FQGKIISNYVSEKLNAKKVVLYTDNASDYAKGIAKSFRESYK----GEIVADETFV--AGDTDFQAALTKMKG-KDFDAI 200 (353) T ss_dssp HHHHHHHHHHHHTSCCSEEEEEEETTCHHHHHHHHHHHHHCC----SEEEEEEEEC--TTCCCCHHHHHHHHT-SCCSEE T ss_pred HHHHHHHHHHHHHcCCCEEEEEEcCcchHHHHHHHHHHHHcC----CceeeEEEec--CCCCCHHHHHHHhhc-CCCCEE Confidence 88888898885 5789999998855 4555555555554322 2222211121 122345566777763 578888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW 358 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 358 (908) ++......+..+++++++.|+. ..|++.+.+...............+.+...... .. ....+.... T Consensus 201 i~~~~~~~~~~~~~~~~~~g~~--~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------~~--~~~~~~~~~ 266 (353) T 4GNR_A 201 VVPGYYNEAGKIVNQARGMGID--KPIVGGDGFNGEEFVQQATAEKASNIYFISGFS----------TT--VEVSAKAKA 266 (353) T ss_dssp ECCSCHHHHHHHHHHHHHTTCC--SCEEECGGGCSHHHHHHHCTTTCCSEEEEESCC----------SS--SSCCHHHHH T ss_pred EEcCCHHHHHHHHHHHHHCCCC--CCEEeccccccHHHHHHhchhhhcCEEEEeccc----------CC--cccCHHHHH Confidence 7776666778888888888773 456665543321110000001111211111000 00 000011112 Q NP_000836.2 359 FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTID 438 (908) Q Consensus 359 ~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~ 438 (908) |.+.+.+.++ ..++.++..+||+++++++++++... T Consensus 267 f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~----------------- 302 (353) T 4GNR_A 267 FLDAYRAKYN---------------------------EEPSTFAALAYDSVHLVANAAKGAKN----------------- 302 (353) T ss_dssp HHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHTTCSS----------------- T ss_pred HHHHHHHHHC---------------------------CCCChHHHHHHHHHHHHHHHHhcCCC----------------- Confidence 2222222111 11235678899999999999987531 Q NP_000836.2 439 GKELLGYIRA-VNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 439 ~~~l~~~l~~-~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) ++.+.+.|++ ..|.|.+| ++.|+++|++...+.+.+++ ++.++.+|.|+ T Consensus 303 ~~~~~~~l~~~~~~~g~~G-~~~f~~~~~~~~~~~v~~~~----~~~~~~~~~~~ 352 (353) T 4GNR_A 303 SGEIKDNLAKTKDFEGVTG-QTSFDADHNTVKTAYMMTMN----NGKVEAAEVVK 352 (353) T ss_dssp HHHHHHHHHTCCCEEETTE-EECCCTTSCCCCCEEEEEEE----TTEEEEEEEEC T ss_pred hHHHHHHHhcCCCCCCCcc-eeEEcCCCCccceEEEEEEE----CCEEEEeeeeC Confidence 2346677766 47889988 89999988887778888776 35788888885 No 84 >3N0X_A Possible substrate binding protein of; Receptor family ligand binding region; HET: GOL; 1.5A {Rhodopseudomonas palustris} Probab=99.52 E-value=7.4e-19 Score=188.33 Aligned_cols=348 Identities=14% Similarity=0.174 Sum_probs=214.4 Template_Neff=11.600 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.++... ..+.....|++.|++++|+.++.++|.++++.+.|+++++..+ .+.+++ T Consensus 2 ~~~i~Ig~~~~~~g~~~----------~~~~~~~~g~~~a~~~~n~~g~~~~g~~i~~~~~d~~~~~~~~----~~~~~~ 67 (374) T 3N0X_A 2 ADDLKIALIYGKTGPLE----------AYAKQTETGLMMGLEYATKGTMTLDGRKIVVITKDDQSKPDLS----KAALAE 67 (374) T ss_dssp --CEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHTTTCCEETTEEEEEEEEECTTCHHHH----HHHHHH T ss_pred CCceEEEEEeCCCCCch----------HHHHHHHHHHHHHHHHhhcCCCccCCeEEEEEEecCCCChHHH----HHHHHH Confidence 46799999999887431 3566788999999999998554355788999988887765433 333344 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++.+ +++++++|+.++.....++..+...++|++...+.++.+.+...+++++++.++.... T Consensus 68 l~~~------------------~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 129 (374) T 3N0X_A 68 AYQD------------------DGADIAIGTSSSAAALADLPVAEENKKILIVEPAVADQITGEKWNRYIFRTGRNSSQD 129 (374) T ss_dssp HHHT------------------SCCSEEEECSSHHHHHHHHHHHHHHTCCEEECSCCCGGGGTTTCCTTEEECSCCHHHH T ss_pred HHhh------------------cCCCEEEecCCcHHHHhHHHHHHHcCCEEEeCCCCchHHhCCCCCccEEEccCCchhH Confidence 3321 5788999988777777788888889999998776555443322467889999988888 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET----PNARAV 278 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~----~~~~vi 278 (908) +.++++++.+ .|++|++++.++.++....+.+++.+++. ++++.....+. .+..++...+++++.. .++++| T Consensus 130 ~~~~~~~~~~-~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~i~~~~~~~~~~~~v 205 (374) T 3N0X_A 130 AISNAVAIGK-QGVTIATLAQDYAFGRDGVAAFKEALAKT-GATLATEEYVP--TTTTDFTAVGQRLFDALKDKPGKKII 205 (374) T ss_dssp HHHHHHHHCC-TTEEEEEEEESSHHHHHHHHHHHHHHTTT-TCEEEEEEEEC--TTCCCCHHHHHHHHHHHTTCSSEEEE T ss_pred HHHHHHHHHh-cCCEEEEEecCcHHHHHHHHHHHHHHHHc-CCeeceeeecC--CCCCChHHHHHHHHHHhcCCCCCCeE Confidence 8888887765 67899999977778888888888888765 45654433332 2233455566666521 145666 Q NP_000836.2 279 IMFA-NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 279 v~~~-~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) ++.. .......++++++..++. ..|+..+.+.... ... ....+........ .. ....+... T Consensus 206 ~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~---~~~-~~~~~~~~~~~~~---------~~---~~~~~~~~ 267 (374) T 3N0X_A 206 WVIWAGGGDPLTKLQDMDPKRYG--IELSTGGNILPAL---AAY-KRLPGMEGATYYY---------YD---IPKNPINE 267 (374) T ss_dssp EECCCSSSCHHHHHHHTCGGGGT--EEEEECCCCTTGG---GGG-GGSTTCEEEESCC---------TT---SCCSHHHH T ss_pred EEEEecCCcHHHHHHhccccccC--ceeccccchHHHH---HHH-hhCCCceeeeecc---------cc---CCCChhhH Confidence 5533 344455666666665542 2344332221100 000 0011111100000 00 00011122 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTI 437 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~ 437 (908) .|.+.+++.++ ..++.++..+|||+++++.|++++.. . T Consensus 268 ~f~~~~~~~~~---------------------------~~p~~~~~~~yda~~~~~~al~~~~~---------------~ 305 (374) T 3N0X_A 268 WLVTEHQKRFN---------------------------APPDFFTAGGFSAAMAVVTAVQKAKS---------------T 305 (374) T ss_dssp HHHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHTS---------------C T ss_pred HHHHHHHHHHC---------------------------CCCChhHHHHHHHHHHHHHHHHHcCC---------------C Confidence 23332322221 11235678899999999999988642 1 Q NP_000836.2 438 DGKELLGYIRAVNFNGSAGTPVTFNE-NGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 438 ~~~~l~~~l~~~~f~G~~G~~v~Fd~-~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ++..+.++|++..|+|.+| ++.|++ ++++...+.+++++.. + +|.|+.. T Consensus 306 ~~~~i~~~l~~~~~~g~~G-~i~f~~~~~~~~~~~~i~~~~~~---~----~~~w~~~ 355 (374) T 3N0X_A 306 DTEKLIAAMEGMEFDTPKG-KMVFRKEDHQALQSMYHFKVKVD---P----AVAWAVL 355 (374) T ss_dssp CHHHHHHHHTTCEEEETTE-EEEECTTTCBEECCEEEEEEECC---T----TSSSCEE T ss_pred CHHHHHHHHcCCceecCCe-eEEeCCCCCeeeeeeEEEEEcCC---h----hhhcccc Confidence 3456778888888999888 899987 5555567777776621 1 5677654 No 85 >6KSP_B Glutamate receptor ionotropic, delta-1; complex, membrane protein; 8.1A {Rattus norvegicus} Probab=99.52 E-value=7.5e-19 Score=210.74 Aligned_cols=372 Identities=15% Similarity=0.185 Sum_probs=225.3 Template_Neff=11.500 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILD-TCSRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d-~~~~~~~a~~~~~~~~~~ 122 (908) ++++||+++|.++. ....|+++|++++|+++++++|+++++++.| +++++..+ .+.+++ T Consensus 2 ~~i~Ig~l~p~sg~----------------~~~~g~~~a~~~in~~~g~~~~~~i~~~~~d~~~~~~~~~----~~~~~~ 61 (856) T 6KSP_B 2 SIIHIGAIFEENAA----------------KDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQA----VQEACD 61 (856) T ss_dssp CCCBCCEEECSCCH----------------HHHHHHHHHHHHHHSSCSSSTTCCCBCCEEECCSSCCHHH----HHHHHH T ss_pred ceeeeeeeeccccc----------------CchHHHHHHHHHHhcCcccccccceeEEeEeccCCCHHHH----HHHHHH Confidence 57999999998752 5678999999999998877767899999888 55554332 233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS-- 200 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~-- 200 (908) ++. ++++++||+.++..+.+++..+...++|+|++ +..+.+.. .++++++..+++. T Consensus 62 l~~-------------------~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~-~~~~~~~~--~~~~~~~~~~~~~~~ 119 (856) T 6KSP_B 62 LMT-------------------QGILALVTSTGCASANALQSLTDAMHIPHLFV-QRNPGGSP--RTACHLNPSPDGEAY 119 (856) T ss_dssp HTT-------------------TCCSCCCCBCCSTTSHHHHHHHHTTTCCEEEC-CCCTTSCC--CCCCCCCSCCTTTCC T ss_pred Hhh-------------------cCeeEEecCCCchhHHHHHHHHHhcCCCEEEe-ecCCCCCC--CcccccccCCCCCce Confidence 332 57899999988887778888899999999998 44443332 3455666655554 Q NP_000836.2 201 --------YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPR---E---PRPGEFEKII 266 (908) Q Consensus 201 --------~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~---~---~~~~~~~~~~ 266 (908) .++.++++++++++|+++++++ +++++....+.+.+.+++. ++++.....++. + ....+....+ T Consensus 120 ~~~~~p~~~~~~~l~~~~~~~~~~~v~il~-~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~~~l 197 (856) T 6KSP_B 120 TLASRPPVRLNDVMLRLVTELRWQKFVMFY-DSEYDIRGLQSFLDQASRL-GLDVSLQKVDKNISHVFTSLFTTMKTEEL 197 (856) T ss_dssp EEECSCCCCHHHHHHHHHHHHTCCSCEEEE-CTTCCGGGGTTHHHHHHHT-TCCCEEEECCSCHHHHHHHHHHHCCHHHH T ss_pred eeecCCCccHHHHHHHHHHHcCCcEEEEEE-eCCchHHHHHHHHHHHHhh-CCeEEEEEccCChhHhcHHHHhhhcHHHH Confidence 7788888888888999999999 6667777777777777664 355433222110 0 0122334556 Q NP_000836.2 267 KRLLETPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 267 ~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) +++++ . .+.+++.+....+..+++++++.|+.. .+.|+..+.+...............+....... T Consensus 198 ~~~~~-~-~~~vv~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------- 264 (856) T 6KSP_B 198 NRYRD-T-LRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQI----------- 264 (856) T ss_dssp HHHHH-H-HTEEEECSCHHHHHHHHHHHHHTTCCCTTCEEEECCSCCCHHHHHHHHHHCSSBCEEEECC----------- T ss_pred Hhchh-h-cceEEEEcChHHHHHHHHHHHHcCCCCCCceEEEEcCCCCChhHHHHHhhhcccceEEehh----------- Confidence 66653 3 344444455667888899998888753 356666543322111000000011111111000 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) . ...+....|.+.+++.+.+. |..... ....+..++..+|||++++++|++++....+. T Consensus 265 ~----~~~~~~~~f~~~~~~~~~~~-------------~~~~~~----~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~ 323 (856) T 6KSP_B 265 F----PSAKDNQKCMRNNHRISSLL-------------CDPQEG----YLQMLQISNLYLYDSVLMLANAFHRKLEDRKW 323 (856) T ss_dssp C----CCSCCSSTTBCSSCBCCSST-------------TTTCTT----TSTTCCHHHHHHHHHHHHHHHHHHHHHTTTCC T ss_pred c----CCcchhHHHHhhcccccccc-------------cCCCcc----ccccccHHHHHHHHHHHHHHHHHHHHHHcCCc Confidence 0 00111222333333332210 000000 00123456788999999999999987643211 Q NP_000836.2 426 G--YIGLCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITN-KSTEYKVIGHWTNQ 494 (908) Q Consensus 426 ~--~~~~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~-~~~~~~~Vg~~~~~ 494 (908) . ....|... ...++..+.++|++..|.|.+| ++.||++|++. ..+.+++++..+ ....+..||.|... T Consensus 324 ~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~g~~G-~v~f~~~g~~~~~~~~i~~~~~~~~~~~~~~~v~~~~~~ 398 (856) T 6KSP_B 324 HSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTG-VMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSE 398 (856) T ss_dssp CCCCSCCSSSSCCCCCSTTHHHHHHHHTCCCCSSSS-CCCCCTTCBCCCCEEEEEECCCBTTTBCCCCCCEEEETT T ss_pred ccccccccccCCCCCccCchhHHHHHHhCceeeeee-eEEecCCCCCceEEEEEEeeccCCcCCcceEEEEEEeCC Confidence 0 01112110 1124567888888889999998 89999999875 578888887431 12367889999864 No 86 >3N6V_B Glutamate receptor 2; AMPA, assembly, NTD, GluR2, GluA2; 3.2A {Rattus norvegicus} Probab=99.52 E-value=8.3e-19 Score=187.76 Aligned_cols=355 Identities=15% Similarity=0.178 Sum_probs=216.6 Template_Neff=12.200 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI-LDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~-~d~~~~~~~a~~~~~~~~~~l~ 124 (908) ++||+++|.++. ....|+++|++++|+. |.++++.+ .|+.+++.. ..+.+++++ T Consensus 1 i~ig~~~~~~g~----------------~~~~~~~~a~~~in~~-----g~~l~~~~~~~~~~~~~~----~~~~~~~l~ 55 (374) T 3N6V_B 1 IQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFA----VTNAFCSQF 55 (374) T ss_pred CeEEEEccCCCH----------------HHHHHHHHHHHHHHHC-----CCEEEEEEEeCCCCCHHH----HHHHHHHHH Confidence 578999988752 4678999999999975 35667665 455444332 222333333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . ++++++||+.++.....++.++...+||+|++..... ..+++++++.|+ .+. T Consensus 56 ~-------------------~~v~~iig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~---~~~ 108 (374) T 3N6V_B 56 S-------------------RGVYAIFGFYDKKSVNAITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPD---LKG 108 (374) T ss_pred h-------------------cCCCEEECCCChHHHHHHHHHHHhhCCCEECCCcCCC-----ccCCceeecCHH---HHH Confidence 2 4788999998887777778888999999998764321 246889999887 367 Q NP_000836.2 205 AMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE--PRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 205 ~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~--~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) ++++++.+++|++++++++++ ++....+.+.+.+++. ++++......+.. .+..++...+++++. .++++|++.+ T Consensus 109 ~~~~~~~~~~~~~v~iv~~~~-~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vv~~~ 185 (374) T 3N6V_B 109 ALLSLIEYYQWDKFAYLYDSD-RGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKERRVILDC 185 (374) T ss_pred HHHHHHHHhCCCeEEEEEeCc-hhHHHHHHHHHHHHHC-CCEEEEEEeeCCCCCCCCCCHHHHHHHHHH-cCCCEEEEeC Confidence 778888788999999999655 7777777777777664 3555432221100 122356666777763 5789988887 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAE 361 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 361 (908) ....+..+++++++.|+.. .+.|+..+........ ........+...+... . ...+....|.+ T Consensus 186 ~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~----~~~~~~~~f~~ 249 (374) T 3N6V_B 186 ERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGANVSGFQIV-----------D----YDDSLVSKFIE 249 (374) T ss_pred CHHHHHHHHHHHHHcCCCCCCcEEEEecCCCCCCch-HHhhccccceeeeeec-----------C----CCCHHHHHHHH Confidence 7777888999998888753 3456655321111000 0000011111111100 0 00111122333 Q NP_000836.2 362 FWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG----YIGLCPRM--- 434 (908) Q Consensus 362 ~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~----~~~~~~~~--- 434 (908) .|++.+..... .. ....+..++..+||+++++++|++++....+.. ....|... T Consensus 250 ~~~~~~~~~~~-------------~~------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~c~~~~~~ 310 (374) T 3N6V_B 250 RWSTLEEKEYP-------------GA------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAV 310 (374) T ss_pred HHHHHhCCCCC-------------CC------CCCCCccHHHHHHHHHHHHHHHHHHHhhcCCcccCCCCCCccCCCCCC Confidence 33322211000 00 001234567789999999999999886432110 00122110 Q NP_000836.2 435 STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 435 ~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) ...++..+.+.|++..|.|.+| ++.|+++|++.. .+.+++++ .+.++.+|.|.... T Consensus 311 ~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~ 367 (374) T 3N6V_B 311 PWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEVD 367 (374) T ss_pred CCCCHHHHHHHHHcCcccCCCc-ceEeCCCCCcCCCeEEEEEEe----CCceEEeEEEeCCC Confidence 0124556778888889999988 899999998875 78888887 24788999998653 No 87 >1Z17_A Leu/Ile/Val-binding protein; periplasmic binding proteins, alpha-beta fold; 1.96A {Escherichia coli} Probab=99.52 E-value=8.4e-19 Score=185.21 Aligned_cols=333 Identities=20% Similarity=0.234 Sum_probs=211.1 Template_Neff=12.300 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|.++... ..+.....+++.|++++|+.+++. |+++++.+.|+.+++. ...+.+++++ T Consensus 2 ~~~Ig~~~~~~~~~~----------~~~~~~~~~~~~a~~~~n~~~~~~-g~~i~~~~~d~~~~~~----~~~~~~~~l~ 66 (344) T 1Z17_A 2 DIKVAVVGAMSGPVA----------QYGDQEFTGAEQAVADINAKGGIK-GNKLQIVKYDDACDPK----QAVAVANKVV 66 (344) T ss_dssp CEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHHHHTTTBT-TBCEEEEEEECTTCHH----HHHHHHHHHH T ss_pred CeEEEEEecCCCchH----------HhhHHHHHHHHHHHHHHHHCCCcC-CceEEEEEEcCCCCHH----HHHHHHHHHH Confidence 689999999875321 245678899999999999876543 6778888777665532 2223333333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . ++++++|++.++.....+...+...++|+|.+....+.+... .+++++++.+++...+. T Consensus 67 ~-------------------~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~ 126 (344) T 1Z17_A 67 N-------------------DGIKYVIGHLCSSSTQPASDIYEDEGILMITPAATAPELTAR-GYQLILRTTGLDSDQGP 126 (344) T ss_dssp H-------------------TTCCEEEECCSHHHHHHHHHHHHHHTCEEEESSCCCGGGGSS-CCSSEEESSCCHHHHHH T ss_pred h-------------------cCCCEEEcCCCCcchHHHHHHHHHHCCeEEecCCCCHHHHhc-CCCeEEEecCCcccchH Confidence 2 478899988766655566677788899999987655443221 24677888888888888 Q NP_000836.2 205 AMVDIVT-ALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFAN 283 (908) Q Consensus 205 ~~~~~l~-~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~~ 283 (908) .+++++. +.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .+++++++... T Consensus 127 ~~~~~l~~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~~~~ 202 (344) T 1Z17_A 127 TAAKYILEKVKPQRIAIVHDKQQYGEGLARAVQDGLKKG-NANVVFFDGIT--AGEKDFSTLVARLKK-ENIDFVYYGGY 202 (344) T ss_dssp HHHHHCCCCCCCSSEEEEECSSHHHHHHHHHHHHHHHHT-TCCEEEEEECC--TTCCCCHHHHHHHHH-TTCCEEEEESC T ss_pred HHHHHHHHHcCCCEEEEEEcCCchhHHHHHHHHHHHHhC-CCEEeEEeccC--CCCCChHHHHHHHHH-CCCCEEEEecC Confidence 8888884 4589999999976667777788888887765 35543322222 122345556666653 47888877765 Q NP_000836.2 284 EDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFW 363 (908) Q Consensus 284 ~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 363 (908) +..+..+++++++.|+ ++.|++.+.+...... ........+.+...+.. ....+....|.+.+ T Consensus 203 ~~~~~~~~~~~~~~g~--~~~~i~~~~~~~~~~~-~~~~~~~~g~~~~~~~~--------------~~~~~~~~~f~~~~ 265 (344) T 1Z17_A 203 HPEMGQILRQARAAGL--KTQFMGPEGVANVSLS-NIAGESAEGLLVTKPKN--------------YDQVPANKPIVDAI 265 (344) T ss_dssp HHHHHHHHHHHHHTTC--CCEEEECGGGCSHHHH-HHHGGGGTTCEEEECCC--------------GGGSGGGHHHHHHH T ss_pred chHHHHHHHHHHHcCC--CcEEEcCCcccCHHHH-HHhhhhcCCeEEEcCCC--------------CCCCcchHHHHHHH Confidence 6667788899888887 3567766543322110 00111122322211100 00001111222222 Q NP_000836.2 364 EENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELL 443 (908) Q Consensus 364 ~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~l~ 443 (908) ++.++ ..++.++..+|||++++++++++.. ++..+. T Consensus 266 ~~~~~---------------------------~~~~~~~~~~yda~~~~~~a~~~~~-----------------~~~~l~ 301 (344) T 1Z17_A 266 KAKKQ---------------------------DPSGAFVWTTYAALQSLQAGLNQSD-----------------DPAEIA 301 (344) T ss_dssp HTTTC---------------------------CCCSHHHHHHHHHHHHHHHHHTTCS-----------------CHHHHH T ss_pred HHHHC---------------------------CCCChHHHHHHHHHHHHHHHHhcCC-----------------CHHHHH Confidence 22111 1123457789999999999987631 234577 Q NP_000836.2 444 GYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQI 478 (908) Q Consensus 444 ~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~ 478 (908) ++|++..|.|.+| ++.|+++|++. ..+.+.+++. T Consensus 302 ~~l~~~~~~g~~G-~i~f~~~g~~~~~~~~i~~~~~ 336 (344) T 1Z17_A 302 KYLKANSVDTVMG-PLTWDEKGDLKGFEFGVFDWHA 336 (344) T ss_dssp HHHHHSCEEETTE-EECBCTTSCBTTCCCEEEEECT T ss_pred HHHHhCCCCcCce-eeEeCCCCCcCcceEEEEEEec Confidence 7788888999998 89999989876 5777887773 No 88 >4RU0_B Putative branched-chain amino acid ABC; ABC transporter permease, Structural Genomics; HET: MSE, GOL, P3G; 2.442A {Pseudomonas protegens Pf-5} Probab=99.51 E-value=1e-18 Score=192.27 Aligned_cols=370 Identities=12% Similarity=0.111 Sum_probs=225.6 Template_Neff=11.600 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINK-DPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~-~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) ....++++||++.|.++... ..+.....|++.|++++|+ .+++. |+++++.+.|+++++.. ..+ T Consensus 28 ~~~~~~~~ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~~g~~~-g~~v~~~~~d~~~~~~~----~~~ 92 (447) T 4RU0_B 28 QAGPDQQFFPLATYRVGAYA----------SSGVQVWAGMIDYLNYINQVEGGIN-GVKLVWQECETEWTAEK----GIE 92 (447) T ss_dssp --CTTSEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHHTTCSBT-TBCEEEEEEECTTCHHH----HHH T ss_pred hcCCCceEEEEeeccCCCcc----------ccchhHHHHHHHHHHHHHHhcCCcC-CeEeEEEEEcCCCCHHH----HHH Confidence 34567899999999875421 2566788999999999997 55443 67788887777655332 333 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++++.+ ..+.+++++++.++.....+...+...++|+|.+.+..+.+.+....++++++.++ T Consensus 93 ~~~~l~~~----------------~~~~~~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 156 (447) T 4RU0_B 93 CYERFKNG----------------LDGAPVAVYQPNGAPAAYALSERAEVDKIPLITLGYGRTEATDGTVFPYNFPVMLT 156 (447) T ss_dssp HHHHHTTC----------------BTTBCBSCBCCCSHHHHHHHHHHHHHTTCCEECTTCSCGGGGCTTTCTTEECCSCC T ss_pred HHHHHHhc----------------CCCCCEEEEcCCCcHHHHHHHHHHHHcCCCEEEcCCCchhhcCCCCCCccccccCC Confidence 34443320 00367788888777666677778888999999987765543321235678899999 Q NP_000836.2 199 DSYQAQAMVDIVTA-------LGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 199 ~~~~~~~~~~~l~~-------~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) +...++.+++++.+ .+|++|++++.++.++..+.+.+++.+++. ++++... .+. ....+....+++++. T Consensus 157 ~~~~~~~~~~~~~~~~~~~~~~~~~~i~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~-~~~--~~~~~~~~~~~~~~~ 232 (447) T 4RU0_B 157 FYSEASTLVNYIAQREGGFDRLKGKKIATLYHDSAYGRETLGPLKLLAEKY-GFENIQI-PVA--DPGNEQSAQWRQIRQ 232 (447) T ss_dssp HHHHHHHHHHHHHHHHTSGGGGTTCEEEEEEESSHHHHTTHHHHHHHHHHH-CCEEEEE-EEC--TTCCCCHHHHHHHHH T ss_pred hHHHHHHHHHHHHHhcCCccccCCCEEEEEecCChHhHhcHHHHHHHHHHh-CCEEEEE-EeC--CCCCchHHHHHHHHH Confidence 88888899998865 689999999966667777888888888775 4555431 121 122345566666663 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLA 351 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~ 351 (908) .++|++++...+..+..+++++++.|+.. .++..+.|...............+.+...... .. . T Consensus 233 -~~~~~i~~~~~~~~~~~~~~~~~~~g~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------~~---~ 296 (447) T 4RU0_B 233 -QNPDWVFLRTWGVSTPVAVKTAARFGFPV--DHIIGDIWASSSEDVLPAGAAAKGYLALTPYP----------AG---S 296 (447) T ss_dssp -HCCSEEEEECCTTHHHHHHHHHHHTTCCG--GGEEECGGGCSGGGTGGGGGGGTTCEEEESSC----------CC---S T ss_pred -hCCCEEEEEcCCccHHHHHHHHHHcCCCC--cEEEeeccCCCchhhHhhHHhhCCeEEeecCC----------CC---C Confidence 57888887765666778889988888753 23333323221100000111122222211100 00 0 Q NP_000836.2 352 NNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLC 431 (908) Q Consensus 352 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~ 431 (908) ..+....|.+.+++.+...+.. ....++.++..+|||+++++++++++...... T Consensus 297 ~~~~~~~f~~~~~~~~~~~~~~--------------------~~~~~~~~~~~~yda~~~~~~al~~~~~~~g~------ 350 (447) T 4RU0_B 297 DFEIHKRLKQYILDTGKSDLKD--------------------LKNFGSVYYNSGLVNAAVAVEAIRTAQGKFGK------ 350 (447) T ss_dssp CSTTHHHHCCCCCTTTCCSCSC--------------------GGGTTSHHHHHHHHHHHHHHHHHHHHHHHHCS------ T ss_pred CCHHHHHHHHHHHHhCCCcccc--------------------ccccCChhHHHHHHHHHHHHHHHHHHHHhcCC------ Confidence 0011112222222211100000 00112456788999999999999987532100 Q NP_000836.2 432 PRMSTIDGKELLGYIRAVNF----------NGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 432 ~~~~~~~~~~l~~~l~~~~f----------~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ...++..+.+.|++..+ .|.+| ++.|+++|++. ..+.+++++ ++.++.++.|... T Consensus 351 ---~~~~~~~l~~~l~~~~~~~~~~~~~~~~G~~G-~i~f~~~~~~~~~~~~i~~~~----~g~~~~v~~~~~~ 416 (447) T 4RU0_B 351 ---RPLNGEEGRWGLEHLNIDDARLKDMGYLGLMQ-NLKLSCRDHEGGGAARVQQWD----GANWTLISEWIAA 416 (447) T ss_dssp ---SCCCHHHHHHHHHTCEECHHHHHHHTCTTTSC-CEECCSSCSCCCCEEEEEEEC----SSCEEECCCCEEC T ss_pred ---CCCChHHHHHHHHhccCCchHHhccCcccccc-CeeecCCCCcccceEEEEEEe----CCeEEEcceeEec Confidence 01245567777777666 67888 89999888764 467788886 3578899988754 No 89 >5EWM_D NMDA glutamate receptor subunit, Glutamate; Glutamate receptor, allosteric modulator, GluN2B; HET: MAN, 5SM, NAG, BMA; 2.76A {Xenopus laevis} Probab=99.51 E-value=1e-18 Score=186.31 Aligned_cols=349 Identities=15% Similarity=0.211 Sum_probs=214.9 Template_Neff=11.900 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||+++|.++ ...|+++|++++|+.++.. +.++++... ++.++.. ..+.+.+ T Consensus 2 ~~~i~Ig~~~~~~~------------------~~~~~~~a~~~in~~~~~~-~~~i~l~~~-~~~~~~~----~~~~~~~ 57 (364) T 5EWM_D 2 PPSIGIAVILVGTS------------------DEVAIKDAHEKDDFHHLSV-VPRVELVAM-NETDPKS----IITRICD 57 (364) T ss_dssp CCEEEEEEEEESSC------------------CHHHHHC------CCCSSS-EEEEEEEEE-CCCSHHH----HHHHHHH T ss_pred CCeeeEEEEEeCCC------------------chHHHHHHHHhcCCCcCcc-CCceEEEee-CCCCHHH----HHHHHHH Confidence 46789999998652 4578999999999875432 455666655 3444322 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVI--GAAASS-VSIMVANILRLFKIPQISYASTAP-ELSDNTRYDFFSRVVPP 198 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vI--g~~~s~-~~~~va~~~~~~~iP~Is~~~~~~-~l~~~~~~~~~~~~~~~ 198 (908) ++. .+++++++ |+.++. .+..+..++...++|+|++.+..+ .+.+...+++++++.|+ T Consensus 58 l~~------------------~~~v~~vi~~g~~~s~~~~~~~~~~~~~~~iP~i~~~~~~~~~~~~~~~~~~~~~~~~~ 119 (364) T 5EWM_D 58 LMS------------------DRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPS 119 (364) T ss_dssp HHH------------------HSCEEEEEEECSSCCTHHHHHHHHHHHHHTCCEEEEEGGGSSCCCSCCTTCCEEESSCC T ss_pred HHh------------------cCCceEEEEcCCCChHHHHHHHHHHHHhhCCCEEeecCCCcccccCcccCcceeecCCC Confidence 332 14789999 887775 466777788889999999876542 33333357899999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPR-PGEFEKIIKRLLETPNARA 277 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~-~~~~~~~~~~l~~~~~~~v 277 (908) +...++++++++++++|+++++++.++.++....+.+++.+++. ++++.....+..... ..++...+++++. .++++ T Consensus 120 ~~~~~~~~~~~~~~~~~~~i~il~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~i~~-~~~~~ 197 (364) T 5EWM_D 120 IEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENS-FVGWELEEVLLLDMSLDDGDSKIQNQLKK-LQSPI 197 (364) T ss_dssp HHHHHHHHHHHHHHHTCCEEEEEEESSTTHHHHHHHHHHHHHSC-CSSCEEEEEEEECCSSCCTTCHHHHHHTT-CCCSE T ss_pred HHHHHHHHHHHHHHcCCeEEEEEEEcCCchHHHHHHHHHHHHhh-CCcEEEEEEEecCCCCCcchHHHHHHHHh-CCCCE Confidence 98889999999988899999999987777777778888877765 355443222210011 2345566666753 57888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) |++.+....+..+++++++.|+.. .+.|+..+.+...... .......+.+.+ . T Consensus 198 v~~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~~~---------------------~--- 251 (364) T 5EWM_D 198 ILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDT--VPAEFPTGLISV---------------------S--- 251 (364) T ss_dssp EEEESCHHHHHHHHHHHHHTTCSSTTCEEEECHHHHCSTTC--CCTTSCTTCEEE---------------------E--- T ss_pred EEEeCCHHHHHHHHHHHHHcCCCCCcEEEEeecCCCCCCCC--CCccCCCcEEEE---------------------e--- Confidence 888877777788899998888753 3566665422111000 000000010000 0 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG--YIGLCPRM 434 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~--~~~~~~~~ 434 (908) . ..+ ...++..+|||++++++|++++....+.. ....|... T Consensus 252 --~-----~~~------------------------------~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~c~~~ 294 (364) T 5EWM_D 252 --Y-----DEW------------------------------DYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNT 294 (364) T ss_dssp --E-----CTT------------------------------TSCHHHHHHHHHHHHHHHHHHHHHHHSCCCCCCSCSSCS T ss_pred --e-----cCc------------------------------ccCccHHHHHHHHHHHHHHHHHHhhCCCCCCCCCccccC Confidence 0 000 01235679999999999999886532110 01223211 Q NP_000836.2 435 ---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 ---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ...++..+.++|++..|.| | .+.|+++|++. ..+.|++++. +..++.||.|+... +....+.|+ T Consensus 295 ~~~~~~~~~~l~~~l~~~~~~g--g-~~~f~~~g~~~~~~~~i~~~~~---~~~~~~vg~w~~~~-l~~~~~~w~ 362 (364) T 5EWM_D 295 HEKRIYQSNMLNRYLINVTFEG--R-DLSFSEDGYQMHPKLVIILLNK---ERKWERVGKWKDKS-LQMKYYVWP 362 (364) T ss_dssp GGGGGGCCCTTHHHHTSCCCC-----CCCBCTTSBBSSCCEEEEEECT---TSCEEEEEEECSSC-EEESCSSCC T ss_pred ccceeehHHHHHHHheeeEecC--e-eeeeCCCCccccceEEEEEecC---CccEEEeEEEECCe-eeeeceecC Confidence 1124566778888888988 7 89999999886 5788888873 24688999998762 322345563 No 90 >4MLC_A Extracellular ligand-binding receptor; Structural Genomics, PSI-Biology, Midwest Center; HET: MSE, SO4; 2.705A {Desulfitobacterium hafniense} Probab=99.51 E-value=1.1e-18 Score=185.42 Aligned_cols=346 Identities=20% Similarity=0.252 Sum_probs=211.0 Template_Neff=12.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.+. .+.....+++.|++++|+.+++ .|.++++.+.|+.+++.. ..+. T Consensus 5 ~~~~~~~~Ig~~~~~~~--------------~~~~~~~~~~~a~~~~n~~~~~-~g~~~~~~~~d~~~~~~~----~~~~ 65 (356) T 4MLC_A 5 VNPSEEIFIGVAWPFAS--------------LDDLFAEGLELAVQEINEQGGV-QGRKLSLVKADDEAELEK----GLAI 65 (356) T ss_dssp ----CEEEEEEEECCTT--------------CCSSHHHHHHHHHHHHHTTTTB-TTBEEEEEEEECTTCHHH----HHHH T ss_pred cCCCCcEEEEEEcCCCC--------------ccHHHHHHHHHHHHHHHHcCCc-CCeeEEEEEEcCcccHHH----HHHH Confidence 34567899999999642 3456788999999999987654 367788888887665432 2333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++++. .++++++|++.++.....+...+...++|+|++....+.+... .+++++++.+++ T Consensus 66 ~~~l~~------------------~~~v~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~ 126 (356) T 4MLC_A 66 AQAFAD------------------NAGIQAVIGHRNSFISIPAASIYDQAGLVMLSPASTSPDLTDH-GYIHVFRNIPSD 126 (356) T ss_dssp HHHHHT------------------CTTEEEEECCSSHHHHHHHHHHHHHHTCEEEESSCCCGGGGSS-CCSSEEESSCCH T ss_pred HHHHHH------------------cCCccEEEcCCCchhhHHHHHHHHHhCCeEEEcCcCCcccccC-CCCCeEECCCCH Confidence 333332 1478999988776666666777888999999887655443221 356788899988 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) ...++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++++++ T Consensus 127 ~~~~~~~~~~l~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~v~ 202 (356) T 4MLC_A 127 QEIARQLAIYLAEQGHERMVIYYTDDSYGNGLANAFEDYARAQ-GITIVDRFNYY--GNLKDLERLYDKWQA-FGMDGIF 202 (356) T ss_dssp HHHHHHHHHHHHHTTCCEEEEEECSSHHHHHHHHHHHHHHHHT-TCEEEEEESCC--CSHHHHHHHHHHHHH-HTCCEEE T ss_pred HHHHHHHHHHHHHcCCCEEEEEEcCCcchhHHHHHHHHHHHHC-CCeEeEEEecC--CCCccHHHHHHHHHH-cCCCEEE Confidence 8888999999888899999999966667777888888888775 45554322221 122345556666653 4778887 Q NP_000836.2 280 MFANE-DDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAP--VYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 280 ~~~~~-~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~--~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) +.... ..+..+++++++.|+. .+|++.+.|...... .........+.+..... ... ...+.. T Consensus 203 ~~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------~~~---~~~~~~ 267 (356) T 4MLC_A 203 IAKTATGGGTEFLVDAKSVGIE--VPLIAGNSWDALSLTEDIENIGMTAEGLLVGSFF----------NPQ---RPDSRT 267 (356) T ss_dssp EESCCCCCCHHHHHHHHHHTCC--SCEEECGGGCC----------CGGGTTCEEEEEC----------CTT---CSSHHH T ss_pred EEecCccchHHHHHHHHHcCCC--CCEEecCccchhchHHHHHHhhhhhcCeEEEecC----------CCC---CCChhH Confidence 76543 3567788888887773 456655544321100 00000111121111100 000 000111 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMST 436 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~ 436 (908) ..|.+.+++.++ ..++.++..+|||++++++|+++... T Consensus 268 ~~f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~--------------- 305 (356) T 4MLC_A 268 QDFVEAFRREYG---------------------------QPPTSYAAAGYDAVILLAEALEKSDL--------------- 305 (356) T ss_dssp HHHHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHTTSCS--------------- T ss_pred HHHHHHHHHHHC---------------------------CCCCHHHHHHHHHHHHHHHHHHhCCC--------------- Confidence 122222222111 11235677899999999999987642 Q NP_000836.2 437 IDGKELLGYIRA-VNFNGSAGTPVTFNENGDAPGRYD-IFQYQITNKSTEYKVIG 489 (908) Q Consensus 437 ~~~~~l~~~l~~-~~f~G~~G~~v~Fd~~G~~~~~~~-i~~~~~~~~~~~~~~Vg 489 (908) .+++.+.+.|++ ..|.|.+| .+.|+++|++...+. +.++. ++.++.+| T Consensus 306 ~~~~~~~~~l~~~~~~~g~~G-~~~f~~~g~~~~~~~~~~~~~----~g~~~~~~ 355 (356) T 4MLC_A 306 THPATLAQGLRDLGPWEGVMG-MHRFDGRGDDIGDLVVLKKMK----DGRFEYLG 355 (356) T ss_dssp SSTTHHHHHHHHHCSEEETTE-EECBCTTCCBCSSCEEEEEEE----TTEEEEC- T ss_pred CCHHHHHHHHHhhCCCCCcce-eEEECCCCCcccceEEEEEEE----CCEEEEcC Confidence 134457777877 47899988 899999888765433 44443 24555554 No 91 >4Q6B_A Extracellular ligand-binding receptor; Structural Genomics, PSI-Biology, Midwest Center; 1.667A {Desulfitobacterium hafniense} Probab=99.51 E-value=1.1e-18 Score=185.42 Aligned_cols=346 Identities=20% Similarity=0.252 Sum_probs=211.0 Template_Neff=12.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.+. .+.....+++.|++++|+.+++ .|.++++.+.|+.+++.. ..+. T Consensus 5 ~~~~~~~~Ig~~~~~~~--------------~~~~~~~~~~~a~~~~n~~~~~-~g~~~~~~~~d~~~~~~~----~~~~ 65 (356) T 4Q6B_A 5 VNPSEEIFIGVAWPFAS--------------LDDLFAEGLELAVQEINEQGGV-QGRKLSLVKADDEAELEK----GLAI 65 (356) T ss_dssp ----CEEEEEEEECTTT--------------CCSSHHHHHHHHHHHHHHTTCB-TTBEEEEEEEECTTCHHH----HHHH T ss_pred cCCCCcEEEEEEcCCCC--------------ccHHHHHHHHHHHHHHHHcCCc-CCeeEEEEEEcCcccHHH----HHHH Confidence 34567899999999642 3456788999999999987654 367788888887665432 2333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++++. .++++++|++.++.....+...+...++|+|++....+.+... .+++++++.+++ T Consensus 66 ~~~l~~------------------~~~v~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~ 126 (356) T 4Q6B_A 66 AQAFAD------------------NAGIQAVIGHRNSFISIPAASIYDQAGLVMLSPASTSPDLTDH-GYIHVFRNIPSD 126 (356) T ss_dssp HHHHHT------------------CTTEEEEECCSSHHHHHHHHHHHHHHTCCEEESSCCCGGGGSS-CCSSEEESSCCH T ss_pred HHHHHH------------------cCCccEEEcCCCchhhHHHHHHHHHhCCeEEEcCcCCcccccC-CCCCeEECCCCH Confidence 333332 1478999988776666666777888999999887655443221 356788899988 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) ...++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++++++ T Consensus 127 ~~~~~~~~~~l~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~v~ 202 (356) T 4Q6B_A 127 QEIARQLAIYLAEQGHERMVIYYTDDSYGNGLANAFEDYARAQ-GITIVDRFNYY--GNLKDLERLYDKWQA-FGMDGIF 202 (356) T ss_dssp HHHHHHHHHHHHHTTCCEEEEEECSSHHHHHHHHHHHHHHHHT-TCEEEEEESCC--CSHHHHHHHHHHHHH-TTCCEEE T ss_pred HHHHHHHHHHHHHcCCCEEEEEEcCCcchhHHHHHHHHHHHHC-CCeEeEEEecC--CCCccHHHHHHHHHH-cCCCEEE Confidence 8888999999888899999999966667777888888888775 45554322221 122345556666653 4778887 Q NP_000836.2 280 MFANE-DDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAP--VYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 280 ~~~~~-~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~--~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) +.... ..+..+++++++.|+. .+|++.+.|...... .........+.+..... ... ...+.. T Consensus 203 ~~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------~~~---~~~~~~ 267 (356) T 4Q6B_A 203 IAKTATGGGTEFLVDAKSVGIE--VPLIAGNSWDALSLTEDIENIGMTAEGLLVGSFF----------NPQ---RPDSRT 267 (356) T ss_dssp EESCCCCCCHHHHHHHHHHTCC--SCEEECGGGTCC-----------TTTTCEEEEEC----------CTT---CCCHHH T ss_pred EEecCccchHHHHHHHHHcCCC--CCEEecCccchhchHHHHHHhhhhhcCeEEEecC----------CCC---CCChhH Confidence 76543 3567788888887773 456655544321100 00000111121111100 000 000111 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMST 436 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~ 436 (908) ..|.+.+++.++ ..++.++..+|||++++++|+++... T Consensus 268 ~~f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~--------------- 305 (356) T 4Q6B_A 268 QDFVEAFRREYG---------------------------QPPTSYAAAGYDAVILLAEALEKSDL--------------- 305 (356) T ss_dssp HHHHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHTSCT--------------- T ss_pred HHHHHHHHHHHC---------------------------CCCCHHHHHHHHHHHHHHHHHHhCCC--------------- Confidence 122222222111 11235677899999999999987642 Q NP_000836.2 437 IDGKELLGYIRA-VNFNGSAGTPVTFNENGDAPGRYD-IFQYQITNKSTEYKVIG 489 (908) Q Consensus 437 ~~~~~l~~~l~~-~~f~G~~G~~v~Fd~~G~~~~~~~-i~~~~~~~~~~~~~~Vg 489 (908) .+++.+.+.|++ ..|.|.+| .+.|+++|++...+. +.++. ++.++.+| T Consensus 306 ~~~~~~~~~l~~~~~~~g~~G-~~~f~~~g~~~~~~~~~~~~~----~g~~~~~~ 355 (356) T 4Q6B_A 306 THPATLAQGLRDLGPWEGVMG-MHRFDGRGDDIGDLVVLKKMK----DGRFEYLG 355 (356) T ss_dssp TCGGGHHHHHHHTCSEEETTE-EECBCTTSCBCSSCEEEEEEE----TTEEEEC- T ss_pred CCHHHHHHHHHhhCCCCCcce-eEEECCCCCcccceEEEEEEE----CCEEEEcC Confidence 134457777877 47899988 899999888765433 44443 24555554 No 92 >3TD9_A Branched chain amino acid ABC; leucine binding, Structural Genomics, Joint; HET: EDO, PHE; 1.9A {Thermotoga maritima} Probab=99.51 E-value=1.1e-18 Score=186.24 Aligned_cols=347 Identities=22% Similarity=0.238 Sum_probs=217.8 Template_Neff=11.700 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) -++++||++.|.++... ..+.....|++.|++++|.. .|+++++.+.|+.+++.. ..+.+++ T Consensus 14 ~~~i~ig~~~p~sg~~~----------~~~~~~~~g~~~a~~~~~~~----~g~~v~l~~~d~~~~~~~----~~~~~~~ 75 (366) T 3TD9_A 14 RKVVKIAVILPMTGGIS----------AFGRMVWEGIQIAHEEKPTV----LGEEVELVLLDTRSEKTE----AANAAAR 75 (366) T ss_dssp --CEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHCCEE----TTEEEEEEEEECTTCHHH----HHHHHHH T ss_pred CCceEEEEEEccCCCch----------HHHHHHHHHHHHHHHhCCCC----CCeEEEEEEEcCCCCHHH----HHHHHHH Confidence 46799999999987532 35677889999999988642 367788888887655332 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .+++++++++.++.....+...+...++|+|.+.+..+.+.. ..++++++.+++... T Consensus 76 l~~------------------~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~~~ 135 (366) T 3TD9_A 76 AID------------------KEKVLAIIGEVASAHSLAIAPIAEENKVPMVTPASTNPLVTQ--GRKFVSRVCFIDPFQ 135 (366) T ss_dssp HHH------------------TSCCSEEEECSSHHHHHHHHHHHHHTTCCEEESSCCCGGGTT--TCSSEEESSCCHHHH T ss_pred HHH------------------hcCccEEEccCCchHHHHHHHHHHHcCCCEEccCCCCccccC--CCceeeEecCCcHHH Confidence 332 147889999877766666777788899999998776544322 246778888888888 Q NP_000836.2 203 AQAMVDIV-TALGWNYVSTLAS-EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l-~~~~~~~v~ii~~-~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ++.+++++ ++.+|+++++++. ++.++..+.+.+++.+++. ++++.. ..+. ....+....+++++. .+++++++ T Consensus 136 ~~~~~~~l~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~~-g~~~~~-~~~~--~~~~~~~~~~~~~~~-~~~~~iv~ 210 (366) T 3TD9_A 136 GAAMAVFAYKNLGAKRVVVFTDVEQDYSVGLSNFFINKFTEL-GGQVKR-VFFR--SGDQDFSAQLSVAMS-FNPDAIYI 210 (366) T ss_dssp HHHHHHCCCCCSCCCEEEEEEETTCHHHHHHHHHHHHHHHHT-TCEEEE-EEEC--TTCCCCHHHHHHHHH-TCCSEEEE T ss_pred HHHHHHHHHHhcCCCEEEEEEeCCChhhHHHHHHHHHHHHHC-CCeEEE-EEEC--CCCCChHHHHHHHHh-hCCCEEEE Confidence 88888888 5578999999984 4556667778888877765 355432 1222 122345566666663 57888877 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ...+..+..+++++++.|+.. .+++.+.+...... ........+.+...... .. ....+....|. T Consensus 211 ~~~~~~~~~~~~~~~~~g~~~--~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~~--~~~~~~~~~f~ 275 (366) T 3TD9_A 211 TGYYPEIALISRQARQLGFTG--YILAGDGADAPELI-EIGGEAVEGLLFTTHYH----------PK--AASNPVAKKFV 275 (366) T ss_dssp CSCHHHHHHHHHHHHHTTCCS--EEEECGGGCSTHHH-HHHGGGGTTCEEEESCC----------GG--GCCSHHHHHHH T ss_pred cCCHHHHHHHHHHHHHcCCCc--EEEecCccCcHHHH-HHhhHHhCceEEEecCC----------cc--cCCCHHHHHHH Confidence 765566777888888888742 33433322211100 00011122322211100 00 00001111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++ ..++.++..+|||+++++++++++.. .+++ T Consensus 276 ~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~---------------~~~~ 313 (366) T 3TD9_A 276 EVYKEKYG---------------------------KEPAALNALGYDAYMVLLDAIERAGS---------------FDRE 313 (366) T ss_dssp HHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHTS---------------CCHH T ss_pred HHHHHHHC---------------------------CCCcHHHHHHHHHHHHHHHHHHHcCC---------------CCHH Confidence 22222111 11234677899999999999988642 1345 Q NP_000836.2 441 ELLGYIRAV-NFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 441 ~l~~~l~~~-~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .+.++|++. .|.|.+| ++.|+++|++...+.+.+++ ++.++.+|.|++. T Consensus 314 ~l~~~l~~~~~~~g~~G-~~~f~~~g~~~~~~~i~~~~----~~~~~~~~~w~~~ 363 (366) T 3TD9_A 314 KIAEEIRKTRNFNGASG-IINIDENGDAIKSVVVNIVK----NGSVDFEAVINPD 363 (366) T ss_dssp HHHHHHTTCCSEEETTE-EECBCTTSCBCCCEEEEEEE----TTEEEEEEEECGG T ss_pred HHHHHHHcCCCcccccE-EEEECCCCCccceEEEEEEE----CCEEEEeEEeCcc Confidence 677777765 7889888 89999988887788888886 3578888888753 No 93 >3N0W_B ABC branched chain amino acid; Receptor family ligand binding region; HET: MSE; 1.88A {Burkholderia xenovorans} Probab=99.50 E-value=1.7e-18 Score=185.85 Aligned_cols=350 Identities=13% Similarity=0.170 Sum_probs=216.8 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||+++|.++... ...+.....|++.|++++|. + ..|+++++.+.|+.+++.. ..+.++ T Consensus 3 ~~~~~~Ig~i~~~~~~~~---------~~~~~~~~~g~~~a~~~~~~--~-~~g~~i~~~~~d~~~~~~~----~~~~~~ 66 (379) T 3N0W_B 3 STGQVTLGVLTDMSSVYA---------DSAGKGSVAAVQLAIEDVGG--K-ALGQPVKLVSADYQMKTDV----ALSIAR 66 (379) T ss_dssp ---CCEEEEEECSSSTTT---------TTSHHHHHHHHHHHHHTTTT--E-ETTEECEEEEEECTTCHHH----HHHHHH T ss_pred CCccEEEEEEecCCCcch---------hhcCHHHHHHHHHHHHHhCC--c-cCCeeEEEEEEcCCCCHHH----HHHHHH Confidence 456899999999876421 01456788999999999972 2 2467788888887655432 333344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .+++++++++.++.....+...+...++|+|.+....+.+.....+++++++.++... T Consensus 67 ~l~~------------------~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~~ 128 (379) T 3N0W_B 67 EWFD------------------RDGVDAIFDVVNSGTALAINNLVKDKKKLAFITAAAADQIGGTECNGYGIGFLYNFTS 128 (379) T ss_dssp HHHH------------------TSCCCEEEECCSHHHHHHHHHHHHHHTCEEEECSCCCTTTTTTTCCSSEEECSCCHHH T ss_pred HHHH------------------HhCCCEEEeCCCHHHHHHHHHHHHhcCCeEEEcCccccccCCCccCCceeEcccCHHH Confidence 4332 1478899998777666666777888899999887655443322235678888888888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++++++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..++...+++++. .++|++++. T Consensus 129 ~~~~~~~~l~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~iv~~ 204 (379) T 3N0W_B 129 IVKTVVQAQLAKGYKTWFLMLPDAAYGDLMNAAIRRELTAG-GGQIVGSVRFP--FETQDFSSYLLQAKA-SGAQLIVST 204 (379) T ss_dssp HHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCCCCHHHHHHHHH-TTCSEEEEC T ss_pred HHHHHHHHHHHcCCCEEEEEccccHHHHHHHHHHHHHHHHC-CCEEEEEEEeC--CCCCChHHHHHHHHH-cCCCEEEEE Confidence 88888888877899999999976677888888888888775 35554332222 122345566677663 578888777 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQE-EIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~-~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ..+..+..+++++++.|+..++.+++.. +...... .... ....+.+.... +.. ...+....|. T Consensus 205 ~~~~~~~~~~~~~~~~g~~~~~~~~~~~-~~~~~~~-~~~~~~~~~g~~~~~~----------~~~----~~~~~~~~f~ 268 (379) T 3N0W_B 205 SGGAANINIMKQAREFGLPSKTQKVGGM-IDILTDV-KSAGLRVMQGQEYATS----------FYW----NMDDRTRAFA 268 (379) T ss_dssp CCHHHHHHHHHHHHTTTCSCSSCEEECC-BCCHHHH-HHHCHHHHTTCEEEES----------CCT----TSSHHHHHHH T ss_pred cChHHHHHHHHHHHHcCCCccceeeech-hhHHHHH-HHhchhhhcCCceecc----------ccc----CCCHHHHHHH Confidence 6666778888898888775333333321 1110000 0000 11112111100 000 0011112222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++ ..++.++..+|||+++++.|++++.. .+++ T Consensus 269 ~~~~~~~~---------------------------~~p~~~~~~~yda~~~~~~al~~~~~---------------~~~~ 306 (379) T 3N0W_B 269 KRFYAKMG---------------------------KMPTNNQAGGYSAALQYLKAVNAIGS---------------KDPQ 306 (379) T ss_dssp HHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHTC---------------CCHH T ss_pred HHHHHHHC---------------------------CCCChHHHHHHHHHHHHHHHHHHHCC---------------CCHH Confidence 22222211 11234567899999999999988642 2355 Q NP_000836.2 441 ELLGYIRAVNFN-GSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 441 ~l~~~l~~~~f~-G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) .+.++|++..|. |.+| .+.|+++|++...+.+.+++. .. ..+|.|.. T Consensus 307 ~l~~~l~~~~~~~g~~g-~~~f~~~~~~~~~~~i~~~~~----~~-~~~~~w~~ 354 (379) T 3N0W_B 307 KVFAYLKTIKFDDAVTR-HGTLRPGGRLVRDMYLVRAKK----PE-DQKGDWDY 354 (379) T ss_dssp HHHHHHTTCCBCSSSCC-SBEECTTSBEECCEEEEEECC----GG-GCCSTTCC T ss_pred HHHHHHhcCccccCCCC-ceeeCCCCcEEEeEEEEEEcC----Cc-cCCCChhh Confidence 677888877786 7788 899998887777788888873 12 45677764 No 94 >1PEA_A AMIDASE OPERON, ACETAMIDE; GENE REGULATOR, RECEPTOR, BINDING PROTEIN; 2.1A {Pseudomonas aeruginosa} SCOP: c.93.1.1 Probab=99.49 E-value=1.8e-18 Score=186.08 Aligned_cols=354 Identities=11% Similarity=0.073 Sum_probs=219.0 Template_Neff=11.900 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|.++... ..+.....+++.|++++|+.+++. |+++++.+.|+.+++.. ..+.++ T Consensus 4 ~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~g~~~-g~~i~~~~~d~~~~~~~----~~~~~~ 68 (385) T 1PEA_A 4 HQERPLIGLLFSETGVTA----------DIERSQRYGALLAVEQLNREGGVG-GRPIETLSQDPGGDPDR----YRLCAE 68 (385) T ss_dssp ----CEEEEECCSSSTTH----------HHHHHHHHHHHHHHHHHHTTTTBT-TBCCEEEEECCTTCHHH----HHHHHH T ss_pred CCCCCEEEEEEcCCCCcc----------hHHHHHHHHHHHHHHHHHHcCCcC-CeeeEEEEECCCCCHHH----HHHHHH Confidence 457899999999876421 256678899999999999876543 67888888887665432 233334 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++++++|++.++.....+...+...++|+|++....+. ...++++++.++... T Consensus 69 ~l~~------------------~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~----~~~~~~~~~~~~~~~ 126 (385) T 1PEA_A 69 DFIR------------------NRGVRFLVGCYMSHTRKAVMPVVERADALLCYPTPYEGF----EYSPNIVYGGPAPNQ 126 (385) T ss_dssp HHHH------------------TTCCCEEEECCSHHHHHHHHHHHHHTTCEEEECSCCCCC----CCCTTEEECSCCGGG T ss_pred HHHH------------------hcCceEEEeccccHHHHhhHHHHhhcCCEEEecCCCCCC----CCCCcEEEecCChhh Confidence 3332 147889999887766667777888899999988764321 124678888888888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++.+++++.+.+|++|++++.++.++..+.+.+++.+++. ++++.....+.......++...+++++. .++|++++. T Consensus 127 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~ii~~ 204 (385) T 1PEA_A 127 NSAPLAAYLIRHYGERVVFIGSDYIYPRESNHVMRHLYRQH-GGTVLEEIYIPLYPSDDDLQRAVERIYQ-ARADVVFST 204 (385) T ss_dssp THHHHHHHHHTTTCSEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEECSSCCHHHHHHHHHHHHH-HTCSEEEEE T ss_pred hhHHHHHHHHHHhCCcEEEEecCCcchHHHHHHHHHHHHHC-CCeEEEEEEeCCCCCchhHHHHHHHHHH-cCCCEEEEE Confidence 88889999887899999999976677778888888888765 3555432211110112345566666663 578888777 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ..+..+..+++++++.|+.. .+.|+..+ ...... .........+.+...+.. . ....+....|. T Consensus 205 ~~~~~~~~~~~~~~~~g~~~~~~~~~~~~-~~~~~~-~~~~~~~~~~~~~~~~~~----------~---~~~~~~~~~f~ 269 (385) T 1PEA_A 205 VVGTGTAELYRAIARRYGDGRRPPIASLT-TSEAEV-AKMESDVAEGQVVVAPYF----------S---SIDTPASRAFV 269 (385) T ss_dssp CCTHHHHHHHHHHHHHHCSSCCCCEEESS-CCHHHH-TTSCHHHHTTCEEEESCC----------T---TCSSHHHHHHH T ss_pred ccchHHHHHHHHHHHHhCCCCCCCeeEee-CCHHHH-HhcccchhcCCEEEeccc----------c---CCCCHHHHHHH Confidence 66667778888888877542 33444332 111000 000011122222111100 0 00011112222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++. ...+..++..+||++++++.++++... .+++ T Consensus 270 ~~~~~~~~~-------------------------~~~~~~~~~~~yda~~~~~~a~~~~~~---------------~~~~ 309 (385) T 1PEA_A 270 QACHGFFPE-------------------------NATITAWAEAAYWQTLLLGRAAQAAGN---------------WRVE 309 (385) T ss_dssp HHHHTTSCT-------------------------TCCCCHHHHHHHHHHHHHHHHHHHHTS---------------CCHH T ss_pred HHHHHhCCC-------------------------CCCCCHHHHHHHHHHHHHHHHHHHhCC---------------CCHH Confidence 222221110 011234677899999999999987642 1345 Q NP_000836.2 441 ELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 441 ~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) .+.+.|++..|.|.+| ++.|+++|++. ..+.+.+++. ++.++.++.++. T Consensus 310 ~l~~~l~~~~~~g~~g-~~~f~~~~~~~~~~~~i~~~~~---~g~~~~~~~~~~ 359 (385) T 1PEA_A 310 DVQRHLYDIDIDAPQG-PVRVERQNNHSRLSSRIAEIDA---RGVFQVRWQSPE 359 (385) T ss_dssp HHHHHHTTCCEEETTE-EEEECTTTSCEEBCCEEEEECT---TSCEEEEEECSS T ss_pred HHHHHHhcCCcccCCc-eEEEeCCCCeeeeeeEEEEEcC---CCCEeEEEeCCC Confidence 6778888888999988 89999766653 4667777752 246777776654 No 95 >1QO0_B AMIC, AMIR; BINDING PROTEIN, GENE REGULATOR, RECEPTOR; HET: BMD; 2.25A {PSEUDOMONAS AERUGINOSA} SCOP: c.93.1.1 Probab=99.49 E-value=1.8e-18 Score=186.08 Aligned_cols=354 Identities=11% Similarity=0.073 Sum_probs=219.8 Template_Neff=11.900 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|.++... ..+.....+++.|++++|+.+++. |+++++.+.|+.+++.. ..+.++ T Consensus 4 ~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~g~~~-g~~i~~~~~d~~~~~~~----~~~~~~ 68 (385) T 1QO0_B 4 HQERPLIGLLFSETGVTA----------DIERSQRYGALLAVEQLNREGGVG-GRPIETLSQDPGGDPDR----YRLCAE 68 (385) T ss_dssp ---CCEEEEECCSSSTTH----------HHHHHHHHHHHHHHHHHHHTTTBT-TBCCEEEECCCTTCHHH----HHHHHH T ss_pred CCCCCEEEEEEcCCCCcc----------hHHHHHHHHHHHHHHHHHHcCCcC-CeeeEEEEECCCCCHHH----HHHHHH Confidence 457899999999876421 256678899999999999876543 67888888887665432 233334 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++++++|++.++.....+...+...++|+|++....+. ...++++++.++... T Consensus 69 ~l~~------------------~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~----~~~~~~~~~~~~~~~ 126 (385) T 1QO0_B 69 DFIR------------------NRGVRFLVGCYMSHTRKAVMPVVERADALLCYPTPYEGF----EYSPNIVYGGPAPNQ 126 (385) T ss_dssp HHHH------------------HSCCCEEEECCSHHHHHHHHHHHHHHTCEEEECSCCCCC----CCCTTEEECSCCGGG T ss_pred HHHH------------------hcCceEEEeccccHHHHhhHHHHhhcCCEEEecCCCCCC----CCCCcEEEecCChhh Confidence 3332 147889999887766667777888899999988764321 124678888888888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++.+++++.+.+|++|++++.++.++..+.+.+++.+++. ++++.....+.......++...+++++. .++|++++. T Consensus 127 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~ii~~ 204 (385) T 1QO0_B 127 NSAPLAAYLIRHYGERVVFIGSDYIYPRESNHVMRHLYRQH-GGTVLEEIYIPLYPSDDDLQRAVERIYQ-ARADVVFST 204 (385) T ss_dssp THHHHHHHHHHHSCSEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEECSSCCHHHHHHHHHHHHH-HTCSEEEEE T ss_pred hhHHHHHHHHHHhCCcEEEEecCCcchHHHHHHHHHHHHHC-CCeEEEEEEeCCCCCchhHHHHHHHHHH-cCCCEEEEE Confidence 88889999887899999999976677778888888888765 3555432211110112345566666663 578888777 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ..+..+..+++++++.|+.. .+.|+..+ ...... .........+.+...+.. . ....+....|. T Consensus 205 ~~~~~~~~~~~~~~~~g~~~~~~~~~~~~-~~~~~~-~~~~~~~~~~~~~~~~~~----------~---~~~~~~~~~f~ 269 (385) T 1QO0_B 205 VVGTGTAELYRAIARRYGDGRRPPIASLT-TSEAEV-AKMESDVAEGQVVVAPYF----------S---SIDTPASRAFV 269 (385) T ss_dssp CCSTTHHHHHHHHHHHSCSSSCCCEEESS-CCHHHH-TTSCHHHHTTCEEEESCC----------T---TCCSHHHHHHH T ss_pred ccchHHHHHHHHHHHHhCCCCCCCeeEee-CCHHHH-HhcccchhcCCEEEeccc----------c---CCCCHHHHHHH Confidence 66667778888888877542 33444332 111000 000011122222111100 0 00011112222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++. ...+..++..+||++++++.++++... .+++ T Consensus 270 ~~~~~~~~~-------------------------~~~~~~~~~~~yda~~~~~~a~~~~~~---------------~~~~ 309 (385) T 1QO0_B 270 QACHGFFPE-------------------------NATITAWAEAAYWQTLLLGRAAQAAGN---------------WRVE 309 (385) T ss_dssp HHHHTTSCT-------------------------TCCCCHHHHHHHHHHHHHHHHHHHHTS---------------CCHH T ss_pred HHHHHhCCC-------------------------CCCCCHHHHHHHHHHHHHHHHHHHhCC---------------CCHH Confidence 222221110 011234677899999999999987642 1345 Q NP_000836.2 441 ELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 441 ~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) .+.+.|++..|.|.+| ++.|+++|++. ..+.+.+++. ++.++.++.++. T Consensus 310 ~l~~~l~~~~~~g~~g-~~~f~~~~~~~~~~~~i~~~~~---~g~~~~~~~~~~ 359 (385) T 1QO0_B 310 DVQRHLYDIDIDAPQG-PVRVERQNNHSRLSSRIAEIDA---RGVFQVRWQSPE 359 (385) T ss_dssp HHHHTTTTCCEEETTE-EEEECTTTSBEEBCCEEEEECT---TSCEEEEEECSS T ss_pred HHHHHHhcCCcccCCc-eEEEeCCCCeeeeeeEEEEEcC---CCCEeEEEeCCC Confidence 6778888888999988 89999766653 4667777752 246777776654 No 96 >4KV7_A Probable leucine/isoleucine/valine-binding protein; structural genomics, PSI-Biology, Protein Structure; 1.2A {Rhodopirellula baltica} Probab=99.49 E-value=1.9e-18 Score=185.53 Aligned_cols=349 Identities=15% Similarity=0.149 Sum_probs=214.2 Template_Neff=11.900 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ......++++||+++|.++... ..+.....+++.|++++|+.+++. |+++++.+.|+++++.. .. T Consensus 10 ~~~~~~~~~~Ig~~~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~~~~~-g~~i~~~~~d~~~~~~~----~~ 74 (381) T 4KV7_A 10 ATPVDAQLLKFGMSTALSGPAA----------ELGINMRHGILAAFDEAKAKNHLP-SKTLKLIALDDGYEPAR----TA 74 (381) T ss_dssp CCCCCCEEEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHHHHTTSST-TEEEEEEEEECTTCHHH----HH T ss_pred CCCCCcceEEEEEEeCCCCccH----------HHHHHHHHHHHHHHHHHHHhCCCC-CceeEEEEEcCCCCHhh----HH Confidence 3455678999999999876421 256678899999999999876543 67888888887766433 33 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +.+++++. .++++++|++.++.....+...+...+||+|.+....+.+.....+++++++.+ T Consensus 75 ~~~~~l~~------------------~~~~~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~ 136 (381) T 4KV7_A 75 PNMHRLTD------------------EHEVLAVVGNVGTPTAITAIPIAQQTKTPFFGAFTGASALRKTESVEFVINYRA 136 (381) T ss_dssp HHHHHHHT------------------TTCCSCEECCBCHHHHHHHHHHHHHTTCCEESCBCCCGGGCC---CTTEEBCSC T ss_pred HHHHHHHh------------------hCCeeEEEeCCCcHHHHHHHHHHHhhCCCEEeeecCchHhcCCCCCceEEECCc Confidence 33444332 147889999887776677778888999999998776554432224677888989 Q NP_000836.2 198 PDSYQAQAMVDIVTA--LGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQ--KIPREPRPGEFEKIIKRLLE-T 272 (908) Q Consensus 198 ~~~~~~~~~~~~l~~--~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~--~~~~~~~~~~~~~~~~~l~~-~ 272 (908) +....+.++++++.+ .+|++|++++.++.++....+.+.+.+++..++++.... .+. .+..++...+++++. . T Consensus 137 ~~~~~~~~~~~~l~~~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~g~~v~~~~~~~~~--~~~~~~~~~~~~~~~~~ 214 (381) T 4KV7_A 137 SYAEETAAMVDALVAKGIKPEEIGFFTQNDSYGDDGFFGGLAAIRRHQSVKVSSLPHGRYR--RNTSQVEDGLADLLMHQ 214 (381) T ss_dssp CHHHHHHHHHHHHHHTTCCGGGEEEEEESSHHHHHHHHHHHHHHHHHSCCCGGGSCEEEEC--TTCCCCHHHHHHHHTCS T ss_pred CHHHHHHHHHHHHHHCCCCccEEEEEEeCCcchHhhHHHHHHHHHHcCCCcceecCCCCCC--CCCccHHHHHHHHHhcC Confidence 888888889988854 578999999976667777777888777652134443211 111 112344555666541 2 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLAN 352 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~ 352 (908) .++|+|++...+..+..+++++++.|+. ..|++.+.+...... ........+.+....... . ... T Consensus 215 ~~~~~i~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~--------~----~~~ 279 (381) T 4KV7_A 215 PLPKAVIMVGTYEPCSKLIRMARMNNFN--PQFLAVSFVGADALQ-RSLGDLANGIVATQVVPH--------F----DSD 279 (381) T ss_dssp SCCSEEEEESCHHHHHHHHHHHHHTTCC--CEEEECGGGCHHHHH-HHHGGGGTTCEEEESSCC--------T----TCC T ss_pred CCCCEEEEECChHHHHHHHHHHHhCCCC--CcEEEEeccCHHHHH-HHHHHhcccEEEEEeeCC--------C----CCC Confidence 4688887776666677888888887764 345554433221110 000111222221110000 0 000 Q NP_000836.2 353 NRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCP 432 (908) Q Consensus 353 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~ 432 (908) .+....|.+.+++.+.. .....++..+|||++++++++++.... T Consensus 280 ~~~~~~f~~~~~~~~~~--------------------------~~~~~~~~~~yda~~~~~~al~~~~~~---------- 323 (381) T 4KV7_A 280 LPLVREYRDAMRDYDPE--------------------------LPLSFVSLEGYIVGRILVKAVTSIKGE---------- 323 (381) T ss_dssp SHHHHHHHHHHHHHCTT--------------------------SCCCHHHHHHHHHHHHHHHHHHHCCSC---------- T ss_pred CHHHHHHHHHHHHhCCC--------------------------CCCChhhHHHHHHHHHHHHHHHhcCCC---------- Confidence 01111222222211110 112345778999999999999876421 Q NP_000836.2 433 RMSTIDGKELLGYIRAV-NFN-GSAGTPVTFNENGDAP-GRYDIFQYQ 477 (908) Q Consensus 433 ~~~~~~~~~l~~~l~~~-~f~-G~~G~~v~Fd~~G~~~-~~~~i~~~~ 477 (908) .+++.+.+.|++. .|. |.+| ++.|+++|++. ..+.+++++ T Consensus 324 ----~~~~~l~~~l~~~~~~~~g~~g-~i~f~~~~~~~~~~~~i~~~~ 366 (381) T 4KV7_A 324 ----ISRSSIAAALEQLGQFDIGLGA-PLTLGPNDHQASSKVWPVLIG 366 (381) T ss_dssp ----CCHHHHHHHHHHTEEECSSSSS-CEEEBTTBCBCCCCCEEEEEC T ss_pred ----CCHHHHHHHHHHcCCCcCCCCC-CcccCCCCCcccccEEEEEEc Confidence 2345677788766 787 7777 89999876543 456666665 No 97 >4OBB_B Amino acid/amide ABC transporter substrate-binding; STRUCTURAL GENOMICS, PSI-BIOLOGY, MIDWEST CENTER; HET: 1QQ, MSE; 1.526A {Anabaena variabilis} Probab=99.49 E-value=2e-18 Score=186.37 Aligned_cols=362 Identities=16% Similarity=0.184 Sum_probs=213.9 Template_Neff=11.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||+++|.++... ..+.....+++.|++++|+.+++ .|+++++.+.|+.+++.. ..+ T Consensus 27 ~~~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~~~~-~g~~i~~~~~d~~~~~~~----~~~ 91 (395) T 4OBB_B 27 TTSDKNTIPIGIALAQTSNVA----------LLGQEQVAGAKIAEKYFNDKGGV-NGTPIKLIFQDTAGDEAG----TIN 91 (395) T ss_dssp -----CCEEEEECCCCSSTTH----------HHHHHHHHHHHHHHHHHHHTTTB-TTBCEEEEECCCTTSHHH----HHH T ss_pred CCccCCcEEEEEEECCCCCcH----------HHHHHHHHHHHHHHHHHHHcCCC-CCeeeEEEEEcCCCCHHH----HHH Confidence 345678999999999875321 24567889999999999987654 367788887776655332 233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++++.+ .+++++|++.++.....+...+...+||+|.+....+.+.. .+++++++.++ T Consensus 92 ~~~~l~~~------------------~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~ 151 (395) T 4OBB_B 92 AFQTLINK------------------DKVVGIVGPTLSQQAFSANPIAERAKVPVVGPSNTAKGIPE--IGDYVARVSAP 151 (395) T ss_dssp HHHCCCCC------------------SCCSCEECCSCHHHHHHHHHHHHHHTCCEEESSCCSTTSGG--GCTTEEESSCC T ss_pred HHHHHHhc------------------CCccEEECCCChhHHHHHHHHHHHhCCCEEcCCcCCCcCCC--CCCeEEEecCC Confidence 33433321 46788888876665566677788899999998765543321 24677888888 Q NP_000836.2 199 DSYQAQAMVDIVT--ALGWNYVSTLA-SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNA 275 (908) Q Consensus 199 ~~~~~~~~~~~l~--~~~~~~v~ii~-~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 275 (908) +...+..+++.+. ..+|+++++++ .++.++..+.+.|++.+++. ++++.....+. ....+....+++++. .++ T Consensus 152 ~~~~~~~~~~~l~~~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~ 227 (395) T 4OBB_B 152 VSVVAPNSVKAALKQNPNIKKVAVFFAQNDAFSKSETEIFQQTVKDQ-GLELVTVQKFQ--TTDTDFQSQATNAIN-LKP 227 (395) T ss_dssp HHHHTHHHHHHHHHHCTTCCEEEEEEETTCHHHHHHHHHHHHHHHHH-TCEEEEEEEEC--TTCCCCHHHHHHHHT-TCC T ss_pred hHHhchHHHHHHHHhCCCCCEEEEEEecCChHhHHHHHHHHHHHHHC-CCeEEEEEEeC--CCCCCHHHHHHHHHh-hCC Confidence 8777777776543 56899999998 45556777788888887765 35544322222 122344555666653 478 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRR 355 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 355 (908) ++|++...+..+..+++++++.|+. ..|++.+.+...... ........+.+...... . ....+. T Consensus 228 ~~i~~~~~~~~~~~~~~~~~~~g~~--~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~---~~~~~~ 291 (395) T 4OBB_B 228 DLVIISGLAADGGNLVRQLRELGYQ--GAIIGGNGLNTSNVF-AVCKALCDGVLIAQAYS----------P---EYTGEI 291 (395) T ss_dssp SEEEEESCHHHHHHHHHHHHHTTCC--SEEEECGGGCSGGGH-HHHGGGGTTCEEEESCC----------T---TCCCHH T ss_pred CEEEEECChhhHHHHHHHHHHcCCC--ceEEecCccCCHHHH-HHhHHHhCCeEEeecCC----------c---ccCCHH Confidence 8887776566677888888888774 356655433221100 00011122222111100 0 000011 Q NP_000836.2 356 NVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMS 435 (908) Q Consensus 356 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~ 435 (908) ...|.+.+.+.++ ..+..++..+|||++++++++++....... .+. .. T Consensus 292 ~~~f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~~~~~----~~~-~~ 339 (395) T 4OBB_B 292 NKAFRQAYVDQYK---------------------------KEPPQFSAQAFAAVQVYVESLKALDTKNKV----SKI-QL 339 (395) T ss_dssp HHHHHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHHHHSCG----GGS-CH T ss_pred HHHHHHHHHHHHC---------------------------CCCChHHHHHHHHHHHHHHHHHHccccCCC----ccc-cH Confidence 1122222222111 112356788999999999999887642100 000 00 Q NP_000836.2 436 TIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 436 ~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) ....+.+.+.+++..|.|.+| ++.||++|++. ..+.+++++. ..+..+|.|. T Consensus 340 ~~~~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~~i~~~~~----~~~~~~~~~~ 392 (395) T 4OBB_B 340 PELRTELNKQLLTGKYNTPLG-EISFTPIGEVVQKDFYVAQIKM----EKDGSQGKFT 392 (395) T ss_dssp HHHHHHHHHHHHHCEEEETTE-EEEECTTSCEECCCCEEEEEEE----CTTSSCEEEE T ss_pred HHHHHHHHHHHhhCCCcCCcE-EEEECCCCCccCccEEEEEEEc----cccCCcceEE Confidence 011223444455568999988 89999988875 6788888763 2344556554 No 98 >4RV5_B Amino acid/amide ABC transporter substrate-binding; Structural Genomics, PSI-Biology, Protein Structure; HET: PYR, MSE, FMT; 1.04A {Anabaena variabilis ATCC 29413} Probab=99.49 E-value=2e-18 Score=186.37 Aligned_cols=362 Identities=16% Similarity=0.184 Sum_probs=213.9 Template_Neff=11.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||+++|.++... ..+.....+++.|++++|+.+++ .|+++++.+.|+.+++.. ..+ T Consensus 27 ~~~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~~~~-~g~~i~~~~~d~~~~~~~----~~~ 91 (395) T 4RV5_B 27 TTSDKNTIPIGIALAQTSNVA----------LLGQEQVAGAKIAEKYFNDKGGV-NGTPIKLIFQDTAGDEAG----TIN 91 (395) T ss_dssp -----CCEEEEECCCCSSTTH----------HHHHHHHHHHHHHHHHHHHTTTB-TTBCEEEEECCCTTSHHH----HHH T ss_pred CCccCCcEEEEEEECCCCCcH----------HHHHHHHHHHHHHHHHHHHcCCC-CCeeeEEEEEcCCCCHHH----HHH Confidence 345678999999999875321 24567889999999999987654 367788887776655332 233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++++.+ .+++++|++.++.....+...+...+||+|.+....+.+.. .+++++++.++ T Consensus 92 ~~~~l~~~------------------~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~ 151 (395) T 4RV5_B 92 AFQTLINK------------------DKVVGIVGPTLSQQAFSANPIAERAKVPVVGPSNTAKGIPE--IGDYVARVSAP 151 (395) T ss_dssp HHHHHHHT------------------SCCSCEECCSCHHHHHHHHHHHHHHTCCEEESSCCSTTSGG--GCTTEEESSCC T ss_pred HHHHHHhc------------------CCccEEECCCChhHHHHHHHHHHHhCCCEEcCCcCCCcCCC--CCCeEEEecCC Confidence 33433321 46788888876665566677788899999998765543321 24677888888 Q NP_000836.2 199 DSYQAQAMVDIVT--ALGWNYVSTLA-SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNA 275 (908) Q Consensus 199 ~~~~~~~~~~~l~--~~~~~~v~ii~-~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 275 (908) +...+..+++.+. ..+|+++++++ .++.++..+.+.|++.+++. ++++.....+. ....+....+++++. .++ T Consensus 152 ~~~~~~~~~~~l~~~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~ 227 (395) T 4RV5_B 152 VSVVAPNSVKAALKQNPNIKKVAVFFAQNDAFSKSETEIFQQTVKDQ-GLELVTVQKFQ--TTDTDFQSQATNAIN-LKP 227 (395) T ss_dssp HHHHHHHHHHHHHHHCTTCCEEEEEEETTCHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCCCCHHHHHHHHT-TCC T ss_pred hHHhchHHHHHHHHhCCCCCEEEEEEecCChHhHHHHHHHHHHHHHC-CCeEEEEEEeC--CCCCCHHHHHHHHHh-hCC Confidence 8777777776543 56899999998 45556777788888887765 35544322222 122344555666653 478 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRR 355 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 355 (908) ++|++...+..+..+++++++.|+. ..|++.+.+...... ........+.+...... . ....+. T Consensus 228 ~~i~~~~~~~~~~~~~~~~~~~g~~--~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~---~~~~~~ 291 (395) T 4RV5_B 228 DLVIISGLAADGGNLVRQLRELGYQ--GAIIGGNGLNTSNVF-AVCKALCDGVLIAQAYS----------P---EYTGEI 291 (395) T ss_dssp SEEEEESCHHHHHHHHHHHHHTTCC--SEEEECGGGCSGGGH-HHHGGGGTTCEEEESCC----------T---TCCCHH T ss_pred CEEEEECChhhHHHHHHHHHHcCCC--ceEEecCccCCHHHH-HHhHHHhCCeEEeecCC----------c---ccCCHH Confidence 8887776566677888888888774 356655433221100 00011122222111100 0 000011 Q NP_000836.2 356 NVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMS 435 (908) Q Consensus 356 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~ 435 (908) ...|.+.+.+.++ ..+..++..+|||++++++++++....... .+. .. T Consensus 292 ~~~f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~~~~~----~~~-~~ 339 (395) T 4RV5_B 292 NKAFRQAYVDQYK---------------------------KEPPQFSAQAFAAVQVYVESLKALDTKNKV----SKI-QL 339 (395) T ss_dssp HHHHHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHHHHSCG----GGS-CH T ss_pred HHHHHHHHHHHHC---------------------------CCCChHHHHHHHHHHHHHHHHHHccccCCC----ccc-cH Confidence 1122222222111 112356788999999999999887642100 000 00 Q NP_000836.2 436 TIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 436 ~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) ....+.+.+.+++..|.|.+| ++.||++|++. ..+.+++++. ..+..+|.|. T Consensus 340 ~~~~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~~i~~~~~----~~~~~~~~~~ 392 (395) T 4RV5_B 340 PELRTELNKQLLTGKYNTPLG-EISFTPIGEVVQKDFYVAQIKM----EKDGSQGKFT 392 (395) T ss_dssp HHHHHHHHHHHHHCEEEETTE-EEEECTTSCEECCCCEEEEEEE----CTTSSCEEEE T ss_pred HHHHHHHHHHHhhCCCcCCcE-EEEECCCCCccCccEEEEEEEc----cccCCcceEE Confidence 011223444455568999988 89999988875 6788888763 2344556554 No 99 >3I45_A Twin-arginine translocation pathway signal protein; STRUCTURAL GENOMICS, CRYSTAL STRUCTURE,PROTEIN STRUCTURE; 1.36A {Rhodospirillum rubrum} Probab=99.49 E-value=2.3e-18 Score=185.44 Aligned_cols=355 Identities=15% Similarity=0.137 Sum_probs=214.7 Template_Neff=11.600 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.++.. ..+.....|++.|++++|+.+++++|+++++...|+.+++.. ..+.+++ T Consensus 3 ~~~~~Ig~i~~~~~~~-----------~~~~~~~~g~~~a~~~~n~~~g~~~g~~v~~~~~d~~~~~~~----~~~~~~~ 67 (387) T 3I45_A 3 LEAIRIGEINSYSQIP-----------AFTLPYRNGWQLAVEQINAAGGLLGGRPLEVISRDDGGDPGK----AVTAAQE 67 (387) T ss_dssp CCCEEEEEEECTTTCH-----------HHHHHHHHHHHHHHHHHHHTTCBTTTBCEEEEEEECTTCHHH----HHHHHHH T ss_pred CCcEEEEEecCCCCCc-----------ccCHHHHHHHHHHHHHHHHCCCccCCceeEEEEecCCCCHHH----HHHHHHH Confidence 4689999999987532 245678899999999999987776678888888877655332 2333444 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++++++|++.++.....+...+...++|+|.+....+.+.+...+++++++.+++... T Consensus 68 l~~------------------~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 129 (387) T 3I45_A 68 LLT------------------RHGVHALAGTFLSHVGLAVSDFARQRKVLFMASEPLTDALTWEKGNRYTYRLRPSTYMQ 129 (387) T ss_dssp HHH------------------HHCCSEEEECCSHHHHHHHHHHHHHHTCCEEECSCCCGGGTTTTCCTTEEECSCCHHHH T ss_pred HHH------------------HhCCCEEEEcCChHHHHHHHHHHHHcCCEEEEcCCCChhHhhcCCCCcEEEeCCCHHHH Confidence 332 14789999987776666667778888999998776554433222357788999988888 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQ-KIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~-~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) +..+++++.+.+|+++++++.++.++..+.+.+++.+++. +..+.... .+.. ....+....+++++. .++|++++. T Consensus 130 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~-~~~~~~~~~~~~~~~-~~~~~ii~~ 206 (387) T 3I45_A 130 AAMLAAEAAKLPITRWATIAPNYEYGQSAVARFKELLLAA-RPEVTFVAEQWPA-LYKLDAGPTVQALQQ-AEPEGLFNV 206 (387) T ss_dssp HHHHHHHHTTSSCCEEEEECCSSHHHHHHHHHHHHHHHHH-CTTCEEEEEECCC-TTCCCHHHHHHHHHH-TCCSEEEEC T ss_pred HHHHHHHHhcCCCCEEEEEccCcHHhHHHHHHHHHHHHHh-CCCcEEEeeeccc-ccCCCcHHHHHHHHh-cCCCeEEEE Confidence 8899999888899999999976667777888888877764 22221111 1110 112344555666653 478888777 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQE-EIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~-~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ..+..+..+++++++.|+.....++ .......... .... ....+.+..... +. ....+....|. T Consensus 207 ~~~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~~---~~~~~~~~~f~ 271 (387) T 3I45_A 207 LFGADLPKFVREGRVRGLFAGRQVV-SMLTGEPEYL-NPLKDEAPEGWIVTGYP----------WY---DIDTAPHRAFV 271 (387) T ss_dssp CCTTHHHHHHHHHHHHTSSTTCEEE-EEEEESHHHH-GGGGGGCCSSCEEEECC----------GG---GCCCHHHHHHH T ss_pred cccccHHHHHHHHHHcCccCCCeEE-EEecCCHHHH-HhhcCCCCCCeEEecCC----------cc---cCCCHHHHHHH Confidence 5566677888888888775311111 1111111000 0000 111222111000 00 00011111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+.+.+. ..+..++..+||++++++.|++++.. .+++ T Consensus 272 ~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~a~~~~~~---------------~~~~ 309 (387) T 3I45_A 272 EAYRARWK---------------------------EDPFVGSLVGYNTLTAMAVAFEKAGG---------------TESE 309 (387) T ss_dssp HHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHTS---------------CCHH T ss_pred HHHHHHHC---------------------------CCCChHHHHHHHHHHHHHHHHHHhCC---------------CCHH Confidence 22222111 11234567899999999999988642 1345 Q NP_000836.2 441 ELLGYIRAVNFNGSAGTPVTFNE-NGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 441 ~l~~~l~~~~f~G~~G~~v~Fd~-~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .+.++|++..|.|.+| ++.|++ +++....+.+.+++..+ +.+ .++.|... T Consensus 310 ~i~~~l~~~~~~g~~G-~i~f~~~~~~~~~~~~i~~~~~~~--g~~-~~~~w~~~ 360 (387) T 3I45_A 310 TLVETLKDMAFSTPMG-PLSFRASDHQSTMGAWVGRTALRD--GKG-VMVDWRYV 360 (387) T ss_dssp HHHHHTTTCEEEETTE-EEEBCTTTCBBCCCEEEEEEEEET--TEE-EEEEEEEE T ss_pred HHHHHHhhCcccCCCe-eEEEcCCCCcccccEEEEEEEeeC--Cce-eEeeeEEE Confidence 6778888778999988 899987 34444566776665321 233 34466543 No 100 >4F06_A Extracellular ligand-binding receptor; PSI-BIOLOGY, MCSG, MIDWEST CENTER FOR; HET: PHB, SO4, GOL; 1.3A {Rhodopseudomonas palustris} Probab=99.48 E-value=2.9e-18 Score=183.24 Aligned_cols=356 Identities=12% Similarity=0.097 Sum_probs=217.6 Template_Neff=12.000 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCS-RDTYALEQSLTFV 120 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~-~~~~a~~~~~~~~ 120 (908) ..++++||++.|.++... ..+.....|++.|++++|. + ..|+++++.+.|+.+ ++.. ..+.+ T Consensus 2 ~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~~--~-~~g~~~~~~~~d~~~~~~~~----~~~~~ 64 (371) T 4F06_A 2 NADTIKVGVIGTMSGPYA----------LFGKNYKMGIDAWVAEHGN--K-VAGHTVEFVYRDEVSPNPAQ----SKALA 64 (371) T ss_dssp --CEEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHCS--E-ETTEEEEEEEEECCSSCHHH----HHHHH T ss_pred cCCceEEEEEEcCCCChh----------HhHHHHHHHHHHHHHHcCC--c-cCCEEEEEEEecCCCCCHHH----HHHHH Confidence 356899999999875421 2556788899999999883 1 246778888877664 4332 22333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .++++++|++.++.....+...+...++|+|.+....+.+.. ..++++++.++.. T Consensus 65 ~~l~~------------------~~~~~~vi~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~ 124 (371) T 4F06_A 65 QELIV------------------KEKVQYLAGLYFTPNAMAVAPLLQEAKVPMVVMNAATSSITE--KSPYIVRTSFTMF 124 (371) T ss_dssp HHHHH------------------TSCCSEEEECCSHHHHHHHGGGHHHHTCCEEESSCCCGGGGG--GCTTEEESSCCHH T ss_pred HHHHH------------------hcCCCEEEeCCCCHHHHHHHHHHHHcCCCEEEecCCCchhcc--CCCCEEEecCchh Confidence 44332 157899999776666666677788899999998765543322 2567888888888 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ..+..+++++.+.+|++|++++.++.++..+.+.+.+.+++. ++++.....+. ....+....+++++. .++|++++ T Consensus 125 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i~~ 200 (371) T 4F06_A 125 QNTVPAAKVAKQKGATKVAIAVSDYGPGIDAETAFKKTFEAE-GGKVVEAVRMP--LSTTDFGPIMQRIKN-SGADMIFT 200 (371) T ss_dssp HHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCCCCHHHHHHHHH-HTCSEEEE T ss_pred hcHHHHHHHHHHhCCCEEEEEEeCCcccHHHHHHHHHHHHHC-CCEEcEEEEcC--CCCCChHHHHHHHHH-cCCCEEEE Confidence 888888888888899999999966667777788888887765 35544322222 122344556666653 47888877 Q NP_000836.2 281 FA-NEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW 358 (908) Q Consensus 281 ~~-~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 358 (908) .+ ++..+..+++++++.|+.. ++.|++.+.+...... ........+.+..... .. ....+.... T Consensus 201 ~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~----------~~---~~~~~~~~~ 266 (371) T 4F06_A 201 FLPAGPPTLGFVKAYIDNGLKAGGVKLMSTGDVVTEPDL-PNIGEAGLGILSTYHY----------AV---SHDSPENKA 266 (371) T ss_dssp ECCTTHHHHHHHHHHHHTTTTTTTCEEEEEGGGGCGGGH-HHHCGGGTTCEEEESC----------CT---TCCSHHHHH T ss_pred eCCCChhHHHHHHHHHHCCcccCCceEEEeCCCCCCcch-hhhhhhcceeEEEecc----------cc---cCCCHHHHH Confidence 65 4556778888988888753 3566665433221110 0011111222211100 00 000111122 Q NP_000836.2 359 FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTID 438 (908) Q Consensus 359 ~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~ 438 (908) |.+.+++.+.. ...+..++..+||++++++++++++... .+ T Consensus 267 f~~~~~~~~~~-------------------------~~~~~~~~~~~yda~~~~~~al~~~~~~--------------~~ 307 (371) T 4F06_A 267 FLALLQKGGAK-------------------------LDEVTMTSVAAYDGARLIYKMIEATSGK--------------SD 307 (371) T ss_dssp HHHHHHHTTCC-------------------------GGGCCHHHHHHHHHHHHHHHHHHHTTTS--------------CC T ss_pred HHHHHHHcCCC-------------------------CCCCChHHHHHHHHHHHHHHHHHHcCCC--------------CC Confidence 33323221100 0012346778999999999999876421 23 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNEN-GDAPGRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~-G~~~~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) ++.+.+.|++.+|.|.+| ++.|+++ +++...+.+.+++..++...++.++.|. T Consensus 308 ~~~l~~~l~~~~~~g~~g-~~~f~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~ 361 (371) T 4F06_A 308 PDKAIAAVKGMKWVSPRG-EVSIDPETRHITQNVYLREVEKVDGKLINRELETFK 361 (371) T ss_dssp HHHHHHHHTTCEEEETTE-EEEECTTTCBEEEEEEEEEEEEETTEEEEEEEEEEE T ss_pred HHHHHHHHcCCCeecCCe-eEEEcccCCceeeeEEEEEEEeeCCEEEeeeeeecc Confidence 456778888888999888 8999974 4445677787776321123455555553 No 101 >4N03_A ABC-type branched-chain amino acid transport; structural genomics, fatty acid, PSI-Biology; HET: PLM; 1.15A {Thermomonospora curvata} Probab=99.46 E-value=4.8e-18 Score=184.10 Aligned_cols=356 Identities=14% Similarity=0.094 Sum_probs=221.3 Template_Neff=11.800 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||++.|.++... ..+.....+++.|++++|+.+++ .|+++++.+.|+.+++.. ..+. T Consensus 28 ~~~~~~i~Ig~i~~~~~~~~----------~~~~~~~~~~~~a~~~~n~~g~~-~g~~i~~~~~d~~~~~~~----~~~~ 92 (405) T 4N03_A 28 GVTDKTIKLGIATDLTGVYA----------PLGKSITQAQQLYYEEVNQRGGV-CGRTIEAVVRDHGYDPQK----AVSI 92 (405) T ss_dssp TBCSSEEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHHHHTTCB-TTBEEEEEEEECTTCHHH----HHHH T ss_pred CcCCCeEEEEEEeCCCCCCc----------chhHHHHHHHHHHHHHHHHcCCc-CCEeEEEEEEeCCCCHHH----HHHH Confidence 45678999999999875321 24567889999999999987654 367888888887655332 2233 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++++ ++++++|++.++.....+...+...++|+|....... .. ..++++++.+++ T Consensus 93 ~~~l~--------------------~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~-~~---~~~~~~~~~~~~ 148 (405) T 4N03_A 93 YTELN--------------------NNVLAIPHFLGSPMVSAVKQRIESDKMFTIPSAWTTA-LL---GSKYIQVTGTTY 148 (405) T ss_dssp HHHHT--------------------TTCSCEEEEECHHHHHHHHHHHHHHTCCEEEECCCGG-GC---SCTTBCCCSCCH T ss_pred HHHHH--------------------hhccEEeeccCChhHHHHHHHHHhcCCceecccccHH-Hc---CCCccccCCCCH Confidence 33322 2678888877666666666777888999986543322 11 246778888888 Q NP_000836.2 200 SYQAQAMVDIVTAL----GWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNA 275 (908) Q Consensus 200 ~~~~~~~~~~l~~~----~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 275 (908) ...+..+++++.+. +|++|++++.++.++..+.+.|++.+++. ++++.. ..+. ....++...+++++. .++ T Consensus 149 ~~~~~~~~~~l~~~~~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~-~~~~--~~~~~~~~~~~~~~~-~~~ 223 (405) T 4N03_A 149 DVDMINGVQWLMDKKLIKKGDKLGHVYFEGDYGGSALRGTKYAAEQL-GLEVFE-LPIK--PTDRDMKSQVAALAK-EKV 223 (405) T ss_dssp HHHHHHHHHHHHHTTSSCTTCEEEEEEETTHHHHHHHHHHHHHHHHH-TCEEEE-EEEC--TTCCCCHHHHHHHHH-TTC T ss_pred HHHHHHHHHHHHHccccCCCCEEEEEEecCcchhhHHHHHHHHHHHh-CCEEEE-eeeC--CCCCCHHHHHHHHHH-CCC Confidence 88888888887543 89999999976667777788888888765 355432 2221 122345566677763 578 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQE--EIAEGAVTILPKRASIDGFDRYFRSRTLANN 353 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~--~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~ 353 (908) |+|++...+..+..+++++++.|+. ..|++.+.+...... .... ....+.+....... . .... T Consensus 224 ~~vv~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~g~~~~~~~~~---------~---~~~~ 288 (405) T 4N03_A 224 DAILLSAGPQQAASLAGIARSQGMK--QPILGSNSAYSPQLL-ATPAKPALVEGFFIATAGAP---------M---SADL 288 (405) T ss_dssp SEEEEESCHHHHHHHHHHHHHTTCC--CCEEECTTSCCGGGG-GSTTHHHHSSSEEEEESSCC---------T---TSSC T ss_pred CEEEEecCHHHHHHHHHHHHHcCCC--CCEEEecccCCHHHh-cCCCchhhcCCEEEEecCCC---------C---CCCC Confidence 8887776666677888888887773 456665533221110 0000 11222221111000 0 0001 Q NP_000836.2 354 RRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPR 433 (908) Q Consensus 354 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~ 433 (908) +....|.+.+++.+.. .....++..+||++++++++++++.... T Consensus 289 ~~~~~f~~~~~~~~~~--------------------------~~~~~~~~~~yda~~~~~~al~~~~~~~---------- 332 (405) T 4N03_A 289 PAIKKLAEAYSKKYPK--------------------------DPLDSGVVNGYGGASIVVSALEKACANK---------- 332 (405) T ss_dssp HHHHHHHHHHHHHCTT--------------------------SCCCHHHHHHHHHHHHHHHHHHHHHHTT---------- T ss_pred HHHHHHHHHHHHHCCC--------------------------CCCChHHHHHHHHHHHHHHHHHHHHHCC---------- Confidence 1112222222222110 0113457789999999999999875311 Q NP_000836.2 434 MSTIDGKELLGYIRAV-NF-NGSAGTPVTFNENGDA-PGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 434 ~~~~~~~~l~~~l~~~-~f-~G~~G~~v~Fd~~G~~-~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ..+++.+.+.|++. .| .|.+| ++.|+.+|++ ...+.|++++..+ ...++.||.|... T Consensus 333 --~~~~~~l~~~l~~~~~~~~g~~g-~i~f~~~g~~~~~~~~i~~~~~~~-~~~~~~v~~~~~~ 392 (405) T 4N03_A 333 --DLTREGLINAHRSEANADDGLGT-PMNFTYFDKPATRKTYIIKPDEKA-TGGAVIVEQAFES 392 (405) T ss_dssp --EESHHHHHHHHTTCSCBCCSSSC-CBCCSCCSSCSCCCEEEEEECTTS-GGGEEEEEEEECC T ss_pred --CCCHHHHHHHHhcccCCCCCCCC-ccccccCCCCCcccEEEEEeCCCC-CCceEEEeeeecc Confidence 12455677788765 57 68888 8999988876 4578888886432 3468899999765 No 102 >4M88_A Extracellular ligand-binding receptor; STRUCTURAL GENOMICS, PSI-BIOLOGY, MIDWEST CENTER; HET: GOL; 1.762A {Verminephrobacter eiseniae} Probab=99.46 E-value=4.9e-18 Score=180.42 Aligned_cols=343 Identities=14% Similarity=0.064 Sum_probs=212.0 Template_Neff=12.000 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||++.|.++... ..+.....|++.|++++|+.+++. |+++++.+.|+.+++.. ..+.+++ T Consensus 2 ~~~i~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~g~~~-g~~i~~~~~d~~~~~~~----~~~~~~~ 66 (357) T 4M88_A 2 NAQIVLGQIGPFTGPLA----------ADAAGLNQGIKAYLAQANKAGGIR-GQKLTLFEADDRFSGEG----FAEQFPK 66 (357) T ss_dssp -CEEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHHTTCBT-TBEEEEEEEECTTSHHH----HHHHHHH T ss_pred CCeEEEeEEecCCCCCh----------HHhHHHHHHHHHHHHHHHHcCCCC-CEEeEEEEEcCCCCHHH----HHHHHHH Confidence 46789999999876421 245678899999999999876654 77888888887665432 3333443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVAN--ILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~--~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++. ++++++|++.++.....+.. .+...++|+|++....+.+.. ..+++++++.++.. T Consensus 67 ~~~-------------------~~v~~iig~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~-~~~~~~~~~~~~~~ 126 (357) T 4M88_A 67 AME-------------------KKPLALISPMGSAAIKRMLDDKLLDTAPVVVVNGVPGAESLRT-PGHPKFFHVRAGDK 126 (357) T ss_dssp HHT-------------------TCCSEEECCBCHHHHHHHHHTTTTSSCSCEEECCBSCCHHHHS-SCCTTEEBCSCCHH T ss_pred HHh-------------------hCCCEEEeCCCcHHHHHHcchhHHhcCCcEEEECCCCchhhcC-CCCCCeEEccCCcH Confidence 332 47889998877666555555 678889999988765544332 23577899999998 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISRE-IGGVCIAQ-SQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~-~~~i~v~~-~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ..++.+++++.+.+|+++++++.++.++..+.+.|++.+++ . ++.+.. ...+. .+..+....+++++. .++|+| T Consensus 127 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~-g~~i~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i 202 (357) T 4M88_A 127 QEIEEIVSHAQMLGMSKLATLYQDLPTGTSGMAVVQEAVKTVP-GGKIELNGVKSG--PDAAALAAAARQIAA-LGAQGV 202 (357) T ss_dssp HHHHHHHHHHHHTTCSEEEEEEESSHHHHHHHHHHHHHHHTCT-TCCCEEEEEEEC--SSHHHHHHHHHHHHT-TTCSEE T ss_pred HHHHHHHHHHHHhCCCEEEEEEeCChhcHHHHHHHHHHHHcCC-CCceEEEEeecC--CCHHHHHHHHHHHHH-cCCCEE Confidence 88999999988889999999997667787888888888776 4 344431 11111 122345556666663 578888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQE-EIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~-~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) ++...+..+..+++++++.|+. ..|++.+.+...... .... ....+.+....... .. ....+... T Consensus 203 i~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~--------~~---~~~~~~~~ 268 (357) T 4M88_A 203 LVIGPPPFIVAGIAALRKADVT--QPLFVLSYVSAAQIV-KVVGVAGARGVGIVQAFPD--------PN---DKMLPVQR 268 (357) T ss_dssp EEESSHHHHHHHHHHHHHTTCC--SCEEECTTCCHHHHH-HHHHHHHHTTEEEEESSSC--------TT---CCSSHHHH T ss_pred EEECCHHHHHHHHHHHHhCCCC--CCEEEeecCCHHHHH-HHHcccCcceEEEEEEeCC--------cc---cCCCHHHH Confidence 7777666677888998888874 345554433221110 0000 11122221110000 00 00011122 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTI 437 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~ 437 (908) .|.+.+++.++. ...+..++..+||+++++++|++++... .. T Consensus 269 ~f~~~~~~~~~~-------------------------~~~~~~~~~~~yda~~~~~~al~~~~~~-------------~~ 310 (357) T 4M88_A 269 EFQAAMKEAFPQ-------------------------MQEYTEFQLEGYLSARTVGEALKHPKNT-------------GL 310 (357) T ss_dssp HHHHHHHHHCTT-------------------------CCSCCHHHHHHHHHHHHHHHHHHSTTCC-------------CS T ss_pred HHHHHHHHHccc-------------------------cCCCChHHHHHHHHHHHHHHHHhccCCC-------------CC Confidence 233333322210 0112346788999999999999886421 12 Q NP_000836.2 438 DGKELLGYIRAV-NFNGSAGTPVTFNENGDAPGRYDIFQYQ 477 (908) Q Consensus 438 ~~~~l~~~l~~~-~f~G~~G~~v~Fd~~G~~~~~~~i~~~~ 477 (908) +++.+.++|++. .|. .+|.++.|+++|++...+.+.++. T Consensus 311 ~~~~l~~~l~~~~~~~-~~G~~~~f~~~~~~~~~~~i~~~~ 350 (357) T 4M88_A 311 SAANLAATLSTMGEID-IGGFHLDFSKGNAGSRYVNIGVIG 350 (357) T ss_dssp SHHHHHHHHHHSCCEE-ETTEEECCSSSSBCCCCCEEEEEC T ss_pred CHHHHHHHHHcCCCcc-cCcEEeecCCCCCccCcEEEEEEc Confidence 455677778765 465 334268999877766677777774 No 103 >3I09_B Periplasmic branched-chain amino acid-binding protein; TYPE I PERIPLASMIC BINDING PROTEIN; HET: MSE, CIT, EDO, AAE; 1.8A {Burkholderia mallei} Probab=99.45 E-value=6.2e-18 Score=181.03 Aligned_cols=347 Identities=10% Similarity=0.101 Sum_probs=213.9 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||+++|.++... ...+.....+++.|++++|. + +.|+++++.+.|+.+++. ...+.+++ T Consensus 2 ~~~~~Ig~i~~~~~~~~---------~~~~~~~~~g~~~a~~~~~~--~-~~g~~i~~~~~d~~~~~~----~~~~~~~~ 65 (375) T 3I09_B 2 ADSVKIGFITDMSGLYA---------DIDGQGGLEAIKMAVADFGG--K-VNGKPIEVVYADHQNKAD----IAASKARE 65 (375) T ss_dssp CSSEEEEEEECSSSTTT---------TTSHHHHHHHHHHHHHHHTS--E-ETTEEEEEEEEECTTCHH----HHHHHHHH T ss_pred CCeeEEEEEeCCCCcch---------hhcchhHHHHHHHHHHHhCC--c-cCCEEEEEEEecCCCCHH----HHHHHHHH Confidence 46789999999875421 01356778899999999872 2 346778888888765533 22333444 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++++++|++.++.....+...+...++|+|.+....+.+.....+++++++.+++... T Consensus 66 l~~------------------~~~v~~vi~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 127 (375) T 3I09_B 66 WMD------------------RGGLDLLVGGTNSATALSMNQVAAEKKKVYINIGAGADTLTNEQCTPYTVHYAYDTMAL 127 (375) T ss_dssp HHH------------------HSCEEEEEECSCHHHHHHHHHHHHHHTCEEEECSCCCGGGGTTTCCTTEEECSCCHHHH T ss_pred HHH------------------hCCCCEEEecCChHHHHHHHHHHHHcCCEEEEccCCccccCCCcCCCceeEecCCHhHH Confidence 332 15788999977766666667778889999999876655433222346778888888888 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) ++.+++++.+.+|+++++++.++.++..+.+.+.+.+++. ++++.....+. .+..++...++++.. .++|++++.. T Consensus 128 ~~~~~~~l~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~~~ 203 (375) T 3I09_B 128 AKGTGSAVVKQGGKTWFFLTADYAFGKALEKNTADVVKAN-GGKVLGEVRHP--LSASDFSSFLLQAQS-SKAQILGLAN 203 (375) T ss_dssp CCCCCHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCSCCHHHHHHHHH-TTCSEEEEEC T ss_pred HHHHHHHHHHcCCCEEEEEEeCcHHHHHHHHHHHHHHHHC-CCEEEEEEeCC--CCccchHHHHHHHHh-cCCCEEEEEe Confidence 8899998877899999999976667778888888888775 35544322222 122345556666653 4788887776 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQ-EEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAE 361 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~-~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 361 (908) .+..+..+++++++.|+...+ ++.......... ... .....+.+.... +.. ...+....|.+ T Consensus 204 ~~~~~~~~~~~l~~~g~~~~~-~~~~~~~~~~~~--~~~~~~~~~~~~~~~~----------~~~----~~~~~~~~f~~ 266 (375) T 3I09_B 204 AGGDTVNAIKAAKEFGITKTM-KLAALLMFINDV--HALGLETTQGLVLTDS----------WYW----NRDQASRQWAQ 266 (375) T ss_dssp CHHHHHHHHHHHHHTTGGGTC-EEEESSCCHHHH--HHHCHHHHTTCEEEES----------CCT----TSSHHHHHHHH T ss_pred cchHHHHHHHHHHHcCCCCCe-eEeeccccHHHH--HHcCHhHHcCceEeec----------ccc----CCCHHHHHHHH Confidence 666778899999888875322 232211111000 000 011122211110 000 00111122333 Q NP_000836.2 362 FWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKE 441 (908) Q Consensus 362 ~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~ 441 (908) .+++.++ ..++.++..+|||++++++|++++.. .++.. T Consensus 267 ~~~~~~~---------------------------~~p~~~~~~~yda~~~~~~al~~~~~---------------~~~~~ 304 (375) T 3I09_B 267 RYFAKMK---------------------------KMPSSLQAADYSSVTTYLKAVQAAGS---------------TDSDK 304 (375) T ss_dssp HHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHTS---------------CCHHH T ss_pred HHHHHHC---------------------------CCCCHHHHHHHHHHHHHHHHHHHhCC---------------CCHHH Confidence 2322221 11235677899999999999988642 13456 Q NP_000836.2 442 LLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 442 l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) +.++|++..|.|.+| .+.|+.+|++...+.+.+++.+ . ..+|.|. T Consensus 305 ~~~~l~~~~~~~~~~-~~~~~~~g~~~~~~~i~~~~~~----~-~~~~~~~ 349 (375) T 3I09_B 305 VMAQLKKMKIDDFYA-KGYIRTDGSMIHDMYLMEVKKP----S-ESKEPWD 349 (375) T ss_dssp HHHHHTTSCEESSSC-EEEECTTSBEECCEEEEEECCG----G-GCCSTTC T ss_pred HHHHHhcCCccccCC-ceEEecCCCeEeeEEEEEEeCC----C-CCCCCcc Confidence 778888777877555 6777777877777888887631 1 4555565 No 104 >5TQ0_B NMDA glutamate receptor subunit, Glutamate; ION CHANNEL, NMDA RECEPTOR, ALLOSTERIC; HET: GOL, NAG, SO4; 2.7A {Mus musculus} Probab=99.45 E-value=6.5e-18 Score=179.74 Aligned_cols=343 Identities=16% Similarity=0.212 Sum_probs=207.3 Template_Neff=11.700 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVR---ILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~---~~d~~~~~~~a~~~~~~~~~~ 122 (908) ++||+++|.++.. +.+.|++++|+. .++|+++++. +.|+.+++..+. +.+++ T Consensus 1 i~ig~i~~~sg~~-------------------~~~~~~~~~n~~--~~~~~~v~l~~~~~~d~~~~~~~~~----~~~~~ 55 (360) T 5TQ0_B 1 LNIAVLLGHSHDV-------------------TERELRNLWGPE--QATGLPLDVNVVALLMNRTDPKSLI----THVCD 55 (360) T ss_dssp CEEEEEECSSSCC-------------------CCCCC--------------CSCCEEEEEECSCCSHHHHH----HHHHH T ss_pred CeEEEEecCCCCh-------------------hHHHHHHccCcc--ccCCCCcEEEEEEeecCCCCHHHHH----HHHHH Confidence 5799999987631 235577788864 2457777774 477766644333 33333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKI-SGVIGAAASSVS--IMVANILRLFKIPQISYASTAPELSD-NTRYDFFSRVVPP 198 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v-~~vIg~~~s~~~--~~va~~~~~~~iP~Is~~~~~~~l~~-~~~~~~~~~~~~~ 198 (908) ++.. +++ ++++|+.++..+ ..++.++...++|+|++.+..+.+.. ...+++++++.|+ T Consensus 56 l~~~------------------~~v~~~vig~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~ 117 (360) T 5TQ0_B 56 LMSG------------------ARIHGLVFGDDTDQEAVAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGAS 117 (360) T ss_dssp HHHT------------------TCCSEEEEECCSCCTHHHHHHHHHHHHHCCCEEEEEGGGGCCCSCCCTTCCEEESCCC T ss_pred HHcC------------------CCceEEEEcCCCChHHHHHHHHHHHhhcCCCEEEecCCCcccccCCCCCCceEeecCC Confidence 3321 456 678898877665 67788889999999998876654432 2247899999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ...+++++++++.+++|+++++++.++.++....+.+++.+++.+ ++++.....++ ....++. .+++++. .++++ T Consensus 118 ~~~~~~~l~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~~~~~--~~~~~~~-~~~~i~~-~~~~~ 193 (360) T 5TQ0_B 118 IQQQATVMLKIMQDYDWHVFSLVTTIFPGYRDFISFIKTTVDNSFVGWDMQNVITLD--TSFEDAK-TQVQLKK-IHSSV 193 (360) T ss_dssp HHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHSSSCCEECCCEEES--CSSCTHH-HHHHHTT-CCCSE T ss_pred HHHHHHHHHHHHHHcCCeEEEEEEecCCchHHHHHHHHHHHhcCCCcceeEEEEEec--CCcccHH-HHHHHhc-CCCeE Confidence 988899999999888999999999887788877788887776542 13443322232 1223455 6666663 57888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) |++.........+++++++.|+.. .+.|+..+.+...... .......+.+. T Consensus 194 vv~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~~-------------------------- 245 (360) T 5TQ0_B 194 ILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTEL--IPKEFPSGLIS-------------------------- 245 (360) T ss_dssp EEEECCHHHHHHHHHHHHHTTCSSTTSEEEECHHHHCSTTC--CCTTSCTTCEE-------------------------- T ss_pred EEEEcCHHHHHHHHHHHHHcCCCCCCEEEEeecccCCCCcC--CCccCCCceEE-------------------------- Confidence 888777777888999988888753 3567765433221100 00000001000 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP--GYIGLCPRM 434 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~--~~~~~~~~~ 434 (908) + . +. .+ ...++..+|||++++++|++++....+. .....|... T Consensus 246 --~-~-~~-~~------------------------------~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~c~~~ 290 (360) T 5TQ0_B 246 --V-S-YD-DW------------------------------DYSLEARVRDGLGILTTAASSMLEKFSYIPEAKASCYGQ 290 (360) T ss_dssp --E-E-SC-CS------------------------------SSCHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCSCSSCC T ss_pred --E-E-ec-Cc------------------------------cccHHHHHHHHHHHHHHHHHHHHHhcCCCCccccccccc Confidence 0 0 00 00 0124567999999999999987543210 001223211 Q NP_000836.2 435 ---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 ---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ....+..+.+.|++..|.|. .+.||++|++. ..+.+++++. ...++.||.|+... +....+.|+ T Consensus 291 ~~~~~~~~~~l~~~l~~~~~~G~---~i~f~~~g~~~~~~~~i~~~~~---~~~~~~vg~w~~~~-l~~~~~~w~ 358 (360) T 5TQ0_B 291 AEKPETPLHTLHQFMVNVTWDGK---DLSFTEEGYQVHPRLVVIVLNK---DREWEKVGKWENQT-LSLRHAVWP 358 (360) T ss_dssp -----CCSCCSTTTSSSCEETTE---ECCBCTTSSBSSCCCEEEEECT---TSCEEEEEECTTTT-CCBCCC--- T ss_pred CCCCCChHHHHHHHHcceeEcCe---eeEECCCCceeceEEEEEEeeC---CCceEEEEEEECCe-eEecceecC Confidence 11245567788888888875 69999999885 6788888873 15789999998762 322335563 No 105 >5TPW_B NMDA glutamate receptor subunit, Glutamate; ION CHANNEL, NMDA RECEPTOR, ALLOSTERIC; HET: NAG, GOL, SO4; 2.909A {Mus musculus} Probab=99.45 E-value=6.5e-18 Score=179.74 Aligned_cols=343 Identities=16% Similarity=0.212 Sum_probs=203.3 Template_Neff=11.700 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVR---ILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~---~~d~~~~~~~a~~~~~~~~~~ 122 (908) ++||+++|.++.. +.+.|++++|+. .++|+++++. +.|+.+++..+. +.+++ T Consensus 1 i~ig~i~~~sg~~-------------------~~~~~~~~~n~~--~~~~~~v~l~~~~~~d~~~~~~~~~----~~~~~ 55 (360) T 5TPW_B 1 LNIAVLLGHSHDV-------------------TERELRNLWGPE--QATGLPLDVNVVALLMNRTDPKSLI----THVCD 55 (360) T ss_dssp CEEEEEECSTTCC-------------------CC-------------------CCEEEEEECCCCSHHHHH----HHHHH T ss_pred CeEEEEecCCCCh-------------------hHHHHHHccCcc--ccCCCCcEEEEEEeecCCCCHHHHH----HHHHH Confidence 5799999987631 235577788864 2457777774 477766644333 33333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKI-SGVIGAAASSVS--IMVANILRLFKIPQISYASTAPELSD-NTRYDFFSRVVPP 198 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v-~~vIg~~~s~~~--~~va~~~~~~~iP~Is~~~~~~~l~~-~~~~~~~~~~~~~ 198 (908) ++.. +++ ++++|+.++..+ ..++.++...++|+|++.+..+.+.. ...+++++++.|+ T Consensus 56 l~~~------------------~~v~~~vig~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~ 117 (360) T 5TPW_B 56 LMSG------------------ARIHGLVFGDDTDQEAVAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGAS 117 (360) T ss_dssp HHTT------------------SCCSEEEEECSSCCTHHHHHHHHHHHHHCCCEEEEEGGGGCCCSCCCTTCCEEESCCC T ss_pred HHcC------------------CCceEEEEcCCCChHHHHHHHHHHHhhcCCCEEEecCCCcccccCCCCCCceEeecCC Confidence 3321 456 678898877665 67788889999999998876654432 2247899999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ...+++++++++.+++|+++++++.++.++....+.+++.+++.+ ++++.....++ ....++. .+++++. .++++ T Consensus 118 ~~~~~~~l~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~~~~~--~~~~~~~-~~~~i~~-~~~~~ 193 (360) T 5TPW_B 118 IQQQATVMLKIMQDYDWHVFSLVTTIFPGYRDFISFIKTTVDNSFVGWDMQNVITLD--TSFEDAK-TQVQLKK-IHSSV 193 (360) T ss_dssp HHHHHHHHHHHHHHTTCCEEEEEECSSTTHHHHHHHHHHHHHTSTTCSEECCCEECC--TTSCHHH-HHHHHTT-CCCSE T ss_pred HHHHHHHHHHHHHHcCCeEEEEEEecCCchHHHHHHHHHHHhcCCCcceeEEEEEec--CCcccHH-HHHHHhc-CCCeE Confidence 988899999999888999999999887788877788887776542 13443322232 1223455 6666663 57888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) |++.........+++++++.|+.. .+.|+..+.+...... .......+.+. T Consensus 194 vv~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~~-------------------------- 245 (360) T 5TPW_B 194 ILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTEL--IPKEFPSGLIS-------------------------- 245 (360) T ss_dssp EEEESCHHHHHHHHHHHHHTTCSSTTSEEEECHHHHCCSSC--CCTTSCTTCEE-------------------------- T ss_pred EEEEcCHHHHHHHHHHHHHcCCCCCCEEEEeecccCCCCcC--CCccCCCceEE-------------------------- Confidence 888777777888999988888753 3567765433221100 00000001000 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP--GYIGLCPRM 434 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~--~~~~~~~~~ 434 (908) + . +. .+ ...++..+|||++++++|++++....+. .....|... T Consensus 246 --~-~-~~-~~------------------------------~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~c~~~ 290 (360) T 5TPW_B 246 --V-S-YD-DW------------------------------DYSLEARVRDGLGILTTAASSMLEKFSYIPEAKASCYGQ 290 (360) T ss_dssp --E-E-SC-CT------------------------------TSCHHHHHHHHHHHHHHHHHHTTTSSSSCCCCCSCSCC- T ss_pred --E-E-ec-Cc------------------------------cccHHHHHHHHHHHHHHHHHHHHHhcCCCCccccccccc Confidence 0 0 00 00 0124567999999999999987543210 001223211 Q NP_000836.2 435 ---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 ---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ....+..+.+.|++..|.|. .+.||++|++. ..+.+++++. ...++.||.|+... +....+.|+ T Consensus 291 ~~~~~~~~~~l~~~l~~~~~~G~---~i~f~~~g~~~~~~~~i~~~~~---~~~~~~vg~w~~~~-l~~~~~~w~ 358 (360) T 5TPW_B 291 AEKPETPLHTLHQFMVNVTWDGK---DLSFTEEGYQVHPRLVVIVLNK---DREWEKVGKWENQT-LSLRHAVWP 358 (360) T ss_dssp -----CCSCCSSTTTSSCEETTE---ECCBCTTSSBSSCCCEEEEEET---TTEEEEEEECTTTT-CCCCC---- T ss_pred CCCCCChHHHHHHHHcceeEcCe---eeEECCCCceeceEEEEEEeeC---CCceEEEEEEECCe-eEecceecC Confidence 11245567788888888875 69999999885 6788888873 15789999998762 322335563 No 106 >4MAA_A Putative branched-chain amino acid ABC; Psi-Biology, MCSG, Midwest Center For; HET: GOL; 2.0A {Pseudomonas protegens} Probab=99.44 E-value=9.1e-18 Score=181.66 Aligned_cols=352 Identities=13% Similarity=0.078 Sum_probs=215.8 Template_Neff=12.000 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.++... ..+.....|++.|++++|.. .|.++++.+.|+.+++.. ..+. T Consensus 29 ~~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~~~----~g~~i~~~~~d~~~~~~~----~~~~ 90 (403) T 4MAA_A 29 AFAAEPFTFYGLKSMSGAFA----------SYGKFADMGSRLAVEQYPTL----LGRPLHYKVIDTEGNAGK----AVRR 90 (403) T ss_dssp -CCCCCEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHTCSEE----TTEEEEEEEEECTTCHHH----HHHH T ss_pred hhhCCCEEEEEEecCCCCch----------hhhHHHHHHHHHHHHhcCcc----CCeeeEEEEEeCCCCHHH----HHHH Confidence 45678999999999875321 25667889999999999842 366788888887655432 3333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV-PP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~-~~ 198 (908) +++++. .++++++|++.++.....+...+...++|+|.+.. .+.+.....+++++++. ++ T Consensus 91 ~~~l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~-~~~~~~~~~~~~~~~~~~~~ 151 (403) T 4MAA_A 91 VQEAIA------------------QDGARFFQGCTLSSSALAVAKEVGKVGGVFMTPVG-ADEITGKDCNASTFRWSVPT 151 (403) T ss_dssp HHHHHH------------------HHCCCEEEECSSHHHHHHHHHHHHHHTCEEEECCC-CGGGGTTTCCTTEEECSCCH T ss_pred HHHHHH------------------hcCCCEEEecCCcHHHHHHHHHHHhhCCEEEccCC-ccccCCCCCCCceeEeeCCc Confidence 444332 15788999987776666777778889999998875 33222211256777875 66 Q NP_000836.2 199 DSYQAQAMVDIVTA-LGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 199 ~~~~~~~~~~~l~~-~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ....++.+++++.+ .+|++|++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++|+ T Consensus 152 ~~~~~~~~~~~l~~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~d~ 227 (403) T 4MAA_A 152 YGAIRETMVPLIKLLPEAKRWYTITPQYVFGEALLEGAKQVCAEH-GIEHIGNSYHS--LQEQEFSGYLTNAIA-ARPDV 227 (403) T ss_dssp HHHHHHHHHHHHHHCTTCCEEEEEEESSHHHHHHHHHHHHHHHHH-TCEEEEEEEEC--TTCCCCHHHHHHHHH-HCCSE T ss_pred HHHHHHhhHHHHHhCCCCCEEEEEEeCCHHHHHHHHHHHHHHHHC-CCEEEEEEEec--CCCCChHHHHHHHHH-hCCCE Confidence 66677788888866 589999999976677778888888888765 35544332222 122345556666653 57888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) +++...+..+..+++++++.|+..++.+++.+....... .........+.+..... +.. ...+... T Consensus 228 v~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~~~---~~~~~~~ 293 (403) T 4MAA_A 228 LVLLNFGSQSSNALRQAVNFGIKERMKVLLVWSAGLDQF-QELGSDVLEGVYLGAQY----------WHQ---VDTPLNR 293 (403) T ss_dssp EEECCCHHHHHHHHHHHHHHTHHHHSEEEESSCCTHHHH-HHHHHHHHBTCEEEESC----------CTT---CCCHHHH T ss_pred EEEECCchHHHHHHHHHHHCCCccCcEEEEeccccHHHH-HHHchhhhcCcEEEecc----------ccc---CCCHHHH Confidence 877765566778888888888753333444322111100 00000112222211100 000 0011112 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTI 437 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~ 437 (908) .|.+.+++.++ ..++.++..+||++++++++++++.. . T Consensus 294 ~f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~---------------~ 331 (403) T 4MAA_A 294 ELVKLTQAKYG---------------------------INPTYPLAADYIGSKIILDTIAATGS---------------F 331 (403) T ss_dssp HHHHHHHHHTS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHTC---------------C T ss_pred HHHHHHHHHHC---------------------------CCCChhHHHHHHHHHHHHHHHHHHCC---------------C Confidence 23333322221 11234567899999999999988642 2 Q NP_000836.2 438 DGKELLGYIRAVNFNGSAGTPVTFNE-NGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 438 ~~~~l~~~l~~~~f~G~~G~~v~Fd~-~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ++..+.++|++..|.|.+| .+.||+ +++....+.+++++. .. ..+|.|+.. T Consensus 332 ~~~~l~~~l~~~~~~g~~g-~~~f~~~~~~~~~~~~i~~~~~----~~-~~~~~w~~~ 383 (403) T 4MAA_A 332 DGATVAKAMQGLTYQGPTG-EESIRAGDHQVIKDYYLLVGKA----AA-TMRDKDDLA 383 (403) T ss_dssp CHHHHHHHHTTCEEEETTE-EEEECTTTCBEECCEEEEEECC----GG-GCSSTTCCE T ss_pred CHHHHHHHHcCCceecCCe-eEEeCCCCCeeeeeEEEEEeec----cc-ccCCHhHHH Confidence 3456778888888999988 899997 334445677777762 22 567888755 No 107 >5L1B_D Glutamate receptor 2; Transporter, fusion protein, MEMBRANE PROTEIN; HET: NAG; 4.0A {Rattus norvegicus} Probab=99.43 E-value=1.1e-17 Score=198.82 Aligned_cols=356 Identities=15% Similarity=0.203 Sum_probs=224.6 Template_Neff=11.600 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~~~~ 122 (908) ++++||++.|.++. ....|++.|++++|++ |+++++.+.|+. +++. .+.+.+++ T Consensus 1 ~~i~Ig~~~~~~~~----------------~~~~g~~~a~~~in~~-----g~~i~~~~~d~~~~~~~----~~~~~~~~ 55 (803) T 5L1B_D 1 NSIQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSF----AVTNAFCS 55 (803) T ss_dssp CEEEEEEEEESSCS----------------HHHHHHHHHHHHTCCS-----SCEEEEEEEEECTTCHH----HHHHHHHH T ss_pred CceeeEeeeCCCCh----------------HHHHHHHHHHHhhcCC-----CceeeeeeEecCCCCHH----HHHHHHHH Confidence 36889999998752 4668999999999975 467888888865 3332 22233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) +.. +++++++|+.++..+..++.++...++|++++..+++ ..+++++++.++ . T Consensus 56 l~~-------------------~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~---~ 108 (803) T 5L1B_D 56 QFS-------------------RGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPD---L 108 (803) T ss_dssp HHH-------------------TTCSEEECCCCTTTHHHHHHHHHHSCCEEEECSCCCS-----SCCSSEEECSCC---C T ss_pred HHh-------------------cCeeEEEecCChHHHHHHHHHHcccCCcEEeCCCCCC-----CCCCeEEEecCC---h Confidence 332 5789999998887777888888899999998876443 247889999988 5 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPR--EPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ++++++++++++|+++++++ +++++....+.+.+.+++. ++++.....++. +.+..++...++++++ .++++|++ T Consensus 109 ~~~~~~~l~~~~~~~v~ii~-~~~~~~~~~~~~~~~~~~~-~~~i~~~~~~~~~~~~~~~d~~~~~~~i~~-~~~~~i~~ 185 (803) T 5L1B_D 109 KGALLSLIEYYQWDKFAYLY-DSDRGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKERRVIL 185 (803) T ss_dssp HHHHHHHHHHTTCSEEEEEE-CSTTCSHHHHHHHHHHHHH-TCEEEEEECSCCCSSSHHHHHHHHHHHHGG-GTCCCEEE T ss_pred HHHHHHHHHHhCCCEEEEEE-eCcchHHHHHHHHHHHhhc-CCeEEEEEccCCCCCCCcchhHHHHHHHHh-cCCeEEEE Confidence 77888888888999999999 5567777777777777664 355544322210 0122456677777763 57899888 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) .+....+..+++++++.|+.. .+.|++.+.+...... ........+...... .. ...+....+ T Consensus 186 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~-----------~~----~~~~~~~~f 249 (803) T 5L1B_D 186 DCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGAEVSGFQI-----------VD----YDDSLVSKF 249 (803) T ss_dssp ESCHHHHHHHHHHHHHTTCCBTTCEEEECSSBTTTSCC-SSSSSSBCEEEEEEC-----------SC----SSSHHHHHH T ss_pred ECCHHHHHHHHHHHHHcCCCCCCcEEEEEeCCCCccch-hhcccCCeeEEEEEE-----------Ee----CCchHHHHH Confidence 877777888999999888754 3567765432211100 000000111111100 00 011112233 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~~~~- 434 (908) .+.+++.+++. +... ....+..++..+|||++++++|++++...... .....|... T Consensus 250 ~~~~~~~~~~~-------------~~~~------~~~~~~~~~~~~yda~~~~a~al~~~~~~~~~~~~~~~~~~~~~~~ 310 (803) T 5L1B_D 250 IERWSTLEEKE-------------YPGA------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANP 310 (803) T ss_dssp HHHHTTSCTTT-------------STTC------SSSCCCHHHHHHHHHHHHHHHHHHHHHHTTCCCCCSSCCCCTTCSS T ss_pred HHHHHhcchhh-------------CCCc------ccCCCchHHHHHHHHHHHHHHHHHHHHHhccccccCCCCCCcccCC Confidence 33343332210 0000 00123456788999999999999988653210 000122110 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ...+++.+.+.|++..|.|.+| ++.|+++|++.. .+.+++++ ++.++.+|.|+.. T Consensus 311 ~~~~~~~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~~i~~~~----~~~~~~~~~~~~~ 368 (803) T 5L1B_D 311 AVPWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEV 368 (803) T ss_dssp CCCCTHHHHHHHHHTTCCCEETTE-ECEECSSCCEESCCEEEEEEC----SSSEEEEEEEETT T ss_pred CCCccccHHHHHHHHhcCccCCCc-cEEECCCCcEEEEEEEEEEec----cCCceEEEEEecC Confidence 1124567888888889999988 899999898764 78888887 2467888888854 No 108 >4TLL_D GluN1/GluN2B; Neurotransmitter receptor, NMDA receptor, GluN1/GluN2B; HET: QEM, JEG, NAG; 3.59A {Xenopus laevis} Probab=99.42 E-value=1.3e-17 Score=198.99 Aligned_cols=340 Identities=15% Similarity=0.200 Sum_probs=214.1 Template_Neff=11.400 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPD--LLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~--il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ...+++++||+++|.++ . ++|++++|++++ ++++..+.+...|+.+++..+.+. T Consensus 5 ~~~~~~i~Ig~~~p~sg--------------~--------~~a~~~~n~~~~~~~~~~~~~~~~~~d~~~~~~~~~~~-- 60 (824) T 4TLL_D 5 AQKHPNMDIAVILVGTT--------------E--------EVAIKDVHEKDDFHHLPVTPRVELVTMQESDPKSIITR-- 60 (824) T ss_dssp ---CCEEEEEEEEECCS--------------S--------CCCTTC-------CCCSSEEEEEEEEESCCCHHHHHHH-- T ss_pred cccCCCceEEEEEcCCC--------------h--------HHhhhccccCCCcccCCCCceeEEEeCCCCCHHHHHHH-- Confidence 45567899999999763 1 889999998876 455665667777777665443333 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVI-GAAASS--VSIMVANILRLFKIPQISYASTAPE-LSDNTRYDFFS 193 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~--~~~~va~~~~~~~iP~Is~~~~~~~-l~~~~~~~~~~ 193 (908) +.+++. ++++++++ |+.++. ....++..+...++|++++....+. +++...+++++ T Consensus 61 --~~~l~~------------------~~~v~~vv~G~~~s~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~ 120 (824) T 4TLL_D 61 --ICDLMS------------------DKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFF 120 (824) T ss_dssp --HHHHHT------------------TTCEEEEEEECCCCCTHHHHHHHHHHHHHTCCEEECSGGGGSCCSCCCTTCCEE T ss_pred --HHHHhc------------------cCCCEEEEEcCCCChHHHHHHHHHHHHhhCCCEEEecCCCccccccccccceEE Confidence 333332 15789987 988776 4456677778899999986554432 22233578999 Q NP_000836.2 194 RVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREP-RPGEFEKIIKRLLET 272 (908) Q Consensus 194 ~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~ 272 (908) ++.+++..+++++++++++++|+++++++.+++++....+.+++.+++. ++++.......... ...+....++++++ T Consensus 121 ~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~~~- 198 (824) T 4TLL_D 121 QFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRSTIENS-FVGWELEEVIHLDMSLDDIDSKIQNQLCK- 198 (824) T ss_dssp ESSBCHHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHC-CBCCEEEEEEEECTTSCCSSCHHHHHHTT- T ss_pred ecCCCHHHHHHHHHHHHHHcCCeEEEEEEEcCCChHHHHHHHHHHHHhc-cCCcEEEEEEEecCChhhhhHHHHHHHHh- Confidence 9999999999999999988899999999988888888888888877764 34433221111101 11223444555653 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLA 351 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~ 351 (908) .++|+|++......+..+++++++.|+.+ .+.|+..+.|...... .......+.+ T Consensus 199 ~~~~~iv~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~---------------------- 254 (824) T 4TLL_D 199 LQSPVILLYCTKEEATYIFEVAHSVGLTGYGFTWIVPSLVAGDTDT--VPDEFPTGLI---------------------- 254 (824) T ss_dssp CCSSEEEEECCHHHHHHHHHHHHHHTTTSTTCEEECCTTTCCCSSC--CCTTSCTTCE---------------------- T ss_pred cCCCEEEEECCHHHHHHHHHHHHHcCCCCCCeEEEeeccCCCCCCC--CCCcCCCCee---------------------- Confidence 57899888877777888999999888754 4567765533221100 0000000000 Q NP_000836.2 352 NNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG--YIG 429 (908) Q Consensus 352 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~--~~~ 429 (908) ...+. ..+..+++.+|||++++++|+++.....+.. ... T Consensus 255 ------------~~~~~---------------------------~~~~~~~~~~Ydav~ll~~a~~~~~~~~~~~~~~~~ 295 (824) T 4TLL_D 255 ------------SVSYD---------------------------EWDYDLPARVRDGIAIITTAASTMLSEHNSIPQSKS 295 (824) T ss_dssp ------------EEEEC---------------------------SSSSCHHHHHHHHHHHHHHHHHHHHHHSCC---CCC T ss_pred ------------EEEee---------------------------cCCCCcchhHHHHHHHHHHHHHHHHHhcCCCCCCcc Confidence 00000 0112356789999999999999886542210 011 Q NP_000836.2 430 LCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDA-PGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 430 ~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~-~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .|... ...++..+.+++++.+|.| | ++.||++|++ ...+.+++++. ++.++.+|.|+.. T Consensus 296 ~~~~~~~~~~~~~~~l~~~l~~~~f~g--G-~~~f~~~g~~~~~~~~i~~~~~---~g~~~~v~~~~~~ 358 (824) T 4TLL_D 296 SCNNIQESRVYEAHMLKRYLINVTFEG--R-DLSFSEDGYQMHPKLVIILLNQ---ERKWERVGKYKDR 358 (824) T ss_dssp CSSCCTTCCHHHHHHHHHHHHCCEETT--E-ECCBCTTSSBSSCCEEEEEECT---TSCEEEEEEECSS T ss_pred cccccccccceeHHHHHHHHhcCccCC--c-eeeeCCCCccceeeEEEEEecC---CcceEEEEEEECc Confidence 22211 1124567888888889988 7 8999999987 46788888873 3578899998764 No 109 >4TLM_D GluN1/GluN2B; neurotransmitter receptor, NMDA receptor, GluN1/GluN2B; HET: NAG, QEM, JEG; 3.77A {Xenopus laevis} Probab=99.42 E-value=1.3e-17 Score=198.99 Aligned_cols=340 Identities=15% Similarity=0.200 Sum_probs=216.8 Template_Neff=11.400 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPD--LLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~--il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ...+++++||+++|.++ . ++|++++|++++ ++++..+.+...|+.+++..+.+. T Consensus 5 ~~~~~~i~Ig~~~p~sg--------------~--------~~a~~~~n~~~~~~~~~~~~~~~~~~d~~~~~~~~~~~-- 60 (824) T 4TLM_D 5 AQKHPNMDIAVILVGTT--------------E--------EVAIKDVHEKDDFHHLPVTPRVELVTMQESDPKSIITR-- 60 (824) T ss_dssp ------CEEEEEEECTT--------------C--------CCTHHHHHHTTTTTTSSSCCEEEEEEESSCCHHHHHHH-- T ss_pred cccCCCceEEEEEcCCC--------------h--------HHhhhccccCCCcccCCCCceeEEEeCCCCCHHHHHHH-- Confidence 45567899999999763 1 889999998876 455665667777777665443333 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVI-GAAASS--VSIMVANILRLFKIPQISYASTAPE-LSDNTRYDFFS 193 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~--~~~~va~~~~~~~iP~Is~~~~~~~-l~~~~~~~~~~ 193 (908) +.+++. ++++++++ |+.++. ....++..+...++|++++....+. +++...+++++ T Consensus 61 --~~~l~~------------------~~~v~~vv~G~~~s~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~ 120 (824) T 4TLM_D 61 --ICDLMS------------------DKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFF 120 (824) T ss_dssp --HHHHHH------------------HHCCSEEEEEESCCCSHHHHHHHHHHHHHCCCEEECSHHHHSCCSCCCSSSCEE T ss_pred --HHHHhc------------------cCCCEEEEEcCCCChHHHHHHHHHHHHhhCCCEEEecCCCccccccccccceEE Confidence 333332 15789987 988776 4456677778899999986554432 22233578999 Q NP_000836.2 194 RVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREP-RPGEFEKIIKRLLET 272 (908) Q Consensus 194 ~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~ 272 (908) ++.+++..+++++++++++++|+++++++.+++++....+.+++.+++. ++++.......... ...+....++++++ T Consensus 121 ~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~~~- 198 (824) T 4TLM_D 121 QFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRSTIENS-FVGWELEEVIHLDMSLDDIDSKIQNQLCK- 198 (824) T ss_dssp ESSCCHHHHHHHHHHHHHHTTCCEEEEEEESSTTTTHHHHHHHHHHHHS-SSCCEEEEEEEECSSSCCSSCHHHHHHTT- T ss_pred ecCCCHHHHHHHHHHHHHHcCCeEEEEEEEcCCChHHHHHHHHHHHHhc-cCCcEEEEEEEecCChhhhhHHHHHHHHh- Confidence 9999999999999999988899999999988888888888888877764 34433221111101 11223444555653 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLA 351 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~ 351 (908) .++|+|++......+..+++++++.|+.+ .+.|+..+.|...... .......+.+ T Consensus 199 ~~~~~iv~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~---------------------- 254 (824) T 4TLM_D 199 LQSPVILLYCTKEEATYIFEVAHSVGLTGYGFTWIVPSLVAGDTDT--VPDEFPTGLI---------------------- 254 (824) T ss_dssp CCCSEEEEESCHHHHHHHHHHHHHHTTTSTTCEEEECHHHHTTSSC--CCTTSCTTCE---------------------- T ss_pred cCCCEEEEECCHHHHHHHHHHHHHcCCCCCCeEEEeeccCCCCCCC--CCCcCCCCee---------------------- Confidence 57899888877777888999999888754 4567765533221100 0000000000 Q NP_000836.2 352 NNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG--YIG 429 (908) Q Consensus 352 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~--~~~ 429 (908) ...+. ..+..+++.+|||++++++|+++.....+.. ... T Consensus 255 ------------~~~~~---------------------------~~~~~~~~~~Ydav~ll~~a~~~~~~~~~~~~~~~~ 295 (824) T 4TLM_D 255 ------------SVSYD---------------------------EWDYDLPARVRDGIAIITTAASTMLSEHNSIPQSKS 295 (824) T ss_dssp ------------EEECC---------------------------TTTCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC T ss_pred ------------EEEee---------------------------cCCCCcchhHHHHHHHHHHHHHHHHHhcCCCCCCcc Confidence 00000 0112356789999999999999886542210 011 Q NP_000836.2 430 LCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDA-PGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 430 ~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~-~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .|... ...++..+.+++++.+|.| | ++.||++|++ ...+.+++++. ++.++.+|.|+.. T Consensus 296 ~~~~~~~~~~~~~~~l~~~l~~~~f~g--G-~~~f~~~g~~~~~~~~i~~~~~---~g~~~~v~~~~~~ 358 (824) T 4TLM_D 296 SCNNIQESRVYEAHMLKRYLINVTFEG--R-DLSFSEDGYQMHPKLVIILLNQ---ERKWERVGKYKDR 358 (824) T ss_dssp CSSSCCCTTCTTHHHHHHHHTSCEETT--E-ECCBCTTSBBSCCCEEEEEECS---TTCEEEEEEEETT T ss_pred cccccccccceeHHHHHHHHhcCccCC--c-eeeeCCCCccceeeEEEEEecC---CcceEEEEEEECc Confidence 22211 1124567888888889988 7 8999999987 46788888873 3578899998764 No 110 >4EYQ_A Extracellular ligand-binding receptor; PSI-BIOLOGY, MCSG, MIDWEST CENTER FOR; HET: DHC, MSE, ENO; 1.96A {Rhodopseudomonas palustris} Probab=99.41 E-value=1.8e-17 Score=176.21 Aligned_cols=348 Identities=13% Similarity=0.160 Sum_probs=206.9 Template_Neff=12.200 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||+++|..+... ..+.....+++.|++++| |+++++.+.|+.+++.. ..+.+ T Consensus 3 ~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~~~~~a~~~~~-------g~~i~~~~~d~~~~~~~----~~~~~ 61 (362) T 4EYQ_A 3 AETNEITVGITVTTTGPAA----------ALGIPERNALEFVAKEIG-------GHPIKMIVLDDGGDPTA----ATTNA 61 (362) T ss_dssp CCCSSEEEEEEECCSSTTH----------HHHHHHHHHGGGSCSEET-------TEEEEEEEEECTTCHHH----HHHHH T ss_pred ccCCcEEEEEEEeCCCccH----------HhCccHHHHHHHHHHHhC-------CEEEEEEEEeCCCCHHH----HHHHH Confidence 3456899999999875321 245677888999998875 35567777776655332 22333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .+++++||++.++.....+...+...++|+|.+...... ....++++++.+++. T Consensus 62 ~~l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~---~~~~~~~~~~~~~~~ 120 (362) T 4EYQ_A 62 RRFVT------------------ESKADVIMGSSVTPPTVAVSNVANEAQVPHIALAPLPVT---PERAKWSVVMPQPIP 120 (362) T ss_dssp HHHHH------------------TSCCSEEEECSSHHHHHHHHHHHHHHTCCEEESSCCCCC---HHHHTTEEECSCCHH T ss_pred HHHHH------------------hCCCCEEEecCCChhHHHHHHHHHHhCCCEEEecCCCCC---CcccceeEEcCCCHH Confidence 43332 157889998876665556667788899999987654321 112466778888888 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ..++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++|++++ T Consensus 121 ~~~~~~~~~l~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i~~ 196 (362) T 4EYQ_A 121 IMGKVLYEHMKKNNIKTVGYIGYSDSYGDLWFNDLKKQGEAM-GLKIVAEERFA--RPDTSVAGQVLKLVA-ANPDAILV 196 (362) T ss_dssp HHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHCCCCCHHT-TCEEEEEEEEC--TTCSCCHHHHHHHHH-HCCSEEEE T ss_pred HHHHHHHHHHHhCCCcEEEEEeecChhHHHHHHHHHHHHHHc-CCeEeeeeeeC--CCCCCHHHHHHHHHH-cCCCEEEE Confidence 888899999888899999999866667777888888888765 35544322222 122345566666663 57898877 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) +..+..+..+++++++.|+. ..|++.+.+...... ........+.+........... .............|. T Consensus 197 ~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~-----~~~~~~~~~~~~~f~ 268 (362) T 4EYQ_A 197 GASGTAAALPQTALRERGYN--GLIYQTHGAASMDFI-RIAGKSAEGVLMASGPVMDPEG-----QNDSALTKKPGLELN 268 (362) T ss_dssp ECCGGGGHHHHHHHHHTTCC--SEEEECGGGCSHHHH-HHHGGGGTTCEEEECGGGCTTT-----SCTTCTTHHHHHHHH T ss_pred eCChhHhHHHHHHHHHCCCC--ceEEeccccCcHHHH-HHhhhhhcCeEEeecccCCccc-----CCChhhcCCCChHHH Confidence 66666677888888888874 356655433221110 0011122232221110000000 000000000111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+.+.++. ..+..++..+||++++++++++++....... ...+++ T Consensus 269 ~~~~~~~~~--------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~~~~~--------~~~~~~ 314 (362) T 4EYQ_A 269 TAYETKYGP--------------------------NSRSQFAGHSFDAFKVLERVIPVALKTAKPG--------TQEFRE 314 (362) T ss_dssp HHHHHHHCT--------------------------TCCCHHHHHHHHHHHHHHHHHHHHTTTCCTT--------SHHHHH T ss_pred HHHHHHHCC--------------------------CCCCccccchhHHHHHHHHHHHHHHHhCCCC--------ChHHHH Confidence 222221110 0123567789999999999998875432100 012456 Q NP_000836.2 441 ELLGYIRA-VNFNGSAGTPVTFNENGD---APGRYDIFQYQ 477 (908) Q Consensus 441 ~l~~~l~~-~~f~G~~G~~v~Fd~~G~---~~~~~~i~~~~ 477 (908) .+.++|++ ..|.|.+| ++.|+++++ +...+.+++++ T Consensus 315 ~l~~~l~~~~~~~g~~g-~~~f~~~~~~~~~~~~~~i~~~~ 354 (362) T 4EYQ_A 315 AIRKALLTEKDIAASQG-VYSFTETDRYGLDDRSRILLTVK 354 (362) T ss_dssp HHHHHHHHCCCEEETTE-EECCCSSCSSCCCGGGCEEEEEE T ss_pred HHHHHHHhcCCccccce-EEEecCCCCCCCCCCCcEEEEEE Confidence 77888877 68999988 899987654 22355666665 No 111 >3LKB_B Probable branched-chain amino acid ABC; branched amino acid, ABC transporter; HET: VAL; 2.4A {Thermus thermophilus} Probab=99.41 E-value=1.9e-17 Score=178.40 Aligned_cols=360 Identities=13% Similarity=0.146 Sum_probs=216.8 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .+.+++||+++|.++.. ...+.....+++.|++++|+.+++ +|+++++.+.|+.+++.. ..+.++ T Consensus 4 ~~~~~~Ig~~~~~~~~~----------~~~~~~~~~g~~~a~~~~n~~g~~-~g~~~~~~~~d~~~~~~~----~~~~~~ 68 (392) T 3LKB_B 4 GQQQVTLFWSGAITGPT----------SDAGAPYGAAVEDYCKWANERKLV-PGVVFNCVVRDDQYNNAN----TQRFFE 68 (392) T ss_dssp CCEEEEEEEEECSSSTT----------HHHHHHHHHHHHHHHHHHHHHTSS-TTEEEEEEEEECTTCHHH----HHHHHH T ss_pred ccCcEEEEEEecCCCCc----------cccchhhHHHHHHHHHHHHHCCCC-CCEEEEEEEEeCCCChHH----HHHHHH Confidence 45689999999986532 125567889999999999987654 477888888887665432 233333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++.+ +++++++++ ++.....+...+...++|+|......+. .....+++++++.+++.. T Consensus 69 ~l~~~------------------~~~~~ii~~-~~~~~~~~~~~~~~~~ip~i~~~~~~~~-~~~~~~~~~~~~~~~~~~ 128 (392) T 3LKB_B 69 EAVDR------------------FKIPVFLSY-ATGANLQLKPLIQELRIPTIPASMHIEL-IDPPNNDYIFLPTTSYSE 128 (392) T ss_dssp HHHHH------------------HCCSCEEEC-CHHHHHHHHHHHHHHTCCEEESCCCGGG-TSSSSCTTBCEEECCHHH T ss_pred HHHHc------------------cCCCEEEec-ccHHHHhHHHHHHHhCCCeeccccChHH-cCCCCCCceeecCCCHHH Confidence 33321 467888854 4544556667778889999987654322 111235678888999888 Q NP_000836.2 202 QAQAMVDIVT-ALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 202 ~~~~~~~~l~-~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) .++.+++++. +++|+++++++.++.++..+.+.+.+.+++. ++++.....+. ....+....+++++. .+++++++ T Consensus 129 ~~~~~~~~l~~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~ 204 (392) T 3LKB_B 129 QVVALLEYIAREKKGAKVALVVHPSPFGRAPVEDARKAAREL-GLQIVDVQEVG--SGNLDNTALLKRFEQ-AGVEYVVH 204 (392) T ss_dssp HHHHHHHHHHHHSTTCEEEEEECSSHHHHTTHHHHHHHHHHH-TCEEEEEEECC--TTCCCCHHHHHHHHH-TTCCEEEE T ss_pred HHHHHHHHHHHhcCCCeEEEEECCCHhhcccHHHHHHHHHHc-CCeEEEEEecC--CCCCCHHHHHHHHHH-cCCCEEEE Confidence 8999999984 6799999999976667777888888888775 35554322222 122345556666663 57888877 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ...+..+..+++++++.|+. ..+++.+.+...... ........+.+...... .. ........+. T Consensus 205 ~~~~~~~~~~~~~~~~~g~~--~~i~~~~~~~~~~~~-~~~~~~~~g~~~~~~~~----------~~---~~~~~~~~~~ 268 (392) T 3LKB_B 205 QNVAGPVANILKDAKRLGLK--MRHLGAHYTGGPDLI-ALAGDAAEGFLWATSFY----------MA---HEDTPGIRLQ 268 (392) T ss_dssp ESCHHHHHHHHHHHHHTTCC--CEEEECGGGCSHHHH-HHHGGGGTTCEEEESBC----------CT---TSCCHHHHHH T ss_pred eCCChhHHHHHHHHHHcCCC--CcEEEccccCCHHHH-HHHHHHhCCEEEEeccC----------CC---CCCCHHHHHH Confidence 76566677889999888874 345554432221110 00111122222111100 00 0000111122 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+.+.++... ..........+||++++++.|++++.... ...+++ T Consensus 269 ~~~~~~~~~~~-----------------------~~~~~~~~~~~yda~~~l~~al~~~~~~~-----------~~~~~~ 314 (392) T 3LKB_B 269 KEIGRKYGRPE-----------------------NFIESVNYTNGMLAAAIAVEAIRRAQERF-----------KRITNE 314 (392) T ss_dssp HHHHHHTTCCH-----------------------HHHTCHHHHHHHHHHHHHHHHHHHHHHHH-----------SCCSHH T ss_pred HHHHHHHCCCc-----------------------hhhcchHHHHHHHHHHHHHHHHHHHHHHh-----------CCCCHH Confidence 22222221100 00000112268999999999998875421 012455 Q NP_000836.2 441 ELLGYIRAVN----------FNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 441 ~l~~~l~~~~----------f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .+.+.|++.. |.|.+|.++.|+++|++. ..+.+++++ ++.++.|+.|... T Consensus 315 ~l~~~l~~~~~~~~~~~~~~~~g~~G~~i~f~~~~~~~~~~~~i~~~~----~g~~~~v~~~~~~ 375 (392) T 3LKB_B 315 TVYQAIVGMNGPNAFKPGFAVSTKQGVEIDFTKSEHTGAEGLRILEAK----GGRFVPVTEPFTS 375 (392) T ss_dssp HHHHHHHTCSGGGCBCCSSBCCCSSSCSBCCCSSCCEEECCBEEEEEE----TTEEEECSCCBCC T ss_pred HHHHHHHhccCCCCCCCccccccCCcceeeeccCCCCCCccEEEEEEc----CCEEEECCCCcCH Confidence 6667776553 556665369999887765 567787776 3578999999865 No 112 >4F8J_A Putative branched-chain amino acid transport; lignin degratation, Structural Genomics, PSI-Biology; HET: GOL, EPE, SO4, HC4; 1.6A {Rhodopseudomonas palustris} Probab=99.39 E-value=2.8e-17 Score=174.67 Aligned_cols=348 Identities=14% Similarity=0.158 Sum_probs=206.1 Template_Neff=12.300 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||+++|..+... ..+.....+++.+++++| |+++++.+.|+.+++. ...+.+ T Consensus 3 ~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~-------g~~~~~~~~d~~~~~~----~~~~~~ 61 (362) T 4F8J_A 3 AETNEITIGITVTTTGPAA----------ALGIPERNALEFVAKEIG-------GHPLKVIVLDDGGDPT----AATTNA 61 (362) T ss_dssp -CCSSEEEEEEECCSSTTH----------HHHHHHHHGGGGSCSEET-------TEEEEEEEEECTTCHH----HHHHHH T ss_pred ccCCceEEEEEEcCCCchH----------HhCchHHHHHHHHHHHhC-------CEEEEEEEEeCCCCHH----HHHHHH Confidence 3456899999999875321 245677888888888875 4567777777655532 222333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .++++++|++.++.....+...+...++|+|..+..... ....++++++.+++. T Consensus 62 ~~~~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~---~~~~~~~~~~~~~~~ 120 (362) T 4F8J_A 62 RRFVT------------------ESKADVIMGSSVTPPTVAVSNVANEAQVPHIALAPLPIT---PERAKWSVAMPQPIP 120 (362) T ss_dssp HCCCC------------------CSCCSEEEECSSHHHHHHHHHHHHHHTCCEEESSCCCCC---TTTTTTEEECSCCHH T ss_pred HHHHh------------------hcCCCEEEecCCChHHHHHHHHHHHhCCCEEEcCCCCCC---ccccceeeecCCChH Confidence 33332 157899998876665556677788899999987653221 113467788888888 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ..++.+++++.+.+|++|++++.++.++..+.+.+++.+++. ++++.....+. ....+....+++++. .+++++++ T Consensus 121 ~~~~~~~~~l~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~ 196 (362) T 4F8J_A 121 IMGKVLYEHMKKNNIKTVGYIGYSDSYGDLWFNDLKKQGEAM-GLKIVAEERFA--RPDTSVAGQVLKLVA-ANPDAILV 196 (362) T ss_dssp HHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHCCCCCHHT-TCEEEEEEEEC--TTCSCCHHHHHHHHH-HCCSEEEE T ss_pred HHHHHHHHHHHhCCCeEEEEEEecCcchHHHHHHHHHHHHHc-CCEEEeeeeeC--CCCCChHHHHHHHHH-cCCCEEEE Confidence 888899999888899999999966667777788888887765 35554322222 122345556666653 57888877 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) +.++..+..+++++++.|+. ..|++.+.+...... ........+.+........... . ... .........|. T Consensus 197 ~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~---~-~~~-~~~~~~~~~f~ 268 (362) T 4F8J_A 197 GASGTAAALPQTSLRERGYK--GLIYQTHGAASMDFI-RIAGKSAEGVLMASGPVMDPEG---Q-DDS-ALTKKPGLELN 268 (362) T ss_dssp ECCHHHHHHHHHHHHHTTCC--SEEEECGGGCBTHHH-HHHGGGGTTCEEEECGGGCGGG---S-CTT-CTTHHHHHHHH T ss_pred eCCHHHchHHHHHHHHCCCC--ceEEeecccCCHHHH-HHccccccCeEEecccccCcCC---C-Cch-hhcCCcchHHH Confidence 76666677888998888874 355555433221110 0011122232221110000000 0 000 00000111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++. ..++.++..+||+++++++|++++....... ...+++ T Consensus 269 ~~~~~~~~~--------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~~~~~--------~~~~~~ 314 (362) T 4F8J_A 269 TAYEAKYGP--------------------------NSRSQFAAHSFDAFKVLERVVPVALKTAKPG--------TQEFRE 314 (362) T ss_dssp HHHHHHHCT--------------------------TCCBHHHHHHHHHHHHHHHHHHHHHTTCCTT--------SHHHHH T ss_pred HHHHHHHCC--------------------------CCCCccccchhHHHHHHHHHHHHHHHhCCCC--------CHHHHH Confidence 222221110 0123567889999999999998665432100 013456 Q NP_000836.2 441 ELLGYIRA-VNFNGSAGTPVTFNENGDA---PGRYDIFQYQ 477 (908) Q Consensus 441 ~l~~~l~~-~~f~G~~G~~v~Fd~~G~~---~~~~~i~~~~ 477 (908) .+.+.|++ ..|.|.+| ++.|+++++. ...+.+++++ T Consensus 315 ~l~~~l~~~~~~~g~~g-~i~f~~~~~~~~~~~~~~i~~~~ 354 (362) T 4F8J_A 315 AIRKALVSEKDIAASQG-VYSFTETDRYGLDDRSRILLTVK 354 (362) T ss_dssp HHHHHHHHSCCEECSSC-EECCCSSCSSCCCGGGCEEEEEE T ss_pred HHHHHHHhccCccccce-eEEecCCCCCCcCcCCcEEEEEE Confidence 78888887 58999988 8999986542 2356677765 No 113 >4U4G_D GluA2*; Ionotropic glutamate receptor, AMPA receptor; HET: NAG, ZK1, BMA; 4.49A {Rattus norvegicus} Probab=99.39 E-value=2.9e-17 Score=195.81 Aligned_cols=356 Identities=15% Similarity=0.188 Sum_probs=224.1 Template_Neff=11.500 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~~~~ 122 (908) ++++||++.|.++. ....|++.|++++|++ |+++++.+.|+. +++. .+.+.+++ T Consensus 1 ~~i~Ig~~~~~~g~----------------~~~~g~~~a~~~in~~-----g~~l~~~~~d~~~~~~~----~~~~~~~~ 55 (822) T 4U4G_D 1 NSIQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSF----AVTNAFCS 55 (822) T ss_dssp CEEEEEEEEETTCH----------------HHHHHHHHHHHHHCCS-----SCEEEEEEEEECTTCHH----HHHHHHHH T ss_pred CceeEEEecCCCCh----------------HHHHHHHHHHhhccCC-----CceeeeeEEecCCCCHH----HHHHHHHH Confidence 36899999988742 4678999999999975 467888888865 3322 22233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) +.. +++++++|+.++..+.++++.+...++|+++++.+++ ..+++++++.++ . T Consensus 56 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~---~ 108 (822) T 4U4G_D 56 QFS-------------------RGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPD---L 108 (822) T ss_dssp HHH-------------------HCCSCEEECCCTTTHHHHHHHHHHHCCCEEESSCCCS-----SCCSSEEECSCC---C T ss_pred HHh-------------------hCeeEEEecCChhHHHHHHHHHhccCCeEEeCCCCCC-----CCCCeEEEecCC---H Confidence 332 5789999998887777888888899999998876543 246889999887 4 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPR--EPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ++.+++++++++|+++++++ +++++....+.+++.+++. ++++.....++. +.+..++...++++++ .++|+|++ T Consensus 109 ~~~~~~~l~~~~~~~v~iv~-~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~i~~ 185 (822) T 4U4G_D 109 KGALLSLIEYYQWDKFAYLY-DSDRGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKERRVIL 185 (822) T ss_dssp HHHHHHHHHHTTCCEEEEEE-CGGGCTHHHHHHHHHHHHH-TCEEEEEECSSCCSSSCSTTTTTHHHHTTS-SCCCEEEE T ss_pred HHHHHHHHHHcCCCEEEEEE-cCcchHHHHHHHHHHHHhc-CCeEEEEEccCCCCCCCcchhHHHHHHHHh-cCCcEEEE Confidence 67788888888999999999 5667777777787777764 455544332210 0122456667777763 57899988 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) .+....+..+++++++.|+.. .+.|++.+.+...... ........+....... ....+....| T Consensus 186 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~---------------~~~~~~~~~f 249 (822) T 4U4G_D 186 DCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGAEVSGFQIV---------------DYDDSLVSKF 249 (822) T ss_dssp ESCHHHHHHHHHHHHHHTCSSTTCEEEECSSBTTTSCC-TTTTTSSCEEEEEESS---------------CTTSHHHHHH T ss_pred ECCHHHHHHHHHHHHHhCCCCCCeEEEEeeCCCCCCch-HhcccCCeeEEEEEEe---------------eCCchHHHHH Confidence 877767788899998888753 3566665422211100 0000001111111000 0011122233 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~~~~- 434 (908) .+.+++.++.... + . ....++.++..+|||++++++|++++...... .....|... T Consensus 250 ~~~~~~~~~~~~~-----------~--~------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~~~~~~ 310 (822) T 4U4G_D 250 IERWSTLEEKEYP-----------G--A------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANP 310 (822) T ss_dssp HHHHTTSCTTTST-----------T--C------CSSCCCHHHHHHHHHHHHHHHHHHHHHHTTCCCCCSSCCCCTTCSS T ss_pred HHHHHhcchhcCC-----------C--C------CCCCCchhHHHHHHHHHHHHHHHHHHHHhccccccCCCCCCCccCC Confidence 3434333321000 0 0 00123456788999999999999998653210 001122211 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ...+++.+.++|++..|.|.+| ++.|+++|++.. .+.+++++ ++.++.+|.|... T Consensus 311 ~~~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~v~~~~~~ 368 (822) T 4U4G_D 311 AVPWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEV 368 (822) T ss_dssp CCCCTTHHHHHHHHHHCCEEETTE-EECBCTTCCBCSCCEEEEEEE----TTEEEEEEEEETT T ss_pred CCCccchHHHHHHHHhccccCCCc-cEEECCCCcEEEeEEEEEEec----CCCceeeEEeeCC Confidence 1124567888888889999988 899999888764 78888887 3568888888753 No 114 >6PEQ_D Glutamate receptor 2, Protein cornichon; ionotropic glutamate receptor, AMPA receptor; HET: CLR, OLC, PAM, ZK1; 2.97A {Rattus norvegicus} Probab=99.39 E-value=3.4e-17 Score=196.89 Aligned_cols=360 Identities=15% Similarity=0.192 Sum_probs=225.1 Template_Neff=11.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILD-TCSRDTYALEQSLT 118 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d-~~~~~~~a~~~~~~ 118 (908) ...+++++||++.|.++. ....|++.|++++|++ |.++++.+.| +++++.. +.+ T Consensus 21 ~~~~~~i~Ig~~~~~~g~----------------~~~~g~~~a~~~in~~-----g~~l~~~~~d~~~~~~~~----~~~ 75 (889) T 6PEQ_D 21 GVSSNSIQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFA----VTN 75 (889) T ss_pred hccCCeEEEeEeeCCCCh----------------HHHHHHHHHHHhcccc-----CceeccceeecCccCHHH----HHH Confidence 456689999999998652 4678999999999975 4678888888 4444322 223 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++++. +++++++|+.++..+.+++..+...++|++++...++ ..+++++++.++ T Consensus 76 ~~~~l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~ 131 (889) T 6PEQ_D 76 AFCSQFS-------------------RGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPD 131 (889) T ss_pred HHHHHHh-------------------cCeeEEEEcCChHHHHHHHHHHhccCCcEEEcCCCCC-----CCCCcEEEeecC Confidence 3333332 5789999998887777888888999999998876443 247889999887 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPR--EPRPGEFEKIIKRLLETPNAR 276 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~ 276 (908) .++++++++++++|+++++++ +++++....+.+++.+++. ++++......+. ..+..++...++++++ .++| T Consensus 132 ---~~~~~~~~~~~~~~~~v~ii~-~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~i~~-~~~~ 205 (889) T 6PEQ_D 132 ---LKGALLSLIEYYQWDKFAYLY-DSDRGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKER 205 (889) T ss_pred ---hHHHHHHHHHHhCCCEEEEEE-eCcchhHHHHHHHHHHHhh-CCeEEEEEccCCCCCCCchhhHHHHHHhcc-CCCe Confidence 577888888888999999999 5567777777787777765 355543322210 0112355667777763 5789 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRR 355 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 355 (908) +|++...+..+..+++++++.|+.. .+.|++.+.+...... ........+....... ....+. T Consensus 206 ~vi~~~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~---------------~~~~~~ 269 (889) T 6PEQ_D 206 RVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGANVSGFQIV---------------DYDDSL 269 (889) T ss_pred EEEEECCHHHHHHHHHHHHHhCCCCCCeEEEEEeCCCCcccH-HHhccCCcceEEEEEe---------------eCCcHH Confidence 9988877777888999998888753 4567765532221100 0000001111110000 000111 Q NP_000836.2 356 NVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLC 431 (908) Q Consensus 356 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~ 431 (908) ...|.+.+.+.++.. +... ....++.++..+|||+++++.|++++...... .....| T Consensus 270 ~~~f~~~~~~~~~~~-------------~~~~------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~~ 330 (889) T 6PEQ_D 270 VSKFIERWSTLEEKE-------------YPGA------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDC 330 (889) T ss_pred HHHHHHHHHhccccc-------------CCCC------CCCCCChHHHHHHHHHHHHHHHHHHHHHhhhccccCCCCCCC Confidence 222333333332210 0000 00123456788999999999999988643210 000122 Q NP_000836.2 432 PRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 432 ~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ... ...++..+.+.|++..|.|.+| ++.||++|++.. .+.+.+++ ++.++.++.|... T Consensus 331 ~~~~~~~~~~~~~i~~~l~~~~~~g~~G-~v~f~~~g~~~~~~~~i~~~~----~~~~~~~~~~~~~ 392 (889) T 6PEQ_D 331 LANPAVPWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEV 392 (889) T ss_pred CCCCCCCccchHHHHHHHHhcCccCCCc-cEEECCCCcEeeeEEEEEEec----cCCceEEEEEeCC Confidence 110 1124566778888889999988 899999888754 78888887 2457777878754 No 115 >3UK0_A Extracellular ligand-binding receptor; STRUCTURAL GENOMICS, PSI-BIOLOGY, MIDWEST CENTER; HET: ENO, MSE, SO4; 1.49A {Rhodopseudomonas palustris} Probab=99.38 E-value=3.5e-17 Score=173.93 Aligned_cols=348 Identities=14% Similarity=0.163 Sum_probs=203.7 Template_Neff=12.200 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||+++|.++... ..+.....+++.+++++| |.++++.+.|+.+++.. ..+.+ T Consensus 3 ~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~~~~~a~~~~~-------g~~~~~~~~~~~~~~~~----~~~~~ 61 (362) T 3UK0_A 3 AETNEITVGISVTTTGPAA----------ALGIPERNALEFVVKEIS-------GHPIKIIVLDDGGDPTA----ATTNA 61 (362) T ss_dssp -CCCCEEEEEEECCSSTTH----------HHHHHHHHGGGGSCSEET-------TEEEEEEEEECTTCHHH----HHHHH T ss_pred ccCCcEEEEEEEecCCCcH----------HhCCCHHHHHHHHHHHhc-------CeEEEEEEEeCCCCHHH----HHHHH Confidence 3456899999999865321 245677889999999987 34566667776555332 22333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .+++++||++.++.....+...+...++|+|........ ....++++++.+++. T Consensus 62 ~~l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~---~~~~~~~~~~~~~~~ 120 (362) T 3UK0_A 62 RRFVT------------------ESKADVIMGSSVTPPSVAISNVANEAQIPHIALAPLPIT---PERAKWSVVMPQPIP 120 (362) T ss_dssp HHHHH------------------TSCCSEEEECSSHHHHHHHHHHHHHHTCCEEESSCCCCC---TTTTTTEEECSCCHH T ss_pred HHHHH------------------hcCCCEEEecCCChHHHHHHHHHHHcCCCEEEccCCCCC---CcccCceeecCCCHH Confidence 33332 157889998776655556667778889999987654221 112466788888888 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ..++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. ....+....+++++. .+++++++ T Consensus 121 ~~~~~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~ 196 (362) T 3UK0_A 121 IMGKVLYEHMKKNNVKTVGYIGYSDSYGDLWFNDLKKQGEAM-GLKIVGEERFA--RPDTSVAGQALKLVA-ANPDAILV 196 (362) T ss_dssp HHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHCCCCCHHT-TCEEEEEEEEC--TTCSCCHHHHHHHHH-HCCSEEEE T ss_pred HHHHHHHHHHHHCCCCEEEEEEecCcchHHHHHHHHHHHHHc-CCEEeeEEEeC--CCCCChHHHHHHHHH-cCCCEEEE Confidence 888889998887899999999966667777888888888765 35544322222 112334455666653 47888867 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) +..+..+..+++++++.|+. ..+++.+.+...... ........+.+........... .............|. T Consensus 197 ~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~g~~~~~~~~~~~~~-----~~~~~~~~~~~~~f~ 268 (362) T 3UK0_A 197 GASGTAAALPQTTLRERGYN--GLIYQTHGAASMDFI-RIAGKSAEGVLMASGPVMDPEG-----QDDTALTKKPGMALV 268 (362) T ss_dssp ECCHHHHHHHHHHHHHTTCC--SEEEECGGGCSHHHH-HHHGGGGTTCEEEECGGGCSTT-----SCTTCTTHHHHHHHH T ss_pred eCCHHHchhHHHHHHHcCCc--ceEEEcCcccCHHHH-HHhhhhhcCcEEeecCCCCCCC-----CCchhccCcchHHHH Confidence 66666677888998888874 355555433221110 0011122333221110000000 000000000111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.|++.++. ..++.++..+||+++++++++++++...... ....++ T Consensus 269 ~~~~~~~~~--------------------------~~~~~~~~~~yda~~~~~~a~~~a~~~~~~~--------~~~~~~ 314 (362) T 3UK0_A 269 KVYEEKYGP--------------------------SSRSQFAGHSYDAFKVLERVVPVALKKAKPG--------TQEFRE 314 (362) T ss_dssp HHHHHHHCT--------------------------TCCCHHHHHHHHHHHHHHHHHHHHHTTCCTT--------SHHHHH T ss_pred HHHHHHHCC--------------------------CCCCcccccchhHHHHHHHHHHHHHHhcCCC--------CHHHHH Confidence 222221110 0123567789999999999877665432100 112455 Q NP_000836.2 441 ELLGYIRA-VNFNGSAGTPVTFNENGD---APGRYDIFQYQ 477 (908) Q Consensus 441 ~l~~~l~~-~~f~G~~G~~v~Fd~~G~---~~~~~~i~~~~ 477 (908) .+.++|++ ..|+|.+| ++.|+++++ +...+.+++++ T Consensus 315 ~l~~~l~~~~~~~g~~g-~i~f~~~~~~~~~~~~~~i~~~~ 354 (362) T 3UK0_A 315 ALREAFLTEKDIAASQG-VYNFTETDRYGLDDRSRILLTVK 354 (362) T ss_dssp HHHHHHHHCCCEECSSC-EECCCSSCSSCCCGGGCEEEEEE T ss_pred HHHHHHHcCCccccccc-eEEeCCCCccccCccceEEEEEE Confidence 67777775 57899888 899987643 22355666665 No 116 >4TLL_C GluN1/GluN2B; Neurotransmitter receptor, NMDA receptor, GluN1/GluN2B; HET: JEG, QEM, NAG; 3.59A {Xenopus laevis} Probab=99.38 E-value=3.6e-17 Score=194.78 Aligned_cols=349 Identities=18% Similarity=0.271 Sum_probs=228.5 Template_Neff=11.000 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.++ ...|++.|++++|+.+ .|.++++...|+.+++.. .+...+.+++ T Consensus 3 ~~~i~IG~i~~~~~------------------~~~~~~~a~~~~n~~g---~g~~i~l~~~d~~~~~~~-~~~~~~~~~~ 60 (823) T 4TLL_C 3 PKIVNIGAVLSTKK------------------HEQIFREAVNQANFFH---FTRKIQLNATSVTHRPNA-IQMALSVCED 60 (823) T ss_dssp CEEEEEEEEESSHH------------------HHHHHHHHHHHHHHSS---CTTTEEEEECCEECCSSH-HHHHHHCCCC T ss_pred CceeeeeEEecCch------------------HHHHHHHHHHHHhhcc---CCCceeccccccCCCCCH-HHHHHHHHHH Confidence 47899999998752 4578999999999865 267788888887655332 0113333333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-----IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-----~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +.. +++++++|+.++..+ ..++..+...++|+|++.+..+.+.++..+++++++.+ T Consensus 61 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~ 121 (823) T 4TLL_C 61 LIS-------------------SQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVP 121 (823) T ss_dssp CGG-------------------GCCSCEEECCCSSCCTTCTTHHHHHHHHHTTCCEEESSCCCGGGSCTTTCSSEEESSC T ss_pred HHh-------------------cCceEEEEcCCCCCCCcCCchHHHHhhccccCCEEEeecCCcccCCCCcccceeecCC Confidence 332 478999998887776 55666888899999998876665554335788999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ++..+++++++++++++|+++++++.+++++....+.+++.+++. ++++.....+. .+..+....++++++ .++|+ T Consensus 122 ~~~~~~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ 197 (823) T 4TLL_C 122 PYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEK-ESKADKVLQFE--PGTKNLTALLLEAKE-LEARV 197 (823) T ss_dssp CSGGGHHHHHHHHHHHTCCCCEEEEESSHHHHHHHHHHHHHHTSS-TTCCCEEEEEC--TTCSCCHHHHHHHHH-SSCCE T ss_pred CHHHHHHHHHHHHHHcCCCEEEEEEecCcchHHHHHHHHHHHHhc-cccccEEeccC--CCCccHHHHHHHHHh-CCceE Confidence 999999999999988899999999987788888888888888775 45554333232 122345666777763 57899 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) |++.+.+..+..+++++++.|+.. .+.|++.+.+.... .......+.+. T Consensus 198 vv~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~----~~~~~~~~~~~-------------------------- 247 (823) T 4TLL_C 198 IILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGS----ALRYAPDGIIG-------------------------- 247 (823) T ss_dssp EEEECCHHHHHHHHHHHHHTTTTSTTCEEEECTTTSSTH----HHHSCCTTCEE-------------------------- T ss_pred EEEECCHHHHHHHHHHHHhcCccCCCeEEEEecCCCCch----hhhcCCCceEE-------------------------- Confidence 888877777888999998888753 34455543221110 00000000000 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGY-IGLCPRM- 434 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~-~~~~~~~- 434 (908) ... ..+..++..+|||++.++.|+++......... ...|... T Consensus 248 ---~~~---------------------------------~~~~~~~~~~ydav~~~~~a~~~~~~~~~~~~~~~~~~~~~ 291 (823) T 4TLL_C 248 ---LQL---------------------------------INGKNESAHISDAVAVVAQAIHELFEMEQITDPPRGCVGNT 291 (823) T ss_dssp ---EEE---------------------------------TTSSCSHHHHHHHHHHHHHHHHHHTTSSSCCCCCSCSTTCC T ss_pred ---EEE---------------------------------cCCCCccchHHHHHHHHHHHHHHHHhcCCCCCCCCCcCCCC Confidence 000 00122456789999999999988764321110 0111110 Q NP_000836.2 435 -STIDGKELLGYIRAV-NFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLH-LKVEDMQWAHR 507 (908) Q Consensus 435 -~~~~~~~l~~~l~~~-~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~-~~~~~i~w~~~ 507 (908) ...+++.+.+.|++. .|.|.+| .+.||++|++. ..+.+.+++ ++.++.++.|+.... .....+.|+.+ T Consensus 292 ~~~~~~~~l~~~l~~~~~~~G~~G-~i~fd~~g~~~~~~~~i~~~~----~~~~~~~~~~~~~~~~~~~~~~~~~~~ 363 (823) T 4TLL_C 292 NIWKTGPLFKRVLMSSKYPDGVTG-RIEFNEDGDRKFAQYSIMNLQ----NRKLVQVGIFDGSYIIQNDRKIIWPGG 363 (823) T ss_dssp SCCTTHHHHHHHHHTCCCTTCTTS-CCEECTTSCEESCCEEEEEEC----SSSEEEEEEECSSSCEECSSCCCCTTS T ss_pred CccccHHHHHHHHHcCCCCCCccc-cEEECCCCCEEeeEEEEEEcc----CCceEEEEEeeCCceeecCCceeCCCC Confidence 012345677777754 6889888 89999988874 677788876 357899999986532 12224667653 No 117 >4TLM_C GluN1/GluN2B; neurotransmitter receptor, NMDA receptor, GluN1/GluN2B; HET: NAG, QEM, JEG; 3.77A {Xenopus laevis} Probab=99.38 E-value=3.6e-17 Score=194.78 Aligned_cols=349 Identities=18% Similarity=0.271 Sum_probs=228.5 Template_Neff=11.000 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.++ ...|++.|++++|+.+ .|.++++...|+.+++.. .+...+.+++ T Consensus 3 ~~~i~IG~i~~~~~------------------~~~~~~~a~~~~n~~g---~g~~i~l~~~d~~~~~~~-~~~~~~~~~~ 60 (823) T 4TLM_C 3 PKIVNIGAVLSTKK------------------HEQIFREAVNQANFFH---FTRKIQLNATSVTHRPNA-IQMALSVCED 60 (823) T ss_dssp CCEEEEEEEESCHH------------------HHHHHHHHHHHHHHTS---CTTTCEEEEEEEECCSSH-HHHHHHCCCC T ss_pred CceeeeeEEecCch------------------HHHHHHHHHHHHhhcc---CCCceeccccccCCCCCH-HHHHHHHHHH Confidence 47899999998752 4578999999999865 267788888887655332 0113333333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-----IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-----~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +.. +++++++|+.++..+ ..++..+...++|+|++.+..+.+.++..+++++++.+ T Consensus 61 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~ 121 (823) T 4TLM_C 61 LIS-------------------SQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVP 121 (823) T ss_dssp CGG-------------------GTCSCEEECCCSSCCSSCTTSHHHHHHHHHTCCEEESSCCCGGGSCTTTCSSEEESSC T ss_pred HHh-------------------cCceEEEEcCCCCCCCcCCchHHHHhhccccCCEEEeecCCcccCCCCcccceeecCC Confidence 332 478999998887776 55666888899999998876665554335788999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ++..+++++++++++++|+++++++.+++++....+.+++.+++. ++++.....+. .+..+....++++++ .++|+ T Consensus 122 ~~~~~~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ 197 (823) T 4TLM_C 122 PYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEK-ESKADKVLQFE--PGTKNLTALLLEAKE-LEARV 197 (823) T ss_dssp CTTTHHHHHHHHHHHHTCCCCEEEEESSHHHHHHHHHHHHHHHHS-SCCCSCEEEEC--TTCSCCHHHHHHHHH-SSCCE T ss_pred CHHHHHHHHHHHHHHcCCCEEEEEEecCcchHHHHHHHHHHHHhc-cccccEEeccC--CCCccHHHHHHHHHh-CCceE Confidence 999999999999988899999999987788888888888888775 45554333232 122345666777763 57899 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) |++.+.+..+..+++++++.|+.. .+.|++.+.+.... .......+.+. T Consensus 198 vv~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~----~~~~~~~~~~~-------------------------- 247 (823) T 4TLM_C 198 IILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGS----ALRYAPDGIIG-------------------------- 247 (823) T ss_dssp EEEECCHHHHHHHHHHHHHTTTTSTTCEEEECHHHHSTH----HHHHCCTTCEE-------------------------- T ss_pred EEEECCHHHHHHHHHHHHhcCccCCCeEEEEecCCCCch----hhhcCCCceEE-------------------------- Confidence 888877777888999998888753 34455543221110 00000000000 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGY-IGLCPRM- 434 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~-~~~~~~~- 434 (908) ... ..+..++..+|||++.++.|+++......... ...|... T Consensus 248 ---~~~---------------------------------~~~~~~~~~~ydav~~~~~a~~~~~~~~~~~~~~~~~~~~~ 291 (823) T 4TLM_C 248 ---LQL---------------------------------INGKNESAHISDAVAVVAQAIHELFEMEQITDPPRGCVGNT 291 (823) T ss_dssp ---EEE---------------------------------TTSSCHHHHHHHHHHHHHHHHHHHTTSSCCCCCCSSSTTCC T ss_pred ---EEE---------------------------------cCCCCccchHHHHHHHHHHHHHHHHhcCCCCCCCCCcCCCC Confidence 000 00122456789999999999988764321110 0111110 Q NP_000836.2 435 -STIDGKELLGYIRAV-NFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLH-LKVEDMQWAHR 507 (908) Q Consensus 435 -~~~~~~~l~~~l~~~-~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~-~~~~~i~w~~~ 507 (908) ...+++.+.+.|++. .|.|.+| .+.||++|++. ..+.+.+++ ++.++.++.|+.... .....+.|+.+ T Consensus 292 ~~~~~~~~l~~~l~~~~~~~G~~G-~i~fd~~g~~~~~~~~i~~~~----~~~~~~~~~~~~~~~~~~~~~~~~~~~ 363 (823) T 4TLM_C 292 NIWKTGPLFKRVLMSSKYPDGVTG-RIEFNEDGDRKFAQYSIMNLQ----NRKLVQVGIFDGSYIIQNDRKIIWPGG 363 (823) T ss_dssp SCCTHHHHHHHHHHTCCCCCCSSC-CCCBCTTSCBCSCCEEEEECG----GGSCEEEEEEETTEEEECSSCCCCSSS T ss_pred CccccHHHHHHHHHcCCCCCCccc-cEEECCCCCEEeeEEEEEEcc----CCceEEEEEeeCCceeecCCceeCCCC Confidence 012345677777754 6889888 89999988874 677788876 357899999986532 12224667653 No 118 >4MPT_B Putative leu/ile/val-binding protein; Structural Genomics, PSI-Biology, Midwest Center; HET: ACY, MSE; 1.75A {Bordetella pertussis Tohama I} Probab=99.38 E-value=3.6e-17 Score=175.27 Aligned_cols=354 Identities=16% Similarity=0.200 Sum_probs=209.4 Template_Neff=11.900 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVR-ILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~-~~d~~~~~~~a~~~~~~~~ 120 (908) .+++++||+++|.++... ..+.....|++.|++++|+.+++. |+++++. +.|+.+++.. ..+.+ T Consensus 3 ~~~~~~Ig~~~~~~~~~~----------~~~~~~~~~~~~a~~~~n~~~g~~-g~~v~l~~~~d~~~~~~~----~~~~~ 67 (380) T 4MPT_B 3 AADTIKIGMTSALTGPYN----------EFGEGNRRAVELAVEQWNAKGGIN-GKKIEIAMLLDDQLNPDR----AVQNI 67 (380) T ss_dssp --CEEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHTTTSBT-TBEEEEEEEEECTTCHHH----HHHHH T ss_pred cCCceEEEEEecCCCCch----------HHhHHHHHHHHHHHHHHHHCCCCC-CeEEEEEEEEcCCCCHHH----HHHHH Confidence 457899999999875421 245678899999999999876543 6778877 6776655432 33344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSD------NTRYDFFSR 194 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~------~~~~~~~~~ 194 (908) ++++.+ ++++++||+.++.....+...+...++|+|......+.+.. ...++++++ T Consensus 68 ~~l~~~------------------~~~~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~ 129 (380) T 4MPT_B 68 RAILDN------------------KDIVGIIGPAGSGPMLAVIDMVQADGRPYMNPIAQTPVVTYPGEKTGEKPRPNVFS 129 (380) T ss_dssp HHHHTC------------------TTCCCEECCSSHHHHHHHHHHHHHHCSCEEECSCCCGGGTCTTSSTTSSCCTTEEE T ss_pred HHHHhc------------------CCEEEEECCCCCHHHHHHHHHHHHhCCcEEcccCCCCcccCCCCcCCCCCCCceEE Confidence 444321 47889999887766667778888899999988766554321 113577899 Q NP_000836.2 195 VVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 195 ~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) +.+++...+..+++++.+ +|++|++++.++.++..+.+.+++.+++..++++.....+. .+..++...+++++. .+ T Consensus 130 ~~~~~~~~~~~~~~~l~~-~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~~~v~~~~~~~--~~~~~~~~~~~~~~~-~~ 205 (380) T 4MPT_B 130 FALQNDIEAVAMGEYLAK-KFKRVGIIHESTAYGVTGVDYLAASIAKNGGAKPVATDSYN--QGAQDMTAQVARMKR-AN 205 (380) T ss_dssp CSCCHHHHHHHHHHHHHH-HCSSEEEEEESSHHHHHHHHHHHHHHHHTTCCCCSEEEEEC--TTCSCCHHHHHHHHT-TT T ss_pred EecCchHHHHHHHHHHHh-hCCeEEEEecCChhhhhHHHHHHHHHHHcCCCeeeEEEeec--CCCCchHHHHHHHHH-CC Confidence 999988888888888876 89999999966667777888888777653224443322222 122345566666663 57 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNR 354 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~ 354 (908) ++++++...+..+..+++++++.|+. ..+++.+.+...... ........+.+...... +.. ...+ T Consensus 206 ~~~i~~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~---------~~~---~~~~ 270 (380) T 4MPT_B 206 VDAIAAIGLGKDLAVLRRTMARLNVN--VPLAASNGALGQPYQ-EGAGELTLGTLGTMIGA---------FGN---PMRA 270 (380) T ss_dssp CSEEEEESCHHHHHHHHHHHHHTTCC--CCEEECGGGGSHHHH-HHHGGGGTTCEEEEECT---------TSS---SCCH T ss_pred CCEEEEEcCchHHHHHHHHHHHcCCC--CCEEEcchhcCHHHH-HHhhHhhCCeeEEeecc---------cCC---CCCh Confidence 88887776666677888888887764 345554432211100 00011112221111000 000 0001 Q NP_000836.2 355 RNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM 434 (908) Q Consensus 355 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~ 434 (908) ....|.+.+.+.++...... . .. .........++..+|||+++++++++++.. T Consensus 271 ~~~~f~~~~~~~~~~~~~~~---~----~~-------~~~~~~~~~~~~~~yda~~~~~~a~~~~~~------------- 323 (380) T 4MPT_B 271 PAADFAKAYKAKYGTDRWWG---N----DP-------ENPQLFMAISVSNGYDAANILFEGIRLANS------------- 323 (380) T ss_dssp HHHHHHHHHHHHHCSCTTTC---S----CT-------TSCCTTHCCCCCHHHHHHHHHHHHHHHHTS------------- T ss_pred HHHHHHHHHHHHHCCCccCC---C----CC-------CCchhhhhHHHHHHHHHHHHHHHHHHHcCC------------- Confidence 11223333332221100000 0 00 000000012367899999999999987642 Q NP_000836.2 435 STIDGKELLGYIRAV-NFNGSAGTPVTFNENGDA---PGRYDIFQYQ 477 (908) Q Consensus 435 ~~~~~~~l~~~l~~~-~f~G~~G~~v~Fd~~G~~---~~~~~i~~~~ 477 (908) .++..+.++|++. .|.|.+| ++.|+++|++ ...+.++++. T Consensus 324 --~~~~~i~~~l~~~~~~~g~~g-~~~f~~~~~~~~~~~~~~v~~~~ 367 (380) T 4MPT_B 324 --TDPKAVIAAIESIKDYQGVNT-AYTFSKERHHGIETDGVKVFEYV 367 (380) T ss_dssp --CCHHHHHHHHTTCCSEECSSC-EECCCSSCCBCCCGGGEEEEEEE T ss_pred --CCHHHHHHHHHcCCCcccccc-eEEeecCcccccccceeEEEEEE Confidence 1345677788765 7899888 8999986543 2356666665 No 119 >4ZPJ_A Extracellular ligand-binding receptor; ABC transporter, substrate-binding protein, DUF3597; HET: ZN, MSE; 2.24A {Sphaerobacter thermophilus (strain DSM 20745 / S 6022)} Probab=99.37 E-value=5.1e-17 Score=177.05 Aligned_cols=346 Identities=19% Similarity=0.206 Sum_probs=206.4 Template_Neff=11.500 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||++.|.++... ..+.....+++.|++++|+. ..|+++++.+.|+.+++.. ..+ T Consensus 48 ~~~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~---~~g~~~~l~~~d~~~~~~~----~~~ 110 (423) T 4ZPJ_A 48 SSASGEPIRIGVLLTLSGPQG----------VNGEGNLRGLTLALDQAGMQ---FGGRPVELIIEDSAGQPEQ----AIT 110 (423) T ss_dssp -----CCEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHTTTE---ETTEEEEEEEEECTTCHHH----HHH T ss_pred cccCCCCEEEEEEECCCCCch----------hHhHHHHHHHHHHHHHhccc---cCCEEEEEEEEcCCCCHHH----HHH Confidence 345677899999999875421 24567889999999999864 2367788888776655332 233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN--TRYDFFSRVV 196 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~--~~~~~~~~~~ 196 (908) .+++++.+ +++++++++.++.....+...+...+||+|.+....+.+... ..+++++++. T Consensus 111 ~~~~l~~~------------------~~~~~iig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 172 (423) T 4ZPJ_A 111 KTRQLIER------------------DRVHLIAGITLSNEAAAVRDILVQAEMPTIVTNAGLQALTRDPAMRSPYLFRVS 172 (423) T ss_dssp HHHHHHHT------------------SCCSEEEECCCHHHHHHHHHHHHHTTCCEEESSCCCTHHHHSTTTCCTTEEESS T ss_pred HHHHHHHh------------------cCCcEEEecCCcHHHHHHHHHHHHCCCCEEEccCCcHHHcCCcccCCCceEEee Confidence 33433321 468888888766555566777888999999987655433211 1256788888 Q NP_000836.2 197 PPDSYQAQAMVDIVT-ALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PN 274 (908) Q Consensus 197 ~~~~~~~~~~~~~l~-~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~ 274 (908) ++....++.+++++. +++|+++++++.++.++..+.+.|++.+++. ++++.....+. ....+....+++++.. .+ T Consensus 173 ~~~~~~~~~~~~~l~~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~~~~~~~~ 249 (423) T 4ZPJ_A 173 FANGQYDAPAADYAYETLGYRRMVLHAADYAAGHEEMAAFRSRFEQA-GGEIVDEVVAP--IGTQDFGPYLQRIEQAAAE 249 (423) T ss_dssp CCTTTTTHHHHHHHHHTTCCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCSCCHHHHHHHHHHGGG T ss_pred cCcccchHHHHHHHHHHhCCCEEEEEEeCcHHHHHHHHHHHHHHHHc-CCEEceEEecC--CCCCChHHHHHHHHHHHcC Confidence 888888888888884 4589999999866667777788888888775 35544322222 1123344556666521 26 Q NP_000836.2 275 ARAVIMFA-NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANN 353 (908) Q Consensus 275 ~~viv~~~-~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~ 353 (908) +++|++.. .+..+..+++++++.|+..++.+++.+.+...... ........+.+...... . .... T Consensus 250 ~~~ii~~~~~~~~~~~~~~~~~~~g~~~~~~ii~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~---~~~~ 315 (423) T 4ZPJ_A 250 ADAVFAFHGTSTDAIRFLVQYQEFGLKDSIPLIPSGADVDQSIL-PEIGDAALGLVSGTLYT----------A---YNDT 315 (423) T ss_dssp CSEEEEECCSSHHHHHHHHHHHHTTCTTTSCEEECGGGGCTTTH-HHHGGGGTTCEEEESCC----------T---TCCS T ss_pred CCEEEEEcCChHHHHHHHHHHHHcCCCCCCcEecCCcccChhHH-HHHHHhhcceeEeeccc----------c---CCCC Confidence 78887664 35567788888888887533455555433221100 00111122222111100 0 0001 Q NP_000836.2 354 RRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPR 433 (908) Q Consensus 354 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~ 433 (908) +....|.+.|++.+.. ..+..++..+||+++++++|+++.... T Consensus 316 ~~~~~f~~~~~~~~~~--------------------------~~~~~~~~~~yda~~~l~~al~~~~~~----------- 358 (423) T 4ZPJ_A 316 PESQEFVEAFTARHEG--------------------------ILPGLVDYAGYIGGRVIAEALTAIDGE----------- 358 (423) T ss_dssp HHHHHHHHHHHHHTTT--------------------------CCCCHHHHHHHHHHHHHHHHHHHTTTC----------- T ss_pred HHHHHHHHHHHHHhCC--------------------------CCCChhhHHHHHHHHHHHHHHHHcCCC----------- Confidence 1112232222222110 012345678999999999999886431 Q NP_000836.2 434 MSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQY 476 (908) Q Consensus 434 ~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~ 476 (908) ..+++.+.+.|++..|.|.+| ++.|+++|++. ..+.++++ T Consensus 359 --~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~~~~~ 399 (423) T 4ZPJ_A 359 --VENKEALLEALKAVEFTGPAG-NFRFHPESQGPVTTILLCRV 399 (423) T ss_dssp --TTCHHHHHHHHHHCEEEETTE-EEEECTTTCSEEEEEEEEEE T ss_pred --CCCHHHHHHHHHcCCcccCCe-eEEECCCCCCceeeEEEEEE Confidence 124556778888888999988 89999887653 33444433 No 120 >6DLZ_B Glutamate receptor 2,Voltage-dependent calcium channel; Ion channel, TRANSPORT PROTEIN; HET: GLU, CYZ; 3.9A {Rattus norvegicus} Probab=99.37 E-value=5.2e-17 Score=198.52 Aligned_cols=356 Identities=15% Similarity=0.186 Sum_probs=226.0 Template_Neff=11.100 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~~~~ 122 (908) ++++||+++|.++. ....|++.|++++|++ |+++++...|+. +++.. +.+.+++ T Consensus 1 ~~i~IG~~~~~~~~----------------~~~~g~~~A~~~iN~~-----g~~i~l~~~d~~~~~~~~----a~~~~~~ 55 (1031) T 6DLZ_B 1 NSIQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFA----VTNAFCS 55 (1031) T ss_dssp CCEEEEEEECTTCH----------------HHHHHHHHHHHHSCCS-----SCCEEEEEEECCSSCHHH----HHHHHHH T ss_pred CceeeeeeeCCCCh----------------HHHHHHHHHHHHhhcC-----CceeccceEecCCCCHHH----HHHHHHH Confidence 36899999998642 4678999999999985 477888888876 44322 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. +++++++|+.++....+++..+...++|++++..++. ..+++++++.|+. T Consensus 56 l~~-------------------~~v~aviG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~~--- 108 (1031) T 6DLZ_B 56 QFS-------------------RGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPDL--- 108 (1031) T ss_dssp HHH-------------------HTCSCEEECCCTTTHHHHHHHHHHHCCCEEECSSCCS-----SCCTTEEECSCCC--- T ss_pred HHh-------------------cCeeEEEecCChHHHHHHHHHHhccCCcEEEcCCCCC-----CCCCeEEEeeccH--- Confidence 332 5799999998887777888889999999998875433 2478899998873 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPR--EPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) +.++++++++++|+++++++ +++++....+.+.+.+++. ++++.....+.. +.+..++.+.++++++ .++|+|++ T Consensus 109 ~~~~~~~l~~~~~~~v~ii~-~~~~g~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~d~~~~~~~i~~-~~~~~vv~ 185 (1031) T 6DLZ_B 109 KGALLSLIEYYQWDKFAYLY-DSDRGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKERRVIL 185 (1031) T ss_dssp HHHHHHHHHHHTCSEEEEEE-CGGGCSHHHHHHHHHHHHT-TCEEEEEECTTCCSTTTTTHHHHHHHHHTT-TTCCEEEE T ss_pred HHHHHHHHHHhCCCEEEEEE-eCcchHHHHHHHHHHHhhc-CCeEEEEEecCCCCCCCcchhHHHHHHHcc-cCceEEEE Confidence 67778888888999999999 6678887788888877765 455543332210 0123456677777764 57899988 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) ......+..+++++++.|+.. .+.|+..+........ ........+....... ....+....+ T Consensus 186 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~---------------~~~~~~~~~f 249 (1031) T 6DLZ_B 186 DCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGAEVSGFQIV---------------DYDDSLVSKF 249 (1031) T ss_dssp ECCHHHHHHHHHHHHHHTCCSTTCEEEECSSBTTTSCC-SSSSSSSCEEEEEESC---------------CTTSHHHHHH T ss_pred ECCHHHHHHHHHHHHHhCCccCCcEEEEEeCCCCcCcH-HHhccCCceEEEEEEe---------------eCCcHHHHHH Confidence 877777888999999988854 3566665422211100 0000111111111000 0001112223 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~~~~- 434 (908) .+.+++.++..... . ....++.++..+||+++++++|++++...... .....|... T Consensus 250 ~~~~~~~~~~~~~~-------------~------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~~~~~~ 310 (1031) T 6DLZ_B 250 IERWSTLEEKEYPG-------------A------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANP 310 (1031) T ss_dssp HHHHHTSCTTTSTT-------------C------SSSCCCHHHHHHHHHHHHHHHHHHHHHHTTCCCCCCSCCCCTTCTT T ss_pred HHHHHhcccccCCC-------------C------CcCCCcHHHHHHHHHHHHHHHHHHHHHHcccccccCCCCCCCccCC Confidence 33333322210000 0 00123456788999999999999998653210 000112110 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ...+++.+.++|++..|.|..| ++.|+++|++.. .+.+++++ ++.+..+|.|+.. T Consensus 311 ~~~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~~~~~~~~ 368 (1031) T 6DLZ_B 311 AVPWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEV 368 (1031) T ss_dssp CCCCTHHHHHHHHHTTCCCEETTE-ECEECSSSCEESCEEEEEEEC----SSCEEEEEEEESS T ss_pred CCCcccHHHHHHHHHhcCccCCCc-cEEeCCCCcEEeeEEEEEEec----cCCcEEEEEEeCC Confidence 1224667888888888999888 899999888764 78888887 3568888888754 No 121 >3EAF_A ABC transporter, substrate binding protein; 11229a2, PSI2, NYSGXRC, ABC transporter; 2.0A {Aeropyrum pernix} Probab=99.36 E-value=6.6e-17 Score=173.99 Aligned_cols=362 Identities=14% Similarity=0.105 Sum_probs=213.9 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLL-SNI--TLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il-~g~--~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) .++++||+++|.++.. ...+.....|++.|++++|..++++ +|+ ++++.+.|+.+++. ...+. T Consensus 2 ~~~~~Ig~i~~~~~~~----------~~~~~~~~~g~~~a~~~~n~~g~~~~~g~~~~v~~~~~d~~~~~~----~~~~~ 67 (391) T 3EAF_A 2 SLTINVGLLVDETGPT----------SDVGKGYSLGAELAFKYFNEKGIYTKDGVRVNINYIKRDYAYNPT----TAEEY 67 (391) T ss_dssp CEEEEEEEEECSSSTT----------HHHHHHHHHHHHHHHHHHHHHCEECTTCCEEEEEEEEEECTTCHH----HHHHH T ss_pred CCeEEEEEEecCCCCc----------chhchhhHHHHHHHHHHHHhcCceeeCCceeEEEEEEecCCCCHH----HHHHH Confidence 4578999999976532 1356678899999999999765432 344 56666677655432 22333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++++. +.++++||++ ++.....+...+...++|+|.+....+.+ .+++++++.+++ T Consensus 68 ~~~l~~------------------~~~v~~ii~~-~~~~~~~~~~~~~~~~ip~i~~~~~~~~~----~~~~~~~~~~~~ 124 (391) T 3EAF_A 68 YREFRD------------------RYGVIAIIGW-GTADTEKLSDQVDTDKITYISASYSAKLL----VKPFNFYPAPDY 124 (391) T ss_dssp HHCCCC------------------CTCCSEEEEC-CHHHHHHHHHHHHHHTCEEEESCCCGGGT----TSTTEECSSCCH T ss_pred HHHHHH------------------hcCceEEEec-ccHHHHHHHHHHHHcCCeEEEcCcchhhc----CCCceeecCCCH Confidence 333332 1478999986 55555566677888999999987654322 246778888888 Q NP_000836.2 200 SYQAQAMVDIV-TALGWNYVSTLAS-EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 200 ~~~~~~~~~~l-~~~~~~~v~ii~~-~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ...+..+++++ ++++|+++++++. ++.++..+.+.|++.+++. ++++.....+.......+....+++++. .++++ T Consensus 125 ~~~~~~~~~~l~~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~ 202 (391) T 3EAF_A 125 STQACSGLAFLASEFGQGKLALAYDSKVAYSRSPIGAIKKAAPSL-GLQVVGDYDLPLRATEADAERIAREMLA-ADPDY 202 (391) T ss_dssp HHHHHHHHHHHHHHHCSEEEEEEECTTCHHHHTTHHHHHHHTGGG-TEEEEEEEECCTTCCHHHHHHHHHHHHT-TCCSE T ss_pred HHHHHHHHHHHHHHhCCCeEEEEEcCCCccccCHHHHHHHHHHHc-CCEEEEeeecCCCCCcccHHHHHHHHHH-cCCCE Confidence 88888888887 5679999999985 5566777788888887765 3554332111110112334555666653 47888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTI-LPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) +++...+..+..+++++++.|+. .+|+..+ |...............+.+.. ... .........+.. T Consensus 203 vi~~~~~~~~~~~~~~~~~~g~~--~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~----------~~~~~~~~~~~~ 269 (391) T 3EAF_A 203 VWCGNTISSCSLLGRAMAKVGLD--AFLLTNV-WGFDERSPQLIGEGGYGKVFGISPF----------IYPMFGQDVEGI 269 (391) T ss_dssp EEECSCHHHHHHHHHHHHHHTCC--CEEEECG-GGCSTTHHHHHCGGGTTSEEEEESB----------CCGGGCTTCHHH T ss_pred EEECCCHHHHHHHHHHHHHcCCC--cEEEecc-ccCCccchHHhccccccceeeeecc----------ccccCCcCCHHH Confidence 87765666777889999888874 3455443 221110000001111221110 000 000000001111 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMST 436 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~ 436 (908) ..|.+.+++ +... ...+..++..+||+++++++|++++..... .. T Consensus 270 ~~f~~~~~~-~~~~------------------------~~~~~~~~~~~yda~~~~~~al~~~~~~~~----------~~ 314 (391) T 3EAF_A 270 QTIFEAARM-NGVS------------------------EDQINLRVVQGFVNVWLLIKAIESVTSQDL----------QE 314 (391) T ss_dssp HHHHHHHHH-TTCC------------------------GGGCCHHHHHHHHHHHHHHHHHTTSCHHHH----------HH T ss_pred HHHHHHHHH-cCCC------------------------cccCChhHHHHHHHHHHHHHHHHHhccccc----------cc Confidence 122222222 1100 011235677899999999999998753210 01 Q NP_000836.2 437 IDGKELLGYIRAVNFN--GSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 437 ~~~~~l~~~l~~~~f~--G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .+++.+.++|++..|. |.+|+++.|+++|++. ..+.+.+++. ++.++.++.|... T Consensus 315 ~~~~~l~~~l~~~~~~~~G~~g~~i~f~~~~~~~~~~~~i~~~~~---~~~~~~v~~~~~~ 372 (391) T 3EAF_A 315 RGGEALKEALEANTFDLGGITADTIDYEPGFHLAYRKVFIIKLGE---NGELQLMGKFEAP 372 (391) T ss_dssp HTHHHHHHHHHHCCBCSTTCBSSCBCCBTTBCCCCCCEEEEEECT---TSSEEEEEEECCC T ss_pred cChHHHHHHHHhCCCCCCCccccceEecCCCccccceEEEEEECC---CCeEEeCcceeCc Confidence 2456778888877787 7765469999877653 4566666652 2467888888754 No 122 >5UOW_C N-methyl-D-aspartate receptor subunit NR1-8a, N-methyl-D-aspartate; membrane protein; HET: NAG, GLU, BMK; 4.5A {Xenopus laevis} Probab=99.36 E-value=6.8e-17 Score=192.22 Aligned_cols=336 Identities=18% Similarity=0.285 Sum_probs=221.7 Template_Neff=11.300 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.+ ....|++.|++++|+++ .+.++++.+.|+..++.. ...+.+.+++ T Consensus 2 ~~~i~Ig~~~p~~------------------~~~~~~~~a~~~~n~~g---~~~~i~l~~~d~~~~~~~-~~~~~~~~~~ 59 (814) T 5UOW_C 2 PKIVNIGAVLSTK------------------KHEQIFREAVNQANKRH---FTRKIQLNATSVTHRPNA-IQMALSVCED 59 (814) T ss_dssp CSCEEEEEEESCH------------------HHHHHHHHHHHHHHHHS---CTTTCCEEEEEEECCSSH-HHHHHCCCCC T ss_pred CCccceEEEecCc------------------hHHHHHHHHHHHHHHhc---cCCCeeeeceeecCCCCH-HHHHHHHHHH Confidence 4678999999865 24578999999999865 246677777776544322 1112333333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-----IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-----~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +.. +++++++|+.++..+ ..++..+...++|++++.+..+.+.+...+++++++.+ T Consensus 60 l~~-------------------~~v~~iig~~~~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~~~~ 120 (814) T 5UOW_C 60 LIS-------------------SQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVP 120 (814) T ss_dssp TTT-------------------TCCSCEEECCCSSCCSSCTTSHHHHHHHHHTCCEEESSCCCGGGCCTTTCSSEEESSC T ss_pred HHh-------------------cCceEEEEcCCCCCCCCCCCchhHHhhhhcCCCEEEccCCCccccCCccCchhhcCCC Confidence 322 478899998877766 56667888899999998876665544335788999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ++...++++++++++++|+++++++.+++++....+.+++.+++. ++++.....+. .+..++...++++++ .++|+ T Consensus 121 ~~~~~~~~~~~~~~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~l~~-~~~~~ 196 (814) T 5UOW_C 121 PYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEK-ESKADKVLQFE--PGTKNLTALLLEAKE-LEARV 196 (814) T ss_dssp CTTTHHHHHHHHHHHHTCCCCEEEEESSHHHHHHHHHHHHHHHHS-SCCCSCEEEEC--SSCSCCHHHHHHHHH-SSCCE T ss_pred CHHHHHHHHHHHHHHcCCcEEEEEEecCcchHHHHHHHHHHHHhc-ccccceeeccC--CCCccHHHHHHHHHh-cCCeE Confidence 999999999999988899999999987788888888888888775 45554333232 223456667777763 57899 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) |++.+.......+++++++.|+.. .+.|++.+.+.... .......+.+.. T Consensus 197 vv~~~~~~~~~~~l~~~~~~g~~~~~~~~~~~~~~~~~~----~~~~~~~~~~~~------------------------- 247 (814) T 5UOW_C 197 IILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGS----ALRYAPDGIIGL------------------------- 247 (814) T ss_dssp EEEECCHHHHHHHHHHHHHTTTTSTTCEEEECHHHHSTH----HHHTCCTTCEEE------------------------- T ss_pred EEEeCCHHHHHHHHHHHHhcCCCCCCeEEEEecCCCCCc----hhhcCCCceEEE------------------------- Confidence 888877777788899988888753 34555543221110 000000000000 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGY-IGLCPRM- 434 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~-~~~~~~~- 434 (908) . . ..+..++..+|||++++++++++.....+... ...|... T Consensus 248 ----~----~-----------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~~~~~~~~~~~~~~~ 290 (814) T 5UOW_C 248 ----Q----L-----------------------------INGKNESAHISDAVAVVAQAIHELFEMEQITDPPRGCVGNT 290 (814) T ss_dssp ----E----E-----------------------------SSSSCHHHHHHHHHHHHHHHHHHHTTSCCCCCCCSSSTTCC T ss_pred ----E----e-----------------------------cCCCcchhHHHHHHHHHHHHHHHHHhcCCCCCCCCCcCCCC Confidence 0 0 00123456789999999999998765422110 0112111 Q NP_000836.2 435 -STIDGKELLGYIRAV-NFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 435 -~~~~~~~l~~~l~~~-~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ...++..+.+.+++. .|+|.+| ++.||++|++. ..+.+.+++ ++.+..+|.|+.. T Consensus 291 ~~~~~~~~l~~~l~~~~~~~G~~g-~~~fd~~g~~~~~~~~i~~~~----~~~~~~v~~~~~~ 348 (814) T 5UOW_C 291 NIWKTGPLFKRVLMSSKYPDGVTG-RIEFNEDGDRKFAQYSIMNLQ----NRKLVQVGIFDGS 348 (814) T ss_dssp SCCSSSHHHHHHHHTCCCCCCSSC-CCCBCTTSCBCCCCEEEEECC----TTSCEEEEEECSS T ss_pred ccccchHHHHHHHHhcCCCCCccc-ceEECCCCceeeeEEEEEEcc----CCceEEEEEEeCC Confidence 012445677777754 6788888 89999999875 678888886 3578999999864 No 123 >3LOP_A Substrate binding periplasmic protein; Substrate-binding, Protein Structure Initiative II(PSI; HET: EDO; 1.55A {Ralstonia solanacearum} Probab=99.36 E-value=7.1e-17 Score=171.86 Aligned_cols=352 Identities=11% Similarity=0.091 Sum_probs=207.6 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||+++|.++... ..+.....+++.|++++|+++++. |+++++...|+.+++. ...+.+++ T Consensus 3 ~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~g~~~-g~~v~~~~~d~~~~~~----~~~~~~~~ 67 (364) T 3LOP_A 3 LADISVIQSLPLSGSQA----------VTGRALNAGARLYFDWLNLNGGIN-GETIRLVARDDEQKIE----QTVRNVRD 67 (364) T ss_dssp --CEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHHHHTTTBT-TBCEEEEEEECTTCHH----HHHHHHHH T ss_pred cccEEEEEecCCCCCch----------HHhHHHHHHHHHHHHHHHHcCCcC-CEEEEEEEecCCCCHH----HHHHHHHH Confidence 46789999999865321 245678899999999999876543 6778887777655532 22333333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVA--NILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va--~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++. ..++++++++.++....... ..+...++|+|.++...+.+. ..++++++.++.. T Consensus 68 l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~---~~~~~~~~~~~~~ 126 (364) T 3LOP_A 68 MAR------------------VDNPVALLTVVGTANVEALMREGVLAEARLPLVGPATGASSMT---TDPLVFPIKASYQ 126 (364) T ss_dssp HHH------------------HSCEEEEECCCCHHHHHHHHHTTHHHHHTCCEESCSCCCGGGG---SCTTEECCSCCHH T ss_pred HHh------------------hcCceEEEEecCCHHHHHHHhhhhHHhcCCCEEeccCCCcccC---CCCceEEccCCHH Confidence 332 14788888876655444443 567788999998876554332 1467788888888 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ..++.+++++.+.+|++|++++.++.++..+.+.+++.+++. ++++.....+. ....+....+++++. .++++|++ T Consensus 127 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~ 202 (364) T 3LOP_A 127 QEIDKMITALVTIGVTRIGVLYQEDALGKEAITGVERTLKAH-ALAITAMASYP--RNTANVGPAVDKLLA-ADVQAIFL 202 (364) T ss_dssp HHHHHHHHHHHHTTCCCEEEEEETTHHHHHHHHHHHHHHHTT-TCCCSEEEEEC--TTSCCCHHHHHHHHH-SCCSEEEE T ss_pred HHHHHHHHHHHHhCCCEEEEEEecCchhHHHHHHHHHHHHHC-CCceeEEeeeC--CCCCChHHHHHHHHh-CCCCEEEE Confidence 888889998877899999999966667777888888888775 35544322221 122344555666653 47888777 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQE-EIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~-~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) ...+..+..+++++++.|+. ..+++.+.+...... .... ....+....... ........+....| T Consensus 203 ~~~~~~~~~~~~~~~~~g~~--~~ii~~~~~~~~~~~-~~~~~~~~~~~~~~~~~-----------~~~~~~~~~~~~~f 268 (364) T 3LOP_A 203 GATAEPAAQFVRQYRARGGE--AQLLGLSSIDPGILQ-KVAGLDAVRGYSLALVM-----------PNPGKSVNPVIREF 268 (364) T ss_dssp ESCHHHHHHHHHHHHHTTCC--CEEEECTTSCHHHHH-HHHCHHHHTTCEEEECS-----------CCTTCTTSHHHHHH T ss_pred ECCHHHHHHHHHHHHHCCCC--ceEEEecCCChHHHH-HHhCccccccEEEEEEe-----------cCCCcCCCHHHHHH Confidence 76566677888888887773 456665543321110 0000 011221110000 00000001111223 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDG 439 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~ 439 (908) .+.+++.+.. ...++.++..+||++++++.|+++.... .++ T Consensus 269 ~~~~~~~~~~-------------------------~~~~~~~~~~~yda~~~~~~a~~~~~~~--------------~~~ 309 (364) T 3LOP_A 269 NRARAAVGAK-------------------------DVDLSFRAVEGFVAAKVLAEAIRRAGPK--------------PTR 309 (364) T ss_dssp HHHHHHHTCT-------------------------TCCCCHHHHHHHHHHHHHHHHHHHHCSS--------------CCH T ss_pred HHHHHHhCCC-------------------------CCCCCHHHHHHHHHHHHHHHHHHHHCCC--------------CCH Confidence 3222221110 0112345778999999999999886421 234 Q NP_000836.2 440 KELLGYIRAV-NFNGS-AGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 440 ~~l~~~l~~~-~f~G~-~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) +.+.++|++. .|... .+ ++.|++++++. ..+.+++++ .+.++.++.|+ T Consensus 310 ~~~~~~l~~~~~~~~~g~~-~~~f~~~~~~~~~~~~~~~~~----~~~~~~~~~~~ 360 (364) T 3LOP_A 310 EQVRHALTELRDYDVGGGF-TVDFTDRSRPGSHYIELGVVG----PNGLVIQEGHH 360 (364) T ss_dssp HHHHHHHHTCEEEESSTTC-EEECSSTTSCSCCCCEEEEEC----TTSCEEEC--- T ss_pred HHHHHHHHhCCCCcCCCCe-eeecCCCCCcccCeEEEEEEC----CCceEeecCCC Confidence 5677777664 46421 23 68888766543 456666666 24566677665 No 124 >5IOV_B GluN1, GLY-GLY-GLU-GLU; ligand-gated ion channel, synaptic transmission; HET: QEM, GLU, GLY; 7.5A {Xenopus laevis} Probab=99.35 E-value=7.4e-17 Score=192.20 Aligned_cols=341 Identities=15% Similarity=0.193 Sum_probs=215.4 Template_Neff=11.300 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPD--LLSNITLGVRILDTCSRDTYALEQS 116 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~--il~g~~l~~~~~d~~~~~~~a~~~~ 116 (908) .....++++||+++|.++ . ++|++++|++++ .+++..+.+.+.|+.+++..+.+ T Consensus 23 ~~~~~~~i~Ig~~~~~~g-------------~---------~~A~~~iN~~~g~~~~~~~~~~~~~~d~~~~~~~~~~-- 78 (825) T 5IOV_B 23 YAQKHPNMDIAVILVGTT-------------E---------EVAIKDVHEKDDFHHLPVTPRVELVTMQESDPKSIIT-- 78 (825) T ss_pred HHhhCCCCcEEEEEecCc-------------e---------eeeecccccCCCcccCCCCceeeEecCCCCCHHHHHH-- Confidence 356678999999999763 1 889999998876 44454455555666655443333 Q NP_000836.2 117 LTFVQALIEKDASDVKCANGDPPIFTKPDKISGVI-GAAASS--VSIMVANILRLFKIPQISYASTAPE-LSDNTRYDFF 192 (908) Q Consensus 117 ~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~--~~~~va~~~~~~~iP~Is~~~~~~~-l~~~~~~~~~ 192 (908) .+++++. .+++++++ |+.++. .+..++..+...++|+|++.+..+. +++...++++ T Consensus 79 --~~~~l~~------------------~~~v~avi~G~~~s~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~ 138 (825) T 5IOV_B 79 --RICDLMS------------------DKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMF 138 (825) T ss_pred --HHHHhcc------------------cCCcEEEEEcCCCChHHHHHHHHHHHHhhCCCEEEecCCCccccccccCCeeE Confidence 3333332 14788876 987765 4456667777899999996544332 2222357889 Q NP_000836.2 193 SRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREP-RPGEFEKIIKRLLE 271 (908) Q Consensus 193 ~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~-~~~~~~~~~~~l~~ 271 (908) +++.|++...+.++++++.+++|+++++++.+++++....+.+++.+++. +.++.....+..+. ...+....++++++ T Consensus 139 ~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 217 (825) T 5IOV_B 139 FQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRSTIENS-FVGWELEEVIHLDMSLDDIDSKIQNQLKK 217 (825) T ss_pred EEcCCCHHHHHHHHHHHHHHcCCeEEEEEEEcCCCchhHHHHHHHHHHhc-cCceEEEEEEEccCChhhHHHHHHHHHHh Confidence 99999998889999999988899999999987778888888888877764 34443222221100 12234455555653 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTL 350 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~ 350 (908) .++|+|++.+....+..+++++++.|+.. ++.|+..+.+...... .......+.. T Consensus 218 -~~~~~iv~~~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~--------------------- 273 (825) T 5IOV_B 218 -LQSPVILLYCTKEEATYIFEVAHSVGLTGYGFTWIVPSLVAGDTDT--VPDEFPTGLI--------------------- 273 (825) T ss_pred -cCCCEEEEECCHHHHHHHHHHHHHcCCCCCCeEEEeeecCCCCCCC--CCCcCCCCeE--------------------- Confidence 47899888777777888999998888753 3456654432211000 0000000000 Q NP_000836.2 351 ANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG--YI 428 (908) Q Consensus 351 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~--~~ 428 (908) .. .+. ..+..++..+|||++++++|++++....+.. .. T Consensus 274 --------~~-----~~~---------------------------~~~~~~~~~~yDav~~~a~al~~~~~~~~~~~~~~ 313 (825) T 5IOV_B 274 --------SV-----SYD---------------------------EWDYDLPARVRDGIAIITTAASTMLSEHNSIPQSK 313 (825) T ss_pred --------EE-----Eee---------------------------cCCCCcchhHHHHHHHHHHHHHHHHHhcCCCCCCC Confidence 00 000 0012346789999999999999986542110 00 Q NP_000836.2 429 GLCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 429 ~~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ..|... ...++..+.+.|++.+|.| | ++.|+++|++. ..+.+++++. ++.+..+|.|... T Consensus 314 ~~~~~~~~~~~~~~~~l~~~l~~~~f~G--G-~~~f~~~g~~~~~~~~i~~~~~---~~~~~~~~~~~~~ 377 (825) T 5IOV_B 314 SSCNNIQESRVYEAHMLKRYLINVTFEG--R-DLSFSEDGYQMHPKLVIILLNQ---ERKWERVGKYKDR 377 (825) T ss_pred cccccCCcchhHhHHHHHHHHhcccccC--c-ceeeCCCCccceeeEEEEEeCC---CCceEEEEEEeCC Confidence 122211 1124567888888889988 7 89999999884 5778888863 2568888888654 No 125 >5WEO_A Glutamate receptor 2,Voltage-dependent calcium channel; Ion channel, TRANSPORT PROTEIN; HET: CYZ, GLU;{Rattus norvegicus} Probab=99.33 E-value=1.3e-16 Score=194.97 Aligned_cols=356 Identities=15% Similarity=0.187 Sum_probs=224.0 Template_Neff=11.100 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~~~~ 122 (908) ++++||+++|.++. ....|++.|++++|++ |+++++...|+. +++.. +.+.+++ T Consensus 1 ~~i~Ig~~~~~sg~----------------~~~~~~~~a~~~iN~~-----g~~l~~~~~d~~~~~~~~----a~~~~~~ 55 (1034) T 5WEO_A 1 NSIQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFA----VTNAFCS 55 (1034) T ss_dssp CEEEEEEEECTTCH----------------HHHHHHHHHHHHHCCS-----SSEEEEEEEECCSSCHHH----HHHHHHH T ss_pred CceeeeeeecCCCh----------------HHHHHHHHHHHhhhcC-----CceeeeeeEecCCCCHHH----HHHHHHH Confidence 36899999998752 5678999999999985 477888888876 44332 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) +++ +++++++|+.++....+++..+.+.++|++++...++ ..+++++++.|+. T Consensus 56 l~~-------------------~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~~--- 108 (1034) T 5WEO_A 56 QFS-------------------RGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPDL--- 108 (1034) T ss_dssp HHH-------------------HTCSEEEECCCTTTHHHHHHHHHHHCCCEEECSSCCS-----SCCTTEEECCCCC--- T ss_pred HHH-------------------cCeeEEEecCChHHHHHHHHHHcccCCeEEeCCCCCC-----CCCCeEEEecCch--- Confidence 332 5789999998887777888888899999998875433 2468899998873 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPR--EPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) +.++++++++++|+++++++ +++++....+.+.+.+++. ++++.....+.. +.+..++.+.++++++ .++|+|++ T Consensus 109 ~~~~~~~l~~~~~~~v~iv~-~~~~g~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~d~~~~~~~i~~-~~~~~vv~ 185 (1034) T 5WEO_A 109 KGALLSLIEYYQWDKFAYLY-DSDRGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKERRVIL 185 (1034) T ss_dssp HHHHHHHHHHHTCSEEEEEE-CGGGCSHHHHHHHHHHHHT-TCEEEEEECTTSCGGGTTHHHHHHHHHHTT-TTCCEEEE T ss_pred HHHHHHHHHHhCCCEEEEEE-eCCchHHHHHHHHHHHhhc-CCeEEEEEecCCCCCCCccchHHHHHHHhh-cCCcEEEE Confidence 56777888788999999999 6677777777788777764 455543322210 0122456677777764 57899988 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) ......+..+++++++.|+.. .+.|++.+.+...... ........+....... ....+....+ T Consensus 186 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~---------------~~~~~~~~~f 249 (1034) T 5WEO_A 186 DCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGAEVSGFQIV---------------DYDDSLVSKF 249 (1034) T ss_dssp ESCHHHHHHHHHHHHHHTTTSTTCEEEECSSBTTSSCC-STTTTSSSEEEEEESS---------------CTTSHHHHHH T ss_pred eCCHHHHHHHHHHHHHhCCCcCCeEEEEEeCCCCCCch-HhcccCCceEEEEEEe---------------eCCcHHHHHH Confidence 877777888999999988854 3556665422211100 0000001111111000 0011122223 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~~~~- 434 (908) .+.+++.++..... . ....++.++..+|||++++++|++++...... .....|... T Consensus 250 ~~~~~~~~~~~~~~---------~----------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~~~~~~ 310 (1034) T 5WEO_A 250 IERWSTLEEKEYPG---------A----------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANP 310 (1034) T ss_dssp HHHHHTSCTTTSTT---------C----------SSSSCCHHHHHHHHHHHHHHHHHHHHHHTTCCCCCCSCCCCTTCTT T ss_pred HHHHHhcccccCCC---------c----------CCCCCchHHHHHHHHHHHHHHHHHHHHHhccccccCCCCCCCccCC Confidence 33333332210000 0 00123456788999999999999998643210 000112110 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ...+++.+.+++++..|.|..| ++.|+++|++.. .+.+.+++ ++.+..+|.|... T Consensus 311 ~~~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~i~~~~----~~~~~~~~~~~~~ 368 (1034) T 5WEO_A 311 AVPWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEV 368 (1034) T ss_dssp CCCCTHHHHHHHHHTTCCCEETTE-ECEECTTSCEESCEEEEEEEC----SSSEEEEEEEESS T ss_pred CCCcccHHHHHHHHHhcCcCCCCC-ceEeCCCCcEEeeEEEEEEec----cCCceEEEEEeCC Confidence 1224667888888888999888 899998888754 67888887 3567888888753 No 126 >4DQD_A Extracellular ligand-binding receptor; structural genomics, PSI-Biology, protein structure; HET: PPY, PG4, GOL; 1.601A {Rhodopseudomonas palustris} Probab=99.31 E-value=1.9e-16 Score=168.26 Aligned_cols=348 Identities=14% Similarity=0.130 Sum_probs=203.5 Template_Neff=12.200 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.++... ..+.....+++.+++++| |.++++.+.|+..++.. ..+.+++ T Consensus 2 ~~~~~Ig~~~~~~~~~~----------~~~~~~~~g~~~a~~~~~-------g~~~~~~~~~~~~~~~~----~~~~~~~ 60 (363) T 4DQD_A 2 NAEIKIGITMSASGPGA----------ALGQPQSKTVAALPKEIG-------GEKVTYFALDDESDPTK----AAQNARK 60 (363) T ss_dssp -CCEEEEEEECCSSTTH----------HHHHHHHHHGGGSCSEET-------TEEEEEEEEECTTCHHH----HHHHHHH T ss_pred CcceEEEEEEcCCCCch----------hcChhhHHHHHHchHhhC-------CEEEEEEEEcCCCCHHH----HHHHHHH Confidence 35789999999865321 245667888888888875 35577777776555332 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELS-DNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~-~~~~~~~~~~~~~~~~~ 201 (908) ++. .++++++|++.++.....+...+...++|+|......+.+. .....++++++.++... T Consensus 61 l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 122 (363) T 4DQD_A 61 LLS------------------EEKVDVLIGSSLTPVSLPLIDIAAEAKTPLMTMAAAAILVAPMDERRKWVYKVVPNDDI 122 (363) T ss_dssp HHH------------------TSCCSEEECCSSHHHHHHHHHHHHHTTCCEEECCCCGGGTCSCCTTGGGEEECSCCHHH T ss_pred HHh------------------hcCCCEEEecCCchhHHHHHHHHHHcCCCEEEccCccccccCcccccCceeEecCCHHH Confidence 332 14789999877665555666777888999998876554322 11134677888898888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. ....+....+++++. .++|++++. T Consensus 123 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i~~~ 198 (363) T 4DQD_A 123 MAEAIGKYIAKTGAKKVGYIGFSDAYGEGYYKVLAAAAPKL-GFELTTHEVYA--RSDASVTGQVLKIIA-TKPDAVFIA 198 (363) T ss_dssp HHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHH-TCEECCCEEEC--TTCSCCHHHHHHHHH-TCCSEEEEE T ss_pred HHHHHHHHHHHhCCCeEEEEEecCcchHHHHHHHHHHHHHc-CcEEeeeeeeC--CCCCccHHHHHHHHh-hCCCEEEEe Confidence 88899999877799999999966667778888888888775 35544322222 112334555666653 578888877 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTL-ANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~ 360 (908) .....+..+++++++.|+. .+|++.+.+...... ........+.+..... +......... ...+....|. T Consensus 199 ~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~------~~~~~~~~~~~~~~~~~~~f~ 269 (363) T 4DQD_A 199 SAGTPAVLPQKALRERGFK--GAIYQTHGVATEEFI-KLGGKDVEGAIFAGEA------FSGAEDMPADSPFRKVKARFV 269 (363) T ss_dssp CCSGGGHHHHHHHHHTTCC--SEEECCGGGCSHHHH-HHHGGGGTTCEEEECH------HHHGGGSCTTCHHHHHHHHHH T ss_pred cCCccchHHHHHHHHcCCC--ceEEecccccCHHHH-HhhcccccccEEeccc------ccCCCCCCCCCchhHHHHHHH Confidence 6555577888888888874 355555433322110 0001112232211100 0000000000 0000111122 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++ ...++.++..+||++++++.+++++....... ...++. T Consensus 270 ~~~~~~~~--------------------------~~~~~~~~~~~yda~~~~~~a~~~~~~~~~~~--------~~~~~~ 315 (363) T 4DQD_A 270 DAYKAANG--------------------------GAAPTIFGVHLWDSMTLVENAIPAALKAAKPG--------TPEFRA 315 (363) T ss_dssp HHHHHHTT--------------------------TCCCCTHHHHHHHHHHHHHHHHHHHHHHCCTT--------SHHHHH T ss_pred HHHHHHcC--------------------------CCCCCCccccHHHHHHHHHHHHHHHHHhcCCC--------CHHHHH Confidence 22221110 01234567889999999999998875431100 112455 Q NP_000836.2 441 ELLGYIRAV-NFNGSAGTPVTFNENG---DAPGRYDIFQYQ 477 (908) Q Consensus 441 ~l~~~l~~~-~f~G~~G~~v~Fd~~G---~~~~~~~i~~~~ 477 (908) .+.+.|++. .|.|.+| .+.|+..+ .+...+.+++++ T Consensus 316 ~l~~~l~~~~~~~g~~g-~~~~~~~~~~~~~~~~~~i~~~~ 355 (363) T 4DQD_A 316 AIRDQIEKSKDLALNNG-LSNMTPDNHNGYDERSAFLIEIR 355 (363) T ss_dssp HHHHHHTTCCSEEETTE-EECCCSSCSSCCCGGGCEEEEEE T ss_pred HHHHHHHhcccccccCC-ccccCCCCCCCCCccceEEEEEE Confidence 677888876 7888877 89997542 222356666665 No 127 >3SG0_A Extracellular ligand-binding receptor; structural genomics, PSI-Biology, protein structure; HET: 173, MSE; 1.201A {Rhodopseudomonas palustris} Probab=99.28 E-value=3.9e-16 Score=167.41 Aligned_cols=350 Identities=14% Similarity=0.122 Sum_probs=203.1 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||+++|.++... ..+.....+++.+++++| |+++++.+.|+.+++. ...+.+ T Consensus 23 ~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~-------g~~~~~~~~~~~~~~~----~~~~~~ 81 (386) T 3SG0_A 23 AAQAEIKIGITMSASGPGA----------ALGQPQSKTVAALPKEIG-------GEKVTYFALDDESDPT----KAAQNA 81 (386) T ss_dssp --CCCEEEEEEECCSSTTH----------HHHHHHHHHGGGSCSEET-------TEEEEEEEEECTTCHH----HHHHHH T ss_pred ccCCceEEEEEEcCCCCcc----------ccchhHHHHHHHcchhhC-------CEEEEEEEEcCCCCHH----HHHHHH Confidence 4567899999999875321 245567788888888765 3456666667654432 223333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELS-DNTRYDFFSRVVPPD 199 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~-~~~~~~~~~~~~~~~ 199 (908) ++++. .++++++|++.++.....+...+...++|+|.+....+.+. .....++++++.+++ T Consensus 82 ~~~~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~ 143 (386) T 3SG0_A 82 RKLLS------------------EEKVDVLIGSSLTPVSLPLIDIAAEAKTPLMTMAAAAILVAPMDERRKWVYKVVPND 143 (386) T ss_dssp HHHHH------------------TSCCSEEECCSSHHHHHHHHHHHHHTTCCEEECCCCGGGTCSCCTTGGGEEECSCCH T ss_pred HHHHh------------------cCCCCEEEccCCchhHHHHHHHHHHcCCCEEEcCCcccccCCcccccCceeEecCCH Confidence 43332 14788999877665555666777888999998876554322 111346788888888 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) ...++.+++++.+.+|++|++++.++.++..+.+.+++.+++. ++++.....+. ....+....+++++. .++|+++ T Consensus 144 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii 219 (386) T 3SG0_A 144 DIMAEAIGKYIAKTGAKKVGYIGFSDAYGEGYYKVLAAAAPKL-GFELTTHEVYA--RSDASVTGQVLKIIA-TKPDAVF 219 (386) T ss_dssp HHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHH-TCEECCCEEEC--TTCSCCHHHHHHHHH-TCCSEEE T ss_pred HHHHHHHHHHHHHhCCCEEEEEeecCccchhHHHHHHHHHHHc-CCEEeeeEeeC--CCCCChHHHHHHHHh-hCCCEEE Confidence 8888899999877799999999966667778888888888775 35543322221 122345556666663 4788887 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTL-ANNRRNVW 358 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~ 358 (908) +......+..+++++++.|+. ..|++.+.+...... ........+.+..... +......... ...+.... T Consensus 220 ~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~------~~~~~~~~~~~~~~~~~~~ 290 (386) T 3SG0_A 220 IASAGTPAVLPQKALRERGFK--GAIYQTHGVATEEFI-KLGGKDVEGAIFAGEA------FSGAEDMPADSPFRKVKAR 290 (386) T ss_dssp EECCSGGGHHHHHHHHHTTCC--SEEECCGGGCSHHHH-HHHGGGGTTCEEEECH------HHHGGGSCTTCHHHHHHHH T ss_pred EecCCccchHHHHHHHHcCCC--ceEEeccccCCHHHH-HhhccccCccEEeecc------cCCCCCCCCCCchhHHHHH Confidence 776555577888888888874 355555433221110 0001112222211100 0000000000 00001111 Q NP_000836.2 359 FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTID 438 (908) Q Consensus 359 ~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~ 438 (908) |.+.+.+.+. ...+..++..+||++++++++++++...... ....+ T Consensus 291 f~~~~~~~~~--------------------------~~~~~~~~~~~yda~~~~~~a~~~~~~~~~~--------~~~~~ 336 (386) T 3SG0_A 291 FVDAYKAANG--------------------------GAAPTIFGVHLWDSMTLVENAIPAALKAAKP--------GTPEF 336 (386) T ss_dssp HHHHHHHHTT--------------------------TCCCCHHHHHHHHHHHHHHHHHHHHHHHCCT--------TSHHH T ss_pred HHHHHHHHhC--------------------------CCCCCCcchhHHHHHHHHHHHHHHHHHhcCC--------CCHHH Confidence 2221211110 0113356788999999999999887542110 01124 Q NP_000836.2 439 GKELLGYIRAV-NFNGSAGTPVTFNENG---DAPGRYDIFQYQ 477 (908) Q Consensus 439 ~~~l~~~l~~~-~f~G~~G~~v~Fd~~G---~~~~~~~i~~~~ 477 (908) ++.+.++|++. .|.|.+| .+.|+..+ .+...+.+.+++ T Consensus 337 ~~~l~~~l~~~~~~~g~~g-~~~~~~~~~~~~~~~~~~v~~~~ 378 (386) T 3SG0_A 337 RAAIRDQIEKSKDLALNNG-LSNMTPDNHNGYDERSAFLIEIR 378 (386) T ss_dssp HHHHHHHHTTCCSEEETTE-EECCCSSCSSCCCGGGCEEEEEE T ss_pred HHHHHHHHHhCcCccCCCC-ccccCCCCCCCccccceEEEEEe Confidence 56677888876 7888877 89997542 222355666665 No 128 >5ERE_A Extracellular ligand-binding receptor; Solute Binding Protein, Tandem PAS; HET: MSE; 2.0A {Desulfohalobium retbaense DSM 5692} Probab=99.27 E-value=4.6e-16 Score=176.57 Aligned_cols=327 Identities=15% Similarity=0.220 Sum_probs=209.8 Template_Neff=12.000 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) .++||+++|.++... ..+.....|++.|++++| .++++.+.|+++++..+. +.+++++ T Consensus 1 ~i~ig~~~p~~g~~~----------~~~~~~~~g~~~a~~~~g--------~~v~~~~~d~~~~~~~~~----~~~~~l~ 58 (568) T 5ERE_A 1 KPVVGVILPFSSAFE----------DIAVEQQRAVELALAESG--------SAFEIVFKDGGADVDTAV----QAFQDLV 58 (568) T ss_dssp CCEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHT--------CSSEEEEEECCSSHHHHH----HHHHHHH T ss_pred CCEEEEEeCCCCCcH----------HHHHHHHHHHHHHHHHcC--------CcEEEEEEcCCCCHHHHH----HHHHHHH Confidence 378999999987531 356778899999999874 457778888877654332 3333333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) .+ +++++++++ .++..+..++..+...++|+|.+.+..+.+.+ .++++++.++....+. T Consensus 59 ~~-----------------~~~~~~i~~-~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~---~~~~~~~~~~~~~~~~ 117 (568) T 5ERE_A 59 RS-----------------QENLAAVVS-CSSWASSAIHPLAAEKDIFHVAIGSAALKRTE---PGHTIRLTVGVQQEQE 117 (568) T ss_dssp HH-----------------CTTEEEEEE-ESHHHHHHHHHHHHHTTCEEEEESCTTCCCCS---TTCCEECSCCHHHHHH T ss_pred hc-----------------CCCcEEEEe-CCcHHHHhHHHHHHhCCCEEEEecCCCccccC---CCCeEEccCChHHHHH Confidence 21 025666665 56666667778888999999998776554432 3778999998888888 Q NP_000836.2 205 AMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANE 284 (908) Q Consensus 205 ~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~~~ 284 (908) ++++++. +|+++++++.++.++....+.+++.++.. +.....+. .+..++...+++++. .++|+|++.+ . T Consensus 118 ~~~~~~~--~~~~v~i~~~~~~~~~~~~~~~~~~~~~~----~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~v~~~~-~ 187 (568) T 5ERE_A 118 QLAAYLT--DFERIAVLAMDNNLGSSWIRMLEDRFPKQ----VVAAQEYN--PQQMDIAAQLATIKA-RDSEALVLIS-A 187 (568) T ss_dssp HHHHHHT--TCSSEEEEEESSHHHHHHHHHHHHHCTTT----EEEEEEEC--TTTCCCHHHHHHHHT-TTCSEEEEEC-S T ss_pred HHHHHHc--CCCEEEEEEecChhHHHHHHHHHHHcCCc----eeEEeeeC--ccCCCHHHHHHHHHh-CCCCEEEEEc-h Confidence 8888886 89999999977777777777776665431 11112222 123356666777763 5788887776 4 Q NP_000836.2 285 DDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWE 364 (908) Q Consensus 285 ~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 364 (908) ..+..+++++++.|+. +.|++.+.+...... .......+.+...+ . .+....|.+.++ T Consensus 188 ~~~~~~l~~~~~~g~~--~~~~~~~~~~~~~~~--~~~~~~~g~~~~~~-----------------~-~~~~~~~~~~~~ 245 (568) T 5ERE_A 188 GEAATIAKQARQAGIK--AQLVGTRPIQRAEVL--AASAFTNGLVYTYP-----------------S-YNQDHPFMSAFT 245 (568) T ss_dssp TTHHHHHHHHHHTTCC--CEEEECGGGCCHHHH--HTHHHHTTCEEEEE-----------------C-CCTTSHHHHHHH T ss_pred HHHHHHHHHHHHCCCC--CEEEeCChhcCHHHH--HhhhhcCeeEEEcC-----------------C-CcCCcHHHHHHH Confidence 5677888888888773 456665433221110 00111122111100 0 001111222222 Q NP_000836.2 365 ENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLG 444 (908) Q Consensus 365 ~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~l~~ 444 (908) +.++ ..++.++..+|||++++++|+++... +++.+.+ T Consensus 246 ~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~----------------~~~~~~~ 282 (568) T 5ERE_A 246 DRYG---------------------------LEPGFFGVEAYDLCTTLSRALEQGRQ----------------TPKALFE 282 (568) T ss_dssp HHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHTTCC----------------SHHHHHH T ss_pred HHHC---------------------------CCCChHHHHHHHHHHHHHHHHHhcCC----------------CHHHHHH Confidence 2221 11235678899999999999987531 3446777 Q NP_000836.2 445 YIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 445 ~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) +|++..|.|.+| ++.|+++|++...+.+.+++ ++.++.++.|... T Consensus 283 ~l~~~~~~g~~g-~~~~~~~g~~~~~~~i~~~~----~~~~~~~~~~~~~ 327 (568) T 5ERE_A 283 WYAGNTFTGALG-KVTFANDGDASYPYIFKKVT----ESGFRVAEFQFPM 327 (568) T ss_dssp HHTTCEEEETTE-EEEECTTSBEECCEEEEEEE----TTEEEECTTHHHH T ss_pred HHhcCCcccccE-EEEECCCCCccccEEEEEEE----CCeEEEEEEEcch Confidence 888888999988 89999888887778888887 3578889988764 No 129 >3CKM_A Uncharacterized protein HI1655; YraM, periplasmic-binding protein, lipoprotein, unliganded; 1.35A {Haemophilus influenzae} SCOP: c.93.1.1 Probab=99.17 E-value=3.7e-15 Score=155.57 Aligned_cols=322 Identities=12% Similarity=0.097 Sum_probs=193.4 Template_Neff=11.900 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ++++||+++|.++... ..+.....|++.|++ |+++++.+.|+.++ . ..+.++++ T Consensus 1 ~~i~ig~~~p~~~~~~----------~~~~~~~~g~~~a~~----------g~~i~~~~~d~~~~--~----~~~~~~~l 54 (327) T 3CKM_A 1 MVSQIGLLLPLSGDGQ----------ILGTTIQSGFNDAKG----------NSTIPVQVFDTSMN--S----VQDIIAQA 54 (327) T ss_pred CCeEEEEEecCCCCCh----------hHhHHHHHHHHHHHc----------CeeEEEEEEcCCcH--H----HHHHHHHH Confidence 3689999999876421 245677788888875 34577777776553 1 22333333 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANI-LRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~-~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) .. ++++++||+.++.....+... +...++|+|.+.+..+. ...++.+++.+++... T Consensus 55 ~~-------------------~~v~~iig~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~----~~~~~~~~~~~~~~~~ 111 (327) T 3CKM_A 55 KQ-------------------AGIKTLVGPLLKQNLDVILADPAQIQGMDVLALNATPNS----RAIPQLCYYGLSPEDE 111 (327) T ss_pred HH-------------------cCCCEEEcCCCcHHHHhHHHHHHHHhCCCEEeCCCCCcc----cCCCCEEEecCCHHHH Confidence 32 478899998777666666665 78889999988765432 1246678888888888 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) ++.+++++.+.+|+++++++.++.++....+.+++.+++. ++++.....+. . ..++...++++. .++|+|++.. T Consensus 112 ~~~~~~~l~~~~~~~v~vv~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~-~~~~~~~~~~~~--~~~~~v~~~~ 185 (327) T 3CKM_A 112 AESAANKMWNDGVRNPLVAMPQNDLGQRVGNAFNVRWQQL-AGTDANIRYYN--L-PADVTYFVQENN--SNTTALYAVA 185 (327) T ss_pred HHHHHHHHHHcCCCEEEEEEcCCHHHHHHHHHHHHHHHHc-CCeEeEEeecC--C-CCCcHHHHHHHh--cCCCEEEEeC Confidence 8888998877899999999977778888888888888775 35554332222 1 124445555553 4789888777 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAP-VYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAE 361 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~-~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 361 (908) ....+..+++++++.+. +..+++.+.|...... .........+.+.... .+.. . ...+...+ T Consensus 186 ~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~---------~~~~----~--~~~~~~~~ 248 (327) T 3CKM_A 186 SPTELAEMKGYLTNIVP--NLAIYASSRASASATNTNTDFIAQMNGVQFSDI---------PFFK----D--TNSPQYQK 248 (327) T ss_pred CHHHHHHHHHHHHHcCC--CCCEEeccCcCChhhhcHHhhhhhhccEEEEec---------CCCC----C--CCCHHHHH Confidence 65556777777776544 3456655433321110 0000111222221110 0000 0 00011111 Q NP_000836.2 362 FWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKE 441 (908) Q Consensus 362 ~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~ 441 (908) +.+.+... ..++.++..+||+++++++. +. T Consensus 249 -f~~~~~~~-------------------------~~~~~~~~~~yda~~~~~~~-~~----------------------- 278 (327) T 3CKM_A 249 -LAKSTGGE-------------------------YQLMRLYAMGADAWLLINQF-NE----------------------- 278 (327) T ss_pred -HHHHhCCC-------------------------CCCCHHHHHHHHHHHHHHHH-HH----------------------- Confidence 11111110 01234577899999998872 11 Q NP_000836.2 442 LLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 442 l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) .+.+++..|.|.+| ++.|+++|++...+.+.+++ ++.+..++.|.. T Consensus 279 -l~~~~~~~~~g~~g-~~~f~~~g~~~~~~~v~~~~----~g~~~~~~~~~~ 324 (327) T 3CKM_A 279 -LRQVPGYRLSGLTG-ILSADTNCNVERDMTWYQYQ----DGAIVPVVDHHH 324 (327) T ss_pred -HHHhcCCcccccce-eEEeCCCCCccCCEEEEEEE----CCEEEECCCccc Confidence 12233456888888 89999888776677777776 356777777654 No 130 >5VBG_A Penicillin-binding protein activator LpoA; Gram-negative bacteria, Outer membrane lipoprotein; HET: MSE; 2.8A {Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)} Probab=98.94 E-value=1.6e-13 Score=154.27 Aligned_cols=215 Identities=12% Similarity=0.095 Sum_probs=144.9 Template_Neff=11.300 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.++... ..+.....|++.|++ |.++++.+.|+.++. .... T Consensus 219 ~~~~~~i~Ig~~~p~sg~~~----------~~~~~~~~g~~~a~~----------g~~i~~~~~d~~~~~------~~~~ 272 (543) T 5VBG_A 219 FQQTNVSQIGLLLPLSGDGQ----------ILGTTIQSGFNDAKG----------NSTIPVQVFDTSMNS------VQDI 272 (543) T ss_dssp CCCCCCCCEEEEECCSSTTH----------HHHHHHHHHHHHHHT----------TCCCCEEEEETTTSC------HHHH T ss_pred hccCCCcEEEEEecCCCCch----------HHHHHHHHHHHHHcc----------CCCCCEEEEeCCCCC------HHHH Confidence 45678899999999987531 345677788888873 345777777876542 1222 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVAN-ILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~-~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) ++++.. +++++|||+.++.....++. ++...+||+|++.+..+. ..+++.+++.++ T Consensus 273 ~~~l~~-------------------~~v~~iig~~~s~~~~~~~~~~~~~~~ip~i~~~~~~~~----~~~~~~~~~~~~ 329 (543) T 5VBG_A 273 IAQAKQ-------------------AGIKTLVGPLLKQNLDVILADPAQIQGMDVLALNATPNS----RAIPQLCYYGLS 329 (543) T ss_dssp HHHHHH-------------------TTCCEEECCCSHHHHHHHHHCGGGGTTCEEEESCCCTTC----CCCTTEEECCCC T ss_pred HHHHHH-------------------CCCCEEECCCCHHHHHHHHcCchhhcCCeEEEecCCCCc----ccCCCceEeeCC Confidence 233222 57899999877766655544 467899999988765543 124677888888 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ....+..+++++.+.+|++|++++.++.++....+.+++.+++. ++++.....+. . ..++...++++. .++|+| T Consensus 330 ~~~~~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~-~~d~~~~~~~~~--~~~d~i 403 (543) T 5VBG_A 330 PEDEAESAANKMWNDGVRNPLVAMPQNDLGQRVGNAFNVRWQQL-AGTDANIRYYN--L-PADVTYFVQENN--SNTTAL 403 (543) T ss_dssp HHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHH-HSSCCEEEEES--S-TTHHHHHHHHHC--CTTEEE T ss_pred hHHHHHHHHHHHHHcCCCCcEEEcCCCHHHHHHHHHHHHHHHHh-hCCcCeeEEeC--C-ccchhHhhhccc--CCCCEE Confidence 88888888998887899999999977778877888888877765 45554332222 1 234445555553 378888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGSDSW 311 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~ 311 (908) ++.+.+..+..+++++++.+. ++.|++.+.| T Consensus 404 ~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~ 434 (543) T 5VBG_A 404 YAVASPTELAEMKGYLTNIVP--NLAIYASSRA 434 (543) T ss_dssp EECCCHHHHHHHHHHTTTTCT--TCEEEECGGG T ss_pred EEecCHHHHHHHHHHHhhccC--CCcEEEcchh Confidence 777666667777777776443 3456655433 No 131 >5KCN_A Penicillin-binding protein activator LpoA; Outer membrane lipoprotein, PBP1A, transpeptidase.; 1.965A {Haemophilus influenzae} Probab=98.94 E-value=1.6e-13 Score=154.22 Aligned_cols=215 Identities=12% Similarity=0.095 Sum_probs=144.4 Template_Neff=11.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.++... ..+.....|++.|++ |.++++.+.|+.++. .... T Consensus 219 ~~~~~~i~Ig~~~p~sg~~~----------~~~~~~~~g~~~a~~----------g~~i~~~~~d~~~~~------~~~~ 272 (543) T 5KCN_A 219 FQQTNVSQIGLLLPLSGDGQ----------ILGTTIQSGFNDAKG----------NSTIPVQVFDTSMNS------VQDI 272 (543) T ss_pred ccCCCCeEEEEEEeCCCCCh----------HHHHHHHHHHHHHHC----------CeeEEEEEEcCCCCH------HHHH Confidence 45678899999999986531 345677888888873 345777777776542 1222 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVAN-ILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~-~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) ++++.. ++++++||+.++.....++. ++...+||+|++.+..+. ...++.+++.++ T Consensus 273 ~~~l~~-------------------~~v~~iig~~~s~~~~~~~~~~~~~~~ip~i~~~~~~~~----~~~~~~~~~~~~ 329 (543) T 5KCN_A 273 IAQAKQ-------------------AGIKTLVGPLLKQNLDVILADPAQIQGMDVLALNATPNS----RAIPQLCYYGLS 329 (543) T ss_pred HHHHHh-------------------CCCCEEECCCChHHHHHHHHHHHHHhCCCEEeCCCCCcc----cCCCCeeEecCC Confidence 233222 57899999887766655544 468899999988765542 124677888888 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ....+..+++++.+.+|+++++++.++.++....+.+++.+++. ++++.....+. . ..++...++++. .++|+| T Consensus 330 ~~~~~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~-~~~~~~~~~~~~--~~~d~i 403 (543) T 5KCN_A 330 PEDEAESAANKMWNDGVRNPLVAMPQNDLGQRVGNAFNVRWQQL-AGTDANIRYYN--L-PADVTYFVQENN--SNTTAL 403 (543) T ss_pred HHHHHHHHHHHHHHcCCCEEEEEeCCCHHHHHHHHHHHHHHHHc-CCeEeEEEeCC--C-CCCcHHHHHHhh--cCCCEE Confidence 88888888988888899999999977778887888888877765 45554332232 1 224444555553 378888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGSDSW 311 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~ 311 (908) ++.+.+.....+++++++.+. ++.|++.+.| T Consensus 404 ~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~ 434 (543) T 5KCN_A 404 YAVASPTELAEMKGYLTNIVP--NLAIYASSRA 434 (543) T ss_pred EEcCCHHHHHHHHHHHHHhCC--CCCEEecccc Confidence 777666566777777775443 3455655433 No 132 >4PYR_A Putative branched-chain amino acid ABC; Structural Genomics, PSI-Biology, Midwest Center; HET: GSH; 1.45A {Chromobacterium violaceum} Probab=98.94 E-value=1.7e-13 Score=141.16 Aligned_cols=204 Identities=12% Similarity=0.096 Sum_probs=132.6 Template_Neff=11.700 Q NP_000836.2 45 DIILGGLFPVH-AKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 45 ~i~Ig~l~p~~-~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) +++||++.|.+ +... ..+....+|+++|+++ | .++++.+.|+++ .. ..+.++++ T Consensus 1 ~i~ig~~~~~s~g~~~----------~~~~~~~~g~~~a~~~-n--------~~i~l~~~d~~~--~~----~~~~~~~l 55 (305) T 4PYR_A 1 KVRIGVILPAESSALG----------EAAAVVRSGVEAAAQV-D--------QSAELYSVDATG--DN----VVERYRAA 55 (305) T ss_dssp CEEEEEEECCTTSTTH----------HHHHHHHHHHHHHHHH-H--------CCEEEEEEECCG--GG----HHHHHHHH T ss_pred CeeEEEEecCCCccch----------HHHHHHHHHHHHHHhc-C--------CCCeEEEEeCCC--cc----HHHHHHHH Confidence 47899999988 6431 3567788999999998 6 246677777654 21 22233333 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) +. ++++++||+.++.....++. ..++|+|.+.+..+. . ...++.+++.++...++ T Consensus 56 ~~-------------------~~v~~iig~~~s~~~~~~~~---~~~ip~i~~~~~~~~-~--~~~~~~~~~~~~~~~~~ 110 (305) T 4PYR_A 56 VA-------------------DGVNVVIGPLSRDSIVKLAP---SVTVPTLALNSVGRE-A--AANPKLYSLSLIVEGEA 110 (305) T ss_dssp HH-------------------TTCCEEECCCSHHHHHHHGG---GCCSCEEESSCCCTT-S--CCCTTEEECCCCHHHHH T ss_pred HH-------------------CCCCEEECCCCHHHHHHHhh---cCCCCEEEecCCChh-h--ccCCCeEEEecChHHHH Confidence 32 47889999877665544433 689999987765443 1 13567788888888888 Q NP_000836.2 204 QAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFAN 283 (908) Q Consensus 204 ~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~~ 283 (908) ..+++++.+.+|+++++++.+++++....+.+++.+++. ++++.....+.. .++...+. + ..++|+|++... T Consensus 111 ~~~~~~~~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~----~d~~~~~~--~-~~~~d~v~~~~~ 182 (305) T 4PYR_A 111 RQLARLMRDDSRAAPLLVVGGDALSQRLGKAFADEWRAA-AGKPVRQMAFDA----NDMAPLLQ--A-AGQADAVALALD 182 (305) T ss_dssp HHHHHHHHHTTCSSEEEEECSSHHHHHHHHHHHHHHHHH-HSSCCEEEECCT----TCCHHHHH--H-HHTCSEEEEESC T ss_pred HHHHHHHHHCCCCceEEEEcCCHHHHHHHHHHHHHHHHC-CCcccEEEEeCh----hhhHHHHH--h-hcCCCEEEEeCC Confidence 899999887899999999977778888888888877765 455543322221 13333332 2 247898877765 Q NP_000836.2 284 EDDIRRILEAAKKLNQSGHFLWIGSDSW 311 (908) Q Consensus 284 ~~~~~~~l~~~~~~g~~~~~~~i~~~~~ 311 (908) .... .++.++.+. +..|++.+.| T Consensus 183 ~~~~-~~l~~~~~~----~~~~~~~~~~ 205 (305) T 4PYR_A 183 VAQA-ARLKSALTP----DVPVYGTSQL 205 (305) T ss_dssp HHHH-HHHHHHSCT----TSCEEECGGG T ss_pred HHHH-HHHHHHcCC----CCCEEeeccc Confidence 4444 555554431 2456665433 No 133 >4YLE_A Simple sugar transport system substrate-binding; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: MSE; 1.7A {Burkholderia multivorans} Probab=97.77 E-value=1.5e-08 Score=103.45 Aligned_cols=224 Identities=12% Similarity=0.071 Sum_probs=130.6 Template_Neff=12.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+.++||++.|..+. ..+.....+++.++++.|. ++++.+...|+..++ +...+. T Consensus 27 ~~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~a~~~~~~------~~~~~~~~~d~~~~~----~~~~~~ 84 (316) T 4YLE_A 27 AQAAGKPKVALVMKSLAN------------EFFLTMENGAKEYQKHNAS------QFDLITNGIKDETDT----ANQIRI 84 (316) T ss_dssp ---CCCCEEEEEEEETTS------------HHHHHHHHHHHHHHHHTTT------TCEEEEEEESSTTCH----HHHHHH T ss_pred hhhcCCCEEEEEecCCCC------------hHHHHHHHHHHHHHHhcCC------ccEEEEcccCCCCCH----HHHHHH Confidence 355678999999997542 2556778888888888653 233443333433332 222333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) ++++.. ++++++|+...+.... .....+...++|+|..+...+........++++++.++ T Consensus 85 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~~~~~~~~~~v~~~ 145 (316) T 4YLE_A 85 VEQMIV-------------------SKVDAIVLAPADSKALVPVVKKAVDAGIIVVNIDNRLDPDVLKSKNLNVPFVGPD 145 (316) T ss_dssp HHHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCEEEEESSCCCHHHHHTTTCCCCEEEEC T ss_pred HHHHHh-------------------cCCCEEEEcCCCccchHHHHHHHHHCCCEEEEEeCCCChHHHhhcCCCCcEeccC Confidence 444332 4788888754443322 44456677899999887654321111113567788888 Q NP_000836.2 199 DSYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TP 273 (908) Q Consensus 199 ~~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~ 273 (908) +...++.+++++.+. +.+++++++. ++.++..+.+++++.+++. ++.+....... .+..+....++++++ .. T Consensus 146 ~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 222 (316) T 4YLE_A 146 NRKGARKVGDYLAKKLKAGDQVGIVEGVSTTTNAQQRTAGFQDAMKAG-GMKVVSVQSGE--WEIDKGNAVASAMLNEYP 222 (316) T ss_dssp HHHHHHHHHHHHHHHSCTTCEEEEEESCTTSHHHHHHHHHHHHHHHHH-TCEEEEEEECT--TCHHHHHHHHHHHHHHCT T ss_pred hHHHHHHHHHHHHHHccCCCeEEEEEcCCCChhHHHHHHHHHHHHHhC-CCeEEEEeecC--CCHHHHHHHHHHHHHHCC Confidence 888888888887654 4678999885 4456677788888888775 35443221111 112233444555542 13 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++++|++.. +..+..+++++++.|+..++.+++. T Consensus 223 ~~~~i~~~~-~~~~~~~~~~l~~~g~~~~~~i~~~ 256 (316) T 4YLE_A 223 NLKALLCGN-DNMAIGAVSAVRAAGKQGKVYVVGY 256 (316) T ss_dssp TCCEEEESS-HHHHHHHHHHHHHTTCTTTSEEECS T ss_pred CeeEEEECC-hHHHHHHHHHHHHcCCCCCeEEEEe Confidence 566776654 4456677888888776333444444 No 134 >4RK1_B Ribose transcriptional regulator; sugar binding, transcription regulation, Enzyme; HET: CL, MSE, RIB; 1.9A {Enterococcus faecium DO} Probab=97.68 E-value=2.9e-08 Score=99.18 Aligned_cols=204 Identities=13% Similarity=0.094 Sum_probs=120.4 Template_Neff=12.200 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++.....+++.++++.+ +++.+.|+..++. ...+.++ T Consensus 4 ~~~~~~I~~~~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~ 57 (280) T 4RK1_B 4 TKETKTIGVLVPDITN------------PFFSTLMRGIEDILYKQN----------FVTILCNADSDHQ----KEIEYLA 57 (280) T ss_dssp ----CEEEEEESCTTS------------HHHHHHHHHHHHHHGGGT----------CEEEEEECCC---------CCHHH T ss_pred ccCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHCC----------CEEEEEeCCCCHH----HHHHHHH Confidence 4567899999987542 245667788888877642 3344455443322 2233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++.. ++++++|+...+.........+...++|+|..+...+ .++.+++.+++.. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~~~~~ 111 (280) T 4RK1_B 58 ELTR-------------------RGVDGFIIATSAVSTDAINENLKKQGRPFIVLDQKKS-------EGFSDAVRTDDFR 111 (280) T ss_dssp HHHH-------------------TTCCEEEECCTTSCHHHCCCCCCTTTCCEEEETTSCC-------CTTCEEEEECHHH T ss_pred HHHH-------------------cCCCEEEEeCCCCChHHHHHHHHHcCCCEEEECCCCC-------CCCCceEEECcHH Confidence 3332 4788888755443333445566778999988765432 1356677777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) .++.+++++.+.+++++++++. +..++..+.++|++.+++. ++.+..........+..+....++++++ .++|+|+ T Consensus 112 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~d~i~ 189 (280) T 4RK1_B 112 GGYLAGMHLLSLGHQTIALVYPENPPENVHARIEGFKSALDVY-QIPHDQLILLPTQFSKQGGYQITAELLD-SAATGVF 189 (280) T ss_dssp HHHHHHHHHHHTTCCSEEEEEESSCCHHHHHHHHHHHHHHHHT-TCCGGGEEEEEECSSHHHHHHTHHHHHH-SCCCEEE T ss_pred HHHHHHHHHHHCCCCEEEEEcCCCCChHHHHHHHHHHHHHHHc-CCCccceEEeCCCcccccHHHHHHHHhh-CCCCEEE Confidence 7888888887678889999985 3345666778888887764 3333211111100112234455566653 4788887 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~ 300 (908) +.. +..+..+++++++.|+. T Consensus 190 ~~~-~~~~~~~~~~l~~~g~~ 209 (280) T 4RK1_B 190 ALN-DELAFGLYRGLEEAGKS 209 (280) T ss_dssp ESS-HHHHHHHHHHHHHTTCC T ss_pred ECC-hHHHHHHHHHHHHcCCC Confidence 765 33467788888887764 No 135 >4RK1_D Ribose transcriptional regulator; sugar binding, transcription regulation, Enzyme; HET: RIB, CL; 1.9A {Enterococcus faecium DO} Probab=97.68 E-value=2.9e-08 Score=99.18 Aligned_cols=204 Identities=13% Similarity=0.094 Sum_probs=120.7 Template_Neff=12.200 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++.....+++.++++.+ +++.+.|+..++. ...+.++ T Consensus 4 ~~~~~~I~~~~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~ 57 (280) T 4RK1_D 4 TKETKTIGVLVPDITN------------PFFSTLMRGIEDILYKQN----------FVTILCNADSDHQ----KEIEYLA 57 (280) T ss_dssp ----CEEEEEESCTTS------------HHHHHHHHHHHHHHHTTT----------CEEEEEECCC--------CCCHHH T ss_pred ccCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHCC----------CEEEEEeCCCCHH----HHHHHHH Confidence 4567899999987542 245667788888877642 3344455443322 2233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++.. ++++++|+...+.........+...++|+|..+...+ .++.+++.+++.. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~~~~~ 111 (280) T 4RK1_D 58 ELTR-------------------RGVDGFIIATSAVSTDAINENLKKQGRPFIVLDQKKS-------EGFSDAVRTDDFR 111 (280) T ss_dssp HHHH-------------------TTCCEEEECCTTSCHHHCCCCCCTTTCCEEEETTSCC-------CTTCEEEEECHHH T ss_pred HHHH-------------------cCCCEEEEeCCCCChHHHHHHHHHcCCCEEEECCCCC-------CCCCceEEECcHH Confidence 3332 4788888755443333445566778999988765432 1356677777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) .++.+++++.+.+++++++++. +..++..+.++|++.+++. ++.+..........+..+....++++++ .++|+|+ T Consensus 112 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~d~i~ 189 (280) T 4RK1_D 112 GGYLAGMHLLSLGHQTIALVYPENPPENVHARIEGFKSALDVY-QIPHDQLILLPTQFSKQGGYQITAELLD-SAATGVF 189 (280) T ss_dssp HHHHHHHHHHHTTCCSEEEEEESSCCHHHHHHHHHHHHHHHHT-TCCGGGEEEEEECSSHHHHHHTHHHHHT-SCCSEEE T ss_pred HHHHHHHHHHHCCCCEEEEEcCCCCChHHHHHHHHHHHHHHHc-CCCccceEEeCCCcccccHHHHHHHHhh-CCCCEEE Confidence 7888888887678889999985 3345666778888887764 3333211111100112234455566653 4788887 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~ 300 (908) +.. +..+..+++++++.|+. T Consensus 190 ~~~-~~~~~~~~~~l~~~g~~ 209 (280) T 4RK1_D 190 ALN-DELAFGLYRGLEEAGKS 209 (280) T ss_dssp ESS-HHHHHHHHHHHHHTTCC T ss_pred ECC-hHHHHHHHHHHHHcCCC Confidence 765 33467788888887764 No 136 >3BRQ_A HTH-type transcriptional regulator ascG; transcriptional repressor structure Escherichia coli; HET: MSE, SO4, FRU; 2.0A {Escherichia coli} Probab=97.64 E-value=3.8e-08 Score=99.33 Aligned_cols=208 Identities=10% Similarity=0.021 Sum_probs=121.6 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||++.|..+.. ..++.....+++.++++.+ +++.+.|+..++. ...+.+ T Consensus 15 ~~~~~~~I~~i~~~~~~~----------~~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~ 70 (296) T 3BRQ_A 15 SAKSTQTLGLVVTNTLYH----------GIYFSELLFHAARMAEEKG----------RQLLLADGKHSAE----EERQAI 70 (296) T ss_dssp ----CCEEEEEECGGGCC------------CHHHHHHHHHHHHHHTT----------CEEEEECCTTSHH----HHHHHH T ss_pred ccCCCCEEEEEecCcccC----------CccHHHHHHHHHHHHHHcC----------CeEEEEeCCCCHH----HHHHHH Confidence 345689999999976421 1245567778877777642 3444555544422 233344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .+++++|+...+.....+...++..++|+|..+...+. +.++++..++. T Consensus 71 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-------~~~~~v~~~~~ 124 (296) T 3BRQ_A 71 QYLLD-------------------LRCDAIMIYPRFLSVDEIDDIIDAHSQPIMVLNRRLRK-------NSSHSVWCDHK 124 (296) T ss_dssp HHHHH-------------------TTCSEEEEECSSSCHHHHHHHHHTCSSCEEEESCCCSS-------SGGGEECCCHH T ss_pred HHHHh-------------------cCCCEEEEeCCCCChhhHHHHHHHcCCCEEEeCCCCCC-------CCCcEEEeCcH Confidence 44332 47888887655443334445566789999987764331 34566667777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ..++.+++++.+.++++++++..+.. ++..+.++|++.+++. ++.+.....+..+.+..+....++++++. .++|+ T Consensus 125 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 203 (296) T 3BRQ_A 125 QTSFNAVAELINAGHQEIAFLTGSMDSPTSIERLAGYKDALAQH-GIALNEKLIANGKWTPASGAEGVEMLLERGAKFSA 203 (296) T ss_dssp HHHHHHHHHHHHTTCCSEEEECCCTTCHHHHHHHHHHHHHHHTT-TCCCCGGGEECCCSSHHHHHHHHHHHHTC--CCSE T ss_pred HHHHHHHHHHHHCCCCeEEEEeCCCCChhHHHHHHHHHHHHHHC-CCCCCccceecCCCChhhHHHHHHHHHHcCCCCCE Confidence 77777788876668899999985433 5666778888888775 34433221111101122344455555431 23777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 204 v~~~~-~~~~~~~~~~~~~~g~~ 225 (296) T 3BRQ_A 204 LVASN-DDMAIGAMKALHERGVA 225 (296) T ss_dssp EEESS-HHHHHHHHHHHHHHTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 77664 44566778888887764 No 137 >3BRQ_B HTH-type transcriptional regulator ascG; transcriptional repressor structure Escherichia coli; HET: SO4, FRU; 2.0A {Escherichia coli} Probab=97.64 E-value=3.8e-08 Score=99.33 Aligned_cols=208 Identities=10% Similarity=0.021 Sum_probs=122.3 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||++.|..+.. ..++.....+++.++++.+ +++.+.|+..++. ...+.+ T Consensus 15 ~~~~~~~I~~i~~~~~~~----------~~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~ 70 (296) T 3BRQ_B 15 SAKSTQTLGLVVTNTLYH----------GIYFSELLFHAARMAEEKG----------RQLLLADGKHSAE----EERQAI 70 (296) T ss_dssp ----CCEEEEEEECCSCC----------SSCHHHHHHHHHHHHHHTT----------CEEEEEEEETSHH----HHHHHH T ss_pred ccCCCCEEEEEecCcccC----------CccHHHHHHHHHHHHHHcC----------CeEEEEeCCCCHH----HHHHHH Confidence 345689999999976421 1245567778877777642 3444555544422 233344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .+++++|+...+.....+...++..++|+|..+...+. +.++++..++. T Consensus 71 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-------~~~~~v~~~~~ 124 (296) T 3BRQ_B 71 QYLLD-------------------LRCDAIMIYPRFLSVDEIDDIIDAHSQPIMVLNRRLRK-------NSSHSVWCDHK 124 (296) T ss_dssp HHHHH-------------------TTCSEEEEECSSSCHHHHHHHHHTCSSCEEEESSCCSS-------CGGGEECBCHH T ss_pred HHHHh-------------------cCCCEEEEeCCCCChhhHHHHHHHcCCCEEEeCCCCCC-------CCCcEEEeCcH Confidence 44332 47888887655443334445566789999987764331 34566667777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ..++.+++++.+.++++++++..+.. ++..+.++|++.+++. ++.+.....+..+.+..+....++++++. .++|+ T Consensus 125 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 203 (296) T 3BRQ_B 125 QTSFNAVAELINAGHQEIAFLTGSMDSPTSIERLAGYKDALAQH-GIALNEKLIANGKWTPASGAEGVEMLLERGAKFSA 203 (296) T ss_dssp HHHHHHHHHHHHTTCCSEEEECCCTTCHHHHHHHHHHHHHHHHT-TCCCCGGGEECCCSSHHHHHHHHHHHHHHCCCCSE T ss_pred HHHHHHHHHHHHCCCCeEEEEeCCCCChhHHHHHHHHHHHHHHC-CCCCCccceecCCCChhhHHHHHHHHHHcCCCCCE Confidence 77777788876668899999985433 5666778888888775 34433221111101122344455555431 23777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 204 v~~~~-~~~~~~~~~~~~~~g~~ 225 (296) T 3BRQ_B 204 LVASN-DDMAIGAMKALHERGVA 225 (296) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 77664 44566778888887764 No 138 >5DTE_B Monosaccharide-transporting ATPase (E.C.3.6.3.17); Solute Binding Protein, ENZYME FUNCTION; HET: ALL; 2.7A {Actinobacillus succinogenes (strain ATCC 55618 / 130Z)} Probab=97.59 E-value=5.2e-08 Score=99.26 Aligned_cols=222 Identities=16% Similarity=0.113 Sum_probs=126.5 Template_Neff=11.700 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||++.|..+. .++.....+++.++++. |+++.+...|+..++ +...+.+ T Consensus 22 ~~~~~~~Igvv~~~~~~------------~~~~~~~~g~~~a~~~~--------g~~v~~~~~~~~~~~----~~~~~~~ 77 (311) T 5DTE_B 22 SMADKPQIALLMKTLSN------------EYFISMRQGAEETAKQK--------DIDLIVQVAEKEDST----EQLVGLV 77 (311) T ss_dssp ---CCCEEEEEESCSSS------------HHHHHHHHHHHHHHHHT--------TCEECCEECSSTTCH----HHHHHHH T ss_pred ccCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHc--------CCEEEEEccCCCCcH----HHHHHHH Confidence 34468999999997542 25567788888888775 345655555543332 1222333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++++. ++++++|+...+... ......+.+.++|+|..+...+........++.+.+.+++ T Consensus 78 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~~~~~~~~~~v~~d~ 138 (311) T 5DTE_B 78 ENMIA-------------------KKVDAIIVTPNDSIAFIPAFQKAEKAGIPIIDLDVRLDAKAAEAAGLKFNYVGVDN 138 (311) T ss_dssp HHHHH-------------------TTCSEEEECCSCTTTTHHHHHHHHHTTCCEEEESSCCCHHHHHHTTCCCEEEECCH T ss_pred HHHHh-------------------CCCCEEEECCCCccchHHHHHHHHHCCCCEEEEcCCCCHHHHHHhcCceEEEEeCh Confidence 43332 467877764433322 2444566778999998876543211100124567777888 Q NP_000836.2 200 SYQAQAMVDIVTAL-GW-NYVSTLASE--GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPN 274 (908) Q Consensus 200 ~~~~~~~~~~l~~~-~~-~~v~ii~~~--~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~ 274 (908) ...++.+++++.+. +. ++++++... ..++..+.++|++.+++.+++++....... .+..+....++++++ ..+ T Consensus 139 ~~~~~~~~~~l~~~~g~~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~ 216 (311) T 5DTE_B 139 FNGGYLEAKNLAEAIGKKGNVAILEGIPGVDNGEQRKGGALKAFAEYPDIKIVASQSAN--WETEQALNVTTNILTANPN 216 (311) T ss_dssp HHHHHHHHHHHHHHTTSEEEEEEEECCSSCHHHHHHHHHHHHHHTTCTEEEEEEEEECT--TCHHHHHHHHHHHTTTSTT T ss_pred HHHHHHHHHHHHHHhCCCeEEEEEECCCCChhHHHHHHHHHHHHHhCCCeEEEEeccCC--CCHHHHHHHHHHHHHHCCC Confidence 77888888887654 76 889999743 235667788888887764223332211111 112234444555542 135 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|+|++.. +..+..+++++++.|+..++.+++. T Consensus 217 ~d~i~~~~-~~~a~~~~~~l~~~g~~~~i~vi~~ 249 (311) T 5DTE_B 217 INGIFAAN-DNMAIGAVTAVENAGLAGKVLVSGY 249 (311) T ss_dssp CCEEEESS-HHHHHHHHHHHHHTTCBTTBEEECC T ss_pred cCEEEECC-hhhHHHHHHHHHHCCCCCCeEEEEe Confidence 66676553 4456677888887776323344443 No 139 >3KSM_B ABC-type sugar transport system, periplasmic; ABC-type sugar transport system, periplasmic; HET: MSE, BDR; 1.9A {Hahella chejuensis} Probab=97.58 E-value=5.5e-08 Score=96.87 Aligned_cols=212 Identities=15% Similarity=0.056 Sum_probs=121.5 Template_Neff=12.200 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIE 125 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~~ 125 (908) ++||++.|..+. .++..+..+++.++++. |+++.+...|+..++. ...+.+++++. T Consensus 1 i~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~~~~~~~~~~~~~~----~~~~~~~~~~~ 56 (276) T 3KSM_B 1 PKLLLVLKGDSN------------AYWRQVYLGAQKAADEA--------GVTLLHRSTKDDGDIA----GQIQILSYHLS 56 (276) T ss_dssp -CEEEECSCSSS------------THHHHHHHHHHHHHHHH--------TCCEEECCCSSTTCHH----HHHHHHHHHHH T ss_pred CeEEEEcCCCCC------------HHHHHHHHHHHHHHHHh--------CCEEEEecCCCCCCHH----HHHHHHHHHHH Confidence 478999887542 25567778888888775 3456555545433322 22333333332 Q NP_000836.2 126 KDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 126 ~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) .+++|++|+...+.... .....+...++|+|..+...+. .++++++.+++...++ T Consensus 57 ------------------~~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~d~~~~~~ 112 (276) T 3KSM_B 57 ------------------QAPPDALILAPNSAEDLTPSVAQYRARNIPVLVVDSDLAG------DAHQGLVATDNYAAGQ 112 (276) T ss_dssp ------------------CCC-CEEEECCSCTTTTHHHHHHHHHTTCCEEEESSCCSS------SSSSEEEECCHHHHHH T ss_pred ------------------hCCCCEEEEcCCCHHhcHHHHHHHHHCCCCEEEEcCCCCC------CccceEEEcCHHHHHH Confidence 14788887654443322 3345567789999987654321 2456777777777777 Q NP_000836.2 205 AMVDIVTAL----GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 205 ~~~~~l~~~----~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) .+++++.+. +.++++++.. ++.++..+.++|++.+++.+ ........+.. .+..+....+++++.. .++++ T Consensus 113 ~~~~~l~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~ 190 (276) T 3KSM_B 113 LAARALLATLDLSKERNIALLRLRAGNASTDQREQGFLDVLRKHD-KIRIIAAPYAG-DDRGAARSEMLRLLKETPTIDG 190 (276) T ss_dssp HHHHHHHHHSCTTSCEEEEECBCCTTCHHHHHHHHHHHHHHTTCT-TEEEEECCBCC-SCHHHHHHHHHHHHHHCSCCCE T ss_pred HHHHHHHHHcCcCCCceEEEEECCCCChhHHHHHHHHHHHHhhcC-CeEEEECCcCC-CCHHHHHHHHHHHHHHCCCCCE Confidence 888877554 7889999985 34556667788888877643 22111111110 1112333445555421 24677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) |++.. +..+..+++++++.|+..++.+++. T Consensus 191 i~~~~-~~~~~~~~~~l~~~g~~~~~~i~~~ 220 (276) T 3KSM_B 191 LFTPN-ESTTIGALVAIRQSGMSKQFGFIGF 220 (276) T ss_dssp EECCS-HHHHHHHHHHHHHTTCTTSSEEEEE T ss_pred EEeCC-hHHHHHHHHHHHHcCCCCceEEEee Confidence 76654 4456678888888776433444443 No 140 >3KSM_A ABC-type sugar transport system, periplasmic; ABC-type sugar transport system, periplasmic; HET: BDR; 1.9A {Hahella chejuensis} Probab=97.58 E-value=5.5e-08 Score=96.87 Aligned_cols=212 Identities=15% Similarity=0.056 Sum_probs=122.8 Template_Neff=12.200 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIE 125 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~~ 125 (908) ++||++.|..+. .++..+..+++.++++. |+++.+...|+..++. ...+.+++++. T Consensus 1 i~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~~~~~~~~~~~~~~----~~~~~~~~~~~ 56 (276) T 3KSM_A 1 PKLLLVLKGDSN------------AYWRQVYLGAQKAADEA--------GVTLLHRSTKDDGDIA----GQIQILSYHLS 56 (276) T ss_dssp CEEEEECSCSSS------------THHHHHHHHHHHHHHHH--------TCEEEECCCSSTTCHH----HHHHHHHHHHH T ss_pred CeEEEEcCCCCC------------HHHHHHHHHHHHHHHHh--------CCEEEEecCCCCCCHH----HHHHHHHHHHH Confidence 478999887542 25567778888888775 3456555545433322 22333333332 Q NP_000836.2 126 KDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 126 ~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) .+++|++|+...+.... .....+...++|+|..+...+. .++++++.+++...++ T Consensus 57 ------------------~~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~d~~~~~~ 112 (276) T 3KSM_A 57 ------------------QAPPDALILAPNSAEDLTPSVAQYRARNIPVLVVDSDLAG------DAHQGLVATDNYAAGQ 112 (276) T ss_dssp ------------------HSCCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCSS------SCSSEEEECCHHHHHH T ss_pred ------------------hCCCCEEEEcCCCHHhcHHHHHHHHHCCCCEEEEcCCCCC------CccceEEEcCHHHHHH Confidence 14788887654443322 3345567789999987654321 2456777777777777 Q NP_000836.2 205 AMVDIVTAL----GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 205 ~~~~~l~~~----~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) .+++++.+. +.++++++.. ++.++..+.++|++.+++.+ ........+.. .+..+....+++++.. .++++ T Consensus 113 ~~~~~l~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~ 190 (276) T 3KSM_A 113 LAARALLATLDLSKERNIALLRLRAGNASTDQREQGFLDVLRKHD-KIRIIAAPYAG-DDRGAARSEMLRLLKETPTIDG 190 (276) T ss_dssp HHHHHHHHHSCTTSCEEEEECBCCTTCHHHHHHHHHHHHHHTTCT-TEEEEECCBCC-SSHHHHHHHHHHHHHHCSCCCE T ss_pred HHHHHHHHHcCcCCCceEEEEECCCCChhHHHHHHHHHHHHhhcC-CeEEEECCcCC-CCHHHHHHHHHHHHHHCCCCCE Confidence 888877554 7889999985 34556667788888877643 22111111110 1112333445555421 24677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) |++.. +..+..+++++++.|+..++.+++. T Consensus 191 i~~~~-~~~~~~~~~~l~~~g~~~~~~i~~~ 220 (276) T 3KSM_A 191 LFTPN-ESTTIGALVAIRQSGMSKQFGFIGF 220 (276) T ss_dssp EECCS-HHHHHHHHHHHHHTTCTTSSEEEEE T ss_pred EEeCC-hHHHHHHHHHHHHcCCCCceEEEee Confidence 76654 4456678888888776433444443 No 141 >4RSM_A Periplasmic binding protein/LacI transcriptional regulator; SUGAR TRANSPORTER, ABC-TYPE, ENZYME FUNCTION; HET: 3VB; 1.6A {Mycobacterium smegmatis} Probab=97.58 E-value=5.6e-08 Score=99.91 Aligned_cols=213 Identities=12% Similarity=0.053 Sum_probs=123.2 Template_Neff=11.300 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...+++++||++.|.++ .++.....+++.++++.| +++.+.|...+. ....+. T Consensus 7 ~~~~~~~~Ig~i~~~~~-------------~~~~~~~~g~~~~~~~~~----------~~l~~~~~~~~~----~~~~~~ 59 (327) T 4RSM_A 7 AANSDTTRIGVTVYDMS-------------SFITAGKEGMDAYAKDNN----------IELIWNSANLDV----STQASQ 59 (327) T ss_dssp ----CCEEEEEEESCCC-------------HHHHHHHHHHHHHHHHHT----------EEEEEEECTTCH----HHHHHH T ss_pred cccCCCeEEEEEECCcc-------------HHHHHHHHHHHHHHHhCC----------CEEEEecCCCCH----HHHHHH Confidence 45677899999998753 245667778888887653 344455544332 222333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+.. .......+...++|+|..+...+. .++.+++.++ T Consensus 60 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d 114 (327) T 4RSM_A 60 VDSMIN-------------------QGVDAIIVVPVQADSLAPQVASAKAKGIPLVPVNAALDS------KDIAGNVQPD 114 (327) T ss_dssp HHHHHH-------------------TTCSEEEEECSCSSCCHHHHHHHHHTTCCEEEBSSCCSC------SCSSCCBEEC T ss_pred HHHHHH-------------------cCCCEEEEeCCCccchHHHHHHHHHCCCCEEEECCCCCc------cCCceEEcCC Confidence 443332 46787775433322 224445566789999987764331 2456777788 Q NP_000836.2 199 DSYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-- 272 (908) Q Consensus 199 ~~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-- 272 (908) +...+..+++++.+. +.++|+++.. ++.++..+.+++.+.+++.+++.+....... .+..+....+++++.. T Consensus 115 ~~~~~~~~~~~l~~~~~~~~~i~~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~ 192 (327) T 4RSM_A 115 DVAAGAQEMQMMADRLGGKGNIVILQGPLGQSGELDRSKGIEQVLAKYPDIKVLAKDTAN--WKRDEAVNKMKNWISGFG 192 (327) T ss_dssp HHHHHHHHHHHHHHHHTTCEEEEEEECSTTSHHHHHHHHHHHHHHHHCTTEEEEEEEECT--TCHHHHHHHHHHHHHHHG T ss_pred HHHHHHHHHHHHHHHhCCCcEEEEEECCCCChhHHHHHHHHHHHHHhCCCeEEEEEecCC--CCHHHHHHHHHHHHHhhc Confidence 777788888887654 6789999985 4445667778888877664223332211111 1112334445555421 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) .++|+|++.. +..+..+++++++.|.. ++.+++. T Consensus 193 ~~~d~i~~~~-~~~a~~~~~al~~~g~~-~~~iig~ 226 (327) T 4RSM_A 193 PQIDGVVAQN-DDMGLGALQALKESGRT-GVPIVGI 226 (327) T ss_dssp GGCCEEEESS-HHHHHHHHHHHHHTTCC-CCCEECS T ss_pred CCCCEEEECC-hHHHHHHHHHHHHcCCC-CCCEEEe Confidence 3577777664 33566778888877763 2344444 No 142 >6HBD_B ABC transporter periplasmic-binding protein YtfQ; periplasmic binding protein, SUGAR BINDING; HET: GZL, ZN; 2.44A {Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)} Probab=97.57 E-value=5.7e-08 Score=99.43 Aligned_cols=211 Identities=12% Similarity=0.056 Sum_probs=122.7 Template_Neff=11.600 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) ....++.++||++.|..+. .++.....+++.++++.| +++.+.|+..++. ...+ T Consensus 11 ~~~~~~~~~Igvi~~~~~~------------~~~~~~~~g~~~a~~~~~----------~~l~~~~~~~~~~----~~~~ 64 (320) T 6HBD_B 11 GSAPDGALTLGFAQVGAES------------GWRTANTESIKSAAEEAG----------VNLKFADANGEQE----KQIS 64 (320) T ss_dssp -----CCEEEEEECCCCCS------------HHHHHHHHHHHHHHHHHT----------EEEEEECCTTCHH----HHHH T ss_pred CCCCCCCcEEEEEecCCCC------------HHHHHHHHHHHHHHHHcC----------CEEEEECCCCCHH----HHHH Confidence 4566788999999987542 255667788888887653 3444555543322 2233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASS-VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~-~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. ++++++|....+. ........+...++|+|..+...+... ..++++++.+ T Consensus 65 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~---~~~~~~~v~~ 122 (320) T 6HBD_B 65 AIRSFIQ-------------------QGVDVIAFSPVVRTGWDAVLQETKNAGIPVILTDRAVDTQD---TDVYKTFIGA 122 (320) T ss_dssp HHHHHHH-------------------HTCSEEEECCSSSSSCHHHHHHHHHHTCCEEEESCCCCCSS---SSSCSEEEEC T ss_pred HHHHHHH-------------------cCCCEEEEcCCCccCHHHHHHHHHHCCCCEEEeCCCCCCCC---CcchheEecC Confidence 3443332 4677766543332 223445566678999998776543211 1355677888 Q NP_000836.2 198 PDSYQAQAMVDIVTA-----LGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL 270 (908) Q Consensus 198 ~~~~~~~~~~~~l~~-----~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~ 270 (908) ++...+..+++++.+ .+.++++++.. +..++..+.++|++.+++.+++.+....... .+..+....+++++ T Consensus 123 d~~~~~~~~~~~l~~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~ 200 (320) T 6HBD_B 123 DFIEEGRRAGQWVADQYASATGPVNIVQLEGTTGADPAIDRKTGFAEGISKNPNLKIVASQTGD--FTRSGGKQVMEAFL 200 (320) T ss_dssp CHHHHHHHHHHHHHHHSSSCSSCEEEEEEECSTTCHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TSHHHHHHHHHHHH T ss_pred ChHHHHHHHHHHHHHHHHhcCCCceEEEEEcCCCChHHHHHHHHHHHHHhhCCCeEEEEeecCC--CCHHHHHHHHHHHH Confidence 877777788877754 47789999985 3456667778888887764224443221111 11223444555554 Q NP_000836.2 271 E-TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 271 ~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) + ..++|+|++.. +..+..+++++++.|+. T Consensus 201 ~~~~~~d~i~~~~-~~~a~~~~~~l~~~g~~ 230 (320) T 6HBD_B 201 KSTPQIDVVFAQN-DDMGLGAMEAIEAAGKK 230 (320) T ss_dssp HHCSCCCEEEESS-HHHHHHHHHHHHHTTCC T ss_pred HHCCCCCEEEECC-HHHHHHHHHHHHHcCCC Confidence 2 13567776654 34556788888887764 No 143 >4JOQ_A ABC ribose transporter, periplasmic solute-binding; structural genomics, ribose, ABC transporter; 1.9A {Rhodobacter sphaeroides} Probab=97.56 E-value=6.4e-08 Score=97.68 Aligned_cols=218 Identities=11% Similarity=0.018 Sum_probs=129.3 Template_Neff=12.000 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++.....+++.+++++|+.+ ..+++.+.++ .++ ....+.++ T Consensus 4 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~~~~~-----~~~~~~~~~~-~~~----~~~~~~~~ 61 (297) T 4JOQ_A 4 QEKVGTIGIAIPSATH------------GFMGGLNFHAQDTIKRLQEVY-----PQLDFVLATA-GNA----GKMVNDIE 61 (297) T ss_dssp CCCCEEEEEEEECCSS------------HHHHHHHHHHHHHHHHHHHHC-----TTEEEEEEEE-SSH----HHHHHHHH T ss_pred cccceEEEEEeccCCC------------hhHHHHHHHHHHHHHHHHHHc-----ccccEEEEcC-CCH----HHHHHHHH Confidence 4578999999997642 256677889999999988643 1344444444 222 12223334 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. .++++++|+...+.... .....+...++|+|..+...+. ..++.+++.+++. T Consensus 62 ~l~~------------------~~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~-----~~~~~~~v~~d~~ 118 (297) T 4JOQ_A 62 DMVA------------------TRNISALVVLPFESEPLTSPVQAVKEAGIWVTVVDRGLSV-----EGIEDLYVAGDNP 118 (297) T ss_dssp HHHH------------------HHCCSEEEECCSSTTTTHHHHHHHHHTTCEEEEESSCCSS-----SSCCSEEEEECHH T ss_pred HHHH------------------hCCCCEEEEcCCCCCCCcHHHHHHHHcCCEEEEEeCCCCC-----CCceeEEEEcCch Confidence 3332 14788888765444322 3445566789999987764431 1345677778887 Q NP_000836.2 201 YQAQAMVDIVTAL--GWNYVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~--~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ..++.+++++.+. +.++++++..+ ..++..+.+++++.+++. ++++....... .+..+....++++++. .+++ T Consensus 119 ~~~~~~~~~l~~~~~~~~~i~~l~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~ 195 (297) T 4JOQ_A 119 GFGRVAGEYFAQHLESGKKIVVLRGIPTTLDNERVEAFTAAIEGS-GIEVLDMQHGN--WNRDDAFNVMQDFLSKYPQID 195 (297) T ss_dssp HHHHHHHHHHHHHCCTTCEEEEEECSSSHHHHHHHHHHHHHTTTS-CCEEEEEEECT--TCHHHHHHHHHHHHHHCSCCC T ss_pred HHHHHHHHHHHHHccCCCEEEEEECCCCChHHHHHHHHHHHHhcC-CcEEeecccCC--CCHHHHHHHHHHHHHhCCCCC Confidence 7788888887554 67889988844 345566777888877765 35443221111 1122344455555421 2366 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++.. +..+..+++++++.|+..++.+++. T Consensus 196 ~i~~~~-~~~a~~~~~~l~~~g~~~~~~v~g~ 226 (297) T 4JOQ_A 196 AVWAAD-DDMAIGAMEAIAQAGRTEEMWVMGG 226 (297) T ss_dssp EEECCS-HHHHHHHHHHHHHTTCGGGCEEECC T ss_pred EEEECC-hHHHHHHHHHHHHCCCCCCcEEEec Confidence 666553 4446677788887776323444443 No 144 >4JOQ_B ABC ribose transporter, periplasmic solute-binding; structural genomics, ribose, ABC transporter; HET: MSE; 1.9A {Rhodobacter sphaeroides} Probab=97.56 E-value=6.4e-08 Score=97.68 Aligned_cols=218 Identities=11% Similarity=0.018 Sum_probs=129.3 Template_Neff=12.000 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++.....+++.+++++|+.+ ..+++.+.++ .++ ....+.++ T Consensus 4 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~~~~~-----~~~~~~~~~~-~~~----~~~~~~~~ 61 (297) T 4JOQ_B 4 QEKVGTIGIAIPSATH------------GFMGGLNFHAQDTIKRLQEVY-----PQLDFVLATA-GNA----GKMVNDIE 61 (297) T ss_dssp CCCCEEEEEEEECCSS------------HHHHHHHHHHHHHHHHHHHHC-----TTEEEEEEEE-SSH----HHHHHHHH T ss_pred cccceEEEEEeccCCC------------hhHHHHHHHHHHHHHHHHHHc-----ccccEEEEcC-CCH----HHHHHHHH Confidence 4578999999997642 256677889999999988643 1344444444 222 12223334 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. .++++++|+...+.... .....+...++|+|..+...+. ..++.+++.+++. T Consensus 62 ~l~~------------------~~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~-----~~~~~~~v~~d~~ 118 (297) T 4JOQ_B 62 DMVA------------------TRNISALVVLPFESEPLTSPVQAVKEAGIWVTVVDRGLSV-----EGIEDLYVAGDNP 118 (297) T ss_dssp HHHH------------------HHCCSEEEECCSSHHHHHHHHHHHHHTTCEEEEESSCCSS-----TTCCSEEEEECHH T ss_pred HHHH------------------hCCCCEEEEcCCCCCCCcHHHHHHHHcCCEEEEEeCCCCC-----CCceeEEEEcCch Confidence 3332 14788888765444322 3445566789999987764431 1345677778887 Q NP_000836.2 201 YQAQAMVDIVTAL--GWNYVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~--~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ..++.+++++.+. +.++++++..+ ..++..+.+++++.+++. ++++....... .+..+....++++++. .+++ T Consensus 119 ~~~~~~~~~l~~~~~~~~~i~~l~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~ 195 (297) T 4JOQ_B 119 GFGRVAGEYFAQHLESGKKIVVLRGIPTTLDNERVEAFTAAIEGS-GIEVLDMQHGN--WNRDDAFNVMQDFLSKYPQID 195 (297) T ss_dssp HHHHHHHHHHHHHCCTTCEEEEEECSSSHHHHHHHHHHHHHHTTS-CCEEEEEEECT--TCHHHHHHHHHHHHHHCSCCC T ss_pred HHHHHHHHHHHHHccCCCEEEEEECCCCChHHHHHHHHHHHHhcC-CcEEeecccCC--CCHHHHHHHHHHHHHhCCCCC Confidence 7788888887554 67889988844 345566777888877765 35443221111 1122344455555421 2366 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++.. +..+..+++++++.|+..++.+++. T Consensus 196 ~i~~~~-~~~a~~~~~~l~~~g~~~~~~v~g~ 226 (297) T 4JOQ_B 196 AVWAAD-DDMAIGAMEAIAQAGRTEEMWVMGG 226 (297) T ss_dssp EEECCS-HHHHHHHHHHHHHTTCGGGCEEECC T ss_pred EEEECC-hHHHHHHHHHHHHCCCCCCcEEEec Confidence 666553 4446677788887776323444443 No 145 >5HSG_A Putative ABC transporter, nucleotide binding/ATPase; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: MSE; 1.3A {Klebsiella pneumoniae subsp. pneumoniae} Probab=97.54 E-value=7e-08 Score=98.22 Aligned_cols=214 Identities=10% Similarity=0.040 Sum_probs=121.8 Template_Neff=11.600 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...+.++||++.|..+. .++.....+++.++++.| +++.+.|+..++. ...+.+ T Consensus 21 ~~~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~ 74 (310) T 5HSG_A 21 QSMAGPTYALVQINQQA------------LFFNLMNKGAQDAAKASG----------KDLVIFNSNDNPV----AQNDAI 74 (310) T ss_dssp ----CCSEEEEESCSSS------------HHHHHHHHHHHHHHHHTT----------CCEEEEECTTCHH----HHHHHH T ss_pred ccCCCCEEEEEEecCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCHH----HHHHHH Confidence 44578999999997642 255677788888887653 3344455443322 223344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++++. .+++++|+...+... ......+...++|+|..+...+. .+..+++.+++ T Consensus 75 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~d~ 129 (310) T 5HSG_A 75 ENYIQ-------------------QGVKGILVAAIDVNGIMPAVKEAAAANIPVIAIDAVLPA------GPQAAQVGVDN 129 (310) T ss_dssp HHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCCS------SSCSEEEECCH T ss_pred HHHHH-------------------cCCCEEEEeCCCccccHHHHHHHHHCCCCEEEEccCCCC------CCcceEEEcCh Confidence 44332 477877765443322 23445566789999987654331 24566777777 Q NP_000836.2 200 SYQAQAMVDIVTAL------GWNYVSTLAS-EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE- 271 (908) Q Consensus 200 ~~~~~~~~~~l~~~------~~~~v~ii~~-~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~- 271 (908) ...++.+++++.+. +.++++++.. ++.++..+.++|++.+++.+...+....... .+..+....+++++. T Consensus 130 ~~~~~~~~~~l~~~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~ 207 (310) T 5HSG_A 130 IEGGRIIGQYFVDYVQKEMGGQARLGIVGALNSAIQNQRQKGFEETLKSNPKITIANVVDGQ--NVQDKAMTAAENLITG 207 (310) T ss_dssp HHHHHHHHHHHHHHHHHHSTTCEEEEEEECTTCHHHHHHHHHHHHHHTTCTTEEEC-CEECT--TCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHhCCceEEEEEecCCcHHHHHHHHHHHHHHHhCCCcEEeEeecCC--CCHHHHHHHHHHHHhh Confidence 77777777776544 7789999875 4455667778888887764213332211111 111233445555542 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ..++++|++.. +..+..+++++++.|...++.+++. T Consensus 208 ~~~~~~i~~~~-~~~a~~~~~~~~~~g~~~~i~v~~~ 243 (310) T 5HSG_A 208 NPDLTAIYATG-EPALLGAIAAVENQGRQKDIKVFGW 243 (310) T ss_dssp CTTCCEEEESS-HHHHHHHHHHHHHTTCTTTCEEEEE T ss_pred CCCcCEEEEcC-chHHHHHHHHHHHCCCCCCeEEEEe Confidence 12466666553 4456678888887776323444443 No 146 >2O20_B Catabolite control protein A; ccpa, transcriptional regulator, helix-turn-helix, TRANSCRIPTION; HET: SO4; 1.9A {Lactococcus lactis} Probab=97.51 E-value=8.3e-08 Score=98.76 Aligned_cols=203 Identities=9% Similarity=0.059 Sum_probs=122.1 Template_Neff=11.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++.....+++.++++.+ +++.+.|...++ +...+.++ T Consensus 60 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 113 (332) T 2O20_B 60 SKRTTTVGVILPTITS------------TYFAAITRGVDDIASMYK----------YNMILANSDNDV----EKEEKVLE 113 (332) T ss_dssp ---CCEEEEEESCTTC------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHHH T ss_pred hCCCCEEEEEeCCCCC------------hhHHHHHHHHHHHHHHcC----------CEEEEEeCCCCH----HHHHHHHH Confidence 3568899999987542 255677788888777642 234444544332 22333344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. ++++++|+...+... .....+...++|+|..+...+ .++.+.+..++.. T Consensus 114 ~~~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 166 (332) T 2O20_B 114 TFLS-------------------KQVDGIVYMGSSLDE-KIRTSLKNSRTPVVLVGTIDG-------DKEIPSVNIDYHL 166 (332) T ss_dssp HHHH-------------------TTCSEEEEESSSCCH-HHHHHHHHHTCCEEEESCCCT-------TSCSCEEEECHHH T ss_pred HHHh-------------------CCCCEEEEeCCCCCH-HHHHHHHhCCCCEEEEcCCCC-------CCCCCEEEeCHHH Confidence 3332 478888875544332 444556778999998765432 2345666777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) .++.+++++.+.+.++++++.. ++.++..+.++|++.+++. ++.+..........+..+....+++++. .++|+|+ T Consensus 167 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~d~i~ 244 (332) T 2O20_B 167 AAYQSTKKLIDSGNKKIAYIMGSLKDVENTERMVGYQEALLEA-NIEFDENLVFEGNYSYEQGKALAERLLE-RGATSAV 244 (332) T ss_dssp HHHHHHHHHHHTTCSSEEEECSCTTSHHHHHHHHHHHHHHHHH-TCCCCGGGEECSCCSHHHHHHHHHHHHH-TTCCEEE T ss_pred HHHHHHHHHHHcCCCcEEEEeCCCCcHHHHHHHHHHHHHHHHC-CCCCCHHHeeccCCCHHHHHHHHHHHHH-cCCCEEE Confidence 7778888876668889999985 3345667788888888765 3443321111101112234455666653 4788887 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~ 300 (908) +.. +..+..+++++++.|+. T Consensus 245 ~~~-~~~a~~~~~~l~~~g~~ 264 (332) T 2O20_B 245 VSH-DTVAVGLLSAMMDKGVK 264 (332) T ss_dssp ESC-HHHHHHHHHHHHHTTCC T ss_pred ECC-hHHHHHHHHHHHHCCCC Confidence 654 44566778888887764 No 147 >2O20_F Catabolite control protein A; ccpa, transcriptional regulator, helix-turn-helix, TRANSCRIPTION; HET: SO4; 1.9A {Lactococcus lactis} Probab=97.51 E-value=8.3e-08 Score=98.76 Aligned_cols=203 Identities=9% Similarity=0.059 Sum_probs=123.3 Template_Neff=11.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++.....+++.++++.+ +++.+.|...++ +...+.++ T Consensus 60 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 113 (332) T 2O20_F 60 SKRTTTVGVILPTITS------------TYFAAITRGVDDIASMYK----------YNMILANSDNDV----EKEEKVLE 113 (332) T ss_dssp -CCCCEEEEEESCTTC------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHHH T ss_pred hCCCCEEEEEeCCCCC------------hhHHHHHHHHHHHHHHcC----------CEEEEEeCCCCH----HHHHHHHH Confidence 3568899999987542 255677788888777642 234444544332 22333344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. ++++++|+...+... .....+...++|+|..+...+ .++.+.+..++.. T Consensus 114 ~~~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 166 (332) T 2O20_F 114 TFLS-------------------KQVDGIVYMGSSLDE-KIRTSLKNSRTPVVLVGTIDG-------DKEIPSVNIDYHL 166 (332) T ss_dssp HHHH-------------------TTCSEEEECSSCCCH-HHHHHHHHHTCCEEEESCCCT-------TSCSCEEEECHHH T ss_pred HHHh-------------------CCCCEEEEeCCCCCH-HHHHHHHhCCCCEEEEcCCCC-------CCCCCEEEeCHHH Confidence 3332 478888875544332 444556778999998765432 2345666777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) .++.+++++.+.+.++++++.. ++.++..+.++|++.+++. ++.+..........+..+....+++++. .++|+|+ T Consensus 167 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~d~i~ 244 (332) T 2O20_F 167 AAYQSTKKLIDSGNKKIAYIMGSLKDVENTERMVGYQEALLEA-NIEFDENLVFEGNYSYEQGKALAERLLE-RGATSAV 244 (332) T ss_dssp HHHHHHHHHHHTTCSSEEEECSCTTSHHHHHHHHHHHHHHHHT-TCCCCGGGEECSCCSHHHHHHHHHHHHH-TTCCEEE T ss_pred HHHHHHHHHHHcCCCcEEEEeCCCCcHHHHHHHHHHHHHHHHC-CCCCCHHHeeccCCCHHHHHHHHHHHHH-cCCCEEE Confidence 7778888876668889999985 3345667788888888765 3443321111101112234455666653 4788887 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~ 300 (908) +.. +..+..+++++++.|+. T Consensus 245 ~~~-~~~a~~~~~~l~~~g~~ 264 (332) T 2O20_F 245 VSH-DTVAVGLLSAMMDKGVK 264 (332) T ss_dssp ESS-HHHHHHHHHHHHHTTCC T ss_pred ECC-hHHHHHHHHHHHHCCCC Confidence 654 44566778888887764 No 148 >4YO7_A Sugar ABC transporter (Sugar-binding protein); ENZYME FUNCTION INITIATIVE, EFI, Structural; HET: INS, MSE; 1.7A {Bacillus halodurans} Probab=97.51 E-value=8.5e-08 Score=98.37 Aligned_cols=216 Identities=14% Similarity=0.082 Sum_probs=126.6 Template_Neff=11.700 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++.++||++.|..+. ++....++++.++++.| + +++.+.|+..++. ...+. T Consensus 40 ~~~~~~~~Igv~~~~~~~-------------~~~~~~~~~~~~~~~~~-------~--~~~~~~~~~~~~~----~~~~~ 93 (326) T 4YO7_A 40 TGDSGQKVIGVSISNLDE-------------FLTYMQDAMKEEAANYP-------D--FEFIFSDAQNDST----QQMAQ 93 (326) T ss_dssp CCCCCCEEEEEEESCCCH-------------HHHHHHHHHHHHHTTCT-------T--EEEEEEECTTCHH----HHHHH T ss_pred cccCCCeEEEEEECCccH-------------HHHHHHHHHHHHHHhCC-------C--CEEEEecCCCCHH----HHHHH Confidence 456788999999987632 45567778888777754 2 3445555544422 23333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+... ......+...++|+|..+...+. ..++++++.++ T Consensus 94 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~-----~~~~~~~v~~d 149 (326) T 4YO7_A 94 VENFIS-------------------RNVDAIIVNPVDTTSAVDIVNMVNDAGIPIIIANRTFDG-----VDQATAFVGSE 149 (326) T ss_dssp HHHHHH-------------------HTCSEEEECCSCHHHHHHHHHHHHHHTCCEEEESCCCTT-----GGGSSEEEECC T ss_pred HHHHHh-------------------CCCCEEEEcCCCcchhHHHHHHHHHCCCCEEEEccCCCC-----CccccEEEccc Confidence 443332 467877765443332 24445566789999987654331 13456777777 Q NP_000836.2 199 DSYQAQAMVDIVTA--LGWNYVSTLASE--GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TP 273 (908) Q Consensus 199 ~~~~~~~~~~~l~~--~~~~~v~ii~~~--~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~ 273 (908) +...++.+++++.+ .+.++++++..+ ..++..+.+++++.+++.+++++....... .+..+....++++++ .. T Consensus 150 ~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 227 (326) T 4YO7_A 150 SIQSGLLQMEEVAKLLNNEGNIAIMDGELGHEAQIMRTEGNKQIIEEHDGLEVVLQGTAK--FDRSEGMRLMENWLNSGT 227 (326) T ss_dssp HHHHHHHHHHHHHHHTTTCEEEEEEECSTTCHHHHHHHHHHHHHHHTCTTEEEEEEEECT--TCHHHHHHHHHHHHHTTC T ss_pred hHHHHHHHHHHHHHHhCCCceEEEEECCCCCHHHHHHHHHHHHHHHhCCCeeEEEeccCC--CCHHHHHHHHHHHHHhCC Confidence 77777788887755 467899999853 235667777888877654223433211111 111233444555542 13 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|+|+... +..+..+++++++.|...++.+++. T Consensus 228 ~~d~i~~~~-~~~~~~~~~~l~~~g~~~~i~iv~~ 261 (326) T 4YO7_A 228 EIDAVVANN-DEMALGAILALEAVGKLDDVIVAGI 261 (326) T ss_dssp CCSEEEESS-HHHHHHHHHHHHHTTCGGGSEEECS T ss_pred CCCEEEECC-hHHHHHHHHHHHHCCCCCCeEEEEe Confidence 577776654 4456678888888776323444444 No 149 >6GQ0_A Putative sugar binding protein; Glucose-galactose binding protein, Gebacillus stearothermophilus; 1.94A {Geobacillus stearothermophilus} Probab=97.49 E-value=9.5e-08 Score=97.65 Aligned_cols=220 Identities=12% Similarity=0.077 Sum_probs=123.4 Template_Neff=11.400 Q NP_000836.2 35 EYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALE 114 (908) Q Consensus 35 ~~~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~ 114 (908) .........++++||++.|..+. .++.....+++.++++.+ +++.+...+. .++ + T Consensus 20 ~~~~~~~~~~~~~I~vv~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~ 74 (318) T 6GQ0_A 20 KERVPETTKEAYHFVLVPEELDN------------DYWRLVEKGAKAAAKELG--------VDLEYIGPRQ-ANI----D 74 (318) T ss_dssp --------CCCCEEEEECSCSSC------------HHHHHHHHHHHHHHHHHT--------CEEEECCCSS-CCH----H T ss_pred ccCCCCCCCCcEEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC--------CEEEEECCCc-cCH----H Confidence 33444567788999999885432 245677788888887753 3444443322 221 1 Q NP_000836.2 115 QSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFS 193 (908) Q Consensus 115 ~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~ 193 (908) ...+.+++++. ++++++|+...+.... .....+...++|+|..+...+. .++++ T Consensus 75 ~~~~~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~ 129 (318) T 6GQ0_A 75 EHLRILKKAAA-------------------AKVDGIITQGLTEAEFVPVINEITDKNIPVVTIDTDAPT------SRRVA 129 (318) T ss_dssp HHHHHHHHHHH-------------------TTCSEEEECCCBHHHHHHHHHHHHTTTCCEEEESSCCTT------SCCSE T ss_pred HHHHHHHHHHH-------------------CCCCEEEECCCCHHHhHHHHHHHHHCCCCEEEEeCCCCc------ccceE Confidence 22333443332 4788887654433221 3344566679999987654321 24567 Q NP_000836.2 194 RVVPPDSYQAQAMVDIVTA--LGWNYVSTLASEGN--YGESGVEAFTQISRE-IGGVCIAQSQKIPREPRPGEFEKIIKR 268 (908) Q Consensus 194 ~~~~~~~~~~~~~~~~l~~--~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~-~~~i~v~~~~~~~~~~~~~~~~~~~~~ 268 (908) ++.+++...+..+++++.+ .+.++++++..+.. ++..+.+++++.+++ . ++.+....... .+..+....+.+ T Consensus 130 ~v~~~~~~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~ 206 (318) T 6GQ0_A 130 YVGTDNYYAGFLAGRALAEDTKGKATVAIITGSLTAAHQQLRVRGFEDAVRQEK-GIRIVAIEESH--ITRVQAAEKAYT 206 (318) T ss_dssp EEEECHHHHHHHHHHHHHHHTTTCEEEEEEESCSSBHHHHHHHHHHHHHHTTCT-TEEEEEEEECT--TCHHHHHHHHHH T ss_pred EEEcChHHHHHHHHHHHHHHcCCCcEEEEEECCCCcHHHHHHHHHHHHHHHhcC-CeEEEEEEecC--CCHHHHHHHHHH Confidence 7777777778888888765 57889999985433 455677777777765 3 34443211111 111223344455 Q NP_000836.2 269 LLET-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 269 l~~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +++. .++++|++.. +..+..+++++++.|+..++.+++. T Consensus 207 ~l~~~~~~~~i~~~~-~~~a~~~~~~l~~~g~~~~i~i~~~ 246 (318) T 6GQ0_A 207 ILKKHPDVNAFYGTS-ALDAIGVAKVVEQFHREQKTYIIGF 246 (318) T ss_dssp HHHHCTTCCEEEECS-TTHHHHHHHHHHHTTCGGGCEEEEE T ss_pred HHHHCCCcCEEEEcC-cchHHHHHHHHHHcCCCCCeEEEEe Confidence 5421 2678876665 3556678888887776323444443 No 150 >6GT9_C Putative sugar binding protein; Glucose-galactose binding protein, Geobacillus stearothermophilus; HET: SO4, GAL; 1.894A {Geobacillus stearothermophilus} Probab=97.49 E-value=9.5e-08 Score=97.65 Aligned_cols=220 Identities=12% Similarity=0.077 Sum_probs=125.3 Template_Neff=11.400 Q NP_000836.2 35 EYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALE 114 (908) Q Consensus 35 ~~~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~ 114 (908) .........++++||++.|..+. .++.....+++.++++.+ +++.+...+. .++ + T Consensus 20 ~~~~~~~~~~~~~I~vv~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~ 74 (318) T 6GT9_C 20 KERVPETTKEAYHFVLVPEELDN------------DYWRLVEKGAKAAAKELG--------VDLEYIGPRQ-ANI----D 74 (318) T ss_dssp -----CCSTTSCEEEEECSSTTC------------HHHHHHHHHHHHHHHHHT--------CEEEECCCSS-CCH----H T ss_pred ccCCCCCCCCcEEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC--------CEEEEECCCc-cCH----H Confidence 33444567788999999885432 245677788888887753 3444443322 221 1 Q NP_000836.2 115 QSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFS 193 (908) Q Consensus 115 ~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~ 193 (908) ...+.+++++. ++++++|+...+.... .....+...++|+|..+...+. .++++ T Consensus 75 ~~~~~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~ 129 (318) T 6GT9_C 75 EHLRILKKAAA-------------------AKVDGIITQGLTEAEFVPVINEITDKNIPVVTIDTDAPT------SRRVA 129 (318) T ss_dssp HHHHHHHHHHH-------------------TTCSEEEECCCCHHHHHHHHHHHHHTTCCEEEESSCCTT------SCCSE T ss_pred HHHHHHHHHHH-------------------CCCCEEEECCCCHHHhHHHHHHHHHCCCCEEEEeCCCCc------ccceE Confidence 22333443332 4788887654433221 3344566679999987654321 24567 Q NP_000836.2 194 RVVPPDSYQAQAMVDIVTA--LGWNYVSTLASEGN--YGESGVEAFTQISRE-IGGVCIAQSQKIPREPRPGEFEKIIKR 268 (908) Q Consensus 194 ~~~~~~~~~~~~~~~~l~~--~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~-~~~i~v~~~~~~~~~~~~~~~~~~~~~ 268 (908) ++.+++...+..+++++.+ .+.++++++..+.. ++..+.+++++.+++ . ++.+....... .+..+....+.+ T Consensus 130 ~v~~~~~~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~ 206 (318) T 6GT9_C 130 YVGTDNYYAGFLAGRALAEDTKGKATVAIITGSLTAAHQQLRVRGFEDAVRQEK-GIRIVAIEESH--ITRVQAAEKAYT 206 (318) T ss_dssp EEECCHHHHHHHHHHHHHHHTTTEEEEEEEESCSSCHHHHHHHHHHHHHHTTCT-EEEEEEEEECT--TCHHHHHHHHHH T ss_pred EEEcChHHHHHHHHHHHHHHcCCCcEEEEEECCCCcHHHHHHHHHHHHHHHhcC-CeEEEEEEecC--CCHHHHHHHHHH Confidence 7777777778888888765 57889999985433 455677777777765 3 34443211111 111223344455 Q NP_000836.2 269 LLET-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 269 l~~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +++. .++++|++.. +..+..+++++++.|+..++.+++. T Consensus 207 ~l~~~~~~~~i~~~~-~~~a~~~~~~l~~~g~~~~i~i~~~ 246 (318) T 6GT9_C 207 ILKKHPDVNAFYGTS-ALDAIGVAKVVEQFHREQKTYIIGF 246 (318) T ss_dssp HHHHCTTCCEEEECS-TTHHHHHHHHHHHHCCSSCCEEEEE T ss_pred HHHHCCCcCEEEEcC-cchHHHHHHHHHHcCCCCCeEEEEe Confidence 5421 2678876665 3556678888887776323444443 No 151 >1GUB_A D-ALLOSE-BINDING PERIPLASMIC PROTEIN; SUGAR-BINDING PROTEIN, PERIPLASMIC BINDING PROTEIN; 3.1A {ESCHERICHIA COLI} SCOP: c.93.1.1 Probab=97.48 E-value=1e-07 Score=95.59 Aligned_cols=218 Identities=11% Similarity=0.073 Sum_probs=124.4 Template_Neff=12.200 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++. |+++.+...|+..++. ...+.++++. T Consensus 1 ~i~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~~~~~~~~~~~~~~----~~~~~~~~l~ 56 (288) T 1GUB_A 1 AAEYAVVLKTLSN------------PFWVDMKKGIEDEAKTL--------GVSVDIFASPSEGDFQ----SQLQLFEDLS 56 (288) T ss_dssp CCSEEEEESCSSS------------HHHHHHHHHHHHHHHHH--------TCCEEEEECSSTTCHH----HHHHHHHHHH T ss_pred CceEEEEEccCCC------------HHHHHHHHHHHHHHHHh--------CCEEEEEcCCCCCCHH----HHHHHHHHHH Confidence 4789999987542 25567778888888775 3455555554333321 2233344333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSD-NTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~-~~~~~~~~~~~~~~~~~ 202 (908) . ++++++|+...+.... .....+...++|+|..+...+.... ....++++++.+++... T Consensus 57 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~~~~~~~~~~~v~~~~~~~ 117 (288) T 1GUB_A 57 N-------------------KNYKGIAFAPLSSVNLVMPVARAWKKGIYLVNLDEKIDMDNLKKAGGNVEAFVTTDNVAV 117 (288) T ss_dssp T-------------------SCCSEEEECCSSTTTTHHHHHHHHHHTCEEEEESSCCCHHHHHHHTCCCSEEEECCHHHH T ss_pred c-------------------CCCCEEEEecCCcccchHHHHHHHHCCCeEEEECCCCChHHHhhcCCceEEEEecChHHH Confidence 2 4788777654433221 3345566789999987764431100 00135667788888777 Q NP_000836.2 203 AQAMVDIVTAL-GW--NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 203 ~~~~~~~l~~~-~~--~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ++.+++++.+. +. +++++++. ++.++..+.+++++.+++.+.+.+....... .+..+....++++++. .+++ T Consensus 118 ~~~~~~~l~~~~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~ 195 (288) T 1GUB_A 118 GAKGASFIIDKLGAEGGEVAIIEGKAGNASGEARRNGATEAFKKASQIKLVASQPAD--WDRIKALDVATNVLQRNPNIK 195 (288) T ss_dssp HHHHHHHHHHHHTTTCEEEEEECCCSSCHHHHHHHHHHHHHHHHCTTEEEEEEECCC--SCHHHHHHHHHHHHHHCTTEE T ss_pred HHHHHHHHHHHHhhCCceEEEEEcCCCCccHHHHHHHHHHHHHhcCCcEEeeccCCC--CcHHHHHHHHHHHHHHCCCcC Confidence 88888887553 66 88999985 3345667778888887764213332211111 1112334445555421 2466 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++.. +..+..+++++++.|+..++.+++. T Consensus 196 ~i~~~~-~~~~~~~~~~~~~~g~~~~~~i~~~ 226 (288) T 1GUB_A 196 AIYCAN-DTMAMGVAQAVANAGKTGKVLVVGT 226 (288) T ss_dssp EEEESS-HHHHHHHHHHHHHHTCBTTBEEEEE T ss_pred EEEECC-cccHHHHHHHHHHcCCCCCeEEEEe Confidence 676654 4456678888888776323444444 No 152 >1GUD_B D-ALLOSE-BINDING PERIPLASMIC PROTEIN; PERIPLASMIC BINDING PROTEIN, ALLOSE, HINGE; 1.71A {ESCHERICHIA COLI} SCOP: c.93.1.1 Probab=97.48 E-value=1e-07 Score=95.59 Aligned_cols=218 Identities=11% Similarity=0.073 Sum_probs=124.4 Template_Neff=12.200 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++. |+++.+...|+..++. ...+.++++. T Consensus 1 ~i~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~~~~~~~~~~~~~~----~~~~~~~~l~ 56 (288) T 1GUD_B 1 AAEYAVVLKTLSN------------PFWVDMKKGIEDEAKTL--------GVSVDIFASPSEGDFQ----SQLQLFEDLS 56 (288) T ss_dssp CCEEEEECSCSSS------------HHHHHHHHHHHHHHHHH--------TCEEEEECCSSTTCHH----HHHHHHHHHH T ss_pred CceEEEEEccCCC------------HHHHHHHHHHHHHHHHh--------CCEEEEEcCCCCCCHH----HHHHHHHHHH Confidence 4789999987542 25567778888888775 3455555554333321 2233344333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSD-NTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~-~~~~~~~~~~~~~~~~~ 202 (908) . ++++++|+...+.... .....+...++|+|..+...+.... ....++++++.+++... T Consensus 57 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~~~~~~~~~~~v~~~~~~~ 117 (288) T 1GUD_B 57 N-------------------KNYKGIAFAPLSSVNLVMPVARAWKKGIYLVNLDEKIDMDNLKKAGGNVEAFVTTDNVAV 117 (288) T ss_dssp T-------------------TCCSEEEECCSSSSTTHHHHHHHHHTTCEEEEESSCCCHHHHHHTTCCCSEEEECCHHHH T ss_pred c-------------------CCCCEEEEecCCcccchHHHHHHHHCCCeEEEECCCCChHHHhhcCCceEEEEecChHHH Confidence 2 4788777654433221 3345566789999987764431100 00135667788888777 Q NP_000836.2 203 AQAMVDIVTAL-GW--NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 203 ~~~~~~~l~~~-~~--~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ++.+++++.+. +. +++++++. ++.++..+.+++++.+++.+.+.+....... .+..+....++++++. .+++ T Consensus 118 ~~~~~~~l~~~~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~ 195 (288) T 1GUD_B 118 GAKGASFIIDKLGAEGGEVAIIEGKAGNASGEARRNGATEAFKKASQIKLVASQPAD--WDRIKALDVATNVLQRNPNIK 195 (288) T ss_dssp HHHHHHHHHHHHTTTCEEEEEEECSTTCHHHHHHHHHHHHHHHTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHCTTEE T ss_pred HHHHHHHHHHHHhhCCceEEEEEcCCCCccHHHHHHHHHHHHHhcCCcEEeeccCCC--CcHHHHHHHHHHHHHHCCCcC Confidence 88888887553 66 88999985 3345667778888887764213332211111 1112334445555421 2466 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++.. +..+..+++++++.|+..++.+++. T Consensus 196 ~i~~~~-~~~~~~~~~~~~~~g~~~~~~i~~~ 226 (288) T 1GUD_B 196 AIYCAN-DTMAMGVAQAVANAGKTGKVLVVGT 226 (288) T ss_dssp EEEESS-HHHHHHHHHHHHHTTCBTTBEEEEE T ss_pred EEEECC-cccHHHHHHHHHHcCCCCCeEEEEe Confidence 676654 4456678888888776323444444 No 153 >1DBQ_B PURINE REPRESSOR; TRANSCRIPTION REGULATION, DNA-BINDING REGULATORY PROTEIN; 2.2A {Escherichia coli} SCOP: c.93.1.1 Probab=97.47 E-value=1.1e-07 Score=95.41 Aligned_cols=205 Identities=14% Similarity=0.122 Sum_probs=114.3 Template_Neff=12.200 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++.....+++.++++.+ +++.+.|+..++ +...+.++ T Consensus 4 ~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~~----------~~~~~~~~~~~~----~~~~~~~~ 57 (289) T 1DBQ_B 4 VNHTKSIGLLATSSEA------------AYFAEIIEAVEKNCFQKG----------YTLILGNAWNNL----EKQRAYLS 57 (289) T ss_dssp ----CEEEEEESCSSC------------TTTTHHHHHHHHHHHHTT----------CEEEEEECSSCT----THHHHHHH T ss_pred cCCccEEEEEcCCCcc------------hHHHHHHHHHHHHHHHhC----------CeEEEEecCCCH----HHHHHHHH Confidence 4567899999987542 245567777777776542 334445544332 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILR-LFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~-~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. .+++++|+...+... .....+. ..++|+|..+...+. .++.+++.+++. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~~~~ 111 (289) T 1DBQ_B 58 MMAQ-------------------KRVDGLLVMCSEYPE-PLLAMLEEYRHIPMVVMDWGEAK------ADFTDAVIDNAF 111 (289) T ss_dssp HHHH-------------------TTCSCCCEECSCCCH-HHHHHHHHTTTSCCCEEEESCCC------SSSCEEEECCHH T ss_pred HHHh-------------------cCCCEEEEecCCCCH-HHHHHHHHhCCCCEEEecCCCCC------CCCCcEEEeCHH Confidence 3332 478888875443322 2223333 479999987654321 234456667766 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ..++.+++++.+.+.++++++.. +..++..+.++|.+.+++. ++.+........+.+..+....++++++. .++++ T Consensus 112 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 190 (289) T 1DBQ_B 112 EGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEA-MIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTA 190 (289) T ss_dssp HHHHHHHHHHHHTTCCSEEEECCC------CHHHHHHHHHHHHH-TCCCCGGGBCCCCSSHHHHHHHHHHHHSSSSCCSE T ss_pred HHHHHHHHHHHHCCCCcEEEEeCCCcccchHHHHHHHHHHHHHC-CCCCCHHHeeecCCChHHHHHHHHHHHcCCCCCCE Confidence 77788888887668889999985 3345667778888887765 34443211111001112334445555431 24677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 191 v~~~~-~~~a~~~~~~l~~~g~~ 212 (289) T 1DBQ_B 191 VFCGG-DIMAMGALCAADEMGLR 212 (289) T ss_dssp EEESC-HHHHHHHHHHHHHHTCC T ss_pred EEECC-HHHHHHHHHHHHHcCCC Confidence 76654 33566778888877764 No 154 >4RK0_D LacI family sugar-binding transcriptional regulator; sugar binding, transcription regulation, Enzyme; HET: RIB; 1.8A {Enterococcus faecalis V583} Probab=97.45 E-value=1.2e-07 Score=94.24 Aligned_cols=198 Identities=12% Similarity=0.122 Sum_probs=121.1 Template_Neff=12.100 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++..+..+++.++++. | +++.+.|+..++. ...+.++ T Consensus 4 ~~~~~~I~~~~~~~~~------------~~~~~~~~g~~~~~~~~--------~--~~~~~~~~~~~~~----~~~~~~~ 57 (274) T 4RK0_D 4 MKKSKTIGVIVPDITN------------PFFAQLIRGIESVLYKE--------N--FILILCNADQDVT----REHEYLT 57 (274) T ss_dssp --CCEEEEEEESCTTS------------HHHHHHHHHHHHHHTTT--------T--EEEEEEEGGGCCS----TTCHHHH T ss_pred CCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHC--------C--CEEEEEeCCCChH----HHHHHHH Confidence 4567899999987542 25667788888887764 2 3445555543322 2333444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+.....+...+...++|+|..+...+ .++.+++.+++.. T Consensus 58 ~~~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~~ 111 (274) T 4RK0_D 58 ELIR-------------------RSVDGFVIASSEISNQTINETLRAKKIPFIVLDQKKA-------EGFSDAVLTDDYR 111 (274) T ss_dssp HHHT-------------------SCCSEEEECCTTSCHHHCCCCCCHHTCCEEEETTSCC-------CSSSEEEEECHHH T ss_pred HHHH-------------------cCCCEEEEeCcccCchHHHHHHHHCCCCEEEEcCCCC-------CCCCcEEEechHH Confidence 4332 4788888765544333444556778999998765432 1356677788877 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) .++.+++++.+.+.++++++..+.. ++..+.++|++.+++. +..+.. .+. ..+....+++++. .++|+|+ T Consensus 112 ~~~~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~--~~~----~~~~~~~~~~~~~-~~~~~i~ 183 (274) T 4RK0_D 112 GGQLAAKHLQEQRHEQVIVVMPPHAPVNIQQRLKGFCSVYTEK-VQLIET--ELS----KTGGYQAVPEILK-TESTGIF 183 (274) T ss_dssp HHHHHHHHHHHTTCCSEEEEECSSCCHHHHHHHHHHHTTCCSS-EEEEEC--CSS----HHHHHHHHHHHHT-SCCCEEE T ss_pred HHHHHHHHHHHCCCCeEEEeCCCCCchHHHHHHHHHHHHHHhc-cceecc--ccc----ccchhhHHHHHHh-cCCCEEE Confidence 8888888886666788999885433 5566777888777664 222111 111 1123344555553 3788887 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~ 300 (908) +.. +..+..+++++++.|+. T Consensus 184 ~~~-~~~~~~~~~~~~~~g~~ 203 (274) T 4RK0_D 184 AIN-DEIAFGLYRGLAEAGKK 203 (274) T ss_dssp ESS-HHHHHHHHHHHHHTTCC T ss_pred EcC-hHHHHHHHHHHHHcCCC Confidence 764 33466788888877764 No 155 >3DBI_A SUGAR-BINDING TRANSCRIPTIONAL REGULATOR, LACI FAMILY; STRUCTURAL GENOMICS, SUGAR-BINDING TRANSCRIPTIONAL REGULATOR; HET: MSE, PO4; 2.45A {Escherichia coli K12} Probab=97.45 E-value=1.3e-07 Score=97.60 Aligned_cols=207 Identities=10% Similarity=0.026 Sum_probs=121.5 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|..+.. ..++.....+++.++++.+ +++.+.|+..++ +...+.++ T Consensus 58 ~~~~~~Ig~i~~~~~~~----------~~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 113 (338) T 3DBI_A 58 AKSTQTLGLVVTNTLYH----------GIYFSELLFHAARMAEEKG----------RQLLLADGKHSA----EEERQAIQ 113 (338) T ss_dssp --CCSEEEEEECTTTTS----------TTHHHHHHHHHHHHHHHTT----------CEEEEEECTTSH----HHHHHHHH T ss_pred cCCCCeEEEEecCcccc----------CccHHHHHHHHHHHHHHcC----------CEEEEEcCCCCH----HHHHHHHH Confidence 35688999999976421 1255667778887777642 344455554442 22333444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .+++++|+...+.....+...++..++|+|.++...+. +..+.+..++.. T Consensus 114 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-------~~~~~v~~~~~~ 167 (338) T 3DBI_A 114 YLLD-------------------LRCDAIMIYPRFLSVDEIDDIIDAHSQPIMVLNRRLRK-------NSSHSVWCDHKQ 167 (338) T ss_dssp HHHH-------------------TTCSEEEECCSSSCHHHHHHHHHHCSSCEEEESSCCSS-------SGGGEECBCHHH T ss_pred HHHh-------------------cCCCEEEEeCCCCChHHHHHHHHhcCCCEEEECCCCCC-------CCCcEEEeCCHH Confidence 4432 47888887654433334445566789999987754321 234555666666 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .+..+++++.+.+.++++++..+.. ++..+.++|++.+++. ++.+.....+..+.+..+..+.+++++. ..++|+| T Consensus 168 ~~~~~~~~l~~~g~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d~v 246 (338) T 3DBI_A 168 TSFNAVAELINAGHQEIAFLTGSMDSPTSIERLAGYKDALAQH-GIALNEKLIANGKWTPASGAEGVEMLLERGAKFSAL 246 (338) T ss_dssp HHHHHHHHHHHTTCCSEEEECCCTTCHHHHHHHHHHHHHHHHT-TCCCCGGGEECCCSSHHHHHHHHHHHHHTTCCCSEE T ss_pred HHHHHHHHHHHCCCCcEEEEecCCCCchHHHHHHHHHHHHHHC-CCCCCHHHeecCCCChHHHHHHHHHHHHCCCCCCEE Confidence 6777777776668889999986443 5667778888888765 3444321111100112233444555542 1247777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 247 ~~~~-~~~a~~~~~~l~~~g~~ 267 (338) T 3DBI_A 247 VASN-DDMAIGAMKALHERGVA 267 (338) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHCCCC Confidence 7664 44567778888887764 No 156 >3DBI_C SUGAR-BINDING TRANSCRIPTIONAL REGULATOR, LACI FAMILY; STRUCTURAL GENOMICS, SUGAR-BINDING TRANSCRIPTIONAL REGULATOR; HET: MSE, PO4; 2.45A {Escherichia coli K12} Probab=97.45 E-value=1.3e-07 Score=97.60 Aligned_cols=207 Identities=10% Similarity=0.026 Sum_probs=121.5 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|..+.. ..++.....+++.++++.+ +++.+.|+..++ +...+.++ T Consensus 58 ~~~~~~Ig~i~~~~~~~----------~~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 113 (338) T 3DBI_C 58 AKSTQTLGLVVTNTLYH----------GIYFSELLFHAARMAEEKG----------RQLLLADGKHSA----EEERQAIQ 113 (338) T ss_dssp --CCSEEEEEECTTTTS----------SSHHHHHHHHHHHHHHHTT----------CEEEEEECTTSH----HHHHHHHH T ss_pred cCCCCeEEEEecCcccc----------CccHHHHHHHHHHHHHHcC----------CEEEEEcCCCCH----HHHHHHHH Confidence 35688999999976421 1255667778887777642 344455554442 22333444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .+++++|+...+.....+...++..++|+|.++...+. +..+.+..++.. T Consensus 114 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-------~~~~~v~~~~~~ 167 (338) T 3DBI_C 114 YLLD-------------------LRCDAIMIYPRFLSVDEIDDIIDAHSQPIMVLNRRLRK-------NSSHSVWCDHKQ 167 (338) T ss_dssp HHHH-------------------TTCSEEEECCSSSCHHHHHHHHHHCSSCEEEESSCCSS-------SGGGEECBCHHH T ss_pred HHHh-------------------cCCCEEEEeCCCCChHHHHHHHHhcCCCEEEECCCCCC-------CCCcEEEeCCHH Confidence 4432 47888887654433334445566789999987754321 234555666666 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .+..+++++.+.+.++++++..+.. ++..+.++|++.+++. ++.+.....+..+.+..+..+.+++++. ..++|+| T Consensus 168 ~~~~~~~~l~~~g~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d~v 246 (338) T 3DBI_C 168 TSFNAVAELINAGHQEIAFLTGSMDSPTSIERLAGYKDALAQH-GIALNEKLIANGKWTPASGAEGVEMLLERGAKFSAL 246 (338) T ss_dssp HHHHHHHHHHHTTCCSEEEECCCTTCHHHHHHHHHHHHHHHHT-TCCCCGGGEECCCSSHHHHHHHHHHHHHTTCCCSEE T ss_pred HHHHHHHHHHHCCCCcEEEEecCCCCchHHHHHHHHHHHHHHC-CCCCCHHHeecCCCChHHHHHHHHHHHHCCCCCCEE Confidence 6777777776668889999986443 5667778888888765 3444321111100112233444555542 1247777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 247 ~~~~-~~~a~~~~~~l~~~g~~ 267 (338) T 3DBI_C 247 VASN-DDMAIGAMKALHERGVA 267 (338) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHCCCC Confidence 7664 44567778888887764 No 157 >3EGC_F putative ribose operon repressor; STRUCTURAL GENOMICS, UNKNOWN FUNCTION, DNA-binding; 2.35A {Burkholderia thailandensis} Probab=97.42 E-value=1.5e-07 Score=94.64 Aligned_cols=205 Identities=11% Similarity=0.054 Sum_probs=119.7 Template_Neff=11.700 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++.++||++.|..+. .++.....+++.++++.+ +++.+.++..++. ...+.+ T Consensus 4 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~~----~~~~~~ 57 (291) T 3EGC_F 4 RSKRSNVVGLIVSDIEN------------VFFAEVASGVESEARHKG----------YSVLLANTAEDIV----REREAV 57 (291) T ss_dssp ---CCCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCHH----HHHHHH T ss_pred cCCCCcEEEEEEcCccc------------HHHHHHHHHHHHHHHHcC----------CeEEEEECCCCHH----HHHHHH Confidence 34578999999987542 256677888888887753 2344445433321 223334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .+++++|+...+.. ......+...++|+|..+...+ .++.+.+.++.. T Consensus 58 ~~l~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~ 110 (291) T 3EGC_F 58 GQFFE-------------------RRVDGLILAPSEGE-HDYLRTELPKTFPIVAVNRELR-------IPGCGAVLSENV 110 (291) T ss_dssp HHHHH-------------------TTCSEEEECCCSSC-CHHHHHSSCTTSCEEEESSCCC-------CTTCEEEEECHH T ss_pred HHHHH-------------------cCCCEEEEeCCCCC-hHHHHhhcCCCCCEEEECCCCC-------CCCCcEEEeCcH Confidence 43332 47888887654433 3344556678999998776433 134667777777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) ..++.+++++.+.+.++++++.. ++.....+.++|++.+++. ++++........+.+..+....+++++. ..++++ T Consensus 111 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ 189 (291) T 3EGC_F 111 RGARTAVEYLIARGHTRIGAIVGSAGLMTSRERLKGFRAAMSAA-GLPVRQEWIAAGGVRADNGRDGAIKVLTGADRPTA 189 (291) T ss_dssp HHHHHHHHHHHHTTCCSEEEECSSTTSHHHHHHHHHHHHHHHHT-TCCCCGGGEEC------CCHHHHHHHHTSTTCCSE T ss_pred HHHHHHHHHHHHCCCCcEEEEeCCCCcccHHHHHHHHHHHHHHc-CCCCChheEeecCCchhhHHHHHHHHHhCCCCCCE Confidence 77778888876668889999985 3345566778888888765 3443321111100111122334444432 135777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 190 i~~~~-~~~a~~~~~~l~~~g~~ 211 (291) T 3EGC_F 190 LLTSS-HRITEGAMQALNVLGLR 211 (291) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHcCCC Confidence 77664 44466777888877764 No 158 >4KZK_A L-arabinose-binding protein; L-arabinose, BETA-D-GALACTOSE, ABC transporter, periplasmic; HET: GAL; 1.5A {Burkholderia thailandensis} Probab=97.41 E-value=1.6e-07 Score=96.80 Aligned_cols=218 Identities=11% Similarity=0.069 Sum_probs=122.1 Template_Neff=11.900 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+.++||++.|..+. .++.....+++.++++.+ +++.+.|+ .++ +...+. T Consensus 31 ~~~~~~~~Ig~~~~~~~~------------~~~~~~~~~~~~a~~~~~----------~~~~~~~~-~~~----~~~~~~ 83 (337) T 4KZK_A 31 AQGAAPVKIGFVVKQPDD------------PWFQDEWRFAEQAAKDKH----------FTLVKIAA-PSG----EKVSTA 83 (337) T ss_dssp ------CEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT----------CEEEEEEC-CSH----HHHHHH T ss_pred hcCCCCeEEEEEECCCCC------------HHHHHHHHHHHHHHHHcC----------CEEEEEeC-CCH----HHHHHH Confidence 455678999999985432 245667778888877652 33444454 332 222333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+.. .......+...++|+|.++...+.... ...++++++.++ T Consensus 84 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~-~~~~~~~~v~~d 143 (337) T 4KZK_A 84 LDSLAA-------------------QKAQGVIICAPDVKLGPGIAAKAKRYGMKLMSVDDQLVDGRG-APLADVPHMGIS 143 (337) T ss_dssp HHHHHH-------------------TTCSEEEEECSSGGGHHHHHHHHHHTTCEEEEESSCCBCTTS-CBCTTSCEEEEC T ss_pred HHHHHh-------------------cCCCEEEEcCCCCcccHHHHHHHHHcCCEEEEEecCCCCCCC-CCcccCcEEecC Confidence 443332 47787776544332 233445667789999988765432111 113567777788 Q NP_000836.2 199 DSYQAQAMVDIVTA----LGWN--YVSTLASE---GNYGESGVEAFTQISREIGGVC---IAQSQKIPREPRPGEFEKII 266 (908) Q Consensus 199 ~~~~~~~~~~~l~~----~~~~--~v~ii~~~---~~~~~~~~~~~~~~~~~~~~i~---v~~~~~~~~~~~~~~~~~~~ 266 (908) +...++.+++++.+ .+++ +++++..+ +.++..+.++|++.+++. +.. +....... .+..+....+ T Consensus 144 ~~~~~~~~~~~l~~~~~~~g~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~--~~~~~~~~~~ 220 (337) T 4KZK_A 144 AYRIGRQVGDAIAAEAKRRGWNPAEVGVLRLAYDQLPTARERTTGAVDALKAA-GFAAANVVDAPEMT--ADTEGAFNAA 220 (337) T ss_dssp HHHHHHHHHHHHHHHHHHTTCCGGGCEEEEEECTTSHHHHHHHHHHHHHHHHT-TCCGGGEEEEECSS--SSHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHcCCCCccEEEEEecCCCChHHHHHHHHHHHHHHHc-CCccceeeccccCC--CCHHHHHHHH Confidence 77778888887754 4666 89998754 456667788888888765 333 22111111 1122344555 Q NP_000836.2 267 KRLLETPNARA---VIMFANEDDIRRILEAAKKLNQSG-HFLWIGS 308 (908) Q Consensus 267 ~~l~~~~~~~v---iv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~ 308 (908) +++++ .+++. +++..++..+..+++++++.|+.. ++.+++. T Consensus 221 ~~~~~-~~~~~~~~~i~~~~~~~a~~~~~~l~~~g~~~~~i~i~g~ 265 (337) T 4KZK_A 221 NIAFT-KHRNFRHWVAFGSNDDTTVGAVRAGEGRGIGTDDMIAVGI 265 (337) T ss_dssp HHHHH-HCTTCSSEEEECSSHHHHHHHHHHHHHTTCCGGGEEEEEE T ss_pred HHHHH-hCCCCCeEEEEecChHHHHHHHHHHHHcCCCCCCeEEEEe Confidence 66653 34443 233334555677888888877631 3444443 No 159 >3O1I_C Sensor protein TorS (E.C.2.7.13.3), Periplasmic; Ligand free, Two component sensor; HET: PE4; 2.8A {Vibrio parahaemolyticus} Probab=97.41 E-value=1.6e-07 Score=95.14 Aligned_cols=216 Identities=7% Similarity=-0.002 Sum_probs=120.4 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||++.|.... ..+..+..+++.++++.+ +++.+...|...++. ...+.+++ T Consensus 3 ~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~~~~~~----~~~~~~~~ 58 (304) T 3O1I_C 3 GSDEKICAIYPHLKD------------SYWLSVNYGMVSEAEKQG--------VNLRVLEAGGYPNKS----RQEQQLAL 58 (304) T ss_dssp --CCEEEEEESCSCS------------HHHHHHHHHHHHHHHHHT--------CEEEEEECSSTTCHH----HHHHHHHH T ss_pred CCCceEEEEEccCCC------------hHHHHHHHHHHHHHHHcC--------CEEEEEcCCCCCCHH----HHHHHHHH Confidence 467899999987432 245677788888888753 455555444322321 22233443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. ++++++|+...+.. .......+. .++|+|..+...+... ....++.+++.++... T Consensus 59 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~-~~ipvv~~~~~~~~~~-~~~~~~~~~v~~d~~~ 117 (304) T 3O1I_C 59 CTQ-------------------WGANAIILGTVDPHAYEHNLKSWV-GNTPVFATVNQLDLDE-EQSTLLKGEVGVDWYW 117 (304) T ss_dssp HHH-------------------HTCSEEEECCSSTTSSTTTHHHHT-TTSCEEECSSCCCCCT-TTGGGEEEECCCCHHH T ss_pred HHH-------------------hCCCEEEEcCCCHHhHHHHHHHHh-cCCCEEEEecCCCCCh-HHhhcceEEEEcChHH Confidence 332 47888877543322 223334455 6999988765433211 0113567788888877 Q NP_000836.2 202 QAQAMVDIVTAL-----GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 202 ~~~~~~~~l~~~-----~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) .++.+++++.+. +.++++++.. +..++..+.+++++.+++. ++++....... ....+....++++++..+ T Consensus 118 ~~~~~~~~l~~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 194 (304) T 3O1I_C 118 MGYEAGKYLAERHPKGSGKTNIALLLGPRTRGGTKPVTTGFYEAIKNS-DIHIVDSFWAD--NDKELQRNLVQRVIDMGN 194 (304) T ss_dssp HHHHHHHHHHTTSBTTTCCEEEEEECCCC-----CHHHHHHHHTTTTB-TEEEEECCCCC--SCHHHHHHHHHHHHHHSC T ss_pred HHHHHHHHHHHHCCCCCCCeEEEEEeCCCCCCcchHHHHHHHHHHhcC-CcEEeeeeecC--CCHHHHHHHHHHHHHcCC Confidence 788888887554 6678999985 3335667788888888764 35443221111 111233344555542235 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +++|+.. ++ .+..+++++++.|+..++.+++. T Consensus 195 ~~~i~~~-~~-~~~~~~~~~~~~g~~~~~~v~~~ 226 (304) T 3O1I_C 195 IDYIVGS-AV-AIEAAISELRSADKTHDIGLVSV 226 (304) T ss_dssp CSEEEEC-HH-HHHHHHHHHTTTTCGGGSEEBCS T ss_pred CCEEEEc-ch-HHHHHHHHHHHCCCCCCeEEEEE Confidence 6666554 33 56778888887776323444443 No 160 >3O1I_D Sensor protein TorS (E.C.2.7.13.3), Periplasmic; Ligand free, Two component sensor; HET: PE4; 2.8A {Vibrio parahaemolyticus} Probab=97.41 E-value=1.6e-07 Score=95.14 Aligned_cols=216 Identities=7% Similarity=-0.002 Sum_probs=122.7 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||++.|.... ..+..+..+++.++++.+ +++.+...|...++. ...+.+++ T Consensus 3 ~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~~~~~~----~~~~~~~~ 58 (304) T 3O1I_D 3 GSDEKICAIYPHLKD------------SYWLSVNYGMVSEAEKQG--------VNLRVLEAGGYPNKS----RQEQQLAL 58 (304) T ss_dssp --CCEEEEEESCSCS------------HHHHHHHHHHHHHHHTTT--------CEEEEEECSSTTCHH----HHHHHHHH T ss_pred CCCceEEEEEccCCC------------hHHHHHHHHHHHHHHHcC--------CEEEEEcCCCCCCHH----HHHHHHHH Confidence 467899999987432 245677788888888753 455555444322321 22233443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. ++++++|+...+.. .......+. .++|+|..+...+... ....++.+++.++... T Consensus 59 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~-~~ipvv~~~~~~~~~~-~~~~~~~~~v~~d~~~ 117 (304) T 3O1I_D 59 CTQ-------------------WGANAIILGTVDPHAYEHNLKSWV-GNTPVFATVNQLDLDE-EQSTLLKGEVGVDWYW 117 (304) T ss_dssp HHH-------------------HTCSEEEECCSCGGGSTTTTHHHH-TTCCEEECSSCCCCCT-TGGGGEEEECCCCTHH T ss_pred HHH-------------------hCCCEEEEcCCCHHhHHHHHHHHh-cCCCEEEEecCCCCCh-HHhhcceEEEEcChHH Confidence 332 47888877543322 223334455 6999988765433211 0113567788888877 Q NP_000836.2 202 QAQAMVDIVTAL-----GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 202 ~~~~~~~~l~~~-----~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) .++.+++++.+. +.++++++.. +..++..+.+++++.+++. ++++....... ....+....++++++..+ T Consensus 118 ~~~~~~~~l~~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 194 (304) T 3O1I_D 118 MGYEAGKYLAERHPKGSGKTNIALLLGPRTRGGTKPVTTGFYEAIKNS-DIHIVDSFWAD--NDKELQRNLVQRVIDMGN 194 (304) T ss_dssp HHHHHHHHHHTTSCTTSCCEEEEEECCSSSTTTSHHHHHHHHHHHHSS-SEEEEEECCCC--SCHHHHHHHHHHHHHHSC T ss_pred HHHHHHHHHHHHCCCCCCCeEEEEEeCCCCCCcchHHHHHHHHHHhcC-CcEEeeeeecC--CCHHHHHHHHHHHHHcCC Confidence 788888887554 6678999985 3335667788888888764 35443221111 111233344555542235 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +++|+.. ++ .+..+++++++.|+..++.+++. T Consensus 195 ~~~i~~~-~~-~~~~~~~~~~~~g~~~~~~v~~~ 226 (304) T 3O1I_D 195 IDYIVGS-AV-AIEAAISELRSADKTHDIGLVSV 226 (304) T ss_dssp CSEEEEC-HH-HHHHHHHHHHHTTCTTTSEEEES T ss_pred CCEEEEc-ch-HHHHHHHHHHHCCCCCCeEEEEE Confidence 6666554 33 56778888887776323444443 No 161 >3O1J_C Sensor protein TorS (E.C.2.7.13.3), Periplasmic; Isopropanol bound, Two component sensor; 2.95A {Vibrio parahaemolyticus} Probab=97.41 E-value=1.6e-07 Score=95.14 Aligned_cols=216 Identities=7% Similarity=-0.002 Sum_probs=120.7 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||++.|.... ..+..+..+++.++++.+ +++.+...|...++. ...+.+++ T Consensus 3 ~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~~~~~~----~~~~~~~~ 58 (304) T 3O1J_C 3 GSDEKICAIYPHLKD------------SYWLSVNYGMVSEAEKQG--------VNLRVLEAGGYPNKS----RQEQQLAL 58 (304) T ss_dssp --CCEEEEEESCSCS------------HHHHHHHHHHHHHHHHTT--------CEEEEEECSSTTCHH----HHHHHHHH T ss_pred CCCceEEEEEccCCC------------hHHHHHHHHHHHHHHHcC--------CEEEEEcCCCCCCHH----HHHHHHHH Confidence 467899999987432 245677788888888753 455555444322321 22233443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. ++++++|+...+.. .......+. .++|+|..+...+... ....++.+++.++... T Consensus 59 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~-~~ipvv~~~~~~~~~~-~~~~~~~~~v~~d~~~ 117 (304) T 3O1J_C 59 CTQ-------------------WGANAIILGTVDPHAYEHNLKSWV-GNTPVFATVNQLDLDE-EQSTLLKGEVGVDWYW 117 (304) T ss_dssp HHH-------------------HTCSEEEECCSSSSTTSSCSTTTT-TTCCEEECSSCCCCCH-HHHTTEEEEECCCHHH T ss_pred HHH-------------------hCCCEEEEcCCCHHhHHHHHHHHh-cCCCEEEEecCCCCCh-HHhhcceEEEEcChHH Confidence 332 47888877543322 223334455 6999988765433211 0113567788888877 Q NP_000836.2 202 QAQAMVDIVTAL-----GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 202 ~~~~~~~~l~~~-----~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) .++.+++++.+. +.++++++.. +..++..+.+++++.+++. ++++....... ....+....++++++..+ T Consensus 118 ~~~~~~~~l~~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 194 (304) T 3O1J_C 118 MGYEAGKYLAERHPKGSGKTNIALLLGPRTRGGTKPVTTGFYEAIKNS-DIHIVDSFWAD--NDKELQRNLVQRVIDMGN 194 (304) T ss_dssp HHHHHHHHHHHHSCTTSCCEEEEEEEECCC----THHHHHHHHHHSSS-SEEEEEEEECC--SCHHHHHHHHHHHHHTCC T ss_pred HHHHHHHHHHHHCCCCCCCeEEEEEeCCCCCCcchHHHHHHHHHHhcC-CcEEeeeeecC--CCHHHHHHHHHHHHHcCC Confidence 788888887554 6678999985 3335667788888888764 35443221111 111233344555542235 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +++|+.. ++ .+..+++++++.|+..++.+++. T Consensus 195 ~~~i~~~-~~-~~~~~~~~~~~~g~~~~~~v~~~ 226 (304) T 3O1J_C 195 IDYIVGS-AV-AIEAAISELRSADKTHDIGLVSV 226 (304) T ss_dssp CSEEEEC-HH-HHHHHHHHHHHTTCTTTSEEEES T ss_pred CCEEEEc-ch-HHHHHHHHHHHCCCCCCeEEEEE Confidence 6666554 33 56778888887776323444443 No 162 >4YHS_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: MSE, BTB; 1.8A {Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)} Probab=97.41 E-value=1.6e-07 Score=97.66 Aligned_cols=215 Identities=11% Similarity=0.036 Sum_probs=122.9 Template_Neff=10.800 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+.++||++.|..+. .++..+..+++.++++. |+++.+...|+..++ ....+. T Consensus 53 ~~~~~~~~Igvv~~~~~~------------~~~~~~~~g~~~a~~~~--------g~~l~~~~~~~~~~~----~~~~~~ 108 (354) T 4YHS_A 53 EKASKPWKLCVSFPHMKD------------AYWLGVDYGVAEESKRL--------GVKMNLVEAGGYTEL----NKQISQ 108 (354) T ss_dssp SCCSSCCEEEEEESCCCS------------HHHHHHHHHHHHHHHHH--------TCEEEEEECSSTTCH----HHHHHH T ss_pred ccCCCCeEEEEEeCCCCC------------HHHHHHHHHHHHHHHHh--------CCEEEEEecCCCCCH----HHHHHH Confidence 345678999999987542 24567778888888774 345655555432232 122333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAA-ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+.. .+.........+.+.++|+|.++...+. .++.+++.++ T Consensus 109 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d 163 (354) T 4YHS_A 109 IEDCVA-------------------SGTDAVIIGAISADGLNKVIGEIAKKKIPVIDLVNGISS------PDIAAKSLVS 163 (354) T ss_dssp HHHHHH-------------------HCCSEEEECCSSSSTTHHHHHHHHTTTCCEEEESSCCCC------TTCCEEECCC T ss_pred HHHHHH-------------------cCCCEEEEcCCCHHhhHHHHHHHHhcCCCEEEEcCCCCC------hhhceEeecC Confidence 444332 4677776543 3322334455667789999987654321 2445667777 Q NP_000836.2 199 DSYQAQAMVDIVTAL---GWNYVSTLA----SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 199 ~~~~~~~~~~~l~~~---~~~~v~ii~----~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) ....++.+++++.+. +.+++++++ .+..++..+.++|++.+++. ++.+....... .+..+....++++++ T Consensus 164 ~~~~~~~~~~~l~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~g~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~l~ 240 (354) T 4YHS_A 164 FYTMGAETGSYLAKKHPAGTPEVVVGWFPGPAGAGWVEAANKGFMDAVKGS-AIKVLEPKYGD--TGKEVQAKLVEDALQ 240 (354) T ss_dssp HHHHHHHHHHHHHHHSCTTSCCEEEEEECSSTTCHHHHHHHHHHHHHHTTS-SEEECCCCCCC--SCHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHCCCCCCcEEEEEEcCCCCChHHHHHHHHHHHHHcCC-CcEEEccccCC--CCHHHHHHHHHHHHH Confidence 777777888887654 778888863 12334566778888877764 35443221111 111233344555542 Q NP_000836.2 272 T-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 272 ~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) . .++++|+.. +..+..+++++++.|+..++.+++. T Consensus 241 ~~~~~~~i~~~--~~~a~~~~~~l~~~g~~~~v~i~g~ 276 (354) T 4YHS_A 241 AAPNIRYVAGT--AVTAEAAQGLIRERGLKGKVDLLAF 276 (354) T ss_dssp HCTTCCEEEEC--HHHHHHHHHHHHHTTCBTTBEEEES T ss_pred HCCCCCEEEEC--chHHHHHHHHHHHCCCCCCcEEEEE Confidence 1 245555443 3456777888887776323334443 No 163 >3CLK_B Transcription regulator; 11017j, PSI-II, NYSGXRC, dimer, Structural; 2.08A {Lactobacillus plantarum WCFS1} Probab=97.41 E-value=1.6e-07 Score=94.34 Aligned_cols=205 Identities=11% Similarity=0.084 Sum_probs=114.7 Template_Neff=11.800 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++.++||++.|..+. .++.....+++.++++. |+++.+...+. .++ ....+.+ T Consensus 4 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~~~~~~~~~-~~~----~~~~~~~ 58 (290) T 3CLK_B 4 VKKSSNVIAAVVSSVRT------------NFAQQILDGIQEEAHKN--------GYNLIIVYSGS-ADP----EEQKHAL 58 (290) T ss_dssp ------CEEEEEC----------------CHHHHHHHHHHHHHTTT--------TCCEEEEC-----------CHHHHHH T ss_pred ccCCCCEEEEEECCCCC------------hHHHHHHHHHHHHHHHc--------CCeEEEEeCCC-CCH----HHHHHHH Confidence 34568999999987542 25566778888887765 34454443332 221 1222333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .++|++|+...+.. ......+...++|+|..+...+ +.++.+.+++. T Consensus 59 ~~~~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ip~v~~~~~~~--------~~~~~v~~d~~ 110 (290) T 3CLK_B 59 LTAIE-------------------RPVMGILLLSIALT-DDNLQLLQSSDVPYCFLSMGFD--------DDRPFISSDDE 110 (290) T ss_dssp HHHHH-------------------SCCSEEEEESCCCC-HHHHHHHHHTTCCEEEESCCCS--------SSCCEEECCHH T ss_pred HHHHh-------------------CCCCEEEEecccCC-hHHHHHHHhCCCCEEEEccCCC--------CCCCEEeeCcH Confidence 33332 47888887654433 3444566778999998765432 24566777777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ..++.+++++.+.+.++++++..+.. ++..+.+++++.+++. ++.+........+.+..+....++++....++|+| T Consensus 111 ~~~~~~~~~l~~~g~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d~i 189 (290) T 3CLK_B 111 DIGYQATNLLINEGHRQIGIAGIDQYPYTGRKRLAGYKKALKEA-NIAINQEWIKPGDYSYTSGEQAMKAFGKNTDLTGI 189 (290) T ss_dssp HHHHHHHHHHHTTTCCSEEEESCCCSSHHHHHHHHHHHHHHHHT-TCCCCGGGEECCCSSHHHHHHHHHHHCTTCCCSEE T ss_pred HHHHHHHHHHHHCCCCCEEEEcCCCCCccchHHHHHHHHHHHHC-CCCCChhhccCCCCChhhHHHHHHHHhhCCCCCEE Confidence 77888888887668889999985443 5566778888888765 34443211111001112233444444322467888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 190 ~~~~-~~~~~~~~~~l~~~g~~ 210 (290) T 3CLK_B 190 IAAS-DMTAIGILNQASSFGIE 210 (290) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHCCCC Confidence 7664 33466778888877764 No 164 >2RGY_A Transcriptional regulator, LacI family; 11011j, NYSGXRC, Transctiptional regulator, LacI; 2.05A {Burkholderia phymatum} Probab=97.40 E-value=1.6e-07 Score=94.18 Aligned_cols=208 Identities=13% Similarity=0.021 Sum_probs=118.5 Template_Neff=12.000 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..+++++||++.|..+. .++..+..+++.++++. |+++.+...++..+. .+...+.+ T Consensus 4 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~~~~~~~~~~~~~---~~~~~~~~ 60 (290) T 2RGY_A 4 ATQQLGIIGLFVPTFFG------------SYYGTILKQTDLELRAV--------HRHVVVATGCGESTP---REQALEAV 60 (290) T ss_dssp ----CCEEEEECSCSCS------------HHHHHHHHHHHHHHHHT--------TCEEEEECCCSSSCH---HHHHHHHH T ss_pred ccCCCceEEEEecCCCC------------chHHHHHHHHHHHHHHC--------CCeEEEEeCCCCCCh---HHHHHHHH Confidence 44578999999997542 25566777877666653 344544433321111 11222333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +.+.. .++|++|+...+... .....+.+.++|+|..+...+ .++.+++..++. T Consensus 61 ~~~~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~ 113 (290) T 2RGY_A 61 RFLIG-------------------RDCDGVVVISHDLHD-EDLDELHRMHPKMVFLNRAFD-------ALPDASFCPDHR 113 (290) T ss_dssp HHHHH-------------------TTCSEEEECCSSSCH-HHHHHHHHHCSSEEEESSCCT-------TSGGGEECCCHH T ss_pred HHHhh-------------------CCCCEEEEEcCCCCH-HHHHHHHHcCCcEEEECCCCC-------CCCCceeecChH Confidence 33322 478888875544332 444556678999988765432 134566667777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNY--GESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~--~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ..+..+++++.+.+.++++++..+..+ +..+.+++++.+++. ++.+........+.+..+....+++++.. .++++ T Consensus 114 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ 192 (290) T 2RGY_A 114 RGGELAAATLIEHGHRKLAVISGPFTASDNVERLDGFFDELARH-GIARDSVPLIESDFSPEGGYAATCQLLESKAPFTG 192 (290) T ss_dssp HHHHHHHHHHHHTTCCSEEEEESCTTCHHHHHHHHHHHHHHHTT-TCCGGGSCEEECCSSHHHHHHHHHHHHHHTCCCSE T ss_pred HHHHHHHHHHHHCCCCeEEEEeCCCCCccHHHHHHHHHHHHHHC-CCCCCCCcEEEcCCChHHHHHHHHHHHhCCCCCCE Confidence 777788888766688899999865433 556777888877764 34332111111001122334445555421 24788 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 193 i~~~~-~~~a~~~~~~l~~~g~~ 214 (290) T 2RGY_A 193 LFCAN-DTMAVSALARFQQLGIS 214 (290) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 87664 44567788888887764 No 165 >6HB0_A ABC transporter periplasmic-binding protein YtfQ; periplasmic binding protein, SUGAR BINDING; HET: ZN; 1.9A {Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)} Probab=97.39 E-value=1.8e-07 Score=95.75 Aligned_cols=211 Identities=12% Similarity=0.058 Sum_probs=120.2 Template_Neff=11.600 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....+.++||++.|..+. .++.....+++.++++.| +++.+.|+..++. ...+ T Consensus 13 ~~~~~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~l~~~~~~~~~~----~~~~ 66 (322) T 6HB0_A 13 GSAPDGALTLGFAQVGAES------------GWRTANTESIKSAAEEAG----------VNLKFADANGEQE----KQIS 66 (322) T ss_dssp -----CCCEEEEEECC---------------CCSCCCHHHHHHHHHHHT----------CEEEEEECTTCHH----HHHH T ss_pred CCCCCCCeEEEEEeeCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEECCCCCHH----HHHH Confidence 4566789999999997642 255667788888887753 3344555443322 2233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAAS-SVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s-~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. .+++++|....+ .........+...++|+|..+...+.. ...++.+++.+ T Consensus 67 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~---~~~~~~~~v~~ 124 (322) T 6HB0_A 67 AIRSFIQ-------------------QGVDVIAFSPVVRTGWDAVLQETKNAGIPVILTDRAVDTQ---DTDVYKTFIGA 124 (322) T ss_dssp HHHHHHH-------------------TTCSEEEECCSSSSSCHHHHHHHHHTTCCEEEESSCCCCS---SSSSCSEEECC T ss_pred HHHHHHH-------------------cCCCEEEECCCCcccHHHHHHHHHHCCCCEEEECCCCCCC---CCchhceEEec Confidence 3443332 367766653332 222344455667899999877644321 11345677788 Q NP_000836.2 198 PDSYQAQAMVDIVTA-----LGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL 270 (908) Q Consensus 198 ~~~~~~~~~~~~l~~-----~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~ 270 (908) ++...++.+++++.+ .+.++++++.. ++.++..+.++|++.+++.+++++....... .+..+....+++++ T Consensus 125 d~~~~~~~~~~~l~~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~~~~~--~~~~~~~~~~~~~~ 202 (322) T 6HB0_A 125 DFIEEGRRAGQWVADQYASATGPVNIVQLEGTTGADPAIDRKTGFAEGISKNPNLKIVASQTGD--FTRSGGKQVMEAFL 202 (322) T ss_dssp CHHHHHHHHHHHHHHHTTTCSSCEEEEEEECSTTCHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TSHHHHHHHHHHHH T ss_pred ChHHHHHHHHHHHHHHHHhcCCCeEEEEEEcCCCCchHHHHHHHHHHHHhhCCCcEEEEeecCC--CCHHHHHHHHHHHH Confidence 877778888887754 47789999985 3456667788888887764224443221111 11123344555554 Q NP_000836.2 271 E-TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 271 ~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) . ..++++|++.. +..+..+++++++.|+. T Consensus 203 ~~~~~~d~i~~~~-~~~a~~~~~~~~~~g~~ 232 (322) T 6HB0_A 203 KSTPQIDVVFAQN-DDMGLGAMEAIEAAGKK 232 (322) T ss_dssp HHCSCCCEEEESS-HHHHHHHHHHHHHTTCC T ss_pred HHCCCcCEEEECC-HHHHHHHHHHHHHcCCC Confidence 2 13567776654 34556778888877764 No 166 >1SXG_D Glucose-resistance amylase regulator; allosterism phosphoprotein transcription; HET: 171; 2.75A {Bacillus megaterium} SCOP: c.93.1.1 Probab=97.39 E-value=1.8e-07 Score=93.21 Aligned_cols=204 Identities=11% Similarity=0.116 Sum_probs=120.8 Template_Neff=12.200 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++..+..+++.++++.+ +++.+.|+..++ +...+.++ T Consensus 5 ~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 58 (280) T 1SXG_D 5 SKKTTTVGVIIPDISN------------IFYAELARGIEDIATMYK----------YNIILSNSDQNQ----DKELHLLN 58 (280) T ss_dssp -CCCCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHHH T ss_pred CCCCCeEEEEeCCccc------------HHHHHHHHHHHHHHHHcC----------CeEEEeeCCCCH----HHHHHHHH Confidence 4568999999987542 245667778887776642 334445544332 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+. .......+...++|+|..+...+ .++.+++.+++.. T Consensus 59 ~l~~-------------------~~~d~ii~~~~~~-~~~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~~ 111 (280) T 1SXG_D 59 NMLG-------------------KQVDGIIFMSGNV-TEEHVEELKKSPVPVVLAASIES-------TNQIPSVTIDYEQ 111 (280) T ss_dssp HHHH-------------------TCCSEEEECCSCC-CHHHHHHHHHCSSCEEEESCCCT-------TCCSCEEEECHHH T ss_pred HHHc-------------------CCCCEEEEeCCCC-CHHHHHHHHhCCCCEEEeCCCCC-------CCCCCeEEeChHH Confidence 4332 4788888755443 33444556678999998765322 2346677777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) .++.+++++.+.+.++++++..+.. .+..+.++|++.+++. ++.+.....+..+.+..+....+++++.. .++++ T Consensus 112 ~~~~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 190 (280) T 1SXG_D 112 AAFDAVQSLIDSGHKNIAFVSGTLEEPINHAKKVKGYKRALTES-GLPVRDSYIVEGDYTYDSGIEAVEKLLEEDEKPTA 190 (280) T ss_dssp HHHHHHHHHHTTSCSCEEEEESCTTSHCCCCCCHHHHHHHHHHT-TCCCCGGGEEECCSSHHHHHHHHHHHTTSSSCCSE T ss_pred HHHHHHHHHHHCCCCeEEEEeCCCCCcccHHHHHHHHHHHHHHc-CCCCCHHHeeecCCChhhHHHHHHHHHHcCCCCCE Confidence 7888888876667889999985433 4556778888887765 34433221111001122334445555421 24677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 191 v~~~~-~~~~~~~~~~l~~~g~~ 212 (280) T 1SXG_D 191 IFVGT-DEMALGVIHGAQDRGLN 212 (280) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-hHHHHHHHHHHHHCCCC Confidence 76654 34566777888877763 No 167 >2NZV_G Catabolite control protein, Phosphocarrier protein; CCpA, HPrser46-p, CCR, fructose-bis-phosphate, adjunct; HET: SEP, SO4, FBP; 3.0A {Bacillus megaterium} SCOP: c.93.1.1 Probab=97.39 E-value=1.8e-07 Score=93.21 Aligned_cols=204 Identities=11% Similarity=0.116 Sum_probs=120.8 Template_Neff=12.200 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++..+..+++.++++.+ +++.+.|+..++ +...+.++ T Consensus 5 ~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 58 (280) T 2NZV_G 5 SKKTTTVGVIIPDISN------------IFYAELARGIEDIATMYK----------YNIILSNSDQNQ----DKELHLLN 58 (280) T ss_dssp -CCCSEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHHH T ss_pred CCCCCeEEEEeCCccc------------HHHHHHHHHHHHHHHHcC----------CeEEEeeCCCCH----HHHHHHHH Confidence 4568999999987542 245667778887776642 334445544332 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+. .......+...++|+|..+...+ .++.+++.+++.. T Consensus 59 ~l~~-------------------~~~d~ii~~~~~~-~~~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~~ 111 (280) T 2NZV_G 59 NMLG-------------------KQVDGIIFMSGNV-TEEHVEELKKSPVPVVLAASIES-------TNQIPSVTIDYEQ 111 (280) T ss_dssp HHHH-------------------TCCSCEEECCSCC-CHHHHHHTTSCSSCEEEESCCCT-------TCCSCEEEECHHH T ss_pred HHHc-------------------CCCCEEEEeCCCC-CHHHHHHHHhCCCCEEEeCCCCC-------CCCCCeEEeChHH Confidence 4332 4788888755443 33444556678999998765322 2346677777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) .++.+++++.+.+.++++++..+.. .+..+.++|++.+++. ++.+.....+..+.+..+....+++++.. .++++ T Consensus 112 ~~~~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 190 (280) T 2NZV_G 112 AAFDAVQSLIDSGHKNIAFVSGTLEEPINHAKKVKGYKRALTES-GLPVRDSYIVEGDYTYDSGIEAVEKLLEEDEKPTA 190 (280) T ss_dssp HHHHHHHHHHHHHCSCEEEECSCTTSHHCCCCCCHHHHHHHHTT-CCCCCTTSEECCCSSHHHHHHHHHHHHTSSSCCSE T ss_pred HHHHHHHHHHHCCCCeEEEEeCCCCCcccHHHHHHHHHHHHHHc-CCCCCHHHeeecCCChhhHHHHHHHHHHcCCCCCE Confidence 7888888876667889999985433 4556778888887765 34433221111001122334445555421 24677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 191 v~~~~-~~~~~~~~~~l~~~g~~ 212 (280) T 2NZV_G 191 IFVGT-DEMALGVIHGAQDRGLN 212 (280) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-hHHHHHHHHHHHHCCCC Confidence 76654 34566777888877763 No 168 >4RS3_A ABC transporter, carbohydrate uptake transporter-2; SUGAR TRANSPORTER, ABC-TYPE, ENZYME FUNCTION; HET: XYL, MSE, IMD, ACT, ZN, CL; 1.4A {Mycobacterium smegmatis str. MC2 155} Probab=97.37 E-value=1.9e-07 Score=95.69 Aligned_cols=213 Identities=13% Similarity=0.075 Sum_probs=120.1 Template_Neff=11.500 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+.++||++.|..+. ++.....+++.++++.+ +++.+.|+..++. ...+. T Consensus 7 ~~~~~~~~Ig~v~~~~~~-------------~~~~~~~g~~~~~~~~~----------~~l~~~~~~~~~~----~~~~~ 59 (327) T 4RS3_A 7 AANSDTKRIGVTVYDMSS-------------FITEGKEGMDTYAKANN----------IELVWNSANNDVS----TQASQ 59 (327) T ss_dssp -----CEEEEEEESCCCH-------------HHHHHHHHHHHHHHHTT----------EEEEEEECTTCHH----HHHHH T ss_pred cccCCCcEEEEEECCccH-------------HHHHHHHHHHHHHHHCC----------cEEEEecCCCCHH----HHHHH Confidence 345678999999987532 44566777777776632 3445555543322 22333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+... ......+...++|+|.++...+. .++++++.++ T Consensus 60 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d 114 (327) T 4RS3_A 60 VDSLIN-------------------QGVDAIIVVPVQADSLGPQVASAKSKGIPLLAVNAALET------PDLAGNVQPD 114 (327) T ss_dssp HHHHHH-------------------HTCSEEEEECSCSSCCHHHHHHHHHTTCCEEEESSCCCC------TTCSEEEEEC T ss_pred HHHHHh-------------------CCCCEEEEecCCccccHHHHHHHHHCCCCEEEEcCCCCC------CCcceEecCC Confidence 343332 467877765443322 23344556679999987654321 2345677777 Q NP_000836.2 199 DSYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-- 272 (908) Q Consensus 199 ~~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-- 272 (908) +...+..+++++.+. +.++++++.. ++.++..+.++|++.+++.+++++....... .+..+....++++++. T Consensus 115 ~~~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~ 192 (327) T 4RS3_A 115 DVAAGAQEMQMMADRLGGKGNIVILQGPLGGSGEINRGKGIDQVLAKYPDIKVLAKDTAN--WKRDEAVNKMKNWISSFG 192 (327) T ss_dssp HHHHHHHHHHHHHHHHTTCEEEEEEECSTTSHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHHG T ss_pred hHHHHHHHHHHHHHHhCCCcEEEEEECCCCChhHHHHHHHHHHHHHhCCCcEEEEeecCC--CCHHHHHHHHHHHHHHhc Confidence 777777888887654 7789999885 3445666777888777664223332211111 1122344445555421 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) .++++|++.. +..+..+++++++.|+. ++.+++. T Consensus 193 ~~~~~i~~~~-~~~a~~~~~~l~~~g~~-~i~i~g~ 226 (327) T 4RS3_A 193 PQIDGVVAQN-DDMGLGALQALKEAGRT-GVPIVGI 226 (327) T ss_dssp GGCCEEEESS-HHHHHHHHHHHHHTTCC-CCCEECS T ss_pred CCCCEEEECC-hHHHHHHHHHHHHcCCC-CCCEEEe Confidence 2377776664 44566788888887763 2344443 No 169 >5OCP_A Periplasmic binding protein/LacI transcriptional regulator; ABC transporter, periplasmic, binding protein; HET: FUB, GOL, AHR; 1.7A {Shewanella sp. ANA-3} Probab=97.36 E-value=2e-07 Score=94.25 Aligned_cols=203 Identities=14% Similarity=0.084 Sum_probs=118.2 Template_Neff=11.600 Q NP_000836.2 47 ILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEK 126 (908) Q Consensus 47 ~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~~~ 126 (908) +||+++|.... .++..+..+++.++++.+ +++.+.|+..++. ...+.+++++. T Consensus 2 ~Igv~~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~l~~~~~~~~~~----~~~~~~~~l~~- 54 (302) T 5OCP_A 2 TVGFSQVGSES------------GWRTSFSEAVKAEAKQRG----------IDLKFADAQQKQE----NQIKAVRSFIA- 54 (302) T ss_dssp EEEEEECCCSS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCHH----HHHHHHHHHHH- T ss_pred eEEEecCCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEecCCCCHH----HHHHHHHHHHH- Confidence 67888764322 255677788888887642 3445555544322 22333443332 Q NP_000836.2 127 DASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQA 205 (908) Q Consensus 127 ~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~ 205 (908) ++++++|+...+... ......+...++|+|..+...+.. ...++++++.+++...++. T Consensus 55 ------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~---~~~~~~~~v~~d~~~~~~~ 113 (302) T 5OCP_A 55 ------------------QGVDAIIIAPVVETGWKPVLKEAKRAKIPVVIVDRNIKVD---DDSLFLTRIASDFSEEGRK 113 (302) T ss_dssp ------------------TTCSEEEECCSSSSSCHHHHHHHHHTTCCEEEESSCCCCS---CGGGCSEEEECCHHHHHHH T ss_pred ------------------cCCCEEEEcCCCcCChHHHHHHHHHCCCCEEEEcCCCCCC---ccccceEEEcCCchHHHHH Confidence 467877765443332 244556677899999887654321 1235677888888777888 Q NP_000836.2 206 MVDIVTAL--GWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET---PNARAV 278 (908) Q Consensus 206 ~~~~l~~~--~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~---~~~~vi 278 (908) +++++.+. +.++++++..+.. ++..+.++|++.+++.+...+....... .+..+....++++++. .++|+| T Consensus 114 ~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~~d~i 191 (302) T 5OCP_A 114 IGQWLMDKTQGNCDIAELQGTVGATAAIDRAAGFNQVIANYPNAKIVRSQTGE--FTRAKGKEVMEGFLKAQNGQPLCAV 191 (302) T ss_dssp HHHHHHHHTTTCEEEEEEECCTTCHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHHTTCCCCEE T ss_pred HHHHHHHHcCCCeeEEEEEcCCCCHHHHHHHHHHHHHHHhCCCcEEEEeeeCC--CCHHHHHHHHHHHHHHcCCCCccEE Confidence 88887654 7889999985433 5667778888877764222222111111 1112333444554421 357787 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 192 ~~~~-~~~a~~~~~~l~~~g~~ 212 (302) T 5OCP_A 192 WSHN-DEMALGAVQAIKEAGLK 212 (302) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHCCCC Confidence 7664 44566788888877764 No 170 >3BIL_A Probable LacI-family transcriptional regulator; STRUCTURAL GENOMICS, UNKNOWN FUNCTION, PSI-2; 2.5A {Corynebacterium glutamicum ATCC 13032} Probab=97.36 E-value=2.1e-07 Score=96.38 Aligned_cols=202 Identities=11% Similarity=0.033 Sum_probs=116.9 Template_Neff=11.400 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++.....+++.++++.+ +++.+.|+..++ +...+.++ T Consensus 63 ~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 116 (348) T 3BIL_A 63 SSRSNTIGVIVPSLIN------------HYFAAMVTEIQSTASKAG----------LATIITNSNEDA----TTMSGSLE 116 (348) T ss_dssp -----CEEEEESCSSS------------HHHHHHHHHHHHHHHHTT----------CCEEEEECTTCH----HHHHHHHH T ss_pred cCCCCEEEEEEcCCCC------------hHHHHHHHHHHHHHHHCC----------CEEEEEcCCCCh----hhhhHHHH Confidence 4567899999987542 255667778887777642 334455544332 22233444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. +++|++|+...+. .......+...++|+|..+...+. .++++.+..+... T Consensus 117 ~l~~-------------------~~~d~ii~~~~~~-~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~~~~~ 170 (348) T 3BIL_A 117 FLTS-------------------HGVDGIICVPNEE-CANQLEDLQKQGMPVVLVDRELPG------DSTIPTATSNPQP 170 (348) T ss_dssp HHHH-------------------TTCSCEEECCCGG-GHHHHHHHHHC-CCEEEESSCCSC------C-CCCEEEEECHH T ss_pred HHHH-------------------cCCCEEEECCccc-cHHHHHHHHHcCCCEEEEcCCCCC------CCCCCEEEeCcHH Confidence 4332 4788888755443 334445566789999987764431 2345666666666 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) .+..+++++.+.+.++++++..+. .++..+.++|++.+++. ++.+....... .+..+....+++++. .++|+|+ T Consensus 171 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~d~i~ 246 (348) T 3BIL_A 171 GIAAAVELLAHNNALPIGYLSGPMDTSTGRERLEDFKAACANS-KIGEQLVFLGG--YEQSVGFEGATKLLD-QGAKTLF 246 (348) T ss_dssp HHHHHHHHHHHTTCCSEEEECCCTTSHHHHHHHHHHHHHHHHT-TCCCCEEECCC--SSHHHHHHHHHHHHH-TTCSEEE T ss_pred HHHHHHHHHHhCCCCcEEEEeCCCCChhHHHHHHHHHHHHHhC-CCCcceEEecC--CChHhHHHHHHHHHh-cCCCEEE Confidence 677777777666788999998543 35667788888888764 34332211111 112233445556653 4688877 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~ 300 (908) +.. +..+..+++++++.|.. T Consensus 247 ~~~-d~~a~~~~~~l~~~g~~ 266 (348) T 3BIL_A 247 AGD-SMMTIGVIEACHKAGLV 266 (348) T ss_dssp ESS-HHHHHHHHHHHHHTTCC T ss_pred ECC-HHHHHHHHHHHHHCCCC Confidence 663 44566778888877763 No 171 >3O74_A Fructose transport system repressor FruR; Dual transcriptional regulator, DNA, Transcription; HET: MSE, GOL; 2.0A {Pseudomonas putida} Probab=97.35 E-value=2.3e-07 Score=91.89 Aligned_cols=200 Identities=8% Similarity=0.042 Sum_probs=117.4 Template_Neff=12.400 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++.+ ++ +.+.+...+.. ...+..+.+. T Consensus 2 ~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~--~~~~~~~~~~~----~~~~~~~~~~ 55 (272) T 3O74_A 2 TRTLGFILPDLEN------------PSYARIAKQLEQGARARG--------YQ--LLIASSDDQPD----SERQLQQLFR 55 (272) T ss_dssp CCEEEEEESCTTC------------HHHHHHHHHHHHHHHHTT--------CE--EEEEECTTCHH----HHHHHHHHHH T ss_pred CceEEEEeCCCCC------------hHHHHHHHHHHHHHHHcC--------cE--EEEEeCCCChh----HHHHHHHHHH Confidence 5789999987542 255677788888877652 33 33334322211 1112222221 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . ++++++|+...+.........+...++|+|..+...+. +.++.+..++...+. T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~-------~~~~~v~~d~~~~~~ 109 (272) T 3O74_A 56 A-------------------RRCDALFVASCLPPEDDSYRELQDKGLPVIAIDRRLDP-------AHFCSVISDDRDASR 109 (272) T ss_dssp H-------------------TTCSEEEECCCCCSSCCHHHHHHHTTCCEEEESSCCCT-------TTCEEEEECHHHHHH T ss_pred H-------------------cCCCEEEEecCCCCchHHHHHHHHCCCCEEEECCCCCC-------CCCcEEEeCcHHHHH Confidence 1 47888887654433334455667789999987764331 345667777777777 Q NP_000836.2 205 AMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET--PNARAVIM 280 (908) Q Consensus 205 ~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~--~~~~viv~ 280 (908) .+++++.+.+.++++++..+.. ++..+.++|++.+++. ++.+....... .+..+....++++++. .++|++++ T Consensus 110 ~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~d~v~~ 186 (272) T 3O74_A 110 QLAASLLSSAPRSIALIGARPELSVSQARAGGFDEALQGY-TGEVRRYQGEA--FSRECGQRLMQQLIDDLGGLPDALVT 186 (272) T ss_dssp HHHHHHHTTCCSEEEEEEECTTSHHHHHHHHHHHHHTTTC-CSEEEEEEESS--SSHHHHHHHHHHHHHHHTSCCSEEEE T ss_pred HHHHHHHHhCCCEEEEEEcCCCChHHHHHHHHHHHHHHhc-CCeeeEEeccc--CCHHHHHHHHHHHHHHhCCCCCEEEE Confidence 8888876668889999985433 5667788888888765 34433211111 1112334445555421 35778776 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~ 300 (908) .. +..+..+++++++.|+. T Consensus 187 ~~-~~~a~~~~~~l~~~g~~ 205 (272) T 3O74_A 187 TS-YVLLQGVFDTLQARPVD 205 (272) T ss_dssp SS-HHHHHHHHHHHHTSCGG T ss_pred cC-HHHHHHHHHHHHhCCCC Confidence 64 33466777788777764 No 172 >3O74_B Fructose transport system repressor FruR; Dual transcriptional regulator, DNA, Transcription; HET: GOL; 2.0A {Pseudomonas putida} Probab=97.35 E-value=2.3e-07 Score=91.89 Aligned_cols=200 Identities=8% Similarity=0.042 Sum_probs=117.4 Template_Neff=12.400 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++.+ ++ +.+.+...+.. ...+..+.+. T Consensus 2 ~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~--~~~~~~~~~~~----~~~~~~~~~~ 55 (272) T 3O74_B 2 TRTLGFILPDLEN------------PSYARIAKQLEQGARARG--------YQ--LLIASSDDQPD----SERQLQQLFR 55 (272) T ss_dssp CSEEEEEESCTTC------------HHHHHHHHHHHHHHHHTT--------CE--EEEEECTTCHH----HHHHHHHHHH T ss_pred CceEEEEeCCCCC------------hHHHHHHHHHHHHHHHcC--------cE--EEEEeCCCChh----HHHHHHHHHH Confidence 5789999987542 255677788888877652 33 33334322211 1112222221 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . ++++++|+...+.........+...++|+|..+...+. +.++.+..++...+. T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~-------~~~~~v~~d~~~~~~ 109 (272) T 3O74_B 56 A-------------------RRCDALFVASCLPPEDDSYRELQDKGLPVIAIDRRLDP-------AHFCSVISDDRDASR 109 (272) T ss_dssp H-------------------TTCSEEEECCCSCTTCCHHHHHHHTTCCEEEESSCCCT-------TTCEEEEECHHHHHH T ss_pred H-------------------cCCCEEEEecCCCCchHHHHHHHHCCCCEEEECCCCCC-------CCCcEEEeCcHHHHH Confidence 1 47888887654433334455667789999987764331 345667777777777 Q NP_000836.2 205 AMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET--PNARAVIM 280 (908) Q Consensus 205 ~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~--~~~~viv~ 280 (908) .+++++.+.+.++++++..+.. ++..+.++|++.+++. ++.+....... .+..+....++++++. .++|++++ T Consensus 110 ~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~d~v~~ 186 (272) T 3O74_B 110 QLAASLLSSAPRSIALIGARPELSVSQARAGGFDEALQGY-TGEVRRYQGEA--FSRECGQRLMQQLIDDLGGLPDALVT 186 (272) T ss_dssp HHHHHHHTTCCSEEEEEEECTTSHHHHHHHHHHHHTTTTC-CSEEEEEEESS--SSHHHHHHHHHHHHHHHTSCCSEEEE T ss_pred HHHHHHHHhCCCEEEEEEcCCCChHHHHHHHHHHHHHHhc-CCeeeEEeccc--CCHHHHHHHHHHHHHHhCCCCCEEEE Confidence 8888876668889999985433 5667788888888765 34433211111 1112334445555421 35778776 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~ 300 (908) .. +..+..+++++++.|+. T Consensus 187 ~~-~~~a~~~~~~l~~~g~~ 205 (272) T 3O74_B 187 TS-YVLLQGVFDTLQARPVD 205 (272) T ss_dssp SS-HHHHHHHHHHHHHSCTT T ss_pred cC-HHHHHHHHHHHHhCCCC Confidence 64 33466777788777764 No 173 >4Z0N_A Periplasmic Solute Binding Protein; Periplasmic solute binding Protein, ENZYME; HET: GAL, SO4, EDO, MSE; 1.26A {Streptobacillus moniliformis} Probab=97.34 E-value=2.3e-07 Score=95.62 Aligned_cols=222 Identities=13% Similarity=0.038 Sum_probs=123.0 Template_Neff=11.400 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+.++||++.|..+. .++..+..+++.++++. |+++++...|+..++. ...+. T Consensus 26 ~~~~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~v~~~~~d~~~~~~----~~~~~ 81 (337) T 4Z0N_A 26 KKDTSKITLGVTYYKFDD------------NFLAGMRNDMIQIAKEK--------YPNIELLNNDSQNSQS----ILNDQ 81 (337) T ss_dssp -----CEEEEEEESCTTC------------HHHHHHHHHHHHHHHHH--------CTTEEEEEEECTTCHH----HHHHH T ss_pred CCCCCCeEEEEEEccCCC------------HHHHHHHHHHHHHHHHH--------CCCeEEEeCCCCCCHH----HHHHH Confidence 345568999999986542 25567778888887775 3445666555443322 23333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+... ......+...++|+|..+...+..... ..++++++.++ T Consensus 82 i~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~~-~~~~~~~v~~d 141 (337) T 4Z0N_A 82 IEVLIN-------------------KGVNVLVINLVDPTAGQSVIDKAKAANIPIILFNKDPGVDALN-SYDKAWYVGTT 141 (337) T ss_dssp HHHHHH-------------------TTCSEEEECCSSTTCHHHHHHHHHHHTCCEEEESSCCCHHHHT-TCTTEEEEECC T ss_pred HHHHHH-------------------cCCCEEEEecCCccchHHHHHHHHHCCCCEEEEccCCCCcccc-ccccceEEecC Confidence 444332 478887765433322 244556677899999887654321110 13456677777 Q NP_000836.2 199 DSYQAQAMVDIVTA------------LGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEK 264 (908) Q Consensus 199 ~~~~~~~~~~~l~~------------~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~ 264 (908) ....++.+++++.+ .+.++++++.. ++.+...+.+++++.+++. ++.+..........+..+... T Consensus 142 ~~~~~~~~~~~l~~~~~~~~~~~~~~~g~~~v~~l~~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~ 220 (337) T 4Z0N_A 142 PKDSGILQGQVIEKAWLANPAYDLNGDGVIQYVMLFGEPGQPDAEARTKYSIEYLNEK-GIKTEELHKDIANWDAAQAKD 220 (337) T ss_dssp HHHHHHHHHHHHHHHHHHCGGGCTTCSSSEEEEEEECCTTCHHHHHHHHHHHHHHHHT-TCCEEEEEEEECTTCHHHHHH T ss_pred chHHHHHHHHHHHHHHhcCCccccCCCCeeEEEEEECCCCCcCHHHHHHHHHHHHHhc-CCCceeecccccCCCHHHHHH Confidence 77777777776643 35678998875 3455667778888887764 343321100100011123344 Q NP_000836.2 265 IIKRLLET---PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSD 309 (908) Q Consensus 265 ~~~~l~~~---~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~ 309 (908) .++++++. .++++|+... +..+..+++++++.|. ++.+++.+ T Consensus 221 ~~~~~l~~~~~~~~~~i~~~~-~~~a~~~~~~~~~~g~--~v~vi~~d 265 (337) T 4Z0N_A 221 KMDAWLSGPNANKIEVVIANN-DGMALGAVESIKAVKK--ELPVFGVD 265 (337) T ss_dssp HHHHHHHSTTGGGCCEEEESS-HHHHHHHHHHHHHTTC--CCCEECSB T ss_pred HHHHHHcCCCCCCccEEEECC-hHHHHHHHHHHHHcCC--CCCEEEec Confidence 55555431 2356666553 4455667777777663 34444443 No 174 >4PE6_B solute binding protein; Structural Genomics, PSI-Biology, Midwest Center; HET: MSE, LTH; 1.86A {Thermobispora bispora} Probab=97.34 E-value=2.3e-07 Score=95.76 Aligned_cols=210 Identities=10% Similarity=-0.060 Sum_probs=116.5 Template_Neff=10.900 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++.++||++.|.... .++.....+++.++++.|..++. +++.+...|+..++. ...+. T Consensus 13 ~~~~~~~~Igvv~~~~~~------------~~~~~~~~g~~~a~~~~~~~gg~---~~~~~~~~d~~~~~~----~~~~~ 73 (341) T 4PE6_B 13 QAEGDKPFIALSNGFIGN------------GWRQTMIAKFEEAAKQAQADGLI---GKYKVVNAPGNNSAT----EQVAQ 73 (341) T ss_dssp -----CCEEEEEESCCSS------------HHHHHHHHHHHHHHHHHHHTTSC---SEEEEEECCTTTCHH----HHHHH T ss_pred HHhCCCCEEEEEccccCC------------HHHHHHHHHHHHHHHHhcccCCc---ceEEEEeCCCCCCHH----HHHHH Confidence 455678999999986322 35677889999999998865432 345555555443322 23333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAA-ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. .+++++|+.. .+.........+...++|+|..+...+. ++.+....+ T Consensus 74 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-------~~~~~~~~~ 127 (341) T 4PE6_B 74 IKSLLL-------------------QKPDALLINPASPTALQPVIQQACDAGVKVVVFDSAIDA-------PCAYILQNS 127 (341) T ss_dssp HHHHHT-------------------TCCSEEEEECSSSSTTHHHHHHHHHTTCEEEEESSCCCC-------TTSEEEEEC T ss_pred HHHHHh-------------------cCCCEEEECCCChhhhHHHHHHHHHCCCEEEEeCCCCCC-------CCcEEeeCC Confidence 444332 4778777643 3322234445566789999987764331 233444444 Q NP_000836.2 199 DSYQAQAMVDIVTALG--WNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-P 273 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~--~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~ 273 (908) ....++.+++++.+.+ .++++++.. ++.++..+.++|++.+++..++++....... .+..+....++++++. . T Consensus 128 ~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~ 205 (341) T 4PE6_B 128 FVDWATYAAKPVLESIGGKGNVIVVRGVVGSQPEAEMYETTKKILAEYPQVKTVATVTGM--CDGATAQKAVLGVLPSVS 205 (341) T ss_dssp HHHHHHHHHHHHHHHTTTCEEEEEEECSTTSHHHHHHHHHHHHHHHTCTTEEEEEEEECT--TCHHHHHHHHHHHGGGSC T ss_pred HHHHHHHHHHHHHHHhCCCeeEEEEecCCCChHHHHHHHHHHHHHHhCCCceEEEEEeCC--CCHHHHHHHHHHhHhhCC Confidence 4455667777765443 678998885 3455667788888887753124443221111 1122344455555431 2 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) ++++|++.. + . ..+++++++.|. T Consensus 206 ~~~~i~~~~-d-~-~~~~~al~~~g~ 228 (341) T 4PE6_B 206 TVDAVIGCG-D-G-YGVAQAFATAGK 228 (341) T ss_dssp CCCEEECSS-C-H-HHHHHHHHHHTC T ss_pred CCCEEEEcC-c-H-HHHHHHHHHCCC Confidence 355555543 2 2 567777777765 No 175 >2X7X_A SENSOR PROTEIN (E.C.2.7.13.3); TRANSFERASE, SENSOR HISTIDINE KINASE; HET: PO4, FRU; 2.64A {BACTEROIDES THETAIOTAOMICRON} Probab=97.34 E-value=2.4e-07 Score=94.96 Aligned_cols=213 Identities=11% Similarity=0.088 Sum_probs=118.4 Template_Neff=11.000 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .+++++||++.|.+. .++.....+++.++.+.+ | +++.+.|+..++. ...+.++ T Consensus 3 ~~~~~~Ig~v~~~~~-------------~~~~~~~~g~~~~~~~~~-------g--i~l~~~~~~~~~~----~~~~~~~ 56 (325) T 2X7X_A 3 DTPHFRIGVAQCSDD-------------SWRHKMNDEILREAMFYN-------G--VSVEIRSAGDDNS----KQAEDVH 56 (325) T ss_dssp ---CCEEEEEESCCS-------------HHHHHHHHHHHHHHTTSS-------S--CEEEEEECTTCHH----HHHHHHH T ss_pred CCCCeEEEEEECCCC-------------HHHHHHHHHHHHHHHHhC-------C--eEEEEEECCCCHH----HHHHHHH Confidence 356789999998732 244455666665443321 2 3445555543322 2223344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. ++++++|+...+... ......+...++|+|..+...+. .++++++.+++. T Consensus 57 ~l~~-------------------~~vd~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 111 (325) T 2X7X_A 57 YFMD-------------------EGVDLLIISANEAAPMTPIVEEAYQKGIPVILVDRKILS------DKYTAYIGADNY 111 (325) T ss_dssp HHHH-------------------TTCSEEEECCSSHHHHHHHHHHHHHTTCCEEEESSCCSS------SCSSEEEEECHH T ss_pred HHHH-------------------cCCCEEEEcCCCCCCcHHHHHHHHHCCCCEEEECCCCCC------CCccEEEEcCHH Confidence 3332 478887765444332 23445566789999987654321 245677888877 Q NP_000836.2 201 YQAQAMVDIVTA--LGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNA 275 (908) Q Consensus 201 ~~~~~~~~~l~~--~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~ 275 (908) ..++.+++++.+ .+.++++++.... .++..+.+++++.+++.+++++....... .+..+....+++++. ..++ T Consensus 112 ~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~ 189 (325) T 2X7X_A 112 EIGRSVGNYIASSLKGKGNIVELTGLSGSTPAMERHQGFMAAISKFPDIKLIDKADAA--WERGPAEIEMDSMLRRHPKI 189 (325) T ss_dssp HHHHHHHHHHHHHTTTEEEEEEEESCTTSHHHHHHHHHHHHHHHTCTEEEEEEEEECT--TSHHHHHHHHHHHHHHCSCC T ss_pred HHHHHHHHHHHHHcCCCeEEEEEEcCCCChHHHHHHHHHHHHHhcCCCcEEEEEeeCC--CCccHHHHHHHHHHHhCCCC Confidence 778888888765 5778999998533 35566777888777654223332211111 111233344455542 1256 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|++.. +..+..+++++++.|+..++.+++. T Consensus 190 ~~i~~~~-~~~a~~~~~al~~~g~~~~v~ii~~ 221 (325) T 2X7X_A 190 DAVYAHN-DRIAPGAYQAAKMAGREKEMIFVGI 221 (325) T ss_dssp CEEEESS-TTHHHHHHHHHHHTTCTTSSEEEEE T ss_pred CEEEECC-hhHHHHHHHHHHHcCCCCCCEEEEE Confidence 7776654 3456677788887776323444443 No 176 >2X7X_B SENSOR PROTEIN (E.C.2.7.13.3); TRANSFERASE, SENSOR HISTIDINE KINASE; HET: FRU, PO4; 2.64A {BACTEROIDES THETAIOTAOMICRON} Probab=97.34 E-value=2.4e-07 Score=94.96 Aligned_cols=213 Identities=11% Similarity=0.088 Sum_probs=118.4 Template_Neff=11.000 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .+++++||++.|.+. .++.....+++.++.+.+ | +++.+.|+..++. ...+.++ T Consensus 3 ~~~~~~Ig~v~~~~~-------------~~~~~~~~g~~~~~~~~~-------g--i~l~~~~~~~~~~----~~~~~~~ 56 (325) T 2X7X_B 3 DTPHFRIGVAQCSDD-------------SWRHKMNDEILREAMFYN-------G--VSVEIRSAGDDNS----KQAEDVH 56 (325) T ss_dssp ---CEEEEEEESCCS-------------HHHHHHHHHHHHHHTTST-------T--EEEEEEECTTCHH----HHHHHHH T ss_pred CCCCeEEEEEECCCC-------------HHHHHHHHHHHHHHHHhC-------C--eEEEEEECCCCHH----HHHHHHH Confidence 356789999998732 244455666665443321 2 3445555543322 2223344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. ++++++|+...+... ......+...++|+|..+...+. .++++++.+++. T Consensus 57 ~l~~-------------------~~vd~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 111 (325) T 2X7X_B 57 YFMD-------------------EGVDLLIISANEAAPMTPIVEEAYQKGIPVILVDRKILS------DKYTAYIGADNY 111 (325) T ss_dssp HHHH-------------------TTCSEEEECCSSHHHHHHHHHHHHHTTCCEEEESSCCSS------SCSSEEEEECHH T ss_pred HHHH-------------------cCCCEEEEcCCCCCCcHHHHHHHHHCCCCEEEECCCCCC------CCccEEEEcCHH Confidence 3332 478887765444332 23445566789999987654321 245677888877 Q NP_000836.2 201 YQAQAMVDIVTA--LGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNA 275 (908) Q Consensus 201 ~~~~~~~~~l~~--~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~ 275 (908) ..++.+++++.+ .+.++++++.... .++..+.+++++.+++.+++++....... .+..+....+++++. ..++ T Consensus 112 ~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~ 189 (325) T 2X7X_B 112 EIGRSVGNYIASSLKGKGNIVELTGLSGSTPAMERHQGFMAAISKFPDIKLIDKADAA--WERGPAEIEMDSMLRRHPKI 189 (325) T ss_dssp HHHHHHHHHHHHHTTTCEEEEEEESCTTSHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TSHHHHHHHHHHHHHHCSCC T ss_pred HHHHHHHHHHHHHcCCCeEEEEEEcCCCChHHHHHHHHHHHHHhcCCCcEEEEEeeCC--CCccHHHHHHHHHHHhCCCC Confidence 778888888765 5778999998533 35566777888777654223332211111 111233344455542 1256 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|++.. +..+..+++++++.|+..++.+++. T Consensus 190 ~~i~~~~-~~~a~~~~~al~~~g~~~~v~ii~~ 221 (325) T 2X7X_B 190 DAVYAHN-DRIAPGAYQAAKMAGREKEMIFVGI 221 (325) T ss_dssp CEEEESS-TTHHHHHHHHHHHTTCGGGSEEEEE T ss_pred CEEEECC-hhHHHHHHHHHHHcCCCCCCEEEEE Confidence 7776654 3456677788887776323444443 No 177 >4RXM_A Possible sugar ABC superfamily ATP; TRANSPORTER, ABC-TYPE, ENZYME FUNCTION INITIATIVE; HET: BGC, INS; 1.75A {Mannheimia haemolytica} Probab=97.33 E-value=2.4e-07 Score=92.94 Aligned_cols=205 Identities=12% Similarity=0.043 Sum_probs=117.4 Template_Neff=12.100 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||++.|..+. .++.....+++.++++.+ +++.+.|...++. ...+.+++ T Consensus 2 ~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~a~~~~~----------~~~~~~~~~~~~~----~~~~~~~~ 55 (292) T 4RXM_A 2 MKDELVVFSLPNLSS------------PFEVQLQKVAVETSKKLE----------IKLQVLDGQSSST----KQASDLEN 55 (292) T ss_dssp CCCCEEEEEESCSSS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCHH----HHHHHHHH T ss_pred CcccEEEEecCCCCC------------HHHHHHHHHHHHHHHHcC----------CEEEEEcCCCCHH----HHHHHHHH Confidence 357899999997542 255677788888877642 3445555543322 22233343 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. ++++++|+...+... ......+...++|+|..+...+. .++++++.+++.. T Consensus 56 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~d~~~ 110 (292) T 4RXM_A 56 AIT-------------------RGAKGIIISPNDVNAISGAVEEIIKEKIPAATLDRKVES------SKPVPHFGANNYT 110 (292) T ss_dssp HHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCCC------SSCCCEEEECHHH T ss_pred HHh-------------------cCCCEEEEecCCHhhHHHHHHHHHHCCCCEEEeCCCCCC------CCCccEEecCchH Confidence 332 477877764433322 24445566789999987764321 2356677777777 Q NP_000836.2 202 QAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE--TPNA 275 (908) Q Consensus 202 ~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~--~~~~ 275 (908) .++.+++++.+. +.++++++.. +..++..+.+++++.+++. +..+........+.+..+....+.++++ ..++ T Consensus 111 ~~~~~~~~l~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 189 (292) T 4RXM_A 111 GGQEVAKAVKAKYPNGAKIILLTGQPGSTSNIERTKGIRDELAAG-GDKYKIVVDQTGNWLRSEGLRIIESVLPTLKEKP 189 (292) T ss_dssp HHHHHHHHHHHHSTTCEEEEEEECCTTCHHHHHHHHHHHHHHHHH-CTTEEEEEEEECTTCHHHHHHHHHHHGGGCSSCC T ss_pred HHHHHHHHHHHHCCCCCeEEEEECCCCChhHHHHHHHHHHHHHhC-CCceEEEEeecCCCCHHHHHHHHHHHHHHcCCCC Confidence 788888887543 5668888775 3445667788888888764 3332211111100111122233334331 1357 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |+|++.. +..+..+++++++.|.. T Consensus 190 d~i~~~~-~~~a~~~~~~~~~~g~~ 213 (292) T 4RXM_A 190 EVIISAN-DDMALGAIEALRSQGLK 213 (292) T ss_dssp SEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CEEEECC-hHHHHHHHHHHHHCCCC Confidence 8865543 44566778888877763 No 178 >2HSG_A Glucose-resistance amylase regulator; CCPA, TRANSCRIPTIONAL REGULATOR, TRANSCRIPTION REGULATOR; 2.5A {Bacillus megaterium} SCOP: a.35.1.5, c.93.1.1 Probab=97.33 E-value=2.5e-07 Score=95.08 Aligned_cols=204 Identities=11% Similarity=0.117 Sum_probs=120.7 Template_Neff=11.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++..+..+++.++++.+ +++.+.|...++ ....+.++ T Consensus 57 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 110 (332) T 2HSG_A 57 SKKTTTVGVIIPDISN------------IFYAELARGIEDIATMYK----------YNIILSNSDQNQ----DKELHLLN 110 (332) T ss_pred cCCCCEEEEEeCCCCC------------hHHHHHHHHHHHHHHHhC----------CEEEEEeCCCCH----HHHHHHHH Confidence 4568899999987542 245667778888777642 233444543332 12233444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. +++|++|+...+. .......+...++|+|.++...+ .+..+.+.+++.. T Consensus 111 ~l~~-------------------~~~d~ii~~~~~~-~~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~~~~~ 163 (332) T 2HSG_A 111 NMLG-------------------KQVDGIIFMSGNV-TEEHVEELKKSPVPVVLAASIES-------TNQIPSVTIDYEQ 163 (332) T ss_pred HHHH-------------------cCCCEEEECCCCC-CHHHHHHHHHcCCCEEEeCCCCC-------CCCCcEEEEChHH Confidence 4332 4788888754443 23444556678999998765322 2345566677767 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) .+..+++++.+.+.++++++..+.. ++..+.++|++.+++. ++.+.....+..+.+..+....+++++. ..++|+ T Consensus 164 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ 242 (332) T 2HSG_A 164 AAFDAVQSLIDSGHKNIAFVSGTLEEPINHAKKVKGYKRALTES-GLPVRDSYIVEGDYTYDSGIEAVEKLLEEDEKPTA 242 (332) T ss_pred HHHHHHHHHHHCCCCcEEEEeCCcccChhHHHHHHHHHHHHHHC-CCCCCHHHcccCCCCHHHHHHHHHHHHHcCCCCCE Confidence 7777888876668889999985433 4567788888888764 3443321111110112233444555542 136788 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 243 i~~~~-~~~a~~~~~~l~~~g~~ 264 (332) T 2HSG_A 243 IFVGT-DEMALGVIHGAQDRGLN 264 (332) T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 87664 44566778888887763 No 179 >1ZHH_A Autoinducer 2-binding periplasmic protein luxP; PERIPLASMIC BINDING PROTEIN, PER/ARNT/SIMPLE-MINDED (PAS); HET: NHE; 1.94A {Vibrio harveyi} SCOP: c.93.1.1 Probab=97.33 E-value=2.5e-07 Score=95.67 Aligned_cols=220 Identities=11% Similarity=0.031 Sum_probs=124.3 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGV--RILDTCSRDTYALEQSLTF 119 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~--~~~d~~~~~~~a~~~~~~~ 119 (908) ..+.++||++.|..+.. .+......+++.++++.+ +++++ .+.|+..++. ...+. T Consensus 42 ~~~~~~Ig~i~~~~~~~-----------~~~~~~~~g~~~~~~~~g--------~~~~l~~~~~d~~~~~~----~~~~~ 98 (344) T 1ZHH_A 42 TQRPIKISVVYPGQQVS-----------DYWVRNIASFEKRLYKLN--------INYQLNQVFTRPNADIK----QQSLS 98 (344) T ss_dssp CSSCEEEEEEEESSCSS-----------CHHHHHHHHHHHHHHHTT--------CCEEEEEEEECTTSCHH----HHHHH T ss_pred CCCCeEEEEEeCCCCCC-----------HHHHHHHHHHHHHHHHcC--------CcEEEEEeecCCCCCHH----HHHHH Confidence 56789999999975321 233467788888888764 23333 4455444422 23333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRL-FKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~-~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+.........+.. .++|+|..+...+.... ...++++++.++ T Consensus 99 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~-~~~~~~~~v~~d 158 (344) T 1ZHH_A 99 LMEALK-------------------SKSDYLIFTLDTTRHRKFVEHVLDSTNTKLILQNITTPVREW-DKHQPFLYVGFD 158 (344) T ss_dssp THHHHH-------------------TTCSEEEECSCTTTTHHHHHHHHHHCSSEEEEESCCSCBGGG-TTSCCSEEEECC T ss_pred HHHHHh-------------------cCCCEEEEeCCchHhHHHHHHHHHhCCCeEEEEeCCCCchhh-ccCCCeEEEEec Confidence 444332 478888876543333333444444 79999987654432111 113567777788 Q NP_000836.2 199 DSYQAQAMVDIVTALGWN--YVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PN 274 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~--~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~ 274 (908) +...++.+++++.+.+.+ +++++..+ +.++..+.++|++.+++.+++.+....... .+..+....++++++. .+ T Consensus 159 ~~~~~~~~~~~l~~~~~~~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~ 236 (344) T 1ZHH_A 159 HAEGSRELATEFGKFFPKHTYYSVLYFSEGYISDVRGDTFIHQVNRDNNFELQSAYYTK--ATKQSGYDAAKASLAKHPD 236 (344) T ss_dssp HHHHHHHHHHHHHHHSCTTCEEEEECCSTTHHCCCCCCHHHHHHHHHHCCEEEEEECCC--SSHHHHHHHHHHHHHHCCC T ss_pred cHHHHHHHHHHHHHhCCCCceEEEEEcCCCchHHHHHHHHHHHHHhCCCcEEEEeeecC--CCHHHHHHHHHHHHHHCCC Confidence 777788888887654443 48888754 456667778888877754224433211111 1222344555555431 23 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +++|+.. ++..+..+++++++.|. .++.+++. T Consensus 237 ~~~i~~~-~~~~a~~~~~~l~~~g~-~~~~v~~~ 268 (344) T 1ZHH_A 237 VDFIYAC-STDVALGAVDALAELGR-EDIMINGW 268 (344) T ss_dssp CSEEEES-SHHHHHHHHHHHHHHTC-TTSEEBCS T ss_pred ccEEEEC-ChHHHHHHHHHHHHcCC-CCcEEEEe Confidence 4555544 34455668888888776 23344443 No 180 >5ULB_A Putative sugar ABC transporter; ABC transporter, Methylthioribose-binding protein, Structural; HET: MSE, 8GG, 8GA; 1.28A {Yersinia enterocolitica subsp. enterocolitica 8081} Probab=97.32 E-value=2.6e-07 Score=95.13 Aligned_cols=217 Identities=12% Similarity=0.087 Sum_probs=123.7 Template_Neff=11.700 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ......+.++||++.|..+. .++..+..+++.++++.| +++.+.|+..+. +... T Consensus 12 ~~~~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~----~~~~ 65 (337) T 5ULB_A 12 AIAKHQGQIKIAVIRNLGSD------------DNTTQFLSGVLKEGKKLG----------FKVDTFLSNGDD----ARFQ 65 (337) T ss_dssp HHHTCSSCCEEEEEESSCSC------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCH----HHHH T ss_pred HHHhccCCcEEEEEEeCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEeCCCCH----HHHH Confidence 34566788999999997653 245677788888887753 334445544332 1223 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAA-SSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~-s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +.+++++. .+++++|+... +.........+...++|+|..+...+. ..++++++. T Consensus 66 ~~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~~~ 121 (337) T 5ULB_A 66 DFVNQAIS-------------------QKYDGIILSQGRDPYSTELVKRIVANGIAVSVFDTAIQG-----DIPGLTVTQ 121 (337) T ss_dssp HHHHHHHH-------------------TTCSEEEEESCCTTTHHHHHHHHHHTTCEEEEESCCCCS-----CCTTCEEEE T ss_pred HHHHHHHh-------------------CCCCEEEEcCCCCccCHHHHHHHHHCCCeEEEEccCCCC-----CCCCeEEEe Confidence 33444332 47888776543 222234445566789999987654331 124556666 Q NP_000836.2 197 PPDSYQAQAMVDIVTA--LGWNYVSTLA-SEGNYGESGVEAFTQISREIGGVCIAQSQK--IPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~--~~~~~v~ii~-~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~--~~~~~~~~~~~~~~~~l~~ 271 (908) +++...+..+++++.+ .+.++++++. .+..++..+.++|++.+++.+++.+..... +. ....+....+++++. T Consensus 122 ~~~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~ 199 (337) T 5ULB_A 122 QDDASLTNESFGQLVKDFNGKANIIKLWVAGFPPMERRQAAYQALLKQNPGITELESIGAVSS--DVQGDTANKVGAVLA 199 (337) T ss_dssp ECHHHHHHHHHHHHHHHTTTCEEEEEECCTTSHHHHHHHHHHHHHHHHCTTEEEEEEECCCCT--THHHHHHHHHHHHHH T ss_pred cCchHHHHHHHHHHHHhhCCCccEEEEEcCCChhHHHHHHHHHHHHHhCCCcEEEEEEccCCC--CCCcchHHHHHHHHH Confidence 6666566666666544 4678899884 334556677788888777642244332111 11 111123344555542 Q NP_000836.2 272 T-P--NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 272 ~-~--~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) . . ++++|++.. +..+..+++++++.|+. ++.+++. T Consensus 200 ~~~~~~~~~i~~~~-~~~a~~~~~al~~~g~~-~i~v~~~ 237 (337) T 5ULB_A 200 KYPKGKIDAIWGTW-DAFTQGAYKALQENGRT-EIKLYSI 237 (337) T ss_dssp HSCTTSCCEEEESS-HHHHHHHHHHHHHTTCT-TSEEEEE T ss_pred hCCCCCeeEEEECC-chHHHHHHHHHHHcCCC-CCEEEEE Confidence 1 1 347776664 44466788888887762 3444443 No 181 >2FEP_A Catabolite control protein A, Phosphocarrier; CcpA, HPr, transcriptional regulator, TRANSCRIPTION; HET: SO4; 2.45A {Bacillus subtilis} Probab=97.32 E-value=2.7e-07 Score=92.60 Aligned_cols=206 Identities=9% Similarity=0.056 Sum_probs=118.1 Template_Neff=11.700 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+..+||++.|..+. .++.....+++.++++.+ +++ .+.+...++ ....+. T Consensus 11 ~~~~~~~~igvi~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~--~~~~~~~~~----~~~~~~ 64 (289) T 2FEP_A 11 GSSKKTTTVGVIIPDISS------------IFYSELARGIEDIATMYK--------YNI--ILSNSDQNM----EKELHL 64 (289) T ss_dssp -----CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------CEE--EEEECTTCH----HHHHHH T ss_pred CCCCCccEEEEEeCCCCc------------HHHHHHHHHHHHHHHHcC--------CcE--EEEeCCCCH----HHHHHH Confidence 345678899999987542 255677788887777642 333 334433332 222333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++++. ++++++|+...+.. ......+...++|+|..+...+ .+..+.+..++ T Consensus 65 ~~~l~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~ 117 (289) T 2FEP_A 65 LNTMLG-------------------KQVDGIVFMGGNIT-DEHVAEFKRSPVPIVLAASVEE-------QEETPSVAIDY 117 (289) T ss_dssp HHHHHH-------------------TTCSEEEECCSCCC-HHHHHHHHHSSSCEEEESCCCT-------TCCSCEEECCH T ss_pred HHHHhc-------------------CCCCEEEEeCCCCC-HHHHHHHHhCCCCEEEEcCCCC-------CCCCCEEEeCH Confidence 443332 47888887554433 3444556678999998765432 13455666777 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYG---ESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNA 275 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~---~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~ 275 (908) ...++.+++++.+.+.++++++..+..++ ..+.+++++.+++. ++.+........+.+..+....++++++ ..++ T Consensus 118 ~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 196 (289) T 2FEP_A 118 EQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEA-NLPFNEQFVAEGDYTYDSGLEALQHLMSLDKKP 196 (289) T ss_dssp HHHHHHHHHHHHHTTCSSEEEEESCTTSHCCCCCCHHHHHHHHHHT-TCCCCGGGEEECCSCHHHHHHHHHHHTTSSSCC T ss_pred HHHHHHHHHHHHHCCCCcEEEEeCCCCCCccHHHHHHHHHHHHHHC-CCCCCHHHhccCCCCcchHHHHHHHHHhcCCCC Confidence 77777888887666888999998654433 56677888877764 2332211111100111233344555542 1367 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |+|++.. +..+..+++++++.|+. T Consensus 197 d~i~~~~-~~~~~~~~~~l~~~g~~ 220 (289) T 2FEP_A 197 TAILSAT-DEMALGIIHAAQDQGLS 220 (289) T ss_dssp SEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CEEEECC-cHHHHHHHHHHHHCCCC Confidence 8887664 44567778888877764 No 182 >2IKS_A DNA-binding transcriptional dual regulator; DNA-binding transcriptional dual regulator, Escherichia; 1.85A {Escherichia coli} Probab=97.31 E-value=2.7e-07 Score=92.64 Aligned_cols=204 Identities=11% Similarity=0.090 Sum_probs=117.9 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...+.++||++.|..+. .++.....+++.++++.+ +++.+.+...+. +...+.+ T Consensus 16 ~~~~~~~Ig~~~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~ 69 (293) T 2IKS_A 16 RAGRTRSIGLVIPDLEN------------TSYTRIANYLERQARQRG----------YQLLIACSEDQP----DNEMRCI 69 (293) T ss_dssp --CCCCEEEEEESCSCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHH T ss_pred hcCCCCEEEEEecCCCC------------hHHHHHHHHHHHHHHHcC----------CeEEEEeCCCCH----HHHHHHH Confidence 44578999999987542 245667778887777642 233344443332 2223334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. ++++++|+...+.........+...++|+|..+...+. +..+.+..++. T Consensus 70 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~-------~~~~~~~~~~~ 123 (293) T 2IKS_A 70 EHLLQ-------------------RQVDAIIVSTSLPPEHPFYQRWANDPFPIVALDRALDR-------EHFTSVVGADQ 123 (293) T ss_dssp HHHHH-------------------TTCSEEEECCSSCTTCHHHHTTTTSSSCEEEEESCCCT-------TTCEEEEECHH T ss_pred HHHHh-------------------CCCCEEEECCCCCCCchHHHHHHcCCCCEEEEcCCcCc-------ccCcEEEeCcH Confidence 43332 47888887554433333445566789999987764331 23455666666 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ..+..+++++.+.+.++++++.. +..+...+.++|++.+++. ++.+....... .+..+....++++++. .++|+ T Consensus 124 ~~~~~~~~~l~~~g~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~d~ 200 (293) T 2IKS_A 124 DDAEMLAEELRKFPAETVLYLGALPELSVSFLREQGFRTAWKDD-PREVHFLYANS--YEREAAAQLFEKWLETHPMPQA 200 (293) T ss_dssp HHHHHHHHHHHTSCCSSEEEEEECTTSHHHHHHHHHHHHHHTTC-CCCEEEEEESS--SCHHHHHHHHHHHTTTSCCCSE T ss_pred HHHHHHHHHHHhCCCcEEEEEeCCccchhHHHHHHHHHHHHHhC-CCceeeeecCC--CCHHHHHHHHHHHHHhCCCCCE Confidence 66777788776667889999985 3345666778888887764 34433211111 1112233445555421 24777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++.+.|.. T Consensus 201 i~~~~-~~~a~~~~~~~~~~~~~ 222 (293) T 2IKS_A 201 LFTTS-FALLQGVMDVTLRRDGK 222 (293) T ss_dssp EEESS-HHHHHHHHHHHHHHHSS T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 77654 44456677777776653 No 183 >3D8U_A PurR transcriptional regulator; APC91343.1, PurR, transcriptional regulator, Vibrio; HET: MSE; 2.88A {Vibrio parahaemolyticus} Probab=97.31 E-value=2.7e-07 Score=91.46 Aligned_cols=202 Identities=12% Similarity=0.082 Sum_probs=116.7 Template_Neff=12.400 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ++++||++.|.... .++..+..+++.++++.+ +++.+.++..++ +...+.++++ T Consensus 2 ~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~~~ 55 (275) T 3D8U_A 2 NAYSIALIIPSLFE------------KACAHFLPSFQQALNKAG----------YQLLLGYSDYSI----EQEEKLLSTF 55 (275) T ss_dssp --CEEEEEESCSSC------------HHHHHHHHHHHHHHHHTS----------CEECCEECTTCH----HHHHHHHHHH T ss_pred CcceEEEEeCccCC------------hhHHHHHHHHHHHHHHcC----------CEEEEEeCCCCH----HHHHHHHHHH Confidence 46889999987532 245667778887777642 233444443332 1223334433 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) +. .+++++|+...+... .....+...++|+|..+...+ .++.+.+..+....+ T Consensus 56 ~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~~~~ 108 (275) T 3D8U_A 56 LE-------------------SRPAGVVLFGSEHSQ-RTHQLLEASNTPVLEIAELSS-------KASYLNIGVDHFEVG 108 (275) T ss_dssp HT-------------------SCCCCEEEESSCCCH-HHHHHHHHHTCCEEEESSSCS-------SSSSEEECBCHHHHH T ss_pred HH-------------------hCCCEEEEeCCCCCH-HHHHHHHhCCCCEEEEcCCCC-------CCCCcEEEeCHHHHH Confidence 32 478888875544333 344556678999988765432 134566677777777 Q NP_000836.2 204 QAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAVIM 280 (908) Q Consensus 204 ~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~viv~ 280 (908) +.+++++.+.+.++++++..+.. .+..+.++|++.+++. ++.+..........+..+....++++++ ..++|+|++ T Consensus 109 ~~~~~~l~~~g~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~d~i~~ 187 (275) T 3D8U_A 109 KACTRHLIEQGFKNVGFIGARGNHSTLQRQLHGWQSAMIEN-YLTPDHFLTTHEAPSSQLGAEGLAKLLLRDSSLNALVC 187 (275) T ss_dssp HHHHHHHHTTTCCCEEEEECSCSSHHHHHHHHHHHHHHHHT-TCCCCCEEECSSCCCHHHHHHHHHHHHTTCTTCCEEEE T ss_pred HHHHHHHHHCCCCcEEEEecCCCchHHHHHHHHHHHHHHHC-CCCcceEEecCCCCchhhHHHHHHHHHhcCCCCCEEEE Confidence 78888876668889999985443 4556777888877764 3433211111100111223344555542 134788876 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~ 300 (908) .. +..+..+++++++.|+. T Consensus 188 ~~-~~~~~~~~~~~~~~g~~ 206 (275) T 3D8U_A 188 SH-EEIAIGALFECHRRVLK 206 (275) T ss_dssp SS-HHHHHHHHHHHHHTTCC T ss_pred CC-HHHHHHHHHHHHHCCCC Confidence 64 35566778888877763 No 184 >3D8U_B PurR transcriptional regulator; APC91343.1, PurR, transcriptional regulator, Vibrio; 2.88A {Vibrio parahaemolyticus} Probab=97.31 E-value=2.7e-07 Score=91.46 Aligned_cols=202 Identities=12% Similarity=0.082 Sum_probs=116.7 Template_Neff=12.400 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ++++||++.|.... .++..+..+++.++++.+ +++.+.++..++ +...+.++++ T Consensus 2 ~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~~~ 55 (275) T 3D8U_B 2 NAYSIALIIPSLFE------------KACAHFLPSFQQALNKAG----------YQLLLGYSDYSI----EQEEKLLSTF 55 (275) T ss_dssp --CCEEEEESCSSC------------HHHHHHHHHHHHHHHHHT----------CCEEEEECSSCH----HHHHHHHHHH T ss_pred CcceEEEEeCccCC------------hhHHHHHHHHHHHHHHcC----------CEEEEEeCCCCH----HHHHHHHHHH Confidence 46889999987532 245667778887777642 233444443332 1223334433 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) +. .+++++|+...+... .....+...++|+|..+...+ .++.+.+..+....+ T Consensus 56 ~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~~~~ 108 (275) T 3D8U_B 56 LE-------------------SRPAGVVLFGSEHSQ-RTHQLLEASNTPVLEIAELSS-------KASYLNIGVDHFEVG 108 (275) T ss_dssp HT-------------------TCCSCEEEESSCCCH-HHHHHHHHTTCCEEEESSSCS-------SSSCEEECCCHHHHH T ss_pred HH-------------------hCCCEEEEeCCCCCH-HHHHHHHhCCCCEEEEcCCCC-------CCCCcEEEeCHHHHH Confidence 32 478888875544333 344556678999988765432 134566677777777 Q NP_000836.2 204 QAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAVIM 280 (908) Q Consensus 204 ~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~viv~ 280 (908) +.+++++.+.+.++++++..+.. .+..+.++|++.+++. ++.+..........+..+....++++++ ..++|+|++ T Consensus 109 ~~~~~~l~~~g~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~d~i~~ 187 (275) T 3D8U_B 109 KACTRHLIEQGFKNVGFIGARGNHSTLQRQLHGWQSAMIEN-YLTPDHFLTTHEAPSSQLGAEGLAKLLLRDSSLNALVC 187 (275) T ss_dssp HHHHHHHHHTTCCCEEEEEECTTSHHHHHHHHHHHHHHHHT-TCCCCCEEEESSCCCHHHHHHHHHHHHHHCTTCCEEEE T ss_pred HHHHHHHHHCCCCcEEEEecCCCchHHHHHHHHHHHHHHHC-CCCcceEEecCCCCchhhHHHHHHHHHhcCCCCCEEEE Confidence 78888876668889999985443 4556777888877764 3433211111100111223344555542 134788876 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~ 300 (908) .. +..+..+++++++.|+. T Consensus 188 ~~-~~~~~~~~~~~~~~g~~ 206 (275) T 3D8U_B 188 SH-EEIAIGALFECHRRVLK 206 (275) T ss_dssp SS-HHHHHHHHHHHHHHTCC T ss_pred CC-HHHHHHHHHHHHHCCCC Confidence 64 35566778888877763 No 185 >1JHZ_B PURINE NUCLEOTIDE SYNTHESIS REPRESSOR; corepressor binding domain, purine repressor; 2.4A {Escherichia coli} SCOP: c.93.1.1 Probab=97.31 E-value=2.7e-07 Score=92.37 Aligned_cols=206 Identities=14% Similarity=0.127 Sum_probs=112.9 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++..+||++.|..+. .++..+..+++.++++.| +++.+.++..++ +...+.+ T Consensus 3 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~ 56 (289) T 1JHZ_B 3 KVNHTKSIGLLATSSEA------------AYFAEIIEAVEKNCFQKG----------YTLILGNAWNNL----EKQRAYL 56 (289) T ss_dssp -----CEEEEEESCSSC------------HHHHHHHHHHHHHHHHTT----------CEEEEEECCSCH----HHHHHHH T ss_pred ccCCcceEEEEeCCCCC------------hhHHHHHHHHHHHHHHhC----------CeEEEEecCCCH----HHHHHHH Confidence 34567899999987542 245667778887777643 233444443332 2223334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILR-LFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~-~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++.. .++|++|+...+... .....+. ..++|+|..+...+. .++.+.+..++ T Consensus 57 ~~~~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~~~ 110 (289) T 1JHZ_B 57 SMMAQ-------------------KRVDGLLVMCSEYPE-PLLAMLEEYRHIPMVVMDFGEAK------ADFTDAVIDNA 110 (289) T ss_dssp HHHHH-------------------TTCSCCCEECSCCCH-HHHHHHHHTTTSCCCEEEESSCC------TTSCCEEECCH T ss_pred HHHHh-------------------cCCCEEEEecCCCCH-HHHHHHHHhCCCCEEEeeCCCcc------ccCceEEEeCh Confidence 43332 478888875443222 2233333 479999987654321 23445566666 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ...++.+++++.+.+.++++++.. +..++..+.++|++.+++. ++.+..........+..+....++++++. .+++ T Consensus 111 ~~~~~~~~~~l~~~~~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~ 189 (289) T 1JHZ_B 111 FEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEA-MIKVPESWIVQGDFEPESGYRAMQQILSQPHRPT 189 (289) T ss_dssp HHHHHHHHHHHHHTTCCSEEEECCC------CHHHHHHHHHHHHT-TCCCCGGGBCCCCSSHHHHHHHHHHHHSSSSCCS T ss_pred HHHHHHHHHHHHHCCCCcEEEeeCCCCccChHHHHHHHHHHHHHc-CCCCCHHHeeecCCChHHHHHHHHHHHhCCCCCc Confidence 677778888886667889999985 3345667778888888765 34433211011001112333445555421 2467 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +|++.. +..+..+++++++.|+. T Consensus 190 ~i~~~~-~~~~~~~~~~l~~~g~~ 212 (289) T 1JHZ_B 190 AVFCGG-DIMAMGALCAADEMGLR 212 (289) T ss_dssp EEEESC-HHHHHHHHHHHHHHTCC T ss_pred EEEECC-HHHHHHHHHHHHHCCCC Confidence 776654 44556778888877763 No 186 >2P9H_A Lactose operon repressor; Lac repressor, allosteric effectors, gene; HET: IPT; 2.0A {Escherichia coli} SCOP: c.93.1.1 Probab=97.30 E-value=2.8e-07 Score=91.05 Aligned_cols=199 Identities=12% Similarity=0.076 Sum_probs=116.1 Template_Neff=12.200 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIE 125 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~~ 125 (908) ++||++.|..+. .++..+..+++.++++.+ +++.+...+. .++ +...+.+++++. T Consensus 1 ~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~~~~~~~~~l~~ 55 (269) T 2P9H_A 1 LLIGVATSSLAL------------HAPSQIVAAIKSRADQLG--------ASVVVSMVER-SGV----EACKAAVHNLLA 55 (269) T ss_dssp CEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT--------CEEEEEECCS-SSH----HHHHHHHHHHHT T ss_pred CeEEEEeCcccc------------cchHHHHHHHHHHHHHcC--------CcEEEEEccC-CcH----HHHHHHHHHHHh Confidence 478999887542 255677788888887753 3344333222 111 122233443332 Q NP_000836.2 126 KDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQA 205 (908) Q Consensus 126 ~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~ 205 (908) .+++++|+...+.........+...++|+|..+...+ ++++++.+++...++. T Consensus 56 -------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~--------~~~~~v~~d~~~~~~~ 108 (269) T 2P9H_A 56 -------------------QRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQ--------TPINSIIFSHEDGTRL 108 (269) T ss_dssp -------------------TTCSEEEEESCCCHHHHHHHHHHTTTSCEEESSSCTT--------SSSCEEEECHHHHHHH T ss_pred -------------------CCCCEEEEeCCCCChHHHHHHHHHcCCCEEEeeCCCC--------CCCCEEEECChHHHHH Confidence 4788888764443322222345678999998765432 2456667777777778 Q NP_000836.2 206 MVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAVIMFA 282 (908) Q Consensus 206 ~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~viv~~~ 282 (908) +++++.+.+.++++++.. ++.++..+.+++++.+++. ++++....... .+..+....+++++.. .++|+|++.. T Consensus 109 ~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~d~i~~~~ 185 (269) T 2P9H_A 109 GVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRN-QIQPIAEREGD--WSAMSGFQQTMQMLNEGIVPTAMLVAN 185 (269) T ss_dssp HHHHHHHHTCCCEEEEECCTTSHHHHHHHHHHHHHHHHT-TCCCSEEEECC--SSHHHHHHHHHHHHHTTCCCSEEEESS T ss_pred HHHHHHHCCCCcEEEEeCCcCCHHHHHHHHHHHHHHHHC-CCCCceeecCC--CchhHHHHHHHHHHhcCCCCCEEEECC Confidence 888876667889999885 3345667778888888775 35443221111 1112233445555421 2477776664 Q NP_000836.2 283 NEDDIRRILEAAKKLNQS 300 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~ 300 (908) +..+..+++++++.|.. T Consensus 186 -~~~~~~~~~~l~~~~~~ 202 (269) T 2P9H_A 186 -DQMALGAMRAITESGLR 202 (269) T ss_dssp -HHHHHHHHHHHHHTTCC T ss_pred -HHHHHHHHHHHHHcCCC Confidence 34466777788777764 No 187 >2PAF_B Lactose operon repressor; Lac repressor, allosteric effectors, gene; HET: NPF; 3.5A {Escherichia coli} SCOP: c.93.1.1 Probab=97.30 E-value=2.8e-07 Score=91.05 Aligned_cols=199 Identities=12% Similarity=0.076 Sum_probs=116.1 Template_Neff=12.200 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIE 125 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~~ 125 (908) ++||++.|..+. .++..+..+++.++++.+ +++.+...+. .++ +...+.+++++. T Consensus 1 ~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~~~~~~~~~l~~ 55 (269) T 2PAF_B 1 LLIGVATSSLAL------------HAPSQIVAAIKSRADQLG--------ASVVVSMVER-SGV----EACKAAVHNLLA 55 (269) T ss_dssp CEEEEEESCTTS------------HHHHHHHHHHHHHHGGGT--------CEEEEEECCS-SSH----HHHHHHHHHHHT T ss_pred CeEEEEeCcccc------------cchHHHHHHHHHHHHHcC--------CcEEEEEccC-CcH----HHHHHHHHHHHh Confidence 478999887542 255677788888887753 3344333222 111 122233443332 Q NP_000836.2 126 KDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQA 205 (908) Q Consensus 126 ~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~ 205 (908) .+++++|+...+.........+...++|+|..+...+ ++++++.+++...++. T Consensus 56 -------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~--------~~~~~v~~d~~~~~~~ 108 (269) T 2PAF_B 56 -------------------QRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQ--------TPINSIIFSHEDGTRL 108 (269) T ss_dssp -------------------TTCSEEEEESCCCHHHHHHHHHHTCSSCEEESSSCTT--------SCSSEEEECHHHHHHH T ss_pred -------------------CCCCEEEEeCCCCChHHHHHHHHHcCCCEEEeeCCCC--------CCCCEEEECChHHHHH Confidence 4788888764443322222345678999998765432 2456667777777778 Q NP_000836.2 206 MVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAVIMFA 282 (908) Q Consensus 206 ~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~viv~~~ 282 (908) +++++.+.+.++++++.. ++.++..+.+++++.+++. ++++....... .+..+....+++++.. .++|+|++.. T Consensus 109 ~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~d~i~~~~ 185 (269) T 2PAF_B 109 GVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRN-QIQPIAEREGD--WSAMSGFQQTMQMLNEGIVPTAMLVAN 185 (269) T ss_dssp HHHHHHTTTCCCEEEEECCTTSHHHHHHHHHHHHHHHTT-TCCCSCEEECC--SCHHHHHHTHHHHGGGTCCCSEEEESS T ss_pred HHHHHHHCCCCcEEEEeCCcCCHHHHHHHHHHHHHHHHC-CCCCceeecCC--CchhHHHHHHHHHHhcCCCCCEEEECC Confidence 888876667889999885 3345667778888888775 35443221111 1112233445555421 2477776664 Q NP_000836.2 283 NEDDIRRILEAAKKLNQS 300 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~ 300 (908) +..+..+++++++.|.. T Consensus 186 -~~~~~~~~~~l~~~~~~ 202 (269) T 2PAF_B 186 -DQMALGAMRAITESGLR 202 (269) T ss_dssp -HHHHHHHHHHHHHTTCC T ss_pred -HHHHHHHHHHHHHcCCC Confidence 34466777788777764 No 188 >3K4H_A putative transcriptional regulator; STRUCTURAL GENOMICS, CRYSTAL STRUCTURE,PROTEIN STRUCTURE; HET: MAL; 2.8A {Bacillus cytotoxicus NVH 391-98} Probab=97.30 E-value=2.9e-07 Score=92.38 Aligned_cols=210 Identities=10% Similarity=0.048 Sum_probs=120.5 Template_Neff=11.900 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|.++.... ...++..+..+++.++++.+ +++ .+.|...+. +...+.++ T Consensus 5 ~~~~~~Ig~v~~~~~~~~~-------~~~~~~~~~~~~~~~~~~~g--------~~~--~~~~~~~~~----~~~~~~~~ 63 (292) T 3K4H_A 5 NQTTKTLGLVMPSSASKAF-------QNPFFPEVIRGISSFAHVEG--------YAL--YMSTGETEE----EIFNGVVK 63 (292) T ss_dssp --CCCEEEEECSSCHHHHT-------TSTHHHHHHHHHHHHHHHTT--------CEE--EECCCCSHH----HHHHHHHH T ss_pred cCCCCEEEEEecCchhhhh-------cCCcHHHHHHHHHHHHHHcC--------cEE--EEECCCChH----HHHHHHHH Confidence 4568999999998641000 01355677788888877642 233 333432221 11222222 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) .+.. .+++++|+...+.. ......+...++|+|..+...+. .++++++.++... T Consensus 64 ~~~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~~ 117 (292) T 3K4H_A 64 MVQG-------------------RQIGGIILLYSREN-DRIIQYLHEQNFPFVLIGKPYDR------KDEITYVDNDNYT 117 (292) T ss_dssp HHHT-------------------TCCCEEEESCCBTT-CHHHHHHHHTTCCEEEESCCSSC------TTTSCEEECCHHH T ss_pred HHHc-------------------CCCCEEEEecccCC-hHHHHHHHHCCCCEEEeCCCCCC------CCCccEEEcCHHH Confidence 2221 47888887654433 34445566789999987764431 2456777788877 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .++.+++++.+.+.++++++.. +...+..+.++|++.+++. ++.+........+.+..+....++++++ ..++|+| T Consensus 118 ~~~~~~~~l~~~g~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d~i 196 (292) T 3K4H_A 118 AAREVAEYLISLGHKQIAFIGGGSDLLVTRDRLAGMSDALKLA-DIVLPKEYILHFDFSRESGQQAVEELMGLQQPPTAI 196 (292) T ss_dssp HHHHHHHHHHHTTCCCEEEEESCTTBHHHHHHHHHHHHHHHHT-TCCCCGGGEEECCSSHHHHHHHHHHHHTSSSCCSEE T ss_pred HHHHHHHHHHHCCCCeEEEEcCCcccHHHHHHHHHHHHHHHHc-CCCCChhheeccCCCHHHHHHHHHHHHhcCCCCCEE Confidence 8888888887668889999985 3345566778888887764 3444321111100111233344455442 1367787 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 197 ~~~~-~~~a~~~~~~~~~~g~~ 217 (292) T 3K4H_A 197 MATD-DLIGLGVLSALSKKGFV 217 (292) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-hHHHHHHHHHHHHcCCC Confidence 7664 44566778888877763 No 189 >4RXT_A Sugar ABC transporter; SUGAR TRANSPORTER, ABC-TYPE, ENZYME FUNCTION; HET: ARA; 1.35A {Agrobacterium radiobacter} Probab=97.30 E-value=3e-07 Score=92.78 Aligned_cols=213 Identities=11% Similarity=0.021 Sum_probs=120.7 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||++.|.++. .++.....+++.++++. |+++.+...|+..+. +...+.+++ T Consensus 2 ~~~~~Igvi~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~~~~~~~~~~~~~----~~~~~~~~~ 57 (299) T 4RXT_A 2 MAEVTIPIIVKDTTS------------FYWQIVLAGARKAGKDL--------GVKVPELGAQAETDV----NGQISILEN 57 (299) T ss_dssp TTCCBCCEEESCTTS------------HHHHHHHHHHHHHHHHH--------TCBCCEEECSCTTCH----HHHHHHHHH T ss_pred CCCeEEEEEeccCCC------------hhHHHHHHHHHHHHHHh--------CCEEEEecCCcCCCH----HHHHHHHHH Confidence 357899999997542 25567778888888775 344555444432222 122333443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +.. ++++++|+...+.... .....+ ..++|++..+...+. .++.+++.+++.. T Consensus 58 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~-~~~ipvv~~~~~~~~------~~~~~~v~~d~~~ 111 (299) T 4RXT_A 58 AVA-------------------GKPAAIVISPTEFKALGKPVDEA-AKSVPIIGIDSGADS------KAFKSFLTTDNTQ 111 (299) T ss_dssp HHH-------------------TCCSCEEECCSSTTTTHHHHHHH-HTTSCEEEESSCCSC------SCCSEEEECCHHH T ss_pred HHh-------------------CCCCEEEECCCChHhccHHHHHH-HhCCCEEEEccCCCc------ccccEEEecCHHH Confidence 332 4788887654443321 233334 579999987654321 2445677777777 Q NP_000836.2 202 QAQAMVDIVTA-------LGWNYVSTLAS--EGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 202 ~~~~~~~~l~~-------~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) .++.+++++.+ .+.++++++.. +..++..+.++|++.+++.+ ++++....... .+..+....++++.+ T Consensus 112 ~~~~~~~~l~~~l~~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~ 189 (299) T 4RXT_A 112 GGRIAADGLAAAIKAMTGKEEGDVVIITNTPGAGSLEQRRTGFLDQVKTKYPGLKVVADKYAD--GQATTGLNIMTDLIT 189 (299) T ss_dssp HHHHHHHHHHHHHHHHHSSSCEEEEEEESSTTCHHHHHHHHHHHHHHHHHCTTEEEEEEEECC--SCHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHhhCCCCceEEEEEcCCCCchHHHHHHHHHHHHHHHCCCcEEeeeecCC--CCHHHHHHHHHHHHH Confidence 77777777654 36789999985 33456677788888776531 23332211111 111233444555542 Q NP_000836.2 272 -TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 272 -~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ..++++|++.. +..+..+++++++.|...++.+++. T Consensus 190 ~~~~~~~i~~~~-~~~a~~~~~~l~~~g~~~~i~i~g~ 226 (299) T 4RXT_A 190 ANPKIVGVFASN-LIMAQGVGQAIAENKLSDKVKVIGF 226 (299) T ss_dssp HCTTEEEEEECS-HHHHHHHHHHHHHTTCTTTCEEEEE T ss_pred HCCCccEEEECC-hhhHHHHHHHHHHCCCCCCeEEEEE Confidence 12456665553 4456678888888776323444443 No 190 >4ZJP_A solute binding protein; Solute binding protein, ENZYME FUNCTION; HET: MSE, RIP, EDO; 1.63A {Actinobacillus succinogenes (strain ATCC 55618 / 130Z)} Probab=97.29 E-value=3e-07 Score=92.30 Aligned_cols=206 Identities=13% Similarity=0.068 Sum_probs=115.9 Template_Neff=11.800 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) .....++.++||++.|..+. .++.....+++.++++.| +++.+.|+..++. ... T Consensus 17 ~~~~~~~~~~Ig~v~~~~~~------------~~~~~~~~~~~~~~~~~~----------~~~~~~~~~~~~~----~~~ 70 (292) T 4ZJP_A 17 NLYFQSMQETIALTVSTLDN------------PFFVSLKDGAQKKATELG----------YKLVVLDSQNDPS----KEL 70 (292) T ss_dssp ------CCCEEEEEESCSSS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCHH----HHH T ss_pred ccccccCCcEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCHH----HHH Confidence 34566789999999997542 255677788888887753 3344455443322 222 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIG-AAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg-~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +.++++.. ++++++|. +..+.........+...++|+|..+...+. .++++++. T Consensus 71 ~~~~~l~~-------------------~~~~~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~ 125 (292) T 4ZJP_A 71 SNVEDLTV-------------------RGAKVLLINPTDSAAVSNAVAIANRNKIPVITLDRGAAK------GEVVSHIA 125 (292) T ss_dssp HHHHHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCSS------SCCSEEEE T ss_pred HHHHHHHh-------------------CCCCEEEEcCCChhHHHHHHHHHHHCCCCEEEECCCCCC------CCceEEEE Confidence 33333332 35665554 333332224445566789999987654321 34677888 Q NP_000836.2 197 PPDSYQAQAMVDIVTAL---GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~~---~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) +++...++.+++++.+. +.+ ++++.. ++.++..+.+++++.+++. ++.+....... .+..+....++++++ T Consensus 126 ~d~~~~~~~~~~~l~~~~~~~~~-~~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~ 201 (292) T 4ZJP_A 126 SDNVAGGKMAGDFIAQKLGDGAK-VIQLEGLAGTSAARERGEGFKQAIEAH-KFDVLASQPAD--FDRTKGLNVTENLLA 201 (292) T ss_dssp ECHHHHHHHHHHHHHHHHCTTCE-EEEEECCTTSHHHHHHHHHHHHHHHHH-TCEEEEEEECT--TCHHHHHHHHHHHHH T ss_pred cChHHHHHHHHHHHHHHhCCCcE-EEEEECCCCCHHHHHHHHHHHHHHHhc-CCeEEEeecCC--CCHHHHHHHHHHHHH Confidence 88888888888887543 344 555543 3456677788888888775 35443221111 112234445555542 Q NP_000836.2 272 T-PNARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 272 ~-~~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) . .++++|++.. +..+..+++++++.|. T Consensus 202 ~~~~~~~i~~~~-~~~a~~~~~~~~~~g~ 229 (292) T 4ZJP_A 202 SKGSVQAIFAQN-DEMALGALRAISAAGK 229 (292) T ss_dssp HSTTCCEEEESS-HHHHHHHHHHHHHHTC T ss_pred hcCCCCEEEECC-hHHHHHHHHHHHHCCC Confidence 1 2456665543 4456678888887775 No 191 >2VK2_A ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ; TRANSPORT PROTEIN, ABC TRANSPORT, GALACTOFURANOSE; HET: GZL; 1.2A {ESCHERICHIA COLI} Probab=97.28 E-value=3.2e-07 Score=92.93 Aligned_cols=205 Identities=11% Similarity=0.090 Sum_probs=118.5 Template_Neff=11.600 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|.+.. .++.....+++.++++.| +++.+.|...++ +...+.+++++ T Consensus 2 ~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~~l~ 55 (306) T 2VK2_A 2 PLTVGFSQVGSES------------GWRAAETNVAKSEAEKRG----------ITLKIADGQQKQ----ENQIKAVRSFV 55 (306) T ss_dssp CCEEEEEECCCCS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCH----HHHHHHHHHHH T ss_pred CcEEEEEecCCCC------------hHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCH----HHHHHHHHHHH Confidence 5789999997632 245566677777777653 344455544332 22333444433 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++|....... .......+...++|+|..+...+.. ...++++++.+++...+ T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~---~~~~~~~~v~~d~~~~~ 113 (306) T 2VK2_A 56 A-------------------QGVDAIFIAPVVATGWEPVLKEAKDAEIPVFLLDRSIDVK---DKSLYMTTVTADNILEG 113 (306) T ss_dssp H-------------------HTCSEEEECCSSSSSCHHHHHHHHHTTCCEEEESSCCCCS---CGGGSSEEEECCHHHHH T ss_pred H-------------------cCCCEEEEcCCCccChHHHHHHHHHCCCCEEEECCCCCCC---CccceEEEEecChHHHH Confidence 2 46776665433322 2244455677899999877644321 01245677778887778 Q NP_000836.2 204 QAMVDIVTALGWN---YVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET----PN 274 (908) Q Consensus 204 ~~~~~~l~~~~~~---~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~----~~ 274 (908) +.+++++.+.+.+ +++++.. ++.++..+.++|++.+++.+.+++....... .+..+....+++++.. .+ T Consensus 114 ~~~~~~l~~~~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~~ 191 (306) T 2VK2_A 114 KLIGDWLVKEVNGKPCNVVELQGTVGASVAIDRKKGFAEAIKNAPNIKIIRSQSGD--FTRSKGKEVMESFIKAENNGKN 191 (306) T ss_dssp HHHHHHHHHHHTTSCEEEEEEECSTTCHHHHHHHHHHHHHTTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHTTTTTT T ss_pred HHHHHHHHHHhCCCCceEEEEEcCCCCHHHHHHHHHHHHHHHhCCCeEEEeeecCC--CCHHHHHHHHHHHHHHhcCCCC Confidence 8888887554333 7888875 4456667788888887764213432211111 1112333445555421 35 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +++|++.. +..+..+++++++.|+. T Consensus 192 ~d~i~~~~-~~~a~~~~~~l~~~g~~ 216 (306) T 2VK2_A 192 ICMVYAHN-DDMVIGAIQAIKEAGLK 216 (306) T ss_dssp CCEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CCEEEECC-HHHHHHHHHHHHHCCCC Confidence 77887664 44567788888887764 No 192 >1JFT_A PURINE NUCLEOTIDE SYNTHESIS REPRESSOR/DNA Complex; TRANSCRIPTION REGULATION, DNA-BINDING, REPRESSOR, PURINE; HET: HPA; 2.5A {Escherichia coli} SCOP: c.93.1.1, a.35.1.5 Probab=97.28 E-value=3.2e-07 Score=94.53 Aligned_cols=206 Identities=14% Similarity=0.133 Sum_probs=119.1 Template_Neff=11.700 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...+.++||++.|..+. .++.....+++.++++.| +++.+.++..+. +...+.+ T Consensus 54 ~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~----~~~~~~~ 107 (340) T 1JFT_A 54 KVNHTKSIGLLATSSEA------------AYFAEIIEAVEKNCFQKG----------YTLILGNAWNNL----EKQRAYL 107 (340) T ss_dssp HHTCCCEEEEEESCSCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHH T ss_pred ccCCCCEEEEEeCCCCc------------chHHHHHHHHHHHHHHcC----------CEEEEEeCCCCH----HHHHHHH Confidence 34578899999987542 255677788888877653 233444443332 2223333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILR-LFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~-~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++.. .++|++|+....... .....+. ..++|+|..+...+. .++.+.+..++ T Consensus 108 ~~~~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~~~ 161 (340) T 1JFT_A 108 SMMAQ-------------------KRVDGLLVMCSEYPE-PLLAMLEEYRHIPMVVMDAGEAK------ADFTDAVIDNA 161 (340) T ss_dssp HHHHH-------------------TTCSEEEECCSCCCH-HHHHHHHTTTTSCEEESSCSSCC------CSSSEEEECCH T ss_pred HHHHh-------------------cCCCEEEEeCCCCCH-HHHHHHHHhcCCCEEEEcCCccC------CCCCcEEEeCH Confidence 43332 478888875443222 2233333 479999987764431 23445666666 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNAR 276 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~ 276 (908) ...++.+++++.+.++++++++.. +..++..+.++|++.+++. ++.+........+.+..+....++++++ ..++| T Consensus 162 ~~~~~~~~~~l~~~g~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~d 240 (340) T 1JFT_A 162 FEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEA-MIKVPESWIVQGDFEPESGYRAMQQILSQPHRPT 240 (340) T ss_dssp HHHHHHHHHHHHHHTCCCEEEECCCTTSCCCCCHHHHHHHHHHHH-TCCCCGGGBCCCCSSHHHHHHHHHHHHTSSSCCS T ss_pred HHHHHHHHHHHHHCCCCeEEEEeCCccccchHHHHHHHHHHHHHC-CCCCCHHHeeecCCChHHHHHHHHHHHcCCCCCC Confidence 667778888876668889999985 3345667788888888765 3444321111100111233344555542 12477 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +|++.. +..+..+++++++.|+. T Consensus 241 ~i~~~~-~~~~~~~~~~l~~~g~~ 263 (340) T 1JFT_A 241 AVFCGG-DIMAMGALCAADEMGLR 263 (340) T ss_dssp EEEESS-HHHHHHHHHHHHHTTCC T ss_pred EEEECC-HHHHHHHHHHHHHcCCC Confidence 777664 34456777788777763 No 193 >3BRS_B Periplasmic binding protein/LacI transcriptional regulator; STRUCTURAL GENOMICS, PROTEIN STRUCTURE INITIATIVE; 2.0A {Clostridium phytofermentans} Probab=97.28 E-value=3.3e-07 Score=91.85 Aligned_cols=215 Identities=11% Similarity=-0.043 Sum_probs=121.6 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||++.+.++.. ..++.....+++.++++.+ +++.+...|...+. +...+.+++ T Consensus 3 ~~~~~i~~~~~~~g~~----------~~~~~~~~~g~~~a~~~~g--------~~~~~~~~~~~~~~----~~~~~~~~~ 60 (289) T 3BRS_B 3 LKQYYMICIPKVLDDS----------SDFWSVLVEGAQMAAKEYE--------IKLEFMAPEKEEDY----LVQNELIEE 60 (289) T ss_dssp --CCEEEEECSCCCSS----------CHHHHHHHHHHHHHHHHHT--------CEEEECCCSSTTCH----HHHHHHHHH T ss_pred CcceEEEEeecCCCCC----------ChHHHHHHHHHHHHHHHhC--------CEEEEECCCCCCCH----HHHHHHHHH Confidence 4578899988875432 1355677888888888763 44555544432222 122333444 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. .+++++|+...+.. .......+...++|+|......+. .++.+++.++... T Consensus 61 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~~ 115 (289) T 3BRS_B 61 AIK-------------------RKPDVILLAAADYEKTYDAAKEIKDAGIKLIVIDSGMKQ------DIADITVATDNIQ 115 (289) T ss_dssp HHH-------------------TCCSEEEECCSCTTTTHHHHTTSGGGTCEEEEESCCCSS------CCCSEEEECCHHH T ss_pred HHH-------------------hCCCEEEEcCCChHhhHHHHHHHHHCCCEEEEECCCCCc------ccccEEEEcCHHH Confidence 332 47887776544332 224445566789999987654321 2456677777777 Q NP_000836.2 202 QAQAMVDIVTALG--WNYVSTLASE--GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNAR 276 (908) Q Consensus 202 ~~~~~~~~l~~~~--~~~v~ii~~~--~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~ 276 (908) .++.+++++.+.+ .++++++... ..++..+.+++++.+++. ++.+....... .+..+....++++++ ..+++ T Consensus 116 ~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~ 192 (289) T 3BRS_B 116 AGIRIGAVTKNLVRKSGKIGVISFVKNSKTAMDREEGLKIGLSDD-SNKIEAIYYCD--SNYDKAYDGTVELLTKYPDIS 192 (289) T ss_dssp HHHHHHHHHHHHTSSSCEEEEEESCTTSHHHHHHHHHHHHHHGGG-GGGEEEEEECT--TCHHHHHHHHHHHHHHCTTEE T ss_pred HHHHHHHHHHHHhcCCceEEEEEccCCChHHHHHHHHHHHHHhcC-CCcEEEEEecC--CCHHHHHHHHHHHHHHCCCce Confidence 7777877775544 6789988733 335666778888887764 34443211111 111223334455542 12467 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++.. +..+..+++++++.|...++.+++. T Consensus 193 ~i~~~~-~~~a~~~~~~~~~~g~~~~~~i~~~ 223 (289) T 3BRS_B 193 VMVGLN-QYSATGAARAIKDMSLEAKVKLVCI 223 (289) T ss_dssp EEEESS-HHHHHHHHHHHHHTTCTTTCEEEEE T ss_pred EEEECC-hhhHHHHHHHHHHCCCcCCeEEEEE Confidence 776553 4445667777777776323444443 No 194 >4RK4_A Transcriptional regulator, LacI family; sugar binding, transcription regulation, Enzyme; HET: GLC; 1.32A {Lactobacillus casei ATCC 334} Probab=97.27 E-value=3.4e-07 Score=91.30 Aligned_cols=205 Identities=15% Similarity=0.126 Sum_probs=115.7 Template_Neff=12.200 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++.++||+++|..+. .++..+..+++.++++.+ +++.+.+...+. +...+.+ T Consensus 5 ~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~ 58 (283) T 4RK4_A 5 RAQATGNIGVLVSRVTN------------PFFAGLFDAIERELHAHG----------YQVMITQTYDDP----EAEERFL 58 (283) T ss_dssp ----CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHH T ss_pred ccCCCCeEEEEEccCCC------------hhHHHHHHHHHHHHHHCC----------CEEEEEcCCCCH----HHHHHHH Confidence 34568999999997542 255667778877776542 334444443332 2233344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++.. .++|++|+...+... .....++..++|++..+...+. +..+.+..++. T Consensus 59 ~~l~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~~pvv~~~~~~~~-------~~~~~v~~d~~ 111 (283) T 4RK4_A 59 KQLKS-------------------RELDGVILASVEAPD-RVMAVAKAFPGRVVVVNADVQI-------PGATSLVLPHY 111 (283) T ss_dssp HHHHT-------------------TSSSEEEESCCSCHH-HHHHHHHHSTTSEEEESSSCCC-------TTSEEECCCHH T ss_pred HHHHh-------------------CCCCEEEEecCCCCH-HHHHHHHhCCCcEEEEcCCCCC-------CCCcEEEeChH Confidence 44332 478888875544333 3334556678998887654321 23455666666 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGN----YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE---TP 273 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~----~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~---~~ 273 (908) ..++.+++++.+.+.++++++..+.. .+..+.++|++.+++. ++.+..........+..+....+++++. .. T Consensus 112 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 190 (283) T 4RK4_A 112 QATRDALDYLFNQGHRRFAYVSGGTISGAHHGQSRTQAFLDFMQAH-QLLVAQDLLFGQIHTAKEGQAVGKQLASLAPNV 190 (283) T ss_dssp HHHHHHHHHHHHTTCCSEEEECSSCTTSSCTTHHHHHHHHHHHHHT-TCCCCGGGEECSCCSHHHHHHHHHHHHTSCTTT T ss_pred HHHHHHHHHHHHCCCCeEEEEeCCCCCCCcchHHHHHHHHHHHHHC-CCccchhHccCCCCChhHHHHHHHHHHHhCccC Confidence 67777888877668889999885432 4556777888877764 3433221111100011122333344431 13 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++|+|++.. +..+..+++++++.|+. T Consensus 191 ~~~~i~~~~-~~~a~~~~~al~~~g~~ 216 (283) T 4RK4_A 191 RPDAVFTNS-DEVAVGVIDSLLAADVK 216 (283) T ss_dssp SCSEEECSC-HHHHHHHHHHHHHTTCC T ss_pred CCCEEEECC-HHHHHHHHHHHHHCCCC Confidence 678887664 44566788888887764 No 195 >4RK5_A Transcriptional regulator, LacI family; sugar binding, transcription regulation, Enzyme; HET: SUC; 1.35A {Lactobacillus casei ATCC 334} Probab=97.27 E-value=3.4e-07 Score=91.30 Aligned_cols=205 Identities=15% Similarity=0.126 Sum_probs=115.7 Template_Neff=12.200 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++.++||+++|..+. .++..+..+++.++++.+ +++.+.+...+. +...+.+ T Consensus 5 ~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~ 58 (283) T 4RK5_A 5 RAQATGNIGVLVSRVTN------------PFFAGLFDAIERELHAHG----------YQVMITQTYDDP----EAEERFL 58 (283) T ss_dssp ----CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHH T ss_pred ccCCCCeEEEEEccCCC------------hhHHHHHHHHHHHHHHCC----------CEEEEEcCCCCH----HHHHHHH Confidence 34568999999997542 255667778877776542 334444443332 2233344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++.. .++|++|+...+... .....++..++|++..+...+. +..+.+..++. T Consensus 59 ~~l~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~~pvv~~~~~~~~-------~~~~~v~~d~~ 111 (283) T 4RK5_A 59 KQLKS-------------------RELDGVILASVEAPD-RVMAVAKAFPGRVVVVNADVQI-------PGATSLVLPHY 111 (283) T ss_dssp HHHHT-------------------TSCSEEEESSCSCHH-HHHHHHHHSTTSEEEESSSCCC-------TTSEEECCCHH T ss_pred HHHHh-------------------CCCCEEEEecCCCCH-HHHHHHHhCCCcEEEEcCCCCC-------CCCcEEEeChH Confidence 44332 478888875544333 3334556678998887654321 23455666666 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGN----YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE---TP 273 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~----~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~---~~ 273 (908) ..++.+++++.+.+.++++++..+.. .+..+.++|++.+++. ++.+..........+..+....+++++. .. T Consensus 112 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 190 (283) T 4RK5_A 112 QATRDALDYLFNQGHRRFAYVSGGTISGAHHGQSRTQAFLDFMQAH-QLLVAQDLLFGQIHTAKEGQAVGKQLASLAPNV 190 (283) T ss_dssp HHHHHHHHHHHHTTCCSEEEECSSCTTSSCTTHHHHHHHHHHHHHT-TCCCCGGGEECSCCSHHHHHHHHHHHHTSCTTT T ss_pred HHHHHHHHHHHHCCCCeEEEEeCCCCCCCcchHHHHHHHHHHHHHC-CCccchhHccCCCCChhHHHHHHHHHHHhCccC Confidence 67777888877668889999885432 4556777888877764 3433221111100011122333344431 13 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++|+|++.. +..+..+++++++.|+. T Consensus 191 ~~~~i~~~~-~~~a~~~~~al~~~g~~ 216 (283) T 4RK5_A 191 RPDAVFTNS-DEVAVGVIDSLLAADVK 216 (283) T ss_dssp SCSEEECSC-HHHHHHHHHHHHHTTCC T ss_pred CCCEEEECC-HHHHHHHHHHHHHCCCC Confidence 678887664 44566788888887764 No 196 >2QU7_B Putative transcriptional regulator; STRUCTURAL GENOMICS, TRANSCRIPTION, PSI-2, Protein; 2.3A {Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305} Probab=97.26 E-value=3.6e-07 Score=91.52 Aligned_cols=200 Identities=12% Similarity=0.073 Sum_probs=119.6 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|... .++.....+++.++++.| +++.+.++..++. ...+.++ T Consensus 5 ~~~~~~I~~~~~~~~-------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~~----~~~~~~~ 57 (288) T 2QU7_B 5 TGRSNIIAFIVPDQN-------------PFFTEVLTEISHECQKHH----------LHVAVASSEENED----KQQDLIE 57 (288) T ss_dssp --CEEEEEEEESSCC-------------HHHHHHHHHHHHHHGGGT----------CEEEEEECTTCHH----HHHHHHH T ss_pred CCCCCEEEEEecCCC-------------hHHHHHHHHHHHHHHHCC----------CEEEEEeCCCCHH----HHHHHHH Confidence 456889999999742 245677788888877653 2334444433321 2223344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. ++++++|+...+.... ..+...++|+|..+...+ .++.+++..++.. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~~~---~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~~ 108 (288) T 2QU7_B 58 TFVS-------------------QNVSAIILVPVKSKFQ---MKREWLKIPIMTLDRELE-------STSLPSITVDNEE 108 (288) T ss_dssp HHHH-------------------TTEEEEEECCSSSSCC---CCGGGTTSCEEEESSCCT-------TCCCCEEEECHHH T ss_pred HHHH-------------------CCCCEEEEecCCcchh---hhHHhcCCCEEEeCCCCC-------CCCCCEEEeChHH Confidence 3332 4788888765443322 234677999988765432 1345677777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPRE------PRPGEFEKIIKRLLETP 273 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~------~~~~~~~~~~~~l~~~~ 273 (908) .++.+++++.+.+.++++++..+. .++..+.+++++.+++. ++.+.....+... .+..+....+++++. . T Consensus 109 ~~~~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~ 186 (288) T 2QU7_B 109 AAYIATKRVLESTCKEVGLLLANPNISTTIGRKNGYNKAISEF-DLNVNPSLIHYSDQQLGTNAQIYSGYEATKTLLS-K 186 (288) T ss_dssp HHHHHHHHHHTTTCCSEEEEECCTTSHHHHHHHHHHHHHHHHT-TCCCCGGGEEECCSSCSHHHHHHHHHHHHHHHHH-T T ss_pred HHHHHHHHHHHcCCCcEEEEecCCCCcchHHHHHHHHHHHHHC-CCCCCcccEEeecCCCCCchhHHHHHHHHHHHHh-c Confidence 788888888777888999998543 35667788888888765 3433211111000 011223344555553 4 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++|+|++.. +..+..+++++++.|+. T Consensus 187 ~~d~i~~~~-~~~a~~~~~~l~~~g~~ 212 (288) T 2QU7_B 187 GIKGIVATN-HLLLLGALQAIKESEKE 212 (288) T ss_dssp TCCEEEECS-HHHHHHHHHHHHHSSCC T ss_pred CCCEEEEcC-cHHHHHHHHHHHHcCCC Confidence 788887764 44567788888877763 No 197 >4IRX_B Sugar ABC transporter, periplasmic sugar-binding; ABC transporter, periplasmic binding protein; HET: INS, MSE; 1.451A {Caulobacter crescentus} Probab=97.26 E-value=3.7e-07 Score=91.76 Aligned_cols=208 Identities=13% Similarity=0.057 Sum_probs=119.3 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++.++||++.|..+. .++.....+++.++++.+ +++.+.|+..++. ...+.+ T Consensus 4 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~l~~~~~~~~~~----~~~~~~ 57 (296) T 4IRX_B 4 PRGSHMEVVVSFNDLSQ------------PFFVAMRRELEDEAAKLG----------VKVQVLDAQNNSS----KQISDL 57 (296) T ss_dssp CCCSSCEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCHH----HHHHHH T ss_pred CCCCCcEEEEEeCCCCC------------HHHHHHHHHHHHHHHHcC----------CEEEEEeCCCCHH----HHHHHH Confidence 45578999999986532 255677788888887753 3344555543322 223334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIG-AAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg-~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++++. +++++++. +..+.........+...++|+|..+...+. ..++++++.+++ T Consensus 58 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~d~ 113 (296) T 4IRX_B 58 QAAAV-------------------QGAKVVIVAPTDSKALAGAADDLVEQGVAVISVDRNIAG-----GKTAVPHVGADN 113 (296) T ss_dssp HHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCEEEEESSCCCS-----SSSCCCEEEECH T ss_pred HHHHH-------------------CCCCEEEEecCChhhHHHHHHHHHHCCCEEEEEcCCCCC-----CCceeeEEecCh Confidence 43332 46776654 333332224445566789999987764331 134567777887 Q NP_000836.2 200 SYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE---T 272 (908) Q Consensus 200 ~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~---~ 272 (908) ...++.+++++.+. +.++++++.. ++.++..+.+++++.+++. +..+..........+..+....+++++. . T Consensus 114 ~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~ 192 (296) T 4IRX_B 114 VAGGRAMADWVVKTYPAGARVVVITNDPGSSSSIERVKGVHDGLAAG-GPAFKIVTEQTANSKRDQALTVTQNILTSMRD 192 (296) T ss_dssp HHHHHHHHHHHHHHCTTCEEEEEEESCTTSHHHHHHHHHHHHHHHHH-CTTEEEEEEEECTTCHHHHHHHHHHHHHHTTT T ss_pred HHHHHHHHHHHHHHCCCCCEEEEEEcCCCCchHHHHHHHHHHHHHcc-CCCcEEEeeecCCCCHHHHHHHHHHHHHhCCC Confidence 77788888887654 5678998875 3345666777888877764 2332211111000111122233333331 1 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) .++++|++.. +..+..+++++++.|+. T Consensus 193 ~~~~~i~~~~-~~~a~~~~~~l~~~g~~ 219 (296) T 4IRX_B 193 TPPDVILCLN-DDMAMGALEAVRAAGLD 219 (296) T ss_dssp SCCSEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CCCCEEEEcC-ChhHHHHHHHHHHCCCC Confidence 3577776664 34466778888877763 No 198 >4RY9_A Periplasmic binding protein/LacI transcriptional regulator; SUGAR TRANSPORTER, ENZYME FUNCTION INITIATIVE; HET: GOL, TLZ; 1.4A {Verminephrobacter eiseniae EF01-2} Probab=97.25 E-value=3.9e-07 Score=91.91 Aligned_cols=205 Identities=13% Similarity=0.041 Sum_probs=116.9 Template_Neff=12.100 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++..+..+++.++++.+ +++.+.++..++. ...+.++ T Consensus 4 ~~~~~~Ig~v~~~~~~------------~~~~~~~~~~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~ 57 (302) T 4RY9_A 4 QTGAFKIGVSMKTLSA------------PYFAAQMEAAKARGKELG----------YEVLATDAQGKLQ----KQISDVE 57 (302) T ss_dssp --CCCEEEEEESCCCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCHH----HHHHHHH T ss_pred cCCCeEEEEEECCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCHH----HHHHHHH Confidence 3567899999987542 245567777777776632 3444555443321 2223334 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. .+++++|+...+.... .....+...++|+|..+...+. ..++++++.+++. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~~~~ 113 (302) T 4RY9_A 58 DLVT-------------------RGVKLLIINPADSEGLVNAVNNASANGVKVVVIDSTLNP-----RANFVTQVQSSNS 113 (302) T ss_dssp HHHH-------------------TTEEEEEEECSCTTTTHHHHHHHHHTTCEEEEESSCCCT-----TSCCSEEEECCHH T ss_pred HHHH-------------------CCCCEEEEecCCcccHHHHHHHHHHCCCEEEEECCCCCC-----cccceEEEecChh Confidence 3332 4788777654443322 3445566789999987754331 1345667777777 Q NP_000836.2 201 YQAQAMVDIVTA-L--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVC--------IAQSQKIPREPRPGEFEKIIK 267 (908) Q Consensus 201 ~~~~~~~~~l~~-~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~--------v~~~~~~~~~~~~~~~~~~~~ 267 (908) ..+..+++++.+ . +.++++++.. ++.++..+.+++++.+++. ++. +....... .+..+....++ T Consensus 114 ~~~~~~~~~l~~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~ 190 (302) T 4RY9_A 114 INGALVGHWVIEEVGNKSLKIALLSGEKGNPVGQERRLGVLSGIIEA-QLRKFGKADLTVVGQGWGH--WNDEGGLKAME 190 (302) T ss_dssp HHHHHHHHHHHHHHTTCCCEEEEEECCTTCHHHHHHHHHHHHHHHHH-HHHHHSCCCCEEEEEEECT--TSHHHHHHHHH T ss_pred HhHHHHHHHHHHHhCCCccEEEEEEcCCCChHHHHHHHHHHHHHHHH-HHHHhCCCCEEEEeeeecC--CCHHHHHHHHH Confidence 777788887754 2 3578999985 3445666777788777664 232 21111111 11123444455 Q NP_000836.2 268 RLLET-PNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 268 ~l~~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +++.. .++++|++.. +..+..+++++++.|+. T Consensus 191 ~~~~~~~~~~~i~~~~-~~~a~~~~~~~~~~g~~ 223 (302) T 4RY9_A 191 DLLVANKDINMVLGEN-DSMVLGARRAIESAGRT 223 (302) T ss_dssp HHHHHCSCCCEEEESS-HHHHHHHHHHHHHHTCC T ss_pred HHHHhCCCCCEEEeCC-hHHHHHHHHHHHHcCCC Confidence 55421 2466666553 44566778888877764 No 199 >3G1W_A Sugar ABC transporter; Sugar ABC transporter, Sugar-binding protein; 2.02A {Bacillus halodurans C-125} Probab=97.24 E-value=4e-07 Score=92.08 Aligned_cols=213 Identities=14% Similarity=0.059 Sum_probs=117.4 Template_Neff=11.700 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILD-TCSRDTYALEQSLTFVQ 121 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d-~~~~~~~a~~~~~~~~~ 121 (908) .++++||++.|.... .++.....+++.++++.+ + ++.+.+ +..++ +...+.++ T Consensus 2 ~~~~~Igvl~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~~----~~~~~~~~ 55 (305) T 3G1W_A 2 SLNETYMMITFQSGM------------DYWKRCLKGFEDAAQALN--------V--TVEYRGAAQYDI----QEQITVLE 55 (305) T ss_dssp ---CEEEEEESSTTS------------THHHHHHHHHHHHHHHHT--------C--EEEEEECSSSCH----HHHHHHHH T ss_pred CCCeEEEEEecCCCC------------hHHHHHHHHHHHHHHHcC--------C--EEEEecccCCCH----HHHHHHHH Confidence 357899999997632 245567778887777642 3 333444 32222 12223333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. ++++++|+...+... ......+...++|+|..+...+. .++++++.++.. T Consensus 56 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 110 (305) T 3G1W_A 56 QAIA-------------------KNPAGIAISAIDPVELTDTINKAVDAGIPIVLFDSGAPD------SHAHSFLGTNNY 110 (305) T ss_dssp HHHH-------------------HCCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCTT------SCCSCEEECCHH T ss_pred HHHH-------------------cCCCEEEEeCCCHHHHHHHHHHHHHCCCCEEEEcCCCCC------ccccEEEeCCHH Confidence 3332 467877764433322 23445566779999987654321 245667777777 Q NP_000836.2 201 YQAQAMVDIVTAL--GWNYVSTLASEG-NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~--~~~~v~ii~~~~-~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ..+..+++++.+. +.++++++.... .....+.+++++.+++. +..+..........+..+....++++++. .++| T Consensus 111 ~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d 189 (305) T 3G1W_A 111 NAGMNAAYKMAELLDGEGEVAVITLPNQLNHQERTTGFKETLEAE-FPAIEVIAVEDGRGDSLHSRRVAHQLLEDYPNLA 189 (305) T ss_dssp HHHHHHHHHHHHHTTTCEEEEEEECTTCHHHHHHHHHHHHHHHHH-CTTEEEEEEEECTTCHHHHHHHHHHHHHHCTTEE T ss_pred HHHHHHHHHHHHHcCCCcEEEEEECCCcccHHHHHHHHHHHHHHH-CCCeEEEEEecCCCChHHHHHHHHHHHHHCCCcc Confidence 7777888887655 778999998532 45566777888877654 23222111111001112334445555421 2477 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++.. +..+..+++++++.+...++.+++. T Consensus 190 ~i~~~~-~~~a~~~~~~l~~~~~~~~v~ii~~ 220 (305) T 3G1W_A 190 GIFATE-ANGGVGVGDAVRLESRAGEIQIISF 220 (305) T ss_dssp EEEESS-HHHHHHHHHHHHHTTCTTTSEEEEE T ss_pred EEEEec-CCcchHHHHHHHHccCCCCEEEEEE Confidence 787664 3455667777777664323444443 No 200 >3G1W_B Sugar ABC transporter; Sugar ABC transporter, Sugar-binding protein; HET: MSE; 2.02A {Bacillus halodurans C-125} Probab=97.24 E-value=4e-07 Score=92.08 Aligned_cols=213 Identities=14% Similarity=0.059 Sum_probs=118.2 Template_Neff=11.700 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILD-TCSRDTYALEQSLTFVQ 121 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d-~~~~~~~a~~~~~~~~~ 121 (908) .++++||++.|.... .++.....+++.++++.+ + ++.+.+ +..++ +...+.++ T Consensus 2 ~~~~~Igvl~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~~----~~~~~~~~ 55 (305) T 3G1W_B 2 SLNETYMMITFQSGM------------DYWKRCLKGFEDAAQALN--------V--TVEYRGAAQYDI----QEQITVLE 55 (305) T ss_dssp --CCEEEEEEESTTS------------THHHHHHHHHHHHHHHHT--------C--EEEEEEESSSCH----HHHHHHHH T ss_pred CCCeEEEEEecCCCC------------hHHHHHHHHHHHHHHHcC--------C--EEEEecccCCCH----HHHHHHHH Confidence 357899999997632 245567778887777642 3 333444 32222 12223333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. ++++++|+...+... ......+...++|+|..+...+. .++++++.++.. T Consensus 56 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 110 (305) T 3G1W_B 56 QAIA-------------------KNPAGIAISAIDPVELTDTINKAVDAGIPIVLFDSGAPD------SHAHSFLGTNNY 110 (305) T ss_dssp HHHH-------------------HCCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCTT------SCCSCEEECCHH T ss_pred HHHH-------------------cCCCEEEEeCCCHHHHHHHHHHHHHCCCCEEEEcCCCCC------ccccEEEeCCHH Confidence 3332 467877764433322 23445566779999987654321 245667777777 Q NP_000836.2 201 YQAQAMVDIVTAL--GWNYVSTLASEG-NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~--~~~~v~ii~~~~-~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ..+..+++++.+. +.++++++.... .....+.+++++.+++. +..+..........+..+....++++++. .++| T Consensus 111 ~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d 189 (305) T 3G1W_B 111 NAGMNAAYKMAELLDGEGEVAVITLPNQLNHQERTTGFKETLEAE-FPAIEVIAVEDGRGDSLHSRRVAHQLLEDYPNLA 189 (305) T ss_dssp HHHHHHHHHHHHHTTTCEEEEEEECTTCHHHHHHHHHHHHHHHHH-CTTEEEEEEEECTTCHHHHHHHHHHHHHHCTTEE T ss_pred HHHHHHHHHHHHHcCCCcEEEEEECCCcccHHHHHHHHHHHHHHH-CCCeEEEEEecCCCChHHHHHHHHHHHHHCCCcc Confidence 7777888887655 778999998532 45566777888877654 23222111111001112334445555421 2477 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++.. +..+..+++++++.+...++.+++. T Consensus 190 ~i~~~~-~~~a~~~~~~l~~~~~~~~v~ii~~ 220 (305) T 3G1W_B 190 GIFATE-ANGGVGVGDAVRLESRAGEIQIISF 220 (305) T ss_dssp EEEESS-HHHHHHHHHHHHHTTCTTTSEEEEE T ss_pred EEEEec-CCcchHHHHHHHHccCCCCEEEEEE Confidence 787664 3455667777777664323444443 No 201 >5XSD_B Periplasmic binding protein/LacI transcriptional regulator; Two component system, histidine kinase; 2.5A {Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)} Probab=97.23 E-value=4.3e-07 Score=91.87 Aligned_cols=217 Identities=17% Similarity=0.071 Sum_probs=121.3 Template_Neff=11.900 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ......++||++.|..+. .++..+..+++.++++.+ +++.+...+. .++ +...+. T Consensus 13 ~~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~~~~~~ 67 (306) T 5XSD_B 13 EKEPIKPKIVLISHIKTN------------PYWLDIKAGAERAAKERG--------AVVEFLGPTT-AST----EDGLKL 67 (306) T ss_dssp ---CCCCEEEEECSCSSC------------HHHHHHHHHHHHHHHHHT--------CEEEEECCSS-CCH----HHHHHH T ss_pred cCCCCCCeEEEEecCCCC------------HHHHHHHHHHHHHHHHcC--------CEEEEeCCCC-CCH----HHHHHH Confidence 345578999999986542 255677888888887753 3444433222 221 122233 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVI-GAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) ++++.. .++|++| ++..+.........+...++|+|..+...+. .++++++.++ T Consensus 68 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d 122 (306) T 5XSD_B 68 FDMATS-------------------AKVSGIITYVQEEGQYKKKINSAMEKGIPVVTIASDEED------SNRIAYVGTD 122 (306) T ss_dssp HHHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCCS------SCCSEEEEEC T ss_pred HHHHHh-------------------CCCCEEEEeCCChhHHHHHHHHHHHCCCCEEEEcCCCCC------cCCeEEEecC Confidence 333332 4778777 4433332223445566789999987654321 2456677777 Q NP_000836.2 199 DSYQAQAMVDIVTAL-GW-NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-P 273 (908) Q Consensus 199 ~~~~~~~~~~~l~~~-~~-~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~ 273 (908) ....+..+++++.+. +. ++++++.. ++.++..+.++|++.+++.+.+.+....... .+..+....+++++.. . T Consensus 123 ~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 200 (306) T 5XSD_B 123 NVLAGQVAGKEMVKQIGTSGNVAIVMGGKNVKNQKERVEGFTQYIKSNSNLKIVDTDSSD--AMLLEAEIITRKILNRND 200 (306) T ss_dssp HHHHHHHHHHHHHHHHCSSSEEEEECSCTTCHHHHHHHHHHHHHHHHHCCCEEECCCCTT--TTTCCHHHHHHHHHHHCT T ss_pred HHHHHHHHHHHHHHHHCCCceEEEEECCCCcccHHHHHHHHHHHHHhcCCcEEeeeecCc--hhHHHHHHHHHHHHHhCC Confidence 777777888887654 65 88998875 3345667778888877764213332211111 1112233445555421 2 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSD 309 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~ 309 (908) ++++|++.. +..+..+++++++.|+..++.+++.+ T Consensus 201 ~~~~i~~~~-~~~a~~~~~~~~~~g~~~~~~vi~~~ 235 (306) T 5XSD_B 201 NINALFCTS-ALDGIGAARAVKDLNYKDRVKIICFD 235 (306) T ss_dssp TCCEEEESS-HHHHHHHHHHHHHTTCBTTBEEEEES T ss_pred CCCEEEECC-cchHHHHHHHHHHcCCCCCeEEEEeC Confidence 467776654 44566777777777763234444443 No 202 >5DKV_A ABC transporter substrate binding protein; Solute Binding Protein, ENZYME FUNCTION; HET: T6T; 1.68A {Agrobacterium vitis (strain S4 / ATCC BAA-846)} Probab=97.23 E-value=4.3e-07 Score=92.85 Aligned_cols=219 Identities=10% Similarity=0.013 Sum_probs=124.2 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDT-CSRDTYALEQSLTFV 120 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~-~~~~~~a~~~~~~~~ 120 (908) .++.++||++.|..+. ..+.....+++.++++.| + ++.+.+. ..++ +...+.+ T Consensus 24 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~l~~~~~~~~~~----~~~~~~~ 77 (324) T 5DKV_A 24 ENKKFRIALIPGLTTD------------AFYITMHKGAEAAAAAIG--------A--QIIFQGAPDFNP----VTQVPVL 77 (324) T ss_dssp SSCCCEEEEECSCSSC------------HHHHHHHHHHHHHHHHHT--------C--EEEECCCSSSCH----HHHHHHH T ss_pred cCCCcEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC--------C--EEEEeCCCCCCH----HHHHHHH Confidence 3468999999887542 245677788888887753 2 3333433 2222 2233344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELS----DNTRYDFFSRV 195 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~----~~~~~~~~~~~ 195 (908) ++++. ++++++|+...+... ......+...++|+|..+...+... .....++++++ T Consensus 78 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~~~~~~~~~~~~~~v 138 (324) T 5DKV_A 78 DAVIA-------------------KKPDAILIAPTDTTQLVQPLKKAADAGIPMITVDTFIGTGDYQTGAGDGDFPLSYI 138 (324) T ss_dssp HHHHT-------------------TCCSEEEECCSCTTTTHHHHHHHHHTTCCEEEESSCSTTSCCSSSCSTTCCSSCEE T ss_pred HHHHH-------------------hCCCEEEECCCCchHhHHHHHHHHHCCCCEEEEcCCCCCCcccCCCCCCCCCcEEE Confidence 44332 467877764433322 2444556678999998775433100 00013456777 Q NP_000836.2 196 VPPDSYQAQAMVDIVT-ALGWNYVSTLAS---EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~-~~~~~~v~ii~~---~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) .++....++.+++++. +.+.++++++.. ++.++..+.++|++.+++..++.+....... .+..+....+++++. T Consensus 139 ~~d~~~~~~~~~~~l~~~~~~~~~~~i~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~ 216 (324) T 5DKV_A 139 ASDNVLGGEIAARSLALAIGDKGKVYVSNVKPGVSTTDQREQGFKSEMAKHPGITVLETQFND--NDANKAASQLQAVYA 216 (324) T ss_dssp EECHHHHHHHHHHHHHHHTTTCEEEEEEESCTTCHHHHHHHHHHHHHHTTCTTEEECCCEECT--TCHHHHHHHHHHHHH T ss_pred ecCHHHHHHHHHHHHHHHHCCCceEEEEEcCCCCChHHHHHHHHHHHHhhCCCcEEEEeeeCC--CCHHHHHHHHHHHHH Confidence 7887777888888874 667788888875 3345667778888877654124433221111 112234445555543 Q NP_000836.2 272 T-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 272 ~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) . .++++|++.. +..+..+++++++.|...++.+++. T Consensus 217 ~~~~~~~i~~~~-~~~a~~~~~al~~~g~~~~i~i~~~ 253 (324) T 5DKV_A 217 RNPDLAGVFGAN-LFSGLGSANGVQQAGQSGTIKVVAF 253 (324) T ss_dssp HCTTCCEEEECS-HHHHHHHHHHHHHTTCBTTBEEEEE T ss_pred HCCCccEEEEcC-cchhHHHHHHHHHcCCCCceEEEEe Confidence 1 2467776654 4456678888887776323444443 No 203 >1ZVV_B Glucose-resistance amylase regulator/HPr-like protein crh/DNA; ccpa crh dna; HET: SEP, IOD; 2.98A {Bacillus subtilis} SCOP: c.93.1.1, a.35.1.5 Probab=97.23 E-value=4.3e-07 Score=93.15 Aligned_cols=204 Identities=11% Similarity=0.116 Sum_probs=120.1 Template_Neff=11.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++..+..+++.++++.+ + ++.+.+...++ +...+.++ T Consensus 57 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~~ 110 (332) T 1ZVV_B 57 SKKTTTVGVIIPDISN------------IFYAELARGIEDIASMYK--------Y--NIILSNSDQNQ----DKQLHLLN 110 (332) T ss_dssp HTCCSEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------C--EEEEEECTTCH----HHHHHHHH T ss_pred cCCCCEEEEEeCCCCC------------hHHHHHHHHHHHHHHHcC--------C--eEEEEeCCCCH----HHHHHHHH Confidence 4568899999987542 245667778887777642 2 33444443332 12223344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+. .......+...++|+|..+...+ .+..+.+.++... T Consensus 111 ~l~~-------------------~~~d~ii~~~~~~-~~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 163 (332) T 1ZVV_B 111 NMLG-------------------KQVDGIIFMSGNV-TEEHVEELKKSPVPVVLAASIES-------TNQIPSVTIDYEQ 163 (332) T ss_dssp HHHH-------------------HTCSEEEECCSCC-CHHHHHHHTTCSSCEEEESCCCT-------TCCSCEECCCHHH T ss_pred HHHh-------------------CCCCEEEEeCCCC-CHHHHHHHHhCCCCEEEECCCCC-------CCCCCEEEeCHHH Confidence 4332 4788888754443 23445556678999998765322 1345566667767 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) .+..+++++.+.+.+++++++.+.. .+..+.+++++.+++. ++.+.....+..+.+..+....+++++. ..++|+ T Consensus 164 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 242 (332) T 1ZVV_B 164 AAFDAVQSLIDSGHKNIAFVSGTLEEPINHAKKVKGYKRALTES-GLPVRDSYIVEGDYTYDSGIEAVEKLLEEDEKPTA 242 (332) T ss_dssp HHHHHHHHHHHTTCCCEEEECSCTTSHHHHTTHHHHHHHHHHHH-TCCCCTTSCCCCCSSHHHHHHHHHHHHSSSSCCSE T ss_pred HHHHHHHHHHHCCCCcEEEEeCCCCCcccHHHHHHHHHHHHHHc-CCCCCHHHeecCCCCHHHHHHHHHHHHhcCCCCCE Confidence 7777888876668889999985433 4567778888887764 3443221111111112234445555542 136788 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|.. T Consensus 243 i~~~~-~~~a~~~~~~l~~~g~~ 264 (332) T 1ZVV_B 243 IFVGT-DEMALGVIHGAQDRGLN 264 (332) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 87664 44556777888877763 No 204 >4KQ9_A Ribose ABC transporter, substrate binding; ABC transporter, ribose binding, PSI-Biology; HET: GOL; 1.9A {Conexibacter woesei} Probab=97.22 E-value=4.6e-07 Score=91.20 Aligned_cols=205 Identities=13% Similarity=-0.005 Sum_probs=119.4 Template_Neff=12.100 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|.... .++.....+++.++++.+ +++.+.|+..++. ...+.++ T Consensus 4 ~~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~ 57 (299) T 4KQ9_A 4 SAAGKKVVYSTFGAQI------------PFFNRIGEGAKAQATVRR----------LDFDISTSEIDPG----KQIDSID 57 (299) T ss_dssp CCTTCEEEEEEECTTC------------HHHHHHHHHHHHHHHHTT----------CEEEEEEECSSHH----HHHHHHH T ss_pred ccCceEEEEEeCCCCC------------HHHHHHHHHHHHHHHHcC----------CeEEEecCCCCHH----HHHHHHH Confidence 4568899999983221 355677788888777632 3444455444322 2233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. .+++++|+...+.... .....+...++|+|..+...+. ..++++++.+++. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~-----~~~~~~~v~~d~~ 113 (299) T 4KQ9_A 58 NAVA-------------------QQPDGLIVSPIDGSALVPTIKGAVEDGVPVILLADGLSE-----DVGQLSFVGSDFA 113 (299) T ss_dssp HHHH-------------------TCCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCSS-----CCCCSEEEECCHH T ss_pred HHHH-------------------cCCCEEEECCCCccccHHHHHHHHHCCCcEEEECCCCCC-----cccceEEEEcCHH Confidence 3332 4778777644333221 3445566789999987654321 1345677778887 Q NP_000836.2 201 YQAQAMVDIVTAL-G-WNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNA 275 (908) Q Consensus 201 ~~~~~~~~~l~~~-~-~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~ 275 (908) ..++.+++++.+. + .++++++..+. .++..+.++|++.+++. ++.+........ .+..+....+.++++ ..++ T Consensus 114 ~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~ 191 (299) T 4KQ9_A 114 EIGRLKATYIADRLGDGGTVAMVNGTRGMSFVEEQGEAAREVFEER-GIEIVDDVYTKA-ITPDEGLTATQNILTRHSDV 191 (299) T ss_dssp HHHHHHHHHHHHHCCTTCEEEEECCSTTCHHHHHHHHHHHHHHHHH-TCEEEEEECCSS-SCHHHHHHHHHHHHHHCTTC T ss_pred HHHHHHHHHHHHHhCCCcEEEEEeCCCCChHHHHHHHHHHHHHHhc-CcEEecccccCC-CCHHHHHHHHHHHHHhCCCC Confidence 7788888887654 6 68999998533 35666778888887765 344432111110 111233344555542 1356 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) ++|++.. +..+..+++++++.|+ T Consensus 192 ~~i~~~~-~~~~~~~~~~l~~~g~ 214 (299) T 4KQ9_A 192 GAIYYSG-DDGALGGIRAIAARNI 214 (299) T ss_dssp CEEEESS-HHHHHHHHHHHHHTTC T ss_pred CEEEEcC-cchHHHHHHHHHHCCC Confidence 7776654 3455667788877776 No 205 >5XSS_A Periplasmic binding protein/LacI transcriptional regulator; Two component system, histidine kinase; HET: XYP; 2.093A {Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)} Probab=97.21 E-value=4.8e-07 Score=92.12 Aligned_cols=217 Identities=16% Similarity=0.063 Sum_probs=119.7 Template_Neff=11.400 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) ....++.++||++.|..+. .++..+..+++.++++.+ +++.+...+. .++ +...+ T Consensus 22 ~~~~~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~a~~~~g--------~~~~~~~~~~-~~~----~~~~~ 76 (316) T 5XSS_A 22 VEKEPIKPKIVLISHIKTN------------PYWLDIKAGAERAAKERG--------AVVEFLGPTT-AST----EDGLK 76 (316) T ss_dssp ------CCEEEEECSSTTC------------HHHHHHHHHHHHHHHHHT--------CEEEEECCSS-CCH----HHHHH T ss_pred ccCCCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHcC--------CEEEEeCCCC-CCH----HHHHH Confidence 3456678999999986542 255677788888887753 3444433222 121 12223 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIG-AAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg-~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .++.+.. +++|++|. +............+...++|+|..+...+. .++++++.+ T Consensus 77 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~ 131 (316) T 5XSS_A 77 LFDMATS-------------------AKVSGIITYVQEEGQYKKKINSAMEKGIPVVTIDSDEED------SNRIAYVGT 131 (316) T ss_dssp HHHHHHH-------------------TTCSEEEECCCSTTSSHHHHHHHHHTTCCEEEESSCCCS------SCCSEEESB T ss_pred HHHHHHH-------------------cCCCEEEEccCCcchhHHHHHHHHHCCCCEEEEcCCCCC------CCCeEEEeC Confidence 3333332 47787774 333322223444566789999987654321 245677777 Q NP_000836.2 198 PDSYQAQAMVDIVTAL-GW-NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET- 272 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~-~~-~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~- 272 (908) +....+..+++++.+. +. ++++++.. ++.++..+.++|++.+++.+.+.+....... ....+....++++++. T Consensus 132 d~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~ 209 (316) T 5XSS_A 132 DNVLAGQVAGKEMVKQIGTSGNVAIVMGGKNVKNQKERVEGFTQYIKSNSNLKIVDTDSSD--AMLLEAEIITRKILNRN 209 (316) T ss_dssp CHHHHHHHHHHHHHHHHCSSSEEEEEESCTTCHHHHHHHHHHHHHHHHHCCCEEEEEEECT--TCHHHHHHHHHHHHHHC T ss_pred CHHHHHHHHHHHHHHHHCCCceEEEEECCCCchhHHHHHHHHHHHHHhcCCcEEeEEecCc--hHHHHHHHHHHHHHHhC Confidence 7777788888887654 65 88998875 3345667778888877764213332211111 1111233445555421 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) .++++|++.. +..+..+++++++.|+..++.+++. T Consensus 210 ~~~~~i~~~~-~~~a~~~~~al~~~g~~~~~~iig~ 244 (316) T 5XSS_A 210 DNINALFCTS-ALDGIGAARAVKDLNYKDRVKIICF 244 (316) T ss_dssp SCCCEEEECS-HHHHHHHHHHHHHTTCTTTSEEEEE T ss_pred CCcCEEEECC-chhHHHHHHHHHHcCCCCCeEEEEe Confidence 2467776654 3446677778877776323444443 No 206 >4YR7_A LuxP; PROTEIN-LIGAND COMPLEX, QUORUM SENSING, signaling; HET: A1B; 2.533A {Vibrio harveyi} Probab=97.20 E-value=5.1e-07 Score=93.23 Aligned_cols=222 Identities=11% Similarity=0.029 Sum_probs=124.2 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|..+.. ........+++.++++.+. .+.+++.+.|+..++. ...+.++ T Consensus 43 ~~~~~~Ig~i~~~~~~~-----------~~~~~~~~g~~~~~~~~g~------~~~l~~~~~d~~~~~~----~~~~~~~ 101 (345) T 4YR7_A 43 TQRPIKISVVYPGQQVS-----------DYWVRNIASFEKRLYKLNI------NYQLNQVFTRPNADIK----QQSLSLM 101 (345) T ss_dssp CSSCEEEEEEEECSCSC-----------CHHHHHHHHHHHHHHHTTC------CEEEEEEEECTTCCHH----HHHHHHH T ss_pred CCCCeEEEEEecCCCCC-----------HHHHHHHHHHHHHHHHcCC------cEEEEEeecCCCCCHH----HHHHHHH Confidence 56789999999975322 1334778888888888642 1222224455444322 2333344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRL-FKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~-~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. ++++++|+...+.........+.. .++|+|..+...+.... ...++.+++.+++. T Consensus 102 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~-~~~~~~~~v~~d~~ 161 (345) T 4YR7_A 102 EALK-------------------SKSDYLIFTLDTTRHRKFVEHVLDSTNTKLILQNITTPVREW-DKHQPFLYVGFDHA 161 (345) T ss_dssp HHHH-------------------TCCSEEEECCCTTTSHHHHHHHHTTCSSEEEEETCCSCBGGG-GGSCCSEEEECCHH T ss_pred HHHH-------------------cCCCEEEEeCCchhhHHHHHHHHHhCCCeEEEEcCCCCcchh-ccCCCeEEEEcChH Confidence 4332 478888876543333333444444 79999987654432111 11346677888888 Q NP_000836.2 201 YQAQAMVDIVTALGWN--YVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~--~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ..++.+++++.+.+.+ +++++..+ +.++..+.++|++.+++.+++++....... .+..+....+++++.. .+++ T Consensus 162 ~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~ 239 (345) T 4YR7_A 162 EGSRELATEFGKFFPKHTYYSVLYFSEGYISDVRGDTFIHQVNRDNNFELQSAYYTK--ATKQSGYDAAKASLAKHPDVD 239 (345) T ss_dssp HHHHHHHHHHHHHSCTTCEEEEECCSTTHHCCCCCCHHHHHHHHHHCCEEEEEECCC--SSHHHHHHHHHHHHHHCCCCS T ss_pred HHHHHHHHHHHHhCCCCCeEEEEEecCCchhHHHHHHHHHHHHhcCCceEeeccccC--CCHHHHHHHHHHHHHHCCCCc Confidence 8888888887654443 48888754 446667778888877653223333211111 1122344455555431 2345 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++. ++..+..+++++++.|. .++.+++. T Consensus 240 ~i~~~-~~~~a~~~~~al~~~g~-~~i~i~g~ 269 (345) T 4YR7_A 240 FIYAC-STDVALGAVDALAELGR-EDIMINGW 269 (345) T ss_dssp EEEES-SHHHHHHHHHHHHHHTC-TTSEEBCS T ss_pred EEEEC-ChHHHHHHHHHHHHcCC-CCcEEEee Confidence 55544 34455667888887776 23344443 No 207 >2IOY_A Periplasmic sugar-binding proteins; Ribose binding protein, sugar binding; HET: RIP; 1.9A {Thermoanaerobacter tengcongensis} Probab=97.19 E-value=5.3e-07 Score=89.96 Aligned_cols=208 Identities=13% Similarity=0.145 Sum_probs=116.2 Template_Neff=11.900 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIE 125 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~~ 125 (908) .+||++.|..+. .++.....+++.++++.+ +++.+.++..++. ...+.++++.. T Consensus 2 ~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~~----------~~l~~~~~~~~~~----~~~~~~~~l~~ 55 (283) T 2IOY_A 2 KTIGLVISTLNN------------PFFVTLKNGAEEKAKELG----------YKIIVEDSQNDSS----KELSNVEDLIQ 55 (283) T ss_dssp CEEEEEESCSSS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCHH----HHHHHHHHHHH T ss_pred cEEEEEecCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEECCCCCHH----HHHHHHHHHHh Confidence 578999986542 245667778877777642 3344455433322 22233333332 Q NP_000836.2 126 KDASDVKCANGDPPIFTKPDKISGVIG-AAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 126 ~~~~~~~~~~~~~~~~~~~~~v~~vIg-~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) ++++++|. +..+.........+...++|+|..+...+. .++.+++.++....++ T Consensus 56 -------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~d~~~~~~ 110 (283) T 2IOY_A 56 -------------------QKVDVLLINPVDSDAVVTAIKEANSKNIPVITIDRSANG------GDVVCHIASDNVKGGE 110 (283) T ss_dssp -------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCSS------SCCSEEEEECHHHHHH T ss_pred -------------------CCCCEEEECCCChhHHHHHHHHHHHCCCCEEEEcCCCCC------CCeEEEEecChHHHHH Confidence 46776665 333322223344456689999987754321 2456677777777788 Q NP_000836.2 205 AMVDIVTA--LGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAVI 279 (908) Q Consensus 205 ~~~~~l~~--~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~viv 279 (908) .+++++.+ .+.++++++.. ++.++..+.++|++.+++.++..+....... .+..+....++++++ ..++|+|+ T Consensus 111 ~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~d~i~ 188 (283) T 2IOY_A 111 MAAEFIAKALKGKGNVVELEGIPGASAARDRGKGFDEAIAKYPDIKIVAKQAAD--FDRSKGLSVMENILQAQPKIDAVF 188 (283) T ss_dssp HHHHHHHHHTTTCEEEEEEECCTTCHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHCSCCCEEE T ss_pred HHHHHHHHHcCCCeEEEEEECCCCChhHHHHHHHHHHHHHhCCCeEEEEeecCC--CCHHHHHHHHHHHHHHCCCCCEEE Confidence 88888765 47789999974 3455667778888877664223332111111 111233344445432 13577776 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +.. +..+..+++++++.|.. ++.+++. T Consensus 189 ~~~-~~~a~~~~~~l~~~g~~-~~~iig~ 215 (283) T 2IOY_A 189 AQN-DEMALGAIKAIEAANRQ-GIIVVGF 215 (283) T ss_dssp ESS-HHHHHHHHHHHHHTTCC-CCEEEEE T ss_pred EcC-hhHHHHHHHHHHHcccC-CcEEEEe Confidence 654 34566677777776652 2344443 No 208 >1TLF_C TRYPTIC CORE FRAGMENT OF THE; TRANSCRIPTION REGULATION; HET: IPT, EMC; 2.6A {Escherichia coli} SCOP: c.93.1.1 Probab=97.19 E-value=5.3e-07 Score=91.01 Aligned_cols=200 Identities=12% Similarity=0.076 Sum_probs=116.5 Template_Neff=11.500 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++..+..+++.++++.+ +++.+...+. .+. +...+.+++++ T Consensus 2 ~~~Ig~v~~~~~~------------~~~~~~~~~~~~a~~~~g--------~~l~~~~~~~-~~~----~~~~~~~~~l~ 56 (301) T 1TLF_C 2 SLLIGVATSSLAL------------HAPSQIVAAIKSRADQLG--------ASVVVSMVER-SGV----EACKAAVHNLL 56 (301) T ss_dssp CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------CEEEEEECCS-SSH----HHHHHHHHHHH T ss_pred CceEEEEeCcccc------------chHHHHHHHHHHHHHHcC--------CEEEEEecCC-CcH----HHHHHHHHHHH Confidence 5789999997542 255677788888887753 3333332221 111 12233444433 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . .+++++|+...+.........+...++|+|..+...+ +.++.+.++....+. T Consensus 57 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~--------~~~~~v~~d~~~~~~ 109 (301) T 1TLF_C 57 A-------------------QRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQ--------TPINSIIFSHEDGTR 109 (301) T ss_dssp T-------------------TTCSEEEEESCCCHHHHHHHHHHSTTSCEEESSSCTT--------SSSEEEEECHHHHHH T ss_pred h-------------------CCCCEEEEeCCCCchHHHHHHHHHcCCCEEEEeCCCC--------CCCCeEEeccHHHHH Confidence 2 4788888765443322222235678999988765332 234556666666677 Q NP_000836.2 205 AMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAVIMF 281 (908) Q Consensus 205 ~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~viv~~ 281 (908) .+++++.+.+.++++++.. +..+...+.++|++.+++. ++++....... .+..+....+++++.. .++|+|++. T Consensus 110 ~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~daii~~ 186 (301) T 1TLF_C 110 LGVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRN-QIQPIAEREGD--WSAMSGFQQTMQMLNEGIVPTAMLVA 186 (301) T ss_dssp HHHHHHHHHTCCSEEEEECCTTSHHHHHHHHHHHHHHHHT-TCCCSEEEECC--SSHHHHHHHHHHHHHTTCCCSEEEES T ss_pred HHHHHHHHCCCCeEEEEeCCCCCHHHHHHHHHHHHHHHHC-CCCCeeeecCC--CChHHHHHHHHHHHHcCCCCCEEEEC Confidence 7788776668889999985 3345666778888888775 35443211111 1112233445555421 247788766 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~ 300 (908) . +..+..+++++++.|+. T Consensus 187 ~-~~~a~~~~~~l~~~g~~ 204 (301) T 1TLF_C 187 N-DQMALGAMRAITESGLR 204 (301) T ss_dssp S-HHHHHHHHHHHHHTTCC T ss_pred C-hHHHHHHHHHHHHcCCC Confidence 4 44567788888877764 No 209 >3OQO_C Catabolite control protein A, Phosphocarrier; pbp fold for ccpa, transcription; HET: SEP, SO4; 2.97A {Bacillus subtilis} Probab=97.19 E-value=5.3e-07 Score=92.84 Aligned_cols=204 Identities=9% Similarity=0.065 Sum_probs=119.3 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++.....+++.++++.+ + ++.+.+...++ +...+.++ T Consensus 57 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~~ 110 (339) T 3OQO_C 57 SKKTTTVGVIIPDISS------------IFYSELARGIEDIATMYK--------Y--NIILSNSDQNM----EKELHLLN 110 (339) T ss_dssp HTCCSEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------C--EEEEEECTTCH----HHHHHHHH T ss_pred cCCCCEEEEEeCCCCC------------hHHHHHHHHHHHHHHHcC--------C--EEEEEeCCCCH----HHHHHHHH Confidence 4578899999997542 255677788888877642 2 23334433332 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+.. ......+...++|+|..+...+ .+..+.+.+++.. T Consensus 111 ~l~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~~~~~ 163 (339) T 3OQO_C 111 TMLG-------------------KQVDGIVFMGGNIT-DEHVAEFKRSPVPIVLAASVEE-------QEETPSVAIDYEQ 163 (339) T ss_dssp HHHH-------------------TTCSEEEECCSCCC-HHHHHHHTTCSSCEEEESCCCT-------TCCSCEEECCHHH T ss_pred HHhc-------------------CCCCEEEEcCCCCC-HHHHHHHHhCCCCEEEEcCCCC-------CCCCCEEEcCHHH Confidence 3332 47888887544333 3444556678999998765432 1345566677777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYG---ESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~---~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) .++.+++++.+.+.++++++..+.... ..+.++|++.+++. ++.+........+.+..+....+++++. ..++|+ T Consensus 164 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~d~ 242 (339) T 3OQO_C 164 AIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEA-NLPFNEQFVAEGDYTYDSGLEALQHLMSLDKKPTA 242 (339) T ss_dssp HHHHHHHHHHTTSCSSEEEEECCTTSHHCCCCCCHHHHHHHHTT-TCCCCGGGEEECCSCHHHHHHHHHHHHHSSSCCSE T ss_pred HHHHHHHHHHHCCCCcEEEEeCCCCCcccHHHHHHHHHHHHHHC-CCCcChhheecCCCChhHHHHHHHHHhhcCCCCCE Confidence 777888888767888999998544322 45677888877764 3443211111100112233344555542 146788 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|.. T Consensus 243 i~~~~-~~~a~~~~~~l~~~g~~ 264 (339) T 3OQO_C 243 ILSAT-DEMALGIIHAAQDQGLS 264 (339) T ss_dssp EEESS-HHHHHHHHHHHHTTSCC T ss_pred EEECC-hHHHHHHHHHHHHCCCC Confidence 87664 44556677788777763 No 210 >4RK6_A Glucose-resistance amylase regulator; sugar binding, transcription regulation, Enzyme; HET: MSE, GLC; 1.76A {Weissella paramesenteroides ATCC 33313} Probab=97.19 E-value=5.4e-07 Score=90.02 Aligned_cols=205 Identities=10% Similarity=0.066 Sum_probs=115.0 Template_Neff=12.100 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++.++||++.|..+. .++.....+++.++++.| +++.+.+...+. +...+. T Consensus 5 l~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~----~~~~~~ 58 (287) T 4RK6_A 5 LSSKRSRVVGVVVPLIHT------------NFADEIIKGLYETTISSG----------YELLITYLDEDE----DHQYQV 58 (287) T ss_dssp ------CEEEEEEESSCC------------THHHHHHHHHHHHHHHHT----------CEEEEEEECSCH----HHHHHH T ss_pred hhcCCCCeEEEEecCCCC------------hhHHHHHHHHHHHHHHcC----------CEEEEEECCCCH----HHHHHH Confidence 344578899999996542 255667778887776643 233444443332 223334 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++++.. ++++++|+...+... .....+...++|+|..+...+ +.++++.++. T Consensus 59 ~~~l~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ip~v~~~~~~~--------~~~~~v~~d~ 110 (287) T 4RK6_A 59 FQTLLS-------------------RQVGAVFMLSLDIPS-WMIDKLLEEQISVISLTALLS--------EQISAVTSNE 110 (287) T ss_dssp HHHHHH-------------------TTCSEEEECCSCCCH-HHHHHHHHTTCEEEEESSCCC--------TTSEEEEECH T ss_pred HHHHHh-------------------CCCCEEEEecCCCCH-HHHHHHHhCCCcEEEeCcccC--------CCCCEEEeCH Confidence 444332 478888875443332 344556677999988765332 2455666677 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL--ETPN 274 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~--~~~~ 274 (908) ...++.+++++.+.+.++++++..+.. ++..+.++|++.+++. +..+..........+..+....+++++ ...+ T Consensus 111 ~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 189 (287) T 4RK6_A 111 FEMMNSIVDYLIDMGHKNIALVGDTKLTTNISSTRRTNFIKSMTDH-NLAYENIFLYGNDHSYETGYTSVTTGYDINQLP 189 (287) T ss_dssp HHHHHHHHHHHHHTTCCSEEEESBCCCCSSSCCHHHHHHHHHHHHT-TCCGGGEEEECBSSCHHHHHHCCCCCSCTTSCS T ss_pred HHHHHHHHHHHHHCCCCcEEEEcCCccCCcccHHHHHHHHHHHHHC-CCCcceeEecCCCCChhhhhHHHHhhhhhCCCC Confidence 777778888876667889999985432 5566778888877764 343221111110011122333344432 1236 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +++|++.. +..+..+++++++.|+. T Consensus 190 ~~~i~~~~-~~~a~~~~~~l~~~g~~ 214 (287) T 4RK6_A 190 FTAAIATA-DMVGQGLINAMSDHGKT 214 (287) T ss_dssp CSEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CCEEEEcC-cHHHHHHHHHHHHcCCC Confidence 77776654 44566778888877764 No 211 >4RK7_B Glucose-resistance amylase regulator; sugar binding, transcription regulation, Enzyme; HET: MSE, SUC; 1.8A {Weissella paramesenteroides ATCC 33313} Probab=97.19 E-value=5.4e-07 Score=90.02 Aligned_cols=205 Identities=10% Similarity=0.066 Sum_probs=115.0 Template_Neff=12.100 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++.++||++.|..+. .++.....+++.++++.| +++.+.+...+. +...+. T Consensus 5 l~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~----~~~~~~ 58 (287) T 4RK7_B 5 LSSKRSRVVGVVVPLIHT------------NFADEIIKGLYETTISSG----------YELLITYLDEDE----DHQYQV 58 (287) T ss_dssp ------CEEEEEEESSCC------------THHHHHHHHHHHHHHHTT----------CEEEEEEECSCH----HHHHHH T ss_pred hhcCCCCeEEEEecCCCC------------hhHHHHHHHHHHHHHHcC----------CEEEEEECCCCH----HHHHHH Confidence 344578899999996542 255667778887776643 233444443332 223334 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++++.. ++++++|+...+... .....+...++|+|..+...+ +.++++.++. T Consensus 59 ~~~l~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ip~v~~~~~~~--------~~~~~v~~d~ 110 (287) T 4RK7_B 59 FQTLLS-------------------RQVGAVFMLSLDIPS-WMIDKLLEEQISVISLTALLS--------EQISAVTSNE 110 (287) T ss_dssp HHHHHT-------------------TTCSEEEECCTTCCH-HHHHHHHHTTCEEEEESSCCC--------TTSEEEEECH T ss_pred HHHHHh-------------------CCCCEEEEecCCCCH-HHHHHHHhCCCcEEEeCcccC--------CCCCEEEeCH Confidence 444332 478888875443332 344556677999988765332 2455666677 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL--ETPN 274 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~--~~~~ 274 (908) ...++.+++++.+.+.++++++..+.. ++..+.++|++.+++. +..+..........+..+....+++++ ...+ T Consensus 111 ~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 189 (287) T 4RK7_B 111 FEMMNSIVDYLIDMGHKNIALVGDTKLTTNISSTRRTNFIKSMTDH-NLAYENIFLYGNDHSYETGYTSVTTGYDINQLP 189 (287) T ss_dssp HHHHHHHHHHHHHTTCCSEEEESBCCCCSSSCCHHHHHHHHHHHHT-TCCGGGEEEECBSSCHHHHHHCCCCCSCTTSCS T ss_pred HHHHHHHHHHHHHCCCCcEEEEcCCccCCcccHHHHHHHHHHHHHC-CCCcceeEecCCCCChhhhhHHHHhhhhhCCCC Confidence 777778888876667889999985432 5566778888877764 343221111110011122333344432 1236 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +++|++.. +..+..+++++++.|+. T Consensus 190 ~~~i~~~~-~~~a~~~~~~l~~~g~~ 214 (287) T 4RK7_B 190 FTAAIATA-DMVGQGLINAMSDHGKT 214 (287) T ss_dssp CSEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CCEEEEcC-cHHHHHHHHHHHHcCCC Confidence 77776654 44566778888877764 No 212 >4RWE_A Sugar-binding transport protein; structural genomics, The Center for; 1.65A {Yersinia pestis} Probab=97.17 E-value=6e-07 Score=89.98 Aligned_cols=213 Identities=12% Similarity=0.043 Sum_probs=120.4 Template_Neff=12.000 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .+.++||++.|..+. .++.....+++.++++.| |..+++.+.++..++. ...+.+++ T Consensus 3 ~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~~-------g~~~~~~~~~~~~~~~----~~~~~~~~ 59 (292) T 4RWE_A 3 AELNSIGVTVGDLAN------------PFFVQITKGVELEARKLA-------GDKVKVTLVSSGYDLG----QQVAQIDN 59 (292) T ss_dssp -CCCEEEEEESCTTS------------HHHHHHHHHHHHHHHHHH-------CTTCEEEEEECTTCHH----HHHHHHHH T ss_pred cccceEEEEecccCC------------HHHHHHHHHHHHHHHHHc-------CCceEEEEecCCCCHH----HHHHHHHH Confidence 467899999997542 256678888888888765 2345555556544322 22333443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. ++++++|+...+.. .......+...++|+|..+...+ ++.+++.+++.. T Consensus 60 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~--------~~~~~v~~d~~~ 112 (292) T 4RWE_A 60 FIA-------------------AKVDMIILNAADSKGIGPAVKRAKDAGIVVVAVDVAAE--------GADATITSDNTQ 112 (292) T ss_dssp HHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCEEEEESSCCT--------TCSEEEEECHHH T ss_pred HHH-------------------CCCCEEEEeCCCccchHHHHHHHHHCCCEEEEEcCCCC--------CCceEEecCHHH Confidence 332 46787776443322 22334455667999998765432 135566677777 Q NP_000836.2 202 QAQAMVDIVTALG--WNYVSTLAS-EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~--~~~v~ii~~-~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) .++.+++++.+.+ .++++++.. ...++..+.++|++.+++.+++.+....... ..+..+....++++++. .++++ T Consensus 113 ~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~ 191 (292) T 4RWE_A 113 AGAMACKYISDRLKEKGNVVIINGPPVSAIQNRVEGCESEFKKYPDIKVLSSNQNA-KGSREGGLEVMTSLLAVNPKIDG 191 (292) T ss_dssp HHHHHHHHHHHHTTTEEEEEEEBCCSSHHHHHHHHHHHHHHTTCTEEEEEECCCBC-TTSHHHHHHHHHHHHHHCSCCCE T ss_pred HHHHHHHHHHHHhCCCceEEEEeCCCChHHHHHHHHHHHHHHHCCCcEEEeeccCC-CCcHHHHHHHHHHHHHhCCCCCE Confidence 7778888775543 778998884 3345556677788777664223332211000 01112233445555421 24566 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) |++.. +..+..+++++++.|.. ++.+++. T Consensus 192 i~~~~-~~~a~~~~~~~~~~g~~-~~~i~~~ 220 (292) T 4RWE_A 192 VFAIN-DPTAIGADLAAKQAQRN-EFFIVGV 220 (292) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC-SSEEECS T ss_pred EEEcC-ChHHHHHHHHHHHcCCC-CeEEEEe Confidence 66553 44566777788777642 3344443 No 213 >3GV0_A Transcriptional regulator, LacI family; Transcription regulator, PSI-II, 11224e, Structural; 2.35A {Agrobacterium tumefaciens str.} Probab=97.16 E-value=6.1e-07 Score=89.81 Aligned_cols=207 Identities=8% Similarity=0.078 Sum_probs=116.3 Template_Neff=11.800 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++.++||++.|.++.. ..++..+..+++.++++.+ ++ +.+.+...+.. .. ..+ T Consensus 4 ~~~~~~~Ig~~~~~~~~~----------~~~~~~~~~~~~~~~~~~g--------~~--~~~~~~~~~~~----~~-~~~ 58 (288) T 3GV0_A 4 RTGKTNVIALVLSVDEEL----------MGFTSQMVFGITEVLSTTQ--------YH--LVVTPHIHAKD----SM-VPI 58 (288) T ss_dssp ---CCCEEEEECBCCCCS----------SCHHHHHHHHHHHHHTTSS--------CE--EEECCBSSGGG----TT-HHH T ss_pred CCCCccEEEEEeecchHc----------ChHHHHHHHHHHHHHHhcC--------cE--EEEEecCCCcc----cc-hhH Confidence 345689999999975321 1245667788888877642 33 33344332211 11 112 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) .+.+. .+++|++|+...+... .....+...++|+|.++...+ .+..+.+..++. T Consensus 59 ~~~~~------------------~~~~d~ii~~~~~~~~-~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~ 112 (288) T 3GV0_A 59 RYILE------------------TGSADGVIISKIEPND-PRVRFMTERNMPFVTHGRSDM-------GIEHAFHDFDNE 112 (288) T ss_dssp HHHHH------------------HTCCSEEEEESCCTTC-HHHHHHHHTTCCEEEESCCCS-------SCCCEEEEECHH T ss_pred HHHHH------------------hCCCCEEEEeCCCCCC-HHHHHHHHcCCCEEEeCCCCC-------CCCCcEEecCcH Confidence 22111 1578888876544333 444556678999998776432 123455666666 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNY--GESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~--~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) ..++.+++++.+.+.++++++..+..+ ...+.++|++.+++. ++.+........+.+..+....+++++. ..++|+ T Consensus 113 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~d~ 191 (288) T 3GV0_A 113 AYAYEAVERLAQCGRKRIAVIVPPSRFSFHDHARKGFNRGIRDF-GLTEFPIDAVTIETPLEKIRDFGQRLMQSSDRPDG 191 (288) T ss_dssp HHHHHHHHHHHHTTCCEEEEECCCTTSHHHHHHHHHHHHHHHHT-TCEECCCCSCCTTSCHHHHHHHHHHHTTSSSCCSE T ss_pred HHHHHHHHHHHHCCCCeEEEECCCCCCchHHHHHHHHHHHHHHc-CCCCCCceeEEeCCCHHHHHHHHHHHHccCCCCCE Confidence 677778888766788899999864433 445677888877764 3433221001100111233344555532 236788 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|.. T Consensus 192 i~~~~-~~~a~~~~~~l~~~g~~ 213 (288) T 3GV0_A 192 IVSIS-GSSTIALVAGFEAAGVK 213 (288) T ss_dssp EEESC-HHHHHHHHHHHHTTTCC T ss_pred EEEcC-HHHHHHHHHHHHHcCCC Confidence 77664 44566778888877764 No 214 >5HKO_A ABC transporter, carbohydrate uptake transporter-2; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: ACT, 62W, IMD, ZN; 1.2A {Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)} Probab=97.16 E-value=6.3e-07 Score=92.68 Aligned_cols=214 Identities=13% Similarity=0.076 Sum_probs=118.8 Template_Neff=10.600 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++.++||++.|... .++.....+++.++++.+ +++.+.|...+.. ...+. T Consensus 28 ~~~~~~~~Ig~v~~~~~-------------~~~~~~~~g~~~a~~~~g----------~~l~~~~~~~~~~----~~~~~ 80 (348) T 5HKO_A 28 AANSDTKRIGVTVYDMS-------------SFITEGKEGMDTYAKANN----------IELVWNSANNDVS----TQASQ 80 (348) T ss_dssp -----CEEEEEEESCCC-------------HHHHHHHHHHHHHHHHTT----------EEEEEEECTTCHH----HHHHH T ss_pred cccCCCcEEEEEECCCC-------------HHHHHHHHHHHHHHHHCC----------CEEEEecCCCCHH----HHHHH Confidence 45567899999998652 245566777777776642 3444555443321 22233 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. .+++++|....+.. .......+...++|+|..+...+. .++++++.++ T Consensus 81 i~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d 135 (348) T 5HKO_A 81 VDSLIN-------------------QGVDAIIVVPVQADSLGPQVASAKSKGIPLLAVNAALET------PDLAGNVQPD 135 (348) T ss_dssp HHHHHH-------------------TTCSEEEEECSCSSCCHHHHHHHHHTTCCEEEESSCCCC------TTCSEEEEEC T ss_pred HHHHHH-------------------CCCCEEEEeCCCccccHHHHHHHHHCCCCEEEEcCCCCC------CCCceEEcCC Confidence 343332 46787776443322 223445566789999987654321 2345677777 Q NP_000836.2 199 DSYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-- 272 (908) Q Consensus 199 ~~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-- 272 (908) +...++.+++++.+. +.++++++.. ++.+...+.++|++.+++.+++.+....... .+..+....+++++.. T Consensus 136 ~~~~g~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~ 213 (348) T 5HKO_A 136 DVAAGAQEMQMMADRLGGKGNIVILQGPLGGSGEINRGKGIDQVLAKYPDIKVLAKDTAN--WKRDEAVNKMKNWISSFG 213 (348) T ss_dssp HHHHHHHHHHHHHHHHTTCEEEEEEECSTTSHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHHG T ss_pred HHHHHHHHHHHHHHHhCCCcEEEEEECCCCChHHHHHHHHHHHHHHhCCCcEEEEeecCC--CCHHHHHHHHHHHHHHhC Confidence 777777888877544 6788999885 3345566777888877663223332111111 1112333445555421 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSD 309 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~ 309 (908) .++|+|++.. +..+..+++++++.|.. ++.+++.+ T Consensus 214 ~~~d~I~~~~-d~~a~~~~~al~~~g~~-~i~iig~d 248 (348) T 5HKO_A 214 PQIDGVVAQN-DDMGLGALQALKEAGRT-GVPIVGID 248 (348) T ss_dssp GGCCEEEESS-HHHHHHHHHHHHHTTCC-SCCEECSB T ss_pred CCCCEEEECC-hHHHHHHHHHHHHcCCC-CCCEEEec Confidence 2477777664 44566778888877763 33444443 No 215 >4RXU_A Periplasmic sugar-binding protein; SUGAR TRANSPORTER, ABC-TYPE, ENZYME FUNCTION; HET: BGC, CIT; 1.4A {Chloroflexus aurantiacus} Probab=97.15 E-value=6.5e-07 Score=93.42 Aligned_cols=153 Identities=17% Similarity=0.075 Sum_probs=91.9 Template_Neff=10.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) ....++.++||++.|..+. .++..+..+++.++++.| +++.+.|...+. +...+ T Consensus 24 ~~~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~a~~~~g----------~~l~~~~~~~~~----~~~~~ 77 (367) T 4RXU_A 24 STGNTQQLAVGIVLPTKDE------------PRWIQDETRFREALQQAG----------YQVEILFSQGSS----AKEKE 77 (367) T ss_dssp ----CEEEEEEEEESCSSS------------THHHHHHHHHHHHHHHHT----------EEEEEEECTTCH----HHHHH T ss_pred CCCCCCCeEEEEEeCCCCC------------hHHHhHHHHHHHHHHHcC----------CEEEEEecCCCH----HHHHH Confidence 3456678999999997542 255677788888887753 344445544332 22333 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGA-AASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~-~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. ++++++|.. ..+.........+...++|+|..+...+. ..++.+++.+ T Consensus 78 ~i~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvi~~~~~~~~-----~~~~~~~v~~ 133 (367) T 4RXU_A 78 NVEALIA-------------------KGIKVLIICPHDGTAAAAAAEAARAAGVKVISYDRLIRE-----TDAVDYYVTF 133 (367) T ss_dssp HHHHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCEEEEESSCCCS-----CSCCCEEEEE T ss_pred HHHHHHH-------------------cCCCEEEEcCCChhHHHHHHHHHHHCCCEEEEecCCCCC-----CCCccEEEEc Confidence 3444332 467766643 33333334455567789999987764432 1244567777 Q NP_000836.2 198 PDSYQAQAMVDIVTAL--GWNYVSTLA---SEGNYGESGVEAFTQISRE 241 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~--~~~~v~ii~---~~~~~~~~~~~~~~~~~~~ 241 (908) ++...++.+++++.+. +.++++++. .++.+...+.++|++.+++ T Consensus 134 d~~~~g~~~~~~l~~~~~g~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~ 182 (367) T 4RXU_A 134 DSIAVGAQQAQYLVDHASGTGNPLYLYAGAASDNNAFLFFEGAWKVLQP 182 (367) T ss_dssp CHHHHHHHHHHHHHHTCCSSCEEEEECBCCTTSHHHHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHccCCCCcEEEEecCCCChhHHHHHHHHHHHHHH Confidence 7777788888887654 778899886 2334555666677666654 No 216 >4KMR_A Transcriptional regulator, LacI family; Structural Genomics, PSI-Biology, Midwest Center; 1.45A {Sanguibacter keddieii} Probab=97.14 E-value=6.7e-07 Score=88.91 Aligned_cols=201 Identities=12% Similarity=0.072 Sum_probs=113.6 Template_Neff=12.100 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) +..+||++.|..+. .++.....+++.++++.| +.+.+.|+..++. ...+.++++ T Consensus 2 ~~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~~~ 55 (280) T 4KMR_A 2 RSGVIGLAVPELGQ------------AFFAQLADEVIRVAAEQD----------LVVLVEQTGGLRE----RELEALRNP 55 (280) T ss_dssp CCSEEEEEESCTTS------------HHHHHHHHHHHHHHHTTT----------CEEEEEECTTCHH----HHHHHHHCG T ss_pred CcceEEEEeCccch------------HHHHHHHHHHHHHHHHCC----------CEEEEEecCCchH----HHHHHHHhh Confidence 46789999987542 256678888888887763 2334445433321 222333333 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) +. +++|++|+...+..... ..+...++|+|..+...+ .++.+.+.+++...+ T Consensus 56 ~~-------------------~~~d~ii~~~~~~~~~~--~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~~~~ 107 (280) T 4KMR_A 56 RL-------------------SLTDGLLLAPLGLTQDD--VLPDPAGRPLVVLGEPLF-------PGPVDHVTMQHEAAA 107 (280) T ss_dssp GG-------------------TTCSCEEECCSSCC-CC--C------CCEEEESSSCC-------CSSCEEECCCHHHHH T ss_pred HH-------------------hcCCEEEEecCCCCCcc--cCcCcCCCcEEEECCCCC-------CCCCCEEEcCHHHHH Confidence 32 47888876544332221 234678999998776432 134566677777777 Q NP_000836.2 204 QAMVDIVTALGWNYVSTLASEG----NYGESGVEAFTQISREIGGVCIAQSQKIP-REPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 204 ~~~~~~l~~~~~~~v~ii~~~~----~~~~~~~~~~~~~~~~~~~i~v~~~~~~~-~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) +.+++++.+.+.++++++..+. .++..+.+++++.+++. ++.+.....+. ...+..+....++++++ ..++++ T Consensus 108 ~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 186 (280) T 4KMR_A 108 RAATEHLLGLGRRRVMLLGAHATERTGVAALRYAGYREALTAA-GLAVDDDLVVPVETWDRSSGAEAMARVLDAGVRMDA 186 (280) T ss_dssp HHHHHHHHHTTCCCEEEETSCSSCCCHHHHHHHHHHHHHHHHT-TCCCCGGGEECCSSCSHHHHHHHHHHHHHTTCCCSE T ss_pred HHHHHHHHHCCCCeEEEEecCcccCchhHHHHHHHHHHHHHHc-CCCCCCCeEeecCCCChhHHHHHHHHHHHcCCCCCE Confidence 7888888767889999998543 35566778888888765 34433211111 00111223344455442 135777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 187 i~~~~-~~~a~~~~~~~~~~g~~ 208 (280) T 4KMR_A 187 VFAMN-DDLALGALRSLQERGVA 208 (280) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 77664 44566778888877764 No 217 >3L6U_A ABC-TYPE SUGAR TRANSPORT SYSTEM PERIPLASMIC; structural genomics, NYSGRC, target 11006s; HET: MSE, SO4; 1.9A {Exiguobacterium sibiricum} Probab=97.14 E-value=6.8e-07 Score=89.71 Aligned_cols=205 Identities=11% Similarity=0.062 Sum_probs=114.7 Template_Neff=11.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++.....+++.++++.+ +++.+.+...++. ...+.++ T Consensus 5 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~~----~~~~~~~ 58 (293) T 3L6U_A 5 SPKRNIVGFTIVNDKH------------EFAQRLINAFKAEAKANK----------YEALVATSQNSRI----SEREQIL 58 (293) T ss_dssp ----CEEEEEESCSCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECSSCHH----HHHHHHH T ss_pred CCCCcEEEEEECCCCC------------HHHHHHHHHHHHHHHHCC----------CeEEEecCCCCHH----HHHHHHH Confidence 4567899999987542 245667788888877652 2344444433321 2223333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. +++|++|+...+... ......+...++|+|..+...+. .++++++.+++. T Consensus 59 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 113 (293) T 3L6U_A 59 EFVH-------------------LKVDAIFITTLDDVYIGSAIEEAKKAGIPVFAIDRMIRS------DAVVSSITSNNQ 113 (293) T ss_dssp HHHH-------------------TTCSEEEEECSCTTTTHHHHHHHHHTTCCEEEESSCCCC------TTCSEEEEECHH T ss_pred HHHh-------------------cCCCEEEEecCCcchHHHHHHHHHHcCCCEEEEcCCCCC------CccceEEecChH Confidence 3332 478888765433322 24445566789999987654321 245667777777 Q NP_000836.2 201 YQAQAMVDIVTAL-------GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 201 ~~~~~~~~~l~~~-------~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) ..++.+++++.+. +.++++++.. +..++..+.+++++.+++.+.+.+....... .+..+....++++++ T Consensus 114 ~~~~~~~~~l~~~~~~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~ 191 (293) T 3L6U_A 114 MIGEQLASYIKNELIKQTGRSTGRIVEITGTANVYTTNERHRGFLKGIENEPTLSIVDSVSGN--YDPVTSERVMRQVID 191 (293) T ss_dssp HHHHHHHHHHHHHHHHHHSCSCEEEEEEECSTTCHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHhCCCceEEEEEEcCCCChhHHHHHHHHHHHHHhCCCceEEeeeeCC--CCHHHHHHHHHHHHH Confidence 7777777776432 4578988875 3345666777888877664222332111111 111223344455542 Q NP_000836.2 272 T-PNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 ~-~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) . .++++|++.. +..+..+++++++.|+. T Consensus 192 ~~~~~~~i~~~~-~~~a~~~~~al~~~g~~ 220 (293) T 3L6U_A 192 SGIPFDAVYCHN-DDIAMGVLEALKKAKIS 220 (293) T ss_dssp TTCCCSEEEESS-HHHHHHHHHHHHHTTCC T ss_pred hCCCCCEEEECC-hHHHHHHHHHHHHCCCC Confidence 1 2477777664 44566778888877764 No 218 >2DRI_A D-RIBOSE-BINDING PROTEIN COMPLEXED WITH BETA-D-RIBOSE; SUGAR TRANSPORT; HET: RIP; 1.6A {Escherichia coli} SCOP: c.93.1.1 Probab=97.14 E-value=6.8e-07 Score=88.20 Aligned_cols=207 Identities=14% Similarity=0.114 Sum_probs=116.2 Template_Neff=12.400 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIE 125 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~~ 125 (908) .+||++.|..+. ..+.....+++.++++.| +++.+.|+..+.. ...+.++++.. T Consensus 2 ~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~~~~~ 55 (271) T 2DRI_A 2 DTIALVVSTLNN------------PFFVSLKDGAQKEADKLG----------YNLVVLDSQNNPA----KELANVQDLTV 55 (271) T ss_dssp CEEEEEESCSSS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCHH----HHHHHHHHHTT T ss_pred CeEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCHH----HHHHHHHHHHH Confidence 478888887542 255677788888887753 3344455433321 22233333332 Q NP_000836.2 126 KDASDVKCANGDPPIFTKPDKISGVI-GAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 126 ~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) +++++++ ++..+.........+.+.++|+|..+...+. .++++++.+++...++ T Consensus 56 -------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~d~~~~~~ 110 (271) T 2DRI_A 56 -------------------RGTKILLINPTDSDAVGNAVKMANQANIPVITLDRQATK------GEVVSHIASDNVLGGK 110 (271) T ss_dssp -------------------TTEEEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCSS------SCCSEEEEECHHHHHH T ss_pred -------------------CCCCEEEEecCCcchHHHHHHHHHHCCCCEEEEcCCCCC------CceEEEEEeCcHHHHH Confidence 3566554 4433333334445567789999987754321 2456777777777788 Q NP_000836.2 205 AMVDIVTALGW--NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAVI 279 (908) Q Consensus 205 ~~~~~l~~~~~--~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~viv 279 (908) .+++++.+.+. .+++++.. +..++..+.+++++.+++. ++++....... .+..+....+++++.. .++++|+ T Consensus 111 ~~~~~l~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~~i~ 187 (271) T 2DRI_A 111 IAGDYIAKKAGEGAKVIELQGIAGTSAARERGEGFQQAVAAH-KFNVLASQPAD--FDRIKGLNVMQNLLTAHPDVQAVF 187 (271) T ss_dssp HHHHHHHHHHCTTCEEEEEECCTTCHHHHHHHHHHHHHHHHH-TCEEEEEEECT--TCHHHHHHHHHHHHHHCTTCCEEE T ss_pred HHHHHHHHHhCCCceEEEEEcCCCChhHHHHHHHHHHHHHhc-CceEEEeecCC--CcHHHHHHHHHHHHHHCCCCCEEE Confidence 88888755432 35666652 3445667778888888775 35543221111 1122344445555421 2477776 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +.. +..+..+++++++.|.. ++.+++. T Consensus 188 ~~~-~~~~~~~~~~~~~~g~~-~~~i~~~ 214 (271) T 2DRI_A 188 AQN-DEMALGALRALQTAGKS-DVMVVGF 214 (271) T ss_dssp ESS-HHHHHHHHHHHHHHTCC-SCEEEEE T ss_pred eCC-HHHHHHHHHHHHHcCCC-CcEEEEe Confidence 654 34466777888777652 3344443 No 219 >3D02_A Putative LACI-type transcriptional regulator; YP_001338366.1, periplasmic sugar-binding protein, Structural; HET: GOL; 1.3A {Klebsiella pneumoniae subsp. pneumoniae} Probab=97.14 E-value=6.9e-07 Score=90.14 Aligned_cols=214 Identities=13% Similarity=0.071 Sum_probs=117.2 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||++.|..+. .++.....+++.++++++ +++.+. .+...++ ....+.+++ T Consensus 2 ~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~-~~~~~~~----~~~~~~~~~ 56 (303) T 3D02_A 2 AAEKTVVNISKVDGM------------PWFNRMGEGVVQAGKEFN--------LNASQV-GPSSTDA----PQQVKIIED 56 (303) T ss_dssp --CEEEEEECSCSSC------------HHHHHHHHHHHHHHHHTT--------EEEEEE-CCSSSCH----HHHHHHHHH T ss_pred CCceEEEEEeCCCCC------------hHHHHHHHHHHHHHHHcC--------CEEEEe-CCCCCCH----HHHHHHHHH Confidence 357899999997542 255677888888888763 344443 2332332 223334444 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGA-AASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~-~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. ++++++|+. ..+.........+...++|+|......+. .++++++..+... T Consensus 57 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~~~~~~~~ 111 (303) T 3D02_A 57 LIA-------------------RKVDAITIVPNDANVLEPVFKKARDAGIVVLTNESPGQP------SANWDVEIIDNEK 111 (303) T ss_dssp HHH-------------------TTCSEEEECCSCHHHHHHHHHHHHHTTCEEEEESCTTCT------TCSEEEESSCHHH T ss_pred HHH-------------------CCCCEEEECCCCccchHHHHHHHHHCCCEEEEeCCCCCC------ccceeEeeeChHH Confidence 332 467877753 33333334455566789999987654321 2345556666666 Q NP_000836.2 202 QAQAMVDIVTA-LGW-NYVSTLAS--EGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLET-PNA 275 (908) Q Consensus 202 ~~~~~~~~l~~-~~~-~~v~ii~~--~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~ 275 (908) .+..+++++.+ .+. ++++++.. ++.++..+.++|++.+++.+ ++++.... .....+..+....+++++.. .++ T Consensus 112 ~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~ 190 (303) T 3D02_A 112 FAAEYVEHMAKRMGGKGGYVIYVGSLTVPQHNLWADLLVKYQKEHYPDMHEVTRR-MPVAESVDDSRRTTLDLMKTYPDL 190 (303) T ss_dssp HHHHHHHHHHHHTTTCEEEEEECSCSSCHHHHHHHHHHHHHHHHHCTTEEESSSC-BSCTTCHHHHHHHHHHHHHHCTTE T ss_pred HHHHHHHHHHHHhCCCeeEEEEECCCCChhHHHHHHHHHHHHHHHCCCceEeecc-CCCCCCHHHHHHHHHHHHHHCCCc Confidence 67777777654 366 68998875 33455667778877776531 23332211 01001112333445555421 245 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|++.. +..+..+++++++.|...++.+++. T Consensus 191 ~~i~~~~-~~~a~~~~~a~~~~g~~~~~~v~~~ 222 (303) T 3D02_A 191 KAVVSFG-SNGPIGAGRAVKEKRAKNKVAVYGM 222 (303) T ss_dssp EEEEESS-TTHHHHHHHHHHHTTCTTTCEEEEC T ss_pred cEEEEeC-CCchHHHHHHHHHhccCCCeEEEEe Confidence 6665543 4455668888888776323444443 No 220 >4WZZ_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: RAM, EDO, MSE; 1.7A {Clostridium phytofermentans} Probab=97.13 E-value=7.2e-07 Score=93.23 Aligned_cols=215 Identities=11% Similarity=0.034 Sum_probs=119.6 Template_Neff=11.000 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTF 119 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~ 119 (908) ...++++||++.|..+. .++..+..+++.++++.+ + ++.+.+.. .+. +...+. T Consensus 50 ~~~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~l~~~~~~~~~~----~~~~~~ 103 (371) T 4WZZ_A 50 GYATTATYAIIVKSAGN------------PYNQKESEGYKQVIEANG--------G--KCVIQEPKSATA----EDQITC 103 (371) T ss_dssp -CCCCCEEEEECSCSSC------------HHHHHHHHHHHHHHHHTT--------C--EEEEECCSSSSH----HHHHHH T ss_pred CCCCCcEEEEEEcCCCC------------HHHHHHHHHHHHHHHHcC--------C--EEEEECCCCCCH----HHHHHH Confidence 35678999999987542 255677788888887752 3 33344433 232 233344 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGA-AASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~-~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. +++|++|+. ..+.........+...++|+|..+...+. ..++.+....+ T Consensus 104 ~~~li~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~v~~~~ 159 (371) T 4WZZ_A 104 INNAIS-------------------QGVDCIAIAANDTDALEPALTEAKNQGIHVLSLDSATNA-----NSRKVFVNQAG 159 (371) T ss_dssp HHHHHH-------------------HTCSEEEECCSSSSTTHHHHHHHHHTTCEEEEESSCCCG-----GGCSCEEESSC T ss_pred HHHHHH-------------------cCCCEEEEcCCCHHhHHHHHHHHHHCCCEEEEECCCCCc-----cccceEEeccC Confidence 444432 478888764 33333334455667789999987764432 12233444334 Q NP_000836.2 199 DSYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREI--GGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 199 ~~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~--~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) ....++.+++++.+. +.++++++.. ++.+...+.++|++.+++. .++++....... .+..+....++++++. T Consensus 160 ~~~~~~~~~~~l~~~~~g~~~v~~l~~~~~~~~~~~r~~g~~~~~~~~~~~~~~v~~~~~~~--~~~~~~~~~~~~~l~~ 237 (371) T 4WZZ_A 160 TTQIAQALMDAILDISGGSGDWAVLSAASTATNQNAWIDGMKTVMQDSKYSKLNLIGVYYGD--DEYQASCDQTEAILAA 237 (371) T ss_dssp HHHHHHHHHHHHHHHTTSCEEEEEEESCTTCHHHHHHHHHHHHHTTSGGGTTEEEEEEEECT--TCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHhCCCeeEEEEECCCCcHhHHHHHHHHHHHHhhccCCCcEEEEEecCC--CCHHHHHHHHHHHHHH Confidence 555677777777553 5678998873 3445667778888877642 124433221111 1122344455555431 Q NP_000836.2 273 -PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 273 -~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) .+.++|+.. ++..+..+++++++.|+..++.+++. T Consensus 238 ~~~~~~i~~~-~~~~a~~~~~al~~~g~~~~v~v~~~ 273 (371) T 4WZZ_A 238 DPNIKVICAP-TTVGIMAAAKVLQDKGLSGKVKLTGL 273 (371) T ss_dssp CTTCCEEEEC-SHHHHHHHHHHHHHTTCTTTSEEEEB T ss_pred CCCCCEEEeC-CchHHHHHHHHHHHCCCCCCeEEEec Confidence 234555443 34456677888888776323444443 No 221 >1JX6_A LUXP PROTEIN; PROTEIN-LIGAND COMPLEX, SIGNALING PROTEIN; HET: AI2; 1.5A {Vibrio harveyi} SCOP: c.93.1.1 Probab=97.13 E-value=7.2e-07 Score=91.91 Aligned_cols=222 Identities=11% Similarity=0.029 Sum_probs=124.3 Template_Neff=11.600 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+.. .+......+++.++++.+. .+.+++.+.|+..++. ...+.++ T Consensus 40 ~~~~~~Igvv~~~~~~~-----------~~~~~~~~g~~~~~~~~g~------~~~~~~~~~d~~~~~~----~~~~~~~ 98 (342) T 1JX6_A 40 TQRPIKISVVYPGQQVS-----------DYWVRNIASFEKRLYKLNI------NYQLNQVFTRPNADIK----QQSLSLM 98 (342) T ss_dssp CSSCEEEEEEECCCSSC-----------CHHHHHHHHHHHHHHHTTC------CEEEEEEECCTTCCHH----HHHHHHH T ss_pred CCCCEEEEEEecCCCCC-----------HHHHHHHHHHHHHHHHcCC------eEEEEEEecCCCCCHH----HHHHHHH Confidence 56789999999975321 1334778888888887642 1223334556544422 2333444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRL-FKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~-~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. ++++++|+...+.........+.. .++|+|..+...+.... ...++++++.+++. T Consensus 99 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~-~~~~~~~~v~~d~~ 158 (342) T 1JX6_A 99 EALK-------------------SKSDYLIFTLDTTRHRKFVEHVLDSTNTKLILQNITTPVREW-DKHQPFLYVGFDHA 158 (342) T ss_dssp HHHH-------------------TTCSEEEECCSSSTTHHHHHHHHHHCSCEEEEETCCSCBGGG-TTSCCSEEEECCHH T ss_pred HHHh-------------------cCCCEEEEeCCchHHHHHHHHHHHhCCCeEEEEeCCCCcchh-cCCCCeEEEEcChH Confidence 4432 478888876533332333444443 78999987654432111 01356777888887 Q NP_000836.2 201 YQAQAMVDIVTALGWN--YVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~--~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ..+..+++++.+.+.+ +++++... +.++..+.+++++.+++.+++++....... .+..+....+++++.. .+++ T Consensus 159 ~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~ 236 (342) T 1JX6_A 159 EGSRELATEFGKFFPKHTYYSVLYFSEGYISDVRGDTFIHQVNRDNNFELQSAYYTK--ATKQSGYDAAKASLAKHPDVD 236 (342) T ss_dssp HHHHHHHHHHHHHSCTTCEEEEECCSTTHHCCCCCCHHHHHHHHHHCCEEEEEECCC--SSHHHHHHHHHHHHHHCCCCS T ss_pred HHHHHHHHHHHHhcCCCCeEEEEEecCCcchHHHHHHHHHHHHhcCCceEEeeeccC--CCHHHHHHHHHHHHHHCCCCC Confidence 7888888887654443 48888754 445667777888877653223332211111 1122344455555421 2455 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|+.. ++..+..+++++++.|. .++.+++. T Consensus 237 ~i~~~-~~~~a~~~~~~~~~~g~-~~~~v~~~ 266 (342) T 1JX6_A 237 FIYAC-STDVALGAVDALAELGR-EDIMINGW 266 (342) T ss_dssp EEEES-SHHHHHHHHHHHHHHTC-TTSEEBCS T ss_pred EEEEC-CHHHHHHHHHHHHHcCC-CCcEEEee Confidence 55554 34455667888887776 23344443 No 222 >4WT7_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; Enzyme Function Initiative, EFI, Structural; HET: X9X; 2.0A {Agrobacterium vitis S4} Probab=97.12 E-value=7.7e-07 Score=90.79 Aligned_cols=202 Identities=10% Similarity=-0.005 Sum_probs=116.3 Template_Neff=11.400 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|.++. .+......+++.++++. .+++.+.|+..++. ...+.++ T Consensus 29 ~~~~~~Ig~v~~~~~~------------~~~~~~~~~~~~a~~~~----------~~~l~~~~~~~~~~----~~~~~~~ 82 (321) T 4WT7_A 29 SLKGKRIGISTAGTDH------------FFDLQAYNAQIAEVKRL----------GGEPLAVDAGRSDG----KLVAQLQ 82 (321) T ss_dssp CCTTCEEEEEESCCSS------------HHHHHHHHHHHHHHHHT----------TCEEEEEECTTCHH----HHHHHHH T ss_pred hcCCcEEEEEcCCCCc------------HHHHHHHHHHHHHHHHc----------CCeEEEEeCCCCHH----HHHHHHH Confidence 4478999999997532 12334556666666543 24455556544322 2333444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAA-ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. ++++++|... .+.........+.+.++|+|..+...+ ++++++.+++. T Consensus 83 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~--------~~~~~v~~d~~ 135 (321) T 4WT7_A 83 TLIA-------------------QKPDAIVQLLGTLTVIDPWLKRARDAGIPVLTIDVGSS--------HSLNNSTSDNW 135 (321) T ss_dssp HHHH-------------------HCCSEEEEECCCHHHHHHHHHHHHHTTCCEEEESCCCT--------TCSCEEECCHH T ss_pred HHHH-------------------CCCCEEEEcCCChhhhHHHHHHHHHcCCCEEEECCCCC--------CcceeecCChH Confidence 4332 4677766543 333333445566778999998765432 34667777777 Q NP_000836.2 201 YQAQAMVDIVTA--LGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQ--KIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 201 ~~~~~~~~~l~~--~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~--~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) ..++.+++++.+ .+.++++++.. +..++..+.++|++.+++.+++++.... ... ..+..+....++++++ .+ T Consensus 136 ~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~-~~ 213 (321) T 4WT7_A 136 GIGKDLALQLVSDIGGEGNVVVFNGFYGVTPCAIRYDQLVNVIKYFPKVKIIQPELRDVI-PNTVQDAFAQVTAILN-KY 213 (321) T ss_dssp HHHHHHHHHHHHHTTTCEEEEEECCCTTSHHHHHHHHHHHHHHTTSTTEEECSSCBCCCS-SSHHHHHHHHHHHHHH-HS T ss_pred HHHHHHHHHHHHHhCCCceEEEEEcCCCCCcHHHHHHHHHHHHHHCCCcEEEcccccCCC-CCCHHHHHHHHHHHHH-HC Confidence 777777777755 47788999985 4456667788888877653213332210 010 0112234445555553 23 Q NP_000836.2 275 -----ARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 275 -----~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) +++|++.. +..+..+++++++.|. T Consensus 214 ~~~~~~~~i~~~~-~~~a~~~~~~l~~~g~ 242 (321) T 4WT7_A 214 PEKGSIKAIWSAW-DIPQLGATQALAAAGR 242 (321) T ss_dssp CSTTSCCEEEESS-HHHHHHHHHHHHHHTC T ss_pred CCcCCccEEEeCC-ChhHHHHHHHHHHCCC Confidence 56666553 4556678888887776 No 223 >2RJO_A Twin-arginine translocation pathway signal protein; PSI-2, NYSGXRC, twin arginine translocation; HET: SO4, GAL; 2.05A {Burkholderia phytofirmans} Probab=97.09 E-value=8.7e-07 Score=90.86 Aligned_cols=217 Identities=10% Similarity=0.034 Sum_probs=119.1 Template_Neff=11.400 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||++.|..+. .++..+..+++.++++.| +++.+.|+..++. ...+.+++ T Consensus 3 ~~~~~Igvv~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~~ 56 (332) T 2RJO_A 3 LGQTTLACSFRSLTN------------PYYTAFNKGAQSFAKSVG----------LPYVPLTTEGSSE----KGIADIRA 56 (332) T ss_dssp CCCCEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT----------CCEEEEECTTCHH----HHHHHHHH T ss_pred CCccEEEEEEcCCCC------------HHHHHHHHHHHHHHHHcC----------CCEEEeeCCCCHH----HHHHHHHH Confidence 467899999997542 255677788888887753 3344455443322 22333443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIG---AAASSVSIMVANILRLFKIPQISYASTAPELSDN-TRYDFFSRVVPP 198 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg---~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~-~~~~~~~~~~~~ 198 (908) ++. +++++++. +..+.........+...++|+|..+...+..... ...++++++..+ T Consensus 57 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~~~~~~~~~~~v~~d 117 (332) T 2RJO_A 57 LLQ-------------------KTGGNLVLNVDPNDSADARVIVEACSKAGAYVTTIWNKPKDLHPWDYNPNYVAHLSYD 117 (332) T ss_dssp HHH-------------------HTTTCEEEEECCSSHHHHHHHHHHHHHHTCEEEEESCCCTTCCGGGGTTTEEEEEECC T ss_pred HHh-------------------cCCCEEEEEcCCCCcchHHHHHHHHHHcCCEEEEEcCCCCCCCcccCCCCceEEEecC Confidence 332 34565553 3222222334455667899999876544321100 012456677777 Q NP_000836.2 199 DSYQAQAMVDIVT-ALGWN-YVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-- 272 (908) Q Consensus 199 ~~~~~~~~~~~l~-~~~~~-~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-- 272 (908) +...+..+++++. +.+.+ +++++.. +...+..+.++|++.+++..++.+....... .+..+....++++++. T Consensus 118 ~~~~~~~~~~~l~~~~g~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~ 195 (332) T 2RJO_A 118 GVAYGEETATQLFKSMGGKGGVVALGGIFSNVPAIERKAGLDAALKKFPGIQLLDFQVAD--WNSQKAFPIMQAWMTRFN 195 (332) T ss_dssp HHHHHHHHHHHHHHHTTTCEEEEEEECCTTCHHHHHHHHHHHHHHHTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHHG T ss_pred hHHHHHHHHHHHHHHcCCCeEEEEEeCCCCCHHHHHHHHHHHHHHHhCCCcEEeeeEeCC--CCHHHHHHHHHHHHHHcc Confidence 7666777777764 45665 8998853 3345666777888877653124443211111 1112233445555421 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIG 307 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~ 307 (908) .++++|++.. +..+..+++++++.|+..++.+++ T Consensus 196 ~~~d~i~~~~-~~~a~~~~~a~~~~g~~~~~~i~~ 229 (332) T 2RJO_A 196 SKIKGVWAAN-DDMALGAIEALRAEGLAGQIPVTG 229 (332) T ss_dssp GGEEEEEESS-HHHHHHHHHHHHHTTCBTTBCEEC T ss_pred CccCEEEECC-HHHHHHHHHHHHHCCCCCCCCEEc Confidence 2567776654 445567778888777632333333 No 224 >4Y9T_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: MSE, PA1; 1.801A {Agrobacterium vitis} Probab=97.09 E-value=8.9e-07 Score=91.44 Aligned_cols=205 Identities=12% Similarity=0.072 Sum_probs=115.5 Template_Neff=11.000 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++..+..+++.++++.| +++.+.|...+.. ...+.++ T Consensus 24 ~~~~~~Igvi~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~l~~~~~~~~~~----~~~~~~~ 77 (346) T 4Y9T_A 24 AQTKGMVYYLVPTLLD------------EFQTGSVNALSMFLGQVG----------YEMKTLNADNKTD----AQQSQMN 77 (346) T ss_dssp --CCCEEEEEESCCCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCHH----HHHHHHH T ss_pred cCCCCEEEEEccCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEeCCCCHH----HHHHHHH Confidence 3478999999987642 255677788888777653 3444555443322 2333344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASS-VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~-~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. +++|++|+...+. ........+...++|+|..+...+. .++.+++.++.. T Consensus 78 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 132 (346) T 4Y9T_A 78 DVIA-------------------LKPAAIILAAVDFNALKPSIEAARAAGIPVVEFDRQITS------TPSDFTSVAGTV 132 (346) T ss_dssp HHHH-------------------HCCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCCS------SCCSEEEEECHH T ss_pred HHHh-------------------cCCCEEEEcCCCccchHHHHHHHHHCCCCEEEeCCCCCC------CCCceEEEeChH Confidence 4332 4678777644332 2224445566789999987764331 134556666666 Q NP_000836.2 201 YQAQAMVDIVTALGW-------NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 201 ~~~~~~~~~l~~~~~-------~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) ..++.+++++.+.+. ++++++.. +..++..+.++|++.+++..++.+....... .+..+....++++++ T Consensus 133 ~~~~~~~~~l~~~~~~~~~~~~~~i~~i~~~~~~~~~~~r~~g~~~~l~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~ 210 (346) T 4Y9T_A 133 EIGHIAGDHAISLLKGKNGDVKGKILQVPGDPGDPYTLDIQKGFEEKIKAFPGVKIISVPAVQ--WEASAAGTIVSDQML 210 (346) T ss_dssp HHHHHHHHHHHHHHBCTTSCBCEEEEEECCCTTCHHHHHHHHHHHHHHHTCTTEEEEECCCGG--GCHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHhcCCCCCceEEEEEecCCCCHHHHHHHHHHHHHHHhCCCcEEEEecCCC--CCHHHHHHHHHHHHH Confidence 667777777754333 78888875 3445667778888877653124433221111 111234445555542 Q NP_000836.2 272 T-PNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 ~-~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) . .++++|+.. .+..+..+++++++.|+. T Consensus 211 ~~~~~~~i~~~-~~~~a~~~~~al~~~g~~ 239 (346) T 4Y9T_A 211 ANPDIDLIFLH-AAHLSVAAVASLEAAGKK 239 (346) T ss_dssp HCTTCCEEEES-SHHHHHHHHHHHHHTTCC T ss_pred HCCCCCEEEEC-ChHHHHHHHHHHHHcCCC Confidence 1 245555544 344556677888877763 No 225 >4RU1_A Monosaccharide ABC transporter substrate-binding protein; SUGAR TRANSPORTER, ABC-TYPE, ENZYME FUNCTION; HET: INS, CIT; 1.5A {Acidothermus cellulolyticus} Probab=97.08 E-value=9.1e-07 Score=89.26 Aligned_cols=206 Identities=13% Similarity=0.059 Sum_probs=120.0 Template_Neff=11.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||++.|.++.. .....+..+++.++++.+ +++.+. + ..++ +...+ T Consensus 14 ~~~~~~~~~Ig~~~~~~~~~-----------~~~~~~~~~~~~~~~~~g--------~~~~~~--~-~~~~----~~~~~ 67 (304) T 4RU1_A 14 GKANTPHLTIAMITHQQPGD-----------TFWDIIRKGALAAAAKDN--------VTLKYS--N-DPDS----TKEAV 67 (304) T ss_dssp ---CCCCEEEEEEECCCTTC-----------THHHHHHHHHHHHHHHTT--------EEEEEE--E-CSSH----HHHHH T ss_pred cCCCCCCeEEEEEeCCCCCC-----------hHHHHHHHHHHHHHHHcC--------CEEEEe--C-CCCc----HHHHH Confidence 34567889999999974321 234567778888887753 333332 3 2222 22233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIG-AAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg-~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. ++++++|+ +..+.........+...++|+|..+...+.. ...++++++.+ T Consensus 68 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~---~~~~~~~~v~~ 125 (304) T 4RU1_A 68 LIQDAVN-------------------AKVDGIAVTIPDPPALIPAIKQAVAAGIPVVAFNAGIDQW---KESGALMYFGQ 125 (304) T ss_dssp HHHHHHH-------------------TTCSEEEECCSSHHHHHHHHHHHHHTTCCEEEESSCTTTH---HHHTCSEEEEC T ss_pred HHHHHHH-------------------cCCCEEEEcCCChHhhHHHHHHHHHCCCCEEEEeCCCccc---cccCCceEEec Confidence 3444432 47888887 4333333344456677899999877644321 11345677778 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLA--SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PN 274 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~--~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~ 274 (908) ++...+..+++++.+.+.++++++. .++.++..+.+++++.+++. +..+... . .+..+....++++++. .+ T Consensus 126 d~~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~---~--~~~~~~~~~~~~~l~~~~~ 199 (304) T 4RU1_A 126 DETVAGQAAGARATSEGFKHVLCVLQAQGQVQLESRCNGVQQTFKGQ-YTKLYVN---G--ADQPSVRTTIAAKLKQDPS 199 (304) T ss_dssp CHHHHHHHHHHHHHHTTCCEEEEEESSSSCHHHHHHHHHHHHHCCSE-EEEEECC---T--TCHHHHHHHHHHHHHHCTT T ss_pred CHHHHHHHHHHHHHHcCCceEEEEEcCCCcHHHHHHHHHHHHHHhcC-cceEEEc---C--CChHHHHHHHHHHHhhCCC Confidence 8777788888888777888999994 33445667777888877764 2333211 1 1112334445555431 23 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) +++|++. ++..+..+++++++.|+ T Consensus 200 ~~~i~~~-~~~~~~~~~~~~~~~g~ 223 (304) T 4RU1_A 200 IDLVITL-GAPIAQLAIQAVKDAGS 223 (304) T ss_dssp CCEEEES-SHHHHHHHHHHHHHTTC T ss_pred CCEEEEC-ChhHHHHHHHHHHHcCC Confidence 6777644 34456677888887776 No 226 >4YV7_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: MSE; 2.3A {Mycobacterium smegmatis} Probab=97.08 E-value=9.4e-07 Score=90.21 Aligned_cols=215 Identities=13% Similarity=0.046 Sum_probs=114.6 Template_Neff=11.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) ....++.++||++.|..+. ..+.....+++.++++.+ +++.+.|+..++. ...+ T Consensus 34 ~~~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~l~~~~~~~~~~----~~~~ 87 (326) T 4YV7_A 34 APVVDGALKIGFSQATQQS------------PFYVALTDAAKAEAQAQG----------DELFYADANGDIT----KQNN 87 (326) T ss_dssp -----CCCEEEEEESCCSS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCHH----HHHH T ss_pred CCccCCCcEEEEEeCCCCC------------HHHHHHHHHHHHHHHHcC----------CEEEEEcCCCCHH----HHHH Confidence 3456778999999997542 245667788888887753 3444555543322 2233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. ++++++++...+... ......+...++|+|..+...+ .++.+.+.+ T Consensus 88 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~ 141 (326) T 4YV7_A 88 DVQDLIT-------------------RGINVLVINPVDPKGVTPSLAAAEAAGIKVVTVDRPVE-------SGAASFVGR 141 (326) T ss_dssp HHHHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCEEEEESSCCS-------SCCSEEEEC T ss_pred HHHHHHH-------------------cCCCEEEEcCCCccccHHHHHHHHHCCCeEEEeCCCCC-------CCcceEEec Confidence 3443332 478877765443322 2344556678999998765432 134556666 Q NP_000836.2 198 PDSYQAQAMVDIVT----ALGWNYVSTLAS-EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE- 271 (908) Q Consensus 198 ~~~~~~~~~~~~l~----~~~~~~v~ii~~-~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~- 271 (908) ++...++.+++++. +.+.+.+.++.. ++.++..+.+++++.+++.+++.+....... .+..+....++++++ T Consensus 142 d~~~~~~~~~~~~~~~l~~~g~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~ 219 (326) T 4YV7_A 142 DNKAMGELVGKAAVDTLGPDGGKIIEIQGDAGGAVARDRRDGFQAAVSGRPNITIVEGPYCD--YIRSKAVTAMQDLLQA 219 (326) T ss_dssp CHHHHHHHHHHHHHHHHGGGCEEEEEEECCTTCHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHHCCCCcEEEEEEcCCCCHHHHHHHHHHHHHHhcCCCeEEeeccccc--CcHHHHHHHHHHHHHH Confidence 66655655444432 234444444432 3456667778888877664124433211111 111223344555542 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSD 309 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~ 309 (908) ..++|+|++.. +..+..+++++++.|.. ++.+++.+ T Consensus 220 ~~~~~~i~~~~-~~~a~~~~~~l~~~g~~-~~~i~~~~ 255 (326) T 4YV7_A 220 HPDLKGVYAQN-DDMALGAMQVLAENNRT-DVKVFGVD 255 (326) T ss_dssp CTTEEEEEESS-HHHHHHHHHHHHHTTCT-TSEEECSB T ss_pred CCCCcEEEeCC-hHHHHHHHHHHHHCCCC-CcEEEEec Confidence 13677776654 44456677888877762 34444443 No 227 >2FN9_B ribose ABC transporter, periplasmic ribose-binding; RBP, ribose binding protein, periplasmic; 1.4A {Thermotoga maritima} Probab=97.06 E-value=1e-06 Score=88.25 Aligned_cols=202 Identities=10% Similarity=0.046 Sum_probs=110.6 Template_Neff=11.700 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++.| +++.+.++..+. +...+.+++++ T Consensus 2 ~~~Ig~v~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~~~~ 55 (290) T 2FN9_B 2 KGKMAIVISTLNN------------PWFVVLAETAKQRAEQLG----------YEATIFDSQNDT----AKESAHFDAII 55 (290) T ss_dssp -CEEEEEESCSSS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHHHHHH T ss_pred CceEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCH----HHHHHHHHHHH Confidence 5689999987542 255677788888887653 233444443332 12233334333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++|....+... ......+...++|+|..+...+. ..++.+++..++...+ T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~d~~~~~ 111 (290) T 2FN9_B 56 A-------------------AGYDAIIFNPTDADGSIANVKRAKEAGIPVFCVDRGINA-----RGLAVAQIYSDNYYGG 111 (290) T ss_dssp H-------------------HTCSEEEECCSCTTTTHHHHHHHHHTTCCEEEESSCCSC-----SSSSSEEEEECHHHHH T ss_pred H-------------------cCCCEEEEcCCCCcccHHHHHHHHHCCCCEEEECCCCCC-----CCCceEEEEeCchHHH Confidence 2 477877765433322 13344566789999987764431 1234566677776677 Q NP_000836.2 204 QAMVDIVTALG------WNYVSTLA----SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-T 272 (908) Q Consensus 204 ~~~~~~l~~~~------~~~v~ii~----~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~ 272 (908) +.+++++.+.+ .++++++. .+..+...+.+++++.+++.+...+....... .+..+....+++++. . T Consensus 112 ~~~~~~l~~~~~~~~~~~~~i~~i~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~ 189 (290) T 2FN9_B 112 VLAGEYFVKFLKEKYPDAKEIPYAELLGILSAQPTWDRSNGFHSVVDQYPEFKMVAQQSAE--FDRDTAYKVTEQILQAH 189 (290) T ss_dssp HHHHHHHHHHHHHHSTTCSCEEEEEEECCTTCHHHHHHHHHHHHHHTTSTTEEEEEEEECT--TCHHHHHHHHHHHHHHC T ss_pred HHHHHHHHHHHHHHCCCccccCEEEEEeeCCCchHHHHHHHHHHHHHhCCCcEEeeeecCC--CCHHHHHHHHHHHHHHC Confidence 77777765433 26777633 23344556777777777654212222111111 111223344455542 1 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) .++|+|++. ++..+..+++++++.|+ T Consensus 190 ~~~d~i~~~-~~~~a~~~~~~l~~~g~ 215 (290) T 2FN9_B 190 PEIKAIWCG-NDAMALGAMKACEAAGR 215 (290) T ss_dssp TTCCEEEES-SHHHHHHHHHHHHHHTC T ss_pred CCCCEEEEC-ChHHHHHHHHHHHHcCC Confidence 367888766 35556778888877776 No 228 >4XXH_B PROTEIN (TREHALOSE OPERON REPRESSOR); LACI FAMILY, PHOSPHATE BINDING, PROTEIN; HET: T6P; 2.4A {Escherichia coli K-12} Probab=97.06 E-value=1e-06 Score=86.09 Aligned_cols=192 Identities=11% Similarity=0.087 Sum_probs=114.8 Template_Neff=12.100 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++.+ + ++.+.++..++. ...+.++++. T Consensus 2 ~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~~----~~~~~~~~~~ 55 (255) T 4XXH_B 2 DKVVAIIVTRLDS------------LSENLAVQTMLPAFYEQG--------Y--DPIMMESQFSPQ----LVAEHLGVLK 55 (255) T ss_dssp CCEEEEEESCTTC------------HHHHHHHHHHHHHHHHHT--------C--EEEEEECTTCHH----HHHHHHHHHH T ss_pred CeEEEEEECCCCC------------hhHHHHHHHHHHHHHHcC--------C--EEEEEeCCCCHH----HHHHHHHHHH Confidence 5789999987542 255667778887777642 2 334444433321 2223333333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . .++|++|+...+... ...+...++|+|..+... +.++++.+++...++ T Consensus 56 ~-------------------~~~d~ii~~~~~~~~---~~~~~~~~ip~v~~~~~~---------~~~~~v~~~~~~~~~ 104 (255) T 4XXH_B 56 R-------------------RNIDGVVLFGFTGIT---EEMLAHWQSSLVLLARDA---------KGFASVCYDDEGAIK 104 (255) T ss_dssp H-------------------TTCSEEEEECCTTCC---TGGGGGGTTSEEEESSCC---------TTSEEEEECHHHHHH T ss_pred h-------------------CCCCEEEEecCCCCc---HHHHHhcCCeEEEECCCC---------CCCCEEEeCHHHHHH Confidence 2 478888875544332 234566799988765422 245667777777788 Q NP_000836.2 205 AMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 205 ~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .+++++.+.+.++++++..+.. ++..+.+++++.+++. ++.+... ... .+..+....+++++. .++|+|++. T Consensus 105 ~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~-~~~--~~~~~~~~~~~~~~~-~~~dai~~~ 179 (255) T 4XXH_B 105 ILMQRLYDQGHRNISYLGVPHSDVTTGKRRHEAYLAFCKAH-KLHPVAA-LPG--LAMKQGYENVAKVIT-PETTALLCA 179 (255) T ss_dssp HHHHHHHHTTCCCEEEECCCTTSCCCCCCHHHHHHHHHHHT-TCCCCEE-CCC--SCHHHHHHHGGGGCC-TTCCEEEES T ss_pred HHHHHHHHCCCCcEEEEeCChhccccHHHHHHHHHHHHHHC-CCCCcee-cCC--CcchhHHHHHHHHhC-CCCCEEEEe Confidence 8888887678889999985433 4667778888887764 3433211 111 111123334555553 578888776 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~ 299 (908) . +..+..+++++++.|+ T Consensus 180 ~-~~~a~~~~~~~~~~g~ 196 (255) T 4XXH_B 180 T-DTLALGASKYLQEQRI 196 (255) T ss_dssp S-HHHHHHHHHHHHHTTC T ss_pred c-HHHHHHHHHHHHHCCC Confidence 4 4456677888877776 No 229 >5IX8_B Putative sugar ABC transport system; Structural Genomics, Midwest Center for; HET: EDO, SO4, MSE; 1.6A {Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)} Probab=97.04 E-value=1.1e-06 Score=89.41 Aligned_cols=208 Identities=14% Similarity=0.032 Sum_probs=120.9 Template_Neff=11.700 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVR-ILDTCSRDTYALEQSLT 118 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~-~~d~~~~~~~a~~~~~~ 118 (908) ....+.++||++.|..+. .++.....+++.++++.+ +++.+. ..|+..+. ....+ T Consensus 10 ~~~~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~~~~~~----~~~~~ 65 (321) T 5IX8_B 10 IVARQPLKLGVTVVHLLD------------NFYKGIAYGIVDEARRSN--------VEVVQVAVAGAYGNV----QQQFA 65 (321) T ss_dssp CCCCSCCEEEEEESCSSS------------SHHHHHHHHHHHHHHHHT--------CEEEEEEECSSTTCH----HHHHH T ss_pred cccCCCcEEEEEECCCCC------------HHHHHHHHHHHHHHHHCC--------CEEEEEEecCCCCCH----HHHHH Confidence 345678999999987542 255677888888888763 445543 23332332 22233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAAS-SVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s-~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. .+++++|..... .........+.+.++|+|..+...+. .++.+++.+ T Consensus 66 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~ 120 (321) T 5IX8_B 66 QLQSFKT-------------------LGVDYAVLSPAAYSGYDPVVADLARSGIKTISAGIPVNS------DKIAFGVLQ 120 (321) T ss_dssp HHHHHHH-------------------TTCSEEEECCSSSSSCHHHHHHHHHTTCEEEEESSCCSC------TTCCEEEEC T ss_pred HHHHHHH-------------------cCCCEEEEcCCCccccHHHHHHHHHCCCEEEEECCCCCC------CcceEEEEc Confidence 3444332 467776654332 22234445666789999987654321 245667777 Q NP_000836.2 198 PDSYQAQAMVDIVTALGW--NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET- 272 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~--~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~- 272 (908) ++...+..+++++.+.+. ++++++.. ++.++..+.+++++.+++. ++.+.... .....+..+....++++++. T Consensus 121 d~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~-~~~~~~~~~~~~~~~~~~~~~ 198 (321) T 5IX8_B 121 DDTLIGKVLGKALCDDGAQGKQVIVVPGAAGLEWPRLRYEGFKEVASAC-GAKLTPAA-FRGEMSLADGMAQTQDLLMRT 198 (321) T ss_dssp CHHHHHHHHHHHHHHTTCTTCEEEECCCCSSSSHHHHHHHHHHHHHHHT-TCEECCCC-CCSCCCHHHHHHHHHHHHHHC T ss_pred CHHHHHHHHHHHHHHccCCCcEEEEEeCCCCCcHHHHHHHHHHHHHHhc-CCEEEeee-ecCCCCHHHHHHHHHHHHHhC Confidence 777778888888765554 48888875 4456677888888888765 34443211 11001122344445555421 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) .++++|+... +..+..+++++++.|+ T Consensus 199 ~~~~~i~~~~-~~~a~~~~~~~~~~g~ 224 (321) T 5IX8_B 199 PDAEYVFTPV-TFLGIGAVRAARQANR 224 (321) T ss_dssp TTEEEEECSS-HHHHHHHHHHHHHTTC T ss_pred CCCCEEEeCC-hHHHHHHHHHHHHcCC Confidence 2355565543 4455667888887776 No 230 >4WUT_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: FCB, MSE; 1.5A {Agrobacterium vitis} Probab=97.04 E-value=1.1e-06 Score=89.04 Aligned_cols=222 Identities=9% Similarity=0.031 Sum_probs=119.1 Template_Neff=11.600 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) ....++..+||++.|..+. .+...+..+++.++++.+. ..+.+...|...++ +...+ T Consensus 17 ~l~~~~~~~I~vi~~~~~~------------~~~~~~~~~~~~~~~~~g~-------~~~~~~~~~~~~~~----~~~~~ 73 (313) T 4WUT_A 17 NLYFQSMGEIAVIVKTVNS------------TFWQNVQKGADAAIGKQKA-------HTITFQGPAAESAI----ADQVN 73 (313) T ss_dssp -------CEEEEECSCSSC------------HHHHHHHHHHHHHHTTCSS-------CEEEEECCSSTTCH----HHHHH T ss_pred cccccCCcEEEEEECCCCC------------HHHHHHHHHHHHHHHhcCc-------eEEEEeCCcccccH----HHHHH Confidence 3456678999999987542 2456777888888877542 11223222222221 12233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. +++|++|........ ......+...++|+|..+...+.. ....+++.+.+ T Consensus 74 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~---~~~~~~~~v~~ 131 (313) T 4WUT_A 74 MVENAVN-------------------RKVDAILLAPSDPDALVPAVKKAWEARIPVVIIDSMLSKD---AEKYYQAFLAT 131 (313) T ss_dssp HHHHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCCGG---GGGGCSEEEEC T ss_pred HHHHHHh-------------------CCCCEEEECCCCHHhhHHHHHHHHHCCCCEEEEeCCCCcc---hhhheEEEEEC Confidence 3443332 478877764433222 233445667899999887644321 01134567777 Q NP_000836.2 198 PDSYQAQAMVDIVTALGW--NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-T 272 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~--~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~ 272 (908) ++...++.+++++.+.+. ++++++.. +...+..+.+++++.+++.+...+....... .+..+....+++++. . T Consensus 132 d~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~r~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~ 209 (313) T 4WUT_A 132 DNKAAGELAAKAMIQKVGTEGKIAVMSYVAGAGSEIGRVGGFTDYIKANSKLQIVGPYYSQ--SQMATALNQTTDVLAAN 209 (313) T ss_dssp CHHHHHHHHHHHHHHHHCSSSEEEEEESSTTCHHHHHHHHHHHHHHHHHCCCEEEEEEECT--TCHHHHHHHHHHHHHHC T ss_pred CHHHHHHHHHHHHHHHHCCCeEEEEEEccCCChhHHHHHHHHHHHHHHcCCcEEEeccCCc--ccHHHHHHHHHHHHHHC Confidence 777778888888866555 78998875 3345556778888887765312332211111 111223333444432 1 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) .++++|++.. +..+..+++++++.|...++.+++. T Consensus 210 ~~~~~i~~~~-~~~a~~~~~al~~~g~~~~i~i~~~ 244 (313) T 4WUT_A 210 ADLKGIFGAN-EPTAIGMGRAIKQAGKAGKLVAIGF 244 (313) T ss_dssp TTCCEEEECS-HHHHHHHHHHHHHTTCTTSSEEEEE T ss_pred CCCCEEEEcC-hhHHHHHHHHHHHcCCCCCEEEEEe Confidence 3567777664 4455677888887776323444443 No 231 >3HCW_A Maltose operon transcriptional repressor; RNA-BINDING, TRANSCRIPTIONAL REPRESSOR, PSI-2, NYSGXRC; HET: GOL; 2.2A {Staphylococcus aureus subsp. aureus Mu50} Probab=97.03 E-value=1.2e-06 Score=87.99 Aligned_cols=207 Identities=11% Similarity=0.084 Sum_probs=118.8 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++..+||++.|.++.... ...+......+++.++++. |+ ++.+.+...+. +...+.++ T Consensus 4 ~~~~~~I~~v~~~~~~~~~-------~~~~~~~~~~g~~~~~~~~--------g~--~~~~~~~~~~~----~~~~~~~~ 62 (295) T 3HCW_A 4 TNQTYKIGLVLKGSEEPIR-------LNPFYINVLLGISETCNQH--------GY--GTQTTVSNNMN----DLMDEVYK 62 (295) T ss_dssp CCCSCEEEEECSCCCHHHH-------SCHHHHHHHHHHHHHHHTT--------TC--EEEECCCCSHH----HHHHHHHH T ss_pred cCCccEEEEEecCCCCccc-------cChHHHHHHHHHHHHHHHh--------CC--EEEEEecCCCc----hhHHHHHH Confidence 4578899999987431000 0124556677777776653 23 33344433321 12223333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) .++. .++|++|+...+.. ..+...+...++|+|..+...+. ..+.++.+.+++.. T Consensus 63 ~~~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~d~~~ 117 (295) T 3HCW_A 63 MIKQ-------------------RMVDAFILLYSKEN-DPIKQMLIDESMPFIVIGKPTSD-----IDHQFTHIDNDNIL 117 (295) T ss_dssp HHHT-------------------TCCSEEEESCCCTT-CHHHHHHHHTTCCEEEESCCCSS-----GGGGSCEEEECHHH T ss_pred HHHH-------------------cCCCEEEEeCCCCC-CHHHHHHHHCCCCEEEECCCCCc-----ccccCCEEecChHH Confidence 3332 47888887544433 34455667789999988754321 12345667777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL----ETPNA 275 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~----~~~~~ 275 (908) .++.+++++.+.+.++++++..+. ..+..+.++|++.+++. ++.+... ... .+..+....+++++ ...++ T Consensus 118 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~l~~~-~~~~~~~-~~~--~~~~~~~~~~~~~~~~~~~~~~~ 193 (295) T 3HCW_A 118 ASENLTRHVIEQGVDELIFITEKGNFEVSKDRIQGFETVASQF-NLDYQII-ETS--NEREVILNYMQNLHTRLKDPNIK 193 (295) T ss_dssp HHHHHHHHHHHHCCSEEEEEEESSCCHHHHHHHHHHHHHHHHT-TCEEEEE-EEC--SCHHHHHHHHHHHHHHHTCTTSC T ss_pred HHHHHHHHHHHcCCCEEEEEeCCCCChhHHHHHHHHHHHHHHC-CCCceEE-ecC--CCHHHHHHHHHHHHHHhcCCCCC Confidence 888888888767888999988543 25566778888888765 3443211 111 11122333344432 12346 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) |+|++.. +..+..+++++++.|+ T Consensus 194 d~i~~~~-~~~~~~~~~~l~~~g~ 216 (295) T 3HCW_A 194 QAIISLD-AMLHLAILSVLYELNI 216 (295) T ss_dssp EEEEESS-HHHHHHHHHHHHHTTC T ss_pred cEEEECC-HHHHHHHHHHHHHCCC Confidence 7777664 4456678888888776 No 232 >1JYE_A Lactose Operon Repressor; Gene Regulation, Protein Stability, Protein; 1.7A {Escherichia coli} SCOP: c.93.1.1 Probab=97.02 E-value=1.2e-06 Score=90.41 Aligned_cols=203 Identities=13% Similarity=0.080 Sum_probs=115.3 Template_Neff=11.300 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++..+..+++.++++.+ +++.+...+. .++ +...+.++ T Consensus 58 ~~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~~~~~~~~ 112 (349) T 1JYE_A 58 GKQSLLIGVATSSLAL------------HAPSQIVAAILSRADQLG--------ASVVVSMVER-SGV----EACKTAVH 112 (349) T ss_dssp ----CEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------CEEEEEECCS-SSH----HHHHHHHH T ss_pred cCCCcEEEEEeCCccC------------ccHHHHHHHHHHHHHHcC--------CEEEEEecCC-ChH----HHHHHHHH Confidence 4578899999987542 255677788888887653 3333322221 121 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+.........+...++|+|..+...+ +.+..+..+... T Consensus 113 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~--------~~~~~v~~d~~~ 165 (349) T 1JYE_A 113 NLLA-------------------QRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQ--------TPINSIIFSHED 165 (349) T ss_dssp HHHT-------------------TTCSCEEEESCCCHHHHHHHHHHTTTSCEEESSSCTT--------SSSCEEEECHHH T ss_pred HHHh-------------------cCCCEEEEeCCCCcHHHHHHHHHhcCCCEEEEeCCCC--------CCCCEEEEccHH Confidence 4332 4788888764443322222345678999998765322 234455666666 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .+..+++++.+.++++++++.. +..+...+.++|++.+++. ++.+....... .+..+....+++++. ..++++| T Consensus 166 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~l~~~-~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~~i 242 (349) T 1JYE_A 166 GTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRN-QIQPIAEREGD--WSAMSGFQQTMQMLNEGIVPTAM 242 (349) T ss_dssp HHHHHHHHHHHHTCCSEEEEECCTTSHHHHHHHHHHHHHHHHT-TCCCSEEEECC--SSHHHHHHHHHHHHHTTCCCSEE T ss_pred HHHHHHHHHHHCCCCcEEEEeCCcccHHHHHHHHHHHHHHHHC-CCCCceeeecC--CChhHHHHHHHHHHhcCCCCCEE Confidence 6777788876668899999985 3345667788888888775 35443211111 111223334455542 1347777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 243 ~~~~-d~~a~~~~~~l~~~g~~ 263 (349) T 1JYE_A 243 LVAN-DQMALGAMRAITESGLR 263 (349) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EEcC-HHHHHHHHHHHHHcCCC Confidence 6654 44566778888887764 No 233 >2PE5_B Lactose operon repressor/DNA Complex; Lac repressor, allosteric effectors, gene; HET: 145; 3.5A {Escherichia coli} SCOP: a.35.1.5, c.93.1.1 Probab=97.02 E-value=1.3e-06 Score=89.42 Aligned_cols=203 Identities=12% Similarity=0.060 Sum_probs=116.8 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++..+..+++.++++.+ +++.+...+. .++ +...+.++ T Consensus 57 ~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~~~~~~~~ 111 (330) T 2PE5_B 57 GKQLLLIGVATSSLAL------------HAPSQIVAAIKSRADQLG--------ASVVVSMVER-SGV----EACKAAVH 111 (330) T ss_dssp TCCCEEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------EEEEEEECCS-CSH----HHHHHHHH T ss_pred hCCCCEEEEEeCCCCC------------ccHHHHHHHHHHHHHHcC--------CEEEEEecCC-CcH----HHHHHHHH Confidence 3568899999987542 245677888888887753 3444433332 221 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+.........+...++|+|..+...+ +.++.+..+... T Consensus 112 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~--------~~~~~v~~d~~~ 164 (330) T 2PE5_B 112 NLLA-------------------QRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQ--------TPINSIIFSHED 164 (330) T ss_dssp HHHH-------------------TTCSEEEEESCCCHHHHHHHHHHSCSSCEEESSSCSS--------SSSCEEEECHHH T ss_pred HHHh-------------------CCCCEEEEeCCCCcHHHHHHHHHhcCCCEEEEcCCCC--------CCCCEEEEccHH Confidence 3332 4788888754433322222234578999998765422 234455566666 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .+..+++++.+.++++++++.. ++.....+.++|++.+++. ++.+....... .+..+....+.+++. ..++++| T Consensus 165 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~~i 241 (330) T 2PE5_B 165 GTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRN-QIQPIAEREGD--WSAMSGFQQTMQMLNEGIVPTAM 241 (330) T ss_dssp HHHHHHHHHHHHTCCSEEEEECCTTSHHHHHHHHHHHHHHHTT-TCCCSCEEECC--SCHHHHHHHHHHHHHHTCCCSEE T ss_pred HHHHHHHHHHHCCCCcEEEEeCCcccccHHHHHHHHHHHHHHC-CCCCceeeeCC--CchhHHHHHHHHHHhcCCCCCEE Confidence 6777778776668889999985 3345566778888888775 34433211111 111122333444442 1247777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|.. T Consensus 242 ~~~~-~~~a~~~~~~l~~~g~~ 262 (330) T 2PE5_B 242 LVAN-DQMALGAMRAITESGLR 262 (330) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EEcC-HHHHHHHHHHHHHCCCC Confidence 6664 44566778888877764 No 234 >3C3K_B Alanine racemase (E.C.5.1.1.1); STRUCTURAL GENOMICS, PROTEIN STRUCTURE INITIATIVE; HET: GOL; 1.99A {Actinobacillus succinogenes} Probab=97.01 E-value=1.3e-06 Score=87.08 Aligned_cols=203 Identities=14% Similarity=0.060 Sum_probs=115.2 Template_Neff=11.800 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..+++.+||++.|.... .++.....+++.++++.+ + ++.+.+...+. ....+.+ T Consensus 4 ~~~~~~~I~~~~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~ 57 (285) T 3C3K_B 4 RTAKTGMLLVMVSNIAN------------PFCAAVVKGIEKTAEKNG--------Y--RILLCNTESDL----ARSRSCL 57 (285) T ss_dssp ---CCEEEEEEESCTTS------------HHHHHHHHHHHHHHHTTT--------E--EEEEEECTTCH----HHHHHHT T ss_pred ccCCCceEEEEecCCCc------------HHHHHHHHHHHHHHHHcC--------C--EEEEEeCCCCH----HHHHHHH Confidence 34567899999984321 355677888888887753 2 33444443332 1222333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +.+.. .++|++|+...+.....+ ..+.. ++|+|..+...+ .+..+.+.+++. T Consensus 58 ~~~~~-------------------~~~d~ii~~~~~~~~~~~-~~~~~-~ip~v~~~~~~~-------~~~~~~v~~d~~ 109 (285) T 3C3K_B 58 TLLSG-------------------KMVDGVITMDALSELPEL-QNIIG-AFPWVQCAEYDP-------LSTVSSVSIDDV 109 (285) T ss_dssp HHHHT-------------------TSCSCEEECSCGGGHHHH-HHHHT-TSCEEEESCCCT-------TCSSEEEECCHH T ss_pred HHHhc-------------------CCCCEEEEecCCCCcHHH-HHHHh-cCCEEEeCCCCC-------CCCCcEEEeCcH Confidence 33322 478888876544332222 22333 899888765432 134566777777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASE--GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~--~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) ..++.+++++.+.+.++++++..+ ......+.++|++.+++. ++.+....... ..+..+....+++++. ..++++ T Consensus 110 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~-~~~~~~~~~~~~~~l~~~~~~~~ 187 (285) T 3C3K_B 110 AASEYVVDQLVKSGKKRIALINHDLAYQYAQHRESGYLNRLKFH-GLDYSRISYAE-NLDYMAGKLATFSLLKSAVKPDA 187 (285) T ss_dssp HHHHHHHHHHHHTTCCCEEEEECCTTSHHHHHHHHHHHHHHHHT-TCCCCEEEECS-SSSHHHHHHHHHHHHSSSSCCSE T ss_pred HHHHHHHHHHHHCCCCcEEEEecCccchhHHHHHHHHHHHHHHC-CCCCCceeecC-CCchHHHHHHHHHHHhcCCCCCE Confidence 777788888766678899999853 334566778888887765 34433211110 0111223333444432 134777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 188 i~~~~-~~~a~~~~~al~~~g~~ 209 (285) T 3C3K_B 188 IFAIS-DVLAAGAIQALTESGLS 209 (285) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-hHHHHHHHHHHHHCCCC Confidence 76664 44567788888887764 No 235 >8ABP_A L-ARABINOSE-BINDING PROTEIN (MUTANT WITH MET; BINDING PROTEINS; HET: GAL, GLA; 1.49A {Escherichia coli} SCOP: c.93.1.1 Probab=97.01 E-value=1.3e-06 Score=88.08 Aligned_cols=214 Identities=12% Similarity=0.073 Sum_probs=115.1 Template_Neff=11.900 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++.+ +++.+.++ .++ +...+.+++++ T Consensus 2 ~~~Ig~~~~~~~~------------~~~~~~~~~~~~~~~~~~----------~~~~~~~~-~~~----~~~~~~~~~l~ 54 (306) T 8ABP_A 2 NLKLGFLVKQPEE------------PWFQTEWKFADKAGKDLG----------FEVIKIAV-PDG----EKTLNAIDSLA 54 (306) T ss_dssp CEEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT----------EEEEEEEC-CSH----HHHHHHHHHHH T ss_pred CeEEEEEECCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEeC-CCH----HHHHHHHHHHH Confidence 5789999987542 245667788888877652 33344444 232 22233344433 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIG-AAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg-~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . ++++++|. +..+.........+...++|+|..+...+.... ...++++++.+++...+ T Consensus 55 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~-~~~~~~~~v~~d~~~~~ 114 (306) T 8ABP_A 55 A-------------------SGAKGFVICTPDPKLGSAIVAKARGYDMKVIAVDDQFVNAKG-KPMDTVPLVMLAATKIG 114 (306) T ss_dssp H-------------------TTCCEEEEECSCGGGHHHHHHHHHHTTCEEEEESSCCBCTTS-CBCTTSCEEEECHHHHH T ss_pred H-------------------cCCCEEEEeCCCcchhHHHHHHHHhCCCEEEEEccccccCCC-CCcccccEEeechhHHH Confidence 2 46786554 333332234445667789999988765432211 11345677777777777 Q NP_000836.2 204 QAMVDIVTA----LGWN--YVSTLASE---GNYGESGVEAFTQISREIG--GVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 204 ~~~~~~l~~----~~~~--~v~ii~~~---~~~~~~~~~~~~~~~~~~~--~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) +.+++++.+ .+++ +++++..+ ..++..+.++|++.+++.+ ..++....... .+..+....++++++ T Consensus 115 ~~~~~~l~~~~~~~g~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~- 191 (306) T 8ABP_A 115 ERQGQELYKEMQKRGWDVKESAVMAITANELDTARRRTTGSMDALKAAGFPEKQIYQVPTKS--NDIPGAFDAANSMLV- 191 (306) T ss_dssp HHHHHHHHHHHHHHTCCGGGEEEEEEECTTSHHHHHHHHHHHHHHHHHTCCGGGEEEEECSS--SSHHHHHHHHHHHHT- T ss_pred HHHHHHHHHHHHHcCCCcccceEEEEecCCChHHHHHHHHHHHHHHHcCCCcceeeeecCCC--CChhHHHHHHHHHHH- Confidence 777776643 3555 66666532 2455567778887777642 02222111111 111233444555543 Q NP_000836.2 273 PNARA---VIMFANEDDIRRILEAAKKLNQS-GHFLWIGS 308 (908) Q Consensus 273 ~~~~v---iv~~~~~~~~~~~l~~~~~~g~~-~~~~~i~~ 308 (908) .+++. ++++.++..+..+++++++.|+. .++.+++. T Consensus 192 ~~~~~~~~~i~~~~~~~a~~~~~~~~~~g~~~~~i~i~~~ 231 (306) T 8ABP_A 192 QHPEVKHWLIVGMNDSTVLGGVRATEGQGFKAADIIGIGI 231 (306) T ss_dssp TCTTCSEEEEECSSHHHHHHHHHHHHHTTCCGGGEEEEEE T ss_pred HCCCCceEEEEEcchhhHHHHHHHHHhCCCCHhcEEEEEe Confidence 23443 33444455567788888888764 13444443 No 236 >5ABP_A L-ARABINOSE-BINDING PROTEIN COMPLEX WITH D-GALACTOSE; BINDING PROTEIN; HET: GAL, GLA; 1.8A {Escherichia coli} SCOP: c.93.1.1 Probab=97.01 E-value=1.3e-06 Score=88.06 Aligned_cols=214 Identities=12% Similarity=0.076 Sum_probs=114.6 Template_Neff=11.900 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++.+ +++.+.+. .++ ....+.+++++ T Consensus 2 ~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~-~~~----~~~~~~~~~l~ 54 (306) T 5ABP_A 2 NLKLGFLVKQPEE------------PWFQTEWKFADKAGKDLG----------FEVIKIAV-PDG----EKTLNAIDSLA 54 (306) T ss_dssp CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT----------CEEEEEEC-CSH----HHHHHHHHHHH T ss_pred CcEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEeC-CCH----HHHHHHHHHHH Confidence 5789999987542 255677788888877652 23333443 232 22233444443 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVI-GAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . ++++++| ++..+.........+...++|+|.++...+.... ...++++++.+++...+ T Consensus 55 ~-------------------~~~d~iii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~-~~~~~~~~v~~d~~~~~ 114 (306) T 5ABP_A 55 A-------------------SGAKGFVICTPDPKLGSAIVAKARGYDMKVIAVDDQFVNAKG-KPMDTVPLVMMAATKIG 114 (306) T ss_dssp H-------------------TTCCEEEEECSCGGGHHHHHHHHHHTTCEEEEESSCCBCTTS-CBCTTSCEEEECHHHHH T ss_pred H-------------------CCCCEEEEeCCCcchHHHHHHHHHhCCCEEEEEcCccccCCC-CCCccceEeeechhHHH Confidence 2 4677544 4444333334455667789999988765432111 01235677777776667 Q NP_000836.2 204 QAMVDIVTA----LGWN--YVSTLASE---GNYGESGVEAFTQISREIG--GVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 204 ~~~~~~l~~----~~~~--~v~ii~~~---~~~~~~~~~~~~~~~~~~~--~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) +.+++++.+ .+++ ++.++..+ ..++..+.+++++.+++.+ ..++....... .+..+....++++++ T Consensus 115 ~~~~~~l~~~~~~~g~~~~~i~v~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~--~~~~~~~~~~~~~l~- 191 (306) T 5ABP_A 115 ERQGQELYKEMQKRGWDVKESAVMAITANELDTARRRTTGSMDALKAAGFPEKQIYQVPTKS--NDIPGAFDAANSMLV- 191 (306) T ss_dssp HHHHHHHHHHHHHTTCCGGGEEEEEEECTTSHHHHHHHHHHHHHHHHTTCCGGGEEEEECSS--SSHHHHHHHHHHHHT- T ss_pred HHHHHHHHHHHHHcCCCccccEEEEEEcCCChHHHHHHHHHHHHHHHcCCCCceeEecCCCC--CChHHHHHHHHHHHH- Confidence 777766533 3555 76666532 2455667778888777642 02222111111 112234455566553 Q NP_000836.2 273 PNARA---VIMFANEDDIRRILEAAKKLNQS-GHFLWIGS 308 (908) Q Consensus 273 ~~~~v---iv~~~~~~~~~~~l~~~~~~g~~-~~~~~i~~ 308 (908) .+++. ++++.++..+..+++++++.|+. .++.+++. T Consensus 192 ~~~~~~~~~i~~~~~~~a~~~~~~~~~~g~~~~~i~v~~~ 231 (306) T 5ABP_A 192 QHPEVKHWLIVGMNDSTVLGGVRATEGQGFKAADIIGIGI 231 (306) T ss_dssp TCTTCCEEEEECSSHHHHHHHHHHHHHTTCCGGGEEEEEE T ss_pred HCCCCceEEEEEechHHHHHHHHHHHhCCCChhcEEEEEe Confidence 23443 23333444567788888887764 13344443 No 237 >4KVF_A Rhamnose ABC transporter, periplasmic rhamnose-binding; structural genomics, PSI-Biology, Protein Structure; HET: GOL; 1.722A {Kribbella flavida} Probab=96.99 E-value=1.5e-06 Score=89.53 Aligned_cols=217 Identities=11% Similarity=0.057 Sum_probs=118.1 Template_Neff=11.400 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....+.++||++.|..+. .++.....+++.++++.| +++.+...+. .++ ....+ T Consensus 33 ~~~~~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~a~~~~~--------~~v~~~~~~~-~~~----~~~~~ 87 (342) T 4KVF_A 33 NAPLKEGLKIAYLPKQLNN------------PYTDVEVGGGKVAVGEIK--------GEYKLVGPND-ASA----SSQVS 87 (342) T ss_dssp TSCCCSSCEEEEECSSSSS------------HHHHHHHHHHHHHHHHTT--------CEEEECCCCT-TCC----CCHHH T ss_pred CCCccCCeEEEEEcCCCCC------------hHHHHHHHHHHHHHHHhC--------CEEEEECCCC-CCH----HHHHH Confidence 3455678999999986542 245667788888888764 2344443332 221 12233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIG-AAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg-~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. ++++++|+ +..+.........+...++|+|..+...+. ..++.+.... T Consensus 88 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~v~~~ 143 (342) T 4KVF_A 88 YINTLIQ-------------------QQQDVIVVAANDPNAVCPSLNQARKADIKVVTFDSDAAK-----TCRDAFINQA 143 (342) T ss_dssp HHHHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCEEEEESSCCCG-----GGCSEEEESS T ss_pred HHHHHHH-------------------cCCCEEEEcCCCHHhhHHHHHHHHHCCCEEEEECCCCcc-----cccceEeeCC Confidence 3444332 47888887 333333334445566789999987654331 1122233222 Q NP_000836.2 198 PDSYQAQAMVDIVTALG--WNYVSTLAS--EGNYGESGVEAFTQISREI--GGVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~--~~~v~ii~~--~~~~~~~~~~~~~~~~~~~--~~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) +....++.+++++.+.+ .++++++.. ++.+...+.++|++.+++. .++++....... .+..+....++++++ T Consensus 144 ~~~~~~~~~~~~l~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~ 221 (342) T 4KVF_A 144 TTQGIGESLVKMAKELAGGSGEIAVLSATPNATNQNSWIEVMKTELAKPENAKLKLVKIAYGN--DDDQKSFTEAQGLLQ 221 (342) T ss_dssp CHHHHHHHHHHHHHHHTTTCEEEEEEESCTTCHHHHHHHHHHHHHHTSGGGTTEEEEEEEECT--TCHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHhCCCcEEEEEECCCCchhHHHHHHHHHHHHcCcccCCcEEEEEeeCC--CCHHHHHHHHHHHHH Confidence 22446677777775533 688999874 3345566777887777642 123332211111 112234445555553 Q NP_000836.2 272 T-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIG 307 (908) Q Consensus 272 ~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~ 307 (908) . .++++|++.. +..+..+++++++.++..++.+++ T Consensus 222 ~~~~~~~i~~~~-~~~~~~~~~~~~~~g~~~~v~i~~ 257 (342) T 4KVF_A 222 SYPNLKVIVSPT-TVGIAAASRYVSASSYKGKVAITG 257 (342) T ss_dssp HCTTEEEEEECS-HHHHHHHHHHHHTSTTTTTSEEEE T ss_pred HCCCccEEEEcC-hhHHHHHHHHHHHcCCCCceEEEE Confidence 1 2456666553 345566777777777632333443 No 238 >3EDC_D Lactose operon repressor; Lac-repressor, allosteric, tetramer, DNA-binding, Repressor; HET: HEZ; 2.1A {Escherichia coli K12} Probab=96.98 E-value=1.5e-06 Score=90.23 Aligned_cols=204 Identities=12% Similarity=0.068 Sum_probs=115.8 Template_Neff=11.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...+.++||++.|..+. .++..+.++++.++++.+ +++.+...+. .++ +...+.+ T Consensus 57 ~~~~~~~I~~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~~~~~~~ 111 (360) T 3EDC_D 57 AGKQSLLIGVATSSLAL------------HAPSQIVAAIKSRADQLG--------ASVVVSMVER-SGV----EACKAAV 111 (360) T ss_dssp ----CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT--------CEEEEEECCT-TCH----HHHHHHH T ss_pred ccCCCCEEEEEeCCccC------------ccHHHHHHHHHHHHHHcC--------CEEEEEecCC-ChH----HHHHHHH Confidence 34578899999987542 255677788888887753 3444433332 221 1223334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. +++|++|+...+.........+...++|+|..+...+ +.++.+..+.. T Consensus 112 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~--------~~~~~v~~d~~ 164 (360) T 3EDC_D 112 HNLLA-------------------QRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQ--------TPINSIIFSHE 164 (360) T ss_dssp HHHHH-------------------TTCSEEEEESCCCHHHHHHHHHHTTTSCEEESSSCTT--------SSSCEEEECHH T ss_pred HHHHH-------------------CCCCEEEEeCCCCcHHHHHHHHHhcCCCEEEEcCCCC--------CCCCEEEEccH Confidence 43332 4788888764443322222235678999998765432 23455666666 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ..+..+++++.+.+.++++++.. ++.....+.++|++.+++. ++.+....... .+.......+++++.. .++|+ T Consensus 165 ~~~~~~~~~l~~~g~~~i~~l~~~~~~~~~~~r~~g~~~~l~~~-~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~d~ 241 (360) T 3EDC_D 165 DGTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRN-QIQPIAEREGD--WSAMSGFQQTMQMLNEGIVPTA 241 (360) T ss_dssp HHHHHHHHHHHHHTCCCEEEEECCTTSHHHHHHHHHHHHHHHHT-TCCCSEEEECC--SSHHHHHHHHHHHHHTTCCCSE T ss_pred HHHHHHHHHHHHCCCCcEEEEeCCcccccHHHHHHHHHHHHHHC-CCCCceeeecC--CChhhHHHHHHHHHhcCCCCCE Confidence 66777777776667889999885 3445667788888888775 34443211111 1111223344444421 24777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 242 i~~~~-~~~a~~~~~~l~~~g~~ 263 (360) T 3EDC_D 242 MLVAN-DQMALGAMRAITESGLR 263 (360) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 76654 44566777888877764 No 239 >3KJX_D Transcriptional regulator, LacI family; Transcriptional regulator, Lacl family, Protein; 2.33A {Silicibacter pomeroyi} Probab=96.97 E-value=1.6e-06 Score=89.40 Aligned_cols=204 Identities=12% Similarity=0.070 Sum_probs=117.7 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+..+||++.|..+. .+...+..+++.++++.+ + ++.+.+...++ +...+.++ T Consensus 65 ~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~l~ 118 (344) T 3KJX_D 65 SNRVNLVAVIIPSLSN------------MVFPEVLTGINQVLEDTE--------L--QPVVGVTDYLP----EKEEKVLY 118 (344) T ss_dssp SSCCSEEEEEESCSSS------------SSHHHHHHHHHHHHTTSS--------C--EEEEEECTTCH----HHHHHHHH T ss_pred hCCCCeEEEEecCccc------------chHHHHHHHHHHHHHHcC--------C--EEEEEeCCCCH----HHHHHHHH Confidence 3567899999986532 245567778777776642 2 33344433332 22233444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+....... .....+...++|+|..+.... .+..+.+..++.. T Consensus 119 ~l~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 171 (344) T 3KJX_D 119 EMLS-------------------WRPSGVIIAGLEHSE-AARAMLDAAGIPVVEIMDSDG-------KPVDAMVGISHRR 171 (344) T ss_dssp HHHT-------------------TCCSEEEEECSCCCS-HHHHHHHTCSSCEEEEEECSS-------CCSSCEEEECHHH T ss_pred HHHh-------------------cCCCEEEEeCCCCCH-HHHHHHHHcCCCEEEEeCCCC-------CCcCceeEechHH Confidence 4332 467888765433322 344556678999998765321 2345566777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEG---NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~---~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) .++.+++++.+.+.++++++.... .....+.++|++.+++. ++.+..........+..+....++++++. .++++ T Consensus 172 ~g~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ 250 (344) T 3KJX_D 172 AGREMAQAILKAGYRRIGFMGTKMPLDYRARKRFEGFTEVLGKN-GVEIEDREFYSGGSALAKGREMTQAMLERSPDLDF 250 (344) T ss_dssp HHHHHHHHHHHTTCCSEEEEESSTTTCHHHHHHHHHHHHHHHHT-TCCCSEEEECCSCCCHHHHHHHHHHHHHHCTTCCE T ss_pred HHHHHHHHHHHcCCCcEEEEccCCCCChHHHHHHHHHHHHHHHC-CCCcCcceeecCCCcHHHHHHHHHHHHHhCCCCCE Confidence 788888888766888999988543 35566778888888775 34443211111011112233445555421 24666 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|.. T Consensus 251 i~~~~-~~~a~~~~~~l~~~g~~ 272 (344) T 3KJX_D 251 LYYSN-DMIAAGGLLYLLEQGID 272 (344) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 66553 44566777788777763 No 240 >3KJX_C Transcriptional regulator, LacI family; Transcriptional regulator, Lacl family, Protein; HET: MSE; 2.33A {Silicibacter pomeroyi} Probab=96.97 E-value=1.6e-06 Score=89.40 Aligned_cols=204 Identities=12% Similarity=0.070 Sum_probs=117.7 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+..+||++.|..+. .+...+..+++.++++.+ + ++.+.+...++ +...+.++ T Consensus 65 ~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~l~ 118 (344) T 3KJX_C 65 SNRVNLVAVIIPSLSN------------MVFPEVLTGINQVLEDTE--------L--QPVVGVTDYLP----EKEEKVLY 118 (344) T ss_dssp SSCCSEEEEEESCSSS------------SSHHHHHHHHHHHHHTSS--------C--EEEEEECTTCH----HHHHHHHH T ss_pred hCCCCeEEEEecCccc------------chHHHHHHHHHHHHHHcC--------C--EEEEEeCCCCH----HHHHHHHH Confidence 3567899999986532 245567778777776642 2 33344433332 22233444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+....... .....+...++|+|..+.... .+..+.+..++.. T Consensus 119 ~l~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 171 (344) T 3KJX_C 119 EMLS-------------------WRPSGVIIAGLEHSE-AARAMLDAAGIPVVEIMDSDG-------KPVDAMVGISHRR 171 (344) T ss_dssp HHHT-------------------TCCSEEEEECSCCCH-HHHHHHHHCSSCEEEEEECTT-------CCSSEEEEECHHH T ss_pred HHHh-------------------cCCCEEEEeCCCCCH-HHHHHHHHcCCCEEEEeCCCC-------CCcCceeEechHH Confidence 4332 467888765433322 344556678999998765321 2345566777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEG---NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~---~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) .++.+++++.+.+.++++++.... .....+.++|++.+++. ++.+..........+..+....++++++. .++++ T Consensus 172 ~g~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ 250 (344) T 3KJX_C 172 AGREMAQAILKAGYRRIGFMGTKMPLDYRARKRFEGFTEVLGKN-GVEIEDREFYSGGSALAKGREMTQAMLERSPDLDF 250 (344) T ss_dssp HHHHHHHHHHTTTCCSEEEECCSTTTCHHHHHHHHHHHHHHHTT-TCCEEEEECCSSCCCHHHHHHHHHHHHHHCTTCCE T ss_pred HHHHHHHHHHHcCCCcEEEEccCCCCChHHHHHHHHHHHHHHHC-CCCcCcceeecCCCcHHHHHHHHHHHHHhCCCCCE Confidence 788888888766888999988543 35566778888888775 34443211111011112233445555421 24666 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|.. T Consensus 251 i~~~~-~~~a~~~~~~l~~~g~~ 272 (344) T 3KJX_C 251 LYYSN-DMIAAGGLLYLLEQGID 272 (344) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 66553 44566777788777763 No 241 >1GLG_A GALACTOSE/GLUCOSE-BINDING PROTEIN COMPLEXED WITH D-GALACTOSE; GALACTOSE-BINDING PROTEIN; HET: GAL; 2.0A {Escherichia coli} SCOP: c.93.1.1 Probab=96.97 E-value=1.6e-06 Score=87.65 Aligned_cols=217 Identities=13% Similarity=0.037 Sum_probs=117.0 Template_Neff=11.900 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++..+..+++.++++.+ | +++.+.|+..+. +...+.+++++ T Consensus 2 ~~~Ig~v~~~~~~------------~~~~~~~~~~~~~~~~~~-------g--~~~~~~~~~~~~----~~~~~~~~~l~ 56 (309) T 1GLG_A 2 DTRIGVTIYKYDD------------NFMSVVRKAIEQDAKAAP-------D--VQLLMNDSQNDQ----SKQNDQIDVLL 56 (309) T ss_dssp CEEEEEEESCTTC------------HHHHHHHHHHHHHHHTCT-------T--EEEEEEECTTCH----HHHHHHHHHHH T ss_pred CcEEEEEEccCCC------------HHHHHHHHHHHHHHHhCC-------C--CeEEEecCCCCH----HHHHHHHHHHH Confidence 5789999987542 255677788888887653 2 234444443332 22233344333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . ++++++|+...+... ......+...++|+|..+...+.... ...++.+++.+++...+ T Consensus 57 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~-~~~~~~~~v~~d~~~~~ 116 (309) T 1GLG_A 57 A-------------------KGVKALAINLVDPAAAGTVIEKARGQNVPVVFFNKEPSRKAL-DSYDKAYYVGTDSKESG 116 (309) T ss_dssp H-------------------TTCSEEEECCSSGGGHHHHHHHHHTTTCCEEEESSCCCHHHH-HTCTTEEEEECCHHHHH T ss_pred H-------------------CCCCEEEEeCCChhHHHHHHHHHhhCCCCEEEEccCCChhhc-ccCCcceEEecCcHHHH Confidence 2 477877764433322 23445566789999987764432110 01245667777776666 Q NP_000836.2 204 QAMVDIVT-A----L-------GWNYVSTLA--SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRL 269 (908) Q Consensus 204 ~~~~~~l~-~----~-------~~~~v~ii~--~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l 269 (908) +.+++++. + . +.++++++. .++.++..+.+++++.+++. ++.+........+....+....++++ T Consensus 117 ~~~~~~~~~~l~~~~g~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~ 195 (309) T 1GLG_A 117 IIQGDLIAKHWAANQGWDLNKDGQIQFVLLKGEPGHPDAEARTTYVIKELNDK-GIKTEQLQLDTAMWDTAQAKDKMDAW 195 (309) T ss_dssp HHHHHHHHHHHHHCGGGCTTCSSSEEEEEEECSTTCHHHHHHHHHHHHHHHHT-TCCEEEEEEEECTTCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHccCCccCCCCcEEEEEEEcCCCCccHHHHHHHHHHHHHhc-CCceeEeeccccCCCHHHHHHHHHHH Confidence 66654432 1 1 457788884 33445566777888877764 34432211111001112333445555 Q NP_000836.2 270 LET---PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSD 309 (908) Q Consensus 270 ~~~---~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~ 309 (908) ++. .++++|++.. +..+..+++++++.|.. ++.+++.+ T Consensus 196 ~~~~~~~~~~~i~~~~-~~~a~~~~~~l~~~g~~-~~~v~~~~ 236 (309) T 1GLG_A 196 LSGPNANKIEVVIANN-DAMAMGAVEALKAHNKS-SIPVFGVD 236 (309) T ss_dssp TTSTTTTTCCEEEESS-HHHHHHHHHHHHHTTCT-TSCEECSB T ss_pred HcCCCCCCCCEEEECC-HHHHHHHHHHHHHCCCC-CCCEEEec Confidence 421 3567777664 44556678888877762 33444443 No 242 >2FVY_A D-galactose-binding periplasmic protein; PERIPLASMIC BINDING PROTIEN, HINGE, CHEMOTAXIS; HET: BGC; 0.92A {Escherichia coli} SCOP: c.93.1.1 Probab=96.97 E-value=1.6e-06 Score=87.65 Aligned_cols=217 Identities=13% Similarity=0.037 Sum_probs=117.0 Template_Neff=11.900 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++..+..+++.++++.+ | +++.+.|+..+. +...+.+++++ T Consensus 2 ~~~Ig~v~~~~~~------------~~~~~~~~~~~~~~~~~~-------g--~~~~~~~~~~~~----~~~~~~~~~l~ 56 (309) T 2FVY_A 2 DTRIGVTIYKYDD------------NFMSVVRKAIEQDAKAAP-------D--VQLLMNDSQNDQ----SKQNDQIDVLL 56 (309) T ss_dssp CEEEEEEESCTTS------------HHHHHHHHHHHHHHHTCT-------T--EEEEEEECTTCH----HHHHHHHHHHH T ss_pred CcEEEEEEccCCC------------HHHHHHHHHHHHHHHhCC-------C--CeEEEecCCCCH----HHHHHHHHHHH Confidence 5789999987542 255677788888887653 2 234444443332 22233344333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . ++++++|+...+... ......+...++|+|..+...+.... ...++.+++.+++...+ T Consensus 57 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~-~~~~~~~~v~~d~~~~~ 116 (309) T 2FVY_A 57 A-------------------KGVKALAINLVDPAAAGTVIEKARGQNVPVVFFNKEPSRKAL-DSYDKAYYVGTDSKESG 116 (309) T ss_dssp H-------------------TTCSEEEECCSSGGGHHHHHHHHHTTTCCEEEESSCCCHHHH-HTCTTEEEEECCHHHHH T ss_pred H-------------------CCCCEEEEeCCChhHHHHHHHHHhhCCCCEEEEccCCChhhc-ccCCcceEEecCcHHHH Confidence 2 477877764433322 23445566789999987764432110 01245667777776666 Q NP_000836.2 204 QAMVDIVT-A----L-------GWNYVSTLA--SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRL 269 (908) Q Consensus 204 ~~~~~~l~-~----~-------~~~~v~ii~--~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l 269 (908) +.+++++. + . +.++++++. .++.++..+.+++++.+++. ++.+........+....+....++++ T Consensus 117 ~~~~~~~~~~l~~~~g~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~ 195 (309) T 2FVY_A 117 IIQGDLIAKHWAANQGWDLNKDGQIQFVLLKGEPGHPDAEARTTYVIKELNDK-GIKTEQLQLDTAMWDTAQAKDKMDAW 195 (309) T ss_dssp HHHHHHHHHHHHHCGGGCTTCSSSEEEEEEECSTTCHHHHHHHHHHHHHHHHT-TCCEEEEEEEECTTCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHccCCccCCCCcEEEEEEEcCCCCccHHHHHHHHHHHHHhc-CCceeEeeccccCCCHHHHHHHHHHH Confidence 66654432 1 1 457788884 33445566777888877764 34432211111001112333445555 Q NP_000836.2 270 LET---PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSD 309 (908) Q Consensus 270 ~~~---~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~ 309 (908) ++. .++++|++.. +..+..+++++++.|.. ++.+++.+ T Consensus 196 ~~~~~~~~~~~i~~~~-~~~a~~~~~~l~~~g~~-~~~v~~~~ 236 (309) T 2FVY_A 196 LSGPNANKIEVVIANN-DAMAMGAVEALKAHNKS-SIPVFGVD 236 (309) T ss_dssp HTSTTGGGCCEEEESS-HHHHHHHHHHHHHTTCT-TSCEECSB T ss_pred HcCCCCCCCCEEEECC-HHHHHHHHHHHHHCCCC-CCCEEEec Confidence 421 3567777664 44556678888877762 33444443 No 243 >3M9W_A D-xylose-binding periplasmic protein; xylose binding protein, xylose, conformational; 2.15A {Escherichia coli} Probab=96.97 E-value=1.6e-06 Score=87.92 Aligned_cols=211 Identities=9% Similarity=0.051 Sum_probs=115.4 Template_Neff=11.500 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||+++|.... .++.....+++.++++.+ +++.+.|...++. ...+.+++++ T Consensus 2 ~~~Igvv~~~~~~------------~~~~~~~~g~~~a~~~~g----------~~l~~~~~~~~~~----~~~~~~~~l~ 55 (313) T 3M9W_A 2 EVKIGMAIDDLRL------------ERWQKDRDIFVKKAESLG----------AKVFVQSANGNEE----TQMSQIENMI 55 (313) T ss_dssp -CEEEEEESCCSS------------STTHHHHHHHHHHHHHTS----------CEEEEEECTTCHH----HHHHHHHHHH T ss_pred CcEEEEEeCCCcc------------hHHHhhHHHHHHHHHHcC----------CEEEEEeCCCCHH----HHHHHHHHHH Confidence 5789999985422 245567778888777642 3444555443322 2233344433 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++|....... .......+...++|+|..+...+. .++.+++..++...+ T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~~~~ 110 (313) T 3M9W_A 56 N-------------------RGVDVLVIIPYNGQVLSNVVKEAKQEGIKVLAYDRMIND------ADIDFYISFDNEKVG 110 (313) T ss_dssp H-------------------TTCSEEEEECSSTTSCHHHHHHHHTTTCEEEEESSCCTT------SCCSEEEEECHHHHH T ss_pred H-------------------CCCCEEEEecCCcchHHHHHHHHHHCCCEEEEECCCCCC------CCccEEEECCHHHHH Confidence 2 46777765433322 224445566789999987654321 234466777777777 Q NP_000836.2 204 QAMVDIVTALG-WNYVSTLAS--EGNYGESGVEAFTQISREIG---GVCIAQSQKIPREPRPGEFEKIIKRLLET--PNA 275 (908) Q Consensus 204 ~~~~~~l~~~~-~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~---~i~v~~~~~~~~~~~~~~~~~~~~~l~~~--~~~ 275 (908) ..+++++.+.+ .++++++.. +..++..+.+++++.+++.+ .+.+....... ..+..+....++++++. .++ T Consensus 111 ~~~~~~l~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~ 189 (313) T 3M9W_A 111 ELQAKALVDIVPQGNYFLMGGSPVDNNAKLFRAGQMKVLKPYVDSGKIKVVGDQWVD-GWLPENALKIMENALTANNNKI 189 (313) T ss_dssp HHHHHHHHHHCSSEEEEEEESCTTCHHHHHHHHHHHHHHHHHHHTTSEEEEEEEECG-GGCHHHHHHHHHHHHHHTTTCC T ss_pred HHHHHHHHHhCCCCCEEEEeCCCCChhHHHHHHHHHHHHHHhHHcCCeEEEccccCC-CCCHHHHHHHHHHHHHHCCCCC Confidence 77888775544 345777764 23455667777877776642 02222111110 01112334445555421 357 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|++.. +..+..+++++++.|+..++.+++. T Consensus 190 d~i~~~~-~~~a~~~~~~~~~~g~~~~i~vig~ 221 (313) T 3M9W_A 190 DAVVASN-DATAGGAIQALSAQGLSGKVAISGQ 221 (313) T ss_dssp CEEEESS-HHHHHHHHHHHHTTTCTTTSEECCC T ss_pred CEEEECC-hHHHHHHHHHHHHCCCCCCcEEecC Confidence 7877664 4456677888887776323334433 No 244 >3MA0_A D-xylose-binding periplasmic protein; xylose binding protein, xylose, conformational; HET: XYP; 2.2A {Escherichia coli} Probab=96.97 E-value=1.6e-06 Score=87.92 Aligned_cols=211 Identities=9% Similarity=0.051 Sum_probs=115.9 Template_Neff=11.500 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||+++|.... .++.....+++.++++.+ +++.+.|...++. ...+.+++++ T Consensus 2 ~~~Igvv~~~~~~------------~~~~~~~~g~~~a~~~~g----------~~l~~~~~~~~~~----~~~~~~~~l~ 55 (313) T 3MA0_A 2 EVKIGMAIDDLRL------------ERWQKDRDIFVKKAESLG----------AKVFVQSANGNEE----TQMSQIENMI 55 (313) T ss_dssp CCEEEEEESCSCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECSSCHH----HHHHHHHHHH T ss_pred CcEEEEEeCCCcc------------hHHHhhHHHHHHHHHHcC----------CEEEEEeCCCCHH----HHHHHHHHHH Confidence 5789999985422 245567778888777642 3444555443322 2233344433 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++|....... .......+...++|+|..+...+. .++.+++..++...+ T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~~~~ 110 (313) T 3MA0_A 56 N-------------------RGVDVLVIIPYNGQVLSNVVKEAKQEGIKVLAYDRMIND------ADIDFYISFDNEKVG 110 (313) T ss_dssp H-------------------TTCSEEEECCSSTTSCHHHHHHHHHTTCEEEEESSCCCS------SCCSEEEEECHHHHH T ss_pred H-------------------CCCCEEEEecCCcchHHHHHHHHHHCCCEEEEECCCCCC------CCccEEEECCHHHHH Confidence 2 46777765433322 224445566789999987654321 234466777777777 Q NP_000836.2 204 QAMVDIVTALG-WNYVSTLAS--EGNYGESGVEAFTQISREIG---GVCIAQSQKIPREPRPGEFEKIIKRLLET--PNA 275 (908) Q Consensus 204 ~~~~~~l~~~~-~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~---~i~v~~~~~~~~~~~~~~~~~~~~~l~~~--~~~ 275 (908) ..+++++.+.+ .++++++.. +..++..+.+++++.+++.+ .+.+....... ..+..+....++++++. .++ T Consensus 111 ~~~~~~l~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~ 189 (313) T 3MA0_A 111 ELQAKALVDIVPQGNYFLMGGSPVDNNAKLFRAGQMKVLKPYVDSGKIKVVGDQWVD-GWLPENALKIMENALTANNNKI 189 (313) T ss_dssp HHHHHHHHHHCSSEEEEEEECCTTCHHHHHHHHHHHHHHHHHHHTTSEEEEEEEECG-GGCHHHHHHHHHHHHHHTTTCC T ss_pred HHHHHHHHHhCCCCCEEEEeCCCCChhHHHHHHHHHHHHHHhHHcCCeEEEccccCC-CCCHHHHHHHHHHHHHHCCCCC Confidence 77888775544 345777764 23455667777877776642 02222111110 01112334445555421 357 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|++.. +..+..+++++++.|+..++.+++. T Consensus 190 d~i~~~~-~~~a~~~~~~~~~~g~~~~i~vig~ 221 (313) T 3MA0_A 190 DAVVASN-DATAGGAIQALSAQGLSGKVAISGQ 221 (313) T ss_dssp CEEEESS-HHHHHHHHHHHHTTTCTTTSEECCC T ss_pred CEEEECC-hHHHHHHHHHHHHCCCCCCcEEecC Confidence 7877664 4456677888887776323334433 No 245 >3MA0_C D-xylose-binding periplasmic protein; xylose binding protein, xylose, conformational; HET: XYP; 2.2A {Escherichia coli} Probab=96.97 E-value=1.6e-06 Score=87.92 Aligned_cols=211 Identities=9% Similarity=0.051 Sum_probs=115.9 Template_Neff=11.500 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||+++|.... .++.....+++.++++.+ +++.+.|...++. ...+.+++++ T Consensus 2 ~~~Igvv~~~~~~------------~~~~~~~~g~~~a~~~~g----------~~l~~~~~~~~~~----~~~~~~~~l~ 55 (313) T 3MA0_C 2 EVKIGMAIDDLRL------------ERWQKDRDIFVKKAESLG----------AKVFVQSANGNEE----TQMSQIENMI 55 (313) T ss_dssp CCEEEEEECCSCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCHH----HHHHHHHHHH T ss_pred CcEEEEEeCCCcc------------hHHHhhHHHHHHHHHHcC----------CEEEEEeCCCCHH----HHHHHHHHHH Confidence 5789999985422 245567778888777642 3444555443322 2233344433 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++|....... .......+...++|+|..+...+. .++.+++..++...+ T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~~~~ 110 (313) T 3MA0_C 56 N-------------------RGVDVLVIIPYNGQVLSNVVKEAKQEGIKVLAYDRMIND------ADIDFYISFDNEKVG 110 (313) T ss_dssp H-------------------HTCSEEEECCSSTTSCHHHHHHHHHTTCEEEEESSCCTT------SCCSEEEEECHHHHH T ss_pred H-------------------CCCCEEEEecCCcchHHHHHHHHHHCCCEEEEECCCCCC------CCccEEEECCHHHHH Confidence 2 46777765433322 224445566789999987654321 234466777777777 Q NP_000836.2 204 QAMVDIVTALG-WNYVSTLAS--EGNYGESGVEAFTQISREIG---GVCIAQSQKIPREPRPGEFEKIIKRLLET--PNA 275 (908) Q Consensus 204 ~~~~~~l~~~~-~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~---~i~v~~~~~~~~~~~~~~~~~~~~~l~~~--~~~ 275 (908) ..+++++.+.+ .++++++.. +..++..+.+++++.+++.+ .+.+....... ..+..+....++++++. .++ T Consensus 111 ~~~~~~l~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~ 189 (313) T 3MA0_C 111 ELQAKALVDIVPQGNYFLMGGSPVDNNAKLFRAGQMKVLKPYVDSGKIKVVGDQWVD-GWLPENALKIMENALTANNNKI 189 (313) T ss_dssp HHHHHHHHHHCCSEEEEEEECCTTCHHHHHHHHHHHHHHHHHHHTTSEEEEEEEECG-GGCHHHHHHHHHHHHHHTTTCC T ss_pred HHHHHHHHHhCCCCCEEEEeCCCCChhHHHHHHHHHHHHHHhHHcCCeEEEccccCC-CCCHHHHHHHHHHHHHHCCCCC Confidence 77888775544 345777764 23455667777877776642 02222111110 01112334445555421 357 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|++.. +..+..+++++++.|+..++.+++. T Consensus 190 d~i~~~~-~~~a~~~~~~~~~~g~~~~i~vig~ 221 (313) T 3MA0_C 190 DAVVASN-DATAGGAIQALSAQGLSGKVAISGQ 221 (313) T ss_dssp CEEEESS-HHHHHHHHHHHHTTTCTTTSEECCC T ss_pred CEEEECC-hHHHHHHHHHHHHCCCCCCcEEecC Confidence 7877664 4456677888887776323334433 No 246 >5IBQ_A Probable ribose ABC transporter, substrate-binding; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: XXM; 1.2A {Rhizobium etli} Probab=96.97 E-value=1.6e-06 Score=87.77 Aligned_cols=217 Identities=10% Similarity=0.036 Sum_probs=115.8 Template_Neff=11.500 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) .....++..+||+++|..+. .++.....+++.++++.+ +++.+.+...++ +... T Consensus 17 ~~~~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~ 70 (310) T 5IBQ_A 17 NLYFQSMADLIAIITPAHDN------------PFFKAEAVGAEAKAKELG----------YETLVMTHDDDA----NKQS 70 (310) T ss_dssp ------CCCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHH T ss_pred ccceeeCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCH----HHHH Confidence 34556788999999997542 255667778888777642 334444443332 2223 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +.+++++. .+++++|+...... .......+.+.++|+|..+...+. ..++++++. T Consensus 71 ~~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~ 126 (310) T 5IBQ_A 71 EMIDTAIG-------------------RGAKAIILDNAGADASVAAVKKAKDAGIPSFLIDREINA-----TGVAVAQIV 126 (310) T ss_dssp HHHHHHHH-------------------TTCSEEEECCSCTTTTHHHHHHHHHTTCCEEEESSCCSC-----SSSSSEEEE T ss_pred HHHHHHHH-------------------CCCCEEEEeCCCchhhHHHHHHHHHCCCCEEEeCCCCCC-----CCCceEEEE Confidence 33343332 46787776443332 223344566789999987754321 123456677 Q NP_000836.2 197 PPDSYQAQAMVDIVTALGWN--YVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE- 271 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~~~~~--~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~- 271 (908) .+....++.+++++.+.+.+ +++++.. +..++..+.+++++.+++.+...+....... .+..+....++++++ T Consensus 127 ~d~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~ 204 (310) T 5IBQ_A 127 SNNYQGAQLGAQEFVKLMGEKGNYVELVGKESDTNAGIRSQGYHDVIDDYPEMKSVAKQSAN--WSQTEAYSKMETILQA 204 (310) T ss_dssp ECHHHHHHHHHHHHHHHTTTCEEEEEEECCTTSHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHH T ss_pred cChHHHHHHHHHHHHHHhCCcceEEEEEcCCCChhHHHHHHHHHHHHHHCCCeEEEEEeeCC--CCHHHHHHHHHHHHHH Confidence 77777777888887654433 3555553 2344566777888877764212221111111 111223344455542 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ..++++|++.. +..+..+++++++.|.. ++.+++. T Consensus 205 ~~~~~~i~~~~-~~~a~~~~~al~~~g~~-~i~vv~~ 239 (310) T 5IBQ_A 205 NPDIKGVISGN-DTMAMGAIAALQAAGRK-DVIVVGF 239 (310) T ss_dssp CCSCCEEEESS-HHHHHHHHHHHHHTTCT-TSEEECS T ss_pred CCCCCEEEECC-hHHHHHHHHHHHHCCCC-CcEEEEe Confidence 13577776654 44566777788777762 3344443 No 247 >3K9C_B Transcriptional regulator, LacI family protein; PSI-II, 11026W, LacI family protein; HET: GOL; 2.14A {Rhodococcus jostii} Probab=96.96 E-value=1.7e-06 Score=86.50 Aligned_cols=201 Identities=16% Similarity=0.153 Sum_probs=116.7 Template_Neff=11.800 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||++.|.++ .++.....+++.++++.+ +++.+.++..+ . ...+.+ T Consensus 8 ~~~~~~~I~~i~~~~~-------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~-~----~~~~~~ 59 (289) T 3K9C_B 8 RQASSRLLGVVFELQQ-------------PFHGDLVEQIYAAATRRG----------YDVMLSAVAPS-R----AEKVAV 59 (289) T ss_dssp -CCSSEEEEEEEETTC-------------HHHHHHHHHHHHHHHHTT----------EEEEEEEEBTT-B----CHHHHH T ss_pred hhCCCCeEEEEeCCCC-------------hhHHHHHHHHHHHHHHCC----------CeEEEEeCCCC-H----HHHHHH Confidence 3457899999987543 245667788888877653 23334443322 1 122333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++.. .++|++|+...+.....+ ..+ ..++|+|..+...+ .+..+.+..++. T Consensus 60 ~~l~~-------------------~~~d~ii~~~~~~~~~~~-~~~-~~~ipvv~~~~~~~-------~~~~~~v~~d~~ 111 (289) T 3K9C_B 60 QALMR-------------------ERCEAAILLGTRFDTDEL-GAL-ADRVPALVVARASG-------LPGVGAVRGDDV 111 (289) T ss_dssp HHHHT-------------------TTEEEEEEETCCCCHHHH-HHH-HTTSCEEEESSCCC-------STTSEEEEECHH T ss_pred HHHHh-------------------CCCCEEEEECCCCCHHHH-HHH-hcCCCEEEEeccCC-------CCCCcEEEeCcH Confidence 33332 478888876543332222 233 46899888765432 134566777777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAV 278 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~vi 278 (908) ..++.+++++.+.+.++++++... +.++..+.++|++.+++. ++.+....... ..+..+....++++++. .++|+| T Consensus 112 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~d~i 189 (289) T 3K9C_B 112 AGITLAVDHLTELGHRNIAHIDGADAPGGADRRAGFLAAMDRH-GLSASATVVTG-GTTETEGAEGMHTLLEMPTPPTAV 189 (289) T ss_dssp HHHHHHHHHHHHTTCCSEEEEECTTSTTHHHHHHHHHHHHHHT-TCGGGEEEEEC-CSSHHHHHHHHHHHHHSSSCCSEE T ss_pred HHHHHHHHHHHHCCCCcEEEeeCCCCCChHHHHHHHHHHHHHc-CCCCCCcEEeC-CCChHHHHHHHHHHhcCCCCCCEE Confidence 777788888766678899999853 345667778888887764 34433211111 01112233445555421 247887 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 190 ~~~~-~~~a~~~~~~l~~~g~~ 210 (289) T 3K9C_B 190 VAFN-DRCATGVLDLLVRSGRD 210 (289) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHCCCC Confidence 7664 44566778888877764 No 248 >4RY8_B Periplasmic binding protein/LacI transcriptional regulator; SUGAR TRANSPORTER, ENZYME FUNCTION INITIATIVE; HET: SR1; 1.75A {Thermotoga lettingae TMO} Probab=96.95 E-value=1.7e-06 Score=88.41 Aligned_cols=215 Identities=9% Similarity=0.041 Sum_probs=118.1 Template_Neff=11.300 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++.++||++.|..+. .++.....+++.++++.+ +++.+.+...++ +...+. T Consensus 10 ~~~~~~~~Igv~~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~ 63 (329) T 4RY8_B 10 FENPKNVRIALVREVGEG------------SFFERYLAGAQSMARELG----------VTLLEATAHGDM----ARMVTM 63 (329) T ss_dssp GGSGGGCEEEEEESCCCS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCH----HHHHHH T ss_pred cCCCCCcEEEEEEeCCCC------------hHHHHHHHHHHHHHHHhC----------CEEEEEeCCCCH----HHHHHH Confidence 456678999999997542 245667778888877642 334444543332 122333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+.. .......+...++|+|..+...+ .+.++.+.++ T Consensus 64 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d 117 (329) T 4RY8_B 64 IENFIT-------------------QRVDAIIIDHGRPDPLMPKIKEALDRGIRVVTFDLVVD-------DNRVPEIEQD 117 (329) T ss_dssp HHHHHH-------------------TTCSEEEEESCCHHHHHHHHHHHHHHTCEEEEESCCCS-------CTTSCEEECC T ss_pred HHHHHh-------------------cCCCEEEECCCCccccHHHHHHHHHCCCEEEEECCCCC-------CCCCcEEecC Confidence 443332 47887776443332 22344556778999998776432 2345667777 Q NP_000836.2 199 DSYQAQAMVDIVTA--LGWNYVSTLASEGNYGESGVEAFTQISREI-GGVCIAQSQK-IPREPRPGEFEKIIKRLLE-TP 273 (908) Q Consensus 199 ~~~~~~~~~~~l~~--~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-~~i~v~~~~~-~~~~~~~~~~~~~~~~l~~-~~ 273 (908) ....++.+++++.+ .+.++++++..+..++......+.+.+.+. .++.+..... ... .+..+....++++++ .. T Consensus 118 ~~~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~l~~~~ 196 (329) T 4RY8_B 118 DLLIGYLISKQLAVDFAGNANVIYVNVGGFAPLDKRDKMWQIIKWRFPGIKEVAKIGAVTG-STAADTQTRMEAAMKEKP 196 (329) T ss_dssp HHHHHHHHHHHHHHHTTTCEEEEEECCSSSHHHHHHHHHHHHHHHHCTTEEEEEEECCCCS-SHHHHHHHHHHHHHHHCT T ss_pred hHHHHHHHHHHHHHHcCCCceEEEEEcCCCccHHHHHHHHHHHHHHCCCcEEEEEEcCCCC-CCHHHHHHHHHHHHHHCC Confidence 77777788877755 577899998754434433444444444331 1233321110 110 111233344555542 12 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++++|++.. +..+..+++++++.|+..++.+++. T Consensus 197 ~~~~I~~~~-~~~a~~~~~al~~~g~~~~v~v~~~ 230 (329) T 4RY8_B 197 EANAVLAMW-DEFAKGAVRAIMQAGKSDQFKVYSV 230 (329) T ss_dssp TCCEEEESS-HHHHHHHHHHHHHHTCGGGCEEEEE T ss_pred CCCEEEEcC-hHHHHHHHHHHHHcCCCCceEEEEe Confidence 467776553 4456678888887776423334443 No 249 >4RY8_C Periplasmic binding protein/LacI transcriptional regulator; SUGAR TRANSPORTER, ENZYME FUNCTION INITIATIVE; HET: SR1; 1.75A {Thermotoga lettingae TMO} Probab=96.95 E-value=1.7e-06 Score=88.41 Aligned_cols=215 Identities=9% Similarity=0.041 Sum_probs=117.0 Template_Neff=11.300 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++.++||++.|..+. .++.....+++.++++.+ +++.+.+...++ +...+. T Consensus 10 ~~~~~~~~Igv~~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~ 63 (329) T 4RY8_C 10 FENPKNVRIALVREVGEG------------SFFERYLAGAQSMARELG----------VTLLEATAHGDM----ARMVTM 63 (329) T ss_dssp C--CTTCEEEEEESCCCS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCH----HHHHHH T ss_pred cCCCCCcEEEEEEeCCCC------------hHHHHHHHHHHHHHHHhC----------CEEEEEeCCCCH----HHHHHH Confidence 456678999999997542 245667778888877642 334444543332 122333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+.. .......+...++|+|..+...+ .+.++.+.++ T Consensus 64 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d 117 (329) T 4RY8_C 64 IENFIT-------------------QRVDAIIIDHGRPDPLMPKIKEALDRGIRVVTFDLVVD-------DNRVPEIEQD 117 (329) T ss_dssp HHHHHH-------------------TTCSEEEEESCCHHHHHHHHHHHHHTTCEEEEESCCCS-------CTTSCEEECC T ss_pred HHHHHh-------------------cCCCEEEECCCCccccHHHHHHHHHCCCEEEEECCCCC-------CCCCcEEecC Confidence 443332 47887776443332 22344556778999998776432 2345667777 Q NP_000836.2 199 DSYQAQAMVDIVTA--LGWNYVSTLASEGNYGESGVEAFTQISREI-GGVCIAQSQK-IPREPRPGEFEKIIKRLLE-TP 273 (908) Q Consensus 199 ~~~~~~~~~~~l~~--~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-~~i~v~~~~~-~~~~~~~~~~~~~~~~l~~-~~ 273 (908) ....++.+++++.+ .+.++++++..+..++......+.+.+.+. .++.+..... ... .+..+....++++++ .. T Consensus 118 ~~~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~l~~~~ 196 (329) T 4RY8_C 118 DLLIGYLISKQLAVDFAGNANVIYVNVGGFAPLDKRDKMWQIIKWRFPGIKEVAKIGAVTG-STAADTQTRMEAAMKEKP 196 (329) T ss_dssp HHHHHHHHHHHHHHHTTTCEEEEEECCSSCHHHHHHHHHHHHHHHHCTTEEEEEEECCCCS-SHHHHHHHHHHHHHHHCT T ss_pred hHHHHHHHHHHHHHHcCCCceEEEEEcCCCccHHHHHHHHHHHHHHCCCcEEEEEEcCCCC-CCHHHHHHHHHHHHHHCC Confidence 77777788877755 577899998754434433444444444331 1233321110 110 111233344555542 12 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++++|++.. +..+..+++++++.|+..++.+++. T Consensus 197 ~~~~I~~~~-~~~a~~~~~al~~~g~~~~v~v~~~ 230 (329) T 4RY8_C 197 EANAVLAMW-DEFAKGAVRAIMQAGKSDQFKVYSV 230 (329) T ss_dssp TCCEEEESS-HHHHHHHHHHHHHHTCGGGCEEEEE T ss_pred CCCEEEEcC-hHHHHHHHHHHHHcCCCCceEEEEe Confidence 467776553 4456678888887776423334443 No 250 >3ROT_A ABC sugar transporter, periplasmic sugar; NYSGRC, PSI-BIOLOGY, Structural Genomics, New; HET: GOL; 1.91A {Legionella pneumophila subsp. pneumophila} Probab=96.93 E-value=1.9e-06 Score=86.61 Aligned_cols=205 Identities=8% Similarity=0.085 Sum_probs=118.1 Template_Neff=11.400 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) .+++||++.|.... .++.....+++.++++. |+++.+...|+..++ +...+.++++ T Consensus 2 ~~~~I~vi~~~~~~------------~~~~~~~~g~~~a~~~~--------g~~v~~~~~~~~~~~----~~~~~~~~~l 57 (297) T 3ROT_A 2 VRDKYYLITHGSQD------------PYWTSLFQGAKKAAEEL--------KVDLQILAPPGANDV----PKQVQFIESA 57 (297) T ss_dssp -CCEEEEECSCCCS------------HHHHHHHHHHHHHHHHH--------TCEEEEECCSSSCCH----HHHHHHHHHH T ss_pred CCcEEEEEccCCCC------------HHHHHHHHHHHHHHHHh--------CCEEEEECCCCCCCH----HHHHHHHHHH Confidence 46789999985332 24566778888888775 345655555433332 2233344443 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAA-ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) +. .+++++|+.. .+.........+...++|+|..+...+... ..++++++.+++... T Consensus 58 ~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~---~~~~~~~v~~d~~~~ 115 (297) T 3ROT_A 58 LA-------------------TYPSGIATTIPSDTAFSKSLQRANKLNIPVIAVDTRPKDKT---KNPYLVFLGSDNLLA 115 (297) T ss_dssp HH-------------------TCCSEEEECCCCSSTTHHHHHHHHHHTCCEEEESCCCSCTT---TSCCSCEEECCHHHH T ss_pred HH-------------------hCCCEEEEeCCChHHHHHHHHHHHHCCCCEEEEcCCCCCCC---CCCceeEEeCChHHH Confidence 32 4788777643 222222445556678999998776543211 124567777777777 Q NP_000836.2 203 AQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 203 ~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ++.+++++.+. +.++++++.. ++.++..+.+++++.+++. ++.+... ... .+..+....+++++.. .++++ T Consensus 116 ~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-g~~~~~~-~~~--~~~~~~~~~~~~~~~~~~~~~~ 191 (297) T 3ROT_A 116 GKKLGEKALELTPSAKRALVLNPQPGHIGLEKRAYGIKTILQDK-GIFFEEL-DVG--TDPNQVQSRVKSYFKIHPETNI 191 (297) T ss_dssp HHHHHHHHHHHCTTCCEEEEEESCTTCHHHHHHHHHHHHHHHHT-TCEEEEE-ECC--SCHHHHHHHHHHHHHHCTTCCE T ss_pred HHHHHHHHHHhCCCCCeEEEEcCCCCchhHHHHHHHHHHHHHhc-CCeEEEE-eCC--CCHHHHHHHHHHHHHHCCCccE Confidence 88888887665 6789999975 3345667778888888765 3444321 111 1122333445555421 23566 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~ 299 (908) |++.. +..+..+++++++.|. T Consensus 192 i~~~~-~~~a~~~~~~~~~~g~ 212 (297) T 3ROT_A 192 IFCLT-SQALDPLGQMLLHPDR 212 (297) T ss_dssp EEESS-HHHHHHHHHHHHSHHH T ss_pred EEECC-hhhhHHHHHHhhCCCC Confidence 65553 3445566666666553 No 251 >3ROT_B ABC sugar transporter, periplasmic sugar; NYSGRC, PSI-BIOLOGY, Structural Genomics, New; HET: MSE, GOL; 1.91A {Legionella pneumophila subsp. pneumophila} Probab=96.93 E-value=1.9e-06 Score=86.61 Aligned_cols=205 Identities=8% Similarity=0.085 Sum_probs=118.1 Template_Neff=11.400 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) .+++||++.|.... .++.....+++.++++. |+++.+...|+..++ +...+.++++ T Consensus 2 ~~~~I~vi~~~~~~------------~~~~~~~~g~~~a~~~~--------g~~v~~~~~~~~~~~----~~~~~~~~~l 57 (297) T 3ROT_B 2 VRDKYYLITHGSQD------------PYWTSLFQGAKKAAEEL--------KVDLQILAPPGANDV----PKQVQFIESA 57 (297) T ss_dssp -CCEEEEECSCCSS------------HHHHHHHHHHHHHHHHH--------TCEEEEECCSSSCCH----HHHHHHHHHH T ss_pred CCcEEEEEccCCCC------------HHHHHHHHHHHHHHHHh--------CCEEEEECCCCCCCH----HHHHHHHHHH Confidence 46789999985332 24566778888888775 345655555433332 2233344443 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAA-ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) +. .+++++|+.. .+.........+...++|+|..+...+... ..++++++.+++... T Consensus 58 ~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~---~~~~~~~v~~d~~~~ 115 (297) T 3ROT_B 58 LA-------------------TYPSGIATTIPSDTAFSKSLQRANKLNIPVIAVDTRPKDKT---KNPYLVFLGSDNLLA 115 (297) T ss_dssp HT-------------------TCCSEEEECCCCSSSSHHHHHHHHHTTCCEEEESCCCSCTT---TSCCSCEEECCHHHH T ss_pred HH-------------------hCCCEEEEeCCChHHHHHHHHHHHHCCCCEEEEcCCCCCCC---CCCceeEEeCChHHH Confidence 32 4788777643 222222445556678999998776543211 124567777777777 Q NP_000836.2 203 AQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 203 ~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ++.+++++.+. +.++++++.. ++.++..+.+++++.+++. ++.+... ... .+..+....+++++.. .++++ T Consensus 116 ~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-g~~~~~~-~~~--~~~~~~~~~~~~~~~~~~~~~~ 191 (297) T 3ROT_B 116 GKKLGEKALELTPSAKRALVLNPQPGHIGLEKRAYGIKTILQDK-GIFFEEL-DVG--TDPNQVQSRVKSYFKIHPETNI 191 (297) T ss_dssp HHHHHHHHHHHCTTCCEEEEEESSTTCHHHHHHHHHHHHHHHHT-TCEEEEE-ECC--SCHHHHHHHHHHHHHHCTTCCE T ss_pred HHHHHHHHHHhCCCCCeEEEEcCCCCchhHHHHHHHHHHHHHhc-CCeEEEE-eCC--CCHHHHHHHHHHHHHHCCCccE Confidence 88888887665 6789999975 3345667778888888765 3444321 111 1122333445555421 23566 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~ 299 (908) |++.. +..+..+++++++.|. T Consensus 192 i~~~~-~~~a~~~~~~~~~~g~ 212 (297) T 3ROT_B 192 IFCLT-SQALDPLGQMLLHPDR 212 (297) T ss_dssp EEESS-HHHHHHHHHHHHSHHH T ss_pred EEECC-hhhhHHHHHHhhCCCC Confidence 65553 3445566666666553 No 252 >5BRA_A Putative periplasmic binding protein with; Periplasmic solute binding Protein, ENZYME; HET: MSE; 2.971A {Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)} Probab=96.93 E-value=1.9e-06 Score=89.01 Aligned_cols=220 Identities=8% Similarity=-0.032 Sum_probs=122.4 Template_Neff=10.800 Q NP_000836.2 37 AHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQS 116 (908) Q Consensus 37 ~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~ 116 (908) .......+.++||++.|..+. .++.....+++.++++.+ +++.+...+. .++ +.. T Consensus 36 ~~~~~~~~~~~Igvv~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~v~~~~~~~-~~~----~~~ 90 (350) T 5BRA_A 36 LITTANDKKYTIATVVKVDGI------------AWFDRMRDGVDQFKADTG--------NDVWMVGPSQ-ADA----AAQ 90 (350) T ss_pred HHHhhcCCCeEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC--------CEEEEEeCCC-CCH----HHH Confidence 344556788999999997542 255677888888887763 3444432222 222 223 Q NP_000836.2 117 LTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRV 195 (908) Q Consensus 117 ~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~ 195 (908) .+.+++++. .+++++|+...+.. .......+.+.++|+|..+...+. ...++++ T Consensus 91 ~~~~~~l~~-------------------~~~d~iI~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v 145 (350) T 5BRA_A 91 VQIVENLIA-------------------QGVDAIAIVPFSVEAVEPVLKKARERGIVVISHEASNIQ------NVDYDIE 145 (350) T ss_pred HHHHHHHHH-------------------CCCCEEEECCCChHHHHHHHHHHHHCCCCEEEeCCCCCC------CCCeEEE Confidence 334444332 47888776543322 224455667789999877654321 1334556 Q NP_000836.2 196 VPPDSYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLL 270 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~ 270 (908) .+++...+..+++++.+. +.++++++.. ++.++..+.+++++.+++.+ ++.+.... .....+..+....+++++ T Consensus 146 ~~d~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~l 224 (350) T 5BRA_A 146 AFDNKAYGANLMKELGKSMGGKGKYVTTVGSLTSKSQMEWIDGAVEYQKANFPEMSEATGR-LETYDDANTDYNKLKEAM 224 (350) T ss_pred CCCHHHHHHHHHHHHHHHhCCCcEEEEEeCCCCCHHHHHHHHHHHHHHHHHCCCeEEEEee-cCCCCCHHHHHHHHHHHH Confidence 667666677777777543 5788999885 34456667778887776531 13322110 000011123334455554 Q NP_000836.2 271 ET-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 271 ~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +. .++++|++.. +..+..+++++++.|+..++.+++. T Consensus 225 ~~~~~~~~i~~~~-~~~a~~~~~al~~~g~~~~v~v~g~ 262 (350) T 5BRA_A 225 TAYPDITGILGAP-MPTSAGAGRLIAEGGLKGKVFFAGT 262 (350) T ss_pred HHCCCCCEEEEcC-hhHHHHHHHHHHHCCCCCCeEEEEe Confidence 21 2456665543 4456678888888776423344443 No 253 >2H3H_A Sugar ABC transporter, periplasmic sugar-binding; glucose binding protein, periplasmic binding; HET: BGC; 1.7A {Thermotoga maritima} Probab=96.93 E-value=1.9e-06 Score=87.35 Aligned_cols=209 Identities=10% Similarity=0.057 Sum_probs=113.2 Template_Neff=11.300 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|.+. .++.....+++.++++.+ +++.+...+ ..++ +...+.+++++ T Consensus 1 ~~~Ig~i~~~~~-------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~-~~~~----~~~~~~~~~l~ 54 (313) T 2H3H_A 1 MLTIGVIGKSVH-------------PYWSQVEQGVKAAGKALG--------VDTKFFVPQ-KEDI----NAQLQMLESFI 54 (313) T ss_dssp CCEEEEECSCSS-------------HHHHHHHHHHHHHHHHHT--------CEEEEECCS-SSCH----HHHHHHHHHHH T ss_pred CeEEEEEcCCCC-------------hHHHHHHHHHHHHHHHhC--------CEEEEECCC-ccCH----HHHHHHHHHHH Confidence 367899998642 245667788888887753 333332211 1221 12233344333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++|+...+... ......+...++|+|..+...+. .++++++.+++...+ T Consensus 55 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~~~~ 109 (313) T 2H3H_A 55 A-------------------EGVNGIAIAPSDPTAVIPTIKKALEMGIPVVTLDTDSPD------SGRYVYIGTDNYQAG 109 (313) T ss_dssp H-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCTT------SCCSCEEECCHHHHH T ss_pred H-------------------cCCCEEEECCCChHhhHHHHHHHHHCCCCEEEECCCCCC------CCcceEEeCChHHHH Confidence 2 477877764433322 23445567789999887654321 234566777777777 Q NP_000836.2 204 QAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 204 ~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) +.+++++.+. +.++++++.. ++.++..+.++|.+.+++. ++.+....... .+..+....++++++ ..++++| T Consensus 110 ~~~~~~l~~~~~g~~~i~~~~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~ai 186 (313) T 2H3H_A 110 YTAGLIMKELLGGKGKVVIGTGSLTAMNSLQRIQGFKDAIKDS-EIEIVDILNDE--EDGARAVSLAEAALNAHPDLDAF 186 (313) T ss_dssp HHHHHHHHHHHTSCSEEEEEESCSSCHHHHHHHHHHHHHHTTS-SCEEEEEEECS--SCHHHHHHHHHHHHHHCTTCCEE T ss_pred HHHHHHHHHHhCCCeEEEEEeCCCCchHHHHHHHHHHHHHhcC-CcEEEEEEcCC--CCHHHHHHHHHHHHHHCCCCCEE Confidence 7888877654 6788988875 3345667788888887764 34433211111 111122333445442 1257777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++... .....++.++++.+...++.+++. T Consensus 187 ~~~~~-~~~~~~~~~~~~~~~~~~v~iig~ 215 (313) T 2H3H_A 187 FGVYA-YNGPAQALVVKNAGKVGKVKIVCF 215 (313) T ss_dssp EECST-THHHHHHHHHHHTTCTTTSEEEEE T ss_pred EEcCC-CChHHHHHHHHHCCCCCCeEEEEe Confidence 66542 233444555555554323334433 No 254 >2H3H_B Sugar ABC transporter, periplasmic sugar-binding; glucose binding protein, periplasmic binding; HET: BGC; 1.7A {Thermotoga maritima} Probab=96.93 E-value=1.9e-06 Score=87.35 Aligned_cols=209 Identities=10% Similarity=0.057 Sum_probs=113.2 Template_Neff=11.300 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|.+. .++.....+++.++++.+ +++.+...+ ..++ +...+.+++++ T Consensus 1 ~~~Ig~i~~~~~-------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~-~~~~----~~~~~~~~~l~ 54 (313) T 2H3H_B 1 MLTIGVIGKSVH-------------PYWSQVEQGVKAAGKALG--------VDTKFFVPQ-KEDI----NAQLQMLESFI 54 (313) T ss_dssp CCEEEEECSCSS-------------HHHHHHHHHHHHHHHHHT--------CEEEEECCS-SCCH----HHHHHHHHHHH T ss_pred CeEEEEEcCCCC-------------hHHHHHHHHHHHHHHHhC--------CEEEEECCC-ccCH----HHHHHHHHHHH Confidence 367899998642 245667788888887753 333332211 1221 12233344333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++|+...+... ......+...++|+|..+...+. .++++++.+++...+ T Consensus 55 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~~~~ 109 (313) T 2H3H_B 55 A-------------------EGVNGIAIAPSDPTAVIPTIKKALEMGIPVVTLDTDSPD------SGRYVYIGTDNYQAG 109 (313) T ss_dssp H-------------------HTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCTT------SCCSCEEECCHHHHH T ss_pred H-------------------cCCCEEEECCCChHhhHHHHHHHHHCCCCEEEECCCCCC------CCcceEEeCChHHHH Confidence 2 477877764433322 23445567789999887654321 234566777777777 Q NP_000836.2 204 QAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 204 ~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) +.+++++.+. +.++++++.. ++.++..+.++|.+.+++. ++.+....... .+..+....++++++ ..++++| T Consensus 110 ~~~~~~l~~~~~g~~~i~~~~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~ai 186 (313) T 2H3H_B 110 YTAGLIMKELLGGKGKVVIGTGSLTAMNSLQRIQGFKDAIKDS-EIEIVDILNDE--EDGARAVSLAEAALNAHPDLDAF 186 (313) T ss_dssp HHHHHHHHHHTTTEEEEEEEESCSSSHHHHHHHHHHHHHTTTS-EEEEEEEEECS--SCHHHHHHHHHHHHHHCTTCCEE T ss_pred HHHHHHHHHHhCCCeEEEEEeCCCCchHHHHHHHHHHHHHhcC-CcEEEEEEcCC--CCHHHHHHHHHHHHHHCCCCCEE Confidence 7888877654 6788988875 3345667788888887764 34433211111 111122333445442 1257777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++... .....++.++++.+...++.+++. T Consensus 187 ~~~~~-~~~~~~~~~~~~~~~~~~v~iig~ 215 (313) T 2H3H_B 187 FGVYA-YNGPAQALVVKNAGKVGKVKIVCF 215 (313) T ss_dssp EECST-THHHHHHHHHHHTTCBTTBEEEEE T ss_pred EEcCC-CChHHHHHHHHHCCCCCCeEEEEe Confidence 66542 233444555555554323334433 No 255 >3GBV_A Putative LacI-family transcriptional regulator; NYSGXRC, PSI-II, 11231j, transcriptional regulator; HET: EDO; 2.2A {Bacteroides fragilis} Probab=96.93 E-value=1.9e-06 Score=86.77 Aligned_cols=155 Identities=18% Similarity=0.140 Sum_probs=94.8 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|.+... .++.....+++.++++.|.. +.++++...|.. ++ ....+.++ T Consensus 5 ~~~~~~Ig~i~~~~~~~-----------~~~~~~~~g~~~~~~~~~~~-----~~~i~~~~~~~~-~~----~~~~~~~~ 63 (304) T 3GBV_A 5 SNKKYTFACLLPKHLEG-----------EYWTDVQKGIREAVTTYSDF-----NISANITHYDPY-DY----NSFVATSQ 63 (304) T ss_dssp --CCEEEEEEEECCCTT-----------SHHHHHHHHHHHHHHHTGGG-----CEEEEEEEECSS-CH----HHHHHHHH T ss_pred cCCCeEEEEEccccCCC-----------hhHHHHHHHHHHHHHhhhhc-----CeEEEEecCCCC-CH----HHHHHHHH Confidence 45789999999864321 25567888999998887632 234444444432 22 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. +++|++|....+.. .......+...++|+|..+...+. .++++.+.++.. T Consensus 64 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 118 (304) T 3GBV_A 64 AVIE-------------------EQPDGVMFAPTVPQYTKGFTDALNELGIPYIYIDSQIKD------APPLAFFGQNSH 118 (304) T ss_dssp HHHT-------------------TCCSEEEECCSSGGGTHHHHHHHHHHTCCEEEESSCCTT------SCCSEEEECCHH T ss_pred HHHH-------------------hCCCEEEECCCChhhhHHHHHHHHHcCCCEEEEcCCCCC------CCCcEEEcCChH Confidence 4332 46787765433322 223345566789999987764431 235667777777 Q NP_000836.2 201 YQAQAMVDIVTAL--GWNYVSTLAS------EGNYGESGVEAFTQISREI 242 (908) Q Consensus 201 ~~~~~~~~~l~~~--~~~~v~ii~~------~~~~~~~~~~~~~~~~~~~ 242 (908) ..++.+++++.+. +.++++++.. +..++..+.+++++.+++. T Consensus 119 ~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~ 168 (304) T 3GBV_A 119 QSGYFAARMLMLLAVNDREIVIFRKIHEGVIGSNQQESREIGFRQYMQEH 168 (304) T ss_dssp HHHHHHHHHHHHHSTTCSEEEEEEEEBTTBCCCHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHccCCCeEEEEEeccCCCCCChHHHHHHHHHHHHHHHH Confidence 7788888887654 7789999873 2345566778888877664 No 256 >3HUU_A Transcription regulator like protein; PSI-II, NYSGXRC, 11235m, transcription regulator; 1.95A {Staphylococcus haemolyticus} Probab=96.89 E-value=2.3e-06 Score=86.17 Aligned_cols=205 Identities=13% Similarity=0.116 Sum_probs=115.7 Template_Neff=11.800 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++..+||++.|.++.... ...++.....+++.++++.+ + ++.+.+...++ +...+.+ T Consensus 18 ~~~~~~~Ig~i~~~~~~~~~-------~~~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~ 76 (305) T 3HUU_A 18 ITNKTLTIGLIQKSSAPEIR-------QNPFNSDVLNGINQACNVRG--------Y--STRMTVSENSG----DLYHEVK 76 (305) T ss_dssp ---CCCEEEEECSCCSHHHH-------TSHHHHHHHHHHHHHHHHHT--------C--EEEECCCSSHH----HHHHHHH T ss_pred HcCCCcEEEEEEcCCChhHh-------cCccHHHHHHHHHHHHHHhC--------C--eEEEEEcCCCc----chHHHHH Confidence 34678999999987642100 01345667788888777642 3 33334433321 1222233 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +.+.. +++|++|+...+.. ......+...++|+|..+...+ .+.++++.++.. T Consensus 77 ~~~~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~ 129 (305) T 3HUU_A 77 TMIQS-------------------KSVDGFILLYSLKD-DPIEHLLNEFKVPYLIVGKSLN-------YENIIHIDNDNI 129 (305) T ss_dssp HHHHT-------------------TCCSEEEESSCBTT-CHHHHHHHHTTCCEEEESCCCS-------STTCCEEECCHH T ss_pred HHHHh-------------------CCCCEEEEeccCCC-ChHHHHHHHcCCCEEEECCCCC-------CCCCcEEecChH Confidence 32221 47888886554433 2445566778999998765432 134566777777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL--ETPNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~--~~~~~~ 276 (908) ..++.+++++.+.+.++++++..... ....+.++|++.+++. ++.+.... .. +..+....+++++ ...++| T Consensus 130 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~-~~---~~~~~~~~~~~~~~~~~~~~d 204 (305) T 3HUU_A 130 DAAYQLTQYLYHLGHRHILFLQESGHYAVTEDRSVGFKQYCDDV-KISNDCVV-IK---SMNDLRDFIKQYCIDASHMPS 204 (305) T ss_dssp HHHHHHHHHHHHTTCCSEEEEEESSCBHHHHHHHHHHHHHHHHT-TCCCCEEE-EC---SHHHHHHHC--------CCCS T ss_pred HHHHHHHHHHHHcCCCeEEEEeCCCCchhHHHHHHHHHHHHHHc-CCCcceEE-Ec---chhhHHHHHHHHHHHcCCCCc Confidence 77888888887678889999985432 3466778888887764 34332111 11 1123334444442 123678 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~ 299 (908) +|++.. +..+..+++++++.|+ T Consensus 205 ~i~~~~-~~~a~~~~~~l~~~g~ 226 (305) T 3HUU_A 205 VIITSD-VMLNMQLLNVLYEYQL 226 (305) T ss_dssp EEEESS-HHHHHHHHHHHHHTTC T ss_pred EEEECC-HHHHHHHHHHHHHcCC Confidence 775553 4456778888887776 No 257 >3HUU_C Transcription regulator like protein; PSI-II, NYSGXRC, 11235m, transcription regulator; 1.95A {Staphylococcus haemolyticus} Probab=96.89 E-value=2.3e-06 Score=86.17 Aligned_cols=205 Identities=13% Similarity=0.116 Sum_probs=116.7 Template_Neff=11.800 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++..+||++.|.++.... ...++.....+++.++++.+ + ++.+.+...++ +...+.+ T Consensus 18 ~~~~~~~Ig~i~~~~~~~~~-------~~~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~ 76 (305) T 3HUU_C 18 ITNKTLTIGLIQKSSAPEIR-------QNPFNSDVLNGINQACNVRG--------Y--STRMTVSENSG----DLYHEVK 76 (305) T ss_dssp ---CCCEEEEECSCCCHHHH-------TSHHHHHHHHHHHHHHHHTT--------C--EEEECCCSSHH----HHHHHHH T ss_pred HcCCCcEEEEEEcCCChhHh-------cCccHHHHHHHHHHHHHHhC--------C--eEEEEEcCCCc----chHHHHH Confidence 34678999999987642100 01345667788888777642 3 33334433321 1222233 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +.+.. +++|++|+...+.. ......+...++|+|..+...+ .+.++++.++.. T Consensus 77 ~~~~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~ 129 (305) T 3HUU_C 77 TMIQS-------------------KSVDGFILLYSLKD-DPIEHLLNEFKVPYLIVGKSLN-------YENIIHIDNDNI 129 (305) T ss_dssp HHHHT-------------------TCCSEEEESSCBTT-CHHHHHHHHTTCCEEEESCCCS-------CSSCCEEECCHH T ss_pred HHHHh-------------------CCCCEEEEeccCCC-ChHHHHHHHcCCCEEEECCCCC-------CCCCcEEecChH Confidence 32221 47888886554433 2445566778999998765432 134566777777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL--ETPNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~--~~~~~~ 276 (908) ..++.+++++.+.+.++++++..... ....+.++|++.+++. ++.+.... .. +..+....+++++ ...++| T Consensus 130 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~-~~---~~~~~~~~~~~~~~~~~~~~d 204 (305) T 3HUU_C 130 DAAYQLTQYLYHLGHRHILFLQESGHYAVTEDRSVGFKQYCDDV-KISNDCVV-IK---SMNDLRDFIKQYCIDASHMPS 204 (305) T ss_dssp HHHHHHHHHHHHHTCCCEEEEEESSCBHHHHHHHHHHHHHHHHT-TCCCCEEE-EC---SHHHHHHHHTTC------CCS T ss_pred HHHHHHHHHHHHcCCCeEEEEeCCCCchhHHHHHHHHHHHHHHc-CCCcceEE-Ec---chhhHHHHHHHHHHHcCCCCc Confidence 77888888887678889999985432 3466778888887764 34332111 11 1123334444442 123678 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~ 299 (908) +|++.. +..+..+++++++.|+ T Consensus 205 ~i~~~~-~~~a~~~~~~l~~~g~ 226 (305) T 3HUU_C 205 VIITSD-VMLNMQLLNVLYEYQL 226 (305) T ss_dssp EEEESS-HHHHHHHHHHHHHTTC T ss_pred EEEECC-HHHHHHHHHHHHHcCC Confidence 775553 4456778888887776 No 258 >3KKE_C LacI family Transcriptional regulator; STRUCTURAL GENOMICS, TRANSCRIPTION, DNA-binding, Transcription; HET: ACT; 2.2A {Mycobacterium smegmatis str. MC2 155} Probab=96.87 E-value=2.5e-06 Score=85.91 Aligned_cols=205 Identities=12% Similarity=0.124 Sum_probs=117.5 Template_Neff=11.700 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++..+||++.|..+. .++..+..+++.++++. |++ +.+.+.. +. ....+. T Consensus 10 l~~~~~~~I~~v~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~--~~~~~~~-~~----~~~~~~ 62 (303) T 3KKE_C 10 LRHSRSGTIGLIVPDVNN------------AVFADMFSGVQMAASGH--------STD--VLLGQID-AP----PRGTQQ 62 (303) T ss_dssp CCTTCSCEEEEECSCTTS------------TTHHHHHHHHHHHHHHT--------TCE--EEEECCC-ST----THHHHH T ss_pred HhcCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHhcC--------CCE--EEEEeCC-CC----hhHHHH Confidence 345678999999987542 24566777887777664 233 3333322 21 112223 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +.+++. ..++|++|+...+.........+ ..++|+|..+...+ +..+.+..++ T Consensus 63 ~~~~~~------------------~~~~d~ii~~~~~~~~~~~~~~~-~~~ipvv~~~~~~~--------~~~~~v~~d~ 115 (303) T 3KKE_C 63 LSRLVS------------------EGRVDGVLLQRREDFDDDMLAAV-LEGVPAVTINSRVP--------GRVGSVILDD 115 (303) T ss_dssp HHHHHH------------------TTSCSEEEEECCTTCCHHHHHHH-HTTSCEEEESCCCT--------TSCCEEEECH T ss_pred HHHHHH------------------cCCCCEEEEeccccCCHHHHHHH-HhCCCEEEeCCCCC--------CCCCEEEeCc Confidence 333322 14688888654433222333444 67999998776432 1355677777 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE------ 271 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~------ 271 (908) ...++.+++++.+.+.++++++..+. .....+.++|++.+++. ++.+.....+..+.+..+..+.++++++ T Consensus 116 ~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~ 194 (303) T 3KKE_C 116 QKGGGIATEHLITLGHSRIAFISGTAIHDTAQRRKEGYLETLASA-GLRSEAAWVVDAGWEADAGSAALNTLYRGANLGK 194 (303) T ss_dssp HHHHHHHHHHHHHHTCCCEEEECSCTTCHHHHHHHHHHHHHHHHH-TCCCCGGGEECCCSSHHHHHHHHHHHHHHSCTTS T ss_pred hHHHHHHHHHHHHcCCCcEEEEeCCCCChHHHHHHHHHHHHHHHc-CCCCCceeEEecCCChHHHHHHHHHHHhhcCCCC Confidence 77888888888777888999998543 35566778888888765 3332211111100111223344444432 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ..++++|++.. +..+..+++++++.|+. T Consensus 195 ~~~~~~i~~~~-~~~a~~~~~a~~~~g~~ 222 (303) T 3KKE_C 195 PDGPTAVVVAS-VNAAVGALSTALRLGLR 222 (303) T ss_dssp TTSCSEEEESS-HHHHHHHHHHHHHHTCC T ss_pred CCCCCEEEECC-HHHHHHHHHHHHHCCCC Confidence 13577777664 44566778888877763 No 259 >3KKE_B LacI family Transcriptional regulator; STRUCTURAL GENOMICS, TRANSCRIPTION, DNA-binding, Transcription; HET: ACT; 2.2A {Mycobacterium smegmatis str. MC2 155} Probab=96.87 E-value=2.5e-06 Score=85.91 Aligned_cols=205 Identities=12% Similarity=0.124 Sum_probs=117.5 Template_Neff=11.700 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++..+||++.|..+. .++..+..+++.++++. |++ +.+.+.. +. ....+. T Consensus 10 l~~~~~~~I~~v~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~--~~~~~~~-~~----~~~~~~ 62 (303) T 3KKE_B 10 LRHSRSGTIGLIVPDVNN------------AVFADMFSGVQMAASGH--------STD--VLLGQID-AP----PRGTQQ 62 (303) T ss_dssp HHHTCCSEEEEECSCTTS------------TTHHHHHHHHHHHHHHT--------TCE--EEEECCC-ST----THHHHH T ss_pred HhcCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHhcC--------CCE--EEEEeCC-CC----hhHHHH Confidence 345678999999987542 24566777887777664 233 3333322 21 112223 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +.+++. ..++|++|+...+.........+ ..++|+|..+...+ +..+.+..++ T Consensus 63 ~~~~~~------------------~~~~d~ii~~~~~~~~~~~~~~~-~~~ipvv~~~~~~~--------~~~~~v~~d~ 115 (303) T 3KKE_B 63 LSRLVS------------------EGRVDGVLLQRREDFDDDMLAAV-LEGVPAVTINSRVP--------GRVGSVILDD 115 (303) T ss_dssp HHHHHH------------------TTSCSCEEECCCTTCCHHHHHHH-HTTSCEEEESCCCT--------TSCCEEEECH T ss_pred HHHHHH------------------cCCCCEEEEeccccCCHHHHHHH-HhCCCEEEeCCCCC--------CCCCEEEeCc Confidence 333322 14688888654433222333444 67999998776432 1355677777 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE------ 271 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~------ 271 (908) ...++.+++++.+.+.++++++..+. .....+.++|++.+++. ++.+.....+..+.+..+..+.++++++ T Consensus 116 ~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~ 194 (303) T 3KKE_B 116 QKGGGIATEHLITLGHSRIAFISGTAIHDTAQRRKEGYLETLASA-GLRSEAAWVVDAGWEADAGSAALNTLYRGANLGK 194 (303) T ss_dssp HHHHHHHHHHHHHTTCCSEEEEESCTTCHHHHHHHHHHHHHHHHT-TCCCCGGGEEECCSSHHHHHHHHHHHHHHHCTTS T ss_pred hHHHHHHHHHHHHcCCCcEEEEeCCCCChHHHHHHHHHHHHHHHc-CCCCCceeEEecCCChHHHHHHHHHHHhhcCCCC Confidence 77888888888777888999998543 35566778888888765 3332211111100111223344444432 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ..++++|++.. +..+..+++++++.|+. T Consensus 195 ~~~~~~i~~~~-~~~a~~~~~a~~~~g~~ 222 (303) T 3KKE_B 195 PDGPTAVVVAS-VNAAVGALSTALRLGLR 222 (303) T ss_dssp TTSCSEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CCCCCEEEECC-HHHHHHHHHHHHHCCCC Confidence 13577777664 44566778888877763 No 260 >3BBL_A Regulatory protein of LacI family; Protein Structure Initiative II, PSI-II; HET: EDO; 2.35A {Chloroflexus aggregans} Probab=96.86 E-value=2.6e-06 Score=84.93 Aligned_cols=146 Identities=13% Similarity=0.134 Sum_probs=85.5 Template_Neff=11.700 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++|++|+...... ......+...++|+|..+...+ .+..+.+.+++...++.+++++.+.+.++++++..+ T Consensus 63 ~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~~~~~~~~~l~~~g~~~i~~i~~~ 134 (287) T 3BBL_A 63 GNVDGFVLSSINYN-DPRVQFLLKQKFPFVAFGRSNP-------DWDFAWVDIDGTAGTRQAVEYLIGRGHRRIAILAWP 134 (287) T ss_dssp TCCSEEEECSCCTT-CHHHHHHHHTTCCEEEESCCST-------TCCCCEEEECHHHHHHHHHHHHHHHTCCCEEEEECC T ss_pred CCCCEEEEecCCCC-CHHHHHHHhCCCCEEEeCCCCC-------CCCCcEEEeChHHHHHHHHHHHHHCCCCcEEEEeCC Confidence 47888887544332 2344556678999998775432 123556667777777788888866678899998844 Q NP_000836.2 225 G--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET---PNARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 225 ~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~---~~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) . .....+.+++.+.+++. ++.+..........+..+....++++++. .++|+|++.. +..+..+++++++.|+ T Consensus 135 ~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~i~~~~-~~~~~~~~~~l~~~g~ 212 (287) T 3BBL_A 135 EDSRVGNDRLQGYLEAMQTA-QLPIETGYILRGEGTFEVGRAMTLHLLDLSPERRPTAIMTLN-DTMAIGAMAAARERGL 212 (287) T ss_dssp TTCHHHHHHHHHHHHHHHHT-TCCCCGGGEEECCSSHHHHHHHHHHHHTSCTTTSCSEEEESS-HHHHHHHHHHHHHTTC T ss_pred ccchHHHHHHHHHHHHHHHC-CCCCCCcceeccCCCHHHHHHHHHHHHccCCCCCCCEEEECC-HHHHHHHHHHHHHCCC Confidence 2 24556677788777764 33322111111001111233334444321 2467777664 4456778888888776 Q NP_000836.2 300 S 300 (908) Q Consensus 300 ~ 300 (908) . T Consensus 213 ~ 213 (287) T 3BBL_A 213 T 213 (287) T ss_dssp C T ss_pred C Confidence 4 No 261 >4PZ0_A sugar ABC transporter, sugar-binding protein; structural genomics, The Center for; HET: PAV, EDO; 1.25A {Bacillus anthracis} Probab=96.85 E-value=2.8e-06 Score=86.62 Aligned_cols=213 Identities=13% Similarity=0.078 Sum_probs=116.2 Template_Neff=11.400 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILD-TCSRDTYALEQSLTF 119 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d-~~~~~~~a~~~~~~~ 119 (908) ...+.++||++.|..+. .++..+..+++.++++. |++ +.+.+ +..++ ....+. T Consensus 6 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~--~~~~~~~~~~~----~~~~~~ 59 (324) T 4PZ0_A 6 KKADDVKFAFIPKLTGV------------GFFTSGGEGAKEMGDKL--------GVQ--VKYDGPSEASV----SGQVKY 59 (324) T ss_dssp SCGGGCEEEEECSSSSS------------HHHHHHHHHHHHHHHHH--------TCE--EEECCCSSCCH----HHHHHH T ss_pred hccCCcEEEEEeCCCCC------------hHHHHHHHHHHHHHHHH--------CCE--EEEECCCCCCH----HHHHHH Confidence 45678999999986542 25567778888887764 233 33344 22232 223334 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+.. .......+...++|+|..+...+. ....+.+..+ T Consensus 60 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~~ 114 (324) T 4PZ0_A 60 INNFIN-------------------QNYDALMVSSTSVDGLSQSLQRAKKKGMTVLTWDSDVNP------KDRSFYISQG 114 (324) T ss_dssp HHHHHH-------------------TTCSEEEECCSCSSTTHHHHHHHHHTTCEEEEESSCCCG------GGCSEEEESC T ss_pred HHHHHh-------------------cCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCc------ccCcEEEecC Confidence 444332 47888776543332 224455677789999987764431 1122333344 Q NP_000836.2 199 D-SYQAQAMVDIVTAL-G-WNYVSTLAS--EGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 199 ~-~~~~~~~~~~l~~~-~-~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) + ...++.+++++.+. + .++++++.. ++.+...+.+++++.+++.+ ++++....... .+..+....+++++.. T Consensus 115 ~~~~~g~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~ 192 (324) T 4PZ0_A 115 TPDQLANLLIEMTSKQIGDKGKVAFFYSSPTVTDQNQWVTKAKEIIKEKYPNWEIVTTQYGE--NNAQKSLSVGENILKT 192 (324) T ss_dssp CHHHHHHHHHHHHHHHHTTCEEEEEEESCSSCHHHHHHHHHHHHHHHHHCTTEEEEEEEECT--TCHHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHHCCCeeEEEEEcCCCCHHHHHHHHHHHHHHHHHCCCcEEeeeccCC--CCHHHHHHHHHHHHHH Confidence 3 45566777777543 4 678988874 33455667777887776521 13332211111 1112334445555421 Q NP_000836.2 273 -PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIG 307 (908) Q Consensus 273 -~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~ 307 (908) .++++|++. ++..+..+++++++.|+..++.+++ T Consensus 193 ~~~~~~i~~~-~~~~a~~~~~al~~~g~~~~i~v~g 227 (324) T 4PZ0_A 193 YPDINAVICP-DATALPAMAQAAENLKMDKKVVVTG 227 (324) T ss_dssp CTTCCEEEEC-STTHHHHHHHHHHHTTCBTTBEEEE T ss_pred CCCCCEEEec-CCcchHHHHHHHHHCCCCCCeEEEE Confidence 246666655 3445667778888777632333443 No 262 >4YS6_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; ABC TRANSPORTER, SOLUTE-BINDING PROTEIN, ENZYME; HET: BGC, MSE; 1.698A {Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)} Probab=96.85 E-value=2.8e-06 Score=88.09 Aligned_cols=217 Identities=9% Similarity=0.018 Sum_probs=115.7 Template_Neff=11.100 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+.++||++.|..+. .++.....+++.++++.| +++.+.|...+. +...+. T Consensus 31 ~~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~l~~~~~~~~~----~~~~~~ 84 (360) T 4YS6_A 31 SGKGSDKLVGVAMPTKDL------------QRWNQDGSNMEKQLKDAG----------YEVDLQYASNDV----QTQVSQ 84 (360) T ss_dssp ------CEEEEEESCSSS------------THHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHH T ss_pred CCCCCCcEEEEEecCCCC------------HHHHhhHHHHHHHHHHcC----------CEEEEEeCCCCH----HHHHHH Confidence 456678999999987542 245567778887777653 344445544332 222333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAA-SSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~-s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. .+++++|.... +.........+...++|+|..+...+. ..++.+++.++ T Consensus 85 i~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~d 140 (360) T 4YS6_A 85 IENMIS-------------------NGCKLLVIASIEGDSLGTVLAQAKKKGISVIAYDRLIMN-----SDAVSYYATFD 140 (360) T ss_dssp HHHHHH-------------------TTCSEEEECCSSTTSCHHHHHHHHHTTCEEEEESSCCCS-----CTTCCEEEEEC T ss_pred HHHHHH-------------------CCCCEEEEeCCCcccHHHHHHHHHHCCCEEEEECCCCCC-----CCcccEEEEeC Confidence 444332 46777765432 222234455667789999987654331 12346677777 Q NP_000836.2 199 DSYQAQAMVDIVTAL-------GWNYVSTLAS--EGNYGESGVEAFTQISREIGG--VCIAQS------QKIPREPRPGE 261 (908) Q Consensus 199 ~~~~~~~~~~~l~~~-------~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~--i~v~~~------~~~~~~~~~~~ 261 (908) +...++.+++++.+. +.++++++.. ++.++..+.+++++.+++.++ +.+... .......+..+ T Consensus 141 ~~~~~~~~~~~l~~~~~~~~~~g~~~v~~i~~~~~~~~~~~r~~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~ 220 (360) T 4YS6_A 141 NYMVGTKQGEYIKEKLNLETAKGPFNLEIFTGDPGDNNARFFYGGAMDVLKPYVDGGVLVVKSGSVAFEKVATAGWSTET 220 (360) T ss_dssp HHHHHHHHHHHHHHHTTTTTCCCCEEEEEEBCCTTCHHHHHHHHHHHHHHHHHHHTTSEECTTCCCSHHHHBCGGGCHHH T ss_pred hHHHHHHHHHHHHHHhccccCCCCceEEEEEcCCCChhHHHHHhHHHHHhHhhcCCCeEEEecCceeeeeeccCCCCHHH Confidence 777777777777543 6779999985 345566777888887766421 221100 00000011111 Q NP_000836.2 262 FEKIIKRLLET-----PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIG 307 (908) Q Consensus 262 ~~~~~~~l~~~-----~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~ 307 (908) ....+++++.+ .++|+|++.. +..+..+++++++.|+..++.+++ T Consensus 221 ~~~~~~~~l~~~~~~~~~~d~i~~~~-~~~a~~~~~al~~~g~~~~i~v~~ 270 (360) T 4YS6_A 221 AQNRMDAIIASYYADGTKLDAVLCSN-DSTALGVTNALTASYKGEWPIVTG 270 (360) T ss_dssp HHHHHHHHHHHHSSSSCCCCEEEESS-HHHHHHHHHHHHHHCCSSCCEECC T ss_pred HHHHHHHHHHHhhccCCCceEEEECC-hHHHHHHHHHHHHcCCCCCCEEEE Confidence 11223333211 3567776654 445667788888777632333443 No 263 >3L49_C ABC sugar (Ribose) transporter, periplasmic; SUGAR BINDING/TRANSPORTER, STRUCTURAL GENOMICS, PSI; HET: UNL; 2.3A {Rhodobacter sphaeroides} Probab=96.84 E-value=2.9e-06 Score=84.69 Aligned_cols=203 Identities=12% Similarity=0.091 Sum_probs=110.6 Template_Neff=11.900 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) ++.++||++.|.... ........+++.++++.| +++.+.|+..++. ...+.+++ T Consensus 3 ~~~~~Ig~~~~~~~~------------~~~~~~~~~~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~~ 56 (291) T 3L49_C 3 LEGKTIGITAIGTDH------------DWDLKAYQAQIAEIERLG----------GTAIALDAGRNDQ----TQVSQIQT 56 (291) T ss_dssp CTTCEEEEEESCCCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECCSCHH----HHHHHHHH T ss_pred CCCcEEEEEecCCCC------------HHHHHHHHHHHHHHHHCC----------CEEEEEeCCCCHH----HHHHHHHH Confidence 467899999985432 234456667776666543 3444555443322 22233443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAA-ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. ++++++|+.. .+.........+...++|+|..+...+ ..++++.+++.. T Consensus 57 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~--------~~~~~v~~~~~~ 109 (291) T 3L49_C 57 LIA-------------------QKPDAIIEQLGNLDVLNPWLQKINDAGIPLFTVDTATP--------HAINNTTSNNYS 109 (291) T ss_dssp HHH-------------------TCCSEEEEECCCHHHHHHHHHHHHHTTCCEEEESCCCT--------TCSEEEECCHHH T ss_pred HHH-------------------cCCCEEEEcCCChhhhHHHHHHHHHCCCCEEEeCCCCC--------CccceeccChHH Confidence 332 4788888653 333323445556778999998775432 134555555555 Q NP_000836.2 202 QAQAM-VDIVTALGWN-YVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIP-REPRPGEFEKIIKRLLET-P-- 273 (908) Q Consensus 202 ~~~~~-~~~l~~~~~~-~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~-~~~~~~~~~~~~~~l~~~-~-- 273 (908) .+..+ ..++.+.+.+ +++++.. ++.++..+.+++++.+++.+++++....... ...+..+....++++++. . T Consensus 110 ~~~~~~~~~~~~~g~~~~v~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 189 (291) T 3L49_C 110 IGAELALQMVADLGGKGNVLVFNGFYSVPVCKIRYDQMKYVLEAFPDVKIIEPELRDVIPNTIQSAYSNVTDMLTKYPNE 189 (291) T ss_dssp HHHHHHHHHHHHTTTCEEEEEECTTTTSHHHHHHHHHHHHHHTTCTTEEECSSCBCCCSSSHHHHHHHHHHHHHHHCCST T ss_pred HHHHHHHHHHHHhCCCceEEEEEcCCCCHHHHHHHHHHHHHHHHCCCcEEeccccccCCCCCHHHHHHHHHHHHHHCCCC Confidence 55433 3444555666 7888875 3445666777887777653223332211000 001112334445555431 1 Q NP_000836.2 274 -NARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 274 -~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) ++++|++.. +..+..+++++++.|+ T Consensus 190 ~~~dai~~~~-~~~a~~~~~~l~~~g~ 215 (291) T 3L49_C 190 GDVGAIWACW-DVPMIGATQALQAAGR 215 (291) T ss_dssp TSCCEEEESS-SHHHHHHHHHHHHHTC T ss_pred CCccEEEEcC-CHHHHHHHHHHHHCCC Confidence 567777664 4456677888887776 No 264 >3JY6_A Transcriptional regulator, LacI family; NYSGXRC, PSI-II, transcriptional regulator, Lac; 1.97A {Lactobacillus brevis} Probab=96.83 E-value=3e-06 Score=83.95 Aligned_cols=199 Identities=11% Similarity=0.090 Sum_probs=113.6 Template_Neff=11.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++..+||++.|..+. .++.....+++.++++.+ + ++.+.+...+. ....+.++ T Consensus 4 ~~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~~ 57 (276) T 3JY6_A 4 TQSSKLIAVIVANIDD------------YFSTELFKGISSILESRG--------Y--IGVLFDANADI----EREKTLLR 57 (276) T ss_dssp -CCCCEEEEEESCTTS------------HHHHHHHHHHHHHHHTTT--------C--EEEEEECTTCH----HHHHHHHH T ss_pred cCCccEEEEEEcCCCC------------hHHHHHHHHHHHHHHHcC--------C--EEEEEeCCCCH----HHHHHHHH Confidence 4567899999986532 245567778887776643 2 23344443332 12223333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) .+.. .++|++|+...+.. .....+...++|+|..+...+ .+..+.+..++.. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~--~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 109 (276) T 3JY6_A 58 AIGS-------------------RGFDGLILQSFSNP--QTVQEILHQQMPVVSVDREMD-------ACPWPQVVTDNFE 109 (276) T ss_dssp HHHT-------------------TTCSEEEEESSCCH--HHHHHHHTTSSCEEEESCCCT-------TCSSCEEECCHHH T ss_pred HHHH-------------------cCCCEEEEecCCCc--HHHHHHHhCCCCEEEeCCCCC-------CCCCCeEEeChHH Confidence 3332 47888887544332 233445678999988765432 1245566677777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNY---GESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~---~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) .++.+++++.+.+.++++++.....+ ...+.+++.+.+++. ++.......+ +..+....+++++. ..++++ T Consensus 110 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~----~~~~~~~~~~~~l~~~~~~~~ 184 (276) T 3JY6_A 110 AAKAATTAFRQQGYQHVVVLTSELELSRTRQERYRGILAAAQDV-DVLEVSESSY----NHSEVHQRLTQLITQNDQKTV 184 (276) T ss_dssp HHHHHHHHHHTTTCCEEEEEEECSTTCHHHHHHHHHHHTTCSEE-EEEEECSSSC----CHHHHHHHHHHHHHSSSSCEE T ss_pred HHHHHHHHHHHCCCCEEEEEcCccccchhHHHHHHHHHHHHHhC-CCeEeeccCC----CHHHHHHHHHHHHhcCCCCcE Confidence 77788888766678899998854332 455667777776654 3322111111 11223344555542 135677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 185 i~~~~-~~~a~~~~~~l~~~g~~ 206 (276) T 3JY6_A 185 AFALK-ERWLLEFFPNLIISGLI 206 (276) T ss_dssp EEESS-HHHHHHHSHHHHHSSSC T ss_pred EEEcC-hHHHHHHHHHHHHcCCC Confidence 76653 44566677777777763 No 265 >3JY6_D Transcriptional regulator, LacI family; NYSGXRC, PSI-II, transcriptional regulator, Lac; 1.97A {Lactobacillus brevis} Probab=96.83 E-value=3e-06 Score=83.95 Aligned_cols=199 Identities=11% Similarity=0.090 Sum_probs=111.5 Template_Neff=11.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++..+||++.|..+. .++.....+++.++++.+ + ++.+.+...+. ....+.++ T Consensus 4 ~~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~~ 57 (276) T 3JY6_D 4 TQSSKLIAVIVANIDD------------YFSTELFKGISSILESRG--------Y--IGVLFDANADI----EREKTLLR 57 (276) T ss_dssp ----CEEEEEESCTTS------------HHHHHHHHHHHHHHHTTT--------C--EEEEEECTTCH----HHHHHHHH T ss_pred cCCccEEEEEEcCCCC------------hHHHHHHHHHHHHHHHcC--------C--EEEEEeCCCCH----HHHHHHHH Confidence 4567899999986532 245567778887776643 2 23344443332 12223333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) .+.. .++|++|+...+.. .....+...++|+|..+...+ .+..+.+..++.. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~--~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 109 (276) T 3JY6_D 58 AIGS-------------------RGFDGLILQSFSNP--QTVQEILHQQMPVVSVDREMD-------ACPWPQVVTDNFE 109 (276) T ss_dssp HHHH-------------------TTCSEEEECSSCCH--HHHHHHSCSCCCEEEESSCCS-------SCSSCEEEECHHH T ss_pred HHHH-------------------cCCCEEEEecCCCc--HHHHHHHhCCCCEEEeCCCCC-------CCCCCeEEeChHH Confidence 3332 47888887544332 233445678999988765432 1245566677777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNY---GESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~---~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) .++.+++++.+.+.++++++.....+ ...+.+++.+.+++. ++.......+ +..+....+++++. ..++++ T Consensus 110 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~----~~~~~~~~~~~~l~~~~~~~~ 184 (276) T 3JY6_D 110 AAKAATTAFRQQGYQHVVVLTSELELSRTRQERYRGILAAAQDV-DVLEVSESSY----NHSEVHQRLTQLITQNDQKTV 184 (276) T ss_dssp HHHHHHHHHHTTTCCEEEEEEECGGGCHHHHHHHHHHHTTCSEE-EEEEECTTCC-----CHHHHHHHHHHHHSSCCCEE T ss_pred HHHHHHHHHHHCCCCEEEEEcCccccchhHHHHHHHHHHHHHhC-CCeEeeccCC----CHHHHHHHHHHHHhcCCCCcE Confidence 77788888766678899998854332 455667777776654 3322111111 11223344555542 135677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 185 i~~~~-~~~a~~~~~~l~~~g~~ 206 (276) T 3JY6_D 185 AFALK-ERWLLEFFPNLIISGLI 206 (276) T ss_dssp EEESS-HHHHHHHSHHHHHSSCC T ss_pred EEEcC-hHHHHHHHHHHHHcCCC Confidence 76653 44566677777777763 No 266 >5HQJ_A Periplasmic binding protein/LacI transcriptional regulator; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: 64K, MSE; 1.55A {Burkholderia graminis C4D1M} Probab=96.83 E-value=3e-06 Score=85.67 Aligned_cols=204 Identities=10% Similarity=0.095 Sum_probs=114.8 Template_Neff=11.700 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+.++||++.+.+. .++..+..+++.++++.+ +++.+...++ .++ +...+. T Consensus 23 ~~~~~~~~Ig~~~~~~~-------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~~~~~~ 76 (311) T 5HQJ_A 23 MKDAKDISVAVIPKVAV-------------PFFDDCNKGAKTAADKAG--------VKYQWVVPQN-TQG----STQVQI 76 (311) T ss_dssp CCCGGGCEEEEECSSSC-------------TTHHHHHHHHHHHHHHHT--------CEEEECCCSS-SSS----HHHHHH T ss_pred cccCCCceEEEecCCCC-------------HHHHHHHHHHHHHHHHHC--------CEEEEECCCC-CCH----HHHHHH Confidence 34567899999665432 245677888888888763 3444433332 221 122333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVI-GAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++| ++..+.........+...++|+|..+...+. .++.+++.++ T Consensus 77 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d 131 (311) T 5HQJ_A 77 IEDLIS-------------------RHVDGIAISVNEPKSVESVMKRAEQSGIKVLTYDSDSPK------SGRSMYIGTN 131 (311) T ss_dssp HHHHHH-------------------TTCSEEEECCSSTGGGHHHHHHHHTTTCEEEEESSCCTT------SCCSCEEECC T ss_pred HHHHHH-------------------cCCCEEEEcCCCHHHHHHHHHHHHHcCCeEEEEcCCCCC------CCCcEEEecC Confidence 444332 4678775 4443333233445566789999987764321 2456677777 Q NP_000836.2 199 DSYQAQAMVDIVTA--LGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TP 273 (908) Q Consensus 199 ~~~~~~~~~~~l~~--~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~ 273 (908) ....++.+++++.+ .+.++++++.. +..+...+.+++++.+++..++++....... .+..+....+++++. .. T Consensus 132 ~~~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 209 (311) T 5HQJ_A 132 NEQAGATMAETMGKALNGQGEVAIITGQLGAVNLNERIAGIKKGLAKYPGIKVVETQGTD--DDLARGVSVVETTLRAHP 209 (311) T ss_dssp HHHHHHHHHHHHHHHTTTEEEEEEECSCTTCHHHHHHHHHHHHHHTTCTEEEEEEEECCT--TCHHHHHHHHHHHHHHCT T ss_pred HHHHHHHHHHHHHHHcCCCeeEEEEECCCCCccHHHHHHHHHHHHHhCCCcEEEEecCCC--ccHHHHHHHHHHHHHHCC Confidence 77778888888765 57789999985 3445666777888877653124443221111 111223344444442 12 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKL 297 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~ 297 (908) ++++|++.. +..+..+++++++. T Consensus 210 ~~~~i~~~~-~~~a~~~~~~~~~~ 232 (311) T 5HQJ_A 210 NLKGIFGVS-QVGGPAVAKVLNTR 232 (311) T ss_dssp TEEEEEECS-TTHHHHHHHHHTST T ss_pred CccEEEEec-CCcHHHHHHHHHHH Confidence 567776654 33445566666543 No 267 >3EJW_A SmLsrB; Periplasmic binding protein, Plasmid, SIGNALING; HET: PAV; 1.8A {Sinorhizobium meliloti} Probab=96.81 E-value=3.3e-06 Score=85.59 Aligned_cols=211 Identities=10% Similarity=-0.016 Sum_probs=114.6 Template_Neff=11.400 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++..+..+++.++++.+ +++.+...+ ..++ +...+.+++++ T Consensus 1 ~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~-~~~~----~~~~~~~~~l~ 55 (315) T 3EJW_A 1 ENQIAFIPKLVGV------------GFFTSGGAGAVKAGEEVG--------AKVTYDGPT-EPSV----SGQVQFINNFV 55 (315) T ss_dssp CCEEEEECSCSSS------------HHHHHHHHHHHHHHHHHT--------CEEEECCCS-SCCH----HHHHHHHHHHH T ss_pred CcEEEEEeccCCC------------hHHHHHHHHHHHHHHHHC--------CEEEEECCC-CCCH----HHHHHHHHHHH Confidence 3689999987652 255677888888888763 334333221 2222 22333444443 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP-PDSYQ 202 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~-~~~~~ 202 (908) . ++++++|+...+.. .......+...++|+|..+...+. ....+.+.. +.... T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~~~~~~~ 110 (315) T 3EJW_A 56 N-------------------QGYNALIVSSVSPDGLCPALKRAMERGVLVMTWDSDVNP------DCRSYYINQGTPEQL 110 (315) T ss_dssp H-------------------TTCSEEEECCSCSSTTHHHHHHHHHTTCEEEEESSCCCG------GGCSEEEESCCHHHH T ss_pred H-------------------cCCCEEEEcCCChhhhHHHHHHHHHCCCEEEEEcCCCCc------ccccEEEeCCCHHHH Confidence 2 47888776543322 224455667789999987764431 111222333 45555 Q NP_000836.2 203 AQAMVDIVTAL--G-WNYVSTLAS--EGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNA 275 (908) Q Consensus 203 ~~~~~~~l~~~--~-~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~ 275 (908) ++.+++++.+. + .++++++.. ++.++..+.++|++.+++.+ ++++....... .+..+....++++++ ..++ T Consensus 111 g~~~~~~l~~~~~~~~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~ 188 (315) T 3EJW_A 111 GGLLVDMAAEGVKKEKAKVAFFYSSPTVTDQNAWAEAAKAKIAKEHPGWEIVTTQYGY--NDAQKSLQTAESILQTYPDL 188 (315) T ss_dssp HHHHHHHHHHHHCCSSEEEEEEESCSSCHHHHHHHHHHHHHHHHHCTTEEEEEEEECT--TCHHHHHHHHHHHHHHCTTC T ss_pred HHHHHHHHHHHcccCCCcEEEEEcCCCcHHHHHHHHHHHHHHHHHCCCcEEeecccCC--CCHHHHHHHHHHHHHHCCCC Confidence 66777776443 3 688998875 34456667778888776531 23332211111 111233344555542 1256 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|+... +..+..+++++++.|+..++.+++. T Consensus 189 ~~i~~~~-~~~a~~~~~al~~~g~~~~v~v~~~ 220 (315) T 3EJW_A 189 DAIIAPD-ANALPAAAQAAENLKRAEGVTIVGF 220 (315) T ss_dssp CEEEECS-TTHHHHHHHHHHHHTCTTTCEEEEB T ss_pred CEEEeCC-CCchHHHHHHHHHcccCCCCEEEEe Confidence 6666553 4456677888888776323444443 No 268 >3QK7_C Transcriptional regulators; STRUCTURAL GENOMICS, NEW YORK STRUCTURAL; 2.7A {Yersinia pestis} Probab=96.81 E-value=3.3e-06 Score=84.46 Aligned_cols=207 Identities=11% Similarity=0.100 Sum_probs=115.7 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .+++.+||++.|.++... ...+...+..+++.++++.+ +++ .+.+.. +. +...+.++ T Consensus 3 ~~~~~~I~~i~~~~~~~~--------~~~~~~~~~~~~~~~~~~~g--------~~~--~~~~~~-~~----~~~~~~~~ 59 (294) T 3QK7_C 3 LGRTDAIALAYPSRPRVL--------NNSTFLEMISWIGIELGKRG--------LDL--LLIPDE-PG----EKYQSLIH 59 (294) T ss_dssp --CCCEEEEEEESSSGGG--------CCHHHHHHHHHHHHHHHTTT--------CEE--EEEEEC-TT----CCCHHHHH T ss_pred CCCCCeEEEEecCCchhh--------cCHHHHHHHHHHHHHHHHcC--------CeE--EEEeCC-Ch----hHHHHHHH Confidence 356789999998643100 01244566677777666542 333 333322 21 12223333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++.. .++|++|....+... .....+...++|+|..+...+ .+.++.+.++... T Consensus 60 ~~~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 112 (294) T 3QK7_C 60 LVET-------------------RRVDALIVAHTQPED-FRLQYLQKQNFPFLALGRSHL-------PKPYAWFDFDNHA 112 (294) T ss_dssp HHHT-------------------TCCSEEEECSCCSSC-HHHHHHHHTTCCEEEESCCCC-------SSCCEEEEECHHH T ss_pred HHHh-------------------CCCCEEEEeCCCCCc-HHHHHHHHCCCCEEEECCCCC-------CCCCeEEEeChHH Confidence 3322 478888865444333 344556668999998775432 1345667777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .++.+++++.+.+.++++++..+. .....+.+++++.+++. ++.+..........+..+....++++++ ..++|+| T Consensus 113 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d~i 191 (294) T 3QK7_C 113 GASLAVKRLLELGHQRIAFVSTDARISYVDQRLQGYVQTMSEA-GLMPLAGYLQKADPTRPGGYLAASRLLALEVPPTAI 191 (294) T ss_dssp HHHHHHHHHHHTTCCSEEEEEECSCSHHHHHHHHHHHHHHHHT-TCCCCTTCEEEECSSHHHHHHHHHHHHTSSSCCSEE T ss_pred HHHHHHHHHHHCCCCeEEEEeCCCCCcHHHHHHHHHHHHHHHC-CCCCcccceecCCCCchHHHHHHHHHHcCCCCCCEE Confidence 788888888767888999988532 34556777888887765 3433211111100111223344555542 1357777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 192 ~~~~-~~~a~~~~~~l~~~g~~ 212 (294) T 3QK7_C 192 ITDC-NMLGDGVASALDKAGLL 212 (294) T ss_dssp EESS-HHHHHHHHHHHHHHTCB T ss_pred EECC-cHHHHHHHHHHHHcCCC Confidence 7654 44566778888877763 No 269 >3E3M_D Transcriptional regulator, LacI family; STRUCTURAL GENOMICS, TRANSCRIPTION, DNA-binding, Plasmid; 1.6A {Silicibacter pomeroyi} Probab=96.81 E-value=3.3e-06 Score=87.29 Aligned_cols=204 Identities=13% Similarity=0.136 Sum_probs=115.2 Template_Neff=11.300 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++..+||+++|..+. .++.....+++.++++.+ + ++.+.+...++ +...+.++ T Consensus 67 ~~~~~~I~~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~~ 120 (355) T 3E3M_D 67 TKRSGFVGLLLPSLNN------------LHFAQTAQSLTDVLEQGG--------L--QLLLGYTAYSP----EREEQLVE 120 (355) T ss_dssp ----CEEEEEESCSBC------------HHHHHHHHHHHHHHHHTT--------C--EEEEEECTTCH----HHHHHHHH T ss_pred cCCCCEEEEEecCCCC------------hhHHHHHHHHHHHHHHCC--------C--EEEEEeCCCCh----HHHHHHHH Confidence 3567899999986532 245566777777665542 2 33344443332 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+.... ........+.+.++|+|..+...+ .+..+++..++.. T Consensus 121 ~~~~-------------------~~~d~ii~~~~~-~~~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 173 (355) T 3E3M_D 121 TMLR-------------------RRPEAMVLSYDG-HTEQTIRLLQRASIPIVEIWEKPA-------HPIGHTVGFSNER 173 (355) T ss_dssp HHHH-------------------TCCSEEEEECSC-CCHHHHHHHHTSCSCEEEESSCCS-------SCSSEEEECCHHH T ss_pred HHHH-------------------hCCCEEEEcCCC-CCHHHHHHHHHCCCCEEEEcCCCC-------CCCCcEEEeCHHH Confidence 3332 478888874322 233445566678999998875432 1345566777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIP-REPRPGEFEKIIKRLLE-TPNAR 276 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~-~~~~~~~~~~~~~~l~~-~~~~~ 276 (908) .+..+++++.+.+.++|+++..... ....+.++|++.+++. ++.+....... ...+..+....+++++. ..++| T Consensus 174 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~r~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d 252 (355) T 3E3M_D 174 AAYDMTNALLARGFRKIVFLGEKDDDWTRGAARRAGFKRAMREA-GLNPDQEIRLGAPPLSIEDGVAAAELILQEYPDTD 252 (355) T ss_dssp HHHHHHHHHHHTTCCSEEEEEESSCTTSHHHHHHHHHHHHHHHT-TSCSCCEEEESCSSCCHHHHHHHHHHHHHHCTTCC T ss_pred HHHHHHHHHHHCCCCeEEEEcCCCCCchhHHHHHHHHHHHHHHC-CCCCCcceecCCCCCCHHHHHHHHHHHHHHCCCCc Confidence 7778888876667889999875432 2456777888887765 34322111100 00111223344555442 13578 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +|++.. +..+..+++++++.|+. T Consensus 253 ai~~~~-~~~a~~~~~al~~~g~~ 275 (355) T 3E3M_D 253 CIFCVS-DMPAFGLLSRLKSIGVA 275 (355) T ss_dssp EEEESS-HHHHHHHHHHHHHHTCC T ss_pred EEEECC-cHHHHHHHHHHHHcCCC Confidence 787764 44566788888888763 No 270 >2WRZ_A L-ARABINOSE-BINDING PERIPLASMIC PROTEIN; SUGAR TRANSPORT, ARABINOSE BINDING PROTEIN; 2.2A {ESCHERICHIA COLI} Probab=96.80 E-value=3.5e-06 Score=84.89 Aligned_cols=206 Identities=12% Similarity=0.097 Sum_probs=109.7 Template_Neff=11.900 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++..+..+++.++++.| +++.+.+. .+. +...+.+++++ T Consensus 2 ~~~I~~i~~~~~~------------~~~~~~~~~~~~~~~~~~----------~~l~~~~~-~~~----~~~~~~~~~l~ 54 (306) T 2WRZ_A 2 NLKLGFLVAQPEE------------PASQTQWKFADKAGKDLG----------FEVIKIAV-PDG----EKTLNAIDSLA 54 (306) T ss_dssp CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT----------CEEEEEEC-SSH----HHHHHHHHHHH T ss_pred CeEEEEEeCCCCC------------hHHHHHHHHHHHHHHHhC----------CEEEEEeC-CCH----HHHHHHHHHHH Confidence 5789999987542 245667788888887753 23333343 221 22333444433 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGV-IGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~v-Ig~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++ +++..+.........+...++|+|..+...+.... ...++++++.+++...+ T Consensus 55 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~-~~~~~~~~v~~d~~~~~ 114 (306) T 2WRZ_A 55 A-------------------SGAKGFVISTPDPKLGSAIVAKARGYDMKVIAVDNQFVNAKG-KPMDTVPLVMEAATKIG 114 (306) T ss_dssp H-------------------HTCCEEEEECSCGGGHHHHHHHHHHTTCEEEEESSCCBCTTS-CBCCSSCEEECCHHHHH T ss_pred H-------------------CCCCEEEEeCCCcchhHHHHHHHHhCCCEEEEEcCcccCCCC-CCcccccEEecchHHHH Confidence 2 467774 44444433334455566789999988764432110 01234666777776667 Q NP_000836.2 204 QAMVDIVTA----LGWN--YVSTLAS---EGNYGESGVEAFTQISREIG--GVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 204 ~~~~~~l~~----~~~~--~v~ii~~---~~~~~~~~~~~~~~~~~~~~--~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) +.+++++.+ .+++ ++.++.. +..++..+.+++++.+++.+ ...+....... .+..+....++++++ T Consensus 115 ~~~~~~l~~~~~~~g~~~~~i~v~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~--~~~~~~~~~~~~~l~- 191 (306) T 2WRZ_A 115 ERQGQELYKEMQKRGWDVKESAVMAITANELDTARRRTTGSMDALKAAGFPEKQIYQVPTKS--EDIPGAFDAANSMLV- 191 (306) T ss_dssp HHHHHHHHHHHHHHTCCGGGEEEEEEECTTSHHHHHHHHHHHHHHHHTTCCGGGEEEEECSS--SSHHHHHHHHHHHHH- T ss_pred HHHHHHHHHHHHHcCCCccceEEEEEEcCCChhhHHHHHHHHHHHHHcCCCCceeEEecCCC--CChhHHHHHHHHHHH- Confidence 777766533 4555 6665542 22345567778888777642 01221111100 111233445555543 Q NP_000836.2 273 PNARA---VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 273 ~~~~v---iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) .+++. ++++.++..+..+++++++.|+. T Consensus 192 ~~~~~~~~~i~~~~~~~a~~~~~~l~~~g~~ 222 (306) T 2WRZ_A 192 QHPEVKHWLIVGMNDSTVLGGVRATEGQGFK 222 (306) T ss_dssp TCTTCSEEEEECSSHHHHHHHHHHHHHTTCC T ss_pred hCCCCceEEEEecChHHHHHHHHHHHhCCCC Confidence 23332 23333344566788888887764 No 271 >5BQ3_A Rhamnose ABC transporter, rhamnose-binding protein; ABC transporter, Structural Genomics, Joint; HET: MSE; 2.6A {Actinomyces odontolyticus ATCC 17982} Probab=96.78 E-value=3.7e-06 Score=85.92 Aligned_cols=218 Identities=11% Similarity=0.032 Sum_probs=115.3 Template_Neff=11.600 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNI-TLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~-~l~~~~~d~~~~~~~a~~~~~ 117 (908) .....+.++||++.|..+. .++.....+++.++++.+ + ++.+.. ++..++ .... T Consensus 21 ~~~~~~~~~Igv~~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~-~~~~~~----~~~~ 75 (332) T 5BQ3_A 21 GSYDVSSQSITFIPKQLNN------------PFSDVMLGGGKNAAGEIG--------FAEVNVVG-PLEASS----SSQV 75 (332) T ss_dssp CCCCCSSCEEEEECSSSSC------------HHHHHHHHHHHHHHHHHT--------CSEEEECC-CSSCCT----TTTH T ss_pred CcccCCCcEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC--------CcEEEEEC-CCCCCH----HHHH Confidence 4556778999999986542 245667778888887753 3 344433 332222 2223 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVI-GAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +.+++++. ++++++| ++..+.........+...++|+|..+...+. .....+... T Consensus 76 ~~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~v~~ 131 (332) T 5BQ3_A 76 SFINSEVQ-------------------AGTNVLVIAANDPDAVCPALQDARKAGTKVVTFDSDSAA-----DCRDLFINQ 131 (332) T ss_dssp HHHHHHHH-------------------TTCSEEEECCSSTTTSHHHHHHHHHHTCEEEEESSCCCT-----TSCSEEEES T ss_pred HHHHHHHH-------------------hCCCEEEEeCCCHHhhHHHHHHHHHcCCEEEEECCCCCc-----cccceeEec Confidence 33444332 4678744 4443333334445566789999987765431 011222222 Q NP_000836.2 197 PPDSYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISRE---IGGVCIAQSQKIPREPRPGEFEKIIKRL 269 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~---~~~i~v~~~~~~~~~~~~~~~~~~~~~l 269 (908) .+....++.+++++.+. +.++++++.. +..+...+.+.+++.+++ ..++++....... .+..+....++++ T Consensus 132 ~~~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~ 209 (332) T 5BQ3_A 132 VESKQVAITMLDMVSDQIGGSGKVAILSATANAANQNAWIKFMEDEIASNDKYKGIEIVAKVYGD--DDDTKSFQEAQGL 209 (332) T ss_dssp SCHHHHHHHHHHHHHHHHTSCEEEEEEESCTTCHHHHHHHHHHHHHHHHCTTSTTEEEEEEEECT--TCHHHHHHHHHHH T ss_pred cCHHHHHHHHHHHHHHHhCCCeEEEEEECCCCCHHHHHHHHHHHHHHHhchhcCCeEEEEEEeCC--CCHHHHHHHHHHH Confidence 44555566777776554 5678999985 333455666777766642 1123332111111 1112233445555 Q NP_000836.2 270 LET-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 270 ~~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++. .+.++|+... +..+..+++++++.|+..++.+++. T Consensus 210 l~~~~~~~~i~~~~-~~~a~~~~~~l~~~g~~~~v~vi~~ 248 (332) T 5BQ3_A 210 LQAHPDLNAIVSPT-TVGIAATARYLSTSDYKGKVFLTGL 248 (332) T ss_dssp HHHCTTCCEEEECS-HHHHHHHHHHHHHSTTTTTSEEEEB T ss_pred HHHCCCcCEEEeCC-cchHHHHHHHHhhcCCCCcEEEEEe Confidence 421 2455665543 4445567778877776323444443 No 272 >4RY0_A Probable ribose ABC transporter, substrate-binding; SUGAR TRANSPORTER, ENZYME FUNCTION INITIATIVE; HET: RIP; 1.4A {Rhizobium etli CFN 42} Probab=96.77 E-value=3.9e-06 Score=83.60 Aligned_cols=211 Identities=9% Similarity=0.047 Sum_probs=113.7 Template_Neff=12.000 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) +..+||++.|..+. .++.....+++.++++.+ +++.+.++..++. ...+.++++ T Consensus 2 ~~~~I~~v~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~~----~~~~~~~~l 55 (289) T 4RY0_A 2 MADLIAIITPAHDN------------PFFKAEAVGAEAKAKELG----------YETLVMTHDDDAN----KQSEMIDTA 55 (289) T ss_dssp CCCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCHH----HHHHHHHHH T ss_pred ccceEEEEecCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCHH----HHHHHHHHH Confidence 46789999987542 255667778887777642 3344444433321 222333333 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAA-ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) +. ++++++|... ...........+.+.++|+|..+...+. ..++++++.+++... T Consensus 56 ~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~d~~~~ 111 (289) T 4RY0_A 56 IG-------------------RGAKAIILDNAGADASVAAVKKAKDAGIPSFLIDREINA-----TGVAVAQIVSNNYQG 111 (289) T ss_dssp HH-------------------TTCSEEEECCSCTTTHHHHHHHHHHTTCCEEEESSCCSC-----SSSSSEEEEECHHHH T ss_pred Hh-------------------cCCCEEEEeCCChhhhHHHHHHHHHCCCCEEEeCCCCCC-----CCCceEEEEcCcHHH Confidence 32 4677665433 2222223345566789999987654331 123456677777777 Q NP_000836.2 203 AQAMVDIVTALGWN--YVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 203 ~~~~~~~l~~~~~~--~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) ++.+++++.+.+.+ +++++.. +..+...+.++|++.+++.+...+....... .+..+....+++++. ..++|+ T Consensus 112 ~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~d~ 189 (289) T 4RY0_A 112 AQLGAQEFVKLMGEKGNYVELVGKESDTNAGIRSQGYHDVIDDYPEMKSVAKQSAN--WSQTEAYSKMETILQANPDIKG 189 (289) T ss_dssp HHHHHHHHHHHHTTCEEEEEEECCTTSHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHCTTCCE T ss_pred HHHHHHHHHHHhCCCccEEEEEcCCCChhHHHHHHHHHHHHHHCCCeEEEEeeeCC--CCHHHHHHHHHHHHHHCCCCCE Confidence 77888877654433 3555543 2334556777888877664212221111000 111223344555542 135777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) |++.. +..+..+++++++.|.. ++.+++. T Consensus 190 i~~~~-~~~a~~~~~a~~~~~~~-~~~ii~~ 218 (289) T 4RY0_A 190 VISGN-DTMAMGAIAALQAAGRK-DVIVVGF 218 (289) T ss_dssp EEESS-HHHHHHHHHHHHHTTCT-TSEEECS T ss_pred EEECC-hHHHHHHHHHHHHCCCC-CeEEEEe Confidence 76664 44566777888777662 3344443 No 273 >3TB6_A Arabinose metabolism transcriptional repressor; transcription regulation, arabinose binding, DNA; HET: ARB, GOL; 2.21A {Bacillus subtilis} Probab=96.75 E-value=4.4e-06 Score=83.69 Aligned_cols=206 Identities=12% Similarity=0.113 Sum_probs=114.5 Template_Neff=12.000 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...+..+||++.|..+. .++..+..+++.++++.| +++.+.+...++ +...+.+ T Consensus 11 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~----~~~~~~~ 64 (298) T 3TB6_A 11 ALHSNKTIGVLTTYISD------------YIFPSIIRGIESYLSEQG----------YSMLLTSTNNNP----DNERRGL 64 (298) T ss_dssp ----CCEEEEEESCSSS------------TTHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHH T ss_pred hccCCCeEEEEecCCcc------------hhHHHHHHHHHHHHHHcC----------CcEEEEecCCCH----HHHHHHH Confidence 45568899999997542 256677888888887753 233444443332 2223334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI----MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~----~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) ++++. ++++++|+...+.... .....+...++|+|..+...+ .+..+++. T Consensus 65 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~ 118 (298) T 3TB6_A 65 ENLLS-------------------QHIDGLIVEPTKSALQTPNIGYYLNLEKNGIPFAMINASYA-------ELAAPSFT 118 (298) T ss_dssp HHHHH-------------------TCCSEEEECCSSTTSCCTTHHHHHHHHHTTCCEEEESSCCT-------TCSSCEEE T ss_pred HHHHh-------------------CCCCEEEEecCCcccCCCChHHHHHHHHcCCCEEEEecCCC-------CCCCCEEE Confidence 44332 4788888654433211 222355678999998776443 13456667 Q NP_000836.2 197 PPDSYQAQAMVDIVTALGWNYVSTLAS-EGNYGESGVEAFTQISREIGGVCIAQS--QKIPREPRPGEFEKIIKRLLE-- 271 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~~~~~~v~ii~~-~~~~~~~~~~~~~~~~~~~~~i~v~~~--~~~~~~~~~~~~~~~~~~l~~-- 271 (908) .+....++.+++++.+.+.++++++.. ++..+..+.++|++.+++. ++..... .......+..+..+.++++++ T Consensus 119 ~d~~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~ 197 (298) T 3TB6_A 119 LDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKRMNGFIQAHRER-ELFPSPDMIVTFTTEEKESKLLEKVKATLEKN 197 (298) T ss_dssp ECHHHHHHHHHHHHHHTTCCSEEEEEESSSHHHHHHHHHHHHHHHHT-TCCCCGGGEEEECHHHHTTHHHHHHHHHHHHT T ss_pred eCHHHHHHHHHHHHHHCCCCeEEEEEcCCCccchHHHHHHHHHHHhC-CCCCChhhEEEecchHHHHHHHHHHHHHHHHc Confidence 777777778888876667888888874 3345566777888877764 2322111 001100111111222333321 Q NP_000836.2 272 -TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 -~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ..++++|++.. +..+..+++++++.|+. T Consensus 198 ~~~~~~~i~~~~-~~~a~~~~~~l~~~g~~ 226 (298) T 3TB6_A 198 SKHMPTAILCYN-DEIALKVIDMLREMDLK 226 (298) T ss_dssp TTSCCSEEECSS-HHHHHHHHHHHHHTTCC T ss_pred ccCCCCEEEEcC-hHHHHHHHHHHHHCCCC Confidence 12478887764 44566778888877763 No 274 >3GYB_A Transcriptional regulators (LACI-FAMILY TRANSCRIPTIONAL REGULATORY; Transcription, Protein Structure Initiative II(PSI; 1.6A {Corynebacterium glutamicum} Probab=96.70 E-value=5.4e-06 Score=82.18 Aligned_cols=198 Identities=14% Similarity=0.080 Sum_probs=111.6 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||++.|..+. .++..+..+++.++++. |+++ .+.+...+ . ...+.+++ T Consensus 3 ~~~~~I~~v~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~~--~~~~~~~~-~----~~~~~~~~ 55 (280) T 3GYB_A 3 LRTQLIAVLIDDYSN------------PWFIDLIQSLSDVLTPK--------GYRL--SVIDSLTS-Q----AGTDPITS 55 (280) T ss_dssp -CCCEEEEEESCTTS------------GGGHHHHHHHHHHHGGG--------TCEE--EEECSSSS-C----SSSCHHHH T ss_pred CCCcEEEEEecCCCC------------hHHHHHHHHHHHHHHHh--------CcEE--EEEecCCC-c----ccchHHHH Confidence 457899999987542 25566777888777664 2333 33333222 1 12223333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. +++|++|+....... .+...++|++..+...+. .+..+.+.+++... T Consensus 56 ~~~-------------------~~~d~ii~~~~~~~~-----~~~~~~~pvv~~~~~~~~------~~~~~~v~~d~~~~ 105 (280) T 3GYB_A 56 ALS-------------------MRPDGIIIAQDIPDF-----TVPDSLPPFVIAGTRITQ------ASTHDSVANDDFRG 105 (280) T ss_dssp HHT-------------------TCCSEEEEESCC-------------CCCEEEESCCCSS------SCSTTEEEECHHHH T ss_pred HHh-------------------cCCCEEEEeCCCCCC-----CCcccCCCEEEeCCCCCC------CCCCcEEEeChHHH Confidence 332 478888875433321 134568998876653321 13456677777777 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAVIMF 281 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~viv~~ 281 (908) ++.+++++.+.+.++++++..+......+.++|.+.+++. ++.+....... ..+..+....+++++.. .++++|++. T Consensus 106 ~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~-~~~~~~~~~~~~~~l~~~~~~~~i~~~ 183 (280) T 3GYB_A 106 AEIATKHLIDLGHTHIAHLRVGSGAGLRRFESFEATMRAH-GLEPLSNDYLG-PAVEHAGYTETLALLKEHPEVTAIFSS 183 (280) T ss_dssp HHHHHHHHHHTTCCSEEEECCSSHHHHHHHHHHHHHHHHT-TCCCEECCCCS-CCCHHHHHHHHHHHHHHCTTCCEEEES T ss_pred HHHHHHHHHHCCCCeEEEEeCCCcchHHHHHHHHHHHHHC-CCCCCcccccC-CcccchHHHHHHHHHHhCCCCCEEEEC Confidence 8888888876677899998865556667778888887765 34433221111 01112233444455421 246777766 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~ 300 (908) . +..+..+++++++.|+. T Consensus 184 ~-~~~a~~~~~~~~~~g~~ 201 (280) T 3GYB_A 184 N-DITAIGALGAARELGLR 201 (280) T ss_dssp S-HHHHHHHHHHHHHHTCC T ss_pred C-HHHHHHHHHHHHHcCCC Confidence 4 34566778888877764 No 275 >3GYB_B Transcriptional regulators (LACI-FAMILY TRANSCRIPTIONAL REGULATORY; Transcription, Protein Structure Initiative II(PSI; HET: MSE; 1.6A {Corynebacterium glutamicum} Probab=96.70 E-value=5.4e-06 Score=82.18 Aligned_cols=198 Identities=14% Similarity=0.080 Sum_probs=106.1 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||++.|..+. .++..+..+++.++++. |+++ .+.+...+ . ...+.+++ T Consensus 3 ~~~~~I~~v~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~~--~~~~~~~~-~----~~~~~~~~ 55 (280) T 3GYB_B 3 LRTQLIAVLIDDYSN------------PWFIDLIQSLSDVLTPK--------GYRL--SVIDSLTS-Q----AGTDPITS 55 (280) T ss_dssp --CCEEEEEESCTTS------------GGGHHHHHHHHHHHGGG--------TCEE--EEECSSSS-C----SSSCHHHH T ss_pred CCCcEEEEEecCCCC------------hHHHHHHHHHHHHHHHh--------CcEE--EEEecCCC-c----ccchHHHH Confidence 457899999987542 25566777888777664 2333 33333222 1 12223333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. +++|++|+....... .+...++|++..+...+. .+..+.+.+++... T Consensus 56 ~~~-------------------~~~d~ii~~~~~~~~-----~~~~~~~pvv~~~~~~~~------~~~~~~v~~d~~~~ 105 (280) T 3GYB_B 56 ALS-------------------MRPDGIIIAQDIPDF-----TVPDSLPPFVIAGTRITQ------ASTHDSVANDDFRG 105 (280) T ss_dssp HHT-------------------TCCSEEEEECSSSSS-----CCCBCCC---------------------CCCEECHHHH T ss_pred HHh-------------------cCCCEEEEeCCCCCC-----CCcccCCCEEEeCCCCCC------CCCCcEEEeChHHH Confidence 332 478888875433321 134568998876653321 13456677777777 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAVIMF 281 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~viv~~ 281 (908) ++.+++++.+.+.++++++..+......+.++|.+.+++. ++.+....... ..+..+....+++++.. .++++|++. T Consensus 106 ~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~-~~~~~~~~~~~~~~l~~~~~~~~i~~~ 183 (280) T 3GYB_B 106 AEIATKHLIDLGHTHIAHLRVGSGAGLRRFESFEATMRAH-GLEPLSNDYLG-PAVEHAGYTETLALLKEHPEVTAIFSS 183 (280) T ss_dssp HHHHHHHHHHTTCCSEEEECCSSHHHHHHHHHHHHHHHHT-TCCCEECCCCS-CCCHHHHHHHHHHHHHHCTTCCEEEES T ss_pred HHHHHHHHHHCCCCeEEEEeCCCcchHHHHHHHHHHHHHC-CCCCCcccccC-CcccchHHHHHHHHHHhCCCCCEEEEC Confidence 8888888876677899998865556667778888887765 34433221111 01112233444455421 246777766 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~ 300 (908) . +..+..+++++++.|+. T Consensus 184 ~-~~~a~~~~~~~~~~g~~ 201 (280) T 3GYB_B 184 N-DITAIGALGAARELGLR 201 (280) T ss_dssp S-HHHHHHHHHHHHHHTCC T ss_pred C-HHHHHHHHHHHHHcCCC Confidence 4 34566778888877764 No 276 >5UFH_A LacI-type transcriptional regulator; Human Microbiome, structural genomics, PSI-Biology; HET: NO3, MSE; 1.45A {Bifidobacterium animalis subsp. lactis (strain AD011)} Probab=96.67 E-value=5.9e-06 Score=85.04 Aligned_cols=202 Identities=10% Similarity=0.039 Sum_probs=112.8 Template_Neff=11.300 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) ....+||++.|..+. .++..+..+++.++++.+ +.+. +.+...++ ....+.++. T Consensus 63 ~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~--~~~~~~~~----~~~~~~~~~ 116 (347) T 5UFH_A 63 GTTGLLGLAIFDFSQ------------PFASYLADQIIVCAREHH--------YGVI--INTYGQNE----HGLARAMRQ 116 (347) T ss_dssp ---CEEEEEESCSSS------------HHHHHHHHHHHHHHHHTT--------CEEE--EEECTTST----THHHHHHHH T ss_pred CCCCeEEEEEcCCCC------------hhHHHHHHHHHHHHHHCC--------CEEE--EEcCCCCh----HHHHHHHHH Confidence 467889999986432 245567777777776642 2333 33332221 122233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++|++|+...... .....+...++|+|..+...+ ......+..++... T Consensus 117 ~~~-------------------~~~d~ii~~~~~~~--~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~~ 168 (347) T 5UFH_A 117 ANN-------------------LAADGWIVFADHAM--GQHSKMLDQSYPLVLTGDWDA-------YGKVDQVTMPNVEA 168 (347) T ss_dssp GGG-------------------SSCSEEEEECCSCC--CC--CTTCCSSCEEEESSSCC-------TTSSEEEECCHHHH T ss_pred HHh-------------------cCCCEEEEEccccc--chhHHHHhcCCCEEEeCCccc-------CCCCcEEEcCHHHH Confidence 332 47888876544322 223445567999997765432 13455666777777 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGN------------YGESGVEAFTQISREIGGVCIAQSQKIPRE-PRPGEFEKIIKRL 269 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~------------~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~-~~~~~~~~~~~~l 269 (908) ++.+++++.+.+.++++++..+.. +...+.++|++.+++. ++.+.....+... .+..+....++++ T Consensus 169 ~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~ 247 (347) T 5UFH_A 169 MRYTTNRLLDSGYRSIALFGADGSLGARHYRQATEGTQELRVQGYMQAYEEH-GIEARMDMLFSGGLLTSDSGVRATNLM 247 (347) T ss_dssp HHHHHHHHHHTTCCCEEEESSCGGGCHHHHHHCCSCHHHHHHHHHHHHHHHT-TCCCCGGGEECCSSSSHHHHHHHHHHH T ss_pred HHHHHHHHHHcCCCeEEEEcCCcccchhhhhccCcccHHHHHHHHHHHHHHC-CCCCCHHHeecCCCCChHHHHHHHHHH Confidence 888888886678889999985432 4456778888888775 3443221111100 1111223344444 Q NP_000836.2 270 LE-TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 270 ~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +. ..++|+|++.. +..+..+++++++.|+. T Consensus 248 ~~~~~~~~ai~~~~-d~~a~~~~~~l~~~g~~ 278 (347) T 5UFH_A 248 MDQGVRPDAIICLN-DAMALGALHQLQVRGIR 278 (347) T ss_dssp HHTTCCCSEEEESS-HHHHHHHHHHHHHTTCC T ss_pred HHcCCCCCEEEECC-HHHHHHHHHHHHHCCCC Confidence 32 13678887764 44567778888887764 No 277 >3CTP_A Periplasmic binding protein/LacI transcriptional regulator; STRUCTURAL GENOMICS, PROTEIN STRUCTURE INITIATIVE; HET: XLF; 1.41A {Alkaliphilus metalliredigens} Probab=96.67 E-value=6e-06 Score=84.26 Aligned_cols=198 Identities=13% Similarity=0.148 Sum_probs=114.7 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+..+||++.|..+. .++..+..+++.++++.+ +++.+.+...+. ....+.++ T Consensus 57 ~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 110 (330) T 3CTP_A 57 TKNSKTIGLMVPNISN------------PFFNQMASVIEEYAKNKG----------YTLFLCNTDDDK----EKEKTYLE 110 (330) T ss_dssp ---CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHHH T ss_pred cCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHCC----------CEEEEEeCCCCH----HHHHHHHH Confidence 3567899999986432 245567777777776642 234444543332 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+.. ..+...++|+|..+...+ +..+++..++.. T Consensus 111 ~~~~-------------------~~~d~ii~~~~~~~-----~~~~~~~ipvv~~~~~~~--------~~~~~v~~d~~~ 158 (330) T 3CTP_A 111 VLQS-------------------HRVAGIIASRSQCE-----DEYANIDIPVVAFENHIL--------DNIITISSDNYN 158 (330) T ss_dssp HHHH-------------------TTCSEEEEETCCCS-----GGGTTCCSCEEEESSCCC--------TTSCEEEECHHH T ss_pred HHHH-------------------CCCCEEEEeCCCCh-----HHHhcCCCCEEEEcCCCc--------cCCcEEEcCcHH Confidence 3332 47888886543322 235667999998765432 245667777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) .+..+++++.+.++++++++..+. .+...+.+++++.+++. ++.+.... ...+.+..+....++.+....++|+|+ T Consensus 159 ~g~~~~~~l~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~i~ 236 (330) T 3CTP_A 159 GGRMAFDHLYEKGCRKILHIKGPEVFEATELRYKGFLDGARAK-DLEIDFIE-FQHDFQVKMLEEDINSMKDIVNYDGIF 236 (330) T ss_dssp HHHHHHHHHHHTTCCSEEEEECCTTCHHHHHHHHHHHHHHHHT-TCCCEEEE-CSSSCCGGGGGCCCTTGGGGGGSSEEE T ss_pred HHHHHHHHHHHcCCCcEEEEeCCccchhHHHHHHHHHHHHHHC-CCCCCeEE-ecccccHHHHHHHHHHhhhcCCCCEEE Confidence 788888888777888999988543 35566778888887764 34432211 110011122333444443223578777 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~ 300 (908) +.. +..+..+++++++.|+. T Consensus 237 ~~~-~~~a~~~~~al~~~g~~ 256 (330) T 3CTP_A 237 VFN-DIAAATVMRALKKRGVS 256 (330) T ss_dssp ESS-HHHHHHHHHHHHHTTCC T ss_pred EcC-HHHHHHHHHHHHHCCCC Confidence 764 44566778888887763 No 278 >3G85_A Transcriptional regulator (LacI family); Transcription regulator, PSI-II, 11230o, Structural; 1.84A {Clostridium acetobutylicum ATCC 824} Probab=96.67 E-value=6e-06 Score=82.30 Aligned_cols=204 Identities=12% Similarity=0.083 Sum_probs=115.0 Template_Neff=11.700 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++..+||++.|.... ..++.....+++.++++.+ +.+++.+.+...+... ... T Consensus 7 ~~~~~~~I~~i~~~~~~-----------~~~~~~~~~g~~~a~~~~g--------~~~~~~~~~~~~~~~~----~~~-- 61 (289) T 3G85_A 7 NSQSKPTIALYWSSDIS-----------VNIISRFLRGLQSKLAKQN--------YNYNVVICPYKTDCLH----LEK-- 61 (289) T ss_dssp ----CCEEEEEEETTSC-----------GGGHHHHHHHHHHHHHHTT--------TCSEEEEEEECTTCGG----GCG-- T ss_pred cCCCCCeEEEEeCCCCC-----------cHHHHHHHHHHHHHHHHcC--------CCcEEEEEEcCCChHH----Hhh-- Confidence 45578999999983211 1356677888888887752 2345555554433211 111 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +.+.. .++|++|+...+......... ...++|+|..+... +.+..+..++. T Consensus 62 ~~~~~-------------------~~~d~ii~~~~~~~~~~~~~~-~~~~ipvv~~~~~~---------~~~~~v~~d~~ 112 (289) T 3G85_A 62 GISKE-------------------NSFDAAIIANISNYDLEYLNK-ASLTLPIILFNRLS---------NKYSSVNVDNY 112 (289) T ss_dssp GGSTT-------------------TCCSEEEESSCCHHHHHHHHH-CCCSSCEEEESCCC---------SSSEEEEECHH T ss_pred chhhh-------------------cCCCEEEEecCCcccHHHHHH-hCCCCCEEEeCCCc---------cCCCEEEeCcH Confidence 01111 578888865443322223333 46789999877532 23456667777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) ..++.+++++.+.+.++++++..+. .....+.++|++.+++. ++.+..........+..+..+.+++++. ..++++ T Consensus 113 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~l~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ 191 (289) T 3G85_A 113 KMGEKASLLFAKKRYKSAAAILTESLNDAMDNRNKGFIETCHKN-GIKISENHIIAAENSIHGGVDAAKKLMKLKNTPKA 191 (289) T ss_dssp HHHHHHHHHHHHTTCCBCEEEECCCSSHHHHHHHHHHHHHHHHT-TCBCCGGGEEECCSSHHHHHHHHHHHTTSSSCCSE T ss_pred HHHHHHHHHHHHcCCCeeEEEecCCCChHHHHHHHHHHHHHHHc-CCCCCccceEEcCCChHHHHHHHHHHHhcCCCCCE Confidence 7788888888777888998887432 34566778888888765 3443321111100111223344455432 135777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 192 i~~~~-~~~a~~~~~~l~~~g~~ 213 (289) T 3G85_A 192 LFCNS-DSIALGVISVLNKRQIS 213 (289) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 77664 44566778888877764 No 279 >3H5O_B Transcriptional regulator GntR; 11234b, transcription regulator, GntR, Chromobacterium; HET: MSE, SO4; 2.3A {Chromobacterium violaceum} Probab=96.67 E-value=6.1e-06 Score=84.58 Aligned_cols=203 Identities=14% Similarity=0.107 Sum_probs=113.6 Template_Neff=11.300 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+..+||++.|..+. .++.....+++.++++.+ +++.+.|+..++ +...+.++ T Consensus 59 ~~~~~~I~~v~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 112 (339) T 3H5O_B 59 SAKSRTVLVLIPSLAN------------TVFLETLTGIETVLDAAG----------YQMLIGNSHYDA----GQELQLLR 112 (339) T ss_dssp ----CEEEEEESCSTT------------CTTHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHHH T ss_pred cCCCCEEEEEEcCCCC------------hhHHHHHHHHHHHHHHcC----------CeEEEEeCCCCh----hHHHHHHH Confidence 3567899999986542 245567778877776643 233444543332 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+.. ......+...++|+|..+...+ +.++.+..++.. T Consensus 113 ~l~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~--------~~~~~v~~d~~~ 164 (339) T 3H5O_B 113 AYLQ-------------------HRPDGVLITGLSHA-EPFERILSQHALPVVYMMDLAD--------DGRCCVGFSQED 164 (339) T ss_dssp HHHT-------------------TCCSEEEEESSCCC-TTHHHHHHHTTCCEEEEESCCS--------SSCCEEECCHHH T ss_pred HHHh-------------------cCCCEEEEeCCCCC-hHHHHHHHhCCCCEEEEccCCC--------CCCcEEEcCHHH Confidence 4332 46888886543332 3344556678999998764321 345566677777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPR-EPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~-~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .++.+++++.+.+.++++++... +.....+.++|++.+++. +..+........ ..+.......+++++. ..++|+| T Consensus 165 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~r~~~~~~~l~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~d~I 243 (339) T 3H5O_B 165 AGAAITRHLLSRGKRRIGFLGAQLDERVMKRLDGYRAALDAA-DCRDAGLEWLDPQPSSMQMGADMLDRALAERPDCDAL 243 (339) T ss_dssp HHHHHHHHHHHTTCCSEEEEEESCCHHHHHHHHHHHHHHHHH-TCCCGGGEEEECSCCCHHHHHHHHHHHHHHCTTCCEE T ss_pred HHHHHHHHHHHCCCCcEEEEeCCCCHHHHHHHHHHHHHHHHC-CCcccCCccccCCCCCHHHHHHHHHHHHHhCCCCCEE Confidence 78888888876688899999854 334556777888877764 232211111110 0011112233333332 1356777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 244 ~~~~-~~~a~~~~~~l~~~g~~ 264 (339) T 3H5O_B 244 FCCN-DDLAIGALARSQQLGIA 264 (339) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHcCCC Confidence 7664 44566778888877763 No 280 >5YSZ_A Transcriptional regulator, LacI family; transcriptional regulator, cellulase gene regulator; HET: CBI, GOL; 1.631A {Thermobifida fusca YX} Probab=96.62 E-value=7.5e-06 Score=84.75 Aligned_cols=148 Identities=11% Similarity=0.080 Sum_probs=89.0 Template_Neff=11.100 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++|++|+...+... .....+...++|+|..+...+. ..+.++.+..++...+..+++++.+.+.++++++..+ T Consensus 143 ~~~d~ii~~~~~~~~-~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~d~~~~~~~~~~~l~~~g~~~i~~l~~~ 216 (360) T 5YSZ_A 143 QHVDGVLLLSLHRDD-PLPQMLDEAGVPYVYGGRPLGV-----PEEQVSYVDIDNIGGGRQATQRLIETGHRRIATIAGP 216 (360) T ss_dssp SCCSEEEEESCCTTC-SHHHHHHHHTCCEEEESCCTTS-----CGGGCCEEEECHHHHHHHHHHHHHHTTCSSEEEEECC T ss_pred CCCCEEEEECCCCCC-chHHHHHHcCCCEEEeCCCCCC-----CcccCcEEEcCcHHHHHHHHHHHHHcCCCcEEEEeCC Confidence 578888765433332 3445566789999987754321 1245667777777788888888876788899999854 Q NP_000836.2 225 GN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 225 ~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) .. +...+.++|++.+++. ++.+........+.+..+....++++++ ..++|+|++.. +..+..+++++++.|.. T Consensus 217 ~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~daI~~~~-d~~a~~~~~al~~~g~~ 293 (360) T 5YSZ_A 217 QDMVAGVERLQGYREALLAA-GMEYDETLVSYGDFTYDSGVAAMRELLDRAPDVDAVFAAS-DLMGLAALRVLRASGRR 293 (360) T ss_dssp TTSHHHHHHHHHHHHHHHHT-TCCCCGGGEEECCSSHHHHHHHHHHHHHHCTTCCEEEESS-HHHHHHHHHHHHHTTCC T ss_pred cccHHHHHHHHHHHHHHHHC-CCCCCHhheeecCCCHHHHHHHHHHHHHhCCCCCEEEECC-hHHHHHHHHHHHHcCCC Confidence 33 5566778888887765 3433211111100112233444555542 12477777664 44566778888877763 No 281 >3MIZ_A Putative transcriptional regulator protein, LacI; Lacl family, Protein Structure Initiative; HET: MSE; 1.91A {Rhizobium etli} Probab=96.58 E-value=8.6e-06 Score=81.66 Aligned_cols=206 Identities=13% Similarity=0.104 Sum_probs=115.6 Template_Neff=11.800 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...+..+||++.|..... .+...+..+++.++++.+ +++.+.+...++ +...+.+ T Consensus 9 ~~~~~~~I~~v~~~~~~~-----------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~ 63 (301) T 3MIZ_A 9 RSSRSNTFGIITDYVSTT-----------PYSVDIVRGIQDWANANG----------KTILIANTGGSS----EREVEIW 63 (301) T ss_dssp ---CCCEEEEEESSTTTC-----------CSCHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHH T ss_pred hcCCCCEEEEEecCCCCC-----------chHHHHHHHHHHHHHHcC----------CeEEEEecCCCH----HHHHHHH Confidence 456789999999854211 245567778777776642 233444443332 2223334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. +++|++|+....... ....+...++|+|..+...+. .+.++.+..++. T Consensus 64 ~~~~~-------------------~~~d~ii~~~~~~~~--~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 116 (301) T 3MIZ_A 64 KMFQS-------------------HRIDGVLYVTMYRRI--VDPESGDVSIPTVMINCRPQT------RELLPSIEPDDY 116 (301) T ss_dssp HHHHH-------------------TTCSEEEEEEEEEEE--CCCCCTTCCCCEEEEEEECSS------TTSSCEEEECHH T ss_pred HHHHh-------------------CCCCEEEEecCCccc--CCcccccCCCCEEEEcCCCCC------cccCCcceeChH Confidence 43332 478888865433221 222456789999987764321 234567777777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPR-----EPRPGEFEKIIKRLLET- 272 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~-----~~~~~~~~~~~~~l~~~- 272 (908) ..++.+++++.+.+.++++++..+. .....+.+++++.+++. ++.+.....+.. ..+..+....++++++. T Consensus 117 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~ 195 (301) T 3MIZ_A 117 QGARDLTRYLLERGHRRIGYIRLNPILLGAELRLDAFRRTTSEF-GLTENDLSISLGMDGPVGAENNYVFAAATEMLKQD 195 (301) T ss_dssp HHHHHHHHHHHTTTCCSEEEEECCTTSHHHHHHHHHHHHHHHHH-TCCGGGEEEEECEESSTTSCEECHHHHHHHHHTST T ss_pred HHHHHHHHHHHHCCCCcEEEEecCcccccHHHHHHHHHHHHHHc-CCChhhceEEecCCCCCCcccchHHHHHHHHHhcC Confidence 7888888888666788999988533 23456777888887765 344321111100 00111122344554421 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) .++++|++.. +..+..+++++++.|+. T Consensus 196 ~~~~~i~~~~-~~~a~~~~~~l~~~g~~ 222 (301) T 3MIZ_A 196 DRPTAIMSGN-DEMAIQIYIAAMALGLR 222 (301) T ss_dssp TCCSEEEESS-HHHHHHHHHHHHTTTCC T ss_pred CCCCEEEECC-HHHHHHHHHHHHHCCCC Confidence 2477777664 44566777777777763 No 282 >1TJY_A sugar transport protein; PROTEIN-LIGAND COMPLEX, SIGNALING PROTEIN; HET: PAV; 1.3A {Salmonella typhimurium} SCOP: c.93.1.1 Probab=96.56 E-value=9.4e-06 Score=82.17 Aligned_cols=210 Identities=10% Similarity=-0.009 Sum_probs=113.6 Template_Neff=11.200 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDT-CSRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~-~~~~~~a~~~~~~~~~~ 122 (908) ++++||++.|..+. .++.....+++.++++.+ +++. +.+. ..+. ....+.+++ T Consensus 2 ~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~--~~~~~~~~~----~~~~~~~~~ 55 (316) T 1TJY_A 2 SAERIAFIPKLVGV------------GFFTSGGNGAQEAGKALG--------IDVT--YDGPTEPSV----SGQVQLVNN 55 (316) T ss_dssp CCCEEEEECSSSSS------------HHHHHHHHHHHHHHHHHT--------CEEE--ECCCSSCCH----HHHHHHHHH T ss_pred CCeEEEEEecCCCC------------HHHHHHHHHHHHHHHHhC--------CEEE--EECCCCCCH----HHHHHHHHH Confidence 46789999987542 255677788888877752 3333 3333 2222 223334444 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAAS-SVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP-PDS 200 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s-~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~-~~~ 200 (908) ++. .+++++++...+ .........+...++|+|......+. .+..+.+.. ++. T Consensus 56 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~~d~~ 110 (316) T 1TJY_A 56 FVN-------------------QGYDAIIVSAVSPDGLCPALKRAMQRGVKILTWDSDTKP------ECRSYYINQGTPK 110 (316) T ss_dssp HHH-------------------TTCSEEEECCSSSSTTHHHHHHHHHTTCEEEEESSCCCG------GGCSEEEESCCHH T ss_pred HHH-------------------cCCCEEEEcCCChhhhHHHHHHHHHCCCEEEEECCCCCc------hhceeEEecCCHH Confidence 332 467877764333 22234455667789999987764331 122334444 455 Q NP_000836.2 201 YQAQAMVDIVTAL-G--WNYVSTLAS--EGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLET-P 273 (908) Q Consensus 201 ~~~~~~~~~l~~~-~--~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~ 273 (908) ..++.+++++.+. + .++|+++.. ++.....+.++|++.+++.. ++.+....... .+..+....+++++.. . T Consensus 111 ~~g~~~~~~l~~~~~~~~~~v~~l~~~~~~~~~~~r~~g~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~ 188 (316) T 1TJY_A 111 QLGSMLVEMAAHQVDKEKAKVAFFYSSPTVTDQNQWVKEAKAKISQEHPGWEIVTTQFGY--NDATKSLQTAEGIIKAYP 188 (316) T ss_dssp HHHHHHHHHHHHHHCSSSEEEEEEESCSSCHHHHHHHHHHHHHHHHHCTTEEEEEEEECT--TCHHHHHHHHHHHHHHCS T ss_pred HHHHHHHHHHHHHhCCCCCeEEEEECCCCcHHHHHHHHHHHHHHHHHCCCcEEEeeccCC--CCHHHHHHHHHHHHHHCC Confidence 6677777777543 5 678998875 33455667778888776531 23333211111 1112233445555421 2 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++++|+... +..+..+++++++.|+. ++.+++. T Consensus 189 ~~~~i~~~~-~~~a~~~~~al~~~g~~-~v~v~g~ 221 (316) T 1TJY_A 189 DLDAIIAPD-ANALPAAAQAAENLKRN-NLAIVGF 221 (316) T ss_dssp SCCEEEECS-TTHHHHHHHHHHHTTCC-SCEEEEB T ss_pred CCCEEEecC-CCchHHHHHHHHHcCCC-CcEEEEe Confidence 456665543 44556677787777762 3334443 No 283 >4O5A_A LacI family transcription regulator; structural genomics, PSI-Biology, protein structure; HET: SO4, GOL; 1.777A {Bifidobacterium animalis subsp. lactis} Probab=96.55 E-value=9.7e-06 Score=83.19 Aligned_cols=207 Identities=12% Similarity=0.108 Sum_probs=115.3 Template_Neff=11.600 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+..+||++.|.++.... ...++..+..+++.++++.+ + ++.+.+...+. ...+.+. T Consensus 65 ~~~~~~Igvv~~~~~~~~~-------~~~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~-----~~~~~~~ 122 (345) T 4O5A_A 65 QSRTRRIGLVLGYDPQLLS-------AEPYIMRLISGLGSALEERD--------Y--SLLVRMSMDDD-----DEVSILE 122 (345) T ss_dssp -CCCCEEEEEEECC---------------CHHHHHHHHHHHHGGGT--------C--EEEEEEECSSS-----HHHHHHH T ss_pred cCCCCEEEEEEeCChHHhc-------cChHHHHHHHHHHHHHHHCC--------C--EEEEEecCCCc-----cHHHHHH Confidence 4567899999987531000 01245567777777776542 2 23333332221 1112222 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. ..++|++|+...+.....+..+....++|+|..+...+ .+.++++.+++.. T Consensus 123 ~~~~------------------~~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 177 (345) T 4O5A_A 123 DWIA------------------TGNVDALLLLNLEIGDPRIELMKNNPQMPCLALADSSL-------TSGLPTLMSDDAA 177 (345) T ss_dssp HHHH------------------HTCSSEEEECSCCTTCHHHHHHHTCTTSCEEEEECGGG-------TTTSCEEECCHHH T ss_pred HHHH------------------hCCCCEEEEeCCcCCChHHHHHHhCCCCCEEEEccccc-------CCCCCEEEeCcHH Confidence 2221 15788888755443332222333357999988765432 1345667777778 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .+..+++++.+.+.++++++..... ....+.++|.+.+++. ++.+.. .... .+..+....+++++. ..++|+| T Consensus 178 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~l~~~-~~~~~~-~~~~--~~~~~~~~~~~~~l~~~~~~dai 253 (345) T 4O5A_A 178 ASGTMIRHLALFGHKNIARVAGPEELGHSYIRDAAFSEITTEL-GMRYRC-LHTD--YTPESGAEATKRLLSVEPRPTAI 253 (345) T ss_dssp HHHHHHHHHHHTTCCEEEEEECCTTSTTHHHHHHHHHHHHHHT-TCEEEE-EECC--SCHHHHHHHHHHHHHSSSCCSEE T ss_pred HHHHHHHHHHHcCCCeEEEEeCchhccchHHHHHHHHHHHHHh-CCceEE-EecC--CCHHHHHHHHHHHhcCCCCCCEE Confidence 8888888887778889999985332 4556778888888765 344321 1111 111223344455432 2367888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 254 ~~~~-d~~a~~~~~~l~~~g~~ 274 (345) T 4O5A_A 254 IYDN-DVMALAGESVASVKGVR 274 (345) T ss_dssp EESS-HHHHHHHHHHHHHHTCC T ss_pred EECC-HHHHHHHHHHHHHcCCC Confidence 7764 44566788888887763 No 284 >3UUG_B Multiple sugar-binding periplasmic receptor ChvE; periplasmic binding protein, SUGAR-BINDING PROTEIN; HET: BDP; 1.75A {Agrobacterium tumefaciens} Probab=96.50 E-value=1.2e-05 Score=81.98 Aligned_cols=206 Identities=10% Similarity=0.011 Sum_probs=114.2 Template_Neff=11.400 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) +..+||++.|.... .++.....+++.++++.| + ++.+.+...+. +...+.++++ T Consensus 2 ~~~~Ig~v~~~~~~------------~~~~~~~~~~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~~~l 55 (330) T 3UUG_B 2 DKGSVGIAMPTKSS------------ARWIDDGNNIVKQLQEAG--------Y--KTDLQYADDDI----PNQLSQIENM 55 (330) T ss_dssp CCCEEEEEECCSSS------------THHHHHHHHHHHHHHHTT--------C--EEEEEECTTCH----HHHHHHHHHH T ss_pred CCceEEEEcCCCCC------------HHHHHHhhHHHHHHHHcC--------C--EEEEEecCCCH----HHHHHHHHHH Confidence 46789999987521 245567778887777653 2 33344433332 1223333433 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) +. .+++++|+...+... ......+...++|+|..+...+. ..++++++.+++... T Consensus 56 ~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~d~~~~ 111 (330) T 3UUG_B 56 VT-------------------KGVKVLVIASIDGTTLSDVLKQAGEQGIKVIAYDRLIRN-----SGDVSYYATFDNFQV 111 (330) T ss_dssp HH-------------------HTCSEEEECCSSGGGGHHHHHHHHHTTCEEEEESSCCCS-----CTTCCEEEEECHHHH T ss_pred Hh-------------------cCCCEEEEecCCccchHHHHHHHHHCCCEEEEEcCCCCC-----CCCccEEEEeChHHH Confidence 32 478887765433322 23445566789999987754331 123456677777777 Q NP_000836.2 203 AQAMVDIVTA-------LGWNYVSTLAS--EGNYGESGVEAFTQISREIGG-VCIAQSQK-------IPREPRPGEFEKI 265 (908) Q Consensus 203 ~~~~~~~l~~-------~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~-i~v~~~~~-------~~~~~~~~~~~~~ 265 (908) +..+++++.+ .+.++++++.. ++..+..+.++|++.+++.+. ..+..... .....+..+.... T Consensus 112 ~~~~~~~l~~~~~~~~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~ 191 (330) T 3UUG_B 112 GVLQATSITDKLGLKDGKGPFNIELFGGSPDDNNAFFFYDGAMSVLKPYIDSGKLVVKSGQMGMDKVGTLRWDPATAQAR 191 (330) T ss_dssp HHHHHHHHHHHHTGGGTCCCEEEEECCCCTTCHHHHHHHHHHHHHHHHHHHHTSEECTTCCCSHHHHCCGGGCHHHHHHH T ss_pred HHHHHHHHHHHhcccCCCCCcEEEEEecCCCCccHHHHHHHHHHHhHHhhhcCcEEEeeCCcccccccccCCCHHHHHHH Confidence 7777777654 46778998873 334556677788877765421 11211100 0000111223344 Q NP_000836.2 266 IKRLLET----PNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 266 ~~~l~~~----~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +++++.. .++++|++.. +..+..+++++++.|+. T Consensus 192 ~~~~l~~~~~~~~~~ai~~~~-~~~a~~~~~al~~~g~~ 229 (330) T 3UUG_B 192 MDNLLSAYYTDAKVDAVLSPY-DGLSIGIISSLKGVGYG 229 (330) T ss_dssp HHHHHHHHCSSSCCCEEECSS-HHHHHHHHHHHHHTTCS T ss_pred HHHHHHhhcCCCCccEEEeCC-cHHHHHHHHHHHhCCCC Confidence 4555421 2367776664 44566778888877764 No 285 >3LKV_A uncharacterized CONSERVED DOMAIN PROTEIN; ATPase Binding Cassette, PSI, MCSG; HET: PHE; 2.2A {Vibrio cholerae} Probab=96.46 E-value=1.3e-05 Score=80.10 Aligned_cols=215 Identities=8% Similarity=0.110 Sum_probs=114.8 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) .....++||++.|... .++.....+++.++++.+.. .|+++++.+.|+..++. ...+.+ T Consensus 4 ~~~~~~~I~~v~~~~~-------------~~~~~~~~~~~~~~~~~g~~----~g~~~~~~~~~~~~~~~----~~~~~~ 62 (302) T 3LKV_A 4 IMAKTAKVAVSQIVEH-------------PALDATRQGLLDGLKAKGYE----EGKNLEFDYKTAQGNPA----IAVQIA 62 (302) T ss_pred ccCCCeEEEEEcCCCC-------------HHHHHHHHHHHHHHHHhCCC----CCceEEEEEEcCCCCHH----HHHHHH Confidence 4456889999998642 24556667777666654321 24567776666544322 222333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSD-----NTRYDFFSRV 195 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~-----~~~~~~~~~~ 195 (908) +++.. .+++++|+.... ....... . ..++|+|......+.... .....+++.+ T Consensus 63 ~~~~~-------------------~~~d~ii~~~~~-~~~~~~~-~-~~~ipvv~~~~~~~~~~~~~~~~~~~~~~~~~~ 120 (302) T 3LKV_A 63 RQFVG-------------------ENPDVLVGIATP-TAQALVS-A-TKTIPIVFTAVTDPVGAKLVKQLEQPGKNVTGL 120 (302) T ss_pred HHHHH-------------------CCCCEEEEeCCc-hHHHHHH-H-hcCCCEEEEcCCCCCccchhhcCCCCCCcEEEc Confidence 33322 478888874322 2222222 2 679999987754432110 0012233333 Q NP_000836.2 196 VPPDSYQAQAMVDIVTAL--GWNYVSTLASEGN-YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~--~~~~v~ii~~~~~-~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) +....++.+++++.+. +.+++++++.+.. ++..+.+++++.+++. ++.+...... +..+....++++. T Consensus 121 --~~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~----~~~~~~~~~~~~~-- 191 (302) T 3LKV_A 121 --SDLSPVEQHVELIKEILPNVKSIGVVYNPGEANAVSLMELLKLSAAKH-GIKLVEATAL----KSADVQSATQAIA-- 191 (302) T ss_pred --CHHHHHHHHHHHHHHHCCCCcEEEEEeCCCChhHHHHHHHHHHHHHcC-CCeEeEeeCC----CHHHHHHHHHHHC-- Confidence 3333456667776554 7789999985443 4556677788777664 3544322111 1123444455443 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) .++++|++..+ ..+..+++++.+.+...++.+++. T Consensus 192 ~~~~~i~~~~~-~~~~~~~~~~~~~~~~~~i~i~~~ 226 (302) T 3LKV_A 192 EKSDVIYALID-NTVASAIEGMIVAANQAKTPVFGA 226 (302) T ss_pred CCCCEEEECCc-hHHHHHHHHHHHCCCCCCCcEEEe Confidence 36788876653 345556666666554323444443 No 286 >4KQC_A Periplasmic binding protein/LacI transcriptional regulator; structural genomics, APC110243, ABC transporter; HET: NO3; 1.62A {Brachyspira murdochii} Probab=96.39 E-value=1.8e-05 Score=80.11 Aligned_cols=209 Identities=12% Similarity=0.062 Sum_probs=109.7 Template_Neff=11.600 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) ++..+||++.|.... .++..+..+++.++++. |+++.+...++..+. ....+.+++ T Consensus 2 ~~~~~I~~v~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~~~~~~~~~~~~~----~~~~~~i~~ 57 (319) T 4KQC_A 2 NADPYIAVVSKGFQH------------KFWVTVRDGAEAAAKQN--------GVKISFVGPETESDS----KIQQDLLDS 57 (319) T ss_dssp CSSCEEEEECCCSSS------------THHHHHHHHHHHHHHHH--------TCEEEEECCSSTTCH----HHHHHHHHH T ss_pred CCCCeEEEEecCCCC------------HHHHHHHHHHHHHHHHc--------CCEEEEeCCCCCCCH----HHHHHHHHH Confidence 356889999984321 24566777887777764 344544433321221 123334444 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++|++|+...+.........+...++|+|..+...+... .....++.+.+++... T Consensus 58 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~--~~~~~~~~v~~d~~~~ 116 (319) T 4KQC_A 58 EIN-------------------KNPDAIAFAAVTGDFTEQIKRIKEKNIPLIGFDSGILPDQ--AQGAVLATASTDNRAA 116 (319) T ss_dssp HHH-------------------TCCSCEEECCCSSCCHHHHHHHHHTTCCEEEETTCSCGGG--CTTCEEEEEECCHHHH T ss_pred HHH-------------------hCCCEEEEcCCCcchHHHHHHHHHCCCCEEEEcCCCCccc--ccCceeEEEEcChHHH Confidence 432 4788887654433222334455678999998876433211 0123456677777777 Q NP_000836.2 203 AQAMVDIVTALGWN-----------YVSTLASE-GNYGESGVEAFTQISREIGGVCIA-------QSQKIPREPRPGEFE 263 (908) Q Consensus 203 ~~~~~~~l~~~~~~-----------~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~-------~~~~~~~~~~~~~~~ 263 (908) ++.+++++.+.+.+ +++++... +.....+.++|++.+++.+ .... .........+..+.. T Consensus 117 g~~~~~~l~~~~~~~i~~~~~~~~~~v~~~~~~~~~~~~~r~~g~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~ 195 (319) T 4KQC_A 117 AAIVADKMFEALKTRIAAFTSDNKAKIAVLQLDNSDTGIGRAEGFVKRFTELA-DGDAATAGKYALQVIVPTTQNEADIA 195 (319) T ss_dssp HHHHHHHHHHHHHHHHHTSBTTBCEEEEEECCCSSHHHHHHHHHHHHHHHHHH-HHSTTTTTSEEEEEECCSSSSHHHHH T ss_pred HHHHHHHHHHHHHHHhhhcCCCCcEEEEEEEeCCCcchHHHHHHHHHHHHhcc-CcchhhCcceeeEEEccCCCCHHHHH Confidence 88888877554443 34444422 3345566777877776642 2210 000000001111222 Q NP_000836.2 264 KIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 264 ~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) ..++.+. ..++++|++.. +..+..+++++++.|. T Consensus 196 ~~~~~l~-~~~~~~i~~~~-~~~a~~~~~a~~~~g~ 229 (319) T 4KQC_A 196 NEVNALR-GKSVLGIYLSN-EAMARGFLVVYKSAEA 229 (319) T ss_dssp HHHHTTT-TTTCSEEEECS-HHHHHHHHHHCCBCST T ss_pred HHHHHHh-cCCceEEEEcC-HHHHHHHHHHHHhccc Confidence 3333332 24667777664 4455677777777664 No 287 >4WWH_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: MSE, TRS, GAL; 1.2A {Mycobacterium smegmatis} Probab=96.38 E-value=1.8e-05 Score=81.89 Aligned_cols=210 Identities=12% Similarity=0.038 Sum_probs=113.1 Template_Neff=11.000 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+..+||++.|..+. .++.....+++.++++.| +++.+.+...+. +...+. T Consensus 30 ~~~~~~~~Igvv~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~ 83 (362) T 4WWH_A 30 GDGDAKGTVGIAMPTKSS------------ERWVADGQNMVDQFKAFG----------YDTDLQYGDDVV----QNQVSQ 83 (362) T ss_dssp ----CCCEEEEEECCSSS------------THHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHH T ss_pred ccCCCCceEEEEcCCCCC------------HHHHHHHhHHHHHHHHhC----------CeEEEeecCccH----HHHHHH Confidence 345678999999987532 234556677777776643 233344433332 122333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. .++|++|........ ......+...++|+|..+...+.. .+..+.+..+ T Consensus 84 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~-----~~~~~~v~~d 139 (362) T 4WWH_A 84 IENMIT-------------------KGVKLLVIAPIDGSSLTNTLQHAADLKIPVISYDRLIKGT-----PNVDYYATFD 139 (362) T ss_dssp HHHHHH-------------------TTCSEEEECCSSTTSCHHHHHHHHHTTCCEEEESSCCCSC-----SCCCEEEEEC T ss_pred HHHHHh-------------------cCCCEEEEecCChhhhHHHHHHHHHCCCCEEEeCCCCCCC-----CCCcEEEEec Confidence 443332 467877764433322 234455667899999877543310 1235566677 Q NP_000836.2 199 DSYQAQAMVDIVTA-------LGWNYVSTLAS--EGNYGESGVEAFTQISREIGG-VCIAQSQK-------IPREPRPGE 261 (908) Q Consensus 199 ~~~~~~~~~~~l~~-------~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~-i~v~~~~~-------~~~~~~~~~ 261 (908) +...++.+++++.+ .+.++|+++.. +......+.++|++.+++.+. ..+..... .....+..+ T Consensus 140 ~~~~g~~~~~~l~~~~~~~~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 219 (362) T 4WWH_A 140 NTKVGVLQANYIVDTLGVADGKGPFNLELFAGSPDDNNATYFFQGAMSVLQPYIDSGKLVVKSGQTTFDQIATLRWDGGL 219 (362) T ss_dssp HHHHHHHHHHHHHHHHTGGGTCCCEEEEECBCCTTCTHHHHHHHHHHHHHHHHHHHTSEECTTCCCSHHHHBCGGGCHHH T ss_pred HHHHHHHHHHHHHHHhCCcCCCCCeEEEEEECCCCChhHHHHHHHHHHHhHhhccCCeEEEeeCccccccccccCCCHHH Confidence 77777888887754 46778998874 233455667778777765421 11211100 000011122 Q NP_000836.2 262 FEKIIKRLLET----PNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 262 ~~~~~~~l~~~----~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ....+++++.. .++++|++.. +..+..+++++++.|+. T Consensus 220 ~~~~~~~~l~~~~~~~~~daii~~~-~~~a~~~~~al~~~g~~ 261 (362) T 4WWH_A 220 AQSRMDNLLSQAYTSGRVDAVLSPY-DGISRGVISALKSAGYG 261 (362) T ss_dssp HHHHHHHCCCCCCSSSCCCEEECSS-HHHHHHHHHHHHHTTCS T ss_pred HHHHHHHHHHHHhcCCCccEEEeCC-hHHHHHHHHHHHHCCCC Confidence 34445555421 2567777654 34466677788777763 No 288 >3CS3_A Sugar-binding transcriptional regulator, LacI family; STRUCTURAL GENOMICS, SUGAR-BINDING TRANSCRIPTIONAL REGULATOR; HET: SO4; 2.4A {Enterococcus faecalis} Probab=96.37 E-value=1.8e-05 Score=78.05 Aligned_cols=194 Identities=11% Similarity=0.015 Sum_probs=113.5 Template_Neff=11.600 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++..+||++.|..+. .++.....+++.++++. |+++ .+.+...+ . + T Consensus 5 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~~--~~~~~~~~--------~---~ 51 (277) T 3CS3_A 5 RRQTNIIGVYLADYGG------------SFYGELLEGIKKGLALF--------DYEM--IVCSGKKS--------H---L 51 (277) T ss_dssp CCCCCEEEEEECSSCT------------TTHHHHHHHHHHHHHTT--------TCEE--EEEESTTT--------T---T T ss_pred cCCCCEEEEEECCCCC------------chHHHHHHHHHHHHHhc--------CCEE--EEEeCCch--------h---h Confidence 3567899999986432 25566777888777764 2333 33332211 0 1 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) .+.. ++++++|...... .......+...++|+|..+...+. +..+++..++.. T Consensus 52 ~~~~-------------------~~~d~ii~~~~~~-~~~~~~~~~~~~ip~v~~~~~~~~-------~~~~~v~~d~~~ 104 (277) T 3CS3_A 52 FIPE-------------------KMVDGAIILDWTF-PTKEIEKFAERGHSIVVLDRTTEH-------RNIRQVLLDNRG 104 (277) T ss_dssp CCCT-------------------TTCSEEEEECTTS-CHHHHHHHHHTTCEEEESSSCCCS-------TTEEEEEECHHH T ss_pred cccc-------------------cccCEEEEeCCCC-ChHHHHHHHHCCCeEEEECCCCCc-------cCCcEEEeCcHH Confidence 1111 4678777633222 223445566789999988764431 345677777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET--PNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~--~~~~v 277 (908) .++.+++++.+.+.++++++..... ....+.+++++.+++. ++++... ... .+..+....++++++. .++++ T Consensus 105 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~-~~~--~~~~~~~~~~~~~l~~~~~~~~~ 180 (277) T 3CS3_A 105 GATQAIEQFVNVGSKKVLLLSGPEKGYDSQERLAVSTRELTRF-GIPYEII-QGD--FTEPSGYAAAKKILSQPQTEPVD 180 (277) T ss_dssp HHHHHHHHHHHTTCSCEEEEECCTTSHHHHHHHHHHHHHHHHT-TCCEEEE-ECC--SSHHHHHHHHHHHTTSCCCSSEE T ss_pred HHHHHHHHHHHCCCCeEEEEcCCCCCCCHHHHHHHHHHHHHHc-CCCCeEE-ecC--CChHHHHHHHHHHHcCCCCCCcE Confidence 8888888886667889999885432 4566778888887764 3443211 111 1112333445555432 25677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++. ++..+..+++++++.|+. T Consensus 181 i~~~-~~~~a~~~~~~l~~~g~~ 202 (277) T 3CS3_A 181 VFAF-NDEMAIGVYKYVAETNYQ 202 (277) T ss_dssp EEES-SHHHHHHHHHHHTTSSCC T ss_pred EEEe-CHHHHHHHHHHHHHCCCC Confidence 5554 455567788888877764 No 289 >2H0A_A Transcriptional regulator; Transcription, regulator, repressor, Structural Genomics; 2.8A {Thermus thermophilus} Probab=96.30 E-value=2.4e-05 Score=76.97 Aligned_cols=144 Identities=12% Similarity=0.039 Sum_probs=83.5 Template_Neff=12.000 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++|++|........ .....+...++|+|..+... +.++.+..++...++.+++++.+.+.++++++..+ T Consensus 54 ~~~d~ii~~~~~~~~-~~~~~~~~~~ipvv~~~~~~---------~~~~~v~~d~~~~~~~~~~~l~~~g~~~i~~~~~~ 123 (276) T 2H0A_A 54 YLTDGLILASYDLTE-RFEEGRLPTERPVVLVDAQN---------PRYDSVYLDNRLGGRLAGAYLARFPGPIFAIAVEE 123 (276) T ss_dssp CCCSEEEEESCCCC-------CCSCSSCEEEESSCC---------TTSEEEEECSHHHHHHHHHHHTTSSSCEEEEEECC T ss_pred hcCCEEEEeccCCCh-HHHHccCCcCCCEEEECCCC---------CCCCEEEEChHHHHHHHHHHHHhCCCCEEEEEeCC Confidence 478888865433322 23344566799999876542 23456667777778888888876688889888743 Q NP_000836.2 225 -------GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAVIMFANEDDIRRILEAAKK 296 (908) Q Consensus 225 -------~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~viv~~~~~~~~~~~l~~~~~ 296 (908) ..+...+.+++++.+++. ++.+.....+....+..+....++++++. .++++|++.. +..+..+++++++ T Consensus 124 ~~~~~~~~~~~~~r~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~~-~~~a~~~~~~~~~ 201 (276) T 2H0A_A 124 EPDRAFRRTVFAERMAGFQEALKEA-GRPFSPDRLYITRHSQEGGRLALRHFLEKASPPLNVFAGA-DQVALGVLEEAVR 201 (276) T ss_dssp SCCC---CCHHHHHHHHHHHHHHHT-TCCCCGGGEEEECSSHHHHHHHHHHHHTTCCSSEEEECSS-HHHHHHHHHHHHT T ss_pred CCchHhhhhHHHHHHHHHHHHHHHc-CCCCChhheEEecCChHHHHHHHHHHHHhcCCCCEEEECC-HHHHHHHHHHHHH Confidence 234556778888888765 34432211111001112233444555421 2477776653 4456678888888 Q NP_000836.2 297 LNQS 300 (908) Q Consensus 297 ~g~~ 300 (908) .|+. T Consensus 202 ~g~~ 205 (276) T 2H0A_A 202 LGLT 205 (276) T ss_dssp TSCT T ss_pred CCCC Confidence 7764 No 290 >3E61_B Putative transcriptional repressor of ribose; STRUCTURAL GENOMICS, TRANSCRIPTION, DNA-binding, Transcription; HET: GOL; 2.0A {Staphylococcus saprophyticus subsp. saprophyticus} Probab=96.28 E-value=2.5e-05 Score=77.04 Aligned_cols=197 Identities=11% Similarity=0.029 Sum_probs=106.2 Template_Neff=11.300 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++.+||++.|..+. .+......+++.++++.+ + ++.+.+...+. ....+.+ T Consensus 4 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~ 57 (277) T 3E61_B 4 YKRKSKLIGLLLPDMSN------------PFFTLIARGVEDVALAHG--------Y--QVLIGNSDNDI----KKAQGYL 57 (277) T ss_dssp ------CEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------C--CEEEEECTTCH----HHHHHHH T ss_pred CCCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHCC--------C--eEEEEeCCCCH----HHHHHHH Confidence 34567899999986432 245567777777776642 2 33344433321 2223344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .++|++|....+.. .....+...++|+|..+...+ ....+..++. T Consensus 58 ~~l~~-------------------~~~d~ii~~~~~~~--~~~~~~~~~~ipvv~~~~~~~---------~~~~v~~d~~ 107 (277) T 3E61_B 58 ATFVS-------------------HNCTGMISTAFNEN--IIENTLTDHHIPFVFIDRINN---------EHNGISTNHF 107 (277) T ss_dssp HHHHH-------------------TTCSEEEECGGGHH--HHHHHHHHTTCCEEECC---------------CBCCCCHH T ss_pred HHHHH-------------------cCCCEEEEeCCCch--HHHHHHHHCCCCEEEECCCCC---------CCCEEEeChH Confidence 43332 47888876543322 223455678999998775432 2345666667 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ..++.+++++.+.+.++++++.... .....+.+++++.+++. ++.+.... .. .........+.+. ..++++| T Consensus 108 ~~~~~~~~~l~~~~~~~v~~~~~~~~~~~~~~r~~~~~~~~~~~-~~~~~~~~-~~---~~~~~~~~~~~l~-~~~~~ai 181 (277) T 3E61_B 108 KGGQLQAEVVRKGKGKNVLIVHENLLIDAFHQRVQGIKYILDQQ-RIDYKMLE-AT---LLDNDKKFIDLIK-ELSIDSI 181 (277) T ss_dssp HHHHHHHHHHHHTTCSEEEEEECCTTSHHHHHHHHHHHHHHHHT-TCEEEEEE-GG---GGSSHHHHHHHHH-HTTCCEE T ss_pred HHHHHHHHHHHcCCCCeEEEEeCCCCChHHHHHHHHHHHHHHHC-CCChHHHh-hh---cccchHHHHHHHh-hCCCCEE Confidence 7777788887665667888887532 34556777888777764 34332111 11 0111222222232 2467888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|.. T Consensus 182 ~~~~-d~~a~~~~~al~~~g~~ 202 (277) T 3E61_B 182 ICSN-DLLAINVLGIVQRYHFK 202 (277) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHcCCC Confidence 7764 44566777888777763 No 291 >3E61_A Putative transcriptional repressor of ribose; STRUCTURAL GENOMICS, TRANSCRIPTION, DNA-binding, Transcription; HET: GOL; 2.0A {Staphylococcus saprophyticus subsp. saprophyticus} Probab=96.28 E-value=2.5e-05 Score=77.04 Aligned_cols=197 Identities=11% Similarity=0.029 Sum_probs=101.8 Template_Neff=11.300 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++.+||++.|..+. .+......+++.++++.+ + ++.+.+...+. ....+.+ T Consensus 4 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~ 57 (277) T 3E61_A 4 YKRKSKLIGLLLPDMSN------------PFFTLIARGVEDVALAHG--------Y--QVLIGNSDNDI----KKAQGYL 57 (277) T ss_dssp ------CEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------C--CEEEEECTTCH----HHHHHHH T ss_pred CCCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHCC--------C--eEEEEeCCCCH----HHHHHHH Confidence 34567899999986432 245567777777776642 2 33344433321 2223344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .++|++|....+.. .....+...++|+|..+...+ ....+..++. T Consensus 58 ~~l~~-------------------~~~d~ii~~~~~~~--~~~~~~~~~~ipvv~~~~~~~---------~~~~v~~d~~ 107 (277) T 3E61_A 58 ATFVS-------------------HNCTGMISTAFNEN--IIENTLTDHHIPFVFIDRINN---------EHNGISTNHF 107 (277) T ss_dssp HHHHH-------------------TTCSEEEECGGGHH--HHHHHHHHC-CCEEEGGGCC------------------HH T ss_pred HHHHH-------------------cCCCEEEEeCCCch--HHHHHHHHCCCCEEEECCCCC---------CCCEEEeChH Confidence 43332 47888876543322 223455678999998775432 2345666667 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ..++.+++++.+.+.++++++.... .....+.+++++.+++. ++.+.... .. .........+.+. ..++++| T Consensus 108 ~~~~~~~~~l~~~~~~~v~~~~~~~~~~~~~~r~~~~~~~~~~~-~~~~~~~~-~~---~~~~~~~~~~~l~-~~~~~ai 181 (277) T 3E61_A 108 KGGQLQAEVVRKGKGKNVLIVHENLLIDAFHQRVQGIKYILDQQ-RIDYKMLE-AT---LLDNDKKFIDLIK-ELSIDSI 181 (277) T ss_dssp HHHHHHHHHHHHTTCCSEEEEESCTTSHHHHHHHHHHHHHHHC----CEEEEE-GG---GGGSHHHHHHHHH-HHTCCEE T ss_pred HHHHHHHHHHHcCCCCeEEEEeCCCCChHHHHHHHHHHHHHHHC-CCChHHHh-hh---cccchHHHHHHHh-hCCCCEE Confidence 7777788887665667888887532 34556777888777764 34332111 11 0111222222232 2467888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|.. T Consensus 182 ~~~~-d~~a~~~~~al~~~g~~ 202 (277) T 3E61_A 182 ICSN-DLLAINVLGIVQRYHFK 202 (277) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHcCCC Confidence 7764 44566777888777763 No 292 >6HNI_A ABC-type transport system, sugar-family extracellular; Substrate binding protein, adhesin, tyrosine; HET: TYR, EDO; 1.35A {Peptoclostridium difficile 630} Probab=96.19 E-value=3.4e-05 Score=77.89 Aligned_cols=218 Identities=9% Similarity=0.062 Sum_probs=114.9 Template_Neff=11.800 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....+.++||++.|.++ .++.....+++.++++.+.. .|+++++.+.|...+. ....+ T Consensus 17 ~~~~~~~~~Igvv~~~~~-------------~~~~~~~~g~~~~~~~~g~~----~g~~i~~~~~~~~~~~----~~~~~ 75 (319) T 6HNI_A 17 NSKDKEVKKIGITQLVEH-------------PALDATRTGFVKALEKNGFK----DGENIDIDFQNAQNDM----PTTQS 75 (319) T ss_pred HhhcCCceEEEEEecCCC-------------HHHHHHHHHHHHHHHHhCCC----CCceEEEEEECCCCCH----HHHHH Confidence 345667899999998653 24556777777777664321 1345666666654332 22233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN---TRYDFFSRV 195 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~---~~~~~~~~~ 195 (908) .++++.. .++|++|+...... ..... ...++|+|..+...+..... ...++.+.+ T Consensus 76 ~~~~~~~-------------------~~~d~ii~~~~~~~-~~~~~--~~~~ipvv~~~~~~~~~~~~~~~~~~~~~~~~ 133 (319) T 6HNI_A 76 IASKFAS-------------------DKKDLIFAISTPSA-QAAFN--ATKDIPILITAVSDPVAAGLVKTLEKPGTNVS 133 (319) T ss_pred HHHHHHH-------------------CCCCEEEEeCCchH-HHHHH--HHcCCCEEEEcCCCCCccccccCCCCCCcCee Confidence 3333322 47888876443322 22222 25799998876544321100 001122444 Q NP_000836.2 196 VPPDSYQAQAMVDIVTAL--GWNYVSTLASEGNYG-ESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~--~~~~v~ii~~~~~~~-~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) ..+....++.+++++.+. +.++++++..+...+ ..+.+++++.+++. ++++..... .+..+....++++. T Consensus 134 ~~~~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~----~~~~~~~~~i~~~~-- 206 (319) T 6HNI_A 134 GTSDFVSVDKGLELLKIFAPKAKTIGVMYNTSEVNSKVQVDALKEYASKN-GFKVVEKGI----TTSNEVNQGISSLV-- 206 (319) T ss_pred ecCHHHHHHHHHHHHHHHCCCCcEEEEEeCCCChHHHHHHHHHHHHHHcC-CCEEeeeeC----CCHHHHHHHHHHhC-- Confidence 455555566677777554 788999998544332 34566777776654 344432111 11122334444442 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIG 307 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~ 307 (908) .++++|++.. +..+..+++++++.+...++.+++ T Consensus 207 ~~~~~i~~~~-~~~a~~~~~~~~~~~~~~~v~v~~ 240 (319) T 6HNI_A 207 GKIDVLYVPT-DNLVASSMPIVSKIATENKIPVIA 240 (319) T ss_pred CCCCEEEECC-hHHHHHHHHHHHHCCCCCCceEEE Confidence 3678887664 334556666776665532333443 No 293 >6HNJ_A ABC-type transport system, sugar-family extracellular; Substrate binding protein, adhesin, tyrosine; HET: PGE, EDO; 1.8A {Peptoclostridium difficile 630} Probab=96.19 E-value=3.4e-05 Score=77.89 Aligned_cols=218 Identities=9% Similarity=0.062 Sum_probs=114.9 Template_Neff=11.800 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....+.++||++.|.++ .++.....+++.++++.+.. .|+++++.+.|...+. ....+ T Consensus 17 ~~~~~~~~~Igvv~~~~~-------------~~~~~~~~g~~~~~~~~g~~----~g~~i~~~~~~~~~~~----~~~~~ 75 (319) T 6HNJ_A 17 NSKDKEVKKIGITQLVEH-------------PALDATRTGFVKALEKNGFK----DGENIDIDFQNAQNDM----PTTQS 75 (319) T ss_pred HhhcCCceEEEEEecCCC-------------HHHHHHHHHHHHHHHHhCCC----CCceEEEEEECCCCCH----HHHHH Confidence 345667899999998653 24556777777777664321 1345666666654332 22233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN---TRYDFFSRV 195 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~---~~~~~~~~~ 195 (908) .++++.. .++|++|+...... ..... ...++|+|..+...+..... ...++.+.+ T Consensus 76 ~~~~~~~-------------------~~~d~ii~~~~~~~-~~~~~--~~~~ipvv~~~~~~~~~~~~~~~~~~~~~~~~ 133 (319) T 6HNJ_A 76 IASKFAS-------------------DKKDLIFAISTPSA-QAAFN--ATKDIPILITAVSDPVAAGLVKTLEKPGTNVS 133 (319) T ss_pred HHHHHHH-------------------CCCCEEEEeCCchH-HHHHH--HHcCCCEEEEcCCCCCccccccCCCCCCcCee Confidence 3333322 47888876443322 22222 25799998876544321100 001122444 Q NP_000836.2 196 VPPDSYQAQAMVDIVTAL--GWNYVSTLASEGNYG-ESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~--~~~~v~ii~~~~~~~-~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) ..+....++.+++++.+. +.++++++..+...+ ..+.+++++.+++. ++++..... .+..+....++++. T Consensus 134 ~~~~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~----~~~~~~~~~i~~~~-- 206 (319) T 6HNJ_A 134 GTSDFVSVDKGLELLKIFAPKAKTIGVMYNTSEVNSKVQVDALKEYASKN-GFKVVEKGI----TTSNEVNQGISSLV-- 206 (319) T ss_pred ecCHHHHHHHHHHHHHHHCCCCcEEEEEeCCCChHHHHHHHHHHHHHHcC-CCEEeeeeC----CCHHHHHHHHHHhC-- Confidence 455555566677777554 788999998544332 34566777776654 344432111 11122334444442 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIG 307 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~ 307 (908) .++++|++.. +..+..+++++++.+...++.+++ T Consensus 207 ~~~~~i~~~~-~~~a~~~~~~~~~~~~~~~v~v~~ 240 (319) T 6HNJ_A 207 GKIDVLYVPT-DNLVASSMPIVSKIATENKIPVIA 240 (319) T ss_pred CCCCEEEECC-hHHHHHHHHHHHHCCCCCCceEEE Confidence 3678887664 334556666776665532333443 No 294 >3H75_A Periplasmic sugar-binding domain protein; Protein Structure Initiative II (PSI; HET: SO4; 1.6A {Pseudomonas fluorescens Pf-5} Probab=96.16 E-value=3.8e-05 Score=78.89 Aligned_cols=212 Identities=15% Similarity=0.069 Sum_probs=109.7 Template_Neff=10.900 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ..++||++.|.... ..+...+..+++.++++.+ + ++.+.+...++ ....+.++++ T Consensus 2 ~~~~I~~i~~~~~~-----------~~~~~~~~~g~~~~a~~~g--------~--~~~~~~~~~~~----~~~~~~~~~l 56 (350) T 3H75_A 2 SLTSVVFLNPGNST-----------ETFWVSYSQFMQAAARDLG--------L--DLRILYAERDP----QNTLQQAREL 56 (350) T ss_dssp -CCEEEEEECSCTT-----------CHHHHHHHHHHHHHHHHHT--------C--EEEEEECTTCH----HHHHHHHHHH T ss_pred CCeEEEEEcCCCCC-----------CHHHHHHHHHHHHHHHHhC--------C--EEEEEEcCCCH----HHHHHHHHHH Confidence 46789999986211 1245667777777777642 2 33444443332 1222333333 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSD-------NTRYDFFSRVV 196 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~-------~~~~~~~~~~~ 196 (908) +.. ..++|++|..............+...+||+|..+...+.... ....+++..+. T Consensus 57 ~~~-----------------~~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~~~~~~~~~~~~~~~~~v~ 119 (350) T 3H75_A 57 FQG-----------------RDKPDYLMLVNEQYVAPQILRLSQGSGIKLFIVNSPLTLDQRELIGQSRQNYSDWIGSMV 119 (350) T ss_dssp HHS-----------------SSCCSEEEEECCSSHHHHHHHHHTTSCCEEEEEESCCCTTTC------------CEEEEE T ss_pred HcC-----------------CCCCCEEEEeCCcccHHHHHHHHHhcCCeEEEECCCCCHHHHHHhcCcchhcccchhEee Confidence 210 046788776543322223445566789999987754332100 00012345666 Q NP_000836.2 197 PPDSYQAQAMVDIVTA-LGWN------YVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIK 267 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~-~~~~------~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~ 267 (908) .++...+..+++++.+ .+.+ +++++.. +......+.++|++.+++.+...+.... .. ..+..+....++ T Consensus 120 ~d~~~~g~~~~~~l~~~~g~~~~~~~~~i~~i~~~~~~~~~~~r~~g~~~~l~~~~~~~~~~~~-~~-~~~~~~~~~~~~ 197 (350) T 3H75_A 120 GDDEEAGYRMLKELLHKLGPVPAGHGIELLAFSGLKVTPAAQLRERGLRRALAEHPQVHLRQLV-YG-EWNRERAYRQAQ 197 (350) T ss_dssp CCHHHHHHHHHHHHHHHHCCCCSSCCEEEEEEESCTTSHHHHHHHHHHHHHHHHCTTEEEEEEE-EC-TTCHHHHHHHHH T ss_pred CCHHHHHHHHHHHHHHHhCCCCCCCCcEEEEEeCCCCCHHHHHHHHHHHHHHHhCCCeEEEEEE-eC-CCCHHHHHHHHH Confidence 6777777777777643 4432 6777764 2334556778888887764312221111 11 011122334445 Q NP_000836.2 268 RLLE-TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 268 ~l~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++++ ..++++|++.. +..+..+++++++.|+. T Consensus 198 ~~l~~~~~~~~i~~~~-d~~a~~~~~al~~~g~~ 230 (350) T 3H75_A 198 QLLKRYPKTQLVWSAN-DEMALGAMQAARELGRK 230 (350) T ss_dssp HHHHHCTTEEEEEESS-HHHHHHHHHHHHHTTCC T ss_pred HHHHHCCCCcEEEECC-HHHHHHHHHHHHHcCCC Confidence 5542 12466666553 44566778888887764 No 295 >4RKQ_A Transcriptional regulator, LacI family; sugar binding, transcription regulation, Enzyme; HET: EDO; 1.903A {Arthrobacter sp.} Probab=96.09 E-value=4.6e-05 Score=75.83 Aligned_cols=199 Identities=12% Similarity=0.049 Sum_probs=110.8 Template_Neff=11.600 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++..+||++.|..+. .+...+..+++.++++.+ + ++.+.+...++. ...+. T Consensus 10 l~~~~~~~I~~i~~~~~~------------~~~~~~~~~~~~~~~~~g--------~--~~~~~~~~~~~~----~~~~~ 63 (294) T 4RKQ_A 10 LVQGARTSVGLAIPDLTN------------PYFPAFASSVVELATLRG--------W--HVVVDDYGHGGR----SGLDA 63 (294) T ss_dssp SCCSCCCEEEEEESCSSS------------THHHHHHHHHHHHHHHTT--------C--EEEEEECCSTTC----CHHHH T ss_pred HccCCCCeEEEEeCCCCC------------ccHHHHHHHHHHHHHHcC--------C--eEEEEeCCCChh----hHHHH Confidence 345678999999986432 245566777777766542 2 334444333221 22223 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++.+ . +++|++|....+... .... . ..++|+|..+...+ +..+.+..+. T Consensus 64 ~~~~-~-------------------~~~d~ii~~~~~~~~-~~~~-~-~~~ipvv~~~~~~~--------~~~~~v~~d~ 112 (294) T 4RKQ_A 64 VEHL-A-------------------PQVDAVIGYLGGYAD-QAQT-V-LGRRPLIVLDENPG--------GAAGSINFDY 112 (294) T ss_dssp HHHH-G-------------------GGCSEEEECCTTCHH-HHHH-H-HTTSCEEEESSCCT--------TCSEEEEECH T ss_pred HHHH-h-------------------hcCCEEEEeCCCchh-HHHH-H-hcCCCEEEECCCCC--------CCCCEEEeCH Confidence 3322 1 467887764333221 1111 2 46899988765332 2455667777 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGN-------YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE- 271 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~-------~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~- 271 (908) ...++.+++++.+.+.++++++..+.. +...+.+++.+.+++. ++.+... ... .+..+....+++++. T Consensus 113 ~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~-~~~--~~~~~~~~~~~~~l~~ 188 (294) T 4RKQ_A 113 QHAAKVAVAQLMDSKRQHIAYLEAGSASESDEPVPCTVRGKAVAGRLDEL-GASWSLI-VAE--ETAEAAREAAAAFLRE 188 (294) T ss_dssp HHHHHHHHHHHHHTTCSSEEEEEESCCTTSSSCCCCSHHHHHHHHHHHHT-TCCEEEE-EEC--SSHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHCCCCeEEEEecCCCCCCCCCCcchHHHHHHHHHHHHh-CCCceEE-ecC--ccHHHHHHHHHHHHHH Confidence 777888888876667889999885332 3456667777777765 3433211 111 111223344444442 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ..++++|++.. +..+..+++++++.|+. T Consensus 189 ~~~~~~i~~~~-~~~a~~~~~al~~~g~~ 216 (294) T 4RKQ_A 189 HPETDGILAFN-DLMAAGVLKALSGSGRR 216 (294) T ss_dssp CTTCCEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CCCCcEEEECC-HHHHHHHHHHHHHCCCC Confidence 12467776653 44566778888887764 No 296 >4RKQ_B Transcriptional regulator, LacI family; sugar binding, transcription regulation, Enzyme; HET: EDO; 1.903A {Arthrobacter sp.} Probab=96.09 E-value=4.6e-05 Score=75.83 Aligned_cols=199 Identities=12% Similarity=0.049 Sum_probs=108.6 Template_Neff=11.600 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++..+||++.|..+. .+...+..+++.++++.+ + ++.+.+...++. ...+. T Consensus 10 l~~~~~~~I~~i~~~~~~------------~~~~~~~~~~~~~~~~~g--------~--~~~~~~~~~~~~----~~~~~ 63 (294) T 4RKQ_B 10 LVQGARTSVGLAIPDLTN------------PYFPAFASSVVELATLRG--------W--HVVVDDYGHGGR----SGLDA 63 (294) T ss_dssp ----CCCEEEEEESCSSS------------THHHHHHHHHHHHHHHTT--------C--EEEEEECCSTTC----CHHHH T ss_pred HccCCCCeEEEEeCCCCC------------ccHHHHHHHHHHHHHHcC--------C--eEEEEeCCCChh----hHHHH Confidence 345678999999986432 245566777777766542 2 334444333221 22223 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++.+ . +++|++|....+... .... . ..++|+|..+...+ +..+.+..+. T Consensus 64 ~~~~-~-------------------~~~d~ii~~~~~~~~-~~~~-~-~~~ipvv~~~~~~~--------~~~~~v~~d~ 112 (294) T 4RKQ_B 64 VEHL-A-------------------PQVDAVIGYLGGYAD-QAQT-V-LGRRPLIVLDENPG--------GAAGSINFDY 112 (294) T ss_dssp HHHH-G-------------------GGCSEEEECCSSCHH-HHHH-H-HTTSCEEEESSCCT--------TCSEEEEECH T ss_pred HHHH-h-------------------hcCCEEEEeCCCchh-HHHH-H-hcCCCEEEECCCCC--------CCCCEEEeCH Confidence 3322 1 467887764333221 1111 2 46899988765332 2455667777 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGN-------YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE- 271 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~-------~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~- 271 (908) ...++.+++++.+.+.++++++..+.. +...+.+++.+.+++. ++.+... ... .+..+....+++++. T Consensus 113 ~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~-~~~--~~~~~~~~~~~~~l~~ 188 (294) T 4RKQ_B 113 QHAAKVAVAQLMDSKRQHIAYLEAGSASESDEPVPCTVRGKAVAGRLDEL-GASWSLI-VAE--ETAEAAREAAAAFLRE 188 (294) T ss_dssp HHHHHHHHHHHHHTTCCSEEEEEECC------CCCCSHHHHHHHHHHHHH-TCCEEEE-EEC--SSHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHCCCCeEEEEecCCCCCCCCCCcchHHHHHHHHHHHHh-CCCceEE-ecC--ccHHHHHHHHHHHHHH Confidence 777888888876667889999885332 3456667777777765 3433211 111 111223344444442 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ..++++|++.. +..+..+++++++.|+. T Consensus 189 ~~~~~~i~~~~-~~~a~~~~~al~~~g~~ 216 (294) T 4RKQ_B 189 HPETDGILAFN-DLMAAGVLKALSGSGRR 216 (294) T ss_dssp CTTCCEEEESS-HHHHHHHHHHHHHHTCC T ss_pred CCCCcEEEECC-HHHHHHHHHHHHHCCCC Confidence 12467776653 44566778888887764 No 297 >3LFT_A uncharacterized protein; ABC, ATPase, cassette, L-Trp, PSI; HET: TRP; 1.35A {Streptococcus pneumoniae} Probab=96.03 E-value=5.4e-05 Score=75.11 Aligned_cols=202 Identities=15% Similarity=0.156 Sum_probs=105.7 Template_Neff=12.200 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) ..+||++.|.+. .++....++++.++++.+.. |.++++.+.|+..++. ...+.++++. T Consensus 2 ~~~I~~i~~~~~-------------~~~~~~~~~~~~~~~~~g~~-----~~~~~~~~~d~~~~~~----~~~~~~~~~~ 59 (295) T 3LFT_A 2 NAKIGVLQFVSH-------------PSLDLIYKGIQDGLAEEGYK-----DDQVKIDFMNSEGDQS----KVATMSKQLV 59 (295) T ss_dssp CEEEEEEECSCC-------------HHHHHHHHHHHHHHHHTTCC-----GGGEEEEEEECTTCHH----HHHHHHHHHT T ss_pred CcEEEEEEccCC-------------HHHHHHHHHHHHHHHHcCCc-----cCeEEEEEECCCCCHH----HHHHHHHHHH Confidence 568999988742 25567788888888876422 2346666666543322 2223333332 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN---TRYDFFSRVVPPDSY 201 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~---~~~~~~~~~~~~~~~ 201 (908) . .++|++|+.... ....+.. + ..++|+|..+...+..... ...+..+.+..+... T Consensus 60 ~-------------------~~~d~ii~~~~~-~~~~~~~-~-~~~ipvv~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 117 (295) T 3LFT_A 60 A-------------------NGNDLVVGIATP-AAQGLAS-A-TKDLPVIMAAITDPIGANLVKDLKKPGGNVTGVSDHN 117 (295) T ss_dssp T-------------------SSCSEEEEESHH-HHHHHHH-H-CSSSCEEEESCSCTTTTTSCSCSSCCCSSEEEEEECC T ss_pred H-------------------CCCCEEEEeCCH-HHHHHHH-h-cCCCCEEEEEcCChhhcchhhhccCCCCCcceecCCC Confidence 2 478888864332 2222222 2 5799998876544321100 000111223333334 Q NP_000836.2 202 QAQAMVDIVTAL--GWNYVSTLASEGNYG-ESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~--~~~~v~ii~~~~~~~-~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) .++.+++++.+. +.+++++++.+..++ ..+.+++++.+++. ++++.... .. +..+....++++. .++++| T Consensus 118 ~~~~~~~~l~~~~~~~~~v~~l~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~-~~---~~~~~~~~~~~~~--~~~~~i 190 (295) T 3LFT_A 118 PAQQQVELIKALTPNVKTIGALYSSSEDNSKTQVEEFKAYAEKA-GLTVETFA-VP---STNEIASTVTVMT--SKVDAI 190 (295) T ss_dssp CHHHHHHHHHHHCTTCCEEEEEEETTCHHHHHHHHHHHHHHHHT-TCEEEEEE-ES---SGGGHHHHHHHHT--TTCSEE T ss_pred cHHHHHHHHHHHCCCCcEEEEeecCCCCChHHHHHHHHHHHHHc-CCEEEEEE-eC---CHHHHHHHHHHhc--cCCCEE Confidence 455666666554 678899998654433 45667777777664 34443211 11 1123444444442 367777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g 298 (908) ++.. +..+..+++++.+.+ T Consensus 191 ~~~~-~~~~~~~~~~~~~~~ 209 (295) T 3LFT_A 191 WVPI-DNTIASGFPTVVSSN 209 (295) T ss_dssp EECS-CHHHHHTHHHHHHHT T ss_pred EECC-ChhhhcchhHHHHHH Confidence 6654 333444555555544 No 298 >3LFT_B uncharacterized protein; ABC, ATPase, cassette, L-Trp, PSI; HET: MSE, TRP; 1.35A {Streptococcus pneumoniae} Probab=96.03 E-value=5.4e-05 Score=75.11 Aligned_cols=202 Identities=15% Similarity=0.156 Sum_probs=103.1 Template_Neff=12.200 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) ..+||++.|.+. .++....++++.++++.+.. |.++++.+.|+..++. ...+.++++. T Consensus 2 ~~~I~~i~~~~~-------------~~~~~~~~~~~~~~~~~g~~-----~~~~~~~~~d~~~~~~----~~~~~~~~~~ 59 (295) T 3LFT_B 2 NAKIGVLQFVSH-------------PSLDLIYKGIQDGLAEEGYK-----DDQVKIDFMNSEGDQS----KVATMSKQLV 59 (295) T ss_dssp --CEEEEECSCC-------------HHHHHHHHHHHHHHHHTTC---------CCEEEEECTTCHH----HHHHHHHHHH T ss_pred CcEEEEEEccCC-------------HHHHHHHHHHHHHHHHcCCc-----cCeEEEEEECCCCCHH----HHHHHHHHHH Confidence 568999988742 25567788888888876422 2346666666543322 2223333332 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN---TRYDFFSRVVPPDSY 201 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~---~~~~~~~~~~~~~~~ 201 (908) . .++|++|+.... ....+.. + ..++|+|..+...+..... ...+..+.+..+... T Consensus 60 ~-------------------~~~d~ii~~~~~-~~~~~~~-~-~~~ipvv~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 117 (295) T 3LFT_B 60 A-------------------NGNDLVVGIATP-AAQGLAS-A-TKDLPVIMAAITDPIGANLVKDLKKPGGNVTGVSDHN 117 (295) T ss_dssp H-------------------SSCSEEEEESHH-HHHHHHH-H-CSSSCEEEESCSCTTTTTSCSCSSCCCSSEEEEEECC T ss_pred H-------------------CCCCEEEEeCCH-HHHHHHH-h-cCCCCEEEEEcCChhhcchhhhccCCCCCcceecCCC Confidence 2 478888864332 2222222 2 5799998876544321100 000111223333334 Q NP_000836.2 202 QAQAMVDIVTAL--GWNYVSTLASEGNYG-ESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~--~~~~v~ii~~~~~~~-~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) .++.+++++.+. +.+++++++.+..++ ..+.+++++.+++. ++++.... .. +..+....++++. .++++| T Consensus 118 ~~~~~~~~l~~~~~~~~~v~~l~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~-~~---~~~~~~~~~~~~~--~~~~~i 190 (295) T 3LFT_B 118 PAQQQVELIKALTPNVKTIGALYSSSEDNSKTQVEEFKAYAEKA-GLTVETFA-VP---STNEIASTVTVMT--SKVDAI 190 (295) T ss_dssp CHHHHHHHHHHHCTTCCEEEEEEETTCHHHHHHHHHHHHHHHHT-TCEEEEEE-ES---SGGGHHHHHHHHH--TTCSEE T ss_pred cHHHHHHHHHHHCCCCcEEEEeecCCCCChHHHHHHHHHHHHHc-CCEEEEEE-eC---CHHHHHHHHHHhc--cCCCEE Confidence 455666666554 678899998654433 45667777777664 34443211 11 1123444444442 367777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g 298 (908) ++.. +..+..+++++.+.+ T Consensus 191 ~~~~-~~~~~~~~~~~~~~~ 209 (295) T 3LFT_B 191 WVPI-DNTIASGFPTVVSSN 209 (295) T ss_dssp EECS-CHHHHHTHHHHHHHT T ss_pred EECC-ChhhhcchhHHHHHH Confidence 6654 333444555555544 No 299 >3HS3_B Ribose operon repressor; PSI-II, NYSGXRC, 11235h, periplasmic binding; 1.6A {Lactobacillus acidophilus} Probab=95.74 E-value=0.00012 Score=71.98 Aligned_cols=195 Identities=13% Similarity=0.113 Sum_probs=106.9 Template_Neff=11.500 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...+..+||++.|..+. .+......+++.++++. |+++.+...+. .++ ....+.+ T Consensus 6 ~~~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~~~~~~~~~-~~~----~~~~~~i 60 (277) T 3HS3_B 6 YQKKSKMIGIIIPDLNN------------RFYAQIIDGIQEVIQKE--------GYTALISFSTN-SDV----KKYQNAI 60 (277) T ss_dssp --CCCCEEEEEESCSCS------------HHHHHHHHHHHHHHHHT--------TCEEEEEECSS-CCH----HHHHHHH T ss_pred ccCCCCeEEEEeCCCCC------------hhHHHHHHHHHHHHHHc--------CCEEEEEecCC-CcH----HHHHHHH Confidence 34567899999986432 24556777777777664 23343332221 221 1222334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .++|++|....+... ....++|+|..+...+. +....+..+.. T Consensus 61 ~~l~~-------------------~~~d~ii~~~~~~~~------~~~~~ipvv~~~~~~~~-------~~~~~v~~d~~ 108 (277) T 3HS3_B 61 INFEN-------------------NNVDGIITSAFTIPP------NFHLNTPLVMYDSANIN-------DDIVRIVSNNT 108 (277) T ss_dssp HHHHH-------------------TTCSEEEEECCCCCT------TCCCSSCEEEESCCCCC-------SSSEEEEECHH T ss_pred HHHHH-------------------CCCCEEEEeCCCCCc------ccccCCCEEEecCCCCC-------CCceEEEeccH Confidence 43332 478888865433221 13569999987764321 23455666777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASE--GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~--~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) ..++.+++++.+. .++++++... ......+.++|++.+++. ++.+.... .. .......+.++++ ..++++ T Consensus 109 ~~~~~~~~~l~~~-~~~i~~i~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~-~~----~~~~~~~~~~~l~~~~~~~~ 181 (277) T 3HS3_B 109 KGGKESIKLLSKK-IEKVLIQHWPLSLPTIRERIEAMTAEASKL-KIDYLLEE-TP----ENNPYISAQSALNKSNQFDA 181 (277) T ss_dssp HHHHHHHHTSCTT-CCEEEEEESCTTSHHHHHHHHHHHHHHHHT-TCEEEEEE-CC----SSCHHHHHHHHHHTGGGCSE T ss_pred HHHHHHHHHHHhc-CceEEEEeCCCCCHHHHHHHHHHHHHHHHC-CCceeecC-CC----CCCHHHHHHHHHhhCCCCCE Confidence 7777777777553 5788888743 334456777888877765 34432111 11 0111122233322 135777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 182 i~~~~-d~~a~~~~~al~~~g~~ 203 (277) T 3HS3_B 182 IITVN-DLYAAEIIKEAKRRNLK 203 (277) T ss_dssp EECSS-HHHHHHHHHHHHHTTCC T ss_pred EEEcC-HHHHHHHHHHHHHCCCC Confidence 76663 44566778888887763 No 300 >3JVD_A Transcriptional regulators; STRUCTURAL GENOMICS, PSI-2, SUGAR BINDING; HET: SO4; 2.3A {Corynebacterium glutamicum} Probab=95.72 E-value=0.00012 Score=74.15 Aligned_cols=192 Identities=13% Similarity=0.121 Sum_probs=105.9 Template_Neff=11.400 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .+..+||++.|..+. .++..+..+++.++++. |+++. +.+.. ++ +...+.+++ T Consensus 62 ~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~~~--~~~~~-~~----~~~~~~~~~ 114 (333) T 3JVD_A 62 HRSALVGVIVPDLSN------------EYYSESLQTIQQDLKAA--------GYQML--VAEAN-SV----QAQDVVMES 114 (333) T ss_dssp --CCEEEEEESCSSS------------HHHHHHHHHHHHHHHHH--------TCEEE--EEECC-SH----HHHHHHHHH T ss_pred CCCCEEEEEeCCCCC------------hhHHHHHHHHHHHHHHc--------CCeEE--EEECC-CH----HHHHHHHHH Confidence 467889999886432 24556667777666553 22332 33322 11 122233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++|++|...... .+...++|+|..+...+. +....+..++... T Consensus 115 l~~-------------------~~~d~ii~~~~~~-------~~~~~~ipvv~~~~~~~~-------~~~~~v~~d~~~~ 161 (333) T 3JVD_A 115 LIS-------------------IQAAGIIHVPVVG-------SIAPEGIPMVQLTRGELG-------PGFPRVLCDDEAG 161 (333) T ss_dssp HHH-------------------HTCSEEEECCCTT-------CCC-CCSCEEEECC-----------CCSCEEEECHHHH T ss_pred HHh-------------------cCCCEEEEecccc-------cccCCCCCEEEEcCCCCC-------CCCCEEEeCcHHH Confidence 332 4778887643221 356679999987764321 2345666666667 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) +..+++++.+.++++++++.... .....+.++|++.+++. ++.+..... . .+..+....++.+++..++|++++ T Consensus 162 ~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~-~--~~~~~~~~~~~~~~~~~~~dai~~ 237 (333) T 3JVD_A 162 FFQLTESVLGGSGMNIAALVGEESLSTTQERMRGISHAASIY-GAEVTFHFG-H--YSVESGEEMAQVVFNNGLPDALIV 237 (333) T ss_dssp HHHHHHHHCCSSSCEEEEEESCTTSHHHHHHHHHHHHHHHHT-TCEEEEEEC-C--SSHHHHHHHHHHHHHTCCCSEEEE T ss_pred HHHHHHHHHcCCCCcEEEEECCcccchHHHHHHHHHHHHHHc-CCccEEEec-C--CCHHHHHHHHHHHHhCCCCCEEEE Confidence 77778887655788999887532 44566778888888775 344432100 0 111122334444432235778665 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~ 299 (908) .. +..+..+++++++.|+ T Consensus 238 ~~-d~~a~~~~~al~~~g~ 255 (333) T 3JVD_A 238 AS-PRLMAGVMRAFTRLNV 255 (333) T ss_dssp CC-HHHHHHHHHHHHHTTC T ss_pred CC-HHHHHHHHHHHHHCCC Confidence 53 5556678888888776 No 301 >3JVD_B Transcriptional regulators; STRUCTURAL GENOMICS, PSI-2, SUGAR BINDING; HET: SO4; 2.3A {Corynebacterium glutamicum} Probab=95.72 E-value=0.00012 Score=74.15 Aligned_cols=192 Identities=13% Similarity=0.121 Sum_probs=106.7 Template_Neff=11.400 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .+..+||++.|..+. .++..+..+++.++++. |+++. +.+.. ++ +...+.+++ T Consensus 62 ~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~~~--~~~~~-~~----~~~~~~~~~ 114 (333) T 3JVD_B 62 HRSALVGVIVPDLSN------------EYYSESLQTIQQDLKAA--------GYQML--VAEAN-SV----QAQDVVMES 114 (333) T ss_dssp --CCEEEEEESCTTC------------HHHHTTHHHHHHHHHHT--------TCEEE--EEECC-SH----HHHHHHHHH T ss_pred CCCCEEEEEeCCCCC------------hhHHHHHHHHHHHHHHc--------CCeEE--EEECC-CH----HHHHHHHHH Confidence 467889999886432 24556667777666553 22332 33322 11 122233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++|++|...... .+...++|+|..+...+. +....+..++... T Consensus 115 l~~-------------------~~~d~ii~~~~~~-------~~~~~~ipvv~~~~~~~~-------~~~~~v~~d~~~~ 161 (333) T 3JVD_B 115 LIS-------------------IQAAGIIHVPVVG-------SIAPEGIPMVQLTRGELG-------PGFPRVLCDDEAG 161 (333) T ss_dssp HHH-------------------TTCSEEEECCC-----------CCSSSCEEEESSCCCB-------TTBCEEEECHHHH T ss_pred HHh-------------------cCCCEEEEecccc-------cccCCCCCEEEEcCCCCC-------CCCCEEEeCcHHH Confidence 332 4778887643221 356679999987764321 2345666666667 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) +..+++++.+.++++++++.... .....+.++|++.+++. ++.+..... . .+..+....++.+++..++|++++ T Consensus 162 ~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~-~--~~~~~~~~~~~~~~~~~~~dai~~ 237 (333) T 3JVD_B 162 FFQLTESVLGGSGMNIAALVGEESLSTTQERMRGISHAASIY-GAEVTFHFG-H--YSVESGEEMAQVVFNNGLPDALIV 237 (333) T ss_dssp HHHHHHHHCCSSSCEEEEEESCTTSHHHHHHHHHHHHHHHHT-TCEEEEEEC-C--SSHHHHHHHHHHHHHTCCCSEEEE T ss_pred HHHHHHHHHcCCCCcEEEEECCcccchHHHHHHHHHHHHHHc-CCccEEEec-C--CCHHHHHHHHHHHHhCCCCCEEEE Confidence 77778887655788999887532 44566778888888775 344432100 0 111122334444432235778665 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~ 299 (908) .. +..+..+++++++.|+ T Consensus 238 ~~-d~~a~~~~~al~~~g~ 255 (333) T 3JVD_B 238 AS-PRLMAGVMRAFTRLNV 255 (333) T ss_dssp CC-HHHHHHHHHHHHHTTC T ss_pred CC-HHHHHHHHHHHHHCCC Confidence 53 5556678888888776 No 302 >3S99_A Basic membrane lipoprotein; SSGCID, Basic membrane lipoprotein, Structural; HET: IOD, ADE; 2.05A {Brucella melitensis biovar Abortus} Probab=95.68 E-value=0.00014 Score=74.71 Aligned_cols=216 Identities=7% Similarity=-0.005 Sum_probs=102.9 Template_Neff=10.300 Q NP_000836.2 27 MMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC 106 (908) Q Consensus 27 ~~~~~~~~~~~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~ 106 (908) ||...+ ...+......+..+||++.|..... ..+......+++.++++. |+.+++.+.+.. T Consensus 9 ~~~~~~-~~~~~~~~~~~~~~I~~v~~~~~~d----------~~~~~~~~~g~~~~~~~~--------g~~v~~~~~~~~ 69 (356) T 3S99_A 9 MGTLEA-QTQGPGSMAEEKLKVGFIYIGPPGD----------FGWTYQHDQARKELVEAL--------GDKVETTFLENV 69 (356) T ss_dssp ------------------CEEEEEECSSCGGG----------SSHHHHHHHHHHHHHHHH--------TTTEEEEEECSC T ss_pred cccccc-cCCCCCCccccccEEEEEEccCCCc----------cchHHHHHHHHHHHHHHH--------CCCeEEEEEecC Confidence 444333 3334446667889999999753210 024456667777666653 232344444432 Q NP_000836.2 107 SRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILR-LFKIPQISYASTAPELSD 185 (908) Q Consensus 107 ~~~~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~-~~~iP~Is~~~~~~~l~~ 185 (908) .+. ....+.+++++. .++|+||+...... ..+..+++ ..++|++..+...+ T Consensus 70 ~~~----~~~~~~i~~~~~-------------------~~~d~II~~~~~~~-~~~~~~~~~~~~ip~v~~~~~~~---- 121 (356) T 3S99_A 70 AEG----ADAERSIKRIAR-------------------AGNKLIFTTSFGYM-DPTVKVAKKFPDVKFEHATGYKT---- 121 (356) T ss_dssp CTT----HHHHHHHHHHHH-------------------TTCSEEEECSGGGH-HHHHHHHTTCTTSEEEEESCCCC---- T ss_pred CCh----hhHHHHHHHHHH-------------------cCCCEEEEcChhhh-HHHHHHHHHCCCCEEEEccCCCC---- Confidence 221 122233333332 57888886543322 22223333 36899888765332 Q NP_000836.2 186 NTRYDFFSRVVPPDSYQAQAMVDIVTA-LGWNYVSTLASEG-NYGESGVEAFTQISREIG-GVCIAQSQKIPREP-RPGE 261 (908) Q Consensus 186 ~~~~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v~ii~~~~-~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~-~~~~ 261 (908) .+++..+..+....+..++.++.. .+.++|+++.... .....+.++|.+.+++.+ .+.+... +..+. +... T Consensus 122 ---~~n~~~v~~d~~~~~~~ag~~~~~~~~~~~i~~i~~~~~~~~~~~~~gf~~~~~~~~~~~~~~~~--~~~~~~d~~~ 196 (356) T 3S99_A 122 ---ADNMSAYNARFYEGRYVQGVIAAKMSKKGIAGYIGSVPVPEVVQGINSFMLGAQSVNPDFRVKVI--WVNSWFDPGK 196 (356) T ss_dssp ---BTTEEEEEECHHHHHHHHHHHHHHHCSSCEEEEEECCCCHHHHHHHHHHHHHHHTTCTTCEEEEE--ECSSSCCHHH T ss_pred ---CCCeEEEeeehHHHHHHHHHHHHHHcCCCeeEEEeCCCChHHhhhHHHHHHHHHHhCCCCEEEEE--EcCCCCChhH Confidence 134455556655566666665543 4667899887432 334566777777776532 1222111 11001 1112 Q NP_000836.2 262 FEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 262 ~~~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g 298 (908) ..+.+++++. .++|+|+...+ +..+++++++.+ T Consensus 197 ~~~~~~~ll~-~~~d~I~~~~~---a~~v~~a~~~~g 229 (356) T 3S99_A 197 EADAAKALID-QGVDIITQHTD---STAAIQVAHDRG 229 (356) T ss_dssp HHHHHHHHHH-TTCSEEEESSS---SSHHHHHHHHTT T ss_pred HHHHHHHHHH-CCCCEEEeCCC---CHHHHHHHHHcC Confidence 2344555553 47888877653 456777776654 No 303 >6DSP_B Autoinducer 2-binding protein LsrB; AI-2 receptor, SIGNALING PROTEIN; HET: PAV; 1.37A {Clostridium saccharobutylicum DSM 13864} Probab=95.34 E-value=0.00028 Score=71.90 Aligned_cols=221 Identities=6% Similarity=-0.041 Sum_probs=98.5 Template_Neff=11.100 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ......+..+||++.+.... .+...+..+++.++++. |+++.+.. +...++ .... T Consensus 14 ~~~~~~~~~~Igvi~~~~~~------------~~~~~~~~g~~~~a~~~--------g~~~~~~~-~~~~~~----~~~~ 68 (347) T 6DSP_B 14 TNSSKKGNVTVTFIPKLTGN------------AFFESANKGAQKYSEQW--------GFKVDYEG-DANASA----ASQV 68 (347) T ss_dssp --------CEEEEECSCSSS------------HHHHHHHHHHHHHHHHH--------TCEEEECC-CSSCCH----HHHH T ss_pred cCccCCCCeEEEEEecCCCC------------HHHHHHHHHHHHHHHHH--------CCEEEEEc-CCCCCH----HHHH Confidence 34566778999999875332 24456667777666653 23333321 222221 1222 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +.+++++. +++|++|....... .......+...++|+|.++...+. .....+.+. T Consensus 69 ~~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~ 124 (347) T 6DSP_B 69 SVINKAVQ-------------------QGTNAICLSSVDAAGVKDALKAAADAGVTVTTWDSDVDP-----SVRKVMVSQ 124 (347) T ss_dssp HHHHHHHH-------------------TTCSEEEECCSCHHHHHHHHHHHHHTTCEEEEESSCCCG-----GGCSEEEES T ss_pred HHHHHHHH-------------------cCCCEEEEeCCChHHHHHHHHHHHHCCCEEEEECCCCCc-----ccceeEEee Confidence 33443332 47888776433222 223445566789999988754321 011233444 Q NP_000836.2 197 PPDSYQAQAMVDIVTALGWN------YVST--LAS-EG-N---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFE 263 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~~~~~------~v~i--i~~-~~-~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~ 263 (908) .++...++.+++++.+.+.+ ++++ +.. .. . ....+...++...++..++.+.....+....+..+.. T Consensus 125 ~d~~~~g~~~~~~l~~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 204 (347) T 6DSP_B 125 GTPEQLGQMLVQMGYDSLKERGKDPEKDAIKYCWHYSNATVTDQNSWQVEGEKYIKSKYPNWQNVAPDNYYSNQDAEQAI 204 (347) T ss_dssp CCHHHHHHHHHHHHHHHHHHTTCCTTTSCCEEEEEESCSSCHHHHHHHHHHHHHHHHHCTTCEESCTTCEECTTCHHHHH T ss_pred CCHHHHHHHHHHHHHHHHHhcCCCcccccceEEEEecCCCcchHHHHHHHHHHHHHHHCCCcEEccCCCCCCCCCHHHHH Confidence 55666677777776443322 3333 221 11 1 1112333343333322123322111001001112233 Q NP_000836.2 264 KIIKRLLET-PNARAVIMFANEDDIRRILEAAKKLNQS-GHFLWIGS 308 (908) Q Consensus 264 ~~~~~l~~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~-~~~~~i~~ 308 (908) ..++++++. .++++|++. ++..+..+++++++.|+. .++.+++. T Consensus 205 ~~~~~~l~~~~~~dai~~~-~d~~a~~~~~al~~~g~~p~~v~v~g~ 250 (347) T 6DSP_B 205 SVGESILSAHSDIDLIICN-DSTALPGQAQAAQNKGLTAKNVTITGF 250 (347) T ss_dssp HHHHHHHHHCTTCCEEEEC-STTHHHHHHHHHHHTTCCTTTCEEEEB T ss_pred HHHHHHHHHCCCcCEEEEc-CCCchHHHHHHHHHCCCCCCCeEEEeC Confidence 445555431 246777663 444556778888887764 23444443 No 304 >2FQW_A Membrane lipoprotein tmpC; ABC transport system, ligand-binding protein; HET: NOS; 1.71A {Treponema pallidum} Probab=95.31 E-value=0.0003 Score=70.64 Aligned_cols=146 Identities=10% Similarity=0.046 Sum_probs=74.4 Template_Neff=11.200 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANIL-RLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAM----VDIVTALGWNYVS 219 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~-~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~----~~~l~~~~~~~v~ 219 (908) +++++||+...... .....++ +..++|++..+...+. .+++..+..+....+..+ ++++.+.+.++++ T Consensus 61 ~~~d~Ii~~~~~~~-~~~~~~~~~~~~i~~v~~~~~~~~------~~~~~~v~~~~~~~~~~~g~~a~~~~~~~g~~~i~ 133 (318) T 2FQW_A 61 ENMGLVVACGSFLV-EAVIETSARFPKQKFLVIDAVVQD------RDNVVSAVFGQNEGSFLVGVAAALKAKEAGKSAVG 133 (318) T ss_dssp TTCSEEEEESGGGH-HHHHHHHHHCTTSCEEEESSCCCS------CTTEEEEEECHHHHHHHHHHHHHHHHHHTTCCEEE T ss_pred CCCCEEEEcCHHHH-HHHHHHHHHCCCCeEEEEeccCCC------cccEEEEeechhHHHHHHHHHHHHHHHHcCCCEEE Confidence 47888886543322 1222222 3458998887654321 122333334433333333 4455445678999 Q NP_000836.2 220 TLASEG-NYGESGVEAFTQISREIGGVCIAQSQKIPREP-RPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKL 297 (908) Q Consensus 220 ii~~~~-~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~ 297 (908) ++.... .....+.++|++.+++.+ ..+.....+..+. +.....+.++++.. .++|+|+... +..+..+++++++. T Consensus 134 ~i~~~~~~~~~~~~~gf~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~d~i~~~~-~~~~~~~~~a~~~~ 210 (318) T 2FQW_A 134 FIVGMELGMMPLFEAGFEAGVKAVD-PDIQVVVEVANTFSDPQKGQALAAKLYD-SGVNVIFQVA-GGTGNGVIKEARDR 210 (318) T ss_dssp EEESCCSTTTHHHHHHHHHHHHHHC-TTCEEEEEECSCSSCHHHHHHHHHHHHH-TTCCEEEEEC-GGGHHHHHHHHHHH T ss_pred EEecccCcchhHHHHHHHHHHHHHC-CCCEEEEEEcCCCCCHHHHHHHHHHHHH-cCCCEEEEcC-cHHhHHHHHHHHHh Confidence 998432 344556677777776532 2211111111001 11123344555553 4788887764 33455677888777 Q NP_000836.2 298 NQS 300 (908) Q Consensus 298 g~~ 300 (908) |+. T Consensus 211 g~~ 213 (318) T 2FQW_A 211 RLN 213 (318) T ss_dssp HHT T ss_pred hcC Confidence 653 No 305 >2FQX_A Membrane lipoprotein tmpC; ABC transport system, ligand-binding protein; HET: GMP; 1.7A {Treponema pallidum} Probab=95.31 E-value=0.0003 Score=70.64 Aligned_cols=146 Identities=10% Similarity=0.046 Sum_probs=74.4 Template_Neff=11.200 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANIL-RLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAM----VDIVTALGWNYVS 219 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~-~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~----~~~l~~~~~~~v~ 219 (908) +++++||+...... .....++ +..++|++..+...+. .+++..+..+....+..+ ++++.+.+.++++ T Consensus 61 ~~~d~Ii~~~~~~~-~~~~~~~~~~~~i~~v~~~~~~~~------~~~~~~v~~~~~~~~~~~g~~a~~~~~~~g~~~i~ 133 (318) T 2FQX_A 61 ENMGLVVACGSFLV-EAVIETSARFPKQKFLVIDAVVQD------RDNVVSAVFGQNEGSFLVGVAAALKAKEAGKSAVG 133 (318) T ss_dssp TTCSEEEEESTTTH-HHHHHHHHHCTTSCEEEESSCCCS------CTTEEEEEECHHHHHHHHHHHHHHHHHHTTCCEEE T ss_pred CCCCEEEEcCHHHH-HHHHHHHHHCCCCeEEEEeccCCC------cccEEEEeechhHHHHHHHHHHHHHHHHcCCCEEE Confidence 47888886543322 1222222 3458998887654321 122333334433333333 4455445678999 Q NP_000836.2 220 TLASEG-NYGESGVEAFTQISREIGGVCIAQSQKIPREP-RPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKL 297 (908) Q Consensus 220 ii~~~~-~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~ 297 (908) ++.... .....+.++|++.+++.+ ..+.....+..+. +.....+.++++.. .++|+|+... +..+..+++++++. T Consensus 134 ~i~~~~~~~~~~~~~gf~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~d~i~~~~-~~~~~~~~~a~~~~ 210 (318) T 2FQX_A 134 FIVGMELGMMPLFEAGFEAGVKAVD-PDIQVVVEVANTFSDPQKGQALAAKLYD-SGVNVIFQVA-GGTGNGVIKEARDR 210 (318) T ss_dssp EEESCCSTTTHHHHHHHHHHHHHHC-TTCEEEEEECSCSSCHHHHHHHHHHHHH-TTCCEEEEEC-GGGHHHHHHHHHHH T ss_pred EEecccCcchhHHHHHHHHHHHHHC-CCCEEEEEEcCCCCCHHHHHHHHHHHHH-cCCCEEEEcC-cHHhHHHHHHHHHh Confidence 998432 344556677777776532 2211111111001 11123344555553 4788887764 33455677888777 Q NP_000836.2 298 NQS 300 (908) Q Consensus 298 g~~ 300 (908) |+. T Consensus 211 g~~ 213 (318) T 2FQX_A 211 RLN 213 (318) T ss_dssp HHT T ss_pred hcC Confidence 653 No 306 >2FQY_A Membrane lipoprotein tmpC; ABC receptor protein, nucleoside binding; HET: ADN; 1.9A {Treponema pallidum} Probab=95.31 E-value=0.0003 Score=70.64 Aligned_cols=146 Identities=10% Similarity=0.046 Sum_probs=74.4 Template_Neff=11.200 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANIL-RLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAM----VDIVTALGWNYVS 219 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~-~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~----~~~l~~~~~~~v~ 219 (908) +++++||+...... .....++ +..++|++..+...+. .+++..+..+....+..+ ++++.+.+.++++ T Consensus 61 ~~~d~Ii~~~~~~~-~~~~~~~~~~~~i~~v~~~~~~~~------~~~~~~v~~~~~~~~~~~g~~a~~~~~~~g~~~i~ 133 (318) T 2FQY_A 61 ENMGLVVACGSFLV-EAVIETSARFPKQKFLVIDAVVQD------RDNVVSAVFGQNEGSFLVGVAAALKAKEAGKSAVG 133 (318) T ss_dssp TTCSEEEEESGGGH-HHHHHHHHHCTTSCEEEESSCCCS------CTTEEEEEECHHHHHHHHHHHHHHHHHHTTCSEEE T ss_pred CCCCEEEEcCHHHH-HHHHHHHHHCCCCeEEEEeccCCC------cccEEEEeechhHHHHHHHHHHHHHHHHcCCCEEE Confidence 47888886543322 1222222 3458998887654321 122333334433333333 4455445678999 Q NP_000836.2 220 TLASEG-NYGESGVEAFTQISREIGGVCIAQSQKIPREP-RPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKL 297 (908) Q Consensus 220 ii~~~~-~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~ 297 (908) ++.... .....+.++|++.+++.+ ..+.....+..+. +.....+.++++.. .++|+|+... +..+..+++++++. T Consensus 134 ~i~~~~~~~~~~~~~gf~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~d~i~~~~-~~~~~~~~~a~~~~ 210 (318) T 2FQY_A 134 FIVGMELGMMPLFEAGFEAGVKAVD-PDIQVVVEVANTFSDPQKGQALAAKLYD-SGVNVIFQVA-GGTGNGVIKEARDR 210 (318) T ss_dssp EEESCCSTTTHHHHHHHHHHHHHHC-TTCEEEEEECSCSSCHHHHHHHHHHHHH-TTCCEEEEEC-HHHHHHHHHHHHHH T ss_pred EEecccCcchhHHHHHHHHHHHHHC-CCCEEEEEEcCCCCCHHHHHHHHHHHHH-cCCCEEEEcC-cHHhHHHHHHHHHh Confidence 998432 344556677777776532 2211111111001 11123344555553 4788887764 33455677888777 Q NP_000836.2 298 NQS 300 (908) Q Consensus 298 g~~ 300 (908) |+. T Consensus 211 g~~ 213 (318) T 2FQY_A 211 RLN 213 (318) T ss_dssp HHT T ss_pred hcC Confidence 653 No 307 >3H5T_A Transcriptional regulator, LacI family; Transcriptional regulator, DNA-dependent, Protein Structure; 2.53A {Corynebacterium glutamicum} Probab=95.00 E-value=0.00053 Score=70.44 Aligned_cols=146 Identities=15% Similarity=0.125 Sum_probs=82.3 Template_Neff=10.800 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++|++|....... ......+...++|+|..+...+ .+.+..+..++...++.+++++.+.+.++|+++... T Consensus 127 ~~~dgii~~~~~~~-~~~~~~~~~~~ipvV~~~~~~~-------~~~~~~v~~d~~~~g~~~~~~l~~~g~~~i~~i~~~ 198 (366) T 3H5T_A 127 AAVDGVVIYSVAKG-DPHIDAIRARGLPAVIADQPAR-------EEGMPFIAPNNRKAIAPAAQALIDAGHRKIGILSIR 198 (366) T ss_dssp CCCSCEEEESCCTT-CHHHHHHHHHTCCEEEESSCCS-------CTTCCEEEECHHHHTHHHHHHHHHTTCCSEEEEEEC T ss_pred CCCCEEEEEccCCC-ChHHHHHHHcCCCEEEeCCCcc-------cCCCCEEecChHHHHHHHHHHHHHCCCCcEEEEeCC Confidence 47787775433322 2333455667999998875432 123445556667778888888876688899998743 Q NP_000836.2 225 G-------------------NYGESGVEAFTQISREIGGVCIAQSQKIPRE-PRPGEFEKIIKRLLE-TPNARAVIMFAN 283 (908) Q Consensus 225 ~-------------------~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~-~~~~~~~~~~~~l~~-~~~~~viv~~~~ 283 (908) . .....+.+++.+.+++. ++.+......... .+..+....++++++ ..++++|++.. T Consensus 199 ~~~~~~~~~~~~~~~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~ai~~~~- 276 (366) T 3H5T_A 199 LDRANNDGEVTRERLENAQYQVQRDRVRGAMEVFIEA-GIDPGTVPIMECWINNRQHNFEVAKELLETHPDLTAVLCTV- 276 (366) T ss_dssp CSSSCCCEECCHHHHHTCCCTTHHHHHHHHHHHHHHH-TCCGGGSCEEEESSCCHHHHHHHHHHHHHHCTTCCEEEESS- T ss_pred ccccCCCCccchHHHHhhchHHHHHHHHHHHHHHHHC-CCCCCCCccccccccchhhHHHHHHHHHHhCCCccEEEECC- Confidence 2 23445667777777664 3433211111000 011123334444442 12467776654 Q NP_000836.2 284 EDDIRRILEAAKKLNQS 300 (908) Q Consensus 284 ~~~~~~~l~~~~~~g~~ 300 (908) +..+..+++++.+.|+. T Consensus 277 d~~a~~~~~al~~~g~~ 293 (366) T 3H5T_A 277 DALAFGVLEYLKSVGKS 293 (366) T ss_dssp HHHHHHHHHHHHHTTCC T ss_pred HHHHHHHHHHHHHcCCC Confidence 44566777888777764 No 308 >6NDI_A Hypothetical Protein CD630_05490; Structural Genomics, Center for Structural; HET: MSE; 2.6A {Klebsiella pneumoniae subsp. pneumoniae} Probab=94.87 E-value=0.00064 Score=68.56 Aligned_cols=144 Identities=12% Similarity=0.080 Sum_probs=79.7 Template_Neff=11.600 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++|++|........... ..+..++|+|..+...+ .+....+..++...++.+++++.+.+.++++++... T Consensus 119 ~~~d~ii~~~~~~~~~~~--~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~~g~~~~~~l~~~g~~~i~~i~~~ 189 (334) T 6NDI_A 119 HRPDGIIFTTMGLRQVPL--PEKLLTLPCVLANCESL-------SQPVASYIPDDEQGQYDAVKALLAAGYRRPLCLHLP 189 (334) T ss_dssp TCCSEEEEEEEEEECCCS--CGGGSSSCSEEEEECCS-------SSCCEEEEECHHHHHHHHHHHHHHTTCCCEEEEECC T ss_pred cCCCEEEEeCCCCCCCCC--chHHcCCCEEEEcCCcc-------CCCceEEEcCCHHHHHHHHHHHHHCCCCcEEEEeCC Confidence 478877764332222221 22347999988765432 123455666777778888888766788899998843 Q NP_000836.2 225 G--NYGESGVEAFTQISREIGGVCIAQSQ--KIP-REPRPG-EFEKIIKRLLE-TPNARAVIMFANEDDIRRILEAAKKL 297 (908) Q Consensus 225 ~--~~~~~~~~~~~~~~~~~~~i~v~~~~--~~~-~~~~~~-~~~~~~~~l~~-~~~~~viv~~~~~~~~~~~l~~~~~~ 297 (908) . .....+.++|++.+++. ++.+.... ... .+.... ......+.+++ ..++++|++.. +..+..+++++++. T Consensus 190 ~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ai~~~~-d~~a~~~~~~l~~~ 267 (334) T 6NDI_A 190 ASQPATIRRRRGLERACREA-GIEPDHLSHSYMGQGDEHYHDIPAVVLAHIREGKPGFDSVICGN-DRIAFMVYQTLLGQ 267 (334) T ss_dssp TTSHHHHHHHHHHHHHHHHT-TCCGGGSCEEECCSSGGGGGGHHHHHHHTEETTEESCSEEEESS-HHHHHHHHHHHHHT T ss_pred CCChHHHHHHHHHHHHHHHc-CCCcccccccccCCCCcccccHHHHHHHHHHhCCCCCcEEEECC-HHHHHHHHHHHHHC Confidence 2 24556777888887765 34332110 000 000011 11122233322 13567776653 44566788888887 Q NP_000836.2 298 NQ 299 (908) Q Consensus 298 g~ 299 (908) |+ T Consensus 268 g~ 269 (334) T 6NDI_A 268 GL 269 (334) T ss_dssp TC T ss_pred CC Confidence 76 No 309 >6NDI_B Hypothetical Protein CD630_05490; Structural Genomics, Center for Structural; HET: MSE; 2.6A {Klebsiella pneumoniae subsp. pneumoniae} Probab=94.87 E-value=0.00064 Score=68.56 Aligned_cols=144 Identities=12% Similarity=0.080 Sum_probs=79.7 Template_Neff=11.600 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++|++|........... ..+..++|+|..+...+ .+....+..++...++.+++++.+.+.++++++... T Consensus 119 ~~~d~ii~~~~~~~~~~~--~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~~g~~~~~~l~~~g~~~i~~i~~~ 189 (334) T 6NDI_B 119 HRPDGIIFTTMGLRQVPL--PEKLLTLPCVLANCESL-------SQPVASYIPDDEQGQYDAVKALLAAGYRRPLCLHLP 189 (334) T ss_dssp TCCSEEEEEEEEEECCCS--CGGGSSSCSEEEEECCS-------SSCCEEEEECHHHHHHHHHHHHHHTTCCCEEEEECC T ss_pred cCCCEEEEeCCCCCCCCC--chHHcCCCEEEEcCCcc-------CCCceEEEcCCHHHHHHHHHHHHHCCCCcEEEEeCC Confidence 478877764332222221 22347999988765432 123455666777778888888766788899998843 Q NP_000836.2 225 G--NYGESGVEAFTQISREIGGVCIAQSQ--KIP-REPRPG-EFEKIIKRLLE-TPNARAVIMFANEDDIRRILEAAKKL 297 (908) Q Consensus 225 ~--~~~~~~~~~~~~~~~~~~~i~v~~~~--~~~-~~~~~~-~~~~~~~~l~~-~~~~~viv~~~~~~~~~~~l~~~~~~ 297 (908) . .....+.++|++.+++. ++.+.... ... .+.... ......+.+++ ..++++|++.. +..+..+++++++. T Consensus 190 ~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ai~~~~-d~~a~~~~~~l~~~ 267 (334) T 6NDI_B 190 ASQPATIRRRRGLERACREA-GIEPDHLSHSYMGQGDEHYHDIPAVVLAHIREGKPGFDSVICGN-DRIAFMVYQTLLGQ 267 (334) T ss_dssp TTSHHHHHHHHHHHHHHHHT-TCCGGGSCEEECCSSGGGGGGHHHHHHHTEETTEESCSEEEESS-HHHHHHHHHHHHHT T ss_pred CCChHHHHHHHHHHHHHHHc-CCCcccccccccCCCCcccccHHHHHHHHHHhCCCCCcEEEECC-HHHHHHHHHHHHHC Confidence 2 24556777888887765 34332110 000 000011 11122233322 13567776653 44566788888887 Q NP_000836.2 298 NQ 299 (908) Q Consensus 298 g~ 299 (908) |+ T Consensus 268 g~ 269 (334) T 6NDI_B 268 GL 269 (334) T ss_dssp TC T ss_pred CC Confidence 76 No 310 >4IIL_A Membrane lipoprotein TpN38(b); periplasmic-binding protein, riboflavin transport, MEMBRANE; HET: EDO, RBF; 1.3A {Treponema pallidum subsp. pallidum} Probab=94.79 E-value=0.00072 Score=68.72 Aligned_cols=212 Identities=10% Similarity=0.067 Sum_probs=105.5 Template_Neff=10.600 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++.+||++.|..... ..+......+++.++++.|..+ .++.+ .+.+...+. +...+. T Consensus 27 ~~~~~~~~I~~i~~~~~~~----------~~~~~~~~~gi~~~~~~~~~~g---~~~~~--~~~~~~~~~----~~~~~~ 87 (346) T 4IIL_A 27 VQDERAVRIAVFVPGFRHD----------SPVYAMLCDGVERAVTQERATG---RSIGL--DIIEAGPNQ----ALWREK 87 (346) T ss_dssp ----CCEEEEEEESSCSTT----------CHHHHHHHHHHHHHHHHHHTTT---CCEEE--EEEECCSCG----GGHHHH T ss_pred CCCccCceEEEEeCCCCCC----------ChHHHHHHHHHHHHHHHHHhcc---ccccc--EEEEcCCCH----HHHHHH Confidence 4456789999999764211 1255677788888888765321 12233 333332121 122333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANIL-RLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~-~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. .+++|+||+...... .....++ ...++|+|..+...+. .+.+..+..+ T Consensus 88 l~~~~~------------------~~~~d~Ii~~~~~~~-~~~~~~~~~~~~i~~v~~~~~~~~------~~~~~~v~~d 142 (346) T 4IIL_A 88 LAHLAA------------------EQRYRLIVSSNPALP-HVLEPILRQFPLQRFLVLDAYAPQ------EHSLITFRYN 142 (346) T ss_dssp HHHHHH------------------TTCCSEEEEESTTHH-HHHHHHHHHCTTCCEEEESCCCTT------CSSEEEEEEC T ss_pred HHHHHH------------------hCCCCEEEEcChhhH-HHHHHHHHHCCCCEEEEEeCCCCC------CCcEEEEEEc Confidence 333321 157888886543222 2222232 3568998887654321 1233444455 Q NP_000836.2 199 DSYQAQAMVDIVTA---------LGWNYVSTLASEGN-YGESG-VEAFTQISREIG-GVCIAQSQKIPREP-RPGEFEKI 265 (908) Q Consensus 199 ~~~~~~~~~~~l~~---------~~~~~v~ii~~~~~-~~~~~-~~~~~~~~~~~~-~i~v~~~~~~~~~~-~~~~~~~~ 265 (908) ....+..++.++.. .+.++|+++..... ....+ .++|++.+++.+ .+++... +..+. +.....+. T Consensus 143 ~~~~~~~ag~~~~~~~~~~~~~~~g~~~i~~i~~~~~~~~~~r~~~gf~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~ 220 (346) T 4IIL_A 143 QWEQAYLAGHLSALVSASAMRFANADKKIGLIAGQSYPVMTQTIIPAFLAGARAVDPAFEVDVR--VVGNWYDAAKSADL 220 (346) T ss_dssp HHHHHHHHHHHHHHHHHSCCTTCCSSCEEEEEESSCCHHCCCCCHHHHHHHHHHHCTTCEEEEE--ECSSSSCHHHHHHH T ss_pred HHHHHHHHHHHHHHHhhhHhhhhcCCCEEEEEeCcCCcchhhhHHHHHHHHHHHhCCCCEEEEE--EecCCCCHHHHHHH Confidence 55455554444422 25678998885432 22233 677777776531 1222111 11001 11223445 Q NP_000836.2 266 IKRLLETPNARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 266 ~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) ++++.. .++|+|+... +..+..+++++++.|. T Consensus 221 ~~~l~~-~~~d~i~~~~-~~~a~gv~~a~~~~gv 252 (346) T 4IIL_A 221 ARILFH-EGVDVMMPIC-GGANQGVLAAARELGF 252 (346) T ss_dssp HHHHHH-HTCCEEEEEC-GGGHHHHHHHCCCCCC T ss_pred HHHHHH-CCCCEEEECC-chhhHHHHHHHHHhCC Confidence 555553 4788887764 4445667777776653 No 311 >6PI6_C Atrazine periplasmic binding protein; SAD phasing, periplasmic binding protein; HET: OKM; 1.65A {Pseudomonas sp. (strain ADP)} Probab=94.78 E-value=0.00074 Score=68.92 Aligned_cols=206 Identities=6% Similarity=-0.033 Sum_probs=104.7 Template_Neff=10.200 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ......+..+||+++|..... ..+......+++.++++.+ +.+.+.+.+...++ .... T Consensus 17 ~~~~~~~~~~I~~v~~~~~~d----------~~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~~~~~----~~~~ 74 (355) T 6PI6_C 17 RGSHMQEPLKVAFVYAGPVSD----------AGYTYAHDQGRLAMEKNLG--------AKVKSSYVENVPEG----ADAE 74 (355) T ss_dssp ------CCEEEEEECSSCGGG----------SSHHHHHHHHHHHHHHHHG--------GGEEEEEECSCCSG----GGHH T ss_pred CCCCCCCCeEEEEEEccCCCc----------cchHHHHHHHHHHHHHHhC--------CCcEEEEEecCCCc----ccHH Confidence 344566789999999864211 1245667777777777653 33443333322221 1222 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRL-FKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~-~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +.+++++. .++|+||+...... ..+..++++ .++|+|..+...+ .+++..+. T Consensus 75 ~~l~~l~~-------------------~~~d~II~~~~~~~-~~~~~~a~~~~~i~~v~~~~~~~-------~~~~~~v~ 127 (355) T 6PI6_C 75 RVIRKLAA-------------------DGNKLIFTTSFGFM-NPTERVAKAFPNVVFEHATGVKL-------AKNLGVYE 127 (355) T ss_dssp HHHHHHHH-------------------TTCSEEEECSGGGH-HHHHHHHHHCTTSEEEEETCCCC-------BTTEEEEE T ss_pred HHHHHHHH-------------------CCCCEEEEcChhhH-HHHHHHHHHCCCCEEEEcccCCC-------cCCEEEec Confidence 33333332 46788876543322 223333433 6899988765432 12344555 Q NP_000836.2 197 PPDSYQAQAMVDIVTA-LGWNYVSTLASE-GNYGESGVEAFTQISREIG-GVCIAQSQKIPREP-RPGEFEKIIKRLLET 272 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~-~~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~ 272 (908) .+....+..++.++.. .+.++|+++... ......+.++|.+.+++.+ .+.+... +.... +.....+.+++++. T Consensus 128 ~d~~~~g~~ag~~a~~~~~~~~i~~i~~~~~~~~~~~~~gf~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~ll~- 204 (355) T 6PI6_C 128 SRQYEGTYLQGVLAAKMTKTGVIGFVGSFPVPEVIRNINAYTLGAQSVNPKIKTKVI--WVSTWYDPAKERQAAETLIA- 204 (355) T ss_dssp ECTHHHHHHHHHHHHHHCSSSEEEEEESCCSHHHHHHHHHHHHHHHTTCTTCEEEEE--ECSCSCCHHHHHHHHHHHHH- T ss_pred cchHHHHHHHHHHHHHHcCCCcEEEEeCCCchHHHHHHHHHHHHHHHhCCCCEEEEE--EccCCCCHHHHHHHHHHHHH- Confidence 5665566655555443 356789988743 2344566777877776532 1222111 11001 11122344555553 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g 298 (908) .++|+|+...+ +..+++++++.| T Consensus 205 ~~~d~I~~~~~---a~gv~~a~~~~g 227 (355) T 6PI6_C 205 QGADVLTQNTN---SPATLQVAQEKG 227 (355) T ss_dssp TTCCEEEESSS---SSHHHHHHHHTT T ss_pred CCCCEEEeCCC---CHHHHHHHHHhC Confidence 47888877653 356677776655 No 312 >6PII_A Atrazine periplasmic binding protein; SAD phasing, periplasmic binding protein; HET: EMC, GUN, PO4; 1.87A {Pseudomonas sp. (strain ADP)} Probab=94.78 E-value=0.00074 Score=68.92 Aligned_cols=206 Identities=6% Similarity=-0.033 Sum_probs=106.5 Template_Neff=10.200 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ......+..+||+++|..... ..+......+++.++++.+ +.+.+.+.+...++ .... T Consensus 17 ~~~~~~~~~~I~~v~~~~~~d----------~~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~~~~~----~~~~ 74 (355) T 6PII_A 17 RGSHMQEPLKVAFVYAGPVSD----------AGYTYAHDQGRLAMEKNLG--------AKVKSSYVENVPEG----ADAE 74 (355) T ss_dssp ---CCCCCEEEEEECSSCGGG----------SSHHHHHHHHHHHHHHHHG--------GGEEEEEECSCCST----HHHH T ss_pred CCCCCCCCeEEEEEEccCCCc----------cchHHHHHHHHHHHHHHhC--------CCcEEEEEecCCCc----ccHH Confidence 344566789999999864211 1245667777777777653 33443333322221 1222 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRL-FKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~-~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +.+++++. .++|+||+...... ..+..++++ .++|+|..+...+ .+++..+. T Consensus 75 ~~l~~l~~-------------------~~~d~II~~~~~~~-~~~~~~a~~~~~i~~v~~~~~~~-------~~~~~~v~ 127 (355) T 6PII_A 75 RVIRKLAA-------------------DGNKLIFTTSFGFM-NPTERVAKAFPNVVFEHATGVKL-------AKNLGVYE 127 (355) T ss_dssp HHHHHHHH-------------------TTCSEEEECSGGGH-HHHHHHHHHCTTSEEEEESCCCC-------BTTEEEEE T ss_pred HHHHHHHH-------------------CCCCEEEEcChhhH-HHHHHHHHHCCCCEEEEcccCCC-------cCCEEEec Confidence 33333332 46788876543322 223333433 6899988765432 12344555 Q NP_000836.2 197 PPDSYQAQAMVDIVTA-LGWNYVSTLASE-GNYGESGVEAFTQISREIG-GVCIAQSQKIPREP-RPGEFEKIIKRLLET 272 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~-~~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~ 272 (908) .+....+..++.++.. .+.++|+++... ......+.++|.+.+++.+ .+.+... +.... +.....+.+++++. T Consensus 128 ~d~~~~g~~ag~~a~~~~~~~~i~~i~~~~~~~~~~~~~gf~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~ll~- 204 (355) T 6PII_A 128 SRQYEGTYLQGVLAAKMTKTGVIGFVGSFPVPEVIRNINAYTLGAQSVNPKIKTKVI--WVSTWYDPAKERQAAETLIA- 204 (355) T ss_dssp ECTHHHHHHHHHHHHHHCSSSEEEEEESCCCHHHHHHHHHHHHHHHTTCTTCEEEEE--ECSSSCCHHHHHHHHHHHHH- T ss_pred cchHHHHHHHHHHHHHHcCCCcEEEEeCCCchHHHHHHHHHHHHHHHhCCCCEEEEE--EccCCCCHHHHHHHHHHHHH- Confidence 5665566655555443 356789988743 2344566777877776532 1222111 11001 11122344555553 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g 298 (908) .++|+|+...+ +..+++++++.| T Consensus 205 ~~~d~I~~~~~---a~gv~~a~~~~g 227 (355) T 6PII_A 205 QGADVLTQNTN---SPATLQVAQEKG 227 (355) T ss_dssp TTCCEEEESSS---SSHHHHHHHHTT T ss_pred CCCCEEEeCCC---CHHHHHHHHHhC Confidence 47888877653 356677776655 No 313 >6RQG_A 46 kDa surface antigen; immunodominant surface protein Mycoplasma hyopneumoniae; 3.1A {Mycoplasma hyopneumoniae J} Probab=94.68 E-value=0.00085 Score=68.97 Aligned_cols=92 Identities=14% Similarity=-0.013 Sum_probs=52.0 Template_Neff=8.700 Q NP_000836.2 145 DKISGVIGAAASS-VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTAL---------- 213 (908) Q Consensus 145 ~~v~~vIg~~~s~-~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~---------- 213 (908) .++|++|...... ........+...++|+|.++...+.. ......+..++...++.+++++.+. T Consensus 76 ~~~dgIIi~~~~~~~~~~~~~~~~~~giPvV~~~~~~~~~-----~~~~~~V~~d~~~~g~~a~~~l~~~~~~~~~~~~~ 150 (387) T 6RQG_A 76 PAPKGFIIAPENGSGVGTAVNTIADKGIPIVAYDRLITGS-----DKYDWYVSFDNEKVGELQGLSLAAGLLGKEDGAFD 150 (387) T ss_dssp SCCSCEEECCSSTTTTHHHHHHHHTTTCCEEEESSCCCSC-----CCCCEEEEECHHHHHHHHHHHHHHHHHTCCSSCCS T ss_pred cCCCEEEEeCCCcccHHHHHHHHHHCCCCEEEEecCCCCC-----CcccEEEEcCHHHHHHHHHHHHHHHhcCCCCCCcc Confidence 4678777543322 22233445667899999887643310 1234455566666666666665322 Q NP_000836.2 214 ---------------GWNYVSTLAS--EGNYGESGVEAFTQISRE 241 (908) Q Consensus 214 ---------------~~~~v~ii~~--~~~~~~~~~~~~~~~~~~ 241 (908) +.++++++.. .+.....+.++|.+.+++ T Consensus 151 ~~~~~~~~~~~~~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~l~~ 195 (387) T 6RQG_A 151 SIDQMNEYLKSHMPQETISFYTIAGSQDDNNSQYFYNGAMKVLKE 195 (387) T ss_dssp SHHHHHHHHHHTCCSSCEEEEECBCCTTSHHHHHHHHHHHHHHHH T ss_pred chHHHhHHHHHhCCCCceEEEEEECCCCChhHHHHHHHHHHHHHH Confidence 2467777753 223445567777777765 No 314 >6RUX_C Surface antigen P46; immunodominant surface protein Mycoplasma hyopneumoniae; HET: MAL; 2.5A {Mycoplasma hyopneumoniae J} Probab=94.68 E-value=0.00085 Score=68.97 Aligned_cols=92 Identities=14% Similarity=-0.013 Sum_probs=52.0 Template_Neff=8.700 Q NP_000836.2 145 DKISGVIGAAASS-VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTAL---------- 213 (908) Q Consensus 145 ~~v~~vIg~~~s~-~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~---------- 213 (908) .++|++|...... ........+...++|+|.++...+.. ......+..++...++.+++++.+. T Consensus 76 ~~~dgIIi~~~~~~~~~~~~~~~~~~giPvV~~~~~~~~~-----~~~~~~V~~d~~~~g~~a~~~l~~~~~~~~~~~~~ 150 (387) T 6RUX_C 76 PAPKGFIIAPENGSGVGTAVNTIADKGIPIVAYDRLITGS-----DKYDWYVSFDNEKVGELQGLSLAAGLLGKEDGAFD 150 (387) T ss_dssp SCCSCEEECCSSTTTTHHHHHHHHTTTCCEEEESSCCCSC-----SCCCEEEEECHHHHHHHHHHHHHHHHTTCCSSCCS T ss_pred cCCCEEEEeCCCcccHHHHHHHHHHCCCCEEEEecCCCCC-----CcccEEEEcCHHHHHHHHHHHHHHHhcCCCCCCcc Confidence 4678777543322 22233445667899999887643310 1234455566666666666665322 Q NP_000836.2 214 ---------------GWNYVSTLAS--EGNYGESGVEAFTQISRE 241 (908) Q Consensus 214 ---------------~~~~v~ii~~--~~~~~~~~~~~~~~~~~~ 241 (908) +.++++++.. .+.....+.++|.+.+++ T Consensus 151 ~~~~~~~~~~~~~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~l~~ 195 (387) T 6RUX_C 151 SIDQMNEYLKSHMPQETISFYTIAGSQDDNNSQYFYNGAMKVLKE 195 (387) T ss_dssp SHHHHHHHHHHTCCSSCEEEEECBCCTTSHHHHHHHHHHHHHHHH T ss_pred chHHHhHHHHHhCCCCceEEEEEECCCCChhHHHHHHHHHHHHHH Confidence 2467777753 223445567777777765 No 315 >6S3T_T 46 kDa surface antigen, Immunoglobulin; immunodominant surface protein Mycoplasma hyopneumoniae; HET: XYP; 3.5A {Mycoplasma hyopneumoniae J} Probab=94.68 E-value=0.00085 Score=68.97 Aligned_cols=92 Identities=14% Similarity=-0.013 Sum_probs=52.0 Template_Neff=8.700 Q NP_000836.2 145 DKISGVIGAAASS-VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTAL---------- 213 (908) Q Consensus 145 ~~v~~vIg~~~s~-~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~---------- 213 (908) .++|++|...... ........+...++|+|.++...+.. ......+..++...++.+++++.+. T Consensus 76 ~~~dgIIi~~~~~~~~~~~~~~~~~~giPvV~~~~~~~~~-----~~~~~~V~~d~~~~g~~a~~~l~~~~~~~~~~~~~ 150 (387) T 6S3T_T 76 PAPKGFIIAPENGSGVGTAVNTIADKGIPIVAYDRLITGS-----DKYDWYVSFDNEKVGELQGLSLAAGLLGKEDGAFD 150 (387) T ss_dssp SCCSCEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCCSC-----CCCCEEEEECHHHHHHHHHHHHHHHHTTCCSSCCS T ss_pred cCCCEEEEeCCCcccHHHHHHHHHHCCCCEEEEecCCCCC-----CcccEEEEcCHHHHHHHHHHHHHHHhcCCCCCCcc Confidence 4678777543322 22233445667899999887643310 1234455566666666666665322 Q NP_000836.2 214 ---------------GWNYVSTLAS--EGNYGESGVEAFTQISRE 241 (908) Q Consensus 214 ---------------~~~~v~ii~~--~~~~~~~~~~~~~~~~~~ 241 (908) +.++++++.. .+.....+.++|.+.+++ T Consensus 151 ~~~~~~~~~~~~~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~l~~ 195 (387) T 6S3T_T 151 SIDQMNEYLKSHMPQETISFYTIAGSQDDNNSQYFYNGAMKVLKE 195 (387) T ss_dssp CHHHHHHHHHHSCCSSCEEEEECBCCTTSTHHHHHHHHHHHHHHH T ss_pred chHHHhHHHHHhCCCCceEEEEEECCCCChhHHHHHHHHHHHHHH Confidence 2467777753 223445567777777765 No 316 >4FE4_A Xylose operon regulatory protein; dauixie, d-xylose, XylR, DNA looping; 3.45A {Escherichia coli} Probab=94.62 E-value=0.00092 Score=69.19 Aligned_cols=148 Identities=14% Similarity=0.103 Sum_probs=82.2 Template_Neff=11.500 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++|++|.+..+ ......++..++|+|..+...+... ..+....+..++...++.+++++.+.+.++++++... T Consensus 55 ~~~dgiI~~~~~---~~~~~~~~~~~ipvv~~~~~~~~~~---~~~~~~~v~~d~~~~g~~~~~~l~~~g~~~i~~i~~~ 128 (392) T 4FE4_A 55 WLGDGVIADFDD---KQIEQALADVDVPIVGVGGSYHLAE---SYPPVHYIATDNYALVESAFLHLKEKGVNRFAFYGLP 128 (392) T ss_dssp CCCSEEEEETTS---HHHHTTSTTCCSCEEEECBCCSSGG---GCCSSEECEECHHHHHHHHHHHHHHHSCCCEEEECCC T ss_pred hcCCEEEEeCCC---HHHHHHHhcCCCCEEEecCCccccC---CCCCCeEEEeCHHHHHHHHHHHHHHcCCCeEEEeCCc Confidence 467777765322 2233445667999998776432100 1234456667777778888888866678889988753 Q NP_000836.2 225 GN----YGESGVEAFTQISREIGGVCIAQSQKI-PREPRPGEFEKIIKRLLE-TPNARAVIMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 225 ~~----~~~~~~~~~~~~~~~~~~i~v~~~~~~-~~~~~~~~~~~~~~~l~~-~~~~~viv~~~~~~~~~~~l~~~~~~g 298 (908) .. ....+.++|.+.+++. +......... ....+..+....++++++ ..++|+|++.. +..+..+++++.+.| T Consensus 129 ~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ii~~~-d~~a~~~~~al~~~g 206 (392) T 4FE4_A 129 ESSGKRWATEREYAFRQLVAEE-KYRGVVYQGLETAPENWQHAQNRLADWLQTLPPQTGIIAVT-DARARHILQVCEHLH 206 (392) T ss_dssp TTSSCCHHHHHHHHHHHHHTTS-SSCEEEECCCCSSCSSHHHHHHHHHHHHHHSCSSEEEEESS-TTHHHHHHHHHHHTT T ss_pred hhhcchHHHHHHHHHHHHHHhh-ccceeecCCCCCCCccHHHHHHHHHHHHHcCCCCcEEEEeC-cHHHHHHHHHHHHcC Confidence 32 3456677888877654 2221111000 000111122334444432 12467776654 445667778888777 Q NP_000836.2 299 QS 300 (908) Q Consensus 299 ~~ 300 (908) +. T Consensus 207 ~~ 208 (392) T 4FE4_A 207 IP 208 (392) T ss_dssp CC T ss_pred CC Confidence 64 No 317 >4FE7_A Xylose operon regulatory protein; HTH_ARAC, Helix-turn-helix, PBP, periplasmic binding; HET: XYS; 2.9A {Escherichia coli} Probab=94.42 E-value=0.0012 Score=68.89 Aligned_cols=205 Identities=12% Similarity=0.051 Sum_probs=108.3 Template_Neff=11.100 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ......+..+||++.|. .. .+...+..+++.++++.+ +.+.+ .+.. +. .. T Consensus 18 ~~~~~~~~~~I~v~~~~-~~------------~~~~~~~~g~~~~a~~~g--------~~~~~--~~~~-~~----~~-- 67 (412) T 4FE7_A 18 GSHMFTKRHRITLLFNA-NK------------AYDRQVVEGVGEYLQASQ--------SEWDI--FIEE-DF----RA-- 67 (412) T ss_dssp ---CCCCCEEEEEECCT-TS------------HHHHHHHHHHHHHHHHHT--------CCEEE--EECC--C----C--- T ss_pred CCCcCCCceEEEEEEeC-Cc------------HHHHHHHHHHHHHHHHcC--------CCcEE--Eeec-ch----Hh-- Confidence 34556678999999986 21 255667778777776643 22222 2221 11 11 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .++.+.. ..+|++|.+... ......+...++|+|..+...+.. ...+....+.. T Consensus 68 -~~~~~~~-------------------~~~dgiI~~~~~---~~~~~~~~~~~ipvv~~~~~~~~~---~~~~~~~~v~~ 121 (412) T 4FE7_A 68 -RIDKIKD-------------------WLGDGVIADFDD---KQIEQALADVDVPIVGVGGSYHLA---ESYPPVHYIAT 121 (412) T ss_dssp ---------------------------CCCSEEEEETTC---HHHHHHHTTCCSCEEEEEECCSSG---GGSCSSEEEEE T ss_pred -hHHHHHh-------------------hCCCEEEEeCCC---HHHHHHHhcCCCCEEEecCCcccc---CCCCCCcEEEe Confidence 1222211 456777765322 223344566799999887643210 01233455667 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEG----NYGESGVEAFTQISREIGGVCIAQSQK-IPREPRPGEFEKIIKRLLE- 271 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~----~~~~~~~~~~~~~~~~~~~i~v~~~~~-~~~~~~~~~~~~~~~~l~~- 271 (908) ++...++.+++++.+.+.++++++.... .....+.++|++.+++. +........ .....+..+....++++++ T Consensus 122 d~~~~g~~a~~~l~~~g~~~i~~i~~~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~ 200 (412) T 4FE7_A 122 DNYALVESAFLHLKEKGVNRFAFYGLPESSGKRWATEREYAFRQLVAEE-KYRGVVYQGLETAPENWQHAQNRLADWLQT 200 (412) T ss_dssp CHHHHHHHHHHHHHHTTCCEEEEECCCTTSCCHHHHHHHHHHHHHHTTS-SSCCEEECCSCSSCSSHHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHcCCCeEEEecCCcccccchHHHHHHHHHHHHhhc-CceeeeecCcccCCccHHHHHHHHHHHHHc Confidence 7777788888888666778898887432 23556677888877764 232111100 0000111122334444432 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ..++++|++.. +..+..+++++.+.|+. T Consensus 201 ~~~~~~ii~~~-d~~a~~~~~al~~~g~~ 228 (412) T 4FE7_A 201 LPPQTGIIAVT-DARARHILQVCEHLHIP 228 (412) T ss_dssp SCTTEEEEESS-HHHHHHHHHHHHHHTCC T ss_pred CCCCeEEEEeC-cHHHHHHHHHHHHCCCC Confidence 12467776653 44556777788777764 No 318 >2HQB_A Transcriptional activator of comK gene; Berkeley Structure Genomics Center Target; 2.7A {Bacillus halodurans} Probab=93.50 E-value=0.0031 Score=61.96 Aligned_cols=140 Identities=9% Similarity=-0.001 Sum_probs=72.1 Template_Neff=11.200 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRL-FKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVT-ALGWNYVSTLA 222 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~-~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~-~~~~~~v~ii~ 222 (908) .++|+||....... .....+++. .++|+|..+...+ .+.+..+..+....+..++.++. ..+.++|+++. T Consensus 62 ~~~d~Ii~~~~~~~-~~~~~~a~~~~~i~~v~~~~~~~-------~~~~~~v~~d~~~~~~~a~~~~~~~~~~~~i~~i~ 133 (296) T 2HQB_A 62 GGVNLIFGHGHAFA-EYFSTIHNQYPDVHFVSFNGEVK-------GENITSLHFEGYAMGYFGGMVAASMSETHKVGVIA 133 (296) T ss_dssp TTCCEEEECSTHHH-HHHHTTTTSCTTSEEEEESCCCC-------SSSEEEEEECCHHHHHHHHHHHHHTCSSSEEEEEE T ss_pred CCCCEEEEeCHHHH-HHHHHHHHHCCCcEEEEecCCcC-------CCCEEEEEechhHHHHHHHHHHHHhcCCCcEEEEe Confidence 47888876543322 223333332 6899988765432 13344555555556666666654 45678899887 Q NP_000836.2 223 SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPR-PGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 223 ~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~-~~~~~~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g 298 (908) .... ..+.++|.+.+++.+...+.. .+..... .......++++.. .++|+|+... +..+..+++++++.| T Consensus 134 ~~~~--~~~~~gf~~~~~~~~~~~~~~--~~~~~~~d~~~~~~~~~~~~~-~~~d~i~~~~-~~~~~~~~~a~~~~g 204 (296) T 2HQB_A 134 AFPW--QPEVEGFVDGAKYMNESEAFV--RYVGEWTDADKALELFQELQK-EQVDVFYPAG-DGYHVPVVEAIKDQG 204 (296) T ss_dssp SCTT--CHHHHHHHHHHHHTTCCEEEE--EECSSSSCHHHHHHHHHHHHT-TTCCEEECCC-TTTHHHHHHHHHHHT T ss_pred cCCC--chHHHHHHHHHHHhCCCceEE--EEeCCCCCHHHHHHHHHHHHH-CCCCEEEEcC-CcccHHHHHHHHHcC Confidence 5432 235667776665432111110 0110011 1122334444443 4678877653 444556677776655 No 319 >6SHU_A Basic membrane protein D; transporter, nucleoside, purine, TRANSPORT PROTEIN; HET: ADN; 1.43002869382A {Borrelia burgdorferi (strain JD1)} Probab=93.26 E-value=0.0039 Score=63.47 Aligned_cols=205 Identities=10% Similarity=-0.043 Sum_probs=106.0 Template_Neff=10.300 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ......+||++.|..... ..+......+++.+.++.| +++ ...+. ++ ....+.+ T Consensus 43 ~~~~~~~I~~i~~~~~~d----------~~~~~~~~~g~~~~~~~~g--------~~~--~~~~~--~~----~~~~~~l 96 (361) T 6SHU_A 43 GKSEAKTVSLIVDGAFDD----------KGFNESSSKAIRKLKADLN--------INI--IEKAS--TG----NSYLGDI 96 (361) T ss_dssp -CCTTCEEEEEEESCSCS----------SSHHHHHHHHHHHHHHHHC--------CEE--EEEEE--CG----GGHHHHH T ss_pred CCcCCcEEEEEECCCCCC----------CchHHHHHHHHHHHHHHhC--------CeE--EEcCC--Cc----cchHHHH Confidence 445678999999853211 1245567777777776653 222 22221 11 1222333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRL-FKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~-~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++.. .++|+||+..... ...+..+++. .++|++.++...+... ..+++..+..+. T Consensus 97 ~~l~~-------------------~~~d~II~~~~~~-~~~~~~~a~~~~~i~~v~~~~~~~~~~---~~~~~~~v~~d~ 153 (361) T 6SHU_A 97 ANLED-------------------GNSNLIWGIGFRL-SDILFQRASENVSVNYAIIEGVYDEIQ---IPKNLLNISFRS 153 (361) T ss_dssp HHHHH-------------------TTCSEEEEESGGG-HHHHHHHHHHCTTSCEEEESCCCSSCC---CCTTEEEEEECH T ss_pred HHHHh-------------------CCCCEEEEeChhh-HHHHHHHHHhCCCCcEEEeecCCcccc---CcCCEEEEEeCH Confidence 43332 4788888653322 2223333332 6899888776432100 123455566666 Q NP_000836.2 200 SYQAQAMVDIVTA-LGWNYVSTLASE-GNYGESGVEAFTQISREIG-GVCIAQSQKIPREP-RPGEFEKIIKRLLETPNA 275 (908) Q Consensus 200 ~~~~~~~~~~l~~-~~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~~~~ 275 (908) ...+..++.++.. .+.++|+++... ......+.++|.+.+++.+ .+.+... +..+. +.....+.++++.. .++ T Consensus 154 ~~~~~lag~~~~~~~~~~~ig~i~~~~~~~~~~~~~gf~~~~~~~~~~~~~~~~--~~~~~~d~~~a~~~~~~~~~-~~~ 230 (361) T 6SHU_A 154 EEVAFLAGYFASKASKTGKIGFVGGVRGKVLESFMYGYEAGAKYANSNIKVVSQ--YVGTFGDFGLGRSTASNMYR-DGV 230 (361) T ss_dssp HHHHHHHHHHHHHHCSSSEEEEEESSCSHHHHHHHHHHHHHHHHHCTTCEEEEE--ECSSSSCHHHHHHHHHHHHH-TTC T ss_pred HHHHHHHHHHHHHHcCCCeEEEEeCCCChHHHHHHHHHHHHHHHHCcCCEEEEE--ECCCCCChHHHHHHHHHHHH-cCC Confidence 6666666666544 456789998743 2344556677777765532 1222111 11001 11123344555553 478 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g 298 (908) |+|+... +..+..+++++++.| T Consensus 231 d~I~~~~-~~~~~g~~~a~~~~g 252 (361) T 6SHU_A 231 DIIFAAA-GLSGIGVIEAAKELG 252 (361) T ss_dssp CEEEEES-THHHHHHHHHHHHHC T ss_pred CEEEECC-chHHHHHHHHHHHHC Confidence 8887764 345566777777765 No 320 >4P98_A Basic membrane lipoprotein; Structural Genomics, PSI-Biology, Midwest Center; HET: MLY, MLZ, BR; 1.9A {Conexibacter woesei} Probab=91.79 E-value=0.01 Score=58.80 Aligned_cols=133 Identities=5% Similarity=-0.089 Sum_probs=64.4 Template_Neff=11.000 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILR-LFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTA-LGWNYVSTLA 222 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~-~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v~ii~ 222 (908) +++|+||+...... .....+.+ ..++|++..+...+... ..+++..+..+....+..+..++.. .+.++|+++. T Consensus 74 ~~~d~Ii~~~~~~~-~~~~~~~~~~~~i~~v~~~~~~~~~~---~~~~~~~v~~~~~~~~~~ag~~~~~~~~~~~i~~i~ 149 (317) T 4P98_A 74 RGFDLVVGHGIDVS-EPILRVATEFPDVHFSASGDATLAER---LPPNVDGWTYDFGQLGYLDGFVAGSLRGVEKVGAVG 149 (317) T ss_dssp TTCSEEEEESHHHH-HHHHHHHTTCTTSEEEEECCGGGGGG---CCTTEEEEEECHHHHHHHHHHHHHTSSSCCEEEEEE T ss_pred CCCCEEEEeCHHhH-HHHHHHHHHCCCCEEEEccCcchhcc---CCCCeEEEEeehHHHHHHHHHHHHHHcCCCcEEEEe Confidence 57888886543321 22222222 35899887665332100 0234444555555455555544432 3567899987 Q NP_000836.2 223 SE-GNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFAN 283 (908) Q Consensus 223 ~~-~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~~ 283 (908) .. ......+.++|.+.+++.+ .+.+........ .+.....+.++++++ .++|+|+...+ T Consensus 150 ~~~~~~~~~~~~gf~~~~~~~~~~~~~~~~~~~~~-~d~~~~~~~~~~l~~-~~~d~i~~~~~ 210 (317) T 4P98_A 150 GPQLPFVLATHKGIRAGLKAANPRASYEETYTGRF-YDLQKEQEAARGLLD-KGAQLLVATDD 210 (317) T ss_dssp SSCCHHHHHHHHHHHHHHHHHCTTCEEEEEECSSS-SCHHHHHHHHHHHHH-TTCSSEEESSC T ss_pred CCCChHHHHHHHHHHHHHHHHCCCCEEEEEEccCC-CCHHHHHHHHHHHHH-CCCCEEEECCC Confidence 43 2234456677777776531 122221110000 011223345555553 47888777643 No 321 >4PEV_C solute binding protein; Structural Genomics, PSI-Biology, Midwest Center; HET: ADN, MSE; 2.58A {Aeropyrum pernix} Probab=90.15 E-value=0.022 Score=58.94 Aligned_cols=145 Identities=11% Similarity=-0.042 Sum_probs=70.8 Template_Neff=9.100 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANIL-RLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAM----VDIVTA-----LG 214 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~-~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~----~~~l~~-----~~ 214 (908) .++|+||....... .....++ ...++|++..+...+. ..+++..+..+....+..+ +.++.+ .+ T Consensus 110 ~g~D~II~~~~~~~-~~~~~~a~~~~~i~fv~~~~~~~~-----~~~nv~~v~~d~~~~g~laG~~aa~~~~~~~~~~~g 183 (422) T 4PEV_C 110 GEYDLIVLVGFLWQ-EPLEKVAPRYPEQKYALIDAATRE-----RYDNVASYLFREQEVASLVGIIAADIANNISKATGE 183 (422) T ss_dssp CCCSEEEEESGGGH-HHHHHHHHHCTTSEEEEESBCCSS-----CCTTEEEEEECHHHHHHHHHHHHHHHHHHHHHHHSS T ss_pred CCCCEEEEeCcccH-HHHHHHHHHCCCCeEEEEeCCCcc-----CCCCEEEEEECHHHHHHHHHHHHHHHHhhHhhhhCC Confidence 47888886543322 1122222 2468998877654321 0123334444444433333 333321 24 Q NP_000836.2 215 WNYVSTLASE-GNYGESGVEAFTQISREIG-----GVCIAQSQKIPREP-RPGEFEKIIKRLLETPNARAVIMFANEDDI 287 (908) Q Consensus 215 ~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~-----~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~~~~~viv~~~~~~~~ 287 (908) .++|++|... ......+.++|.+.+++.+ .+.+... +.... +.......++++.. .++|+|+... +... T Consensus 184 ~~~Ig~i~g~~~~~~~~~~~gf~~g~~~~~~~~~~~~~v~~~--~~~~~~d~~~a~~~a~~ll~-~g~dvI~~~~-~~~a 259 (422) T 4PEV_C 184 EAKAGAVAGMDIPPLWRFHIGYLYGVQYYNQAMGTDVEMVWT--YTGRFDDPTLGKTTAEQMLQ-QGVRVFYGVA-GLTH 259 (422) T ss_dssp CCEEEEEECCCSHHHHHHHHHHHHHHHHHHHTTTCCCCEEEE--ECSCSSCHHHHHHHHHHHHH-TTEEEEEEES-TTHH T ss_pred CCEEEEEECCCChHHHHHHHHHHHHHHHHCHhcCCCCEEEEE--EecCCCChHHHHHHHHHHHH-CCCCEEEEcc-chhh Confidence 6789888743 2334456667777665531 1122111 11001 11122344555553 4788877664 4445 Q NP_000836.2 288 RRILEAAKKLNQ 299 (908) Q Consensus 288 ~~~l~~~~~~g~ 299 (908) ..+++++++.++ T Consensus 260 ~gv~~a~~~~g~ 271 (422) T 4PEV_C 260 VGMFNAVKEAAA 271 (422) T ss_dssp HHHHHHHHHHHH T ss_pred HHHHHHHHHHHH Confidence 667777777765 No 322 >5ER3_A Sugar ABC transporter, periplasmic sugar-binding; Structural Genomics, PSI-Biology, Midwest Center; HET: GOL, MSE; 2.105A {Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)} Probab=89.00 E-value=0.032 Score=55.66 Aligned_cols=91 Identities=11% Similarity=-0.005 Sum_probs=54.2 Template_Neff=10.900 Q NP_000836.2 145 DKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALG--WNYVSTL 221 (908) Q Consensus 145 ~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~--~~~v~ii 221 (908) .++|++|....... .......+. .++|+|..+...+. ......+..++...++.+++++.+.+ .++++++ T Consensus 237 ~~~dgii~~~~~~~~~~~~~~~~~-~~ipvv~~~~~~~~------~~~~~~v~~d~~~~g~~aa~~l~~~~~~~~~i~~i 309 (341) T 5ER3_A 237 AKVDGIAISPIDPENQVAMINDAC-KVTPVICQDSDAPA------SRRKFYLGTSNYLAGRAAGKLIQEAIPEGGEVMLF 309 (341) T ss_dssp TTCSEEEECCSSGGGCHHHHHHHH-TTSCEEEESSCCTT------SCCSCEEECCHHHHHHHHHHHHHHHCTTCEEEEEE T ss_pred CCCCEEEECCCCHHHHHHHHHHHh-hCCCEEEEcCCCCc------ccCcEEEeCCHHHHHHHHHHHHHHHCCCCcEEEEE Confidence 46787775433322 122233445 68999987754321 12345566777777888888875543 3788888 Q NP_000836.2 222 ASEG--NYGESGVEAFTQISREI 242 (908) Q Consensus 222 ~~~~--~~~~~~~~~~~~~~~~~ 242 (908) .... .....+.++|++.+++. T Consensus 310 ~~~~~~~~~~~r~~g~~~~l~~~ 332 (341) T 5ER3_A 310 VGKMEVLNAQERSQGIMDELAGK 332 (341) T ss_dssp ESCTTSHHHHHHHHHHHHHHTTC T ss_pred ECCCCChhHHHHHHHHHHHHhcC Confidence 7432 23445667777777664 No 323 >3QI7_A Putative transcriptional regulator; PERIPLASMIC BINDING PROTEIN-LIKE, STRUCTURAL GENOMICS; 1.86A {Clostridium difficile} Probab=87.09 E-value=0.055 Score=54.67 Aligned_cols=152 Identities=12% Similarity=0.065 Sum_probs=79.5 Template_Neff=9.900 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++++++..............+...++|+|......+....-........+..++...++.+++++.+.+.++++++... T Consensus 86 ~~~d~ii~~~~~~~~~~~i~~~~~~gi~~iii~~~~~~~~~v~~~~~~~~V~~D~~~~g~~a~~~l~~~g~~~i~~i~~~ 165 (371) T 3QI7_A 86 KEVQAIVVSTDQAGLLPALQKVKEKRPEIITISAPMGDDKNQLSQFVDVNLGVSAEERGKVLAERSKEMGAKAFIHYAST 165 (371) T ss_dssp TTEEEEEEECSSCCCHHHHHHHHHHCTTSEEEESSCCSCHHHHHHHSSEEEECCHHHHHHHHHHHHHHTTCSCEEEEEET T ss_pred CCCcEEEEeCCCCchHHHHHHHHHhCCCEEEEeCCCCCChhHHcccccEEEECChHHHHHHHHHHHHHCCCCEEEEEeCC Confidence 46777775433322223334456678998877654321000000002344566666777778888766677788888743 Q NP_000836.2 225 GN----YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL---------ETPNARAVIMFANEDDIRRIL 291 (908) Q Consensus 225 ~~----~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~---------~~~~~~viv~~~~~~~~~~~l 291 (908) .. ....+.++|++.+++. ++.+....... .........+++++ ...++++|+.. ++..+..++ T Consensus 166 ~~~~~~~~~~R~~gf~~~l~~~-gi~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~~~~~~~~~ai~~~-~d~~a~g~~ 241 (371) T 3QI7_A 166 DDLKDVNIAKRLEMIKETCKNI-GLPFVQVNTPN--INTEEDKNKVKQFLNEDIEKQVKKYGKDINVFGV-NEYMDEVIL 241 (371) T ss_dssp TGGGSHHHHHHHHHHHHHHHHT-TCCEEEEEECC--CSSTHHHHHHHHHHHHHHHHHHHHHCSCCEEEES-SHHHHHHHH T ss_pred ccccchhHHHHHHHHHHHHHHc-CCCeeeeecCC--CCCHHHHHHHHHHHHHHHHHHHHHHCCcEEEEEc-ChhhHHHHH Confidence 22 2456778888888875 35433211101 11111111222221 11346666654 344567788 Q NP_000836.2 292 EAAKKLNQS 300 (908) Q Consensus 292 ~~~~~~g~~ 300 (908) +++++.|.. T Consensus 242 ~al~~~g~~ 250 (371) T 3QI7_A 242 TKALELKYI 250 (371) T ss_dssp HHHHHHCCB T ss_pred HHHHHCCCE Confidence 888877763 No 324 >6U1N_R Muscarinic acetylcholine receptor M2,Vasopressin V2; Arrestin, GPCR, complex, signaling, SIGNALING; HET: SEP, 2CU, TPO;{Homo sapiens} Probab=78.82 E-value=0.23 Score=52.20 Aligned_cols=34 Identities=15% Similarity=0.117 Sum_probs=18.4 Template_Neff=11.800 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+.+...+-.+++= .-|.+.+. T Consensus 99 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~Ry~~i~ 133 (509) T 6U1N_R 99 GPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVT 133 (509) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHTTTHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhh Confidence 36788888777665554443333333 33444443 No 325 >2Z73_A Rhodopsin; Visual pigment, Gq-type, G-Protein Coupled; HET: PLM, TWT, PC1, BOG, RET; 2.5A {Todarodes pacificus} Probab=72.81 E-value=0.44 Score=48.80 Aligned_cols=33 Identities=15% Similarity=0.097 Sum_probs=16.8 Template_Neff=11.900 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ...|.+..++..+++....-.+++ =..|...+. T Consensus 105 ~~~c~~~~~~~~~~~~~s~~~~~~isi~R~~ai~ 138 (448) T 2Z73_A 105 FAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIG 138 (448) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 567887776665544433333332 234544443 No 326 >3AYN_A Rhodopsin; transmembrane protein, Photoreceptor, Chromophore, Glycoprotein; HET: PC1, PLM, BOG, RET; 2.7A {Todarodes pacificus} Probab=72.81 E-value=0.44 Score=48.80 Aligned_cols=33 Identities=15% Similarity=0.097 Sum_probs=16.8 Template_Neff=11.900 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ...|.+..++..+++....-.+++ =..|...+. T Consensus 105 ~~~c~~~~~~~~~~~~~s~~~~~~isi~R~~ai~ 138 (448) T 3AYN_A 105 FAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIG 138 (448) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 567887776665544433333332 234544443 No 327 >6P9X_R Guanine nucleotide-binding protein G(s) subunit; GPCR, MEMBRANE PROTEIN;{Homo sapiens} Probab=69.60 E-value=0.58 Score=47.67 Aligned_cols=27 Identities=4% Similarity=0.007 Sum_probs=16.5 Template_Neff=10.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKT 670 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~ 670 (908) ....|.+..++..++....+..+++-. T Consensus 177 ~~~~C~~~~~~~~~~~~~s~~~l~~ia 203 (427) T 6P9X_R 177 NVGWCRLVTAAYNYFHVTNFFWMFGEG 203 (427) T ss_dssp TCHHHHHHHHHHHHHHHHHHHHHTTTH T ss_pred CchHHHHHHHHHHHHHHHHHHHHHHHH Confidence 457788877776655555555444443 No 328 >5X33_A LTB4 receptor,Lysozyme,LTB4 receptor (E.C.3.2.1.17); helix, MEMBRANE PROTEIN; HET: 7Y9; 3.7A {Cavia porcellus} Probab=69.09 E-value=0.61 Score=48.96 Aligned_cols=18 Identities=17% Similarity=0.259 Sum_probs=11.4 Template_Neff=11.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..+.+.. T Consensus 87 ~~~~C~~~~~~~~~~~~~ 104 (523) T 5X33_A 87 GLAGCRLCHYICGVSMYA 104 (523) T ss_pred chHHHHHHHHHHHHHHHH Confidence 367788877766554443 No 329 >5XSZ_A Lysophosphatidic acid receptor 6a,Endolysin,receptor (E.C.3.2.1.17); alpha helical, membrane protein; HET: OLC; 3.2A {Danio rerio} Probab=67.40 E-value=0.7 Score=47.60 Aligned_cols=34 Identities=15% Similarity=0.193 Sum_probs=17.1 Template_Neff=12.000 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAA-LLTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~-l~~K~~ri~~if 677 (908) ....|.+..++..+......-. ++.=..|.+.+. T Consensus 96 ~~~~C~~~~~~~~~~~~~s~~~~~~iaidRy~ai~ 130 (477) T 5XSZ_A 96 GSLLCKLSVSLFYTNMYGSILFLTCISVDRFLAIV 130 (477) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CChHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3678888777665444332222 222334544444 No 330 >4PXZ_A P2Y purinoceptor 12, Soluble cytochrome; purinergic receptor P2Y12, agonist-bound, G-protein; HET: CLR, 6AD, OLC; 2.5A {Homo sapiens, Escherichia coli, Homo sapiens} Probab=67.15 E-value=0.71 Score=47.32 Aligned_cols=34 Identities=21% Similarity=0.307 Sum_probs=17.4 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+++....-.+++ =..|.+.+. T Consensus 102 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 136 (466) T 4PXZ_A 102 RTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTT 136 (466) T ss_dssp HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888777665544433333333 233444443 No 331 >6IGK_A Endothelin receptor type B,Endolysin,Endothelin receptor; alpha helical, SIGNALING PROTEIN-PROTEIN BINDING; HET: CIT, OLC; 2.0A {Homo sapiens} Probab=65.67 E-value=0.8 Score=47.49 Aligned_cols=34 Identities=9% Similarity=0.173 Sum_probs=17.5 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..+.+....-.++ .=..|.+.+. T Consensus 108 ~~~~C~~~~~~~~~~~~~s~~~~~~iaidR~~ai~ 142 (498) T 6IGK_A 108 GAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVA 142 (498) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred chhHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 356788877766554443333332 2334544443 No 332 >3ODU_A C-X-C chemokine receptor type 4; Structural Genomics, PSI-2, Protein Structure; HET: OLC, OLA, ITD; 2.5A {Homo Sapiens, Enterobacteria phage T4} Probab=65.54 E-value=0.8 Score=47.55 Aligned_cols=34 Identities=18% Similarity=0.256 Sum_probs=18.7 Template_Neff=11.800 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAAL-LTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l-~~K~~ri~~if 677 (908) ....|.+..++..+++....-.+ +.=.-|.+.+. T Consensus 115 ~~~~C~~~~~~~~~~~~~s~~~~~~iaidRy~~i~ 149 (502) T 3ODU_A 115 GNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIV 149 (502) T ss_pred chhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 46789888877665544333333 33334554444 No 333 >5T04_A Neurotensin receptor type 1,Endolysin,NEUROTENSIN RECEPTOR; MEMBRANE PROTEIN, G PROTEIN-COUPLED RECEPTOR; HET: PEG, TCE; 3.3A {Rattus norvegicus} Probab=65.04 E-value=0.84 Score=47.61 Aligned_cols=16 Identities=6% Similarity=-0.145 Sum_probs=10.0 Template_Neff=11.700 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..+.+. T Consensus 107 ~~~C~~~~~~~~~~~~ 122 (513) T 5T04_A 107 DAGCRGYYFLRDACTY 122 (513) T ss_pred hHHHHHHHHHHHHHHH Confidence 5678877666554443 No 334 >3ODU_B C-X-C chemokine receptor type 4; Structural Genomics, PSI-2, Protein Structure; HET: ITD, OLC, OLA; 2.5A {Homo Sapiens} Probab=65.04 E-value=0.84 Score=47.38 Aligned_cols=35 Identities=14% Similarity=0.200 Sum_probs=18.7 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYA-ALLTKTNRIHRIFE 678 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~-~l~~K~~ri~~if~ 678 (908) ....|.+..++..+++....- .++.=.-|.+.+.+ T Consensus 115 ~~~~C~~~~~~~~~~~~~s~~~~~~iaidR~~ai~~ 150 (502) T 3ODU_B 115 GNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIVH 150 (502) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred cchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC Confidence 467888888776655443333 23333445554443 No 335 >3OE0_A C-X-C chemokine receptor type 4; Structural Genomics, PSI-2, Protein Structure; 2.9A {Homo Sapiens, Enterobacteria phage T4} Probab=61.92 E-value=1 Score=46.52 Aligned_cols=34 Identities=15% Similarity=0.206 Sum_probs=18.1 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAA-LLTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~-l~~K~~ri~~if 677 (908) ....|.+..++..+++....-. ++.=.-|.+.+. T Consensus 115 ~~~~C~~~~~~~~~~~~~s~~~l~~iaidRy~~i~ 149 (499) T 3OE0_A 115 GNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIV 149 (499) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred cchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3678888777766554433332 233334544444 No 336 >5T1A_A C-C chemokine receptor type 2; C-C Chemokine Receptor type 2; HET: SO4, 73R, VT5, YCM, OLC; 2.806A {Homo sapiens} Probab=60.86 E-value=1.1 Score=46.45 Aligned_cols=34 Identities=15% Similarity=0.207 Sum_probs=17.2 Template_Neff=11.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAAL-LTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l-~~K~~ri~~if 677 (908) ....|.+..++..+++....-.+ +.=..|.+.+. T Consensus 119 ~~~~C~~~~~~~~~~~~~s~~~l~~iaidRy~~i~ 153 (508) T 5T1A_A 119 GNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIV 153 (508) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred CchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 36778887776654443333222 22334544444 No 337 >6K41_R Guanine nucleotide-binding protein G(o) subunit; GPCR, Complex, cryo-EM, MEMBRANE PROTEIN; HET: CZX; 2.9A {Homo sapiens} Probab=60.42 E-value=1.2 Score=46.60 Aligned_cols=34 Identities=15% Similarity=0.001 Sum_probs=15.1 Template_Neff=10.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+.+....-.+++= .-|...+. T Consensus 280 ~~~~C~~~~~l~~~~~~~s~~~l~~iai~R~~ai~ 314 (512) T 6K41_R 280 RRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVS 314 (512) T ss_dssp ----CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678887777665544433333332 33444443 No 338 >6K42_R Guanine nucleotide-binding protein G(i) subunit; GPCR, Complex, cryo-EM, MEMBRANE PROTEIN; HET: CZX; 4.1A {Bos taurus} Probab=60.42 E-value=1.2 Score=46.60 Aligned_cols=34 Identities=15% Similarity=0.001 Sum_probs=17.5 Template_Neff=10.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+.+....-.+++= .-|...+. T Consensus 280 ~~~~C~~~~~l~~~~~~~s~~~l~~iai~R~~ai~ 314 (512) T 6K42_R 280 RRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVS 314 (512) T ss_dssp CSTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678887777665544433333332 33444443 No 339 >5YC8_A Muscarinic acetylcholine receptor M2,Redesigned apo-cytochrome; GPCR crystallography, rationally thermostabilized mutant; HET: 3C0; 2.5A {Homo sapiens} Probab=60.13 E-value=1.2 Score=44.60 Aligned_cols=18 Identities=6% Similarity=0.071 Sum_probs=11.5 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..++... T Consensus 94 ~~~~C~~~~~~~~~~~~~ 111 (421) T 5YC8_A 94 GPVVCDLWLALDYVVSNA 111 (421) T ss_dssp CHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHH Confidence 367788877766554443 No 340 >6N4B_R Guanine nucleotide-binding protein G(i) subunit; Cannabinoid receptor, GPCR, synthetic cannabinoid; HET: KCA, CLR; 3.0A {Homo sapiens} Probab=59.77 E-value=1.2 Score=46.18 Aligned_cols=18 Identities=6% Similarity=0.296 Sum_probs=7.9 Template_Neff=10.800 Q NP_000836.2 587 PVFVAILGIIATTFVIVT 604 (908) Q Consensus 587 ~~~~~~~~i~~~~~~~~~ 604 (908) ..++.++|++.-++++.. T Consensus 138 ~~ii~iigi~~N~lvl~~ 155 (495) T 6N4B_R 138 SLTLGTFTVLENLLVLCV 155 (495) T ss_pred HHHHHHHHHHHHHHHHHH Confidence 344444555444443333 No 341 >3VW7_A Chimera of Proteinase-activated receptor 1; High resolution structure, protease-activated receptor; HET: OLC, VPX; 2.2A {Homo sapiens, Enterobacteria phage T4, Homo sapiens} Probab=59.50 E-value=1.2 Score=45.59 Aligned_cols=34 Identities=15% Similarity=0.224 Sum_probs=17.4 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+.+....-.+++ =.-|.+.+. T Consensus 89 ~~~~C~~~~~~~~~~~~~s~~~~~~iaidRy~ai~ 123 (484) T 3VW7_A 89 GSELCRFVTAAFYCNMYASILLMTVISIDRFLAVV 123 (484) T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 3567888777765544433333332 233444443 No 342 >6GPS_A C-C chemokine receptor type 2,Rubredoxin,C-C; GPCR, Signalling, Drug-design, SIGNALING PROTEIN; HET: F7N; 3.3A {Homo sapiens} Probab=59.46 E-value=1.2 Score=44.63 Aligned_cols=23 Identities=9% Similarity=0.160 Sum_probs=13.4 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAAL 666 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l 666 (908) ....|.+..++..+++....-.+ T Consensus 108 ~~~~C~~~~~~~~~~~~~s~~~~ 130 (429) T 6GPS_A 108 GNAMCKLFTGLYHIGYFGGIFFI 130 (429) T ss_pred hHHHHHHHHHHHHHHHHHHHHHH Confidence 35678887776665544433333 No 343 >6ME8_A Soluble cytochrome b562,Melatonin receptor type; GPCR, melatonin receptor type 1B; HET: JEY; 3.1A {Escherichia coli} Probab=58.95 E-value=1.3 Score=45.24 Aligned_cols=26 Identities=15% Similarity=0.132 Sum_probs=15.9 Template_Neff=11.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK 669 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K 669 (908) ....|.+..++..+++...+-.+++- T Consensus 185 ~~~~C~~~~~~~~~~~~~s~~~~~~i 210 (460) T 6ME8_A 185 GEEHCKASAFVMGLSVIGSVWNITAI 210 (460) T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHH Confidence 36778888777766555444444443 No 344 >6ME6_A Soluble cytochrome b562,Melatonin receptor type; GPCR, melatonin receptor type 1B; HET: OLC, JEY; 2.8A {Escherichia coli} Probab=58.34 E-value=1.3 Score=45.13 Aligned_cols=34 Identities=18% Similarity=0.168 Sum_probs=17.1 Template_Neff=11.600 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+++....-.+++ -.-|...+. T Consensus 185 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 219 (460) T 6ME6_A 185 GEEHCKASAFVMGLSVIGSVWNITAIAIDRYLYIC 219 (460) T ss_dssp CSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3667888777665544433333322 233444443 No 345 >4GRV_A Neurotensin receptor type 1, Neurotensin; G-protein coupled receptor, neurotensin receptor; HET: EPE; 2.802A {Rattus norvegicus, Enterobacteria phage T4} Probab=58.13 E-value=1.4 Score=45.79 Aligned_cols=33 Identities=9% Similarity=-0.115 Sum_probs=16.5 Template_Neff=11.800 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAA-LLTKTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~-l~~K~~ri~~if 677 (908) ...|.+..++..+++....-. ++.=..|.+.+. T Consensus 107 ~~~C~~~~~~~~~~~~~s~~~~~~iai~Ry~ai~ 140 (510) T 4GRV_A 107 DAGCRGYYFLRDACTYATALNVASLSVARYLAIC 140 (510) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 567887776655444333222 233344554444 No 346 >6WWZ_R Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit; GPCR, Chemokine, Chemokine receptor, Complex; 3.34A {Rattus norvegicus} Probab=57.89 E-value=1.4 Score=46.26 Aligned_cols=33 Identities=12% Similarity=0.192 Sum_probs=17.1 Template_Neff=10.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRI 676 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~i 676 (908) ....|.+..++..+++...+-.++.- ..|...+ T Consensus 259 ~~~~C~~~~~~~~~~~~~s~~~l~~iaidRy~ai 292 (529) T 6WWZ_R 259 SNATCKLLKGIYAINFNCGMLLLTCISMDRYIAI 292 (529) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678887777665554433333332 2344444 No 347 >5ZKC_A Muscarinic acetylcholine receptor M2,Apo-cytochrome b562; GPCR crystallography, rationally thermostabilized mutant; HET: 3C0; 2.3A {Homo sapiens} Probab=57.52 E-value=1.4 Score=43.99 Aligned_cols=34 Identities=12% Similarity=0.115 Sum_probs=17.5 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..++.....-.+++ =.-|...+. T Consensus 94 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 128 (421) T 5ZKC_A 94 GPVVCDLWLALDYVVSNARVMNLLIISFDRYFCVT 128 (421) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhh Confidence 3678888877665554433333322 233444443 No 348 >5IU7_A Adenosine receptor A2a,Soluble cytochrome b562,Adenosine; G-protein-coupled receptor, integral membrane protein; HET: CLR, OLC, OLA, 6DY, OLB; 1.9A {Homo sapiens} Probab=57.19 E-value=1.4 Score=44.21 Aligned_cols=17 Identities=18% Similarity=0.092 Sum_probs=10.0 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..++.. T Consensus 82 ~~~~C~~~~~~~~~~~~ 98 (433) T 5IU7_A 82 ACHGCLFIACFVLVLAQ 98 (433) T ss_pred cchHHHHHHHHHHHHHH Confidence 35567777766554443 No 349 >5NM4_A Lysozyme C (E.C.3.2.1.17); room-temperature, serial crystallography, Signaling protein; HET: ZMA, OLA, CLR; 1.7A {Homo sapiens} Probab=57.15 E-value=1.4 Score=44.20 Aligned_cols=17 Identities=18% Similarity=0.092 Sum_probs=10.0 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..++.. T Consensus 82 ~~~~C~~~~~~~~~~~~ 98 (433) T 5NM4_A 82 ACHGCLFIACFVLVLAQ 98 (433) T ss_dssp EHHHHHHHHHHHHHHHH T ss_pred ccchHHHHHHHHHHHHH Confidence 35567777666554443 No 350 >5WIU_A D(4) dopamine receptor,Soluble cytochrome b562; GPCR, dopamine receptor, antagonist, sodium; HET: PEG, PO4, OLA, AQD; 1.962A {Homo sapiens} Probab=56.40 E-value=1.5 Score=43.87 Aligned_cols=22 Identities=9% Similarity=-0.076 Sum_probs=13.0 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAA 665 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~ 665 (908) ....|.+..++..+.+....-. T Consensus 108 ~~~~C~~~~~~~~~~~~~s~~~ 129 (422) T 5WIU_A 108 SPRLCDALMAMDVMLCTASIFN 129 (422) T ss_dssp CHHHHHHHHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHHHHHHH Confidence 3567888777765544433333 No 351 >5WIV_A D(4) dopamine receptor,Soluble cytochrome b562; GPCR, dopamine receptor, antagonist, sodium; HET: PEG, PO4, OLA, AQD; 2.143A {Homo sapiens} Probab=56.40 E-value=1.5 Score=43.87 Aligned_cols=22 Identities=9% Similarity=-0.076 Sum_probs=13.0 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAA 665 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~ 665 (908) ....|.+..++..+.+....-. T Consensus 108 ~~~~C~~~~~~~~~~~~~s~~~ 129 (422) T 5WIV_A 108 SPRLCDALMAMDVMLCTASIFN 129 (422) T ss_dssp CHHHHHHHHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHHHHHHH Confidence 3567888777765544433333 No 352 >5NDD_A Lysozyme,Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated; MEMBRANE PROTEIN, GPCR, 7TM; HET: 8TZ; 2.801A {Enterobacteria phage T4} Probab=56.28 E-value=1.5 Score=46.94 Aligned_cols=34 Identities=21% Similarity=0.221 Sum_probs=17.2 Template_Neff=11.000 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+.+....-.+++ =.-|...+. T Consensus 273 ~~~~C~~~~~l~~~~~~~s~~~l~~iaidRy~aI~ 307 (619) T 5NDD_A 273 GEALCNVLIGFFYANMYCSILFLTCLSVQRAWEIV 307 (619) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888777665544433333333 233444443 No 353 >4IB4_A Human 5-HT2B receptor_BRIL chimera; ergotamine, Novel protein engineering, GPCR; HET: CLR, PLM, OLA, ERM, PEG, OLC, OLB; 2.7A {Homo sapiens} Probab=56.21 E-value=1.5 Score=43.85 Aligned_cols=34 Identities=18% Similarity=0.037 Sum_probs=17.5 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+++....-.+++ -.-|...+. T Consensus 99 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 133 (430) T 4IB4_A 99 PLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIK 133 (430) T ss_dssp CTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred cccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 3567888777765554433333333 233444443 No 354 >6AK3_A Prostaglandin E2 receptor EP3 subtype,Soluble; GPCR, lipid, signaling protein, prostanoid; HET: POV, P2E; 2.9A {Homo sapiens} Probab=55.29 E-value=1.6 Score=43.47 Aligned_cols=19 Identities=16% Similarity=0.140 Sum_probs=11.2 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFS 662 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~ 662 (908) ....|.+..++..+.+... T Consensus 88 ~~~~c~~~~~~~~~~~~~s 106 (418) T 6AK3_A 88 SGRLCTFFGLTMTVFGLSS 106 (418) T ss_dssp GGHHHHHHHHHHHHHHHHH T ss_pred CchhHHHHHHHHHHHHHHH Confidence 3467887776665444433 No 355 >6AK3_B Prostaglandin E2 receptor EP3 subtype,Soluble; GPCR, lipid, signaling protein, prostanoid; HET: P2E, POV; 2.9A {Homo sapiens} Probab=55.29 E-value=1.6 Score=43.47 Aligned_cols=19 Identities=16% Similarity=0.140 Sum_probs=10.8 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFS 662 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~ 662 (908) ....|.+..++..+.+... T Consensus 88 ~~~~c~~~~~~~~~~~~~s 106 (418) T 6AK3_B 88 SGRLCTFFGLTMTVFGLSS 106 (418) T ss_dssp -CHHHHHHHHHHHHHHHHH T ss_pred CchhHHHHHHHHHHHHHHH Confidence 3467887776665444433 No 356 >6M9T_A Prostaglandin E2 receptor EP3 subtype,Endolysin; GPCR, prostaglandin E2 receptor 3; HET: SO4, OLA, J9P, OLC; 2.5A {Homo sapiens} Probab=54.94 E-value=1.7 Score=45.58 Aligned_cols=17 Identities=12% Similarity=0.104 Sum_probs=10.2 Template_Neff=11.200 Q NP_000836.2 645 TIICSFRRVFLGLGMCF 661 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l 661 (908) ...|.+..++..+++.. T Consensus 139 ~~~C~~~~~~~~~~~~~ 155 (537) T 6M9T_A 139 GRLCTFFGLTMTVFGLS 155 (537) T ss_pred hhHHHHHHHHHHHHHHH Confidence 46777777665544443 No 357 >5ZKP_A Platelet-activating factor receptor,Flavodoxin; G protein-coupled receptor, Platelet-activating factor; HET: 9ER, FMN; 2.81A {Homo sapiens} Probab=54.81 E-value=1.7 Score=44.22 Aligned_cols=34 Identities=18% Similarity=0.216 Sum_probs=16.9 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..+......-.++ .=.-|.+.+. T Consensus 88 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~Ry~~i~ 122 (466) T 5ZKP_A 88 PKFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVT 122 (466) T ss_pred hhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 356788877765544433333322 2334444444 No 358 >5ZKQ_A Platelet-activating factor receptor; G protein-coupled receptor, Platelet-activating factor; HET: SO4, 9EU, OLC; 2.9A {Homo sapiens} Probab=54.65 E-value=1.7 Score=43.68 Aligned_cols=18 Identities=6% Similarity=0.264 Sum_probs=11.5 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..++... T Consensus 88 ~~~~C~~~~~~~~~~~~~ 105 (438) T 5ZKQ_A 88 PKFLCNVAGCLFFINTYC 105 (438) T ss_dssp CHHHHHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHHH Confidence 367788887766554443 No 359 >5W0P_C T4 lysozyme-human rhodopsin-mouse visual arrestin; rhodopsin, GPCR, arrestin, GRK, phosphorylation; HET: TPO, SEP, NAG; 3.013A {Enterobacteria phage RB55} Probab=54.43 E-value=1.7 Score=49.17 Aligned_cols=21 Identities=19% Similarity=0.278 Sum_probs=12.4 Template_Neff=10.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYA 664 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~ 664 (908) ....|.+..++..+.+...+- T Consensus 266 ~~~~C~~~~~l~~~~~~~s~~ 286 (906) T 5W0P_C 266 GPTGCNLQGFFATLGGEIALW 286 (906) T ss_pred CchHHHHHHHHHHHHHHHHHH Confidence 356788877766554443333 No 360 >5W0P_B T4 lysozyme-human rhodopsin-mouse visual arrestin; rhodopsin, GPCR, arrestin, GRK, phosphorylation; HET: SEP, NAG, TPO; 3.013A {Enterobacteria phage RB55} Probab=54.02 E-value=1.8 Score=49.07 Aligned_cols=23 Identities=22% Similarity=0.327 Sum_probs=13.4 Template_Neff=10.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAAL 666 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l 666 (908) ....|.+..++..+.+...+-.+ T Consensus 266 ~~~~C~~~~~l~~~~~~~s~~~l 288 (906) T 5W0P_B 266 GPTGCNLQGFFATLGGEIALWSL 288 (906) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHH T ss_pred cchHHHHHHHHHHHHHHHHHHHH Confidence 35678887776665544433333 No 361 >6OSA_R Neurotensin receptor type 1, JMV449; GPCR, G-protein, complex, SIGNALING PROTEIN;{Homo sapiens} Probab=53.46 E-value=1.8 Score=43.48 Aligned_cols=16 Identities=6% Similarity=-0.145 Sum_probs=9.8 Template_Neff=12.000 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..+++. T Consensus 158 ~~~c~~~~~~~~~~~~ 173 (435) T 6OSA_R 158 DAGCRGYYFLRDACTY 173 (435) T ss_pred HHHHHHHHHHHHHHHH Confidence 5678777666554443 No 362 >4U14_A Muscarinic acetylcholine receptor M3,Endolysin fusion; alpha helix, G protein-coupled receptors; HET: 0HK; 3.57A {Rattus norvegicus} Probab=52.86 E-value=1.9 Score=43.86 Aligned_cols=22 Identities=9% Similarity=0.028 Sum_probs=12.9 Template_Neff=11.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAA 665 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~ 665 (908) ....|.+..++..++.....-. T Consensus 81 ~~~~C~~~~~~~~~~~~~s~~~ 102 (460) T 4U14_A 81 GNLACDLWLSIDYVASNASVMN 102 (460) T ss_dssp HHHHHHHHHHHHHHHHHHHHHH T ss_pred CccHHHHHHHHHHHHHHHHHHH Confidence 3677888777666554433333 No 363 >5TUD_A Chimera protein of 5-hydroxytryptamine receptor; 7-TM, GPCR, Fab, complex, SIGNALING; HET: ERM; 3.0A {Homo sapiens} Probab=52.52 E-value=1.9 Score=43.67 Aligned_cols=34 Identities=18% Similarity=0.025 Sum_probs=17.1 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..+......-.++ .=.-|...+. T Consensus 115 ~~~~C~~~~~~~~~~~~~s~~~~~~iaidR~~~i~ 149 (457) T 5TUD_A 115 PLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIK 149 (457) T ss_dssp CTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 356788877766544433333322 2334444443 No 364 >6C1R_B C5a anaphylatoxin chemotactic receptor 1; GPCR, MEMBRANE PROTEIN-INHIBITOR complex; HET: OLA, MLI, ZAL, EFD, OLC, YCM; 2.2A {Escherichia coli} Probab=52.18 E-value=2 Score=43.13 Aligned_cols=34 Identities=26% Similarity=0.328 Sum_probs=17.0 Template_Neff=11.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+++....-.+++ -..|...+. T Consensus 191 ~~~~C~~~~~~~~~~~~~s~~~~~~is~~R~~~i~ 225 (422) T 6C1R_B 191 GGAACSILPSLILLNMYASILLLATISADRFLLVF 225 (422) T ss_dssp CHHHHHHGGGHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 3567887777665544433333333 233444443 No 365 >6OL9_A Muscarinic acetylcholine receptor M5, T4; GPCR inhibitor complex, MEMBRANE PROTEIN; HET: P33, 0HK, OLA, OLC; 2.541A {Homo sapiens} Probab=52.11 E-value=2 Score=44.03 Aligned_cols=16 Identities=6% Similarity=0.185 Sum_probs=10.0 Template_Neff=11.600 Q NP_000836.2 644 DTIICSFRRVFLGLGM 659 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf 659 (908) ....|.+..++..++. T Consensus 81 ~~~~C~~~~~~~~~~~ 96 (480) T 6OL9_A 81 GSLACDLWLALDYVAS 96 (480) T ss_dssp CHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHH Confidence 3567887776655444 No 366 >6LI0_A G-protein coupled receptor 52,Flavodoxin,G-protein coupled; Human GPR52 receptor, Class A; HET: FMN, FLC, OLC, EN6, PEG; 2.2A {Homo sapiens} Probab=52.05 E-value=2 Score=43.78 Aligned_cols=34 Identities=15% Similarity=0.198 Sum_probs=17.0 Template_Neff=11.800 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..+.+....-.++ .=.-|.+.+. T Consensus 95 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 129 (468) T 6LI0_A 95 ESLTCQVFGYIISVLKSVSMWCLACISVDRYLAIT 129 (468) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred cchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 466788877765544433333332 2333444443 No 367 >4XES_A neurotensin receptor subtype 1, lysozyme; membrane protein, G protein-coupled receptor; HET: PEG, GOL, CIT, EPE; 2.6A {Rattus norvegicus} Probab=51.22 E-value=2.1 Score=44.65 Aligned_cols=33 Identities=9% Similarity=-0.048 Sum_probs=16.5 Template_Neff=11.800 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ...|.+..++..+.+....-.+++ -.-|...+. T Consensus 107 ~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 140 (541) T 4XES_A 107 DAGCRGYYFLRDACTYATALNVASLSVARYLAIC 140 (541) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 567887776665544433333332 233444443 No 368 >6C1Q_B C5a anaphylatoxin chemotactic receptor 1; GPCR, MEMBRANE PROTEIN; HET: 9P2, YCM, ZAL; 2.9A {Escherichia coli} Probab=50.95 E-value=2.1 Score=42.87 Aligned_cols=34 Identities=26% Similarity=0.328 Sum_probs=16.9 Template_Neff=11.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+++....-.+++ -..|...+. T Consensus 191 ~~~~C~~~~~~~~~~~~~s~~~~~~is~~R~~~i~ 225 (422) T 6C1Q_B 191 GGAACSILPSLILLNMYASILLLATISADRFLLVF 225 (422) T ss_pred cHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhh Confidence 3567887777665544433333333 233444443 No 369 >3V2Y_A Sphingosine 1-phosphate receptor 1, Lysozyme; sphingosine, EDG receptor, lipid receptor; HET: NAG, ML5; 2.8A {Homo sapiens, Enterobacteria phage T4} Probab=50.54 E-value=2.2 Score=44.40 Aligned_cols=33 Identities=15% Similarity=0.082 Sum_probs=16.0 Template_Neff=11.000 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ...|.+..++..++.....-.+++= .-|.+.+. T Consensus 132 ~~~c~~~~~~~~~~~~~s~~~l~~iaidRy~aI~ 165 (520) T 3V2Y_A 132 PAQWFLREGSMFVALSASVFSLLAIAIERYITML 165 (520) T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 4678777766554444333333332 23444443 No 370 >5UIW_A C-C chemokine receptor type 5,Rubredoxin,C-C; G-protein coupled receptor, Chemokine receptor; HET: OLC, OLA; 2.204A {Homo sapiens} Probab=50.33 E-value=2.2 Score=42.19 Aligned_cols=19 Identities=11% Similarity=0.266 Sum_probs=11.5 Template_Neff=12.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFS 662 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~ 662 (908) ....|.+..++..+++... T Consensus 99 ~~~~c~~~~~~~~~~~~~s 117 (411) T 5UIW_A 99 GNTMCQLLTGLYFIGFFSG 117 (411) T ss_dssp HHHHHHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHHHH Confidence 3567887777665544433 No 371 >5OLZ_A Adenosine receptor A2a,Soluble cytochrome b562,Adenosine; G-Protein Coupled Receptor, Adenosine 2a; HET: TAR, CLR, OLA, T4E, OLC, PGE; 1.9A {Homo sapiens} Probab=49.96 E-value=2.3 Score=42.63 Aligned_cols=16 Identities=19% Similarity=0.104 Sum_probs=9.3 Template_Neff=12.200 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..+... T Consensus 84 ~~~C~~~~~~~~~~~~ 99 (434) T 5OLZ_A 84 CHGCLFIACFVLVLAQ 99 (434) T ss_dssp HHHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHHHHHHH Confidence 5567776666554433 No 372 >6P9Y_R Guanine nucleotide-binding protein G(s) subunit; GPCR, MEMBRANE PROTEIN;{Homo sapiens} Probab=49.66 E-value=2.3 Score=43.79 Aligned_cols=30 Identities=20% Similarity=0.252 Sum_probs=18.4 Template_Neff=9.900 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTKTNRIH 674 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~ 674 (908) ...|.+..++...+....+..+++-.+-.+ T Consensus 219 ~~~C~~~~~~~~~~~~~s~~wl~~iai~ry 248 (483) T 6P9Y_R 219 TVECKAVMVFFHYCVVSNYFWLFIEGLYLF 248 (483) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 578888877766665555555555444333 No 373 >6MXT_A Fusion protein of Lysozyme and; G protein-coupled receptor, adrenergic receptor; HET: OLA, K5Y, OLC, P33, HTO, YCM; 2.95934213525A {Enterobacteria phage T4} Probab=49.35 E-value=2.4 Score=43.36 Aligned_cols=34 Identities=21% Similarity=0.215 Sum_probs=16.6 Template_Neff=11.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..++....+-.+++ =.-|...+. T Consensus 237 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 271 (472) T 6MXT_A 237 GNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAIT 271 (472) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 3567877776655444333333322 234444443 No 374 >6KUX_A alpha2A adrenergic receptor; alpha2A adrenergic receptor, antagonist, GPCR; HET: E3F, PEG, FLC; 2.7A {Spodoptera frugiperda} Probab=48.92 E-value=2.4 Score=41.68 Aligned_cols=18 Identities=11% Similarity=-0.077 Sum_probs=11.3 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..++... T Consensus 83 ~~~~C~~~~~~~~~~~~~ 100 (395) T 6KUX_A 83 GKAWCEIYLALDVLFCTS 100 (395) T ss_dssp SHHHHHHHHHHHHHHHHH T ss_pred CchHHHHHHHHHHHHHHH Confidence 356788877766554443 No 375 >4U15_B M3-mT4L, Tiotropium; GPCR T4L Stabillized Crystallography, MEMBRANE; HET: OLC, TAR, 0HK, P6G; 2.8A {Rattus norvegicus} Probab=48.41 E-value=2.5 Score=42.07 Aligned_cols=18 Identities=6% Similarity=0.032 Sum_probs=11.3 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..+++.. T Consensus 81 ~~~~C~~~~~~~~~~~~~ 98 (418) T 4U15_B 81 GNLACDLWLSIDYVASNA 98 (418) T ss_dssp CSHHHHHHHHHHHHHHHH T ss_pred cccHHHHHHHHHHHHHHH Confidence 367788877766554443 No 376 >3EML_A Human Adenosine A2A receptor/T4 lysozyme; adenosine, caffeine, GPCR, membrane protein; HET: STE, ZMA, SO4; 2.6A {Homo sapiens, Enterobacteria phage T4, Homo sapiens} Probab=48.34 E-value=2.5 Score=43.30 Aligned_cols=15 Identities=20% Similarity=0.173 Sum_probs=9.0 Template_Neff=11.700 Q NP_000836.2 644 DTIICSFRRVFLGLG 658 (908) Q Consensus 644 ~~~~C~~~~~~~~~g 658 (908) ....|.+..++..+. T Consensus 88 ~~~~C~~~~~l~~~~ 102 (488) T 3EML_A 88 ACHGCLFIACFVLVL 102 (488) T ss_dssp CHHHHHHHHHHHHHH T ss_pred cchHHHHHHHHHHHH Confidence 356677776665443 No 377 >6ORV_RP Guanine nucleotide-binding protein G(s) subunit; G-coupled protein receptor, GPCR, non-peptide; HET: N2V; 3.0A {Homo sapiens} Probab=48.20 E-value=2.5 Score=43.60 Aligned_cols=34 Identities=15% Similarity=0.304 Sum_probs=20.6 Template_Neff=9.600 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if 677 (908) ....|.+..++........+.-+++-.+-+|... T Consensus 231 ~~~~C~~~~~~~~~~~~as~~wl~~~al~l~~~i 264 (491) T 6ORV_RP 231 DSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLL 264 (491) T ss_pred CcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3578888877766666555555555554444433 No 378 >3PBL_A D(3) dopamine receptor; Structural Genomics, PSI-2, PSI-Biology, Protein; HET: ETQ, MAL; 2.89A {Homo sapiens, Enterobacteria phage T4} Probab=47.84 E-value=2.6 Score=43.15 Aligned_cols=33 Identities=15% Similarity=0.089 Sum_probs=16.5 Template_Neff=11.500 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ...|.+..++..+......-.+++ =.-|.+.+. T Consensus 109 ~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 142 (481) T 3PBL_A 109 RICCDVFVTLDVMMCTASIWNLCAISIDRYTAVV 142 (481) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 567887776655444333333322 334444443 No 379 >6CMO_R Soluble cytochrome b562,Rhodopsin, Guanine nucleotide-binding; Rhodopsin G protein ; HET: NAG;{Escherichia coli} Probab=47.51 E-value=2.6 Score=42.94 Aligned_cols=34 Identities=18% Similarity=0.261 Sum_probs=17.3 Template_Neff=10.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+++....-.++. -.-|...+. T Consensus 246 ~~~~C~~~~~l~~~~~~~s~~~~~~isi~R~~ai~ 280 (463) T 6CMO_R 246 GPTGCNLQGFFATLGGEIALWSLVVLAIERYVVVC 280 (463) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CCchHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 3567888777666554433333332 233444443 No 380 >6B3J_R Guanine nucleotide-binding protein G(s) subunit; class B G protein-coupled receptor;{Homo sapiens} Probab=46.45 E-value=2.8 Score=43.23 Aligned_cols=34 Identities=15% Similarity=0.304 Sum_probs=20.6 Template_Neff=9.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if 677 (908) ....|.+..++........+.-+++-.+-+|+.. T Consensus 231 ~~~~C~~~~~~~~~~~las~~wl~~~al~l~~~i 264 (491) T 6B3J_R 231 DSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLL 264 (491) T ss_pred ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3578888877766666555555555554444433 No 381 >4LDE_A Lysozyme, Beta-2 adrenergic receptor (E.C.3.2.1.17); G protein coupled receptor, MEMBRANE; HET: P0G, 1WV; 2.79A {Enterobacteria phage T4, Homo sapiens} Probab=45.08 E-value=3 Score=42.41 Aligned_cols=33 Identities=21% Similarity=0.226 Sum_probs=16.8 Template_Neff=11.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRI 676 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~i 676 (908) ....|.+..++....+...+-.+++- ..|...+ T Consensus 251 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i 284 (469) T 4LDE_A 251 GNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAI 284 (469) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678877776655544333333332 3344443 No 382 >5WF5_A Human A2a adenosine receptor_T4L chimera; human A2a adenosine receptor, D52N; HET: OLC, UKA; 2.6A {Homo sapiens} Probab=44.86 E-value=3.1 Score=42.97 Aligned_cols=13 Identities=23% Similarity=0.319 Sum_probs=7.7 Template_Neff=10.900 Q NP_000836.2 645 TIICSFRRVFLGL 657 (908) Q Consensus 645 ~~~C~~~~~~~~~ 657 (908) ...|.+..++..+ T Consensus 105 ~~~C~~~~~l~~~ 117 (504) T 5WF5_A 105 CHGCLFIACFVLV 117 (504) T ss_dssp HHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHH Confidence 4567776665443 No 383 >2R4R_A Beta-2 adrenergic receptor, antibody for; transmembrane helix, G-protein coupled receptor; 3.4A {Mus musculus} Probab=44.84 E-value=3.1 Score=40.08 Aligned_cols=17 Identities=18% Similarity=0.247 Sum_probs=10.5 Template_Neff=12.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..++.. T Consensus 102 ~~~~c~~~~~~~~~~~~ 118 (365) T 2R4R_A 102 GNFWCEFWTSIDVLCVT 118 (365) T ss_pred hhHHHHHHHHHHHHHHH Confidence 35678777766554443 No 384 >5TGZ_A Cannabinoid receptor 1,Flavodoxin; Membrane protein, G protein-coupled receptor; HET: OLC, OLA, ZDG, FMN; 2.8A {Homo sapiens} Probab=44.78 E-value=3.1 Score=42.00 Aligned_cols=20 Identities=10% Similarity=0.353 Sum_probs=9.1 Template_Neff=11.700 Q NP_000836.2 585 VVPVFVAILGIIATTFVIVT 604 (908) Q Consensus 585 ~~~~~~~~~~i~~~~~~~~~ 604 (908) ++..++.++|++.-++++.. T Consensus 27 ~~~~~~~~~gi~~N~~vl~~ 46 (452) T 5TGZ_A 27 VLSLTLGTFTVLENLLVLCV 46 (452) T ss_pred HHHHHHHHHHHHHHHHHHHH Confidence 33444455555544444433 No 385 >3RZE_A Histamine H1 receptor/Lysozyme chimera; Structural Genomics, PSI-Biology, Membrane Protein; HET: PO4, D7V, 5EH, OLC; 3.1A {Homo sapiens, Enterobacteria phage T4} Probab=44.72 E-value=3.1 Score=42.02 Aligned_cols=18 Identities=11% Similarity=0.065 Sum_probs=11.4 Template_Neff=11.600 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..+++.. T Consensus 77 ~~~~C~~~~~l~~~~~~~ 94 (452) T 3RZE_A 77 GRPLCLFWLSMDYVASTA 94 (452) T ss_dssp HHHHHHHHHHHHHHHHHH T ss_pred CCcHHHHHHHHHHHHHHH Confidence 467888877766544433 No 386 >6MEO_B Envelope glycoprotein gp160, T-cell surface; HIV coreceptor, MEMBRANE PROTEIN; HET: NAG, TYS, MAN, A2G, BMA; 3.9A {Human immunodeficiency virus 1} Probab=44.70 E-value=3.1 Score=39.05 Aligned_cols=18 Identities=11% Similarity=0.274 Sum_probs=10.9 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|....++...++.. T Consensus 97 ~~~~c~~~~~~~~~~~~~ 114 (313) T 6MEO_B 97 GNTMCQLLTGLYFIGFFS 114 (313) T ss_pred cHHHHHHHHHHHHHHHHH Confidence 356788777665554443 No 387 >4ZUD_A Chimera protein of Soluble cytochrome; human Angiotensin Receptor AT1R, BRIL; HET: OLM; 2.8A {Escherichia coli} Probab=44.48 E-value=3.1 Score=41.07 Aligned_cols=22 Identities=9% Similarity=0.214 Sum_probs=12.9 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAA 665 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~ 665 (908) ....|.+..++..+++....-. T Consensus 192 ~~~~c~~~~~~~~~~~~~s~~~ 213 (410) T 4ZUD_A 192 GNYLCKIASASVSFNLYASVFL 213 (410) T ss_dssp CHHHHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHH Confidence 3567888777666554433333 No 388 >4IAR_A Chimera protein of human 5-hydroxytryptamine; ergotamine, Novel protein engineering, GPCR; HET: OLB, ERM; 2.7A {Homo sapiens, Escherichia coli} Probab=44.43 E-value=3.2 Score=40.86 Aligned_cols=17 Identities=12% Similarity=0.091 Sum_probs=10.8 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..++.. T Consensus 89 ~~~~C~~~~~~~~~~~~ 105 (401) T 4IAR_A 89 GQVVCDFWLSSDITCCT 105 (401) T ss_dssp HHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHH Confidence 36778887776554443 No 389 >6D26_A Prostaglandin D2 receptor 2, Endolysin; GPCR, MEMBRANE PROTEIN-ANTAGONIST complex; HET: PGE, SIN, OLA, SO4, FSY, YCM; 2.798A {Homo sapiens} Probab=44.14 E-value=3.2 Score=42.01 Aligned_cols=33 Identities=21% Similarity=0.243 Sum_probs=17.1 Template_Neff=12.100 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ...|.+..++..+......-.+++ =..|.+.+. T Consensus 102 ~~~C~~~~~~~~~~~~~s~~~~~~ia~~Ry~ai~ 135 (470) T 6D26_A 102 TTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVV 135 (470) T ss_dssp SHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 567888777665544433333333 334544444 No 390 >6D27_A Prostaglandin D2 receptor 2, Endolysin; GPCR, MEMBRANE PROTEIN-ANTAGONIST complex; HET: MES, PGE, OLA, FT4, SO4, YCM, PGO; 2.738A {Homo sapiens} Probab=44.14 E-value=3.2 Score=42.01 Aligned_cols=33 Identities=21% Similarity=0.243 Sum_probs=17.1 Template_Neff=12.100 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ...|.+..++..+......-.+++ =..|.+.+. T Consensus 102 ~~~C~~~~~~~~~~~~~s~~~~~~ia~~Ry~ai~ 135 (470) T 6D27_A 102 TTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVV 135 (470) T ss_dssp SHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 567888777665544433333333 334544444 No 391 >6A93_A 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562; MEMBRANE PROTEIN; HET: CLR, PLM, 1PE, 8NU; 3.0A {Homo sapiens} Probab=43.83 E-value=3.3 Score=40.22 Aligned_cols=18 Identities=11% Similarity=-0.027 Sum_probs=11.3 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..++... T Consensus 78 ~~~~C~~~~~~~~~~~~~ 95 (376) T 6A93_A 78 PSKLCAVWIYLDVLFSTA 95 (376) T ss_dssp CHHHHHHHHHHHHHHHHH T ss_pred ChhHHHHHHHHHHHHHHH Confidence 356788877766544443 No 392 >6A94_A 5-hydroxytryptamine receptor 2A,Human Serotonin Receptor; receptor, MEMBRANE PROTEIN; HET: PLM, 1PE, ZOT, CLR, A6L; 2.9A {Homo sapiens} Probab=43.83 E-value=3.3 Score=40.22 Aligned_cols=18 Identities=11% Similarity=-0.027 Sum_probs=11.3 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..++... T Consensus 78 ~~~~C~~~~~~~~~~~~~ 95 (376) T 6A94_A 78 PSKLCAVWIYLDVLFSTA 95 (376) T ss_dssp CTHHHHHHHHHHHHHHHH T ss_pred ChhHHHHHHHHHHHHHHH Confidence 356788877766544443 No 393 >4IAQ_A 5-hydroxytryptamine receptor 1B; dihydroergotamine, Novel protein engineering, GPCR; HET: 2GM; 2.8A {Homo sapiens, Escherichia coli} Probab=43.20 E-value=3.4 Score=40.64 Aligned_cols=18 Identities=11% Similarity=0.043 Sum_probs=11.3 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..++... T Consensus 89 ~~~~C~~~~~~~~~~~~~ 106 (403) T 4IAQ_A 89 GQVVCDFWLSSDITCCTA 106 (403) T ss_dssp HHHHHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHHH Confidence 356788877766554443 No 394 >6KPG_R Guanine nucleotide-binding protein G(i) subunit; GPCR, G protein, cryo-EM, MEMBRANE; HET: 8D0;{Homo sapiens} Probab=42.85 E-value=3.5 Score=41.88 Aligned_cols=18 Identities=6% Similarity=0.329 Sum_probs=8.0 Template_Neff=11.600 Q NP_000836.2 586 VPVFVAILGIIATTFVIV 603 (908) Q Consensus 586 ~~~~~~~~~i~~~~~~~~ 603 (908) +..+++++|++..++++. T Consensus 166 ~~~~~~~~gi~~N~l~i~ 183 (469) T 6KPG_R 166 LSLTLGTFTVLENLLVLC 183 (469) T ss_dssp HHHHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHHHhHHHHH Confidence 334444555544444333 No 395 >4MQS_A Muscarinic acetylcholine receptor M2, Nanobody; G protein-coupled receptor, Muscarinic acetylcholine; HET: IXO; 3.5A {Homo sapiens} Probab=42.44 E-value=3.5 Score=39.35 Aligned_cols=18 Identities=6% Similarity=0.071 Sum_probs=11.0 Template_Neff=12.600 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..+++.. T Consensus 109 ~~~~c~~~~~~~~~~~~~ 126 (351) T 4MQS_A 109 GPVVCDLWLALDYVVSNA 126 (351) T ss_pred ChhHHHHHHHHHHHHHHH Confidence 356787777665554443 No 396 >4DJH_B Kappa-type opioid receptor; JDtic, GPCR newtork, PSI-Biology, KOR; HET: JDC, OLC, CIT, PEG; 2.9A {Homo Sapiens} Probab=42.33 E-value=3.6 Score=41.85 Aligned_cols=19 Identities=16% Similarity=0.183 Sum_probs=11.6 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFS 662 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~ 662 (908) ....|.+..++..+++... T Consensus 90 ~~~~C~~~~~~~~~~~~~s 108 (480) T 4DJH_B 90 GDVLCKIVLSIDYYNMFTS 108 (480) T ss_dssp HHHHHHHHHHHHHHHHHHH T ss_pred cchHHHHHHHHHHHHHHHH Confidence 3567888777655544433 No 397 >6OS0_A Type-1 angiotensin II receptor,Soluble cytochrome; GPCR, nanobody, MEMBRANE PROTEIN; HET: NAG; 2.9A {Homo sapiens} Probab=42.32 E-value=3.6 Score=40.84 Aligned_cols=34 Identities=15% Similarity=0.222 Sum_probs=17.3 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAAL-LTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l-~~K~~ri~~if 677 (908) ....|.+..++..+++....-.+ +.=.-|...+. T Consensus 104 ~~~~C~~~~~~~~~~~~~s~~~~~~isi~R~~~i~ 138 (425) T 6OS0_A 104 GNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIV 138 (425) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35778887776655443333322 22334444443 No 398 >6OS1_A Type-1 angiotensin II receptor,Soluble cytochrome; GPCR, MEMBRANE PROTEIN; HET: CLR, OLC; 2.794A {Homo sapiens} Probab=42.32 E-value=3.6 Score=40.84 Aligned_cols=34 Identities=15% Similarity=0.222 Sum_probs=17.3 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAAL-LTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l-~~K~~ri~~if 677 (908) ....|.+..++..+++....-.+ +.=.-|...+. T Consensus 104 ~~~~C~~~~~~~~~~~~~s~~~~~~isi~R~~~i~ 138 (425) T 6OS1_A 104 GNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIV 138 (425) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35778887776655443333322 22334444443 No 399 >6OS2_A Type-1 angiotensin II receptor,Soluble cytochrome; GPCR, MEMBRANE PROTEIN; HET: CLR, OLC, NAG; 2.7A {Homo sapiens} Probab=42.32 E-value=3.6 Score=40.84 Aligned_cols=34 Identities=15% Similarity=0.222 Sum_probs=17.3 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAAL-LTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l-~~K~~ri~~if 677 (908) ....|.+..++..+++....-.+ +.=.-|...+. T Consensus 104 ~~~~C~~~~~~~~~~~~~s~~~~~~isi~R~~~i~ 138 (425) T 6OS2_A 104 GNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIV 138 (425) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35778887776655443333322 22334444443 No 400 >4YAY_A human Angiotensin Receptor_Bril Chimera; XFEL, Serial Femtosecond Crystallography, human; HET: ZD7; 2.9A {Escherichia coli} Probab=41.90 E-value=3.7 Score=40.60 Aligned_cols=25 Identities=12% Similarity=0.218 Sum_probs=14.7 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT 668 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~ 668 (908) ....|.+..++..+++...+..++. T Consensus 192 ~~~~c~~~~~~~~~~~~~s~~~~~~ 216 (414) T 4YAY_A 192 GNYLCKIASASVSFNLYASVFLLTC 216 (414) T ss_dssp TTHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888777766555444444433 No 401 >4N6H_A Soluble cytochrome b562, Delta-type opioid; human opioid receptor, sodium regulation; HET: OLA, PGE, TLA, OLC, EJ4; 1.8A {Escherichia coli, Homo sapiens} Probab=41.57 E-value=3.7 Score=40.64 Aligned_cols=34 Identities=15% Similarity=0.121 Sum_probs=16.7 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..+.+....-.++ .=..|...+. T Consensus 193 ~~~~C~~~~~~~~~~~~~s~~~~~~ia~~R~~~i~ 227 (414) T 4N6H_A 193 GELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVC 227 (414) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CchhHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 356788777665544433333222 2234544444 No 402 >6AKX_B Neuropeptide Y receptor type 1,T4; G Protein-Coupled Receptor Chemokine Receptor; HET: A4R; 2.8A {Homo sapiens} Probab=41.42 E-value=3.8 Score=39.78 Aligned_cols=22 Identities=9% Similarity=0.150 Sum_probs=12.8 Template_Neff=12.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAA 665 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~ 665 (908) ....|.+..++..+++....-. T Consensus 99 ~~~~c~~~~~~~~~~~~~s~~~ 120 (381) T 6AKX_B 99 GNTMCQLLTGLYFIGFFSGIFF 120 (381) T ss_dssp CHHHHHHHHHHHHHHHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHHHHH Confidence 3567887777665554443333 No 403 >6D9H_R Guanine nucleotide-binding protein G(i) subunit; signaling protein, membrane protein, active-state; HET: ADN;{Homo sapiens} Probab=40.77 E-value=3.9 Score=40.00 Aligned_cols=16 Identities=6% Similarity=-0.155 Sum_probs=9.4 Template_Neff=12.000 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..+.+. T Consensus 132 ~~~C~~~~~~~~~~~~ 147 (389) T 6D9H_R 132 FHTCLMVACPVLILTQ 147 (389) T ss_dssp HHHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHHHHHHH Confidence 4578777666554443 No 404 >6RZ4_A Cysteinyl leukotriene receptor 1,Soluble cytochrome; GPCR, LCP, MEMBRANE PROTEIN, cysteinyl; HET: KNT, OLC, OLA; 2.7A {Homo sapiens} Probab=39.89 E-value=4.1 Score=40.33 Aligned_cols=35 Identities=14% Similarity=0.081 Sum_probs=17.2 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYA-ALLTKTNRIHRIFE 678 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~-~l~~K~~ri~~if~ 678 (908) ....|.+..++..+......- .++.-.-|...+.+ T Consensus 95 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~~ 130 (423) T 6RZ4_A 95 GDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVF 130 (423) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC T ss_pred cccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC Confidence 366788877665544333222 22333345444443 No 405 >6RZ5_B Cysteinyl leukotriene receptor 1,Soluble cytochrome; GPCR, LCP, MEMBRANE PROTEIN, cysteinyl; HET: 1PE, ZLK, OLA, OLC; 2.53A {Homo sapiens} Probab=39.89 E-value=4.1 Score=40.33 Aligned_cols=35 Identities=14% Similarity=0.081 Sum_probs=17.2 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYA-ALLTKTNRIHRIFE 678 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~-~l~~K~~ri~~if~ 678 (908) ....|.+..++..+......- .++.-.-|...+.+ T Consensus 95 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~~ 130 (423) T 6RZ5_B 95 GDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVF 130 (423) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC T ss_pred cccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC Confidence 366788877665544333222 22333345444443 No 406 >5TVN_A 5-hydroxytryptamine receptor 2B,Soluble cytochrome b562,5-hydroxytryptamine; LSD, GPCR, serotonin receptor, MEMBRANE; HET: 7LD, OLC, CLR; 2.9A {Homo sapiens} Probab=39.86 E-value=4.1 Score=39.89 Aligned_cols=34 Identities=18% Similarity=0.015 Sum_probs=17.3 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..++.....-.+++= .-|...+. T Consensus 84 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 118 (402) T 5TVN_A 84 PLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIK 118 (402) T ss_dssp CSTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CccchhHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678887776655444333333332 23444443 No 407 >5UZ7_R Guanine nucleotide-binding protein G(s) subunit; Class B G protein-coupled receptor; 4.1A {Homo sapiens} Probab=39.51 E-value=4.3 Score=41.89 Aligned_cols=27 Identities=19% Similarity=0.292 Sum_probs=15.2 Template_Neff=10.000 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTKTN 671 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K~~ 671 (908) ...|.+..++..+.....+..+++-++ T Consensus 224 ~~~C~~~~~l~~~~~~~s~~wl~~iai 250 (501) T 5UZ7_R 224 PVSCKILHFFHQYMMACNYFWMLCEGI 250 (501) T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 467887776665554444444444443 No 408 >6I9K_A Kumopsin1; Rhodopsin, GPCR, Light-sensitive, Retinal, MEMBRANE; HET: RET, OLC; 2.145A {Hasarius adansoni} Probab=38.98 E-value=4.4 Score=39.30 Aligned_cols=17 Identities=12% Similarity=0.123 Sum_probs=10.3 Template_Neff=12.400 Q NP_000836.2 645 TIICSFRRVFLGLGMCF 661 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l 661 (908) ...|.+..++..+++.. T Consensus 120 ~~~c~~~~~~~~~~~~~ 136 (380) T 6I9K_A 120 PFMCELYGMIGSLFGSA 136 (380) T ss_pred HHHHHHHHHHHHHHHHH Confidence 56787776665554433 No 409 >4XNV_A P2Y purinoceptor 1, Rubredoxin; human P2Y1 receptor, G protein; HET: CLR, BUR, 1PE, OLC, Y01; 2.2A {Homo sapiens} Probab=38.66 E-value=4.5 Score=40.04 Aligned_cols=33 Identities=15% Similarity=0.288 Sum_probs=16.8 Template_Neff=12.200 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ...|.+..++..+++....-.+++- .-|...+. T Consensus 120 ~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 153 (421) T 4XNV_A 120 DAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVV 153 (421) T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 5678887776665544333333332 33444443 No 410 >4XNW_C P2Y purinoceptor 1, Rubredoxin; human P2Y1 receptor, G protein; HET: 2ID; 2.7A {Homo sapiens} Probab=38.66 E-value=4.5 Score=40.04 Aligned_cols=33 Identities=15% Similarity=0.288 Sum_probs=16.8 Template_Neff=12.200 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ...|.+..++..+++....-.+++- .-|...+. T Consensus 120 ~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 153 (421) T 4XNW_C 120 DAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVV 153 (421) T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 5678887776665544333333332 33444443 No 411 >5WB1_A Envelope protein US28,nanobody 7; chemokine receptor, MEMBRANE PROTEIN; 3.508A {Human cytomegalovirus} Probab=38.12 E-value=4.6 Score=40.62 Aligned_cols=34 Identities=15% Similarity=0.208 Sum_probs=17.1 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+++...+-.++.- .-|...+. T Consensus 108 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 142 (458) T 5WB1_A 108 ASVPCTLLTACFYVAMFASLCFITEIALDRYYAIV 142 (458) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred cchhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678877666555444433333332 33444443 No 412 >6LI1_A G-protein coupled receptor 52,Flavodoxin,G-protein coupled; Human GPR52 receptor, Class A; HET: PGE, OLC, FMN; 2.9A {Homo sapiens} Probab=38.11 E-value=4.6 Score=40.55 Aligned_cols=34 Identities=15% Similarity=0.199 Sum_probs=17.9 Template_Neff=11.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..++.....-.+++ =.-|.+.+. T Consensus 95 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 129 (449) T 6LI1_A 95 ESLTCQVFGYIISVLKSVSMWCLACISVDRYLAIT 129 (449) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 4677888777665544433333333 334444444 No 413 >5UNG_B Soluble cytochrome b562,Type-2 angiotensin II; human Angiotensin II receptor complex; HET: OLC, OLA, 8ES; 2.8A {Escherichia coli} Probab=38.07 E-value=4.6 Score=39.71 Aligned_cols=33 Identities=21% Similarity=0.351 Sum_probs=17.1 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRI 676 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~i 676 (908) ....|.+..++..+++....-.++.- ..|...+ T Consensus 189 ~~~~c~~~~~~~~~~~~~s~~~~~~ia~~R~~~i 222 (411) T 5UNG_B 189 GPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSV 222 (411) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678887776665554433333332 2344443 No 414 >5UNF_A Soluble cytochrome b562,Type-2 angiotensin II; human Angiotensin II receptor complex; HET: 8ES; 2.8A {Escherichia coli} Probab=37.89 E-value=4.7 Score=39.75 Aligned_cols=25 Identities=24% Similarity=0.344 Sum_probs=14.0 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT 668 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~ 668 (908) ....|.+..++..+++....-.++. T Consensus 189 ~~~~c~~~~~~~~~~~~~s~~~~~~ 213 (411) T 5UNF_A 189 GPVMCKVFGSFLTLNMFASIFFITC 213 (411) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567887777666555444333333 No 415 >6J21_A Substance-P receptor (E.C.3.2.1.17),Endolysin; GPCR, Complex, Antagonist, signalling protein; HET: GBQ, OLC; 3.2A {Homo sapiens} Probab=37.85 E-value=4.7 Score=40.12 Aligned_cols=34 Identities=18% Similarity=0.236 Sum_probs=16.7 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..++.....-.++ .=.-|...+. T Consensus 100 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~Ry~~i~ 134 (441) T 6J21_A 100 GLFYCKFHNFFPIAAVFASIWSMTAVAFDRYMAII 134 (441) T ss_pred cchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 356788877665544433332222 2334444443 No 416 >5ZHP_A Muscarinic acetylcholine receptor M3,Lysozyme,Muscarinic acetylcholine; G protein coupled receptor, MEMBRANE; HET: MAL, CIT, PG4, 9EC, P6G; 3.1A {Rattus norvegicus} Probab=37.68 E-value=4.7 Score=39.82 Aligned_cols=17 Identities=6% Similarity=0.079 Sum_probs=10.5 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..+... T Consensus 81 ~~~~C~~~~~~~~~~~~ 97 (418) T 5ZHP_A 81 GNLACDLWLSIDYVASN 97 (418) T ss_dssp CHHHHHHHHHHHHHHHH T ss_pred cccHHHHHHHHHHHHHH Confidence 35678877776554443 No 417 >5NJ6_A Lysozyme,Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated; MEMBRANE PROTEIN, GPCR, 7TM; 4.0A {Homo sapiens} Probab=37.61 E-value=4.7 Score=40.08 Aligned_cols=34 Identities=21% Similarity=0.221 Sum_probs=16.8 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+......-.+++ =.-|...+. T Consensus 91 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 125 (437) T 5NJ6_A 91 GEALCNVLIGFFYANMYCSILFLTCLSVQRAWEIV 125 (437) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888776655544333333322 333444443 No 418 >5DSG_B Muscarinic acetylcholine receptor M4,Endolysin,Muscarinic acetylcholine; Membrane, GPCR, Signaling, Antagonist, MEMBRANE; HET: P6G, OLC, 0HK, PG6, EDT, OLA; 2.6A {Homo sapiens} Probab=37.28 E-value=4.8 Score=39.81 Aligned_cols=17 Identities=6% Similarity=0.130 Sum_probs=10.4 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..+++. T Consensus 82 ~~~~C~~~~~~~~~~~~ 98 (422) T 5DSG_B 82 GAVVCDLWLALDYVVSN 98 (422) T ss_dssp HHHHHHHHHHHHHHHHH T ss_pred cHHHHHHHHHHHHHHHH Confidence 36678877776554443 No 419 >4Z36_A Lysophosphatidic Acid Receptor 1, cytochrome; human lysophosphatidic acid receptor 1; HET: 1WV, ON3; 2.9A {Homo sapiens} Probab=37.22 E-value=4.9 Score=40.64 Aligned_cols=34 Identities=15% Similarity=0.156 Sum_probs=15.9 Template_Neff=11.200 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSY-AALLTKTNRIHRIFE 678 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~-~~l~~K~~ri~~if~ 678 (908) ...|.+..++..+...... ..++.-.-|.+.+.+ T Consensus 136 ~~~c~~~~~l~~~~~~~s~~~l~~isidRy~aI~~ 170 (459) T 4Z36_A 136 VSTWLLRQGLIDTSLTASVANLLAIAIERHITVFR 170 (459) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHc Confidence 4578777666554333222 222233345544443 No 420 >6PT0_R Cannabinoid receptor 2, Guanine nucleotide-binding; GPCR complex, WIN55, 212-2, MEMBRANE; HET: WI5, CLR, PLM; 3.2A {Homo sapiens} Probab=36.97 E-value=4.9 Score=38.72 Aligned_cols=12 Identities=0% Similarity=-0.097 Sum_probs=5.9 Template_Neff=12.300 Q NP_000836.2 645 TIICSFRRVFLG 656 (908) Q Consensus 645 ~~~C~~~~~~~~ 656 (908) ...|....++.. T Consensus 103 ~~~~~~~~~~~~ 114 (369) T 6PT0_R 103 KAVFLLKIGSVT 114 (369) T ss_dssp HHHHHHHHHHHH T ss_pred HHHHHHHHHHHH Confidence 445655554443 No 421 >6OIJ_R Guanine nucleotide-binding protein G(i) subunit; G-protein coupled receptor-G-protein complex, neurotransmitter; HET: Y01, IXO; 3.3A {Homo sapiens} Probab=36.53 E-value=5.1 Score=38.43 Aligned_cols=34 Identities=18% Similarity=0.165 Sum_probs=16.6 Template_Neff=12.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+++....-.++. -.-|...+. T Consensus 103 ~~~~c~~~~~~~~~~~~~s~~~~~~i~~~R~~~i~ 137 (363) T 6OIJ_R 103 GTLACDLWLALDYVASQASVMNLLLISFDRYFSVT 137 (363) T ss_pred cchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567877766655444433333322 233444444 No 422 >4Z35_A Lysophosphatidic Acid Receptor 1, cytochrome; human lysophosphatidic acid receptor 1; HET: ON9, 1WV; 2.9A {Homo sapiens} Probab=36.39 E-value=5.1 Score=40.54 Aligned_cols=14 Identities=7% Similarity=0.083 Sum_probs=8.0 Template_Neff=11.200 Q NP_000836.2 645 TIICSFRRVFLGLG 658 (908) Q Consensus 645 ~~~C~~~~~~~~~g 658 (908) ...|.+..++..++ T Consensus 136 ~~~c~~~~~l~~~~ 149 (464) T 4Z35_A 136 VSTWLLRQGLIDTS 149 (464) T ss_pred HHHHHHHHHHHHHH Confidence 45677666554443 No 423 >6KR8_A beta 2 adrenergic receptor; G-protein coupled receptor, b2AR, full; NMR {Homo sapiens} Probab=36.37 E-value=5.1 Score=37.80 Aligned_cols=34 Identities=21% Similarity=0.187 Sum_probs=16.9 Template_Neff=12.600 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..+++....-.++ .-..|...+. T Consensus 79 ~~~~c~~~~~~~~~~~~~s~~~~~~ia~~R~~~i~ 113 (336) T 6KR8_A 79 GNFWCEFWTSIDVLCVTASIWTLCVIAVDRYFAIC 113 (336) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCC T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhh Confidence 356788777766554433333222 2334444443 No 424 >6IIU_A Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane; GPCR, Complex, Antagonist, SIGNALING PROTEIN; HET: CLR, A8X, OLC; 2.5A {Escherichia coli} Probab=36.22 E-value=5.2 Score=40.63 Aligned_cols=24 Identities=4% Similarity=0.173 Sum_probs=11.7 Template_Neff=11.800 Q NP_000836.2 585 VVPVFVAILGIIATTFVIVTFVRY 608 (908) Q Consensus 585 ~~~~~~~~~~i~~~~~~~~~~~~~ 608 (908) ++..++.++|++..++.++.+... T Consensus 136 ~~~~~~~~lgi~~N~~~l~~~~~~ 159 (484) T 6IIU_A 136 WFAASFCVVGLASNLLALSVLAGA 159 (484) T ss_pred HHHHHHHHHHHHHHHHHHHHHHcc Confidence 444455555655554444444433 No 425 >6IIV_A Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane; GPCR, Complex, Antagonist, SIGNALING PROTEIN; HET: CLR, A90; 3.0A {Escherichia coli} Probab=36.22 E-value=5.2 Score=40.63 Aligned_cols=24 Identities=4% Similarity=0.173 Sum_probs=11.7 Template_Neff=11.800 Q NP_000836.2 585 VVPVFVAILGIIATTFVIVTFVRY 608 (908) Q Consensus 585 ~~~~~~~~~~i~~~~~~~~~~~~~ 608 (908) ++..++.++|++..++.++.+... T Consensus 136 ~~~~~~~~lgi~~N~~~l~~~~~~ 159 (484) T 6IIV_A 136 WFAASFCVVGLASNLLALSVLAGA 159 (484) T ss_pred HHHHHHHHHHHHHHHHHHHHHHcc Confidence 444455555655554444444433 No 426 >6E3Y_R Calcitonin gene-related peptide 1, Nanobody; class B G protein-coupled receptor; 3.3A {Lama glama} Probab=36.12 E-value=5.2 Score=41.00 Aligned_cols=25 Identities=16% Similarity=0.236 Sum_probs=13.8 Template_Neff=10.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT 668 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~ 668 (908) ....|.+..++..+.....+.-+++ T Consensus 218 ~~~~C~~~~~l~~~~~~as~~wl~~ 242 (490) T 6E3Y_R 218 NPVSCKVSQFIHLYLMGCNYFWMLC 242 (490) T ss_dssp CCHHHHHHHHHHHHHHHHHHHHHHH T ss_pred ChHHHHHHHHHHHHHHHHHHHHHHH Confidence 3577887776655544443333333 No 427 >6UUN_R Guanine nucleotide-binding protein G(s) subunit; GPCR, adrenomedullin receptor complex, MEMBRANE;{Homo sapiens} Probab=36.12 E-value=5.2 Score=41.00 Aligned_cols=25 Identities=16% Similarity=0.236 Sum_probs=13.8 Template_Neff=10.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT 668 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~ 668 (908) ....|.+..++..+.....+.-+++ T Consensus 218 ~~~~C~~~~~l~~~~~~as~~wl~~ 242 (490) T 6UUN_R 218 NPVSCKVSQFIHLYLMGCNYFWMLC 242 (490) T ss_dssp CCHHHHHHHHHHHHHHHHHHHHHHH T ss_pred ChHHHHHHHHHHHHHHHHHHHHHHH Confidence 3577887776655544443333333 No 428 >6M1I_A Ribonuclease 3 (E.C.3.1.26.3), Microprocessor complex; GPCR, PROTEIN BINDING; 3.5A {Homo sapiens} Probab=35.51 E-value=5.4 Score=39.54 Aligned_cols=28 Identities=21% Similarity=0.265 Sum_probs=17.2 Template_Neff=10.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTN 671 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ 671 (908) ....|.+..++..++....+..+++-++ T Consensus 184 ~~~~C~~~~~~~~~~~~~s~~~l~~ia~ 211 (406) T 6M1I_A 184 STVECKAVMVFFHYCVVSNYFWLFIEGL 211 (406) T ss_dssp CCSHHHHHHHHHHHHHHTTTTTTHHHHH T ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3578888877766655555555554443 No 429 >4XT1_A US28, CX3CL1, nanobody 7; GPCR, chemokine, membrane protein, complex; HET: CLR, UNL, OLC; 2.886A {Cytomegalovirus} Probab=35.42 E-value=5.4 Score=38.30 Aligned_cols=35 Identities=14% Similarity=0.192 Sum_probs=17.1 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIFE 678 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if~ 678 (908) ....|.+..++...++....-.++. -.-|...+.+ T Consensus 108 ~~~~C~~~~~~~~~~~~~s~~~~~~i~~~R~~~i~~ 143 (362) T 4XT1_A 108 ASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVY 143 (362) T ss_dssp -CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTS T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHc Confidence 3567877766655444433333332 3345444443 No 430 >6LW5_A N-formyl peptide receptor 2,Soluble cytochrome; Formyl peptide receptor, G protein-coupled; HET: CLR; 2.8A {Escherichia coli} Probab=35.22 E-value=5.5 Score=39.58 Aligned_cols=18 Identities=11% Similarity=0.361 Sum_probs=10.6 Template_Neff=11.700 Q NP_000836.2 645 TIICSFRRVFLGLGMCFS 662 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~ 662 (908) ...|.+..++..+++... T Consensus 200 ~~~C~~~~~~~~~~~~~s 217 (427) T 6LW5_A 200 WFLCKLIHIVVDINLFGS 217 (427) T ss_dssp HHHHHHHHHHHHHHHHHH T ss_pred ccHHHHHHHHHHHHHHHH Confidence 456877776655444433 No 431 >5VBL_B agonist peptide,Rubredoxin-Apelin receptor chimera; human apelin receptor complex, agonist; HET: ALC, OLC, 200, HRG, OIC; 2.6A {Homo sapiens} Probab=34.87 E-value=5.6 Score=39.04 Aligned_cols=34 Identities=21% Similarity=0.230 Sum_probs=17.0 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+.+....-.++.- .-|...+. T Consensus 116 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 150 (407) T 5VBL_B 116 GTFFCKLSSYLIFVNMYASAFCLTGLSFDRYLAIV 150 (407) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred cchhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678887766655444333333332 33444443 No 432 >5V54_B OB-1 fused 5-HT1b receptor; 5-hydroxytryptamine, GPCR antagonist, OB1, ELECTRON; HET: 89F; 3.9A {Homo sapiens} Probab=34.66 E-value=5.7 Score=38.71 Aligned_cols=34 Identities=18% Similarity=0.068 Sum_probs=16.9 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..++.....-.+++ =.-|...+. T Consensus 82 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 116 (395) T 5V54_B 82 GQVVCDFWLSSDITCCTASIWHLCVIALDRYWAIT 116 (395) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTT T ss_pred chhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888777655444333333333 233444443 No 433 >5WB2_A Envelope protein US28,nanobody 7, CX3CL1; chemokine receptor, engineered proteins, MEMBRANE; HET: YCM, MES, CLR, OLC; 3.5A {Human cytomegalovirus} Probab=34.21 E-value=5.8 Score=39.81 Aligned_cols=34 Identities=15% Similarity=0.208 Sum_probs=17.1 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+++....-.++.- .-|...+. T Consensus 107 ~~~~C~~~~~~~~~~~~~s~~~~~~ia~~R~~~i~ 141 (460) T 5WB2_A 107 ASVPCTLLTACFYVAMFASLCFITEIALDRYYAIV 141 (460) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred cchHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHH Confidence 35678877766655444333333332 33444443 No 434 >6IBB_A Succinate receptor 1, Nanobody6; SUCNR1 GPR91 GPCR G-Protein coupled; HET: GOL, OLC, CLR, H95; 2.12A {Rattus norvegicus} Probab=33.17 E-value=6.2 Score=37.34 Aligned_cols=34 Identities=18% Similarity=0.179 Sum_probs=17.1 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++....+....-.++. -..|...+. T Consensus 94 ~~~~c~~~~~~~~~~~~~s~~~~~~ia~~R~~~i~ 128 (342) T 6IBB_A 94 GDVLCISNRYVLHANLYTSILFLTFISIDRYLLMK 128 (342) T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567887776665544333333333 234444443 No 435 >4GBR_A Beta-2 adrenergic receptor, Lysozyme (E.C.3.2.1.17); 7 transmembrane helices, G-protein coupled; HET: CAU; 3.993A {Homo sapiens} Probab=32.99 E-value=6.3 Score=36.36 Aligned_cols=17 Identities=18% Similarity=0.247 Sum_probs=10.3 Template_Neff=12.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|....++...+.. T Consensus 74 ~~~~c~~~~~~~~~~~~ 90 (309) T 4GBR_A 74 GNFWCEFWTSIDVLCVT 90 (309) T ss_pred chhHHHHHHHHHHHHHH Confidence 35678777766554443 No 436 >6NBF_R Parathyroid hormone/parathyroid hormone-related peptide receptor; Parathyroid hormone receptor, GPCR, Class; HET: CLR, PLM; 3.0A {Homo sapiens} Probab=32.16 E-value=6.7 Score=40.00 Aligned_cols=29 Identities=17% Similarity=0.206 Sum_probs=17.2 Template_Neff=9.800 Q NP_000836.2 646 IICSFRRVFLGLGMCFSYAALLTKTNRIH 674 (908) Q Consensus 646 ~~C~~~~~~~~~gf~l~~~~l~~K~~ri~ 674 (908) ..|.+...+...+....+.-+++-.+-.| T Consensus 253 ~~C~~~~~l~~~~~~~s~~wl~~~al~~~ 281 (478) T 6NBF_R 253 AGCRVAVTFFLYFLATNYYWILVEGLYLH 281 (478) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 67888777766665555555555444333 No 437 >6NBH_R Parathyroid hormone/parathyroid hormone-related peptide receptor; Parathyroid hormone receptor, GPCR, Class; HET: CLR, PLM; 3.5A {Homo sapiens} Probab=32.16 E-value=6.7 Score=40.00 Aligned_cols=29 Identities=17% Similarity=0.206 Sum_probs=17.2 Template_Neff=9.800 Q NP_000836.2 646 IICSFRRVFLGLGMCFSYAALLTKTNRIH 674 (908) Q Consensus 646 ~~C~~~~~~~~~gf~l~~~~l~~K~~ri~ 674 (908) ..|.+...+...+....+.-+++-.+-.| T Consensus 253 ~~C~~~~~l~~~~~~~s~~wl~~~al~~~ 281 (478) T 6NBH_R 253 AGCRVAVTFFLYFLATNYYWILVEGLYLH 281 (478) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 67888777766665555555555444333 No 438 >6LML_R Guanine nucleotide-binding protein G(i) subunit; glucagon receptor, GPCR, Gi1 protein;{Homo sapiens} Probab=31.93 E-value=6.8 Score=39.09 Aligned_cols=34 Identities=24% Similarity=0.451 Sum_probs=22.0 Template_Neff=10.300 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFE 678 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if~ 678 (908) ...|.+..++........+.-+++-.+-+++.+. T Consensus 195 ~~~C~~~~~~~~~~~~~s~~w~~~~~~~l~~~i~ 228 (422) T 6LML_R 195 VAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLG 228 (422) T ss_dssp CTHHHHHHHHHHHHTTTTTTHHHHHHHHHHHHTT T ss_pred hhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 4788888777776666666666665555555443 No 439 >6WHC_R Guanine nucleotide-binding protein G(s) subunit; GPCR, receptor complex, MEMBRANE PROTEIN;{Homo sapiens} Probab=31.83 E-value=6.8 Score=39.91 Aligned_cols=34 Identities=24% Similarity=0.451 Sum_probs=22.5 Template_Neff=9.900 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFE 678 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if~ 678 (908) ...|.+..++........+.-+++-.+-+|+... T Consensus 221 ~~~C~~~~~~~~~~~~~s~~wl~~~~l~l~~~i~ 254 (477) T 6WHC_R 221 VAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLG 254 (477) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3688888877777666666666666655555443 No 440 >6LI2_A G-protein coupled receptor 52,Rubredoxin,G-protein coupled; Human GPR52 receptor, Class A; HET: OLC; 2.8A {Homo sapiens} Probab=31.69 E-value=6.8 Score=37.61 Aligned_cols=34 Identities=15% Similarity=0.199 Sum_probs=17.6 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+.+....-.++. =.-|...+. T Consensus 95 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 129 (372) T 6LI2_A 95 ESLTCQVFGYIISVLKSVSMWCLACISVDRYLAIT 129 (372) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhh Confidence 3567888777766544433333333 334444444 No 441 >4L6R_A Soluble cytochrome b562 and Glucagon; Human glucagon receptor, diabetes, GPCR; 3.3A {Escherichia coli, Homo sapiens} Probab=31.23 E-value=7.1 Score=38.95 Aligned_cols=34 Identities=24% Similarity=0.451 Sum_probs=21.3 Template_Neff=10.500 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFE 678 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if~ 678 (908) ...|.+..++..++....+.-+++-.+-++..+. T Consensus 205 ~~~C~~~~~~~~~~~las~~w~~~i~~~~~~~~~ 238 (425) T 4L6R_A 205 VAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLG 238 (425) T ss_pred ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 5678887777766665555555555555555444 No 442 >6KUW_A Alpha-2C adrenergic receptor; Alpha2c adrenergic receptor, antagonist, GPCR; HET: OLC, OLA, CLR, E33; 2.8A {Homo sapiens} Probab=31.07 E-value=7.1 Score=39.70 Aligned_cols=17 Identities=12% Similarity=-0.062 Sum_probs=10.6 Template_Neff=11.600 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..+... T Consensus 92 ~~~~C~~~~~~~~~~~~ 108 (496) T 6KUW_A 92 GQWWCGVYLALDVLFCT 108 (496) T ss_dssp HHHHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHH Confidence 36678887776554443 No 443 >4WW3_A BOG; Animals, Decapodiformes, Inositol 1, 4; HET: TWT, PC1, PLM, BOG, RET; 2.8A {Todarodes pacificus} Probab=30.81 E-value=7.2 Score=36.86 Aligned_cols=17 Identities=12% Similarity=0.038 Sum_probs=10.5 Template_Neff=12.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..++.. T Consensus 96 ~~~~c~~~~~~~~~~~~ 112 (350) T 4WW3_A 96 GFAACKVYGFIGGIFGF 112 (350) T ss_dssp HHHHHHHHHHHHHHHHH T ss_pred CchHHHHHHHHHHHHHH Confidence 35678777766554443 No 444 >6J20_A Substance-P receptor,Endolysin (E.C. 3.2.1.17); GPCR, Complex, Antagonist, signalling protein; HET: GBQ; 2.7A {Homo sapiens} Probab=30.61 E-value=7.3 Score=38.58 Aligned_cols=34 Identities=18% Similarity=0.236 Sum_probs=17.0 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..+......-.++ .=.-|...+. T Consensus 100 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~Ry~~i~ 134 (441) T 6J20_A 100 GLFYCKFHNFFPIAAVFASIWSMTAVAFDRYMAII 134 (441) T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhh Confidence 356788877766544433333322 2334444444 No 445 >5YWY_A Prostaglandin E2 receptor EP4 subtype; G-protein coupled receptor, lipid mediator; HET: 7UR; 3.2A {Homo sapiens} Probab=30.60 E-value=7.3 Score=36.50 Aligned_cols=34 Identities=12% Similarity=0.138 Sum_probs=16.9 Template_Neff=12.600 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+.+....-.++. -.-|...+. T Consensus 88 ~~~~c~~~~~~~~~~~~~s~~~~~~is~~R~~~i~ 122 (332) T 5YWY_A 88 GQPLCEYSTFILLFFSLSRLSIICAMSVERYLAIN 122 (332) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888776665544433333322 233444443 No 446 >4JKV_A Soluble cytochrome b562, Smoothened homolog; Human smoothened receptor, antitumor agent; HET: 1KS, PG4, PGE, OLA, PEG, OLC; 2.45A {Escherichia coli} Probab=30.35 E-value=7.5 Score=39.54 Aligned_cols=34 Identities=18% Similarity=0.213 Sum_probs=19.3 Template_Neff=9.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if 677 (908) ....|.+..++..+++...+.-+++-++-++..+ T Consensus 230 ~~~~C~~~~~l~~~~~las~~w~~~~a~~~~~~i 263 (475) T 4JKV_A 230 ETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSF 263 (475) T ss_dssp SCSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CchhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567887777766665555554444444444433 No 447 >4N4W_A Smoothened homolog; Human smoothened receptor, antitumor agent; HET: MAN, BMA, SNT, PG4, NAG, OLC; 2.8A {Homo sapiens, Shigella flexneri} Probab=30.35 E-value=7.5 Score=39.54 Aligned_cols=34 Identities=18% Similarity=0.213 Sum_probs=19.3 Template_Neff=9.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if 677 (908) ....|.+..++..+++...+.-+++-++-++..+ T Consensus 230 ~~~~C~~~~~l~~~~~las~~w~~~~a~~~~~~i 263 (475) T 4N4W_A 230 ETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSF 263 (475) T ss_dssp SCSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHGG T ss_pred CchhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567887777766665555554444444444433 No 448 >6FJ3_A Parathyroid hormone/parathyroid hormone-related peptide receptor; GPCR, cell signalling, 7TM, MEMBRANE; HET: FUC, OLA, NAG, MAN, YCM, PG4, HRG, BMA; 2.5A {Homo sapiens} Probab=30.23 E-value=7.5 Score=41.02 Aligned_cols=33 Identities=12% Similarity=0.126 Sum_probs=21.0 Template_Neff=10.000 Q NP_000836.2 646 IICSFRRVFLGLGMCFSYAALLTKTNRIHRIFE 678 (908) Q Consensus 646 ~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if~ 678 (908) ..|.+..+++...+...|.=+++-.+-+|+.+. T Consensus 214 ~~C~~~~~~~~y~~la~~~Wm~~e~~~l~~~i~ 246 (602) T 6FJ3_A 214 AGCRVAVTFFLYFLATNYYWIAVEGLYLHSLIF 246 (602) T ss_dssp -HHH-HHHH--HHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 678888888777777777777777766666544 No 449 >5ZBH_A Neuropeptide Y receptor type 1,T4; G Protein-Coupled Receptor Neuropeptide Y; HET: 9AF; 3.0A {Homo sapiens} Probab=29.80 E-value=7.7 Score=39.78 Aligned_cols=17 Identities=6% Similarity=0.305 Sum_probs=10.6 Template_Neff=11.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..+.+. T Consensus 118 ~~~~C~~~~~~~~~~~~ 134 (527) T 5ZBH_A 118 GEAMCKLNPFVQCVSIT 134 (527) T ss_pred hHHHHHHHHHHHHHHHH Confidence 35678887766554443 No 450 >6NIY_R Adenosine receptor A1,Soluble cytochrome b562,Adenosine; GPCR, transmembrane, receptor, calcitonin, MEMBRANE;{Homo sapiens} Probab=29.59 E-value=7.9 Score=39.32 Aligned_cols=27 Identities=19% Similarity=0.292 Sum_probs=15.1 Template_Neff=10.300 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTKTN 671 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K~~ 671 (908) ...|.+..++..+.....+.-+++-++ T Consensus 216 ~~~C~~~~~l~~~~~~~s~~w~~~ia~ 242 (474) T 6NIY_R 216 PVSCKILHFFHQYMMACNYFWMLCEGI 242 (474) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 567887776665554444444444443 No 451 >5XJM_A Type-2 angiotensin II receptor,Soluble cytochrome; class A GPCR, regulate human; 3.2A {Mus musculus} Probab=29.03 E-value=8.1 Score=37.87 Aligned_cols=34 Identities=21% Similarity=0.365 Sum_probs=17.6 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..++.....-.+++ -.-|...+. T Consensus 80 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 114 (422) T 5XJM_A 80 GPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVI 114 (422) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888877766554433333332 233444443 No 452 >6VMS_R Guanine nucleotide-binding protein G(i) subunit; Dopamine, Dopamine receptor, GPCR, G; HET: 08Y; 3.8A {Rattus norvegicus} Probab=28.87 E-value=8.2 Score=38.63 Aligned_cols=16 Identities=13% Similarity=0.044 Sum_probs=9.8 Template_Neff=11.300 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..+++. T Consensus 245 ~~~C~~~~~~~~~~~~ 260 (450) T 6VMS_R 245 RIHCDIFVTLDVMMCT 260 (450) T ss_dssp TTHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHH Confidence 5678777766554443 No 453 >6PS2_A Fusion protein of Beta-2 adrenergic; GPCR, COMPLEX-LCP method, SBDD, drug; HET: CLR, SO4, JTZ, OLB, OLA, OLC; 2.4A {Homo sapiens} Probab=28.33 E-value=8.5 Score=39.39 Aligned_cols=34 Identities=18% Similarity=0.134 Sum_probs=16.6 Template_Neff=10.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYA-ALLTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~-~l~~K~~ri~~if 677 (908) ....|.+..++..++.....- .++.=.-|.+.+. T Consensus 126 ~~~~C~~~~~l~~~~~~~s~~~~~~iai~Ry~ai~ 160 (506) T 6PS2_A 126 GNFWCEFWTSIDVLCVTASIWTLCVIAVDRYFAIT 160 (506) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred hhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 356788777765544433222 2233334544443 No 454 >6PB0_R Corticotropin-releasing factor receptor 1, Urocortin; Corticotropin-releasing factor 1 receptor, urocortins1; HET: CLR, PLM; 3.0A {Homo sapiens} Probab=28.25 E-value=8.6 Score=37.30 Aligned_cols=28 Identities=4% Similarity=-0.014 Sum_probs=17.0 Template_Neff=11.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTN 671 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ 671 (908) ....|.+..++...+....+..+++-.+ T Consensus 161 ~~~~C~~~~~~~~~~~~~s~~~l~~ia~ 188 (375) T 6PB0_R 161 NVGWCRLVTAAYNYFHVTNFFWMFGEGC 188 (375) T ss_dssp CCHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CchHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888777766655555555555443 No 455 >3PDS_A Fusion protein Beta-2 adrenergic receptor/Lysozyme; GPCR, signaling, beta adrenergic agonist; HET: ERC, CLR, SO4; 3.5A {Homo sapiens,Enterobacteria phage T4,Homo sapiens} Probab=28.08 E-value=8.7 Score=38.53 Aligned_cols=33 Identities=15% Similarity=0.119 Sum_probs=16.1 Template_Neff=11.400 Q NP_000836.2 645 TIICSFRRVFLGLGMCF-SYAALLTKTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l-~~~~l~~K~~ri~~if 677 (908) ...|.+..++..++... .+..++.=.-|.+.+. T Consensus 79 ~~~c~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 112 (458) T 3PDS_A 79 NFWCEFWTSIDVLCVTASIETLCVIAVDRYFAIT 112 (458) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHS T ss_pred cHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 56787777665544332 2223333334544443 No 456 >5UEN_B Adenosine receptor A1,Soluble cytochrome b562,Adenosine; GPCR, transmembrane, receptor, adenosine, MEMBRANE; HET: OLA, DU1; 3.2A {Homo sapiens} Probab=27.53 E-value=9 Score=37.51 Aligned_cols=16 Identities=6% Similarity=-0.155 Sum_probs=9.6 Template_Neff=12.200 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..+.+. T Consensus 78 ~~~C~~~~~~~~~~~~ 93 (416) T 5UEN_B 78 FHTCLMVACPVLILTQ 93 (416) T ss_dssp HHHHHHHHHHHHHHHH T ss_pred cchhHHHHHHHHHHHH Confidence 4578777766554443 No 457 >5ZBQ_A Neuropeptide Y Y1 receptor in; G Protein-Coupled Receptor, Receptor Inhibitor; HET: 9AO; 2.7A {Homo sapiens} Probab=27.31 E-value=9.1 Score=39.21 Aligned_cols=20 Identities=10% Similarity=0.287 Sum_probs=11.7 Template_Neff=11.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSY 663 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~ 663 (908) ....|.+..++..+++.... T Consensus 108 ~~~~C~~~~~~~~~~~~~s~ 127 (525) T 5ZBQ_A 108 GEAMCKLNPFVQCVSITVSI 127 (525) T ss_pred hHHHHHHHHHHHHHHHHHHH Confidence 35678877766655544333 No 458 >6RNK_A Succinate receptor 1, Nanobody6; SUCNR1, GPR91, GPCR, G-Protein coupled; HET: KAZ, OLC; 1.94A {Rattus norvegicus} Probab=27.26 E-value=9.1 Score=36.04 Aligned_cols=34 Identities=18% Similarity=0.179 Sum_probs=16.7 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++...++....-.++. -.-|...+. T Consensus 94 ~~~~c~~~~~~~~~~~~~s~~~~~~i~~~R~~~i~ 128 (342) T 6RNK_A 94 GDVLCISNRYVLHANLYTSILFLTFISIDRYLLMK 128 (342) T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 3567877776665544433333332 233444443 No 459 >5UEN_A Adenosine receptor A1,Soluble cytochrome b562,Adenosine; GPCR, transmembrane, receptor, adenosine, MEMBRANE; HET: DU1, OLA; 3.2A {Homo sapiens} Probab=27.12 E-value=9.2 Score=37.37 Aligned_cols=16 Identities=6% Similarity=-0.155 Sum_probs=9.6 Template_Neff=12.300 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..++.. T Consensus 78 ~~~C~~~~~~~~~~~~ 93 (416) T 5UEN_A 78 FHTCLMVACPVLILTQ 93 (416) T ss_dssp HHHHHHHHHHHHHHHH T ss_pred cchhHHHHHHHHHHHH Confidence 4578777766554443 No 460 >6PB1_P Corticotropin-releasing factor receptor 2, Urocortin; Corticotropin-releasing factor 2 receptor, urocortins1; HET: CLR, PLM; 2.8A {Homo sapiens} Probab=26.87 E-value=9.4 Score=37.30 Aligned_cols=33 Identities=6% Similarity=0.185 Sum_probs=20.5 Template_Neff=10.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTNRIHRI 676 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~i 676 (908) ....|.+..++...+....+..+++-.+-.|.. T Consensus 179 ~~~~C~~~~~~~~~~~~~s~~~l~~ia~~ry~~ 211 (387) T 6PB1_P 179 NEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTA 211 (387) T ss_dssp CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 457888887777666665555555555444433 No 461 >6OMM_R N-formyl peptide receptor 2, Peptide; Formyl peptide receptor 2/lipoxin A4; HET: PLM, CLR; 3.17A {Homo sapiens} Probab=26.55 E-value=9.6 Score=36.23 Aligned_cols=16 Identities=6% Similarity=0.468 Sum_probs=9.9 Template_Neff=12.500 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..+++. T Consensus 116 ~~~c~~~~~~~~~~~~ 131 (363) T 6OMM_R 116 WFLCKLIHIVVDINLF 131 (363) T ss_dssp HHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHH Confidence 5678777666554443 No 462 >5N2S_A Adenosine receptor A2a,Soluble cytochrome b562,Adenosine; G-PROTEIN-COUPLED RECEPTOR, INTEGRAL THERMOSTABILIZING MUTATIONS; HET: 8K8, SO4; 3.303A {Escherichia coli} Probab=26.30 E-value=9.8 Score=37.63 Aligned_cols=15 Identities=7% Similarity=-0.115 Sum_probs=8.7 Template_Neff=11.900 Q NP_000836.2 645 TIICSFRRVFLGLGM 659 (908) Q Consensus 645 ~~~C~~~~~~~~~gf 659 (908) ...|.+..++..+.+ T Consensus 184 ~~~c~~~~~~~~~~~ 198 (436) T 5N2S_A 184 FHTCLMVACPVLILA 198 (436) T ss_dssp HHHHHHHHHHHHHHH T ss_pred hHHHHHhHHHHHHHH Confidence 446777666655433 No 463 >5LWE_A C-C chemokine receptor type 9; Membrane protein; HET: CLR, 79K, MLI, OLA; 2.8A {Homo sapiens} Probab=25.09 E-value=11 Score=35.31 Aligned_cols=20 Identities=10% Similarity=0.283 Sum_probs=11.5 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSY 663 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~ 663 (908) ....|....++..+++.... T Consensus 93 ~~~~c~~~~~~~~~~~~~s~ 112 (331) T 5LWE_A 93 QTFMCKVVNSMYKMNFYSCV 112 (331) T ss_dssp -CHHHHHHHHHHHHHHHHHH T ss_pred chHHHHHHHHHHHHHHHHHH Confidence 46678877766555444333 No 464 >5ZTY_A G protein coupled receptor, T4; GPCR, cell signaling, ligand design; HET: OLC, SO4, PG4, OLA, 9JU, PEG, EPE; 2.8A {Homo sapiens} Probab=24.40 E-value=11 Score=38.32 Aligned_cols=20 Identities=15% Similarity=0.295 Sum_probs=9.0 Template_Neff=10.800 Q NP_000836.2 585 VVPVFVAILGIIATTFVIVT 604 (908) Q Consensus 585 ~~~~~~~~~~i~~~~~~~~~ 604 (908) ++..++.++|++.-+++++. T Consensus 37 ~~~~i~~~~gl~gN~lvl~~ 56 (500) T 5ZTY_A 37 VLCTLLGLLSALENVAVLYL 56 (500) T ss_pred HHHHHHHHHHHHHHHHHHHH Confidence 33444445555444444433 No 465 >2KSA_A Substance-P receptor, Substance P; Substance P, DMPC/CHAPS bicelle, Autodock; NMR {Homo sapiens} Probab=23.57 E-value=12 Score=35.48 Aligned_cols=16 Identities=19% Similarity=0.395 Sum_probs=9.5 Template_Neff=12.600 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++...++. T Consensus 102 ~~~c~~~~~~~~~~~~ 117 (364) T 2KSA_A 102 LFYCKFHNFFPIAAVF 117 (364) T ss_dssp HHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHH Confidence 5677776666554443 No 466 >5LWE_B C-C chemokine receptor type 9; Membrane protein; HET: 79K, OLA, MLI, CLR; 2.8A {Homo sapiens} Probab=23.45 E-value=12 Score=34.90 Aligned_cols=18 Identities=11% Similarity=0.333 Sum_probs=10.4 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..+++.. T Consensus 93 ~~~~c~~~~~~~~~~~~~ 110 (331) T 5LWE_B 93 QTFMCKVVNSMYKMNFYS 110 (331) T ss_dssp -CTTHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHHH Confidence 456787776665544443 No 467 >5DHG_B Nociceptin receptor-Cytochrome b562 Chimera; Nociceptin/orphanin FQ peptide receptor, NOP; HET: DGV, OLA, OLC; 3.0A {Escherichia coli} Probab=23.42 E-value=12 Score=36.65 Aligned_cols=34 Identities=18% Similarity=0.097 Sum_probs=17.4 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+++...+-.++.- ..|...+. T Consensus 193 ~~~~c~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 227 (424) T 5DHG_B 193 GNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAIC 227 (424) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 35678877776655544433333332 33444443 No 468 >5DHH_B GPCR-BRIL Chimera; Nociceptin/orphanin FQ peptide receptor, NOP; HET: OLA, OLC, DGW; 3.004A {Homo sapiens} Probab=23.42 E-value=12 Score=36.65 Aligned_cols=34 Identities=18% Similarity=0.097 Sum_probs=17.4 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+++...+-.++.- ..|...+. T Consensus 193 ~~~~c~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 227 (424) T 5DHH_B 193 GNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAIC 227 (424) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 35678877776655544433333332 33444443 No 469 >4DKL_A Mu-type opioid receptor, lysozyme chimera; G-protein coupled receptor, 7 transmembrane; HET: SO4, CLR, MPG, BF0, 1PE; 2.8A {Mus musculus, Enterobacteria phage T4} Probab=20.35 E-value=15 Score=36.47 Aligned_cols=17 Identities=18% Similarity=0.227 Sum_probs=10.1 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..+++. T Consensus 85 ~~~~C~~~~~~~~~~~~ 101 (464) T 4DKL_A 85 GNILCKIVISIDYYNMF 101 (464) T ss_dssp CSHHHHHHHHHHHHHHH T ss_pred cchHHHHHHHHHHHHHH Confidence 35678777766554433 No 470 >5NX2_A Glucagon-like peptide 1 receptor, truncated; 7TM, GPCR, signalling protein, membrane; HET: SOG, 9DQ, 9DZ, 9DT, 9DW, 9DK, NAG; 3.7A {Homo sapiens} Probab=20.13 E-value=16 Score=36.14 Aligned_cols=33 Identities=15% Similarity=0.316 Sum_probs=19.8 Template_Neff=10.600 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTKTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if 677 (908) +..|.+..++........+.-+++-.+-+++.. T Consensus 204 ~~~C~~~~~~~~~~~las~~w~~~~~~~~~~~i 236 (422) T 5NX2_A 204 SLSCRLVFLFMQYCVAANYYWLLVEGVYLYTLL 236 (422) T ss_dssp SHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC T ss_pred cHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 478888777766665555555555554444443 No 471 >6LN2_A Glucagon-like peptide 1 receptor,Rubredoxin,Glucagon-like peptide; Full length Human GLP1 receptor; HET: 97Y, NAG; 3.2A {Homo sapiens} Probab=20.07 E-value=16 Score=36.87 Aligned_cols=35 Identities=14% Similarity=0.264 Sum_probs=21.7 Template_Neff=8.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFE 678 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if~ 678 (908) ....|.+..++....+...+.-+++-.+-+++.+. T Consensus 199 ~~~~C~~~~~l~~y~~las~~W~~~~a~~l~~~i~ 233 (469) T 6LN2_A 199 DSLACRLVFLLCQYCVAANYYWLLVEGVYLYTLLA 233 (469) T ss_dssp HHTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35778888777766666666666555555444443