Mercurial > repos > iuc > hyphy_absrel

annotate hyphy_absrel.xml @ 31:26de3a7b1cb9 draft

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"planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hyphy/ commit 9ef881c2d3d5f240cbff33667b55f72cb82d9896"
author iuc
date Tue, 05 Oct 2021 05:11:08 +0000
parents 5f2ca10db92a
children 3f59ebfbfe3d
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1 <?xml version="1.0"?>
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2 <tool id="hyphy_absrel" name="HyPhy-aBSREL" version="@VERSION@+galaxy1" profile="19.09">
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3 <description>adaptive Branch Site Random Effects Likelihood</description>
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4 <expand macro="bio_tools"/>
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5 <macros>
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6 <import>macros.xml</import>
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7 </macros>
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8 <expand macro="requirements"/>
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9 <command detect_errors="exit_code"><![CDATA[
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10 @SYMLINK_FILES@
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11 ln -s '$absrel_output' ${input_file}.aBSREL.json &&
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12 @HYPHYMPI@ absrel
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13 --alignment ./$input_file
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14 @INPUT_TREE@
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15 --code '$gencodeid'
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16 @branch_options@
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17 --output '$absrel_output'
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18 --multiple-hits $multiple_hits
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19 @ERRORS@
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20 ]]></command>
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21 <inputs>
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22 <expand macro="inputs"/>
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23 <param name="log" type="boolean" truevalue="" falsevalue="" label="Output aBSREL log to history"/>
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24 <expand macro="gencode"/>
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25 <param name="multiple_hits" type="select" argument="--multiple-hits" label="Include support for multiple nucleotide substitutions">
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26 <option value="None">Use standard models which permit only single nucleotide changes to occur instantly</option>
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27 <option value="Double">Include branch-specific rates for double nucleotide substitutions</option>
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28 <option value="Double+Triple">Include branch-specific rates for double and triple nucleotide substitutions</option>
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29 </param>
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30 <expand macro="branches"/>
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31 </inputs>
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32 <outputs>
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33 <data name="absrel_output" format="hyphy_results.json" />
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34 </outputs>
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35 <tests>
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36 <test>
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37 <param name="input_file" ftype="fasta" value="absrel-in1.fa"/>
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38 <param name="input_nhx" ftype="nhx" value="absrel-in1.nhx"/>
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39 <param name="multiple_hits" value="None" />
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40 <output name="absrel_output" file="absrel-out1.json" compare="sim_size"/>
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41 </test>
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42 <test>
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43 <param name="input_file" ftype="fasta" value="absrel-in1.fa"/>
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44 <param name="input_nhx" ftype="nhx" value="absrel-in1.nhx"/>
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45 <param name="multiple_hits" value="Double" />
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46 <output name="absrel_output" file="absrel-out1.json" compare="sim_size"/>
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47 </test>
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48 </tests>
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49 <help><![CDATA[
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50
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51 aBSREL : Adaptive Branch-Site Random Effects Likelihood
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52 =======================================================
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54 What question does this method answer?
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55 --------------------------------------
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57 Is some proportion of sites is subject to positive selection along specific branches or lineages of a phylogeny?
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59 Recommended Applications
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60 ------------------------
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62 1. Exploratory testing for evidence of lineage-specific positive diversifying selection in small to medium sized alignments (up to 100 sequences).
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63 2. Targeted testing of branches selected a priori for positive diversifying selection, including alignments with prohibitive runtimes under older branch-site models (up to 1,000 sequences)
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64
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65 Brief description
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66 -----------------
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68 aBSREL (Adaptive branch-site random effects likelihood) uses an adaptive
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69 random effects branch-site model framework to test whether each branch
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70 has evolved under positive selection, using a procedure which infers an
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71 optimal number of rate categories per branch.
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74 Input
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75 -----
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77 1. A *FASTA* sequence alignment.
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78 2. A phylogenetic tree in the *Newick* format
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79
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80 Note: the names of sequences in the alignment must match the names of the sequences in the tree.
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83 Output
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84 ------
2
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85
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86 A JSON file with analysis results (http://hyphy.org/resources/json-fields.pdf).
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87
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88 For each tested branch the analysis will infer the appropriate number of selective regimes,
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89 and whether or not there is statistical evidence of positive selection on that branch.
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90
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91 A custom visualization module for viewing these results is available (see http://vision.hyphy.org/aBSREL for an example)
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92
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93 Further reading
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94 ---------------
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95
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96 http://hyphy.org/methods/selection-methods/#absrel
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97
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98
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99 Tool options
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100 ------------
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101 ::
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102
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103
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104 --code Which genetic code to use
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105
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106 --branches Which branches should be tested for selection?
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107 All [default] : test all branches
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108
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109 Internal : test only internal branches (suitable for
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110 intra-host pathogen evolution for example, where terminal branches
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111 may contain polymorphism data)
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112
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113 Leaves: test only terminal (leaf) branches
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114
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115 Unlabeled: if the Newick string is labeled using the {} notation,
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116 test only branches without explicit labels
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117 (see http://hyphy.org/tutorials/phylotree/)
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118
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119
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120
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121 ]]></help>
0
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122 <expand macro="citations">
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123 <citation type="doi">10.1093/molbev/msv022</citation>
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124 </expand>
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125 </tool>