Mercurial > repos > iuc > hyphy_relax

annotate hyphy_relax.xml @ 34:5eb9d7217640 draft default tip

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planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hyphy/ commit e7a89841d59689e87db592e112f9c8fb5331d954
author iuc
date Thu, 02 Mar 2023 15:10:19 +0000
parents 7207313de5a8
children
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5eb9d7217640 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hyphy/ commit e7a89841d59689e87db592e112f9c8fb5331d954
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1 <tool id="hyphy_relax" name="HyPhy-RELAX" version="@TOOL_VERSION@+galaxy@VERSION_SUFFIX@" profile="@PROFILE@">
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2 <description>Detect relaxed selection in a codon-based
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3 phylogenetic framework</description>
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4 <macros>
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5 <import>macros.xml</import>
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6 </macros>
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7 <expand macro="bio_tools"/>
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8 <expand macro="requirements"/>
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9 <command detect_errors="exit_code"><![CDATA[
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10 @SYMLINK_FILES@
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11 export OMP_NUM_THREADS="\${GALAXY_SLOTS:-1}" &&
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12 hyphy relax
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13 --alignment ./$input_file
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14 @INPUT_TREE@
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15 --models '$models'
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16 --code '$gencodeid'
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17 --test '$test'
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18 #if $reference:
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19 --reference '$reference'
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20 #end if
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21 @advanced_options@
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22 --output '$relax_output'
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23 @ERRORS@
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24 ]]></command>
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25 <inputs>
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26 <expand macro="inputs"/>
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27 <expand macro="gencode"/>
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28 <param argument="--models" type="select" label="Analysis Type" >
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29 <option value="All">All</option>
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30 <option value="Minimal">Minimal</option>
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31 </param>
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32 <param argument="--test" type="text" value="Unlabeled branches" optional="false" label="Branches to use as the test set">
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33 <sanitizer invalid_char="">
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34 <valid initial="default" />
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35 </sanitizer>
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36 </param>
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37 <param argument="--reference" type="text" optional="true" label="Branches to use as the reference set">
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38 <sanitizer invalid_char="">
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39 <valid initial="default" />
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40 </sanitizer>
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41 </param>
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42 <expand macro="srv" />
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43 </inputs>
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44 <outputs>
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45 <data name="relax_output" format="hyphy_results.json"/>
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46 <expand macro="alternative_model_output" />
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47 </outputs>
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48 <tests>
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49 <test>
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50 <param name="input_file" ftype="fasta" value="relax-in1.fa"/>
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51 <param name="input_nhx" ftype="nhx" value="relax-in1.nhx"/>
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52 <param name="test" value="TEST" />
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53 <output name="relax_output" file="relax-out1.json" compare="sim_size"/>
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54 </test>
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55 <test>
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56 <param name="input_file" ftype="nex" value="relax-in2.nex"/>
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57 <param name="test" value="PR" />
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58 <conditional name="advanced">
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59 <param name="srv_options" value="specify" />
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60 <param name="save_alternative_model" value="true" />
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61 <param name="srv" value="false" />
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62 </conditional>
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63 <output name="relax_output" file="relax-out2-1.json" compare="sim_size"/>
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64 </test>
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65 </tests>
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66 <help><![CDATA[
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67 RELAX: a test for selection differences
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68 =======================================
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69
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70 What question does this method answer?
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71 --------------------------------------
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72
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73 Is there evidence the strength of selection has been relaxed (or conversely intensified) on a specified group of lineages (TEST)
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74 relative to a set of reference lineages (RELAX)? Importantly, RELAX is not designed to detect diversifying selection specifically.
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75 We note that the RELAX framework can perform both this specific hypothesis test as well as fit a suite of descriptive models which address,
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76 or example, overall rate differences between test and reference branches or lineage-specific inferences of selection relaxation.
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77
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78 Recommended Applications
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79 ------------------------
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81 1. Testing for a systematic shift (relaxation / intensification) in the distribution of selection pressure associated with major biological transitions such as hosting switching in viruses, lifestyle evolution in bacteria (i.e. transition from free-living to endosymbiotic lifestyle
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82 2. Comparing selective regimes between two subsets of branches in the tree, e.g. to investigate selective differences due an environmental/phenotypic changes.
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85 Brief description
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86 -----------------
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87
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88 RELAX (a random effects test of selection relaxation) uses a random
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89 effects branch-site model framework to test whether a set of 'Test'
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90 branches evolves under relaxed selection relative to a set of
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91 'Reference' branches (R), as measured by the relaxation parameter (K).
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92
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93 Input
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94 -----
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95
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96 1. A *FASTA* sequence alignment.
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97 2. A phylogenetic tree in the *Newick* format that is further partitioned into one or two groups (_TEST_ or _TEST_ and _REFERENCE_). See http://hyphy.org/tutorials/phylotree/
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98
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99 Note: the names of sequences in the alignment must match the names of the sequences in the tree.
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100
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101
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102 Output
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103 ------
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104
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105 A JSON file with analysis results (http://hyphy.org/resources/json-fields.pdf).
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106
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107 A custom visualization module for viewing these results is available (see http://vision.hyphy.org/RELAX for an example)
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108
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109 Further reading
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110 ---------------
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111
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112 http://hyphy.org/methods/selection-methods/#RELAX
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113
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114
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115 Tool options
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116 ------------
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117 ::
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118
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119
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120 --code Which genetic code to use
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121
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122 --model Which type of test to run
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123 All : fit 4 different models [default]
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124 Minimal: only perform a 2-model test of relaxation/intensification [faster]
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125
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126
0
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127 ]]></help>
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128 <expand macro="citations">
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129 <citation type="doi">10.1093/molbev/msu400</citation>
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130 </expand>
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131 </tool>