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+++ b/tool_dependencies.xml	Thu Jan 22 07:50:39 2015 -0500
@@ -0,0 +1,47 @@
+<?xml version="1.0"?>
+<tool_dependency>
+    <package name="snpEff" version="4.0">
+        <install version="1.0">
+            <actions>
+                <action type="download_by_url">https://downloads.sourceforge.net/project/snpeff/snpEff_v4_0_core.zip</action>
+                <action type="move_directory_files">
+                    <source_directory>.</source_directory>
+                    <destination_directory>$INSTALL_DIR</destination_directory>
+                </action>
+                <action type="shell_command">sed -i.orig 's;http://downloads.sourceforge.net/project/snpeff/databases;https://snpeff-data.galaxyproject.org/databases;g' $INSTALL_DIR/snpEff.config</action>
+                <action type="set_environment">
+                    <environment_variable name="SNPEFF_JAR_PATH" action="set_to">$INSTALL_DIR</environment_variable>
+                </action>
+                <action type="set_environment">
+                    <environment_variable name="PATH" action="prepend_to">$INSTALL_DIR/scripts</environment_variable>
+                </action>
+            </actions>
+        </install>
+        <readme>
+SnpEff and SnpSift
+
+SnpEff ( http://snpeff.sourceforge.net/ ) is a variant annotation and effect prediction tool by Pablo Cingolani.
+It annotates and predicts the effects of variants on genes (such as amino acid changes).
+
+This repository contains a tool_dependencies.xml file that downloads and installs SnpEff and SnpSift (SnpEff.jar and SnpSift.jar)
+
+The install creates an environment variable: SNPEFF_JAR_PATH that contains the path to the jar files. Tools using this can generate a command line:
+java -Xmx6G -jar \$SNPEFF_JAR_PATH/snpEff.jar eff -c \$SNPEFF_JAR_PATH/snpEff.config ...
+
+The snpEff.config file is also installed, which specifies the default location for installed SnpEff genome databases:
+data_dir = ~/snpEff/data/
+
+The location of a genome database can be set via the commandline option -dataDir. Tools using this can generate a command line:
+java -Xmx6G -jar \$SNPEFF_JAR_PATH/snpEff.jar eff -c \$SNPEFF_JAR_PATH/snpEff.config -dataDir path_to_data_directory snpeff_database_name input.vcf
+
+Another way to change the location of data_dir would be to create a symbolic link in the galaxy HOME directory:
+ln -s genome_data_path/snpEff ~/snpEff
+
+SnpEff citation:
+"A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3.", Cingolani P, Platts A, Wang le L, Coon M, Nguyen T, Wang L, Land SJ, Lu X, Ruden DM. Fly 6(2):80-92, 2012
+
+SnpSift citation:
+"Using Drosophila melanogaster as a model for genotoxic chemical mutational studies with a new program, SnpSift", Cingolani, P., et. al., Frontiers in Genetics, 3:35, 2012.
+        </readme>
+    </package>
+</tool_dependency>