>     1== M63632   1 Lampetra japonica rhodopsin <>[BBRC174,1125-1132'91]
MN-------------------GTE------GDNFYVPF----------------SNKTGL
-----------ARSPYEYPQY-----YLAEPWK--------------------Y------
------------------SALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNL
AMANLFMVLFG-FTVTMYTSMN-GYFV--FGPTMCSIEGFFATLGGEVALWSLVVLAIER
YIVICKPMGN-FRFGNTHAIMGVAFTWIMALAC-AAPPLVG-W-----SRYIPEGMQCSC
GPDYYTLNPNFNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTV----KE-----------
------------------------------------------------------------
------------------------------------------------------------
---AAAAQQ------------------------------------ESASTQKAEKEVTRM
VVLMVIGFLVCWVPYASVAFYIFT-HQGS--DFGATFMTLPAFFAKSSALYNPVIYILMN
KQFRNCMITTLC----C---GKNPLGD-DE--SGASTSKTEV------------------
------------------------------------------------------------
---SSVS-------TSPVSP-A----------
>     2== U22180   1 rat opsin <rod>[J.Mol.Neurosci.5(3),207-209'94]
MN-------------------GTE------GPNFYVPF----------------SNITGV
-----------VRSPFEQPQY-----YLAEPWQ--------------------F------
------------------SMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNL
AVADLFMVFGG-FTTTLYTSLH-GYFV--FGPTGCNLEGFFATLGGEIGLWSLVVLAIER
YVVVCKPMSN-FRFGENHAIMGVAFTWVMALAC-AAPPLVG-W-----SRYIPEGMQCSC
GIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTV----KE-----------
------------------------------------------------------------
------------------------------------------------------------
---AAAQQQ------------------------------------ESATTQKAEKEVTRM
VIIMVIFFLICWLPYASVAMYIFT-HQGS--NFGPIFMTLPAFFAKTASIYNPIIYIMMN
KQFRNCMLTSLC----C---GKNPLGD-DE--ASATASKTE-------------------
------------------------------------------------------------
--------------TSQVAP-A----------
>     3== M92038   1 chicken green sensitive cone opsin <retina>[PNAS89,5932-5936'9
MN-------------------GTE------GINFYVPM----------------SNKTGV
-----------VRSPFEYPQY-----YLAEPWK--------------------Y------
------------------RLVCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNL
AVADLFMACFG-FTVTFYTAWN-GYFV--FGPVGCAVEGFFATLGGQVALWSLVVLAIER
YIVVCKPMGN-FRFSATHAMMGIAFTWVMAFSC-AAPPLFG-W-----SRYMPEGMQCSC
GPDYYTHNPDYHNESYVLYMFVIHFIIPVVVIFFSYGRLICKV----RE-----------
------------------------------------------------------------
------------------------------------------------------------
---AAAQQQ------------------------------------ESATTQKAEKEVTRM
VILMVLGFMLAWTPYAVVAFWIFT-NKGA--DFTATLMAVPAFFSKSSSLYNPIIYVLMN
KQFRNCMITTIC----C---GKNPFGD-EDVSSTVSQSKTEV------------------
------------------------------------------------------------
---SSVS-------SSQVSP-A----------
>     4=p A45229 opsin, green-sensitive (clone GFgr-1) - goldfish
MN-------------------GTE------GKNFYVPM----------------SNRTGL
-----------VRSPFEYPQY-----YLAEPWQ--------------------F------
------------------KILALYLFFLMSMGLPINGLTLVVTAQHKKLRQPLNFILVNL
AVAGTIMVCFG-FTVTFYTAIN-GYFV--LGPTGCAVEGFMATLGGEVALWSLVVLAIER
YIVVCKPMGS-FKFSSSHAFAGIAFTWVMALAC-AAPPLFG-W-----SRYIPEGMQCSC
GPDYYTLNPDYNNESYVIYMFVCHFILPVAVIFFTYGRLVCTV----KA-----------
------------------------------------------------------------
------------------------------------------------------------
---AAAQQQ------------------------------------DSASTQKAEREVTKM
VILMVFGFLIAWTPYATVAAWIFF-NKGA--DFSAKFMAIPAFFSKSSALYNPVIYVLLN
KQFRNCMLTTIF----C---GKNPLGD-DE-SSTVSTSKTEV------------------
------------------------------------------------------------
---SS------------VSP-A----------
>     5=p B45229 opsin, green-sensitive (clone GFgr-2) - goldfish
MN-------------------GTE------GNNFYVPL----------------SNRTGL
-----------VRSPFEYPQY-----YLAEPWQ--------------------F------
------------------KLLAVYMFFLICLGLPINGLTLICTAQHKKLRQPLNFILVNL
AVAGAIMVCFG-FTVTFYTAIN-GYFA--LGPTGCAVEGFMATLGGEVALWSLVVLAIER
YIVVCKPMGS-FKFSSTHASAGIAFTWVMAMAC-AAPPLVG-W-----SRYIPEGIQCSC
GPDYYTLNPEYNNESYVLYMFICHFILPVTIIFFTYGRLVCTV----KA-----------
------------------------------------------------------------
------------------------------------------------------------
---AAAQQQ------------------------------------DSASTQKAEREVTKM
VILMVLGFLVAWTPYATVAAWIFF-NKGA--AFSAQFMAIPAFFSKTSALYNPVIYVLLN
KQFRSCMLTTLF----C---GKNPLGD-EE-SSTVSTSKTEV------------------
------------------------------------------------------------
---SS------------VSP-A----------
>     6== L11864   1 Carassius auratus blue cone opsin <retina>[Biochemistry32,208-
MK-------------------QVPE----FHEDFYIPIPL------------DINNLSAY
-------------SPFLVPQD-----HLGNQGI--------------------F------
------------------MAMSVFMFFIFIGGASINILTILCTIQFKKLRSHLNYILVNL
SIANLFVAIFG-SPLSFYSFFN-RYFI--FGATACKIEGFLATLGGMVGLWSLAVVAFER
WLVICKPLGN-FTFKTPHAIAGCILPWISALAA-SLPPLFG-W-----SRYIPEGLQCSC
GPDWYTTNNKYNNESYVMFLFCFCFAVPFGTIVFCYGQLLITL----KL-----------
------------------------------------------------------------
------------------------------------------------------------
---AAKAQA------------------------------------DSASTQKAEREVTKM
VVVMVLGFLVCWAPYASFSLWIVS-HRGE--EFDLRMATIPSCLSKASTVYNPVIYVLMN
KQFRSCMM-KMV----C---GKN-IEE-DE--ASTSSQVTQV------------------
------------------------------------------------------------
---SS------------VAPEK----------
>     7== M13299   1 human BCP <>[Science232(4747),193-202'86]
MR-------------------KMS------EEEFYL-----------------FKNISSV
-------------GPWDGPQY-----HIAPVWA--------------------F------
------------------YLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNV
SFGGFLLCIFS-VFPVFVASCN-GYFV--FGRHVCALEGFLGTVAGLVTGWSLAFLAFER
YIVICKPFGN-FRFSSKHALTVVLATWTIGIGV-SIPPFFG-W-----SRFIPEGLQCSC
GPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRAL----KA-----------
------------------------------------------------------------
------------------------------------------------------------
---VAAQQQ------------------------------------ESATTQKAEREVSRM
VVVMVGSFCVCYVPYAAFAMYMVN-NRNH--GLDLRLVTIPSFFSKSACIYNPIIYCFMN
KQFQACIM-KMV----C---GKA-MTD-ES--DTCSSQKTEV------------------
------------------------------------------------------------
---STVS-------STQVGP-N----------
>     8=opsin, greensensitive  human (fragment) S07060
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---DLAETVIA-STISIVNQVS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWER
WLVVCKPFGN-VRFDAKLAIVGIAFSWIWAAVW-TAPPIFG-W-----SRYWPHGLKTSC
GPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAI----RA-----------
------------------------------------------------------------
------------------------------------------------------------
---VAKQQK------------------------------------ESESTQKAEKEVTRM
VVVMVLAFC---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------
>     9== K03494   1 human GCP <>[Science232(4747),193-202'86]
MAQQWSLQRLAGRHPQDSYEDSTQ------SSIFTYTN----------------SNST--
------------RGPFEGPNY-----HIAPRWV--------------------Y------
------------------HLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNL
AVADLAETVIA-STISVVNQVY-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWER
WMVVCKPFGN-VRFDAKLAIVGIAFSWIWAAVW-TAPPIFG-W-----SRYWPHGLKTSC
GPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAI----RA-----------
------------------------------------------------------------
------------------------------------------------------------
---VAKQQK------------------------------------ESESTQKAEKEVTRM
VVVMVLAFCFCWGPYAFFACFAAA-NPGY--PFHPLMAALPAFFAKSATIYNPVIYVFMN
RQFRNCILQLF---------GKK-VDD-GS--ELSSASKTEV------------------
------------------------------------------------------------
---SSV---------SSVSP-A----------
>    10== Z68193   1 human Red Opsin <>[]
MAQQWSLQRLAGRHPQDSYEDSTQ------SSIFTYTN----------------SNST--
------------RGPFEGPNY-----HIAPRWV--------------------Y------
------------------HLTSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNL
AVADLAETVIA-STISIVNQVS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWER
WLVVCKPFGN-VRFDAKLAIVGIAFSWIWSAVW-TAPPIFG-W-----SRYWPHGLKTSC
GPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAI----RA-----------
------------------------------------------------------------
------------------------------------------------------------
---VAKQQK------------------------------------ESESTQKAEKEVTRM
VVVMIFAYCVCWGPYTFFACFAAA-NPGY--AFHPLMAALPAYFAKSATIYNPVIYVFMN
RQFRNCILQLF---------GKK-VDD-GS--ELSSASKTEV------------------
------------------------------------------------------------
---SSV---------SSVSP-A----------
>    11== M92036   1 Gecko gecko P521 <retina>[PNAS89,6841-6845'92]
MTEAWNVAVFAARRSRDD-DDTTR------GSVFTYTN----------------TNNT--
------------RGPFEGPNY-----HIAPRWV--------------------Y------
------------------NLVSFFMIIVVIASCFTNGLVLVATAKFKKLRHPLNWILVNL
AFVDLVETLVA-STISVFNQIF-GYFI--LGHPLCVIEGYVVSSCGITGLWSLAIISWER
WFVVCKPFGN-IKFDSKLAIIGIVFSWVWAWGW-SAPPIFG-W-----SRYWPHGLKTSC
GPDVFSGSVELGCQSFMLTLMITCCFLPLFIIIVCYLQVWMAI----RA-----------
------------------------------------------------------------
------------------------------------------------------------
---VAAQQK------------------------------------ESESTQKAEREVSRM
VVVMIVAFCICWGPYASFVSFAAA-NPGY--AFHPLAAALPAYFAKSATIYNPVIYVFMN
RQFRNCIMQLF---------GKK-VDD-GS--EASTTSRTEV------------------
------------------------------------------------------------
---SSVS-------NSSVAP-A----------
>    12== M62903   1 chicken visual pigment <>[BBRC173,1212-1217'90]
MA-AWEAAFAARRRHEE--EDTTR------DSVFTYTN----------------SNNT--
------------RGPFEGPNY-----HIAPRWV--------------------Y------
------------------NLTSVWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNL
AVADLGETVIA-STISVINQIS-GYFI--LGHPMCVVEGYTVSACGITALWSLAIISWER
WFVVCKPFGN-IKFDGKLAVAGILFSWLWSCAW-TAPPIFG-W-----SRYWPHGLKTSC
GPDVFSGSSDPGVQSYMVVLMVTCCFFPLAIIILCYLQVWLAI----RA-----------
------------------------------------------------------------
------------------------------------------------------------
---VAAQQK------------------------------------ESESTQKAEKEVSRM
VVVMIVAYCFCWGPYTFFACFAAA-NPGY--AFHPLAAALPAYFAKSATIYNPIIYVFMN
RQFRNCILQLF---------GKK-VDD-GS--EVST-SRTEV------------------
------------------------------------------------------------
---SSVS-------NSSVSP-A----------
>    13== S75720   1 chicken P-opsin <>[Science267(5203),1502-1506'95]
MS-----------------SNSSQ------AP----------------------PNGT--
------------PGPFDGPQW----PYQAPQST--------------------Y------
------------------VGVAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNL
AVADLLVTLCG-SSVSLSNNIN-GFFV--FGRRMCELEGFMVSLTGIVGLWSLAILALER
YVVVCKPLGD-FQFQRRHAVSGCAFTWGWALLW-SAPPLLG-W-----SSYVPEGLRTSC
GPNWYTGGS--NNNSYILSLFVTCFVLPLSLILFSYTNLLLTL----RA-----------
------------------------------------------------------------
------------------------------------------------------------
---AAAQQK------------------------------------EADTTQRAEREVTRM
VIVMVMAFLLCWLPYSTFALVVAT-HKGI--IIQPVLASLPSYFSKTATVYNPIIYVFMN
KQFQSCLLEMLC----CGYQPQR-TGK-AS--PGTPGPHADV------------------
------------------------------------------------------------
---TAAG------LRNKVMP-AH-------PV
>    14== M17718   1 D.melanogaster Rh3 <>[J.Neurosci.7,1550-1557'87]
MESGNV---------------SSSLFGNVST-ALRPEARLSA---ETRLLGW--------
------------NVPPEELR------HIPEHWL-----------TYPEPPESMN------
------------------YLLGTLYIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILVINL
AFCDFMMMVK--TPIFIYNSFH-QGYA--LGHLGCQIFGIIGSYTGIAAGATNAFIAYDR
FNVITRPMEG--KMTHGKAIAMIIFIYMYATPW-VVACYTETW-----GRFVPEGYLTSC
TFDYLT--DNFDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKA-----------
------------------------------------------------------------
------------------------------------------------------------
---LRDQAKK----------MNVESL----------------RSNVDKNKETAEIRIAKA
AITICFLFFCSWTPYGVMSLIGAF-GDKT--LLTPGATMIPACACKMVACIDPFVYAISH
PRYRMELQKRCP----WLALNEKAPE--SS-AVASTSTTQEP------------------
------------------------------------------------------------
---------------QQTTA-A----------
>    15== X65879   1 Drosophila pseudoobscura Dpse\Rh3 <>[Genetics132(1),193-204'92
MEYHNV---------------SSVL-GNVSS-VLRPDARLSA---ESRLLGW--------
------------NVPPDELR------HIPEHWL-----------IYPEPPESMN------
------------------YLLGTLYIFFTVISMIGNGLVMWVFSAAKSLRTPSNILVINL
AFCDFMMMIK--TPIFIYNSFH-QGYA--LGHLGCQIFGVIGSYTGIAAGATNAFIAYDR
YNVITRPMEG--KMTHGKAIAMIIFIYLYATPW-VVACYTESW-----GRFVPEGYLTSC
TFDYLT--DNFDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKA-----------
------------------------------------------------------------
------------------------------------------------------------
---LRDQAKK----------MNVDSL----------------RSNVDKSKEAAEIRIAKA
AITICFLFFASWTPYGVMSLIGAF-GDKT--LLTPGATMIPACTCKMVACIDPFVYAISH
PRYRMELQKRCP----WLAISEKAPE--SR-AAISTSTTQEQ------------------
------------------------------------------------------------
---------------QQTTA-A----------
>    16== M17730   1 D.melanogaster Rh4 opsin <>[J.Neurosci.7,1558-1566'87]
ME---------------------PL-CNASEPPLRPEAR-SSGNGDLQFLGW--------
------------NVPPDQIQ------YIPEHWL-----------TQLEPPASMH------
------------------YMLGVFYIFLFCASTVGNGMVIWIFSTSKSLRTPSNMFVLNL
AVFDLIMCLK--APIF--NSFH-RGFAIYLGNTWCQIFASIGSYSGIGAGMTNAAIGYDR
YNVITKPMNR--NMTFTKAVIMNIIIWLYCTPW-VVLPLTQFW-----DRFVPEGYLTSC
SFDYLS--DNFDTRLFVGTIFFFSFVCPTLMILYYYSQIVGHVFSHEKA-----------
------------------------------------------------------------
------------------------------------------------------------
---LREQAKK----------MNVESL----------------RSNVDKSKETAEIRIAKA
AITICFLFFVSWTPYGVMSLIGAF-GDKS--LLTQGATMIPACTCKLVACIDPFVYAISH
PRYRLELQKRCP----WLGVNEKSGE--IS-SAQST-TTQEQ------------------
------------------------------------------------------------
---------------QQTTA-A----------
>    17== X65880   1 Drosophila pseudoobscura Dpse\Rh4 <>[Genetics132(1),193-204'92
MD---------------------AL-CNASEPPLRPEARMSSGSDELQFLGW--------
------------NVPPDQIQ------YIPEHWL-----------TQLEPPASMH------
------------------YMLGVFYIFLFFASTLGNGMVIWIFSTSKSLRTPSNMFVLNL
AVFDLIMCLK--APIFIYNSFH-RGFA--LGNTWCQIFASIGSYSGIGAGMTNAAIGYDR
YNVITKPMNR--NMTFTKAVIMNIIIWLYCTPW-VVLPLTQFW-----DRFVPEGYLTSC
SFDYLS--DNFDTRLFVGTIFLFSFVVPTLMILYYYSQIVGHVFNHEKA-----------
------------------------------------------------------------
------------------------------------------------------------
---LREQAKK----------MNVESL----------------RSNVDKSKETAEIRIAKA
AITICFLFFVSWTPYGVMSLIGAF-GDKS--LLTPGATMIPACTCKLVACIEPFVYAISH
PRYRMELQKRCP----WLGVNEKSGE--AS-SAQST-TTQEQ------------------
------------------------------------------------------------
--------------TQQTSA-A----------
>    18== D50584   1 Hemigrapsus sanguineus opsin BcRh2 <compound eye>[J.Exp.Biol.1
MT-------------------------NATGPQMAYYGAASMD------FGYP-EGVSIV
-----------DFVRPEIKP------YVHQHWY-----------NYPPVNPMWH------
------------------YLLGVIYLFLGTVSIFGNGLVIYLFNKSAALRTPANILVVNL
ALSDLIMLTTN-VPFFTYNCFSGGVWM--FSPQYCEIYACLGAITGVCSIWLLCMISFDR
YNIICNGFNG-PKLTTGKAVVFALISWVIAIGC-ALPPFFG-W-----GNYILEGILDSC
SYDYLT--QDFNTFSYNIFIFVFDYFLPAAIIVFSYVFIVKAIFAHEAA-----------
------------------------------------------------------------
------------------------------------------------------------
---MRAQAKK----------MNVSTL----------------RS-NEADAQRAEIRIAKT
ALVNVSLWFICWTPYALISLKGVM-GDTS--GITPLVSTLPALLAKSCSCYNPFVYAISH
PKYRLAITQHLP----WFCVHETETKS-ND-DSQSNSTVAQ-------------------
------------------------------------------------------------
------------------DK-A----------
>    19== D50583   1 Hemigrapsus sanguineus opsin BcRh1 <compound eye>[J.Exp.Biol.1
MA-------------------------NVTGPQMAFYGSGAAT------FGYP-EGMTVA
-----------DFVPDRVKH------MVLDHWY-----------NYPPVNPMWH------
------------------YLLGVVYLFLGVISIAGNGLVIYLYMKSQALKTPANMLIVNL
ALSDLIMLTTN-FPPFCYNCFSGGRWM--FSGTYCEIYAALGAITGVCSIWTLCMISFDR
YNIICNGFNG-PKLTQGKATFMCGLAWVISVGW-SLPPFFG-W-----GSYTLEGILDSC
SYDYFT--RDMNTITYNICIFIFDFFLPASVIVFSYVFIVKAIFAHEAA-----------
------------------------------------------------------------
------------------------------------------------------------
---MRAQAKK----------MNVTNL----------------RS-NEAETQRAEIRIAKT
ALVNVSLWFICWTPYAAITIQGLL-GNAE--GITPLLTTLPALLAKSCSCYNPFVYAISH
PKFRLAITQHLP----WFCVHEKDPND-VE-ENQSSNTQTQ-------------------
------------------------------------------------------------
------------------EK-S----------
>    20== K02320   1 D.melanogaster opsin <>[Cell40,851-858'85]
ME-------------------SFAVAAAQLGPHFAPLS-----------------NGSVV
-----------DKVTPDMAH------LISPYWN-----------QFPAMDPIWA------
------------------KILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINL
AISDFGIMITN-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDR
YQVIVKGMAG-RPMTIPLALGKM---------------------------YVPEGNLTSC
GIDYLE--RDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKA-----------
------------------------------------------------------------
------------------------------------------------------------
---MREQAKK----------MNVKSL----------------RS-SEDAEKSAEGKLAKV
ALVTITLWFMAWTPYLVINCMGLF-KF-E--GLTPLNTIWGACFAKSAACYNPIVYGISH
PKYRLALKEKCP----CCVFGKVDDGK-SS-DAQSQATASEA------------------
------------------------------------------------------------
---E--------------SK-A----------
>    21== K02315   1 D.melanogaster ninaE <>[Cell40,839-850'85]
ME-------------------SFAVAAAQLGPHFAPLS-----------------NGSVV
-----------DKVTPDMAH------LISPYWN-----------QFPAMDPIWA------
------------------KILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINL
AISDFGIMITN-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDR
YQVIVKGMAG-RPMTIPLALGKIAYIWFMSSIW-CLAPAFG-W-----SRYVPEGNLTSC
GIDYLE--RDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKA-----------
------------------------------------------------------------
------------------------------------------------------------
---MREQAKK----------MNVKSL----------------RS-SEDAEKSAEGKLAKV
ALVTITLWFMAWTPYLVINCMGLF-KF-E--GLTPLNTIWGACFAKSAACYNPIVYGISH
PKYRLALKEKCP----CCVFGKVDDGK-SS-DAQSQATASEA------------------
------------------------------------------------------------
---E--------------SK-A----------
>    22== X65877   1 Drosophila pseudoobscura Dpse\ninaE <>[Genetics132(1),193-204'
MD-------------------SFAAVATQLGPQFAAPS-----------------NGSVV
-----------DKVTPDMAH------LISPYWD-----------QFPAMDPIWA------
------------------KILTAYMIIIGMISWCGNGVVIYIFATTKSLRTPANLLVINL
AISDFGIMITN-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDR
YQVIVKGMAG-RPMTIPLALGKIAYIWFMSTIWCCLAPVFG-W-----SRYVPEGNLTSC
GIDYLE--RDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKA-----------
------------------------------------------------------------
------------------------------------------------------------
---MREQAKK----------MNVKSL----------------RS-SEDADKSAEGKLAKV
ALVTISLWFMAWTPYLVINCMGLF-KF-E--GLTPLNTIWGACFAKSAACYNPIVYGISH
PKYRLALKEKCP----CCVFGKVDDGK-SS-EAQSQATTSEA------------------
------------------------------------------------------------
---E--------------SK-A----------
>    23== M12896   1 D.melanogaster Rh2 <>[Cell44,705-710'86]
MERSH--------------LPETPFDLAHSGPRFQAQSSG---------------NGSVL
-----------DNVLPDMAH------LVNPYWS-----------RFAPMDPMMS------
------------------KILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLNL
AFSDFCMMASQ-SPVMIINFYY-ETWV--LGPLWCDIYAGCGSLFGCVSIWSMCMIAFDR
YNVIVKGING-TPMTIKTSIMKILFIWMMAVFW-TVMPLIG-W-----SAYVPEGNLTAC
SIDYMT--RMWNPRSYLITYSLFVYYTPLFLICYSYWFIIAAVAAHEKA-----------
------------------------------------------------------------
------------------------------------------------------------
---MREQAKK----------MNVKSL----------------RS-SEDCDKSAEGKLAKV
ALTTISLWFMAWTPYLVICYFGLF-KI-D--GLTPLTTIWGATFAKTSAVYNPIVYGISH
PKYRIVLKEKCP----MCVFGNTDEPKPDA-PASDTETTSEA------------------
------------------------------------------------------------
---D--------------SK-A----------
>    24== X65878   1 Drosophila pseudoobscura Dpse\Rh2 <>[Genetics132(1),193-204'92
MERSL--------------LPEPPLAMALLGPRFEAQTGG---------------NRSVL
-----------DNVLPDMAP------LVNPHWS-----------RFAPMDPTMS------
------------------KILGLFTLVILIISCCGNGVVVYIFGGTKSLRTPANLLVLNL
AFSDFCMMASQ-SPVMIINFYY-ETWV--LGPLWCDIYAACGSLFGCVSIWSMCMIAFDR
YNVIVKGING-TPMTIKTSIMKIAFIWMMAVFW-TIMPLIG-W-----SSYVPEGNLTAC
SIDYMT--RQWNPRSYLITYSLFVYYTPLFMICYSYWFIIATVAAHEKA-----------
------------------------------------------------------------
------------------------------------------------------------
---MRDQAKK----------MNVKSL----------------RS-SEDCDKSAENKLAKV
ALTTISLWFMAWTPYLIICYFGLF-KI-D--GLTPLTTIWGATFAKTSAVYNPIVYGISH
PNDRLVLKEKCP----MCVCGTTDEPKPDA-PPSDTETTSEA------------------
------------------------------------------------------------
---E--------------SK-D----------
>    25== U26026   1 Apis mellifera long-wavelength rhodopsin <>[]
MI-------------------------AVSGPSYEAFSYGGQA-----RF----NNQTVV
-----------DKVPPDMLH------LIDANWY-----------QYPPLNPMWH------
------------------GILGFVIGMLGFVSAMGNGMVVYIFLSTKSLRTPSNLFVINL
AISNFLMMFCM-SPPMVINCYY-ETWV--LGPLFCQIYAMLGSLFGCGSIWTMTMIAFDR
YNVIVKGLSG-KPLSINGALIRIIAIWLFSLGW-TIAPMFG-W-----NRYVPEGNMTAC
GTDYFN--RGLLSASYLVCYGIWVYFVPLFLIIYSYWFIIQAVAAHEKN-----------
------------------------------------------------------------
------------------------------------------------------------
---MREQAKK----------MNVASL----------------RS-SENQNTSAECKLAKV
ALMTISLWFMAWTPYLVINFSGIF-NL-V--KISPLFTIWGSLFAKANAVYNPIVYGISH
PKYRAALFAKFP----SLAC-AAEPSS-DA-VSTTSGTTTVT------------------
------------------------------------------------------------
---DNEK-----------SN-A----------
>    26== L03781   1 Limulus polyphemus opsin <>[PNAS90,6150-6154'93]
M---------------------------ANQLSYSSLGWPYQP------------NASVV
-----------DTMPKEMLY------MIHEHWY-----------AFPPMNPLWY------
------------------SILGVAMIILGIICVLGNGMVIYLMMTTKSLRTPTNLLVVNL
AFSDFCMMAFM-MPTMTSNCFA-ETWI--LGPFMCEVYGMAGSLFGCASIWSMVMITLDR
YNVIVRGMAA-APLTHKKATLLLLFVWIWSGGW-TILPFFG-W-----SRYVPEGNLTSC
TVDYLT--KDWSSASYVVIYGLAVYFLPLITMIYCYFFIVHAVAEHEKQ-----------
------------------------------------------------------------
------------------------------------------------------------
---LREQAKK----------MNVASL----------------RANADQQKQSAECRLAKV
AMMTVGLWFMAWTPYLIISWAGVF-SSGT--RLTPLATIWGSVFAKANSCYNPIVYGISH
PRYKAALYQRFP----SLACGSGESGS-DV-KSEASATTTME------------------
------------------------------------------------------------
---EKPK----------IPE-A----------
>    27== X07797   1 Octopus dofleini rhodopsin <>[FEBS232(1),69-72'88]
MVESTTL------------VNQT--------------------------WWY---NPTVD
---------------------------IHPHWA-----------KFDPIPDAVY------
------------------YSVGIFIGVVGIIGILGNGVVIYLFSKTKSLQTPANMFIINL
AMSDLSFSAINGFPLKTISAFM-KKWI--FGKVACQLYGLLGGIFGFMSINTMAMISIDR
YNVIGRPMAASKKMSHRRAFLMIIFVWMWSIVW-SVGPVFN-W-----GAYVPEGILTSC
SFDYLS--TDPSTRSFILCMYFCGFMLPIIIIAFCYFNIVMSVSNHEKE-----------
------------------------------------------------------------
------------------------------------------------------------
---MAAMAKR----------LNAKEL----------------R--KAQAGASAEMKLAKI
SMVIITQFMLSWSPYAIIALLAQF-GPAE--WVTPYAAELPVLFAKASAIHNPIVYSVSH
PKFREAIQTTFPWLLTCCQFDEKECED-AN-DAEEEVVASER--GGESRDAAQMKEMMAM
MQKMQAQQAAYQPPPPPQGY--PPQGYPPQGAYPPPQGYPPQGYPPQGYPPQGYPPQGAP
PQVEAPQGAPPQGVDNQAYQ-A----------
>    28== X70498   1 Todarodes pacificus rhodopsin <retina>[FEBS317(1-2),5-11'93]
MGRDLR-------------DNET--------------------------WWY---NPSIV
---------------------------VHPHWR-----------EFDQVPDAVY------
------------------YSLGIFIGICGIIGCGGNGIVIYLFTKTKSLQTPANMFIINL
AFSDFTFSLVNGFPLMTISCFL-KKWI--FGFAACKVYGFIGGIFGFMSIMTMAMISIDR
YNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLW-AIGPIFG-W-----GAYTLEGVLCNC
SFDYIS--RDSTTRSNILCMFILGFFGPILIIFFCYFNIVMSVSNHEKE-----------
------------------------------------------------------------
------------------------------------------------------------
---MAAMAKR----------LNAKEL----------------R--KAQAGANAEMRLAKI
SIVIVSQFLLSWSPYAVVALLAQF-GPLE--WVTPYAAQLPVMFAKASAIHNPMIYSVSH
PKFREAISQTFPWVLTCCQFDDKETED-DK-DAETEIPAGESSDAAPSADAAQMKEMMAM
MQKMQQQQAAY----PPQGYAPPPQGYPPQGY--PPQGYPPQGYPPQGYPP---PPQGAP
PQ-GAPPAAPPQGVDNQAYQ-A----------
>    29== L21195   1 human serotonin 5-HT7 receptor protein <placenta and fetal bra
MMDVNS-------------SGRPDLY----GHLRSFLLP--EVG----------RGLPDL
SPDGGADPVAGSWAPHLLS---EVTASPAPTWD------------APPDNASGC------
-------GEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSL
ALADLSVAVAV-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDR
YLGITRPLTYPVRQNGKCMAKMILSVWLLSASI-TLPPLFG-W-----AQNVNDDK--VC
LIS--------QDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKF--------
---------PGF---------------------------------PRVEPDSVI------
----------------ALNGIVK----------------------LQKEVEECAN-----
---LSRLLKH--------------------------------ER-KNISIFKREQKAATT
LGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFN
RDLRTTYRSLLQ--------CQYRNIN----RKLSAAGMHEA------------------
-LKLA-------------------------------------------------------
---ERPE------RPEFVLQNADYCRKKGHDS
>    30== L15228   1 rat 5HT-7 serotonin receptor <>[JBC268,18200-18204'93]
M-----------------------------------------------------------
--------------PHLLSGFLEVTASPAPTWD------------APPDNVSGC------
-------GEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLIVSL
ALADLSVAVAV-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDR
YLGITRPLTYPVRQNGKCMAKMILSVWLLSASI-TLPPLFG-W-----AQNVNDDK--VC
LIS--------QDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKF--------
---------PGF---------------------------------PRVQPESVI------
----------------SLNGVVK----------------------LQKEVEECAN-----
---LSRLLKH--------------------------------ER-KNISIFKREQKAATT
LGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFN
RDLRPTSRSLLQ--------CQYRNIN----RKLSAAGMHEA------------------
-LKLA-------------------------------------------------------
---ERPE------RSEFVLQNSDHCGKKGHDT
>    31=p A47425 serotonin receptor 5HT-7 - rat
M-----------------------------------------------------------
--------------PHLLSGFLEVTASPAPTWD------------APPDNVSGC------
-------GEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLIVSL
ALADLSVAVAV-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDR
YLGITRPLTYPVRQNGKCMAKMILSVWLLSASI-TLPPLFG-W-----AQNVNDDK--VC
LIS--------QDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKF--------
---------PGF---------------------------------PRVQPESVI------
----------------SLNGVVK----------------------LQKEVEECAN-----
---LSRLLKH--------------------------------ER-KNISIFKREQKAATT
LGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFN
RDLRTTYRSLLQ--------CQYRNIN----RKLSAAGMHEA------------------
-LKLA-------------------------------------------------------
---ERPE------RSEFVLQNSDHCGKKGHDT
>    32== M83181   1 human serotonin receptor <>[JBC267(11),7553-7562'92]
M-DVLS-------------PGQ--------GNNTTSPPAPFETG----------GNTTGI
-------------------------SDVTVSYQ---------------------------
------------------VITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSL
AVTDLMVSVLV-LPMAALYQVL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIALDR
YWAITDPIDYVNKRTPRRAAALISLTWLIGFLI-SIPPMLG-WRTP--EDRSDPD---AC
TIS--------KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRK-----------
----------------------------TVKKVEKTGADTRHGASPAPQPKKSVNGESGS
RNWRLGVESKAGGAL-CANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAP-
----ASFERK-----------NERNA----------------EA-KRKMALARERKTVKT
LGIIMGTFILCWLPFFIVALVLPF-CESSC-HMPTLLGAIINWLGYSNSLLNPVIYAYFN
KDFQNAFKKIIK--------CKFCR-----------------------------------
------------------------------------------------------------
-------------------------------Q
>    33=p A35181 serotonin receptor class 1A - rat
M-DVFS-------------FGQ--------GNNTTASQEPFGTG----------GNVTSI
-------------------------SDVTFSYQ---------------------------
------------------VITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSL
AVTDLMVSVLV-LPMAALYQVL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIALDR
YWAITDPIDYVNKRTPRRAAALISLTWLIGFLI-SIPPMLG-WRTP--EDRSDPD---AC
TIS--------KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRK-----------
----------------------------TVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGS
GDWRRCAENRAVGTP-CTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAP-
----ACLERK-----------NERNA----------------EA-KRKMALARERKTVKT
LGIIMGTFILCWLPFFIVALVLPF-CESSC-HMPALLGAIINWLGYSNSLLNPVIYAYFN
KDFQNAFKKIIK--------CKFCR-----------------------------------
------------------------------------------------------------
-------------------------------R
>    34== L06803   1 Lymnaea stagnalis serotonin receptor <>[PNAS90,11-15'93]
M-ANFT-------------FGDLALDVARMGGLASTPSGLRSTG----------LTTPGL
SPTG------------------LVTSDFNDSYGLTGQFINGSHSSRSRDNASAN-DTSAT
NMTDDRYWSLTVYSHEHLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLILSL
AVADLMVAVLV-MPLSVVSEIS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIAMDR
YWAVTS-IDYIRRRSARRILLMIMVVWIVALFI-SIPPLFG-WRDP--NN--DPDKTGTC
IIS--------QDKGYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRIRKDKFQMTKARLK
TEETTLVASPKTEYSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKK--------
--------NRAKKLPENANGVNSNSSSSERLKQIQIE-----------TAEAFANGCAEE
AS-IAMLERQ-CNNGKKISSNDTPYS----------------RT-REKLELKRERKAART
LAIITGAFLICWLPFFIIALIGPF-VDPE--GIPPFARSFVLWLGYFNSLLNPIIYTIFS
PEFRSAFQKILF--------GKYRRG----------------------------------
------------------------------------------------------------
------------------------------HR
>    35=p A47174 serotonin receptor, 5HTlym receptor - great pond snail
M-ANFT-------------FGDLALDVARMGGLASTPSGLRSTG----------LTTPGL
SPTG------------------LVTSDFNDSYGLTGQFINGSHSSRSRDNASAN-DTSAT
NMTDDRYWSLTVYSHEHLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLILSL
AVADLMVAVLV-MPLSVVSEIS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIAMDR
YWAVTS-IDYIRRRSARRILLMIMVVWIVALFI-SIPPLFG-WRDP--NN--DPDKTGTC
IIS--------QDKGYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRIRKDKFQMTKARLK
TEETTLVASPKTEYSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKK--------
--------NRAKKLPENANGVNSNSSSSERLKQIQIE-----------TAEAFANGCAEE
AS-IAMLERQ-CNNGKKISSNDTPYS----------------RT-REKLELKRERKAART
LAIITGAFLICWLPFFIIALIGPF-VDPE--GIPPFARSFVLWLGYFNSLLNPIIYTIFS
PEFRSAFQKILF--------GKYRRG----------------------------------
------------------------------------------------------------
------------------------------HR
>    36== X95604   1 Bombyx mori serotonin receptor <antennae>[InsectBiochem.Mol.Bi
M-EG-A-------------EGQEELD----WEALYLRLPLQNCS----------WNSTGW
EPNW------------------NVTVVPNTTWW----------------QASAPFDTPAA
LVRA--------------AAKAVVLGLLILATVVGNVFVIAAILLERHLRSAANNLILSL
AVADLLVACLV-MPLGAVYEVV-QRWT--LGPELCDMWTSGDVLCCTASILHLVAIALDR
YWAVTN-IDYIHASTAKRVGMMIACVWTVSFFV-CIAQLLG-WKDPDWNQRVSEDL--RC
VVS--------QDVGYQIFATASSFYVPVLIILILYWRIYQTARKRIRR-----------
----------------------------------RRGATARGGVGPPPVP----------
-----------------AGGALVAGGGSGGIAAAVVAVIGRP---LPTISETTTTGFTNV
SSNNTSPEKQSCANGLEA---DPPTTGYGAVAAAYYPSLVRRKP-KEAADSKRERKAAKT
LAIITGAFVACWLPFFVLAILVPT-CDCE---VSPVLTSLSLWLGYFNSTLNPVIYTVFS
PEFRHAFQRLLC--------GRRVRRR----R----------------------------
------------------------------------------------------------
-----------------------------APQ